Welcome to CircNet 2.0

——an updated database for exploring circular RNA regulatory networks in cancers

Circular RNAs (circRNAs) are a type of single-stranded RNAs that can form a covalently closed continuous loop acting as a microRNA (miRNA) sponge, interacts with RNA-binding proteins, or encoding proteins. CircRNA plays an important role in the fields of cancer diagnosis and drug development as growing evidence suggest circRNAs have a close relationship to clinical and pathological cancer features. Therefore, circRNA proves to have high potential in becoming novel carcinoma biomarkers. Due to the regulatory role of circRNAs in eukaryotic cells, we proposed the first circRNA database, CircNet, dedicated to providing tissue-specific circRNA expression profiles and circRNA-miRNA-gene regulatory network . Since the publication of CircNet in January 2016, the database has accumulated 200+ research works that have referred to CircNet annotations, mostly emphasizing on exploring regulatory network of circRNAs in a wide array of cancers.

The number of circRNA in TOP 15 cancers
Major Improvements
MiOncoCirc CircAtlas 2.0 CircNet 1.0 CircNet 2.0
Publication Cell(2019) Genome Biol.(2020) NAR Database Issue(2016) Submitted
Last Update 2018 2019 2015 2021
Support species

Homo sapiens

6 species Homo sapiens

Homo sapiens

Number of cancer types 19 0 0 37
Number of samples 2000+ cancer samples 1070 samples 464 samples 2,732 cancer samples
Data sources GEO SRA
Circular RNA detection methods CIRCexplorer
Memczak's algorism CIRI2/CIRI-full
CircRNA-miRNA interaction no yes yes yes
miRNA-gene interaction no no yes yes
circRNA expression yes yes yes yes
microRNA expression no no no yes
Other characteristics - Conserved score,
circRNA-miRNA network,
circRNA annotation
Expression profiles of circRNA isoforms CircRNA annotation,
circRNA-miRNA-Gene network,
GO analysis,
KEGG analysis,
Disease enrichment analysis
Research Works referred to CircNet
  • Kulcheski F R, Christoff A P, Margis R. Circular RNAs are miRNA sponges and can be used as a new class of biomarker[J]. Journal of biotechnology, 2016, 238: 42-51.
  • Zeng K, Chen X, Xu M U, et al. CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7[J]. Cell death & disease, 2018, 9(4): 1-15.
  • Shan K, Liu C, Liu B H, et al. Circular noncoding RNA HIPK3 mediates retinal vascular dysfunction in diabetes mellitus[J]. Circulation, 2017, 136(17): 1629-1642.
  • Panda AC. Circular RNAs Act as miRNA Sponges. Adv Exp Med Biol. 2018; 1087:67-79.
  • Zhang Z, Yang T, Xiao J. Circular RNAs: Promising Biomarkers for Human Diseases. EBioMedicine. 2018 Aug;34:267-274.
  • ......
  • External Links
    About Us

    The database is developed by Dr.Lee's team. This is the home page of the database, please use the navigation bar in the top of page to search or browse the database. If you encounter any problems in using this database, you can consult the contact page for help, we will help you solve as soon as possible.