ABCC9_HUMAN - dbPTM
ABCC9_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABCC9_HUMAN
UniProt AC O60706
Protein Name ATP-binding cassette sub-family C member 9
Gene Name ABCC9
Organism Homo sapiens (Human).
Sequence Length 1549
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation..
Protein Sequence MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
9N-linked_GlycosylationSLSFCGNNISSYNIN
CCCCCCCCCCCCCCC
22.32UniProtKB CARBOHYD
163PhosphorylationCQSGLDISNLRFCIT
HCCCCCCCCCCHHHH
29.4924719451
170PhosphorylationSNLRFCITGMMVILN
CCCCHHHHHHHHHHH
21.8724719451
193PhosphorylationNVIRVRRYVFFMNPQ
CEEEEEEEEEECCCC
7.3430576142
227PhosphorylationVNLLSKATYWWMNTL
HHHHHHHHHHHHHHH
24.3429759185
228PhosphorylationNLLSKATYWWMNTLI
HHHHHHHHHHHHHHH
11.2629759185
233PhosphorylationATYWWMNTLIISAHK
HHHHHHHHHHHHCCC
11.8329759185
237PhosphorylationWMNTLIISAHKKPID
HHHHHHHHCCCCCCC
19.8246156805
282PhosphorylationVADHPNRTPSIWLAM
HCCCCCCCHHHHHHH
28.2029759185
284PhosphorylationDHPNRTPSIWLAMYR
CCCCCCHHHHHHHHH
26.2829759185
326N-linked_GlycosylationSGIVQRVNETQNGTN
HHHHHHHHHCCCCCC
49.11UniProtKB CARBOHYD
330N-linked_GlycosylationQRVNETQNGTNNTTG
HHHHHCCCCCCCCCC
67.68UniProtKB CARBOHYD
333N-linked_GlycosylationNETQNGTNNTTGISE
HHCCCCCCCCCCCCC
45.29UniProtKB CARBOHYD
334N-linked_GlycosylationETQNGTNNTTGISET
HCCCCCCCCCCCCCC
38.56UniProtKB CARBOHYD
527PhosphorylationETRMKELSSLKTFAL
HHHHHHHHHHHHHHH
34.4124719451
590PhosphorylationTPLFLLSTVVRFAVK
HHHHHHHHHHHHHHH
24.0024719451
621PhosphorylationIGDDSWRTGESSLPF
CCCCCCCCCCCCCCH
38.7626437602
630PhosphorylationESSLPFESCKKHTGV
CCCCCHHHHCCCCCC
31.4526437602
650PhosphorylationNRKQPGRYHLDSYEQ
CCCCCCCCCCCCHHH
16.7926437602
658PhosphorylationHLDSYEQSTRRLRPA
CCCCHHHCCCCCCCC
16.3726437602
771PhosphorylationATVEENITFGSPFNK
EEEECCCCCCCCCCH
33.2646156817
936PhosphorylationQTTLERKTLRRAMYS
HHHHHHHHHHHHHHC
31.5522210691
969PhosphorylationDEDDNMSTVMRLRTK
CCCCCHHHHHHHHCC
13.9325554490
985PhosphorylationPWKTCWRYLTSGGFF
CHHHHHHHHHHHHHH
6.9922210691
987PhosphorylationKTCWRYLTSGGFFLL
HHHHHHHHHHHHHHH
19.1822210691
1000PhosphorylationLLILMIFSKLLKHSV
HHHHHHHHHHHCCCH
16.0924719451
1321PhosphorylationIHDLCVRYENNLKPV
EHHHHHHCCCCCHHH
11.5669212609
1350PhosphorylationGICGRTGSGKSSLSL
EEECCCCCCHHHHHH
42.299873691
1378PhosphorylationVIDGIDISKLPLHTL
EEECEEHHHCCHHHH
25.139873703
1387PhosphorylationLPLHTLRSRLSIILQ
CCHHHHHHHHHHHHC
40.4624905233
1390PhosphorylationHTLRSRLSIILQDPI
HHHHHHHHHHHCCCE
13.3824905233
1414PhosphorylationLDPECKCTDDRLWEA
CCCCCCCCCHHHHHH
26.8246156811
1499PhosphorylationMTAFADRTVVTIAHR
HHHHCCCEEHHHHHH
21.6327251275
1499 (in isoform 2)Phosphorylation-21.6327251275
1502 (in isoform 2)Phosphorylation-14.2227251275
1509 (in isoform 2)Phosphorylation-21.0527251275
1512PhosphorylationHRVSSIMDAGLVLVF
HHHHHHCCCCEEEEE
35.5027251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABCC9_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABCC9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABCC9_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ABCC9_HUMAN !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABCC9_HUMAN

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Related Literatures of Post-Translational Modification

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