UniProt ID | ABCC9_HUMAN | |
---|---|---|
UniProt AC | O60706 | |
Protein Name | ATP-binding cassette sub-family C member 9 | |
Gene Name | ABCC9 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 1549 | |
Subcellular Localization |
Membrane Multi-pass membrane protein . | |
Protein Description | Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.. | |
Protein Sequence | MSLSFCGNNISSYNINDGVLQNSCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLRFCITGMMVILNGLLMAVEINVIRVRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLVMTNK | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
9 | N-linked_Glycosylation | SLSFCGNNISSYNIN CCCCCCCCCCCCCCC | 22.32 | UniProtKB CARBOHYD | |
163 | Phosphorylation | CQSGLDISNLRFCIT HCCCCCCCCCCHHHH | 29.49 | 24719451 | |
170 | Phosphorylation | SNLRFCITGMMVILN CCCCHHHHHHHHHHH | 21.87 | 24719451 | |
193 | Phosphorylation | NVIRVRRYVFFMNPQ CEEEEEEEEEECCCC | 7.34 | 30576142 | |
227 | Phosphorylation | VNLLSKATYWWMNTL HHHHHHHHHHHHHHH | 24.34 | 29759185 | |
228 | Phosphorylation | NLLSKATYWWMNTLI HHHHHHHHHHHHHHH | 11.26 | 29759185 | |
233 | Phosphorylation | ATYWWMNTLIISAHK HHHHHHHHHHHHCCC | 11.83 | 29759185 | |
237 | Phosphorylation | WMNTLIISAHKKPID HHHHHHHHCCCCCCC | 19.82 | 46156805 | |
282 | Phosphorylation | VADHPNRTPSIWLAM HCCCCCCCHHHHHHH | 28.20 | 29759185 | |
284 | Phosphorylation | DHPNRTPSIWLAMYR CCCCCCHHHHHHHHH | 26.28 | 29759185 | |
326 | N-linked_Glycosylation | SGIVQRVNETQNGTN HHHHHHHHHCCCCCC | 49.11 | UniProtKB CARBOHYD | |
330 | N-linked_Glycosylation | QRVNETQNGTNNTTG HHHHHCCCCCCCCCC | 67.68 | UniProtKB CARBOHYD | |
333 | N-linked_Glycosylation | NETQNGTNNTTGISE HHCCCCCCCCCCCCC | 45.29 | UniProtKB CARBOHYD | |
334 | N-linked_Glycosylation | ETQNGTNNTTGISET HCCCCCCCCCCCCCC | 38.56 | UniProtKB CARBOHYD | |
527 | Phosphorylation | ETRMKELSSLKTFAL HHHHHHHHHHHHHHH | 34.41 | 24719451 | |
590 | Phosphorylation | TPLFLLSTVVRFAVK HHHHHHHHHHHHHHH | 24.00 | 24719451 | |
621 | Phosphorylation | IGDDSWRTGESSLPF CCCCCCCCCCCCCCH | 38.76 | 26437602 | |
630 | Phosphorylation | ESSLPFESCKKHTGV CCCCCHHHHCCCCCC | 31.45 | 26437602 | |
650 | Phosphorylation | NRKQPGRYHLDSYEQ CCCCCCCCCCCCHHH | 16.79 | 26437602 | |
658 | Phosphorylation | HLDSYEQSTRRLRPA CCCCHHHCCCCCCCC | 16.37 | 26437602 | |
771 | Phosphorylation | ATVEENITFGSPFNK EEEECCCCCCCCCCH | 33.26 | 46156817 | |
936 | Phosphorylation | QTTLERKTLRRAMYS HHHHHHHHHHHHHHC | 31.55 | 22210691 | |
969 | Phosphorylation | DEDDNMSTVMRLRTK CCCCCHHHHHHHHCC | 13.93 | 25554490 | |
985 | Phosphorylation | PWKTCWRYLTSGGFF CHHHHHHHHHHHHHH | 6.99 | 22210691 | |
987 | Phosphorylation | KTCWRYLTSGGFFLL HHHHHHHHHHHHHHH | 19.18 | 22210691 | |
1000 | Phosphorylation | LLILMIFSKLLKHSV HHHHHHHHHHHCCCH | 16.09 | 24719451 | |
1321 | Phosphorylation | IHDLCVRYENNLKPV EHHHHHHCCCCCHHH | 11.56 | 69212609 | |
1350 | Phosphorylation | GICGRTGSGKSSLSL EEECCCCCCHHHHHH | 42.29 | 9873691 | |
1378 | Phosphorylation | VIDGIDISKLPLHTL EEECEEHHHCCHHHH | 25.13 | 9873703 | |
1387 | Phosphorylation | LPLHTLRSRLSIILQ CCHHHHHHHHHHHHC | 40.46 | 24905233 | |
1390 | Phosphorylation | HTLRSRLSIILQDPI HHHHHHHHHHHCCCE | 13.38 | 24905233 | |
1414 | Phosphorylation | LDPECKCTDDRLWEA CCCCCCCCCHHHHHH | 26.82 | 46156811 | |
1499 | Phosphorylation | MTAFADRTVVTIAHR HHHHCCCEEHHHHHH | 21.63 | 27251275 | |
1499 (in isoform 2) | Phosphorylation | - | 21.63 | 27251275 | |
1502 (in isoform 2) | Phosphorylation | - | 14.22 | 27251275 | |
1509 (in isoform 2) | Phosphorylation | - | 21.05 | 27251275 | |
1512 | Phosphorylation | HRVSSIMDAGLVLVF HHHHHHCCCCEEEEE | 35.50 | 27251275 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ABCC9_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ABCC9_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ABCC9_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of ABCC9_HUMAN !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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