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miRTarBase - #MIRT673096 -
pre-miRNA Information
pre-miRNA hsa-mir-122   
Genomic Coordinates chr18: 58451074 - 58451158
Synonyms MIR122A, MIRN122, MIRN122A, hsa-mir-122, miRNA122, miRNA122A, MIR122
Description Homo sapiens miR-122 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-122-5p
Sequence 15| UGGAGUGUGACAAUGGUGUUUG |36
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 18 + 58451091 29233923 MiREDiBase
C-to-U 11 18 + 58451098 28550310 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1258166649 1 dbSNP
rs1426570658 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles

Circulating MicroRNA Expression Profiling
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SYNPO2L   
Synonyms -
Description synaptopodin 2 like
Transcript NM_001114133   
Other Transcripts NM_024875   
Expression
Putative miRNA Targets on SYNPO2L
3'UTR of SYNPO2L
(miRNA target sites are highlighted)		 
>SYNPO2L|NM_001114133|3'UTR
   1 ACAGGCACAGGTCCCAGGACCAAGGAGAGGTGGAACATCCAGTTCCTAAAGTTGCTTCTCCTACCCTATCCCATCCCCTG
  81 TCACGCATCTGGAAGCTAAATTGCCTCCTGCCAGAGATGGTTTCCAAGTTGATGTCCCCTTCCCCCACCTTCCTCCTCAC
 161 TCTCTACCTCCCTGCCGCTTTCCAACCAAGTATGTCTGCTTTGGTATCTTTGCCTCTCTTTGTCTCTGCATTTCCTTTCC
 241 TGGATCTCTGTCTTTATTTCCAGGCTTCTCCACCCATATTCCTCCACAGATCTCTCTTCCTTGACATTTGTGCTTTTCTC
 321 CCTGGGCCTCATTTTAATGTTCAGTGAGAAGTAAACAGAGCAGAAGTGACCACTGGGACTTCAGGCAAGAAGCTCACCAC
 401 CAGGCACACAGCAAAGGGACTGAACTGACCCCTGTTTGCACTAAGCCACCCCCACCCCCCACTCTGCTTTCCCAAGCTTG
 481 ACTGGCATATACCTAGGCCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCTCTTCCGTCTAAGGCATGAA
 561 TAAGAGGGGAGGTCAAAATAAAGACCCAATCTGAGGCCGGGCACGGTGGCTCACGCCGGTAATCCCAGCACTTTGGGAGG
 641 CCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCATTTCCACTAAAAATAC
 721 AAAAAATTAGCTGGGCGTGGTGGCGAGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATGGCATGAACCT
 801 GGAAGGCGGAGCTTGCAGTGAGCTGAGATTGCGCCACTGCACTCCAGCCTGGGCGACGGAGCGAGACTCTGTCTCAAAAC
 881 AAACAAACAAACAAAAGACCCAATCTGAGTCTTATCGTTGTACTGATAGAAGGGTCAGATATCCCCACATGGAGTTGAGT
 961 GGGAGAAAGAGATTCACTAGAGAATAACTCCTTAGAGACCAATGTCTGTAGCAGGTGTACAGCATCTTGTGAAAGTTATG
1041 GAGCATGAAAAGACTGAAGGGCCAGGACAGTTTGCATGGGCTGAGTTATACCAGCTAGACCAGGAATAGAACAAAGAATT
1121 CTATACCTCAGGATTTCAAAAAGTTAGCAACTTGAGAGGCCAGTGCTGAGCAACCCAGTACCCAGGAAATGAAAAAAAGA
1201 AAGAAAATTCCCTCCGAGAATGAACAAATCATTGGCTTCATTGCCTCATGAGCTTGAGAGAAAGGAGAAGAGAGCCAGAG
1281 TGTGGCAAGTGAGGCCAAAATCAGAAGCATGGCAGAAATGAGTGTAAGTGATTGAGCCACAGACAGAAGTGTGGCGAGGG
1361 ACAATGCCATATTGGGAGAAGGTAAAGTTGAGTAACAAGAAACCAACCGTGTGTGAGAGGGGGATTGGAAAAAAATTTGA
1441 GGGAGAAGAATGTTAGAATGGAAGGGAATGATGGTGGAAGGGAGGTGTGAGGGTGTGTGCTGAGTGTTGAAAGAACGGTT
1521 GGTGTCTGTGTGATTTTCCTTGAGTCTGTTCTTCAGTGTGTCTTCTGCAGCTTGCCATGACTGCCTGGGAAAGAGTAGGG
1601 AAATACCCAGAGCCAAAACCTCCTTTCAGTCCCACCCCATCCCTCAAAACCCCAGCTATTGCTTCTTTTCAGCTTCAGGT
1681 CCTGATCTCCAATCTTAGTATGGACTCCCTTCTCACCAAGACCACCACCAGCTACGTTTGCTGTGTAATCTGGAAAGTGA
1761 TAATTTCCTTTGCTTGTTGGGTGTGAGTCACAATACTTTGGTTTGTGCACAAGAATAAATTTATGCCCCATACCTTC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions (Predicted by miRanda)
IDDuplex structurePositionScoreMFE
1 
miRNA  3' guuUGUGGUAACAGUGUGAGGu 5'
             :|:||| |   :|||||| 
Target 5' attGCGCCACT---GCACTCCa 3'
 		828 - 846 136.00 -17.50
2 
miRNA  3' guuuGUGGUAACAGUGUGAGGu 5'
              ||||     ||:|:||| 
Target 5' tctcCACC-----CATATTCCt 3'
 		267 - 283 117.00 -11.80
3 
miRNA  3' guuuGUGGUAACA-GUGUGAGGu 5'
              |||| |  | | |||||: 
Target 5' ccccCACCTTCCTCCTCACTCTc 3'
 		142 - 164 110.00 -11.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30490493 15 COSMIC
COSN30190615 27 COSMIC
COSN31494091 64 COSMIC
COSN30171291 72 COSMIC
COSN30499582 105 COSMIC
COSN31547997 116 COSMIC
COSN31514448 153 COSMIC
COSN31567440 246 COSMIC
COSN26440260 310 COSMIC
COSN20092128 348 COSMIC
COSN25475760 399 COSMIC
COSN24540908 454 COSMIC
COSN20107262 499 COSMIC
COSN20107266 500 COSMIC
COSN28693316 841 COSMIC
COSN28643791 868 COSMIC
COSN28201940 871 COSMIC
COSN5253713 886 COSMIC
COSN31547643 890 COSMIC
COSN26580977 963 COSMIC
COSN25441468 991 COSMIC
COSN5883476 1004 COSMIC
COSN26581459 1031 COSMIC
COSN26668033 1091 COSMIC
COSN31516583 1437 COSMIC
COSN1500339 1479 COSMIC
COSN30544429 1518 COSMIC
COSN31529323 1546 COSMIC
COSN28858030 1589 COSMIC
COSN30123972 1623 COSMIC
COSN1122392 1642 COSMIC
COSN30544036 1656 COSMIC
COSN18713652 1678 COSMIC
COSN30164802 1681 COSMIC
COSN1122390 1741 COSMIC
COSN30129019 1775 COSMIC
COSN26435903 1784 COSMIC
COSN28187135 1809 COSMIC
rs3740293 335 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1216962456 5 dbSNP
rs189798321 8 dbSNP
rs754863833 9 dbSNP
rs1206091329 13 dbSNP
rs200943721 15 dbSNP
rs1189285955 16 dbSNP
rs1324426955 27 dbSNP
rs766117288 29 dbSNP
rs561222652 30 dbSNP
rs746136240 31 dbSNP
rs1360135153 32 dbSNP
rs41280406 33 dbSNP
rs529926811 51 dbSNP
rs765862668 55 dbSNP
rs900507997 60 dbSNP
rs760246909 65 dbSNP
rs942038874 66 dbSNP
rs1357063932 71 dbSNP
rs35459518 79 dbSNP
rs1017325699 80 dbSNP
rs1007655346 84 dbSNP
rs376406191 85 dbSNP
rs1301510095 97 dbSNP
rs867419711 98 dbSNP
rs1333158012 101 dbSNP
rs1207757267 103 dbSNP
rs909312958 108 dbSNP
rs566427671 110 dbSNP
rs1465305079 119 dbSNP
rs1207959667 127 dbSNP
rs890152684 129 dbSNP
rs983488240 132 dbSNP
rs1447682910 138 dbSNP
rs1403769576 139 dbSNP
rs1051854715 146 dbSNP
rs562628569 147 dbSNP
rs1174415644 166 dbSNP
rs143952122 174 dbSNP
rs534999959 177 dbSNP
rs1414561328 178 dbSNP
rs929489959 179 dbSNP
rs558549174 185 dbSNP
rs992374084 186 dbSNP
rs1037878849 190 dbSNP
rs749481949 191 dbSNP
rs1437947160 196 dbSNP
rs1293824282 197 dbSNP
rs959583358 198 dbSNP
rs1482063279 199 dbSNP
rs1289992249 203 dbSNP
rs942144626 204 dbSNP
rs915995421 213 dbSNP
rs1266143993 223 dbSNP
