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miRTarBase - #MIRT672290 -
pre-miRNA Information
pre-miRNA hsa-mir-122   
Genomic Coordinates chr18: 58451074 - 58451158
Synonyms MIR122A, MIRN122, MIRN122A, hsa-mir-122, miRNA122, miRNA122A, MIR122
Description Homo sapiens miR-122 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-122-5p
Sequence 15| UGGAGUGUGACAAUGGUGUUUG |36
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 18 + 58451091 29233923 MiREDiBase
C-to-U 11 18 + 58451098 28550310 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1258166649 1 dbSNP
rs1426570658 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles

Circulating MicroRNA Expression Profiling
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol GP2   
Synonyms ZAP75
Description glycoprotein 2
Transcript NM_001007240   
Other Transcripts NM_001007241 , NM_001007242 , NM_001502   
Expression
Putative miRNA Targets on GP2
3'UTR of GP2
(miRNA target sites are highlighted)		 
>GP2|NM_001007240|3'UTR
   1 GAGCTCCGCTGAGCATCTGGCCTTGAAGTTTGTGTTCTTCCCTCTGGCAATGGCTCCCTTCAGCACTTCTGCTTTCCACT
  81 CCAATTCACACAGGCTTGGTATTAACAGAATCAAGGCCAGGCTAGGTTAGGAAAAGGGAAGAGCTTTCACCTTCTTTAAA
 161 ACTCTCGGCTGGGCGCAGTGGCTCATGCCTGTAATCCCAGCATTTTGGGAGGCTGAGGCAGGTGGATCACCTGAGGTCAG
 241 CAGTTCAAAATCAGCCTGGCCAAAATGCTGAAACTCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGCAGG
 321 CGCCTGTAATCCCAGCTACTCGGGAGGCCAAGGCAGGAGAATTGCTCGAACTCAGGGGGTGGAGGTTGCAGTGAGTTGAG
 401 ATTGTGCCATTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTCTCAGGAAAAAAAAAAAAAAAAAAGAAAAGCAACA
 481 TAGTGGGGTTTCTGTCAATCTGTCCTCGGCTGCCCTTCTCATTTGTTGATGGGACCTTGAAAGCAAGCTTGCTAGGTGCC
 561 CTCTGTGGCTCCAGCCTTTACCGGAAGTGTGGTGCATGTTTTTAACTTCAGGGAAGCGGTATCCTGTCACTGGGGTATGG
 641 GATGAGCATGGAGAAGAGGCACCAGCCACGATTCCTTCCTAAGCATCTCCTGTTCTGACTGCTCATGAATTGAAGAAACT
 721 GACCCTTGTGTTCACTCTGCTTCCTCTGATTGTTTCTATCATGGTTTCCAAAAATTGCCATGGGAACATGTCAAAGGGCC
 801 ACTTTTGGAGACTCTGCTCCAGGAAGAACTAGTCCCCATAGCTCCCCTATCCCCCACCATACCACAGACATGCTGTGACT
 881 TAGAGAACTACACAAACATCCTTGGGACCTAGATGCTGGAGGAATGACTTAATTTGATGCAGAAACTCCATCACCCAAGG
 961 GAGTACCTCTCACTGTAAACAGTGCTGTGCTTGCTCTGAAGGATTAAGCAAGAAGTCCCAACAGAAGCAATGCACCAGTC
1041 CTGCTATGGGAATGAAACTGCAAAGCCTAGGAGATGGGTGAAGTCCCTTTCTGGAGACCTTTAATGAGTACTTCAAAGCA
1121 CCCGACACAGATGCAGCAAATAGGGCATCACACATACACAGGCATTAATACTCACGGGCATATAGATGCTGACATGTGTA
1201 CACTGACTTACGCCCTTCCCACAGCTACAGATAAGGCCTCGCAAAGTTGGCCTCAGAGACACATCAGGAACCAAGGTGGA
1281 CCAGCAGGTGCCGAGCCTGTGTATCTGCTTGGAGGAGACGTTCCAATGTGCTGCCTTGTTCAGAGATGGTGTAGTTGCAA
1361 GAAACAGAAACCCACCACAATTTCTCAGGCAAAAAGGGAGTTAATTATAAGGACATAAGAGCACAAAGTTCCAGTGCAAG
1441 AGATACATCCAGGCTGCACAAGCTCCGGGAGTGGGGCCTGGCAAGCCAAAAGAAACCAAAGTTTGTCTTGCCTTCTGTTC
1521 CTCTTTCTGAAGCCACATAGCCTTTTATGACTGTGTATTTTTGCATCGCTTTTGTTTTCTTTTTATGTCTCTGAAGCCAG
1601 CTTTTCCTGTTCACTCATCCCTTGATTAAATATGGACATTCTAGCTTCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions (Predicted by miRanda)
IDDuplex structurePositionScoreMFE
1 
miRNA  3' guuUGUGGUAACAGUGUGAGGu 5'
             :::|||||   :|||||| 
Target 5' attGTGCCATT---GCACTCCa 3'
 		401 - 419 140.00 -17.50
2 
miRNA  3' guUUGUGGUAAC--AGUGUGAGGu 5'
            |:|||:  ||  |: |||||| 
Target 5' tcAGCACTTCTGCTTTCCACTCCa 3'
 		60 - 83 130.00 -16.70
3 
miRNA  3' guUUG--UGGUAACA-GUGUGAGGu 5'
            |||  ||| |||| : |||||: 
Target 5' gaAACTGACCCTTGTGTTCACTCTg 3'
 		715 - 739 122.00 -12.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31509801 6 COSMIC
COSN26442068 8 COSMIC
COSN30192443 22 COSMIC
COSN19690845 24 COSMIC
COSN30176414 25 COSMIC
COSN30475072 40 COSMIC
COSN30452734 41 COSMIC
COSN30516030 42 COSMIC
COSN30480408 56 COSMIC
COSN30132935 93 COSMIC
COSN31536369 101 COSMIC
COSN31497948 119 COSMIC
COSN31557995 174 COSMIC
COSN28833290 238 COSMIC
COSN20093091 470 COSMIC
COSN14987529 610 COSMIC
COSN17243460 616 COSMIC
COSN21241240 726 COSMIC
COSN5405284 820 COSMIC
COSN6081339 834 COSMIC
COSN25678038 996 COSMIC
COSN20152256 1211 COSMIC
COSN19536824 1240 COSMIC
COSN7300656 1381 COSMIC
COSN25576152 1414 COSMIC
rs12444232 1078 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs746606123 2 dbSNP
rs779722850 3 dbSNP
rs575694369 4 dbSNP
rs746403673 5 dbSNP
rs779528205 7 dbSNP
rs373559957 8 dbSNP
rs1288623941 13 dbSNP
rs1429325950 15 dbSNP
rs1235350941 16 dbSNP
rs1486669925 19 dbSNP
rs754152225 22 dbSNP
rs778136339 24 dbSNP
rs1469298158 27 dbSNP
rs756308591 34 dbSNP
rs923628535 37 dbSNP
rs981874260 39 dbSNP
rs752870863 40 dbSNP
rs1429310263 41 dbSNP
rs753873896 42 dbSNP
rs767616963 44 dbSNP
rs1190854081 45 dbSNP
rs1185707302 47 dbSNP
rs1449322980 49 dbSNP
rs1167280631 53 dbSNP
rs1427937657 56 dbSNP
rs1338035701 57 dbSNP
rs111297739 61 dbSNP
rs1437581820 62 dbSNP
rs1320937924 66 dbSNP
rs1364203905 67 dbSNP
rs1225972298 79 dbSNP
rs1276537940 84 dbSNP
rs1345679646 91 dbSNP
rs1218105916 94 dbSNP
rs917382594 98 dbSNP
rs1208971444 100 dbSNP
rs11642182 106 dbSNP
rs568081722 117 dbSNP
rs11647569 120 dbSNP
rs1248934976 123 dbSNP
rs773059887 124 dbSNP
rs1478673243 126 dbSNP
rs951234888 141 dbSNP
rs530961892 166 dbSNP
rs1458960489 167 dbSNP
rs1160159826 168 dbSNP
rs1388263925 171 dbSNP
rs995075238 172 dbSNP
rs993548813 174 dbSNP
rs138616491 175 dbSNP
rs1453919592 179 dbSNP
rs565182731 209 dbSNP
rs1156884639 214 dbSNP
rs1015373346 217 dbSNP
rs11553580 220 dbSNP
rs1418263789 222 dbSNP
rs1269285162 242 dbSNP
rs1201324374 246 dbSNP
rs1326690198 248 dbSNP
rs1203734827 260 dbSNP
rs1292500091 261 dbSNP
rs1452657695 268 dbSNP
rs11861170 277 dbSNP
rs890543969 278 dbSNP
rs1473609241 280 dbSNP
rs576966754 283 dbSNP
rs1205790521 286 dbSNP
rs1411477820 290 dbSNP
rs1028796737 292 dbSNP
