miRTarBase - #MIRT000328


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pre-miRNA Information
pre-miRNA hsa-mir-133a-1   
Genomic Coordinates chr18: 21825698 - 21825785
Synonyms MIRN133A1, MIR133A1
Description Homo sapiens miR-133a-1 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-133a-2   
Genomic Coordinates chr20: 62564912 - 62565013
Synonyms MIRN133A2, MIR133A2
Description Homo sapiens miR-133a-2 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-133a-3p
Sequence 53| UUUGGUCCCCUUCAACCAGCUG |74
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30104664 8 COSMIC
COSN30455205 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369575411 9 dbSNP
rs746815210 11 dbSNP
rs1382873526 13 dbSNP
rs553267926 15 dbSNP
rs1172821195 16 dbSNP
rs182673735 19 dbSNP
rs781929120 20 dbSNP
rs1296628341 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma .
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Muscle Reverse transcription-polymerase chain reaction
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma Real-time reverse transcription PCR
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Serum Real-time polymerase chain reaction
Gene Information
Gene Symbol ERG   
Synonyms erg-3, p55
Description ERG, ETS transcription factor
Transcript NM_001136154   
Other Transcripts NM_001136155 , NM_004449 , NM_182918   
Expression
Putative miRNA Targets on ERG
3'UTR of ERG
(miRNA target sites are highlighted)		 
>ERG|NM_001136154|3'UTR
   1 AGACCTGGCGGAGGCTTTTCCCATCAGCGTGCATTCACCAGCCCATCGCCACAAACTCTATCGGAGAACATGAATCAAAA
  81 GTGCCTCAAGAGGAATGAAAAAAGCTTTACTGGGGCTGGGGAAGGAAGCCGGGGAAGAGATCCAAAGACTCTTGGGAGGG
 161 AGTTACTGAAGTCTTACTACAGAAATGAGGAGGATGCTAAAAATGTCACGAATATGGACATATCATCTGTGGACTGACCT
 241 TGTAAAAGACAGTGTATGTAGAAGCATGAAGTCTTAAGGACAAAGTGCCAAAGAAAGTGGTCTTAAGAAATGTATAAACT
 321 TTAGAGTAGAGTTTGGAATCCCACTAATGCAAACTGGGATGAAACTAAAGCAATAGAAACAACACAGTTTTGACCTAACA
 401 TACCGTTTATAATGCCATTTTAAGGAAAACTACCTGTATTTAAAAATAGAAACATATCAAAAACAAGAGAAAAGACACGA
 481 GAGAGACTGTGGCCCATCAACAGACGTTGATATGCAACTGCATGGCATGTGCTGTTTTGGTTGAAATCAAATACATTCCG
 561 TTTGATGGACAGCTGTCAGCTTTCTCAAACTGTGAAGATGACCCAAAGTTTCCAACTCCTTTACAGTATTACCGGGACTA
 641 TGAACTAAAAGGTGGGACTGAGGATGTGTATAGAGTGAGCGTGTGATTGTAGACAGAGGGGTGAAGAAGGAGGAGGAAGA
 721 GGCAGAGAAGGAGGAGACCAGGGCTGGGAAAGAAACTTCTCAAGCAATGAAGACTGGACTCAGGACATTTGGGGACTGTG
 801 TACAATGAGTTATGGAGACTCGAGGGTTCATGCAGTCAGTGTTATACCAAACCCAGTGTTAGGAGAAAGGACACAGCGTA
 881 ATGGAGAAAGGGGAAGTAGTAGAATTCAGAAACAAAAATGCGCATCTCTTTCTTTGTTTGTCAAATGAAAATTTTAACTG
 961 GAATTGTCTGATATTTAAGAGAAACATTCAGGACCTCATCATTATGTGGGGGCTTTGTTCTCCACAGGGTCAGGTAAGAG
1041 ATGGCCTTCTTGGCTGCCACAATCAGAAATCACGCAGGCATTTTGGGTAGGCGGCCTCCAGTTTTCCTTTGAGTCGCGAA
1121 CGCTGTGCGTTTGTCAGAATGAAGTATACAAGTCAATGTTTTTCCCCCTTTTTATATAATAATTATATAACTTATGCATT
1201 TATACACTACGAGTTGATCTCGGCCAGCCAAAGACACACGACAAAAGAGACAATCGATATAATGTGGCCTTGAATTTTAA
1281 CTCTGTATGCTTAATGTTTACAATATGAAGTTATTAGTTCTTAGAATGCAGAATGTATGTAATAAAATAAGCTTGGCCTA
1361 GCATGGCAAATCAGATTTATACAGGAGTCTGCATTTGCACTTTTTTTAGTGACTAAAGTTGCTTAATGAAAACATGTGCT
1441 GAATGTTGTGGATTTTGTGTTATAATTTACTTTGTCCAGGAACTTGTGCAAGGGAGAGCCAAGGAAATAGGATGTTTGGC
1521 ACCCAAATGGCGTCAGCCTCTCCAGGTCCTTCTTGCCTCCCCTCCTGTCTTTTATTTCTAGCCCCTTTTGGAACAGAAGG
1601 ACCCCGGGTTTCACATTGGAGCCTCCATATTTATGCCTGGAATGGAAAGAGGCCTATGAAGCTGGGGTTGTCATTGAGAA
1681 ATTCTAGTTCAGCACCTGGTCACAAATCACCCTTAATTCCTGCTATGATTAAAATACATTTGTTGAACAGTGAACAAGCT
1761 ACCACTCGTAAGGCAAACTGTATTATTACTGGCAAATAAAGCGTCATGGATAGCTGCAATTTCTCACTTTACAGAAACAA
1841 GGGATAACGTCTAGATTTGCTGCGGGGTTTCTCTTTCAGGAGCTCTCACTAGGTAGACAGCTTTAGTCCTGCTACATCAG
1921 AGTTACCTGGGCACTGTGGCTTGGGATTCACTAGCCCTGAGCCTGATGTTGCTGGCTATCCCTTGAAGACAATGTTTATT
2001 TCCATAATCTAGAGTCAGTTTCCCTGGGCATCTTTTCTTTGAATCACAAATGCTGCCAACCTTGGTCCAGGTGAAGGCAA
2081 CTCAAAAGGTGAAAATACAAGGTGACCGTGCGAAGGCGCTAGCCGAAACATCTTAGCTGAATAGGTTTCTGAACTGGCCC