rs1471867868 228 dbSNP
rs1033930629 239 dbSNP
rs767093147 249 dbSNP
rs938750689 258 dbSNP
rs967724685 264 dbSNP
rs12570798 273 dbSNP
rs1021134644 287 dbSNP
rs548332100 292 dbSNP
rs890966287 298 dbSNP
rs1029466573 310 dbSNP
rs913786997 328 dbSNP
rs3740293 335 dbSNP
rs1309417227 344 dbSNP
rs1350936791 347 dbSNP
rs957872605 355 dbSNP
rs1017835932 366 dbSNP
rs774613764 374 dbSNP
rs954605300 389 dbSNP
rs1228746701 395 dbSNP
rs1030041650 404 dbSNP
rs993126841 413 dbSNP
rs1280781749 420 dbSNP
rs898089334 447 dbSNP
rs572931233 450 dbSNP
rs1220595513 454 dbSNP
rs770039469 454 dbSNP
rs1483623292 460 dbSNP
rs1181897428 461 dbSNP
rs554375437 493 dbSNP
rs1203357991 498 dbSNP
rs942055761 499 dbSNP
rs887756952 500 dbSNP
rs1047820943 502 dbSNP
rs1412472460 503 dbSNP
rs894670710 504 dbSNP
rs1056358614 505 dbSNP
rs1170138715 505 dbSNP
rs1428640026 508 dbSNP
rs938817026 509 dbSNP
rs138687876 510 dbSNP
rs907239377 512 dbSNP
rs1448697872 516 dbSNP
rs929355428 528 dbSNP
rs1041708665 530 dbSNP
rs1448247191 531 dbSNP
rs1360560522 533 dbSNP
rs1243863509 534 dbSNP
rs1317890577 534 dbSNP
rs918094985 536 dbSNP
rs1456256879 537 dbSNP
rs1343160781 538 dbSNP
rs769203006 538 dbSNP
rs1160627929 539 dbSNP
rs1166270721 540 dbSNP
rs1180061665 540 dbSNP
rs1187450850 540 dbSNP
rs1189954054 540 dbSNP
rs1204623059 540 dbSNP
rs1211501141 540 dbSNP
rs1237382348 540 dbSNP
rs1270522185 540 dbSNP
rs1271368632 540 dbSNP
rs1442315594 540 dbSNP
rs1444440558 540 dbSNP
rs1448529242 540 dbSNP
rs1491446952 540 dbSNP
rs56147683 540 dbSNP
rs57745482 540 dbSNP
rs59162775 540 dbSNP
rs796899631 540 dbSNP
rs1227068084 541 dbSNP
rs913837907 541 dbSNP
rs946021874 541 dbSNP
rs140171142 542 dbSNP
rs1211078671 545 dbSNP
rs1248126117 546 dbSNP
rs938192254 547 dbSNP
rs926893958 554 dbSNP
rs979677001 555 dbSNP
rs1378999819 566 dbSNP
rs34172607 569 dbSNP
rs1171798384 570 dbSNP
rs1239433187 571 dbSNP
rs1020577430 579 dbSNP
rs1458782578 580 dbSNP
rs1321086413 586 dbSNP
rs987895068 589 dbSNP
rs910420985 595 dbSNP
rs955141230 598 dbSNP
rs192799507 599 dbSNP
rs996705628 600 dbSNP
rs954488962 602 dbSNP
rs538980638 604 dbSNP
rs1288817152 605 dbSNP
rs1321790205 608 dbSNP
rs1017277939 610 dbSNP
rs146617579 614 dbSNP
rs1202840049 615 dbSNP
rs571826543 617 dbSNP
rs1047687605 618 dbSNP
rs1006505799 624 dbSNP
rs1266537184 627 dbSNP
rs547019950 631 dbSNP
rs528467338 642 dbSNP
rs1433695129 643 dbSNP
rs1284892804 644 dbSNP
rs1056458441 647 dbSNP
rs938188552 648 dbSNP
rs567610381 651 dbSNP
rs1392917962 652 dbSNP
rs1044370205 658 dbSNP
rs946953823 659 dbSNP
rs914148048 661 dbSNP
rs907298558 662 dbSNP
rs142904487 672 dbSNP
rs531001409 673 dbSNP
rs188178616 682 dbSNP
rs975161439 689 dbSNP
rs1356378981 690 dbSNP
rs1054378526 692 dbSNP
rs1448907037 693 dbSNP
rs936642656 718 dbSNP
rs910421514 720 dbSNP
rs985991990 732 dbSNP
rs1189469490 734 dbSNP
rs370099084 736 dbSNP
rs1458442894 737 dbSNP
rs550782594 744 dbSNP
rs1016730116 745 dbSNP
rs923036150 746 dbSNP
rs1005891279 748 dbSNP
rs1272015278 749 dbSNP
rs1373006563 762 dbSNP
rs532492859 763 dbSNP
rs1390191642 768 dbSNP
rs1227271269 769 dbSNP
rs971831635 781 dbSNP
rs1025515292 790 dbSNP
rs993485209 793 dbSNP
rs1205349051 795 dbSNP
rs961781805 807 dbSNP
rs896479908 808 dbSNP
rs1015975530 810 dbSNP
rs1202143838 813 dbSNP
rs1256766243 824 dbSNP
rs1424530532 830 dbSNP
rs1183077863 831 dbSNP
rs1383388366 832 dbSNP
rs565204466 833 dbSNP
rs984822413 837 dbSNP
rs1384585901 838 dbSNP
rs41280404 841 dbSNP
rs1460759126 844 dbSNP
rs1034986044 850 dbSNP
rs1293515595 853 dbSNP
rs182419981 854 dbSNP
rs1043933187 855 dbSNP
rs144469305 857 dbSNP
rs1294364899 858 dbSNP
rs373158284 858 dbSNP
rs1235125720 860 dbSNP
rs762544582 861 dbSNP
rs560910376 862 dbSNP
rs149246701 863 dbSNP
rs1431581590 868 dbSNP
rs893220160 869 dbSNP
rs1466292560 870 dbSNP
rs796420303 871 dbSNP
rs1191749005 877 dbSNP
rs1054464191 896 dbSNP
rs1419069148 896 dbSNP
rs1178712387 897 dbSNP
rs574977812 903 dbSNP
rs1469770875 909 dbSNP
rs1335286918 911 dbSNP
rs1390251142 913 dbSNP
rs780398864 915 dbSNP
rs756890889 916 dbSNP
rs1388084082 922 dbSNP
rs757441751 926 dbSNP
rs889054605 943 dbSNP
rs975572068 950 dbSNP
rs1483147615 952 dbSNP
rs374112958 960 dbSNP
rs1269909625 963 dbSNP
rs140338614 965 dbSNP
rs1230417057 967 dbSNP
rs933235488 973 dbSNP
rs1485019964 977 dbSNP
rs923130903 984 dbSNP
rs1036193209 997 dbSNP
rs1480295095 1001 dbSNP
rs909617200 1003 dbSNP
rs538846240 1020 dbSNP
rs542756076 1021 dbSNP
rs984012980 1026 dbSNP
rs763633046 1030 dbSNP
rs369876802 1039 dbSNP
rs1157739728 1041 dbSNP
rs1342886798 1043 dbSNP
rs1025547872 1046 dbSNP
rs1243902424 1050 dbSNP
rs1286781455 1059 dbSNP
rs1402867545 1060 dbSNP
rs1290202319 1061 dbSNP
rs1351051744 1068 dbSNP
rs1223082000 1072 dbSNP
rs1014099372 1073 dbSNP
rs960695918 1084 dbSNP
rs958591760 1085 dbSNP
rs1409604698 1090 dbSNP
rs1371397824 1092 dbSNP
rs1300176879 1094 dbSNP
rs1292771912 1100 dbSNP
rs926960513 1103 dbSNP
rs578225876 1113 dbSNP
rs41280402 1116 dbSNP
rs535279982 1118 dbSNP
rs1177084692 1126 dbSNP
rs1405224874 1137 dbSNP
rs1481350701 1158 dbSNP
rs1061859 1159 dbSNP
rs905313941 1164 dbSNP
rs1181110997 1168 dbSNP
rs1472827367 1177 dbSNP
rs1020450108 1183 dbSNP
rs1198410424 1190 dbSNP
rs1309631118 1190 dbSNP
rs1022782349 1194 dbSNP
rs1277666684 1199 dbSNP
rs371668773 1199 dbSNP
rs554269336 1199 dbSNP
rs1011101824 1201 dbSNP
rs1256022186 1213 dbSNP
rs1230084773 1215 dbSNP
rs879280246 1216 dbSNP
rs111909088 1227 dbSNP
rs368702396 1232 dbSNP
rs1287076788 1245 dbSNP
rs889809499 1249 dbSNP
rs1228152468 1259 dbSNP
rs1204489950 1264 dbSNP
rs1231669379 1266 dbSNP
rs1473526986 1268 dbSNP
rs1183684759 1274 dbSNP
rs934192671 1276 dbSNP
rs1384011458 1280 dbSNP
rs1442433041 1284 dbSNP
rs900847883 1285 dbSNP
rs1390614876 1288 dbSNP
rs1039406100 1289 dbSNP