rs1455861689 293 dbSNP
rs996430231 294 dbSNP
rs893666368 313 dbSNP
rs1053688513 314 dbSNP
rs935267476 317 dbSNP
rs902176048 321 dbSNP
rs1046487846 322 dbSNP
rs1321494158 324 dbSNP
rs775825401 339 dbSNP
rs770204368 341 dbSNP
rs1285509902 342 dbSNP
rs1403501691 345 dbSNP
rs1348190868 355 dbSNP
rs949133453 357 dbSNP
rs914081274 367 dbSNP
rs746355365 368 dbSNP
rs1357475804 372 dbSNP
rs189310662 374 dbSNP
rs568863711 376 dbSNP
rs115321800 379 dbSNP
rs12596974 385 dbSNP
rs969317174 387 dbSNP
rs962309277 391 dbSNP
rs1369329746 401 dbSNP
rs561693248 405 dbSNP
rs1429924229 406 dbSNP
rs1011482410 414 dbSNP
rs1472341276 419 dbSNP
rs1178308305 421 dbSNP
rs1161287362 424 dbSNP
rs917801380 427 dbSNP
rs1306834218 435 dbSNP
rs1368173450 439 dbSNP
rs1240216223 450 dbSNP
rs1397362307 450 dbSNP
rs1381973004 451 dbSNP
rs1339544619 452 dbSNP
rs1428823992 452 dbSNP
rs1194233482 460 dbSNP
rs1244485944 464 dbSNP
rs992047992 465 dbSNP
rs1229792741 466 dbSNP
rs1448982999 466 dbSNP
rs1202289237 467 dbSNP
rs1479685758 467 dbSNP
rs1257117542 468 dbSNP
rs10653884 470 dbSNP
rs1181459398 470 dbSNP
rs1300272247 470 dbSNP
rs1371310694 470 dbSNP
rs1391786669 470 dbSNP
rs1442115999 470 dbSNP
rs1449958299 470 dbSNP
rs1467131720 470 dbSNP
rs55892430 470 dbSNP
rs879063975 470 dbSNP
rs951183077 470 dbSNP
rs987890676 474 dbSNP
rs1259691671 475 dbSNP
rs1306336026 475 dbSNP
rs954792722 477 dbSNP
rs1235496131 479 dbSNP
rs1031325889 484 dbSNP
rs1256675103 485 dbSNP
rs1029473712 486 dbSNP
rs996289688 489 dbSNP
rs893635036 493 dbSNP
rs963828756 496 dbSNP
rs1222061159 500 dbSNP
rs1032214359 501 dbSNP
rs540217898 507 dbSNP
rs902437154 508 dbSNP
rs143450461 510 dbSNP
rs949093454 517 dbSNP
rs564366463 524 dbSNP
rs372375648 529 dbSNP
rs1467860204 531 dbSNP
rs1051983231 532 dbSNP
rs778827812 535 dbSNP
rs1327836471 537 dbSNP
rs1388974133 540 dbSNP
rs1292749069 551 dbSNP
rs1436272118 556 dbSNP
rs754859938 560 dbSNP
rs545679971 561 dbSNP
rs1360419333 563 dbSNP
rs997771798 568 dbSNP
rs1433793872 571 dbSNP
rs1406729526 580 dbSNP
rs894836133 582 dbSNP
rs1221809844 583 dbSNP
rs1270252283 585 dbSNP
rs1330151283 586 dbSNP
rs753717703 588 dbSNP
rs1052640038 594 dbSNP
rs936394143 600 dbSNP
rs575354538 617 dbSNP
rs925050428 618 dbSNP
rs557188215 621 dbSNP
rs1168317629 626 dbSNP
rs1476473549 634 dbSNP
rs1044841878 637 dbSNP
rs1412235843 638 dbSNP
rs1456389534 640 dbSNP
rs1158747634 646 dbSNP
rs1192541005 651 dbSNP
rs542283815 659 dbSNP
rs1002569597 661 dbSNP
rs917596116 664 dbSNP
rs1365548091 669 dbSNP
rs1403172629 676 dbSNP
rs574572926 683 dbSNP
rs1351272363 692 dbSNP
rs1461281287 698 dbSNP
rs920760659 704 dbSNP
rs973544465 708 dbSNP
rs369968164 710 dbSNP
rs951337586 729 dbSNP
rs918410748 732 dbSNP
rs973905845 746 dbSNP
rs908138257 750 dbSNP
rs963476218 751 dbSNP
rs987763262 752 dbSNP
rs1016737578 753 dbSNP
rs1251911730 754 dbSNP
rs1472035870 759 dbSNP
rs534691325 775 dbSNP
rs953463495 777 dbSNP
rs1425888383 784 dbSNP
rs954859646 786 dbSNP
rs1365445844 792 dbSNP
rs1029027272 802 dbSNP
rs1030377119 810 dbSNP
rs112444798 819 dbSNP
rs559159095 826 dbSNP
rs1309892557 827 dbSNP
rs892753647 829 dbSNP
rs1249328598 838 dbSNP
rs1441630867 839 dbSNP
rs1296637154 842 dbSNP
rs958109873 843 dbSNP
rs537258304 846 dbSNP
rs999375501 849 dbSNP
rs1357106822 857 dbSNP
rs559872710 862 dbSNP
rs1339805791 863 dbSNP
rs1329225197 869 dbSNP
rs1482428211 891 dbSNP
rs138011260 901 dbSNP
rs1013534632 904 dbSNP
rs1427312065 905 dbSNP
rs896136207 916 dbSNP
rs1182740961 926 dbSNP
rs1385042181 927 dbSNP
rs1056090469 933 dbSNP
rs929880874 934 dbSNP
rs1168239180 936 dbSNP
rs1409448583 939 dbSNP
rs1168497588 940 dbSNP
rs540199695 941 dbSNP
rs767119380 943 dbSNP
rs918526972 954 dbSNP
rs1054759782 972 dbSNP
rs941158081 975 dbSNP
rs911060386 977 dbSNP
rs548470755 992 dbSNP
rs1181857991 1000 dbSNP
rs986619175 1003 dbSNP
rs529031268 1006 dbSNP
rs1280137665 1017 dbSNP
rs953523411 1017 dbSNP
rs1209018707 1018 dbSNP
rs1190980524 1022 dbSNP
rs1240944129 1022 dbSNP
rs568151872 1022 dbSNP
rs898258845 1024 dbSNP
rs1030326150 1027 dbSNP
rs976106595 1041 dbSNP
rs1037811391 1046 dbSNP
rs1427390284 1057 dbSNP
rs940843334 1059 dbSNP
rs1031231549 1061 dbSNP
rs12444232 1078 dbSNP
rs1458609010 1083 dbSNP
rs903978374 1085 dbSNP
rs1325720959 1087 dbSNP
rs1428595478 1088 dbSNP
rs1023842980 1097 dbSNP
rs1367671788 1099 dbSNP
rs867361737 1108 dbSNP
rs1052438356 1120 dbSNP
rs10852240 1122 dbSNP
rs1243150233 1123 dbSNP
rs544327401 1124 dbSNP
rs1285399236 1130 dbSNP
rs11864405 1131 dbSNP
rs1249015814 1132 dbSNP
rs1478377854 1136 dbSNP
rs1198869020 1138 dbSNP
rs1427441957 1140 dbSNP
rs184978734 1150 dbSNP
rs1473700082 1157 dbSNP
rs374812278 1168 dbSNP
rs1384005810 1169 dbSNP
rs116859174 1175 dbSNP
rs978197328 1176 dbSNP
rs966933824 1183 dbSNP
rs1350467715 1185 dbSNP
rs941327112 1196 dbSNP
rs1024844206 1202 dbSNP
rs1013918964 1203 dbSNP
rs959321763 1211 dbSNP
rs538534354 1212 dbSNP
rs1350381557 1218 dbSNP
rs932042361 1225 dbSNP
rs563528576 1232 dbSNP
rs372162086 1233 dbSNP
rs12922283 1237 dbSNP
rs1266907379 1240 dbSNP
rs777712024 1241 dbSNP
rs1003999119 1242 dbSNP
rs923939062 1243 dbSNP
rs1409318165 1244 dbSNP
rs1160855123 1246 dbSNP
rs1414365277 1248 dbSNP
rs980088707 1262 dbSNP
rs1300700377 1264 dbSNP
rs1469076159 1265 dbSNP
rs772241127 1268 dbSNP
rs574635715 1271 dbSNP
rs886602175 1276 dbSNP
rs1237312966 1291 dbSNP
rs192045099 1293 dbSNP
rs1049732283 1297 dbSNP
rs1245922653 1305 dbSNP
rs748285606 1319 dbSNP
rs541030350 1320 dbSNP
rs1196527150 1323 dbSNP
rs1250068276 1324 dbSNP
rs1039031820 1327 dbSNP
rs1189282281 1328 dbSNP
rs929541997 1334 dbSNP