2161 TTTTCATAGCTGTTTCAGGGCCTGTTTTTTTCACGTTGCAGTCCTTTTGCTATGATTATGTGAAGTTGCCAAACCTCTGT
2241 GCTGTGGATGTTTTGGCAGTGGGCTTTGAAGTCGGCAGGACACGATTACCAATGCTCCTGACACCCCGTGTCATTTGGAT
2321 TAGACGGAGCCCAACCATCCATCATTTTGCAGCAGCCTGGGAAGGCCCACAAAGTGCCCGTATCTCCTTAGGGAAAATAA
2401 ATAAATACAATCATGAAAGCTGGCAGTTAGGCTGACCCAAACTGTGCTAATGGAAAAGATCAGTCATTTTTATTTTGGAA
2481 TGCAAAGTCAAGACACACCTACATTCTTCATAGAAATACACATTTACTTGGATAATCACTCAGTTCTCTCTTCAAGACTG
2561 TCTCATGAGCAAGATCATAAAAACAAGACATGATTATCATATTCAATTTTAACAGATGTTTTCCATTAGATCCCTCAACC
2641 CTCCACCCCCAGTCCAGGTTATTAGCAAGTCTTATGAGCAACTGGGATAATTTTGGATAACATGATAATACTGAGTTCCT
2721 TCAAATACATAATTCTTAAATTGTTTCAAAATGGCATTAACTCTCTGTTACTGTTGTAATCTAATTCCAAAGCCCCCTCC
2801 AGGTCATATTCATAATTGCATGAACCTTTTCTCTCTGTTTGTCCCTGTCTCTTGGCTTGCCCTGATGTATACTCAGACTC
2881 CTGTACAATCTTACTCCTGCTGGCAAGAGATTTGTCTTCTTTTCTTGTCTTCAATTGGCTTTCGGGCCTTGTATGTGGTA
2961 AAATCACCAAATCACAGTCAAGACTGTGTTTTTGTTCCTAGTTTGATGCCCTTATGTCCCGGAGGGGTTCACAAAGTGCT
3041 TTGTCAGGACTGCTGCAGTTAGAAGGCTCACTGCTTCTCCTAAGCCTTCTGCACAGATGTGGCACCTGCAACCCAGGAGC
3121 AGGAGCCGGAGGAGCTGCCCTCTGACAGCAGGTGCAGCAGAGATGGCTACAGCTCAGGAGCTGGGAAGGTGATGGGGCAC
3201 AGGGAAAGCACAGATGTTCTGCAGCGCCCCAAAGTGACCCATTGCCTGGAGAAAGAGAAGAAAATATTTTTTAAAAAGCT
3281 AGTTTATTTAGCTTCTCATTAATTCATTCAAATAAAGTCGTGAGGTGACTAATTAGAGAATAAAAATTACTTTGGACTAC
3361 TCAAAAATACACCAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gucgaccaacUUC--CCCUGGUUu 5'
                    |||  |||||::| 
Target 5' tatgaactaaAAGGTGGGACTGAg 3'
 639 - 662 118.00 -11.30
2 
miRNA  3' guCGAC-CAACUUCCCCUGGUUu 5'
            || | |  |:||| |||||: 
Target 5' agGCAGAGAAGGAGGAGACCAGg 3'
 720 - 742 116.00 -18.20
3 
miRNA  3' gucGACCAACUUCCCCU--GGUUu 5'
             :||| | |:  |||  |||| 
Target 5' catTTGGATTAGACGGAGCCCAAc 3'
 2312 - 2335 115.00 -8.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31503061 1 COSMIC
COSN30503226 7 COSMIC
COSN30504214 9 COSMIC
COSN19736534 10 COSMIC
COSN31507076 18 COSMIC
COSN30553001 21 COSMIC
COSN30530214 27 COSMIC
COSN30501121 28 COSMIC
COSN13883510 48 COSMIC
COSN30511846 114 COSMIC
COSN23571462 154 COSMIC
COSN22398296 187 COSMIC
COSN31528211 210 COSMIC
COSN23172566 279 COSMIC
COSN29975927 395 COSMIC
COSN31596542 466 COSMIC
COSN30173513 572 COSMIC
COSN31537732 638 COSMIC
COSN30177189 781 COSMIC
COSN31569393 877 COSMIC
COSN31534958 902 COSMIC
COSN31552626 921 COSMIC
COSN31568110 997 COSMIC
COSN10026501 1049 COSMIC
COSN31542623 1050 COSMIC
COSN26226515 1053 COSMIC
COSN1892455 1117 COSMIC
COSN24618725 1121 COSMIC
COSN7145886 1129 COSMIC
COSN19662887 1221 COSMIC
COSN31487952 1256 COSMIC
COSN29633864 1348 COSMIC
COSN1256553 1655 COSMIC
COSN4783749 1661 COSMIC
COSN19029888 1768 COSMIC
COSN17919876 1849 COSMIC
COSN24294851 2159 COSMIC
COSN16233586 2233 COSMIC
COSN28201635 2234 COSMIC
COSN32170145 2268 COSMIC
COSN18989861 2326 COSMIC
COSN20116915 2599 COSMIC
COSN8007601 2703 COSMIC
COSN9158473 2880 COSMIC
COSN9158472 3029 COSMIC
COSN10026500 3089 COSMIC
COSN26405350 3286 COSMIC
COSN21230659 3362 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs749392709 2 dbSNP
rs1016127039 5 dbSNP
rs185211409 8 dbSNP
rs367594212 9 dbSNP
rs886367077 10 dbSNP
rs1490733158 13 dbSNP
rs748434547 15 dbSNP
rs1383985202 20 dbSNP
rs541024016 28 dbSNP
rs201302744 29 dbSNP
rs769946588 33 dbSNP
rs747446443 37 dbSNP
rs1224294874 39 dbSNP
rs780550317 42 dbSNP
rs756742175 43 dbSNP
rs753450790 47 dbSNP
rs777258815 48 dbSNP
rs1356157213 55 dbSNP
rs565436535 62 dbSNP
rs1408445805 63 dbSNP
rs899761503 69 dbSNP
rs202050025 70 dbSNP
rs1336575733 71 dbSNP
rs1398346424 72 dbSNP
rs1387473610 83 dbSNP
rs545712273 84 dbSNP
rs1384959145 99 dbSNP
rs747877303 105 dbSNP
rs1170967966 107 dbSNP
rs1018333446 108 dbSNP
rs748396919 109 dbSNP
rs180793374 110 dbSNP
rs900236109 112 dbSNP