rs942359131 1290 dbSNP
rs1326836644 1294 dbSNP
rs754860741 1295 dbSNP
rs1448576117 1296 dbSNP
rs1337505294 1302 dbSNP
rs1382063605 1305 dbSNP
rs1309384057 1307 dbSNP
rs1244117618 1309 dbSNP
rs909657500 1310 dbSNP
rs1378752010 1319 dbSNP
rs1340586844 1322 dbSNP
rs549365010 1324 dbSNP
rs997472730 1326 dbSNP
rs373369032 1334 dbSNP
rs115251193 1335 dbSNP
rs138190774 1336 dbSNP
rs992710111 1356 dbSNP
rs556890647 1358 dbSNP
rs908980667 1359 dbSNP
rs114598671 1361 dbSNP
rs368848312 1372 dbSNP
rs1185167946 1374 dbSNP
rs1426959872 1390 dbSNP
rs1414991652 1396 dbSNP
rs1422817641 1404 dbSNP
rs1405490697 1408 dbSNP
rs532214042 1409 dbSNP
rs1322873149 1411 dbSNP
rs1256427486 1415 dbSNP
rs565042235 1428 dbSNP
rs1268822656 1437 dbSNP
rs1184898105 1439 dbSNP
rs1347519468 1442 dbSNP
rs1034676746 1444 dbSNP
rs539046548 1451 dbSNP
rs146989764 1468 dbSNP
rs969780080 1475 dbSNP
rs767162212 1487 dbSNP
rs560755376 1489 dbSNP
rs1022386773 1491 dbSNP
rs1010956741 1495 dbSNP
rs1480622728 1501 dbSNP
rs1198687593 1502 dbSNP
rs1427099378 1503 dbSNP
rs988952602 1504 dbSNP
rs957513687 1507 dbSNP
rs542193874 1516 dbSNP
rs141233100 1517 dbSNP
rs563036947 1518 dbSNP
rs1316081417 1528 dbSNP
rs1333234652 1528 dbSNP
rs1400410529 1533 dbSNP
rs901447762 1533 dbSNP
rs1405914892 1554 dbSNP
rs148116168 1560 dbSNP
rs1454623429 1565 dbSNP
rs1040356474 1579 dbSNP
rs578112986 1596 dbSNP
rs1230729821 1602 dbSNP
rs553506857 1606 dbSNP
rs751269863 1607 dbSNP
rs1214442952 1613 dbSNP
rs759858329 1621 dbSNP
rs764349323 1623 dbSNP
rs1470232464 1628 dbSNP
rs1349303360 1630 dbSNP
rs954148812 1634 dbSNP
rs1353803078 1635 dbSNP
rs1291573101 1637 dbSNP
rs1490469126 1638 dbSNP
rs888073933 1639 dbSNP
rs1266427054 1640 dbSNP
rs1167740243 1642 dbSNP
rs1048164028 1646 dbSNP
rs1182379591 1652 dbSNP
rs34529973 1654 dbSNP
rs1419805035 1659 dbSNP
rs766372958 1665 dbSNP
rs998150773 1667 dbSNP
rs764409025 1671 dbSNP
rs901771809 1678 dbSNP
rs1349831922 1687 dbSNP
rs1185761859 1688 dbSNP
rs761148867 1692 dbSNP
rs1251180482 1693 dbSNP
rs1202545552 1698 dbSNP
rs1004784871 1699 dbSNP
rs1309325448 1700 dbSNP
rs775560608 1701 dbSNP
rs1245483468 1702 dbSNP
rs918324241 1704 dbSNP
rs1316919383 1708 dbSNP
rs1453044197 1709 dbSNP
rs767455524 1720 dbSNP
rs1372529359 1728 dbSNP
rs772404601 1730 dbSNP
rs1443817221 1733 dbSNP
rs992645136 1735 dbSNP
rs938516495 1736 dbSNP
rs1048877361 1743 dbSNP
rs1221228522 1746 dbSNP
rs1289352310 1746 dbSNP
rs1483902436 1759 dbSNP
rs1196354937 1760 dbSNP
rs1249732135 1765 dbSNP
rs535025760 1768 dbSNP
rs1188667697 1772 dbSNP
rs1387121222 1776 dbSNP
rs1445490125 1780 dbSNP
rs980393182 1781 dbSNP
rs905573780 1782 dbSNP
rs1045382093 1786 dbSNP
rs1299302178 1791 dbSNP
rs574261746 1792 dbSNP
rs567448773 1793 dbSNP
rs949692902 1796 dbSNP
rs1382824950 1799 dbSNP
rs117050535 1803 dbSNP
rs989048974 1805 dbSNP
rs1344138731 1806 dbSNP
rs989576861 1811 dbSNP
rs1250482216 1813 dbSNP
rs143732128 1823 dbSNP
rs537431294 1829 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
IDDuplex structurePosition
1 
miRNA  3' guuUGUGGUAACAGUGUGAGGu 5'
             :|:||| |   :|||||| 
Target 5' auuGCGCCACU---GCACUCC- 3'
 		19 - 36
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000372873.4 | 3UTR | AGCUUGCAGUGAGCUGAGAUUGCGCCACUGCACUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21849 B cell lymphoma -0.497 3.0e-3 0.100 3.0e-1 29 Click to see details
GSE17306 Multiple myeloma -0.276 2.7e-2 -0.114 2.2e-1 49 Click to see details
GSE28260 Renal cortex and medulla -0.533 3.0e-2 -0.582 1.8e-2 13 Click to see details
GSE27834 Pluripotent stem cells -0.395 6.5e-2 -0.421 5.2e-2 16 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.183 1.9e-1 0.178 2.0e-1 25 Click to see details
GSE28544 Breast cancer 0.156 2.3e-1 0.223 1.5e-1 24 Click to see details
GSE17498 Multiple myeloma 0.115 2.4e-1 -0.046 3.9e-1 40 Click to see details
GSE26953 Aortic valvular endothelial cells 0.127 2.8e-1 0.151 2.4e-1 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.124 2.9e-1 -0.073 3.7e-1 23 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.276 3.0e-1 -0.143 3.9e-1 6 Click to see details
GSE21687 Ependynoma primary tumors 0.043 3.7e-1 0.088 2.4e-1 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.062 4.0e-1 0.111 3.2e-1 20 Click to see details
GSE32688 Pancreatic cancer 0.047 4.0e-1 0.061 3.7e-1 32 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.051 4.0e-1 0.037 4.3e-1 25 Click to see details
GSE14794 Lymphoblastoid cells -0.007 4.7e-1 0.073 2.5e-1 90 Click to see details
GSE38226 Liver fibrosis 0.006 4.9e-1 0.192 2.0e-1 21 Click to see details
GSE19350 CNS germ cell tumors -0.004 5.0e-1 0.245 2.2e-1 12 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LIHC -0.516 0 -0.362 0.01 49 Click to see details
CHOL 0.551 0.06 0.700 0.02 9 Click to see details
STAD 0.455 0.13 0.381 0.18 8 Click to see details
KICH -0.34 0.2 -0.167 0.35 8 Click to see details
HNSC 0.688 0.26 0.500 0.33 3 Click to see details
THCA -0.343 0.29 -0.400 0.25 5 Click to see details
ESCA 0.262 0.34 -0.300 0.31 5 Click to see details
KIRC -0.059 0.38 -0.161 0.2 29 Click to see details
KIRP 0.08 0.42 0.100 0.4 9 Click to see details
KIRP 0.08 0.42 0.100 0.4 9 Click to see details
KIRP 0.08 0.42 0.100 0.4 9 Click to see details
KIRP 0.08 0.42 0.100 0.4 9 Click to see details
KIRP 0.08 0.42 0.100 0.4 9 Click to see details
KIRP 0.08 0.42 0.100 0.4 9 Click to see details
MiRNA Regulatory Network:
Functional analysis:
Strong evidence (reporter assay, western blot, qRT-PCR or qPCR) Other evidence
Transcription factor regulation Circular RNA sponge
539 hsa-miR-122-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000012 CYP7A1 cytochrome P450 family 7 subfamily A member 1 3 1