rs80260134 1341 dbSNP
rs1161571226 1346 dbSNP
rs993881042 1347 dbSNP
rs925304480 1358 dbSNP
rs1429818284 1360 dbSNP
rs1166866836 1363 dbSNP
rs1393794704 1364 dbSNP
rs978165897 1365 dbSNP
rs1336508362 1376 dbSNP
rs1383965813 1378 dbSNP
rs966859383 1379 dbSNP
rs1348494010 1381 dbSNP
rs896824379 1384 dbSNP
rs1313553368 1392 dbSNP
rs1345011671 1394 dbSNP
rs1228172097 1398 dbSNP
rs1250837123 1401 dbSNP
rs1337651558 1404 dbSNP
rs1287413573 1405 dbSNP
rs559003722 1407 dbSNP
rs116595845 1409 dbSNP
rs992013808 1414 dbSNP
rs1249797866 1415 dbSNP
rs1301570646 1418 dbSNP
rs1005870081 1421 dbSNP
rs959523342 1422 dbSNP
rs386789648 1423 dbSNP
rs576645463 1424 dbSNP
rs1399400353 1463 dbSNP
rs1033538796 1466 dbSNP
rs1177580293 1467 dbSNP
rs1469600669 1473 dbSNP
rs1160581814 1481 dbSNP
rs146386325 1481 dbSNP
rs367855523 1481 dbSNP
rs919538194 1482 dbSNP
rs922439731 1484 dbSNP
rs1189145093 1485 dbSNP
rs1487965573 1488 dbSNP
rs1040440204 1500 dbSNP
rs78425396 1501 dbSNP
rs1463443798 1503 dbSNP
rs1263985002 1507 dbSNP
rs1267501162 1509 dbSNP
rs1323163347 1511 dbSNP
rs536835232 1514 dbSNP
rs1204027451 1516 dbSNP
rs1015251444 1528 dbSNP
rs1325484121 1533 dbSNP
rs923929249 1537 dbSNP
rs1218828613 1540 dbSNP
rs558285213 1542 dbSNP
rs1004328266 1543 dbSNP
rs1434396511 1547 dbSNP
rs868559500 1549 dbSNP
rs1428094757 1550 dbSNP
rs189903712 1551 dbSNP
rs916814071 1552 dbSNP
rs4780282 1559 dbSNP
rs1288764339 1562 dbSNP
rs997711224 1564 dbSNP
rs900697409 1567 dbSNP
rs570397540 1568 dbSNP
rs1284012522 1579 dbSNP
rs545261275 1585 dbSNP
rs993871150 1595 dbSNP
rs1290501234 1601 dbSNP
rs1039293109 1602 dbSNP
rs1338002495 1610 dbSNP
rs1317262261 1614 dbSNP
rs936942810 1622 dbSNP
rs1238154110 1624 dbSNP
rs551868554 1630 dbSNP
rs1404301151 1631 dbSNP
rs1175834411 1641 dbSNP
rs1042395062 1647 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084041. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep1 HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
IDDuplex structurePosition
1 
miRNA  3' guuUGUGGUAACAGUGUGAGGu 5'
             :::|||||   :|||||| 
Target 5' auuGUGCCAUU---GCACUCCa 3'
 		6 - 24
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760631. RNA binding protein: AGO2. Condition:AGO-CLIP-22RV1_B ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM1084041
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep1
Location of target site ENST00000302555.5 | 3UTR | AGGUUGCAGUGAGUUGAGAUUGUGCCAUUGCACUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000302555.5 | 3UTR | UUGAGAUUGUGCCAUUGCACUCCAGCCUGGGCAACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer 0.47 3.3e-3 0.273 6.5e-2 32 Click to see details
GSE42095 Differentiated embryonic stem cells -0.492 8.5e-3 -0.103 3.2e-1 23 Click to see details
GSE17306 Multiple myeloma -0.255 3.9e-2 -0.100 2.5e-1 49 Click to see details
GSE26953 Aortic valvular endothelial cells -0.347 4.8e-2 -0.367 3.9e-2 24 Click to see details
GSE28260 Renal cortex and medulla 0.475 5.0e-2 0.412 8.1e-2 13 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.191 1.8e-1 -0.218 1.5e-1 25 Click to see details
GSE38226 Liver fibrosis 0.177 2.2e-1 0.179 2.2e-1 21 Click to see details
GSE28544 Breast cancer -0.154 2.4e-1 -0.275 9.7e-2 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.13 2.9e-1 0.326 8.0e-2 20 Click to see details
GSE21849 B cell lymphoma -0.071 3.6e-1 0.429 1.0e-2 29 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.156 3.8e-1 0.314 2.7e-1 6 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.048 4.1e-1 0.152 2.3e-1 25 Click to see details
GSE21687 Ependynoma primary tumors -0.026 4.2e-1 0.056 3.3e-1 64 Click to see details
GSE19350 CNS germ cell tumors -0.019 4.8e-1 -0.014 4.8e-1 12 Click to see details
GSE17498 Multiple myeloma 0.004 4.9e-1 0.103 2.6e-1 40 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
STAD 0.839 0 0.690 0.03 8 Click to see details
ESCA 0.921 0.01 0.900 0.02 5 Click to see details
KIRC -0.196 0.15 -0.193 0.16 29 Click to see details
KICH -0.35 0.2 -0.548 0.08 8 Click to see details
CHOL -0.314 0.21 -0.300 0.22 9 Click to see details
HNSC 0.766 0.22 0.500 0.33 3 Click to see details
KIRP -0.029 0.47 0.067 0.43 9 Click to see details
THCA -0.045 0.47 0.500 0.2 5 Click to see details
LIHC -0.003 0.49 -0.127 0.19 49 Click to see details
LIHC -0.003 0.49 -0.127 0.19 49 Click to see details
LIHC -0.003 0.49 -0.127 0.19 49 Click to see details
LIHC -0.003 0.49 -0.127 0.19 49 Click to see details
LIHC -0.003 0.49 -0.127 0.19 49 Click to see details
LIHC -0.003 0.49 -0.127 0.19 49 Click to see details
MiRNA Regulatory Network:
Functional analysis:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR) Other evidence
Transcription factor regulation Circular RNA sponge
539 hsa-miR-122-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000012 CYP7A1 cytochrome P450 family 7 subfamily A member 1 3 1
MIRT000364 IGF1R insulin like growth factor 1 receptor 4 3
MIRT000365 SRF serum response factor 4 1
MIRT000663 RAC1 Rac family small GTPase 1 5 2
MIRT000717 RHOA ras homolog family member A 2 2
MIRT003006 CCNG1 cyclin G1 4 4
MIRT003079 GTF2B general transcription factor IIB 2 1
MIRT003080 GYS1 glycogen synthase 1 4 2
MIRT003081 ANK2 ankyrin 2 3 1
MIRT003082 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 3 1
MIRT003083 ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 4 2
MIRT003084 ANXA11 annexin A11 4 2
MIRT003085 ALDOA aldolase, fructose-bisphosphate A 3 2
MIRT003086 RAB6B RAB6B, member RAS oncogene family 3 1
MIRT003087 RAB11FIP1 RAB11 family interacting protein 1 5 3
MIRT003088 FOXP1 forkhead box P1 3 1