rs1038832689 115 dbSNP
rs947531886 119 dbSNP
rs1441471022 126 dbSNP
rs867303639 130 dbSNP
rs371652920 131 dbSNP
rs1367104230 132 dbSNP
rs934872510 134 dbSNP
rs556761244 136 dbSNP
rs1447007503 139 dbSNP
rs1184689368 144 dbSNP
rs1372584888 153 dbSNP
rs536860175 176 dbSNP
rs781187528 179 dbSNP
rs1046802222 187 dbSNP
rs1169711013 190 dbSNP
rs1397548480 195 dbSNP
rs371955859 204 dbSNP
rs768868549 209 dbSNP
rs981823822 212 dbSNP
rs1037850028 215 dbSNP
rs1294681947 217 dbSNP
rs1192364836 218 dbSNP
rs771540005 219 dbSNP
rs747016871 220 dbSNP
rs1322444901 225 dbSNP
rs80150100 226 dbSNP
rs1261685089 228 dbSNP
rs1205357390 235 dbSNP
rs141858676 238 dbSNP
rs533547854 253 dbSNP
rs1261710835 256 dbSNP
rs1271101147 259 dbSNP
rs963178670 262 dbSNP
rs1195473757 281 dbSNP
rs1373680157 282 dbSNP
rs1215477945 288 dbSNP
rs1480247515 292 dbSNP
rs1335431382 300 dbSNP
rs1431161940 303 dbSNP
rs571270770 307 dbSNP
rs1016017437 309 dbSNP
rs1004732053 312 dbSNP
rs1470182652 322 dbSNP
rs1288053052 323 dbSNP
rs949406136 324 dbSNP
rs867213976 326 dbSNP
rs917950416 333 dbSNP
rs538199643 336 dbSNP
rs886333548 341 dbSNP
rs1221310113 352 dbSNP
rs1284881006 359 dbSNP
rs988184641 366 dbSNP
rs1030273050 373 dbSNP
rs1260476107 386 dbSNP
rs1386484312 401 dbSNP
rs997580384 405 dbSNP
rs1485198920 409 dbSNP
rs1032148987 447 dbSNP
rs900204986 449 dbSNP
rs1038801632 456 dbSNP
rs1490186982 456 dbSNP
rs1197353235 458 dbSNP
rs964243388 458 dbSNP
rs947083658 465 dbSNP
rs1158155612 467 dbSNP
rs1361806607 474 dbSNP
rs892896943 478 dbSNP
rs551368046 479 dbSNP
rs1364884666 485 dbSNP
rs1053665527 488 dbSNP
rs1018176475 505 dbSNP
rs934862067 506 dbSNP
rs1345798705 509 dbSNP
rs1169205037 512 dbSNP
rs750226487 513 dbSNP
rs890792269 519 dbSNP
rs73437666 530 dbSNP
rs1359326297 536 dbSNP
rs948714059 537 dbSNP
rs1374306402 541 dbSNP
rs1294001522 556 dbSNP
rs915951663 559 dbSNP
rs190394016 560 dbSNP
rs1248165034 564 dbSNP
rs374618860 565 dbSNP
rs1420724500 575 dbSNP
rs570981577 588 dbSNP
rs962740457 597 dbSNP
rs1384585519 602 dbSNP
rs908643473 609 dbSNP
rs1164969894 613 dbSNP
rs898270526 623 dbSNP
rs1461186983 624 dbSNP
rs983672157 633 dbSNP
rs1375060853 634 dbSNP
rs185656190 635 dbSNP
rs1310418109 637 dbSNP
rs1194020924 649 dbSNP
rs1382745996 653 dbSNP
rs1030657302 657 dbSNP
rs774331718 671 dbSNP
rs367552184 680 dbSNP
rs905394701 681 dbSNP
rs1252037335 684 dbSNP
rs796903641 699 dbSNP
rs1204096570 703 dbSNP
rs148580535 707 dbSNP
rs768762227 710 dbSNP
rs1199082678 715 dbSNP
rs1052448132 718 dbSNP
rs964628922 721 dbSNP
rs1185288155 728 dbSNP
rs1017244528 737 dbSNP
rs753546646 738 dbSNP
rs925338825 739 dbSNP
rs1427474565 742 dbSNP
rs892865611 764 dbSNP
rs1355962831 766 dbSNP
rs979539223 779 dbSNP
rs1332499418 787 dbSNP
rs1052895059 800 dbSNP
rs1405747177 811 dbSNP
rs147542406 814 dbSNP
rs907401401 815 dbSNP
rs1380515837 821 dbSNP
rs1214113789 822 dbSNP
rs1293484302 826 dbSNP
rs1309517454 827 dbSNP
rs1219431249 830 dbSNP
rs1376632333 834 dbSNP
rs1262298566 835 dbSNP
rs1327369750 838 dbSNP
rs1205330118 843 dbSNP
rs547917191 849 dbSNP
rs1485488910 851 dbSNP
rs1184294834 858 dbSNP
rs1420974242 874 dbSNP
rs181891829 877 dbSNP
rs565315730 878 dbSNP
rs1412186162 884 dbSNP
rs749058703 890 dbSNP
rs1398002921 891 dbSNP
rs1429032938 894 dbSNP
rs1468630508 894 dbSNP
rs1336533874 896 dbSNP
rs1360291148 897 dbSNP
rs1430595937 907 dbSNP
rs545433914 919 dbSNP
rs955487799 921 dbSNP
rs993777966 922 dbSNP
rs1321661114 924 dbSNP
rs570060947 936 dbSNP
rs754539524 936 dbSNP
rs1001731411 942 dbSNP
rs941389658 966 dbSNP
rs1213497084 967 dbSNP
rs908608391 973 dbSNP
rs1195143202 984 dbSNP
rs1243357605 986 dbSNP
rs760212225 990 dbSNP
rs1454509493 994 dbSNP
rs190047585 1009 dbSNP
rs1198060029 1013 dbSNP
rs1045647845 1017 dbSNP
rs1179573764 1017 dbSNP
rs1439537605 1027 dbSNP