MIRT000364 IGF1R insulin like growth factor 1 receptor 4 3
MIRT000365 SRF serum response factor 4 1
MIRT000663 RAC1 Rac family small GTPase 1 5 2
MIRT000717 RHOA ras homolog family member A 2 2
MIRT003006 CCNG1 cyclin G1 4 4
MIRT003079 GTF2B general transcription factor IIB 2 1
MIRT003080 GYS1 glycogen synthase 1 4 2
MIRT003081 ANK2 ankyrin 2 3 1
MIRT003082 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 3 1
MIRT003083 ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 4 2
MIRT003084 ANXA11 annexin A11 4 2
MIRT003085 ALDOA aldolase, fructose-bisphosphate A 3 2
MIRT003086 RAB6B RAB6B, member RAS oncogene family 3 1
MIRT003087 RAB11FIP1 RAB11 family interacting protein 1 5 3
MIRT003088 FOXP1 forkhead box P1 3 1
MIRT003089 MECP2 methyl-CpG binding protein 2 3 2
MIRT003090 NCAM1 neural cell adhesion molecule 1 4 3
MIRT003091 UBAP2 ubiquitin associated protein 2 3 1
MIRT003092 TBX19 T-box 19 3 1
MIRT003093 AACS acetoacetyl-CoA synthetase 3 1
MIRT003094 DUSP2 dual specificity phosphatase 2 3 1
MIRT003095 ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 3 1
MIRT003097 MAPK11 mitogen-activated protein kinase 11 3 1
MIRT003098 FUNDC2 FUN14 domain containing 2 3 1
MIRT003099 AKT3 AKT serine/threonine kinase 3 3 3
MIRT003100 TPD52L2 tumor protein D52 like 2 4 3
MIRT003102 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 4 2
MIRT003103 G6PC3 glucose-6-phosphatase catalytic subunit 3 4 2
MIRT003104 AP3M2 adaptor related protein complex 3 mu 2 subunit 3 1
MIRT003105 SLC7A1 solute carrier family 7 member 1 4 4
MIRT003106 XPO6 exportin 6 3 1
MIRT003107 FOXJ3 forkhead box J3 3 1
MIRT003108 SLC7A11 solute carrier family 7 member 11 3 1
MIRT003109 TRIB1 tribbles pseudokinase 1 3 1
MIRT003110 EGLN3 egl-9 family hypoxia inducible factor 3 3 1
MIRT003111 NUMBL NUMB like, endocytic adaptor protein 3 1
MIRT003112 ADAM17 ADAM metallopeptidase domain 17 3 5
MIRT003727 DSTYK dual serine/threonine and tyrosine protein kinase 3 2
MIRT003728 FAM117B family with sequence similarity 117 member B 3 1
MIRT004364 BCL2L2 BCL2 like 2 4 2
MIRT004527 PRKAB1 protein kinase AMP-activated non-catalytic subunit beta 1 2 1
MIRT004879 ADAM10 ADAM metallopeptidase domain 10 5 1
MIRT005782 ACVR1C activin A receptor type 1C 1 1
MIRT006123 PRKRA protein activator of interferon induced protein kinase EIF2AK2 4 1
MIRT006421 WNT1 Wnt family member 1 3 1
MIRT007007 PTPN1 protein tyrosine phosphatase, non-receptor type 1 1 1
MIRT007081 NT5C3A 5'-nucleotidase, cytosolic IIIA 1 1
MIRT007082 P4HA1 prolyl 4-hydroxylase subunit alpha 1 1 1
MIRT007083 ZNF395 zinc finger protein 395 1 1
MIRT007084 SOCS1 suppressor of cytokine signaling 1 1 1
MIRT023217 SSR3 signal sequence receptor subunit 3 1 1
MIRT023218 PHOX2A paired like homeobox 2a 1 1
MIRT023219 DZIP1L DAZ interacting zinc finger protein 1 like 1 1
MIRT023220 GSTM2 glutathione S-transferase mu 2 1 1
MIRT023221 RAI14 retinoic acid induced 14 1 1
MIRT023222 STARD13 StAR related lipid transfer domain containing 13 1 1
MIRT023223 CNN3 calponin 3 1 1
MIRT023224 A2M alpha-2-macroglobulin 1 1
MIRT023225 EFCAB6 EF-hand calcium binding domain 6 1 1
MIRT023226 GLOD4 glyoxalase domain containing 4 1 1
MIRT023227 CALR calreticulin 1 1
MIRT023228 POFUT1 protein O-fucosyltransferase 1 1 1
MIRT023229 PYGO1 pygopus family PHD finger 1 1 1
MIRT023230 CDY2B chromodomain Y-linked 2B 1 1
MIRT023231 CDC42EP3 CDC42 effector protein 3 1 1
MIRT023232 CS citrate synthase 3 3
MIRT023233 RNF170 ring finger protein 170 3 3
MIRT023234 GTF3C6 general transcription factor IIIC subunit 6 1 1
MIRT023235 ZNF321P zinc finger protein 321, pseudogene 1 1
MIRT023236 LAMP1 lysosomal associated membrane protein 1 1 1
MIRT023237 SLC52A2 solute carrier family 52 member 2 1 1
MIRT023238 ZNF658 zinc finger protein 658 1 1
MIRT023239 ATP13A3 ATPase 13A3 1 1
MIRT023240 CPNE5 copine 5 1 1
MIRT023241 KATNAL1 katanin catalytic subunit A1 like 1 1 1
MIRT023242 TMEM136 transmembrane protein 136 1 1
MIRT023243 ATP11A ATPase phospholipid transporting 11A 1 1
MIRT023244 TMEM74 transmembrane protein 74 1 1
MIRT023245 ANKRD10 ankyrin repeat domain 10 1 1
MIRT023246 TBL1XR1 transducin beta like 1 X-linked receptor 1 1 1
MIRT023247 USP10 ubiquitin specific peptidase 10 1 1
MIRT023248 AKAP11 A-kinase anchoring protein 11 1 1
MIRT023249 BACH2 BTB domain and CNC homolog 2 1 1
MIRT023250 HCCS holocytochrome c synthase 1 1
MIRT023251 Slc7a1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 1 1
MIRT023252 GTDC2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) 1 1
MIRT023253 CTPS1 CTP synthase 1 1 1
MIRT023254 SLC44A1 solute carrier family 44 member 1 1 1
MIRT023255 CLSPN claspin 1 1
MIRT023256 RABGEF1 RAB guanine nucleotide exchange factor 1 1 1
MIRT023257 FBXO7 F-box protein 7 1 1
MIRT023258 NCDN neurochondrin 1 1
MIRT023259 SOX2 SRY-box 2 1 1
MIRT023260 ZNF618 zinc finger protein 618 1 1
MIRT023261 ABLIM1 actin binding LIM protein 1 1 1
MIRT023262 ZBTB4 zinc finger and BTB domain containing 4 1 1
MIRT023263 LUZP1 leucine zipper protein 1 1 1
MIRT023264 NLGN3 neuroligin 3 1 1
MIRT023265 PRR11 proline rich 11 1 1
MIRT023266 HHAT hedgehog acyltransferase 1 1
MIRT023267 UBE2L3 ubiquitin conjugating enzyme E2 L3 1 1
MIRT023268 DNAJC18 DnaJ heat shock protein family (Hsp40) member C18 1 1
MIRT023269 FAM102A family with sequence similarity 102 member A 1 1
MIRT023270 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 1 1
MIRT023271 DENND2C DENN domain containing 2C 1 1
MIRT023272 HMOX1 heme oxygenase 1 3 2
MIRT023273 USP28 ubiquitin specific peptidase 28 1 1
MIRT023274 KRT18 keratin 18 1 1
MIRT023275 BPGM bisphosphoglycerate mutase 1 1
MIRT023276 ZNF233 zinc finger protein 233 1 1
MIRT023277 SLC25A30 solute carrier family 25 member 30 1 1