MIRT003089 MECP2 methyl-CpG binding protein 2 3 2
MIRT003090 NCAM1 neural cell adhesion molecule 1 4 3
MIRT003091 UBAP2 ubiquitin associated protein 2 3 1
MIRT003092 TBX19 T-box 19 3 1
MIRT003093 AACS acetoacetyl-CoA synthetase 3 1
MIRT003094 DUSP2 dual specificity phosphatase 2 3 1
MIRT003095 ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 3 1
MIRT003097 MAPK11 mitogen-activated protein kinase 11 3 1
MIRT003098 FUNDC2 FUN14 domain containing 2 3 1
MIRT003099 AKT3 AKT serine/threonine kinase 3 3 3
MIRT003100 TPD52L2 tumor protein D52 like 2 4 3
MIRT003102 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 4 2
MIRT003103 G6PC3 glucose-6-phosphatase catalytic subunit 3 4 2
MIRT003104 AP3M2 adaptor related protein complex 3 mu 2 subunit 3 1
MIRT003105 SLC7A1 solute carrier family 7 member 1 4 4
MIRT003106 XPO6 exportin 6 3 1
MIRT003107 FOXJ3 forkhead box J3 3 1
MIRT003108 SLC7A11 solute carrier family 7 member 11 3 1
MIRT003109 TRIB1 tribbles pseudokinase 1 3 1
MIRT003110 EGLN3 egl-9 family hypoxia inducible factor 3 3 1
MIRT003111 NUMBL NUMB like, endocytic adaptor protein 3 1
MIRT003112 ADAM17 ADAM metallopeptidase domain 17 3 5
MIRT003727 DSTYK dual serine/threonine and tyrosine protein kinase 3 2
MIRT003728 FAM117B family with sequence similarity 117 member B 3 1
MIRT004364 BCL2L2 BCL2 like 2 4 2
MIRT004527 PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 2 1
MIRT004879 ADAM10 ADAM metallopeptidase domain 10 5 1
MIRT005782 ACVR1C activin A receptor type 1C 1 1
MIRT006123 PRKRA protein activator of interferon induced protein kinase EIF2AK2 4 1
MIRT006421 WNT1 Wnt family member 1 3 1
MIRT007007 PTPN1 protein tyrosine phosphatase, non-receptor type 1 1 1
MIRT007081 NT5C3A 5'-nucleotidase, cytosolic IIIA 1 1
MIRT007082 P4HA1 prolyl 4-hydroxylase subunit alpha 1 1 1
MIRT007083 ZNF395 zinc finger protein 395 1 1
MIRT007084 SOCS1 suppressor of cytokine signaling 1 1 1
MIRT023217 SSR3 signal sequence receptor subunit 3 1 1
MIRT023218 PHOX2A paired like homeobox 2a 1 1
MIRT023219 DZIP1L DAZ interacting zinc finger protein 1 like 1 1
MIRT023220 GSTM2 glutathione S-transferase mu 2 1 1
MIRT023221 RAI14 retinoic acid induced 14 1 1
MIRT023222 STARD13 StAR related lipid transfer domain containing 13 1 1
MIRT023223 CNN3 calponin 3 1 1
MIRT023224 A2M alpha-2-macroglobulin 1 1
MIRT023225 EFCAB6 EF-hand calcium binding domain 6 1 1
MIRT023226 GLOD4 glyoxalase domain containing 4 1 1
MIRT023227 CALR calreticulin 1 1
MIRT023228 POFUT1 protein O-fucosyltransferase 1 1 1
MIRT023229 PYGO1 pygopus family PHD finger 1 1 1
MIRT023230 CDY2B chromodomain Y-linked 2B 1 1
MIRT023231 CDC42EP3 CDC42 effector protein 3 1 1
MIRT023232 CS citrate synthase 3 3
MIRT023233 RNF170 ring finger protein 170 3 3
MIRT023234 GTF3C6 general transcription factor IIIC subunit 6 1 1
MIRT023235 ZNF321P zinc finger protein 321, pseudogene 1 1
MIRT023236 LAMP1 lysosomal associated membrane protein 1 1 1
MIRT023237 SLC52A2 solute carrier family 52 member 2 1 1
MIRT023238 ZNF658 zinc finger protein 658 1 1
MIRT023239 ATP13A3 ATPase 13A3 1 1
MIRT023240 CPNE5 copine 5 1 1
MIRT023241 KATNAL1 katanin catalytic subunit A1 like 1 1 1
MIRT023242 TMEM136 transmembrane protein 136 1 1
MIRT023243 ATP11A ATPase phospholipid transporting 11A 1 1
MIRT023244 TMEM74 transmembrane protein 74 1 1
MIRT023245 ANKRD10 ankyrin repeat domain 10 1 1
MIRT023246 TBL1XR1 transducin beta like 1 X-linked receptor 1 1 1
MIRT023247 USP10 ubiquitin specific peptidase 10 1 1
MIRT023248 AKAP11 A-kinase anchoring protein 11 1 1
MIRT023249 BACH2 BTB domain and CNC homolog 2 1 1
MIRT023250 HCCS holocytochrome c synthase 1 1
MIRT023251 Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 1 1
MIRT023252 GTDC2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) 1 1
MIRT023253 CTPS1 CTP synthase 1 1 1
MIRT023254 SLC44A1 solute carrier family 44 member 1 1 1
MIRT023255 CLSPN claspin 1 1
MIRT023256 RABGEF1 RAB guanine nucleotide exchange factor 1 1 1
MIRT023257 FBXO7 F-box protein 7 1 1
MIRT023258 NCDN neurochondrin 1 1
MIRT023259 SOX2 SRY-box 2 1 1
MIRT023260 ZNF618 zinc finger protein 618 1 1
MIRT023261 ABLIM1 actin binding LIM protein 1 1 1
MIRT023262 ZBTB4 zinc finger and BTB domain containing 4 1 1
MIRT023263 LUZP1 leucine zipper protein 1 1 1
MIRT023264 NLGN3 neuroligin 3 1 1
MIRT023265 PRR11 proline rich 11 1 1
MIRT023266 HHAT hedgehog acyltransferase 1 1
MIRT023267 UBE2L3 ubiquitin conjugating enzyme E2 L3 1 1
MIRT023268 DNAJC18 DnaJ heat shock protein family (Hsp40) member C18 1 1
MIRT023269 FAM102A family with sequence similarity 102 member A 1 1
MIRT023270 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 1 1
MIRT023271 DENND2C DENN domain containing 2C 1 1
MIRT023272 HMOX1 heme oxygenase 1 3 2
MIRT023273 USP28 ubiquitin specific peptidase 28 1 1
MIRT023274 KRT18 keratin 18 1 1
MIRT023275 BPGM bisphosphoglycerate mutase 1 1
MIRT023276 ZNF233 zinc finger protein 233 1 1
MIRT023277 SLC25A30 solute carrier family 25 member 30 1 1
MIRT023278 ANKRD9 ankyrin repeat domain 9 3 3
MIRT023279 RLN1 relaxin 1 1 1
MIRT023280 DDIT3 DNA damage inducible transcript 3 1 1
MIRT023281 TRIM65 tripartite motif containing 65 1 1
MIRT023282 B4GALT1 beta-1,4-galactosyltransferase 1 1 1
MIRT023283 ANXA7 annexin A7 1 1
MIRT023284 SLC19A2 solute carrier family 19 member 2 1 1
MIRT023285 MARCKS myristoylated alanine rich protein kinase C substrate 1 1
MIRT023286 CLEC11A C-type lectin domain containing 11A 1 1
MIRT023287 CENPF centromere protein F 1 1
MIRT023288 CLDN18 claudin 18 1 1
MIRT023289 PFDN1 prefoldin subunit 1 1 1