rs950605916 1032 dbSNP
rs923092449 1044 dbSNP
rs1426254532 1050 dbSNP
rs1400655081 1059 dbSNP
rs975923568 1060 dbSNP
rs1363006786 1061 dbSNP
rs1013808663 1064 dbSNP
rs543204435 1073 dbSNP
rs964591566 1074 dbSNP
rs1438823451 1077 dbSNP
rs1275241339 1078 dbSNP
rs1052710049 1080 dbSNP
rs1222008513 1083 dbSNP
rs374411054 1085 dbSNP
rs1017548769 1092 dbSNP
rs574219213 1093 dbSNP
rs766423761 1096 dbSNP
rs925306304 1096 dbSNP
rs1043829714 1104 dbSNP
rs1490745378 1107 dbSNP
rs185584298 1115 dbSNP
rs1247664310 1116 dbSNP
rs942779870 1117 dbSNP
rs1175840400 1118 dbSNP
rs533919369 1121 dbSNP
rs1353419230 1122 dbSNP
rs577677230 1128 dbSNP
rs182244764 1129 dbSNP
rs1407306972 1134 dbSNP
rs1324368690 1135 dbSNP
rs1354155463 1145 dbSNP
rs1278214004 1147 dbSNP
rs1311141865 1148 dbSNP
rs537448464 1155 dbSNP
rs918492474 1156 dbSNP
rs906949619 1163 dbSNP
rs972660511 1164 dbSNP
rs1209910260 1173 dbSNP
rs962351840 1174 dbSNP
rs766918021 1175 dbSNP
rs1240366924 1177 dbSNP
rs1001257570 1179 dbSNP
rs1183453662 1181 dbSNP
rs970225997 1185 dbSNP
rs1473854201 1187 dbSNP
rs1023780798 1189 dbSNP
rs1163897033 1195 dbSNP
rs1045864329 1210 dbSNP
rs188236598 1211 dbSNP
rs894712921 1214 dbSNP
rs1333146715 1221 dbSNP
rs896683184 1222 dbSNP
rs1038619606 1223 dbSNP
rs1451832717 1233 dbSNP
rs941358636 1236 dbSNP
rs1342183985 1238 dbSNP
rs143177109 1239 dbSNP
rs139255836 1240 dbSNP
rs566687986 1242 dbSNP
rs1047510354 1255 dbSNP
rs763482025 1256 dbSNP
rs1260408633 1266 dbSNP
rs922689215 1275 dbSNP
rs1203426108 1287 dbSNP
rs547558320 1303 dbSNP
rs1241893679 1309 dbSNP
rs1444612483 1314 dbSNP
rs1484697914 1320 dbSNP
rs1188371466 1325 dbSNP
rs975887639 1334 dbSNP
rs1372527295 1335 dbSNP
rs1173010122 1351 dbSNP
rs1474558412 1351 dbSNP
rs796125187 1356 dbSNP
rs910457624 1368 dbSNP
rs534022480 1374 dbSNP
rs1211858431 1375 dbSNP
rs1404321861 1382 dbSNP
rs1488107189 1385 dbSNP
rs773512930 1391 dbSNP
rs933820174 1399 dbSNP
rs1278516614 1407 dbSNP
rs1322383055 1408 dbSNP
rs990099782 1414 dbSNP
rs957258014 1419 dbSNP
rs1254598354 1420 dbSNP
rs770180818 1421 dbSNP
rs1347778998 1422 dbSNP
rs527752427 1428 dbSNP
rs1351888006 1436 dbSNP
rs1284051024 1444 dbSNP
rs977498753 1445 dbSNP
rs73437665 1446 dbSNP
rs35187357 1458 dbSNP
rs1024031891 1459 dbSNP
rs909524238 1462 dbSNP
rs145269203 1469 dbSNP
rs569791112 1469 dbSNP
rs1314218664 1481 dbSNP
rs1379099253 1484 dbSNP
rs1466498115 1494 dbSNP
rs1013026284 1502 dbSNP
rs1344193033 1503 dbSNP
rs1315826396 1513 dbSNP
rs1344518454 1514 dbSNP
rs1402164128 1519 dbSNP
rs894681948 1523 dbSNP
rs1017139742 1524 dbSNP
rs1005765040 1529 dbSNP
rs887367975 1531 dbSNP
rs183723337 1532 dbSNP
rs1483325630 1537 dbSNP
rs934001777 1538 dbSNP
rs1299662668 1540 dbSNP
rs1333124309 1544 dbSNP
rs557911294 1546 dbSNP
rs969772762 1549 dbSNP
rs1474221845 1550 dbSNP
rs1024460491 1551 dbSNP
rs1218945740 1561 dbSNP
rs901237427 1562 dbSNP
rs1188804890 1563 dbSNP
rs1490253081 1583 dbSNP
rs1475138754 1585 dbSNP
rs1240533955 1591 dbSNP
rs1218216606 1594 dbSNP
rs1189631364 1595 dbSNP
rs1269203494 1603 dbSNP
rs1039837332 1604 dbSNP
rs551755084 1605 dbSNP
rs531748305 1606 dbSNP
rs563168788 1613 dbSNP
rs999742120 1614 dbSNP
rs1441432454 1615 dbSNP
rs904116495 1616 dbSNP
rs1294469935 1621 dbSNP
rs1422367225 1623 dbSNP
rs776995645 1628 dbSNP
rs1233325186 1630 dbSNP
rs1022571584 1633 dbSNP
rs1007292478 1635 dbSNP
rs1375374418 1643 dbSNP
rs768958493 1643 dbSNP
rs924536753 1649 dbSNP
rs1358732325 1652 dbSNP
rs565895562 1656 dbSNP
rs1267514658 1665 dbSNP
rs1488916269 1669 dbSNP
rs1325016720 1673 dbSNP
rs977096673 1674 dbSNP
rs934080767 1687 dbSNP
rs1441481817 1692 dbSNP
rs1179105323 1694 dbSNP
rs971500536 1700 dbSNP
rs1421607840 1707 dbSNP
rs1166269389 1727 dbSNP
rs1024002141 1739 dbSNP
rs991239083 1744 dbSNP
rs1165601609 1760 dbSNP