MIRT023278 ANKRD9 ankyrin repeat domain 9 3 3
MIRT023279 RLN1 relaxin 1 1 1
MIRT023280 DDIT3 DNA damage inducible transcript 3 1 1
MIRT023281 TRIM65 tripartite motif containing 65 1 1
MIRT023282 B4GALT1 beta-1,4-galactosyltransferase 1 1 1
MIRT023283 ANXA7 annexin A7 1 1
MIRT023284 SLC19A2 solute carrier family 19 member 2 1 1
MIRT023285 MARCKS myristoylated alanine rich protein kinase C substrate 1 1
MIRT023286 CLEC11A C-type lectin domain containing 11A 1 1
MIRT023287 CENPF centromere protein F 1 1
MIRT023288 CLDN18 claudin 18 1 1
MIRT023289 PFDN1 prefoldin subunit 1 1 1
MIRT023290 SPAG9 sperm associated antigen 9 1 1
MIRT023291 CEACAM8 carcinoembryonic antigen related cell adhesion molecule 8 1 1
MIRT023292 KRT10 keratin 10 1 1
MIRT023293 SET SET nuclear proto-oncogene 1 1
MIRT023294 SLC11A2 solute carrier family 11 member 2 1 1
MIRT023295 MYCBP MYC binding protein 3 3
MIRT023296 GPHB5 glycoprotein hormone beta 5 1 1
MIRT023297 STAU2 staufen double-stranded RNA binding protein 2 1 1
MIRT023298 NFATC1 nuclear factor of activated T-cells 1 1 1
MIRT023299 ERP29 endoplasmic reticulum protein 29 1 1
MIRT023300 MEP1A meprin A subunit alpha 1 1
MIRT023301 SPTLC1 serine palmitoyltransferase long chain base subunit 1 1 1
MIRT023302 GTF2H2 general transcription factor IIH subunit 2 1 1
MIRT023303 C14orf39 chromosome 14 open reading frame 39 1 1
MIRT023304 UBE2K ubiquitin conjugating enzyme E2 K 1 1
MIRT023305 PPP1R9B protein phosphatase 1 regulatory subunit 9B 1 1
MIRT023306 PSMD10 proteasome 26S subunit, non-ATPase 10 1 1
MIRT023307 CALD1 caldesmon 1 1 1
MIRT023308 TTYH3 tweety family member 3 1 1
MIRT023309 NMNAT2 nicotinamide nucleotide adenylyltransferase 2 1 1
MIRT023310 SCN4B sodium voltage-gated channel beta subunit 4 1 1
MIRT023311 C1orf122 chromosome 1 open reading frame 122 1 1
MIRT023312 PAK1 p21 (RAC1) activated kinase 1 1 1
MIRT023313 DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 1 1
MIRT023314 DMXL1 Dmx like 1 1 1
MIRT023315 ZNF160 zinc finger protein 160 1 1
MIRT023316 CSRP1 cysteine and glycine rich protein 1 1 1
MIRT023317 PHKA1 phosphorylase kinase regulatory subunit alpha 1 1 1
MIRT023318 RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit 1 1
MIRT023319 ANKRD13C ankyrin repeat domain 13C 1 1
MIRT023320 SUCLA2 succinate-CoA ligase ADP-forming beta subunit 1 1
MIRT023321 PEA15 phosphoprotein enriched in astrocytes 15 1 1
MIRT023322 MTPN myotrophin 1 1
MIRT023323 YKT6 YKT6 v-SNARE homolog 1 1
MIRT023324 MOB3B MOB kinase activator 3B 1 1
MIRT023325 FAM118A family with sequence similarity 118 member A 1 1
MIRT023326 ZNF264 zinc finger protein 264 1 1
MIRT023327 HECTD3 HECT domain E3 ubiquitin protein ligase 3 1 1
MIRT023328 BATF2 basic leucine zipper ATF-like transcription factor 2 1 1
MIRT023329 PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha 1 1
MIRT023330 MAPRE1 microtubule associated protein RP/EB family member 1 1 1
MIRT023331 TBC1D22B TBC1 domain family member 22B 1 1
MIRT023332 SLC9A1 solute carrier family 9 member A1 3 3
MIRT023333 NPEPPS aminopeptidase puromycin sensitive 1 1
MIRT023334 BCL2L1 BCL2 like 1 2 1
MIRT023335 OSMR oncostatin M receptor 1 1
MIRT023336 CALU calumenin 1 1
MIRT023337 BRI3BP BRI3 binding protein 1 1
MIRT023338 PSPH phosphoserine phosphatase 1 1
MIRT023339 APMAP adipocyte plasma membrane associated protein 1 1
MIRT023340 WASF1 WAS protein family member 1 1 1
MIRT023341 LCA5 LCA5, lebercilin 1 1
MIRT023342 NODAL nodal growth differentiation factor 1 1
MIRT023343 CASP7 caspase 7 1 1
MIRT023344 CPA3 carboxypeptidase A3 1 1
MIRT023345 PALM paralemmin 1 1
MIRT023346 TCP11 t-complex 11 1 1
MIRT023347 NALCN sodium leak channel, non-selective 1 1
MIRT023348 PLAGL2 PLAG1 like zinc finger 2 1 1
MIRT023349 IDS iduronate 2-sulfatase 3 3
MIRT023350 PARP11 poly(ADP-ribose) polymerase family member 11 1 1
MIRT023351 MAZ MYC associated zinc finger protein 1 1
MIRT023352 CPNE4 copine 4 1 1
MIRT023353 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 1 1
MIRT023354 KRT14 keratin 14 1 1
MIRT023355 DYNC1H1 dynein cytoplasmic 1 heavy chain 1 1 1
MIRT023356 GNL3L G protein nucleolar 3 like 1 1
MIRT023357 HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1 1
MIRT023358 EYA4 EYA transcriptional coactivator and phosphatase 4 1 1
MIRT023359 GNPDA2 glucosamine-6-phosphate deaminase 2 1 1
MIRT023360 BRCA2 BRCA2, DNA repair associated 1 1
MIRT023361 ZSCAN4 zinc finger and SCAN domain containing 4 1 1
MIRT023362 HSPA5 heat shock protein family A (Hsp70) member 5 1 1
MIRT023363 SERAC1 serine active site containing 1 1 1
MIRT023364 SLC15A2 solute carrier family 15 member 2 1 1
MIRT023365 RABIF RAB interacting factor 1 1
MIRT023366 ART3 ADP-ribosyltransferase 3 1 1
MIRT023367 EP400 E1A binding protein p400 1 1
MIRT023368 MT4 metallothionein 4 1 1
MIRT023369 TRAM2 translocation associated membrane protein 2 1 1
MIRT023370 PHPT1 phosphohistidine phosphatase 1 1 1
MIRT023371 KIAA0101 PCNA clamp associated factor 1 1
MIRT023372 VHL von Hippel-Lindau tumor suppressor 1 1
MIRT023373 IFNA1 interferon alpha 1 1 1
MIRT023374 FSTL3 follistatin like 3 1 1
MIRT023375 PHF14 PHD finger protein 14 1 1
MIRT023376 ZCCHC2 zinc finger CCHC-type containing 2 1 1
MIRT023377 GSTM3 glutathione S-transferase mu 3 1 1
MIRT023378 DCTN5 dynactin subunit 5 1 1
MIRT023379 CHST3 carbohydrate sulfotransferase 3 1 1
MIRT023380 HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 1 1
MIRT023381 ADO 2-aminoethanethiol dioxygenase 1 1
MIRT023382 POMZP3 POM121 and ZP3 fusion 1 1
MIRT023383 CHST12 carbohydrate sulfotransferase 12 1 1
MIRT023384 ARSB arylsulfatase B 1 1
MIRT023385 ATP7A ATPase copper transporting alpha 1 1
MIRT023386 PMP22 peripheral myelin protein 22 1 1
MIRT023387 TGFBRAP1 transforming growth factor beta receptor associated protein 1 1 1