MIRT023290 SPAG9 sperm associated antigen 9 1 1
MIRT023291 CEACAM8 carcinoembryonic antigen related cell adhesion molecule 8 1 1
MIRT023292 KRT10 keratin 10 1 1
MIRT023293 SET SET nuclear proto-oncogene 1 1
MIRT023294 SLC11A2 solute carrier family 11 member 2 1 1
MIRT023295 MYCBP MYC binding protein 3 3
MIRT023296 GPHB5 glycoprotein hormone beta 5 1 1
MIRT023297 STAU2 staufen double-stranded RNA binding protein 2 1 1
MIRT023298 NFATC1 nuclear factor of activated T-cells 1 1 1
MIRT023299 ERP29 endoplasmic reticulum protein 29 1 1
MIRT023300 MEP1A meprin A subunit alpha 1 1
MIRT023301 SPTLC1 serine palmitoyltransferase long chain base subunit 1 1 1
MIRT023302 GTF2H2 general transcription factor IIH subunit 2 1 1
MIRT023303 C14orf39 chromosome 14 open reading frame 39 1 1
MIRT023304 UBE2K ubiquitin conjugating enzyme E2 K 1 1
MIRT023305 PPP1R9B protein phosphatase 1 regulatory subunit 9B 1 1
MIRT023306 PSMD10 proteasome 26S subunit, non-ATPase 10 1 1
MIRT023307 CALD1 caldesmon 1 1 1
MIRT023308 TTYH3 tweety family member 3 1 1
MIRT023309 NMNAT2 nicotinamide nucleotide adenylyltransferase 2 1 1
MIRT023310 SCN4B sodium voltage-gated channel beta subunit 4 1 1
MIRT023311 C1orf122 chromosome 1 open reading frame 122 1 1
MIRT023312 PAK1 p21 (RAC1) activated kinase 1 1 1
MIRT023313 DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 1 1
MIRT023314 DMXL1 Dmx like 1 1 1
MIRT023315 ZNF160 zinc finger protein 160 1 1
MIRT023316 CSRP1 cysteine and glycine rich protein 1 1 1
MIRT023317 PHKA1 phosphorylase kinase regulatory subunit alpha 1 1 1
MIRT023318 RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit 1 1
MIRT023319 ANKRD13C ankyrin repeat domain 13C 1 1
MIRT023320 SUCLA2 succinate-CoA ligase ADP-forming beta subunit 1 1
MIRT023321 PEA15 phosphoprotein enriched in astrocytes 15 1 1
MIRT023322 MTPN myotrophin 1 1
MIRT023323 YKT6 YKT6 v-SNARE homolog 1 1
MIRT023324 MOB3B MOB kinase activator 3B 1 1
MIRT023325 FAM118A family with sequence similarity 118 member A 1 1
MIRT023326 ZNF264 zinc finger protein 264 1 1
MIRT023327 HECTD3 HECT domain E3 ubiquitin protein ligase 3 1 1
MIRT023328 BATF2 basic leucine zipper ATF-like transcription factor 2 1 1
MIRT023329 PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha 1 1
MIRT023330 MAPRE1 microtubule associated protein RP/EB family member 1 1 1
MIRT023331 TBC1D22B TBC1 domain family member 22B 1 1
MIRT023332 SLC9A1 solute carrier family 9 member A1 3 3
MIRT023333 NPEPPS aminopeptidase puromycin sensitive 1 1
MIRT023334 BCL2L1 BCL2 like 1 2 1
MIRT023335 OSMR oncostatin M receptor 1 1
MIRT023336 CALU calumenin 1 1
MIRT023337 BRI3BP BRI3 binding protein 1 1
MIRT023338 PSPH phosphoserine phosphatase 1 1
MIRT023339 APMAP adipocyte plasma membrane associated protein 1 1
MIRT023340 WASF1 WAS protein family member 1 1 1
MIRT023341 LCA5 LCA5, lebercilin 1 1
MIRT023342 NODAL nodal growth differentiation factor 1 1
MIRT023343 CASP7 caspase 7 1 1
MIRT023344 CPA3 carboxypeptidase A3 1 1
MIRT023345 PALM paralemmin 1 1
MIRT023346 TCP11 t-complex 11 1 1
MIRT023347 NALCN sodium leak channel, non-selective 1 1
MIRT023348 PLAGL2 PLAG1 like zinc finger 2 1 1
MIRT023349 IDS iduronate 2-sulfatase 3 3
MIRT023350 PARP11 poly(ADP-ribose) polymerase family member 11 1 1
MIRT023351 MAZ MYC associated zinc finger protein 1 1
MIRT023352 CPNE4 copine 4 1 1
MIRT023353 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 1 1
MIRT023354 KRT14 keratin 14 1 1
MIRT023355 DYNC1H1 dynein cytoplasmic 1 heavy chain 1 1 1
MIRT023356 GNL3L G protein nucleolar 3 like 1 1
MIRT023357 HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1 1
MIRT023358 EYA4 EYA transcriptional coactivator and phosphatase 4 1 1
MIRT023359 GNPDA2 glucosamine-6-phosphate deaminase 2 1 1
MIRT023360 BRCA2 BRCA2, DNA repair associated 1 1
MIRT023361 ZSCAN4 zinc finger and SCAN domain containing 4 1 1
MIRT023362 HSPA5 heat shock protein family A (Hsp70) member 5 1 1
MIRT023363 SERAC1 serine active site containing 1 1 1
MIRT023364 SLC15A2 solute carrier family 15 member 2 1 1
MIRT023365 RABIF RAB interacting factor 1 1
MIRT023366 ART3 ADP-ribosyltransferase 3 1 1
MIRT023367 EP400 E1A binding protein p400 1 1
MIRT023368 MT4 metallothionein 4 1 1
MIRT023369 TRAM2 translocation associated membrane protein 2 1 1
MIRT023370 PHPT1 phosphohistidine phosphatase 1 1 1
MIRT023371 KIAA0101 PCNA clamp associated factor 1 1
MIRT023372 VHL von Hippel-Lindau tumor suppressor 1 1
MIRT023373 IFNA1 interferon alpha 1 1 1
MIRT023374 FSTL3 follistatin like 3 1 1
MIRT023375 PHF14 PHD finger protein 14 1 1
MIRT023376 ZCCHC2 zinc finger CCHC-type containing 2 1 1
MIRT023377 GSTM3 glutathione S-transferase mu 3 1 1
MIRT023378 DCTN5 dynactin subunit 5 1 1
MIRT023379 CHST3 carbohydrate sulfotransferase 3 1 1
MIRT023380 HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 1 1
MIRT023381 ADO 2-aminoethanethiol dioxygenase 1 1
MIRT023382 POMZP3 POM121 and ZP3 fusion 1 1
MIRT023383 CHST12 carbohydrate sulfotransferase 12 1 1
MIRT023384 ARSB arylsulfatase B 1 1
MIRT023385 ATP7A ATPase copper transporting alpha 1 1
MIRT023386 PMP22 peripheral myelin protein 22 1 1
MIRT023387 TGFBRAP1 transforming growth factor beta receptor associated protein 1 1 1
MIRT023388 ORC2 origin recognition complex subunit 2 1 1
MIRT023389 CREB1 cAMP responsive element binding protein 1 1 1
MIRT023390 CD83 CD83 molecule 1 1
MIRT023391 TOB2 transducer of ERBB2, 2 3 5
MIRT023392 LRP11 LDL receptor related protein 11 1 1
MIRT023393 MPV17 MPV17, mitochondrial inner membrane protein 1 1
MIRT023394 TRIM29 tripartite motif containing 29 1 1