rs1297991879 1762 dbSNP
rs866731751 1763 dbSNP
rs958452483 1767 dbSNP
rs1017025668 1768 dbSNP
rs1332704227 1780 dbSNP
rs1382674715 1785 dbSNP
rs1226728401 1789 dbSNP
rs1417475008 1789 dbSNP
rs941258703 1791 dbSNP
rs1475888716 1802 dbSNP
rs543391826 1803 dbSNP
rs980071369 1806 dbSNP
rs1255924274 1807 dbSNP
rs948381426 1809 dbSNP
rs1199025472 1810 dbSNP
rs951636576 1818 dbSNP
rs529447439 1819 dbSNP
rs1192090395 1831 dbSNP
rs1256187214 1838 dbSNP
rs200647002 1848 dbSNP
rs560698493 1849 dbSNP
rs1425316916 1854 dbSNP
rs998182756 1857 dbSNP
rs1306403598 1861 dbSNP
rs1359134615 1862 dbSNP
rs901207317 1863 dbSNP
rs1304683395 1864 dbSNP
rs1215927002 1866 dbSNP
rs1039806251 1874 dbSNP
rs1031144602 1878 dbSNP
rs1381717775 1881 dbSNP
rs978239706 1894 dbSNP
rs1320246895 1901 dbSNP
rs1345097018 1909 dbSNP
rs968239490 1910 dbSNP
rs1310393882 1916 dbSNP
rs1362280178 1918 dbSNP
rs758476406 1923 dbSNP
rs1256074421 1926 dbSNP
rs1485299860 1932 dbSNP
rs1006939658 1943 dbSNP
rs1302259313 1949 dbSNP
rs2836354 1950 dbSNP
rs78091230 1953 dbSNP
rs1029673078 1967 dbSNP
rs998195724 1978 dbSNP
rs2836353 1979 dbSNP
rs924539562 1983 dbSNP
rs1419226986 1987 dbSNP
rs1005328909 1989 dbSNP
rs561609523 1999 dbSNP
rs1352809722 2009 dbSNP
rs888319335 2010 dbSNP
rs543795187 2012 dbSNP
rs879184700 2016 dbSNP
rs745805213 2019 dbSNP
rs1279320899 2025 dbSNP
rs991121218 2031 dbSNP
rs191218826 2038 dbSNP
rs114539388 2043 dbSNP
rs1287491540 2062 dbSNP
rs1488426470 2065 dbSNP
rs1221202868 2068 dbSNP
rs1244618249 2069 dbSNP
rs535775280 2077 dbSNP
rs1193263067 2078 dbSNP
rs951662866 2082 dbSNP
rs1025889099 2083 dbSNP
rs1439577193 2085 dbSNP
rs1156951182 2099 dbSNP
rs998883973 2107 dbSNP
rs370921292 2108 dbSNP
rs1254087126 2111 dbSNP
rs146945716 2112 dbSNP
rs1006910046 2117 dbSNP
rs118017111 2118 dbSNP
rs1054308633 2124 dbSNP
rs187184098 2125 dbSNP
rs115263398 2143 dbSNP
rs1287358890 2151 dbSNP
rs1452942513 2154 dbSNP
rs551947724 2160 dbSNP
rs1457719389 2177 dbSNP
rs1177239256 2180 dbSNP
rs550213674 2184 dbSNP
rs1382691994 2187 dbSNP
rs998123965 2192 dbSNP
rs866757132 2194 dbSNP
rs117007020 2195 dbSNP
rs569305090 2196 dbSNP
rs1407256533 2202 dbSNP
rs1055362072 2209 dbSNP
rs1399205487 2212 dbSNP
rs1349764478 2213 dbSNP
rs1444482130 2219 dbSNP
rs1333351211 2220 dbSNP
rs1377523604 2223 dbSNP
rs1243482794 2229 dbSNP
rs1303934302 2229 dbSNP
rs1281881788 2233 dbSNP
rs1358052286 2235 dbSNP
rs1390729064 2242 dbSNP
rs1228476831 2244 dbSNP
rs1274198955 2247 dbSNP
rs1317761652 2250 dbSNP
rs752241339 2254 dbSNP
rs937034229 2256 dbSNP
rs1015624232 2258 dbSNP
rs145629856 2271 dbSNP
rs549410533 2273 dbSNP
rs1374944973 2274 dbSNP
rs984313424 2277 dbSNP
rs370828224 2281 dbSNP
rs1436892837 2284 dbSNP
rs1013218874 2291 dbSNP
rs1423176433 2297 dbSNP
rs1463913834 2302 dbSNP
rs1172511699 2305 dbSNP
rs1400978394 2306 dbSNP
rs529561296 2307 dbSNP
rs62217880 2308 dbSNP
rs1448111209 2315 dbSNP
rs1413101622 2323 dbSNP
rs763427321 2325 dbSNP
rs965591705 2326 dbSNP
rs1018556167 2329 dbSNP
rs376067638 2334 dbSNP
rs1483063628 2341 dbSNP
rs1200328287 2362 dbSNP
rs1276596811 2363 dbSNP
rs958059131 2370 dbSNP
rs1208271109 2379 dbSNP
rs540778201 2380 dbSNP
rs1042789836 2386 dbSNP
rs1195603266 2408 dbSNP
rs1423995998 2419 dbSNP
rs1032423765 2422 dbSNP
rs149268075 2423 dbSNP
rs1170813761 2449 dbSNP
rs902603055 2451 dbSNP
rs915367136 2454 dbSNP
rs1297011865 2462 dbSNP
rs1020506536 2468 dbSNP
rs1314917809 2487 dbSNP
rs183812994 2492 dbSNP
rs1014058467 2506 dbSNP
rs762424981 2511 dbSNP
rs895716262 2517 dbSNP
rs1308993048 2521 dbSNP
rs1327325309 2522 dbSNP
rs1232980813 2523 dbSNP
rs1055669834 2539 dbSNP
rs1224330985 2542 dbSNP
rs985665342 2543 dbSNP
rs954380913 2546 dbSNP
rs922843831 2547 dbSNP
rs1354899539 2553 dbSNP
rs937002909 2554 dbSNP
rs888150536 2561 dbSNP
rs1048063024 2564 dbSNP