MIRT023388 ORC2 origin recognition complex subunit 2 1 1
MIRT023389 CREB1 cAMP responsive element binding protein 1 1 1
MIRT023390 CD83 CD83 molecule 1 1
MIRT023391 TOB2 transducer of ERBB2, 2 3 5
MIRT023392 LRP11 LDL receptor related protein 11 1 1
MIRT023393 MPV17 MPV17, mitochondrial inner membrane protein 1 1
MIRT023394 TRIM29 tripartite motif containing 29 1 1
MIRT023395 OSBP2 oxysterol binding protein 2 1 1
MIRT023396 PKM pyruvate kinase, muscle 6 4
MIRT023397 FOXK2 forkhead box K2 3 3
MIRT023398 CLIC4 chloride intracellular channel 4 5 6
MIRT023399 ST6GALNAC4 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 1 1
MIRT023400 SMURF2 SMAD specific E3 ubiquitin protein ligase 2 1 1
MIRT023401 LMNB2 lamin B2 3 5
MIRT023402 BAX BCL2 associated X, apoptosis regulator 2 2
MIRT023403 CDK4 cyclin dependent kinase 4 3 3
MIRT054362 Cux1 cut-like homeobox 1 1 1
MIRT074336 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT109185 VMA21 VMA21, vacuolar ATPase assembly factor 2 4
MIRT324745 ACER2 alkaline ceramidase 2 2 2
MIRT325564 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT438005 MEF2D myocyte enhancer factor 2D 1 2
MIRT438206 TGFB1 transforming growth factor beta 1 1 1
MIRT438639 AXL AXL receptor tyrosine kinase 1 1
MIRT438655 NOD2 nucleotide binding oligomerization domain containing 2 3 1
MIRT438734 FUT8 fucosyltransferase 8 3 1
MIRT449879 CYP3A5 cytochrome P450 family 3 subfamily A member 5 2 2
MIRT451716 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT453274 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT454113 MRPL52 mitochondrial ribosomal protein L52 2 2
MIRT454232 OSBPL10 oxysterol binding protein like 10 2 15
MIRT454344 CDKL1 cyclin dependent kinase like 1 2 2
MIRT455826 ZSWIM1 zinc finger SWIM-type containing 1 2 3
MIRT459903 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 12
MIRT461654 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT461934 TNFSF14 TNF superfamily member 14 2 2
MIRT463834 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT468615 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT469456 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT469637 RAD21 RAD21 cohesin complex component 2 6
MIRT473432 MDM4 MDM4, p53 regulator 2 2
MIRT473872 MAFK MAF bZIP transcription factor K 2 6
MIRT476861 FHL2 four and a half LIM domains 2 2 4
MIRT476893 FBXO21 F-box protein 21 2 2
MIRT479880 CCDC43 coiled-coil domain containing 43 2 2
MIRT488848 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT491164 LRP3 LDL receptor related protein 3 2 2
MIRT497662 PRMT3 protein arginine methyltransferase 3 2 2
MIRT499314 ZNF485 zinc finger protein 485 2 10
MIRT499759 CIRH1A UTP4, small subunit processome component 2 10
MIRT500014 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT501090 SLC7A5 solute carrier family 7 member 5 2 4
MIRT509646 ZNF354B zinc finger protein 354B 2 10
MIRT509945 TOMM70A translocase of outer mitochondrial membrane 70 2 6
MIRT510320 SLC2A3 solute carrier family 2 member 3 2 4
MIRT515505 GTF2F1 general transcription factor IIF subunit 1 2 2
MIRT516410 COPA coatomer protein complex subunit alpha 2 2
MIRT517861 NCAPD2 non-SMC condensin I complex subunit D2 2 4
MIRT522558 MCAM melanoma cell adhesion molecule 2 4
MIRT523525 GLUL glutamate-ammonia ligase 2 2
MIRT523764 FBXO27 F-box protein 27 2 4
MIRT524517 CDK19 cyclin dependent kinase 19 2 2
MIRT524753 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT529366 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT531189 SIGLEC12 sialic acid binding Ig like lectin 12 (gene/pseudogene) 2 2
MIRT531639 C19orf52 translocase of inner mitochondrial membrane 29 2 4
MIRT531913 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT532678 PATZ1 POZ/BTB and AT hook containing zinc finger 1 2 2
MIRT533115 YIPF4 Yip1 domain family member 4 2 4
MIRT534740 RBM47 RNA binding motif protein 47 2 2
MIRT535471 PARVB parvin beta 2 4
MIRT536742 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT537237 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2 2
MIRT539523 ABCF1 ATP binding cassette subfamily F member 1 2 4
MIRT540438 RBM43 RNA binding motif protein 43 2 2
MIRT542982 ERC1 ELKS/RAB6-interacting/CAST family member 1 2 2
MIRT544674 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT549514 HDDC2 HD domain containing 2 2 2
MIRT549663 ORC6 origin recognition complex subunit 6 2 4
MIRT555420 PPIC peptidylprolyl isomerase C 2 2
MIRT564701 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT570046 PKNOX1 PBX/knotted 1 homeobox 1 2 2
MIRT570257 PRSS16 protease, serine 16 2 2
MIRT571143 HM13 histocompatibility minor 13 2 2
MIRT575202 Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 2 2
MIRT575282 Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 2 2
MIRT575302 Osbpl10 oxysterol binding protein-like 10 2 9
MIRT575323 Fbxo6 F-box protein 6 2 2
MIRT575377 Ang angiogenin, ribonuclease, RNase A family, 5 2 3
MIRT575614 Zswim1 zinc finger SWIM-type containing 1 2 3
MIRT575671 Map1b microtubule-associated protein 1B 2 2
MIRT607065 POM121L7 POM121 transmembrane nucleoporin like 7 pseudogene 2 2
MIRT607490 HEBP2 heme binding protein 2 2 2
MIRT607522 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT607655 BTN3A2 butyrophilin subfamily 3 member A2 2 2
MIRT607795 RHBDL2 rhomboid like 2 2 2
MIRT607842 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT607927 ANG angiogenin 2 3
MIRT607966 SNX22 sorting nexin 22 2 2
MIRT608074 ZFP14 ZFP14 zinc finger protein 2 2
MIRT608141 SYAP1 synapse associated protein 1 2 2
MIRT612620 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT617444 CCS copper chaperone for superoxide dismutase 2 2