MIRT023395 OSBP2 oxysterol binding protein 2 1 1
MIRT023396 PKM pyruvate kinase, muscle 6 4
MIRT023397 FOXK2 forkhead box K2 3 3
MIRT023398 CLIC4 chloride intracellular channel 4 5 6
MIRT023399 ST6GALNAC4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 1 1
MIRT023400 SMURF2 SMAD specific E3 ubiquitin protein ligase 2 1 1
MIRT023401 LMNB2 lamin B2 3 5
MIRT023402 BAX BCL2 associated X, apoptosis regulator 2 2
MIRT023403 CDK4 cyclin dependent kinase 4 3 3
MIRT054362 Cux1 cut-like homeobox 1 1 1
MIRT074336 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT109185 VMA21 VMA21, vacuolar ATPase assembly factor 2 4
MIRT324745 ACER2 alkaline ceramidase 2 2 2
MIRT325564 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT438005 MEF2D myocyte enhancer factor 2D 1 2
MIRT438206 TGFB1 transforming growth factor beta 1 1 1
MIRT438639 AXL AXL receptor tyrosine kinase 1 1
MIRT438655 NOD2 nucleotide binding oligomerization domain containing 2 3 1
MIRT438734 FUT8 fucosyltransferase 8 3 1
MIRT449879 CYP3A5 cytochrome P450 family 3 subfamily A member 5 2 2
MIRT451716 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT453274 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT454113 MRPL52 mitochondrial ribosomal protein L52 2 2
MIRT454232 OSBPL10 oxysterol binding protein like 10 2 15
MIRT454344 CDKL1 cyclin dependent kinase like 1 2 2
MIRT455826 ZSWIM1 zinc finger SWIM-type containing 1 2 3
MIRT459903 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 12
MIRT461654 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT461934 TNFSF14 TNF superfamily member 14 2 2
MIRT463834 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT468615 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT469456 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT469637 RAD21 RAD21 cohesin complex component 2 6
MIRT473432 MDM4 MDM4, p53 regulator 2 2
MIRT473872 MAFK MAF bZIP transcription factor K 2 6
MIRT476861 FHL2 four and a half LIM domains 2 2 4
MIRT476893 FBXO21 F-box protein 21 2 2
MIRT479880 CCDC43 coiled-coil domain containing 43 2 2
MIRT488848 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT491164 LRP3 LDL receptor related protein 3 2 2
MIRT497662 PRMT3 protein arginine methyltransferase 3 2 2
MIRT499314 ZNF485 zinc finger protein 485 2 10
MIRT499759 CIRH1A UTP4, small subunit processome component 2 10
MIRT500014 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT501090 SLC7A5 solute carrier family 7 member 5 2 4
MIRT509646 ZNF354B zinc finger protein 354B 2 10
MIRT509945 TOMM70A translocase of outer mitochondrial membrane 70 2 6
MIRT510320 SLC2A3 solute carrier family 2 member 3 2 4
MIRT515505 GTF2F1 general transcription factor IIF subunit 1 2 2
MIRT516410 COPA coatomer protein complex subunit alpha 2 2
MIRT517861 NCAPD2 non-SMC condensin I complex subunit D2 2 4
MIRT522558 MCAM melanoma cell adhesion molecule 2 4
MIRT523525 GLUL glutamate-ammonia ligase 2 2
MIRT523764 FBXO27 F-box protein 27 2 4
MIRT524517 CDK19 cyclin dependent kinase 19 2 2
MIRT524753 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT529366 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT531189 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531639 C19orf52 translocase of inner mitochondrial membrane 29 2 4
MIRT531913 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT532678 PATZ1 POZ/BTB and AT hook containing zinc finger 1 2 2
MIRT533115 YIPF4 Yip1 domain family member 4 2 4
MIRT534740 RBM47 RNA binding motif protein 47 2 2
MIRT535471 PARVB parvin beta 2 4
MIRT536742 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT537237 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2 2
MIRT539523 ABCF1 ATP binding cassette subfamily F member 1 2 4
MIRT540438 RBM43 RNA binding motif protein 43 2 2
MIRT542982 ERC1 ELKS/RAB6-interacting/CAST family member 1 2 2
MIRT544674 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT549514 HDDC2 HD domain containing 2 2 2
MIRT549663 ORC6 origin recognition complex subunit 6 2 4
MIRT555420 PPIC peptidylprolyl isomerase C 2 2
MIRT564701 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT570046 PKNOX1 PBX/knotted 1 homeobox 1 2 2
MIRT570257 PRSS16 protease, serine 16 2 2
MIRT571143 HM13 histocompatibility minor 13 2 2
MIRT575202 Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 2 2
MIRT575282 Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 2 2
MIRT575302 Osbpl10 oxysterol binding protein-like 10 2 9
MIRT575323 Fbxo6 F-box protein 6 2 2
MIRT575377 Ang angiogenin, ribonuclease, RNase A family, 5 2 3
MIRT575614 Zswim1 zinc finger SWIM-type containing 1 2 3
MIRT575671 Map1b microtubule-associated protein 1B 2 2
MIRT607065 POM121L7 POM121 transmembrane nucleoporin like 7 pseudogene 2 2
MIRT607490 HEBP2 heme binding protein 2 2 2
MIRT607522 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT607655 BTN3A2 butyrophilin subfamily 3 member A2 2 2
MIRT607795 RHBDL2 rhomboid like 2 2 2
MIRT607842 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT607927 ANG angiogenin 2 3
MIRT607966 SNX22 sorting nexin 22 2 2
MIRT608074 ZFP14 ZFP14 zinc finger protein 2 2
MIRT608141 SYAP1 synapse associated protein 1 2 2
MIRT612620 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT617444 CCS copper chaperone for superoxide dismutase 2 2
MIRT617552 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT618772 HLA-E major histocompatibility complex, class I, E 2 2
MIRT618926 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT619247 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT620091 YME1L1 YME1 like 1 ATPase 2 2