rs543929960 2568 dbSNP
rs1432437888 2569 dbSNP
rs574878462 2575 dbSNP
rs1379344904 2577 dbSNP
rs201400222 2599 dbSNP
rs918357120 2600 dbSNP
rs111346388 2603 dbSNP
rs10546014 2604 dbSNP
rs780507595 2604 dbSNP
rs370491052 2605 dbSNP
rs1376236347 2623 dbSNP
rs765594903 2631 dbSNP
rs1358012674 2633 dbSNP
rs952838895 2635 dbSNP
rs1455666549 2639 dbSNP
rs1023194405 2640 dbSNP
rs1288539895 2650 dbSNP
rs6517463 2652 dbSNP
rs1321942607 2669 dbSNP
rs895675322 2673 dbSNP
rs780567701 2676 dbSNP
rs1160450255 2683 dbSNP
rs944211190 2695 dbSNP
rs1475205034 2701 dbSNP
rs1416498196 2702 dbSNP
rs1351682284 2707 dbSNP
rs1242385112 2718 dbSNP
rs911469144 2726 dbSNP
rs1185098644 2729 dbSNP
rs1475920479 2731 dbSNP
rs560781746 2754 dbSNP
rs1204202679 2758 dbSNP
rs1269146325 2766 dbSNP
rs1378402509 2767 dbSNP
rs998775778 2767 dbSNP
rs17815631 2769 dbSNP
rs1262343177 2779 dbSNP
rs1032721965 2788 dbSNP
rs1209245764 2797 dbSNP
rs1334124782 2800 dbSNP
rs1367562975 2804 dbSNP
rs1042759259 2807 dbSNP
rs947102894 2809 dbSNP
rs888853641 2811 dbSNP
rs769042164 2816 dbSNP
rs1442089857 2830 dbSNP
rs1331325526 2837 dbSNP
rs373076901 2837 dbSNP
rs764169459 2843 dbSNP
rs138544898 2844 dbSNP
rs1307748928 2847 dbSNP
rs1321377922 2854 dbSNP
rs922812863 2874 dbSNP
rs150081573 2882 dbSNP
rs775771578 2886 dbSNP
rs1364516380 2888 dbSNP
rs1289858981 2894 dbSNP
rs1461271820 2895 dbSNP
rs940284843 2896 dbSNP
rs1254793541 2899 dbSNP
rs769437154 2900 dbSNP
rs1166553700 2907 dbSNP
rs1167743244 2920 dbSNP
rs895689183 2923 dbSNP
rs140728206 2934 dbSNP
rs1001369322 2937 dbSNP
rs55950649 2942 dbSNP
rs992024747 2943 dbSNP
rs1048507161 2944 dbSNP
rs1378445961 2955 dbSNP
rs538379315 2956 dbSNP
rs1394361580 2963 dbSNP
rs896878995 2977 dbSNP
rs74504273 2983 dbSNP
rs745873816 2992 dbSNP
rs1319929608 2994 dbSNP
rs541550020 2998 dbSNP
rs1255335732 3009 dbSNP
rs1021576749 3013 dbSNP
rs1183071315 3015 dbSNP
rs1011229055 3016 dbSNP
rs1477266165 3018 dbSNP
rs911353158 3020 dbSNP
rs549348482 3021 dbSNP
rs1412137868 3025 dbSNP
rs1171817935 3028 dbSNP
rs774380472 3030 dbSNP
rs1464653548 3043 dbSNP
rs1225475116 3052 dbSNP
rs1376326341 3058 dbSNP
rs529278362 3066 dbSNP
rs1399571183 3071 dbSNP
rs1328372364 3075 dbSNP
rs888813085 3081 dbSNP
rs1050180283 3092 dbSNP
rs933066462 3094 dbSNP
rs1440542333 3097 dbSNP
rs770727998 3102 dbSNP
rs925574165 3107 dbSNP
rs978477989 3117 dbSNP
rs966761303 3126 dbSNP
rs749127945 3127 dbSNP
rs369834291 3128 dbSNP
rs1166863560 3137 dbSNP
rs777510977 3143 dbSNP
rs1460043008 3145 dbSNP
rs1374393375 3147 dbSNP
rs1425134892 3155 dbSNP
rs755826507 3173 dbSNP
rs1431904971 3174 dbSNP
rs959452738 3178 dbSNP
rs1395695061 3180 dbSNP
rs1419167965 3181 dbSNP
rs915901876 3188 dbSNP
rs1431249180 3189 dbSNP
rs1292689229 3191 dbSNP
rs991557642 3192 dbSNP
rs747781735 3194 dbSNP
rs1365429717 3196 dbSNP
rs960126508 3198 dbSNP
rs567143414 3200 dbSNP
rs1034113308 3208 dbSNP
rs1001338606 3215 dbSNP
rs547024741 3216 dbSNP
rs533546967 3225 dbSNP
rs188530237 3226 dbSNP
rs1237314026 3228 dbSNP
rs1287778930 3231 dbSNP
rs754521150 3232 dbSNP
rs1447184365 3240 dbSNP
rs1216997082 3242 dbSNP
rs977234401 3255 dbSNP
rs994225554 3258 dbSNP
rs1487793575 3273 dbSNP
rs1196126473 3278 dbSNP
rs1254160700 3281 dbSNP
rs967233991 3282 dbSNP
rs1021535931 3283 dbSNP
rs1011945862 3291 dbSNP
rs1163828468 3295 dbSNP
rs953034185 3302 dbSNP
rs772909925 3319 dbSNP
rs1326568298 3320 dbSNP
rs1453506979 3322 dbSNP
rs896858373 3324 dbSNP
rs750991734 3325 dbSNP
rs575217558 3330 dbSNP
rs1350975778 3334 dbSNP
rs1227316508 3339 dbSNP
rs1007946832 3353 dbSNP
rs1320354482 3360 dbSNP
rs1215916380 3368 dbSNP
rs2836352 3370 dbSNP
rs373105334 3372 dbSNP
rs561450707 3377 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Article - Xiao J; Luo X; Lin H; Zhang Y; Lu Y; Wang et al.
