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We are pleased to announce that dbAMP 3.0 was released in June 2024.

Here is a brief video introduction of dbAMP 3.0: [YouTube Link] or [Bilibili Link]

   (Search by Antimicrobial Peptides Name/Targets, e.g. Alpha-Defensin or reported activities against SARS-CoV)

dbAMP 3.0: updated resource of antimicrobial activity and structural annotation of peptides in the post-pandemic era

An integrated system for identifying Anti-Microbial Peptides (AMPs) with their functional types based on high-throughput transcriptome and proteome data. In recent years, the widespread use of antibiotics has inspired the rapid growth of antibiotic-resistant microorganisms that usually induce critical infection and pathogenesis. However, as the key components of innate immunity, human host defense antimicrobial peptides and proteins (AMPs) play a critical role in warding off invading microbial pathogens. Typical examples are Human γδ T cells produce antimicrobial peptide elafin (dbAMP_00487) which is the major antiviral protein in cervicovaginal lavage fluid. Human Lactoferricin derivatives (dbAMP_04016) shows an inhibitory effect on bacteria and melanoma cells.

35,518

Peptides

3,534

Organisms

30,000+

Structures

6,227

Target

5,200+

References
Major Improvements

Citing dbAMP:
Jhong, J.H., et al., dbAMP 2.0: updated resource for antimicrobial peptides with an enhanced scanning method for genomic and proteomic data. Nucleic Acids Res, 2021.

About Us

The database is developed by Dr.Lee's team. This is the home page of the database, please use the navigation bar in the top of page to browse the database. If you encounter any problems in using this database, you can consult the FAQs/help pages for help or feedback to us, we will help you solve as soon as possible.

PDB ID: 1Z6V Human Lactoferricin derivatives (dbAMP_04016). A human milk fraction was active against S. mutants, B. subtilis, P. aeruginosa, and E. coli (MIC 32 ug/ml). It also exhibits growth stimulating activity in 3T3 cell line (Mandal SM et al. 2014). It also has anticancer activity by targeting phophatidylserine (PS) Riedl S et al., 2014.
Amino acid color codes
Polar positive
Polar negative
Polar neutral
Nonpolar aliphatic
Nonpolar aromatic
Recent Update History
We are pleased to announce that dbAMP 3.0 was released in June 2024.

T.Y. LEE

At 20th June, 2024
We are updating dbAMP, and dbAMP 2025 is coming soon!

T.Y. LEE

At 15th May, 2024
The dbAMP 2.0 had been published.

T.Y. LEE

At 25th Dec, 2021
The updated dbAMP 2022 is coming soon.

T.Y. LEE

At 23th Jul, 2021
16,320 new entries with over 2,000 refreence sources have been added to dbAMP.

T.Y. LEE

At 20th May, 2021
105 new entries about stapled Anti-MRSA peptides have been added to dbAMP.

T.Y. LEE

At 20th Feb, 2021
-Database update!

T.Y. LEE

At 13th Feb, 2021
All published dbAMP Sequence/Annotation data has been open to download now!

T.Y. LEE

At 20th June, 2019
The Target Activity Alignment Info has been open.

T.Y. LEE

At 15th June, 2018
-Database update!

T.Y. LEE

At 25th August, 2017
The protein structure viwer has been open.

T.Y. LEE

At 21th April, 2017
-dbAMP V1.0 released! Comments and suggestions are welcome!

T.Y. LEE

At 25th November, 2016
We are responsible for maintaining the website daily and updating the database regularly.

T.Y. LEE

At 25th November, 2016

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