MIRT617552 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT618772 HLA-E major histocompatibility complex, class I, E 2 2
MIRT618926 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT619247 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT620091 YME1L1 YME1 like 1 ATPase 2 2
MIRT620483 XKR6 XK related 6 2 2
MIRT620570 WBSCR27 methyltransferase like 27 2 4
MIRT622977 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT623169 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT624165 DGKE diacylglycerol kinase epsilon 2 2
MIRT625268 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT625396 AKR7L aldo-keto reductase family 7 like (gene/pseudogene) 2 2
MIRT625694 OPTN optineurin 2 2
MIRT626093 MKLN1 muskelin 1 2 2
MIRT626431 CHDH choline dehydrogenase 2 2
MIRT627013 FIG4 FIG4 phosphoinositide 5-phosphatase 2 2
MIRT627077 SF3A1 splicing factor 3a subunit 1 2 2
MIRT627140 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT627347 TSHZ2 teashirt zinc finger homeobox 2 2 2
MIRT627420 THAP2 THAP domain containing 2 2 2
MIRT627441 TAS2R5 taste 2 receptor member 5 2 2
MIRT628078 KAT7 lysine acetyltransferase 7 2 4
MIRT628276 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT629094 F2RL1 F2R like trypsin receptor 1 2 2
MIRT629236 CINP cyclin dependent kinase 2 interacting protein 2 2
MIRT629286 UNC13A unc-13 homolog A 2 2
MIRT629407 ADM2 adrenomedullin 2 2 2
MIRT629584 RFC2 replication factor C subunit 2 2 2
MIRT629635 WDR31 WD repeat domain 31 2 2
MIRT629874 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT629984 NARS asparaginyl-tRNA synthetase 2 2
MIRT630043 TERF2 telomeric repeat binding factor 2 2 2
MIRT630061 NIP7 NIP7, nucleolar pre-rRNA processing protein 2 2
MIRT630127 ARHGEF5 Rho guanine nucleotide exchange factor 5 2 2
MIRT630155 ZBTB8A zinc finger and BTB domain containing 8A 2 2
MIRT630252 SMTNL2 smoothelin like 2 2 2
MIRT630278 PSMB5 proteasome subunit beta 5 2 2
MIRT630347 NKAP NFKB activating protein 2 2
MIRT630497 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT631264 CENPM centromere protein M 2 2
MIRT631403 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT632470 RPS15A ribosomal protein S15a 2 2
MIRT632596 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632994 DUSP18 dual specificity phosphatase 18 2 2
MIRT633082 CXorf21 chromosome X open reading frame 21 2 2
MIRT633239 ZNF573 zinc finger protein 573 2 2
MIRT633286 SLC1A5 solute carrier family 1 member 5 2 2
MIRT633536 PGBD5 piggyBac transposable element derived 5 2 2
MIRT634338 SGOL1 shugoshin 1 2 2
MIRT634600 KIAA1919 major facilitator superfamily domain containing 4B 2 2
MIRT635050 MYH11 myosin heavy chain 11 2 2
MIRT635236 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT635322 BMS1 BMS1, ribosome biogenesis factor 2 2
MIRT636268 RNF157 ring finger protein 157 2 2
MIRT636450 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT636516 FMN1 formin 1 2 2
MIRT636755 SLC16A5 solute carrier family 16 member 5 2 2
MIRT637134 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT637188 ROMO1 reactive oxygen species modulator 1 2 2
MIRT637287 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT637532 RGS9BP regulator of G protein signaling 9 binding protein 2 2
MIRT637693 CEP89 centrosomal protein 89 2 2
MIRT637788 OLA1 Obg like ATPase 1 2 2
MIRT637925 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT638449 PLXDC2 plexin domain containing 2 2 2
MIRT640871 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT642643 PTGR2 prostaglandin reductase 2 2 2
MIRT643082 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT643123 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT644236 SLC35E3 solute carrier family 35 member E3 2 2
MIRT644665 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT645092 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT645993 ACP6 acid phosphatase 6, lysophosphatidic 2 2
MIRT646508 FAM217B family with sequence similarity 217 member B 2 2
MIRT647013 ADCY2 adenylate cyclase 2 2 2
MIRT647095 SEC23B Sec23 homolog B, coat complex II component 2 2
MIRT647714 NFX1 nuclear transcription factor, X-box binding 1 2 4
MIRT648040 FADS6 fatty acid desaturase 6 2 2
MIRT648510 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT648865 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT649182 DNPEP aspartyl aminopeptidase 2 2
MIRT649660 TEP1 telomerase associated protein 1 2 2
MIRT651465 XIAP X-linked inhibitor of apoptosis 2 2
MIRT652398 TMEM40 transmembrane protein 40 2 2
MIRT653691 SLC25A33 solute carrier family 25 member 33 2 2
MIRT654122 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654577 PXMP4 peroxisomal membrane protein 4 2 2
MIRT656470 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 2
MIRT658905 DPY19L4 dpy-19 like 4 2 2
MIRT660878 ADRBK2 G protein-coupled receptor kinase 3 2 4
MIRT661101 SPIB Spi-B transcription factor 2 2
MIRT661238 ARL17B ADP ribosylation factor like GTPase 17B 2 2
MIRT661291 LIN52 lin-52 DREAM MuvB core complex component 2 2
MIRT662235 PGBD4 piggyBac transposable element derived 4 2 2
MIRT662544 MTAP methylthioadenosine phosphorylase 2 2
MIRT662736 LRRC3C leucine rich repeat containing 3C 2 2
MIRT662844 OMD osteomodulin 2 2
MIRT662907 MED18 mediator complex subunit 18 2 2
MIRT662956 JPH2 junctophilin 2 2 2
MIRT663340 ZNF74 zinc finger protein 74 2 2
MIRT663496 IYD iodotyrosine deiodinase 2 2
MIRT663523 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT663542 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663903 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT663973 ZNF786 zinc finger protein 786 2 2
MIRT664350 C16orf45 chromosome 16 open reading frame 45 2 2
MIRT664417 TIGD6 tigger transposable element derived 6 2 2