- The Journal of biological chemistry, 2007
We have previously found that the ether-a-go-go related gene (ERG), a long QT syndrome gene encoding a key K(+) channel (I(Kr)) in cardiac cells, is severely depressed in its expression at the protein level but not at the mRNA level in diabetic subjects. The mechanisms underlying the disparate alterations of ERG protein and mRNA, however, remained unknown. We report here a remarkable overexpression of miR-133 in hearts from a rabbit model of diabetes, and in parallel the expression of serum response factor (SRF), which is known to be a transactivator of miR-133, was also robustly increased. Delivery of exogenous miR-133 into the rabbit myocytes and cell lines produced post-transcriptional repression of ERG, down-regulating ERG protein level without altering its transcript level and caused substantial depression of I(Kr), an effect abrogated by the miR-133 antisense inhibitor. Functional inhibition or gene silencing of SRF down-regulated miR-133 expression and increased I(Kr) density. Repression of ERG by miR-133 likely underlies the differential changes of ERG protein and transcript thereby depression of I(Kr), and contributes to repolarization slowing thereby QT prolongation and the associated arrhythmias, in diabetic hearts. Our study provided the first evidence for the pathological role of miR-133 in adult hearts and thus expanded our understanding of the cellular function and pathophysiological roles of miRNAs.
LinkOut: [PMID: 17344217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRC 0.435 0 0.366 0 67 Click to see details
KIRP 0.583 0 0.576 0 30 Click to see details
HNSC 0.49 0 0.343 0.01 42 Click to see details
LIHC 0.456 0 0.391 0 49 Click to see details
ESCA 0.784 0 0.755 0 11 Click to see details
THCA 0.292 0.01 0.275 0.02 59 Click to see details
BRCA 0.247 0.02 0.344 0 77 Click to see details
STAD 0.365 0.02 0.306 0.04 32 Click to see details
KICH 0.401 0.03 0.410 0.02 24 Click to see details
COAD 0.589 0.06 0.643 0.04 8 Click to see details
PAAD -0.841 0.08 -1.000 0.5 4 Click to see details
PRAD -0.198 0.08 -0.238 0.05 50 Click to see details
UCEC 0.269 0.13 0.181 0.23 19 Click to see details
LUSC 0.14 0.2 0.140 0.2 38 Click to see details
BLCA 0.156 0.27 0.294 0.12 18 Click to see details
CHOL -0.119 0.38 -0.067 0.43 9 Click to see details
LUAD -0.054 0.43 0.035 0.46 12 Click to see details
PCPG -0.161 0.45 -0.500 0.33 3 Click to see details
CESC 0.085 0.47 0.500 0.33 3 Click to see details
CESC 0.085 0.47 0.500 0.33 3 Click to see details
CESC 0.085 0.47 0.500 0.33 3 Click to see details
122 hsa-miR-133a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000325 RHOA ras homolog family member A 1 2
MIRT000327 CDC42 cell division cycle 42 4 2
MIRT000328 ERG ERG, ETS transcription factor 1 1
MIRT000329 HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2 1
MIRT000330 UCP2 uncoupling protein 2 2 2
MIRT000331 KRT7 keratin 7 2 2
MIRT001203 CACNA1C calcium voltage-gated channel subunit alpha1 C 3 1
MIRT001204 HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 4 2
MIRT001816 PKM pyruvate kinase, muscle 1 1
MIRT001986 CASP9 caspase 9 3 3
MIRT002925 KCNQ1 potassium voltage-gated channel subfamily Q member 1 4 1
MIRT003542 FSCN1 fascin actin-bundling protein 1 5 4
MIRT004831 KCNH2 potassium voltage-gated channel subfamily H member 2 4 1
MIRT005604 TAGLN2 transgelin 2 5 4
MIRT005813 LASP1 LIM and SH3 protein 1 3 2
MIRT006571 PNP purine nucleoside phosphorylase 4 2
MIRT006680 MSN moesin 2 1
MIRT007032 EGFR epidermal growth factor receptor 3 5
MIRT007088 VKORC1 vitamin K epoxide reductase complex subunit 1 1 1
MIRT007383 PRDM16 PR/SET domain 16 1 2
MIRT021693 TPM1 tropomyosin 1 1 1
MIRT021695 FBN1 fibrillin 1 1 1
MIRT021696 FAM120C family with sequence similarity 120C 1 1
MIRT021697 BCAN brevican 1 1
MIRT021698 TCTEX1D2 Tctex1 domain containing 2 1 1
MIRT021699 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 1 1
MIRT021700 RFT1 RFT1 homolog 1 1
MIRT021701 SENP1 SUMO1/sentrin specific peptidase 1 1 1
MIRT021702 SMIM14 small integral membrane protein 14 1 1
MIRT021703 PRELID1 PRELI domain containing 1 1 1
MIRT021704 CNN2 calponin 2 3 3
MIRT021705 ARPC5 actin related protein 2/3 complex subunit 5 4 2
MIRT021706 FTL ferritin light chain 2 2
MIRT021707 CERS2 ceramide synthase 2 1 1
MIRT021708 SEC61B Sec61 translocon beta subunit 1 1
MIRT021709 PLEKHA3 pleckstrin homology domain containing A3 1 1
MIRT021710 EGFL7 EGF like domain multiple 7 1 1
MIRT021711 VEGFA vascular endothelial growth factor A 1 1
MIRT021712 PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 1 1
MIRT021713 RGS3 regulator of G protein signaling 3 1 1
MIRT021714 COL1A1 collagen type I alpha 1 chain 4 1
MIRT021715 GSTP1 glutathione S-transferase pi 1 2 1
MIRT035537 SP1 Sp1 transcription factor 2 2
MIRT035579 KLF15 Kruppel like factor 15 1 1
MIRT045837 NR4A2 nuclear receptor subfamily 4 group A member 2 1 1
MIRT052647 BCL2L1 BCL2 like 1 4 2
MIRT052648 MCL1 MCL1, BCL2 family apoptosis regulator 4 2
MIRT053333 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 4 1
MIRT054310 IGF1R insulin like growth factor 1 receptor 3 2
MIRT055599 FAM160B1 family with sequence similarity 160 member B1 2 2
MIRT081957 UBA2 ubiquitin like modifier activating enzyme 2 4 1
MIRT437400 MMP14 matrix metallopeptidase 14 3 1
MIRT437953 ANXA2 annexin A2 4 1
MIRT437954 SNX30 sorting nexin family member 30 4 1
MIRT437955 SGMS2 sphingomyelin synthase 2 4 1
MIRT438719 PDLIM5 PDZ and LIM domain 5 3 1
MIRT452802 PACS2 phosphofurin acidic cluster sorting protein 2 2 2
MIRT462823 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT468494 SESN2 sestrin 2 2 2
MIRT477714 EFHD2 EF-hand domain family member D2 2 2
MIRT483852 EMID1 EMI domain containing 1 2 2
MIRT490039 PRRT2 proline rich transmembrane protein 2 2 2
MIRT491349 CDKN1A cyclin dependent kinase inhibitor 1A 2 4
MIRT504443 MC2R melanocortin 2 receptor 2 2
MIRT505701 SESN3 sestrin 3 2 2
MIRT513521 RHOQ ras homolog family member Q 2 4
MIRT517423 HIST2H2AC histone cluster 2 H2A family member c 2 2