MIRT620483 XKR6 XK related 6 2 2
MIRT620570 WBSCR27 methyltransferase like 27 2 4
MIRT622977 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT623169 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT624165 DGKE diacylglycerol kinase epsilon 2 2
MIRT625268 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT625396 AKR7L aldo-keto reductase family 7 like (gene/pseudogene) 2 2
MIRT625694 OPTN optineurin 2 2
MIRT626093 MKLN1 muskelin 1 2 2
MIRT626431 CHDH choline dehydrogenase 2 2
MIRT627013 FIG4 FIG4 phosphoinositide 5-phosphatase 2 2
MIRT627077 SF3A1 splicing factor 3a subunit 1 2 2
MIRT627140 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT627347 TSHZ2 teashirt zinc finger homeobox 2 2 2
MIRT627420 THAP2 THAP domain containing 2 2 2
MIRT627441 TAS2R5 taste 2 receptor member 5 2 2
MIRT628078 KAT7 lysine acetyltransferase 7 2 4
MIRT628276 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT629094 F2RL1 F2R like trypsin receptor 1 2 2
MIRT629236 CINP cyclin dependent kinase 2 interacting protein 2 2
MIRT629286 UNC13A unc-13 homolog A 2 2
MIRT629407 ADM2 adrenomedullin 2 2 2
MIRT629584 RFC2 replication factor C subunit 2 2 2
MIRT629635 WDR31 WD repeat domain 31 2 2
MIRT629874 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT629984 NARS asparaginyl-tRNA synthetase 2 2
MIRT630043 TERF2 telomeric repeat binding factor 2 2 2
MIRT630061 NIP7 NIP7, nucleolar pre-rRNA processing protein 2 2
MIRT630127 ARHGEF5 Rho guanine nucleotide exchange factor 5 2 2
MIRT630155 ZBTB8A zinc finger and BTB domain containing 8A 2 2
MIRT630252 SMTNL2 smoothelin like 2 2 2
MIRT630278 PSMB5 proteasome subunit beta 5 2 2
MIRT630347 NKAP NFKB activating protein 2 2
MIRT630497 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT631264 CENPM centromere protein M 2 2
MIRT631403 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT632470 RPS15A ribosomal protein S15a 2 2
MIRT632596 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632994 DUSP18 dual specificity phosphatase 18 2 2
MIRT633082 CXorf21 chromosome X open reading frame 21 2 2
MIRT633239 ZNF573 zinc finger protein 573 2 2
MIRT633286 SLC1A5 solute carrier family 1 member 5 2 2
MIRT633536 PGBD5 piggyBac transposable element derived 5 2 2
MIRT634338 SGOL1 shugoshin 1 2 2
MIRT634600 KIAA1919 major facilitator superfamily domain containing 4B 2 2
MIRT635050 MYH11 myosin heavy chain 11 2 2
MIRT635236 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT635322 BMS1 BMS1, ribosome biogenesis factor 2 2
MIRT636268 RNF157 ring finger protein 157 2 2
MIRT636450 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT636516 FMN1 formin 1 2 2
MIRT636755 SLC16A5 solute carrier family 16 member 5 2 2
MIRT637134 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT637188 ROMO1 reactive oxygen species modulator 1 2 2
MIRT637287 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT637532 RGS9BP regulator of G protein signaling 9 binding protein 2 2
MIRT637693 CEP89 centrosomal protein 89 2 2
MIRT637788 OLA1 Obg like ATPase 1 2 2
MIRT637925 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT638449 PLXDC2 plexin domain containing 2 2 2
MIRT640871 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT642643 PTGR2 prostaglandin reductase 2 2 2
MIRT643082 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT643123 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644236 SLC35E3 solute carrier family 35 member E3 2 2
MIRT644665 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT645092 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT645993 ACP6 acid phosphatase 6, lysophosphatidic 2 2
MIRT646508 FAM217B family with sequence similarity 217 member B 2 2
MIRT647013 ADCY2 adenylate cyclase 2 2 2
MIRT647095 SEC23B Sec23 homolog B, coat complex II component 2 2
MIRT647714 NFX1 nuclear transcription factor, X-box binding 1 2 4
MIRT648040 FADS6 fatty acid desaturase 6 2 2
MIRT648510 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT648865 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT649182 DNPEP aspartyl aminopeptidase 2 2
MIRT649660 TEP1 telomerase associated protein 1 2 2
MIRT651465 XIAP X-linked inhibitor of apoptosis 2 2
MIRT652398 TMEM40 transmembrane protein 40 2 2
MIRT653691 SLC25A33 solute carrier family 25 member 33 2 2
MIRT654122 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654577 PXMP4 peroxisomal membrane protein 4 2 2
MIRT656470 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT658905 DPY19L4 dpy-19 like 4 2 2
MIRT660878 ADRBK2 G protein-coupled receptor kinase 3 2 4
MIRT661101 SPIB Spi-B transcription factor 2 2
MIRT661238 ARL17B ADP ribosylation factor like GTPase 17B 2 2
MIRT661291 LIN52 lin-52 DREAM MuvB core complex component 2 2
MIRT662235 PGBD4 piggyBac transposable element derived 4 2 2
MIRT662544 MTAP methylthioadenosine phosphorylase 2 2
MIRT662736 LRRC3C leucine rich repeat containing 3C 2 2
MIRT662844 OMD osteomodulin 2 2
MIRT662907 MED18 mediator complex subunit 18 2 2
MIRT662956 JPH2 junctophilin 2 2 2
MIRT663340 ZNF74 zinc finger protein 74 2 2
MIRT663496 IYD iodotyrosine deiodinase 2 2
MIRT663523 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT663542 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663903 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT663973 ZNF786 zinc finger protein 786 2 2
MIRT664350 C16orf45 chromosome 16 open reading frame 45 2 2
MIRT664417 TIGD6 tigger transposable element derived 6 2 2
MIRT664468 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT664957 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT664970 TDRD1 tudor domain containing 1 2 2