MIRT664468 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT664957 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT664970 TDRD1 tudor domain containing 1 2 2
MIRT665199 ESF1 ESF1 nucleolar pre-rRNA processing protein homolog 2 2
MIRT665359 XKR4 XK related 4 2 2
MIRT665454 WDR17 WD repeat domain 17 2 2
MIRT665486 VPS53 VPS53, GARP complex subunit 2 2
MIRT666078 SSTR2 somatostatin receptor 2 2 2
MIRT666258 SLC31A1 solute carrier family 31 member 1 2 2
MIRT666324 SLC16A10 solute carrier family 16 member 10 2 2
MIRT666486 SBNO1 strawberry notch homolog 1 2 2
MIRT666696 RBM23 RNA binding motif protein 23 2 2
MIRT666712 RBL1 RB transcriptional corepressor like 1 2 2
MIRT666762 RAB10 RAB10, member RAS oncogene family 2 2
MIRT666931 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT667226 NFE2L1 nuclear factor, erythroid 2 like 1 2 2
MIRT667359 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT667474 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT667558 LRAT lecithin retinol acyltransferase 2 2
MIRT667748 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT668088 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT668119 GK5 glycerol kinase 5 (putative) 2 2
MIRT668166 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668346 STXBP2 syntaxin binding protein 2 2 2
MIRT668509 ESYT2 extended synaptotagmin 2 2 2
MIRT669291 C17orf85 nuclear cap binding subunit 3 2 2
MIRT669547 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT669778 CNDP1 carnosine dipeptidase 1 2 2
MIRT669858 BROX BRO1 domain and CAAX motif containing 2 4
MIRT670017 TECPR1 tectonin beta-propeller repeat containing 1 2 2
MIRT670177 CCDC142 coiled-coil domain containing 142 2 2
MIRT671107 ZNF841 zinc finger protein 841 2 2
MIRT671351 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 2
MIRT671476 FLYWCH2 FLYWCH family member 2 2 2
MIRT671492 SLC38A9 solute carrier family 38 member 9 2 2
MIRT671554 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT671925 PLEKHS1 pleckstrin homology domain containing S1 2 4
MIRT672196 F2 coagulation factor II, thrombin 2 2
MIRT672217 DCAF7 DDB1 and CUL4 associated factor 7 2 2
MIRT672252 SIK2 salt inducible kinase 2 2 2
MIRT672290 GP2 glycoprotein 2 2 2
MIRT672430 POLR2D RNA polymerase II subunit D 2 2
MIRT672597 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT672901 KRBA2 KRAB-A domain containing 2 2 2
MIRT672958 ZNF655 zinc finger protein 655 2 2
MIRT673096 SYNPO2L synaptopodin 2 like 2 2
MIRT673171 TMEM56 transmembrane protein 56 2 2
MIRT673251 INO80 INO80 complex subunit 2 2
MIRT673296 RNF19B ring finger protein 19B 2 2
MIRT673574 KDELC2 KDEL motif containing 2 2 2
MIRT673586 KIF1C kinesin family member 1C 2 2
MIRT673737 TCF23 transcription factor 23 2 2
MIRT673767 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674215 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT674283 NAGK N-acetylglucosamine kinase 2 2
MIRT674338 KCMF1 potassium channel modulatory factor 1 2 2
MIRT674517 PRR23A proline rich 23A 2 2
MIRT675100 SNTB2 syntrophin beta 2 2 2
MIRT675144 MOGAT1 monoacylglycerol O-acyltransferase 1 2 4
MIRT675223 CLK4 CDC like kinase 4 2 2
MIRT675263 ZNF431 zinc finger protein 431 2 2
MIRT675577 WWC1 WW and C2 domain containing 1 2 2
MIRT676025 C9orf69 transmembrane protein 250 2 2
MIRT676430 PLEKHM3 pleckstrin homology domain containing M3 2 2
MIRT676560 VSIG1 V-set and immunoglobulin domain containing 1 2 2
MIRT676596 ARIH2OS ariadne RBR E3 ubiquitin protein ligase 2 opposite strand 2 2
MIRT678576 TMEM168 transmembrane protein 168 2 2
MIRT678756 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT680344 ZNF281 zinc finger protein 281 2 2
MIRT680467 C3 complement C3 2 2
MIRT682826 FLG2 filaggrin family member 2 2 2
MIRT682881 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT684404 TMEM180 major facilitator superfamily domain containing 13A 2 2
MIRT685275 KIAA1143 KIAA1143 2 2
MIRT686061 KCNA7 potassium voltage-gated channel subfamily A member 7 2 2
MIRT687526 NASP nuclear autoantigenic sperm protein 2 2
MIRT691760 BCL2L15 BCL2 like 15 2 2
MIRT693890 C3orf62 chromosome 3 open reading frame 62 2 2
MIRT699342 SLC35E1 solute carrier family 35 member E1 2 2
MIRT699909 RUNDC1 RUN domain containing 1 2 2
MIRT700536 PTPDC1 protein tyrosine phosphatase domain containing 1 2 2
MIRT701807 MRPS25 mitochondrial ribosomal protein S25 2 2
MIRT702174 LYRM4 LYR motif containing 4 2 2
MIRT706205 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT706659 RNF216 ring finger protein 216 2 2
MIRT706682 COL13A1 collagen type XIII alpha 1 chain 2 2
MIRT706705 GPR155 G protein-coupled receptor 155 2 2
MIRT706777 ANKRD36 ankyrin repeat domain 36 2 2
MIRT706844 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706863 MAFF MAF bZIP transcription factor F 2 2
MIRT706896 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT706916 THAP6 THAP domain containing 6 2 2
MIRT706962 FANCC Fanconi anemia complementation group C 2 2
MIRT706980 XPO5 exportin 5 2 2
MIRT707015 RRP36 ribosomal RNA processing 36 2 2
MIRT707032 ACTR5 ARP5 actin related protein 5 homolog 2 2
MIRT707072 MED29 mediator complex subunit 29 2 2
MIRT709368 SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 2 2
MIRT720092 SPTLC3 serine palmitoyltransferase long chain base subunit 3 2 2
MIRT721330 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT724198 MED7 mediator complex subunit 7 2 2
MIRT725403 KIF6 kinesin family member 6 2 2
MIRT733035 COL4A2 collagen type IV alpha 2 chain 1 0
MIRT733036 COL26A1 collagen type XXVI alpha 1 chain 1 0
MIRT733426 PLK1 polo like kinase 1 3 0
MIRT734484 PLD1 phospholipase D1 3 0
MIRT736044 CBL Cbl proto-oncogene 3 0
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