MIRT526599 DCAKD dephospho-CoA kinase domain containing 2 2
MIRT528904 THBS2 thrombospondin 2 2 2
MIRT533060 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT534126 SNX33 sorting nexin 33 2 2
MIRT534700 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 4
MIRT535732 MYPN myopalladin 2 2
MIRT538529 CHMP3 charged multivesicular body protein 3 2 4
MIRT550878 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT551260 PSMG1 proteasome assembly chaperone 1 2 2
MIRT551981 UGT2B10 UDP glucuronosyltransferase family 2 member B10 2 2
MIRT553866 SYAP1 synapse associated protein 1 2 2
MIRT558810 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 2
MIRT559367 ATP13A3 ATPase 13A3 2 2
MIRT560941 ZFP28 ZFP28 zinc finger protein 2 2
MIRT565461 SUPT16H SPT16 homolog, facilitates chromatin remodeling subunit 2 2
MIRT566234 PTMA prothymosin, alpha 2 2
MIRT568217 C11orf24 chromosome 11 open reading frame 24 2 2
MIRT608912 NCDN neurochondrin 2 6
MIRT613229 CCDC39 coiled-coil domain containing 39 2 2
MIRT623563 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT637224 TMEM59 transmembrane protein 59 2 2
MIRT641669 CCNI cyclin I 2 2
MIRT644440 ALDOC aldolase, fructose-bisphosphate C 2 2
MIRT644755 TXNRD3NB thioredoxin reductase 3 neighbor 2 2
MIRT646711 PDE1A phosphodiesterase 1A 2 2
MIRT647577 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT647760 RNF168 ring finger protein 168 2 2
MIRT649267 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT651238 ZMAT4 zinc finger matrin-type 4 2 2
MIRT652146 TRIM71 tripartite motif containing 71 2 2
MIRT657168 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT668302 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT687546 MLEC malectin 2 2
MIRT690857 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT697060 PSMC4 proteasome 26S subunit, ATPase 4 2 2
MIRT699725 SERPINH1 serpin family H member 1 2 2
MIRT700858 PER2 period circadian clock 2 2 2
MIRT705068 C4orf29 abhydrolase domain containing 18 2 2
MIRT709496 ANGPT4 angiopoietin 4 2 2
MIRT713925 PIGR polymeric immunoglobulin receptor 2 2
MIRT716058 SFTPB surfactant protein B 2 2
MIRT716724 APOL6 apolipoprotein L6 2 2
MIRT721677 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT723379 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT731340 IGF1 insulin like growth factor 1 1 1
MIRT731591 ZEB1 zinc finger E-box binding homeobox 1 1 1
MIRT732526 PTBP1 polypyrimidine tract binding protein 1 2 0
MIRT732527 KDM5C lysine demethylase 5C 2 0
MIRT732589 BCL2 BCL2, apoptosis regulator 2 0
MIRT732590 CASP3 caspase 3 2 0
MIRT733594 PPP2CA protein phosphatase 2 catalytic subunit alpha 3 0
MIRT735355 MB myoglobin 1 0
MIRT735744 CDCA8 cell division cycle associated 8 3 0
MIRT736984 SET SET nuclear proto-oncogene 1 0
MIRT737550 TGFB1 transforming growth factor beta 1 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-133a Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-133a Proanthocyanin NULL 108065 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-133a Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-133a Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-133a Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miR-133a Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miR-133a Benzene NULL 241 MiRNA PCR array white blood cell 24780745 2014 down-regulated
miR-133a Benzene NULL 241 MiRNA PCR array blood mononuclear cells 24780745 2014 down-regulated
miR-133a Ibandronate approved 60852 Quantitative real-time PCR Periodontal ligament stem cells (PDLSCs) 21108928 2011 down-regulated
miR-133a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-133a Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-133a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 down-regulated
miR-133a Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-133a Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-133a 5-Fluorouracil approved 3385 Quantitative real-time PCR colon cancer cells 17702597 2007 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H358, H1993)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H1155, H358, H1993)
hsa-miR-133a-3p Sunitinib 5329102 NSC750690 approved resistant High Metastatic Renal Cell Carcinoma tissue and cell line (Caki-2)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant Low Esophageal Squamous Cell Carcinoma tissue
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Head And Neck Squamous Cell Carcinoma cell line (Hep-2, NP69)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer tissue
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Urothelial Bladder Cancer cell line (T24)
hsa-miR-133a-3p Gemcitabine 60750 NSC613327 approved sensitive Low Urothelial Bladder Cancer cell line (T24)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant Low Prostate Cancer cell line (PC-3-R)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved sensitive Low Nasopharyngeal Cancer cell line (HONE1, SUNE1)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer cell line (MGC-803)
hsa-miR-133a-3p Bromocriptine 31101 NSC169774 approved resistant Low Prolactinoma tissue
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-133a-3p Gefitinib 123631 NSC715055 approved sensitive Low Non-Small Cell Lung Cancer cell line (PC-9)
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Etoposide 36462 NSC141540 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Vinorelbine 44424639 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Vincristine 5978 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (SKOV3, A2780)
hsa-miR-133a-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-133a-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-133a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-133a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-133a-3p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-133a-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-133a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-133a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine sensitive cell line (Bats-72)

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