MIRT665199 ESF1 ESF1 nucleolar pre-rRNA processing protein homolog 2 2
MIRT665359 XKR4 XK related 4 2 2
MIRT665454 WDR17 WD repeat domain 17 2 2
MIRT665486 VPS53 VPS53, GARP complex subunit 2 2
MIRT666078 SSTR2 somatostatin receptor 2 2 2
MIRT666258 SLC31A1 solute carrier family 31 member 1 2 2
MIRT666324 SLC16A10 solute carrier family 16 member 10 2 2
MIRT666486 SBNO1 strawberry notch homolog 1 2 2
MIRT666696 RBM23 RNA binding motif protein 23 2 2
MIRT666712 RBL1 RB transcriptional corepressor like 1 2 2
MIRT666762 RAB10 RAB10, member RAS oncogene family 2 2
MIRT666931 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT667226 NFE2L1 nuclear factor, erythroid 2 like 1 2 2
MIRT667359 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT667474 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT667558 LRAT lecithin retinol acyltransferase 2 2
MIRT667748 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT668088 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT668119 GK5 glycerol kinase 5 (putative) 2 2
MIRT668166 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668346 STXBP2 syntaxin binding protein 2 2 2
MIRT668509 ESYT2 extended synaptotagmin 2 2 2
MIRT669291 C17orf85 nuclear cap binding subunit 3 2 2
MIRT669547 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT669778 CNDP1 carnosine dipeptidase 1 2 2
MIRT669858 BROX BRO1 domain and CAAX motif containing 2 4
MIRT670017 TECPR1 tectonin beta-propeller repeat containing 1 2 2
MIRT670177 CCDC142 coiled-coil domain containing 142 2 2
MIRT671107 ZNF841 zinc finger protein 841 2 2
MIRT671351 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 2
MIRT671476 FLYWCH2 FLYWCH family member 2 2 2
MIRT671492 SLC38A9 solute carrier family 38 member 9 2 2
MIRT671554 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT671925 PLEKHS1 pleckstrin homology domain containing S1 2 4
MIRT672196 F2 coagulation factor II, thrombin 2 2
MIRT672217 DCAF7 DDB1 and CUL4 associated factor 7 2 2
MIRT672252 SIK2 salt inducible kinase 2 2 2
MIRT672290 GP2 glycoprotein 2 2 2
MIRT672430 POLR2D RNA polymerase II subunit D 2 2
MIRT672597 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT672901 KRBA2 KRAB-A domain containing 2 2 2
MIRT672958 ZNF655 zinc finger protein 655 2 2
MIRT673096 SYNPO2L synaptopodin 2 like 2 2
MIRT673171 TMEM56 transmembrane protein 56 2 2
MIRT673251 INO80 INO80 complex subunit 2 2
MIRT673296 RNF19B ring finger protein 19B 2 2
MIRT673574 KDELC2 KDEL motif containing 2 2 2
MIRT673586 KIF1C kinesin family member 1C 2 2
MIRT673737 TCF23 transcription factor 23 2 2
MIRT673767 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674215 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT674283 NAGK N-acetylglucosamine kinase 2 2
MIRT674338 KCMF1 potassium channel modulatory factor 1 2 2
MIRT674517 PRR23A proline rich 23A 2 2
MIRT675100 SNTB2 syntrophin beta 2 2 2
MIRT675144 MOGAT1 monoacylglycerol O-acyltransferase 1 2 4
MIRT675223 CLK4 CDC like kinase 4 2 2
MIRT675263 ZNF431 zinc finger protein 431 2 2
MIRT675577 WWC1 WW and C2 domain containing 1 2 2
MIRT676025 C9orf69 transmembrane protein 250 2 2
MIRT676430 PLEKHM3 pleckstrin homology domain containing M3 2 2
MIRT676560 VSIG1 V-set and immunoglobulin domain containing 1 2 2
MIRT676596 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT678576 TMEM168 transmembrane protein 168 2 2
MIRT678756 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT680344 ZNF281 zinc finger protein 281 2 2
MIRT680467 C3 complement C3 2 2
MIRT682826 FLG2 filaggrin family member 2 2 2
MIRT682881 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT684404 TMEM180 major facilitator superfamily domain containing 13A 2 2
MIRT685275 KIAA1143 KIAA1143 2 2
MIRT686061 KCNA7 potassium voltage-gated channel subfamily A member 7 2 2
MIRT687526 NASP nuclear autoantigenic sperm protein 2 2
MIRT691760 BCL2L15 BCL2 like 15 2 2
MIRT693890 C3orf62 chromosome 3 open reading frame 62 2 2
MIRT699342 SLC35E1 solute carrier family 35 member E1 2 2
MIRT699909 RUNDC1 RUN domain containing 1 2 2
MIRT700536 PTPDC1 protein tyrosine phosphatase domain containing 1 2 2
MIRT701807 MRPS25 mitochondrial ribosomal protein S25 2 2
MIRT702174 LYRM4 LYR motif containing 4 2 2
MIRT706205 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706659 RNF216 ring finger protein 216 2 2
MIRT706682 COL13A1 collagen type XIII alpha 1 chain 2 2
MIRT706705 GPR155 G protein-coupled receptor 155 2 2
MIRT706777 ANKRD36 ankyrin repeat domain 36 2 2
MIRT706844 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706863 MAFF MAF bZIP transcription factor F 2 2
MIRT706896 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT706916 THAP6 THAP domain containing 6 2 2
MIRT706962 FANCC Fanconi anemia complementation group C 2 2
MIRT706980 XPO5 exportin 5 2 2
MIRT707015 RRP36 ribosomal RNA processing 36 2 2
MIRT707032 ACTR5 ARP5 actin related protein 5 homolog 2 2
MIRT707072 MED29 mediator complex subunit 29 2 2
MIRT709368 SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2 2
MIRT720092 SPTLC3 serine palmitoyltransferase long chain base subunit 3 2 2
MIRT721330 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT724198 MED7 mediator complex subunit 7 2 2
MIRT725403 KIF6 kinesin family member 6 2 2
MIRT733035 COL4A2 collagen type IV alpha 2 chain 1 0
MIRT733036 COL26A1 collagen type XXVI alpha 1 chain 1 0
MIRT733426 PLK1 polo like kinase 1 3 0
MIRT734484 PLD1 phospholipase D1 3 0
MIRT736044 CBL Cbl proto-oncogene 3 0
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