miRTarBase - #MIRT000496


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pre-miRNA Information
pre-miRNA hsa-mir-519c   
Genomic Coordinates chr19: 53686469 - 53686555
Description Homo sapiens miR-519c stem-loop
Comment The 5' arm of this precursor expresses a product related to miR-526 (previously named miR-526c here). Landgraf et al. confirm mature miRNA expression from both arms of the precursor .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-519c-3p
Sequence 54| AAAGUGCAUCUUUUUAGAGGAU |75
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 19 + 53686523 29233923 MiREDiBase
A-to-I 3 19 + 53686524 29233923 MiREDiBase
A-to-I 8 19 + 53686529 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1164669230 4 dbSNP
rs764425172 8 dbSNP
rs1377433094 10 dbSNP
rs751997873 19 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HIF1A   
Synonyms HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
Description hypoxia inducible factor 1 alpha subunit
Transcript NM_181054   
Other Transcripts NM_001530   
Expression
Putative miRNA Targets on HIF1A
3'UTR of HIF1A
(miRNA target sites are highlighted)		 
>HIF1A|NM_181054|3'UTR
   1 CATGTAGACTGCTGGGGCAATCAATGGATGAAAGTGGATTACCACAGCTGACCAGTTATGATTGTGAAGTTAATGCTCCT
  81 ATACAAGGCAGCAGAAACCTACTGCAGGGTGAAGAATTACTCAGAGCTTTGGATCAAGTTAACTGAGCTTTTTCTTAATT
 161 TCATTCCTTTTTTTGGACACTGGTGGCTCATTACCTAAAGCAGTCTATTTATATTTTCTACATCTAATTTTAGAAGCCTG
 241 GCTACAATACTGCACAAACTTGGTTAGTTCAATTTTGATCCCCTTTCTACTTAATTTACATTAATGCTCTTTTTTAGTAT
 321 GTTCTTTAATGCTGGATCACAGACAGCTCATTTTCTCAGTTTTTTGGTATTTAAACCATTGCATTGCAGTAGCATCATTT
 401 TAAAAAATGCACCTTTTTATTTATTTATTTTTGGCTAGGGAGTTTATCCCTTTTTCGAATTATTTTTAAGAAGATGCCAA
 481 TATAATTTTTGTAAGAAGGCAGTAACCTTTCATCATGATCATAGGCAGTTGAAAAATTTTTACACCTTTTTTTTCACATT
 561 TTACATAAATAATAATGCTTTGCCAGCAGTACGTGGTAGCCACAATTGCACAATATATTTTCTTAAAAAATACCAGCAGT
 641 TACTCATGGAATATATTCTGCGTTTATAAAACTAGTTTTTAAGAAGAAATTTTTTTTGGCCTATGAAATTGTTAAACCTG
 721 GAACATGACATTGTTAATCATATAATAATGATTCTTAAATGCTGTATGGTTTATTATTTAAATGGGTAAAGCCATTTACA
 801 TAATATAGAAAGATATGCATATATCTAGAAGGTATGTGGCATTTATTTGGATAAAATTCTCAATTCAGAGAAATCATCTG
 881 ATGTTTCTATAGTCACTTTGCCAGCTCAAAAGAAAACAATACCCTATGTAGTTGTGGAAGTTTATGCTAATATTGTGTAA
 961 CTGATATTAAACCTAAATGTTCTGCCTACCCTGTTGGTATAAAGATATTTTGAGCAGACTGTAAACAAGAAAAAAAAAAT
1041 CATGCATTCTTAGCAAAATTGCCTAGTATGTTAATTTGCTCAAAATACAATGTTTGATTTTATGCACTTTGTCGCTATTA
1121 ACATCCTTTTTTTCATGTAGATTTCAATAATTGAGTAATTTTAGAAGCATTATTTTAGGAATATATAGTTGTCACAGTAA
1201 ATATCTTGTTTTTTCTATGTACATTGTACAAATTTTTCATTCCTTTTGCTCTTTGTGGTTGGATCTAACACTAACTGTAT
1281 TGTTTTGTTACATCAAATAAACATCTTCTGTGGACCAGGCAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaggAGAUUUUUCUACGUGAAa 5'
              |:|:|    |||||||| 
Target 5' aatgTTTGATTTTATGCACTTt 3'
 1089 - 1110 150.00 -10.50
2 
miRNA  3' uagGAGAUUUUUCUACGUGAAa 5'
             :|:|||||| |||||| | 
Target 5' tcaTTTTAAAAA-ATGCACCTt 3'
 395 - 415 142.00 -10.52
3 
miRNA  3' uaggagaUUUUUCUACGUGAaa 5'
                 ||||  |||||:|  
Target 5' gaaaaaaAAAATCATGCATTct 3'
 1029 - 1050 123.00 -6.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
709474 18 ClinVar
COSM8236443 25 COSMIC
COSM2247247 35 COSMIC
COSM956814 48 COSMIC
COSM2247248 50 COSMIC
COSM1159287 53 COSMIC
COSM9470578 72 COSMIC
COSM3386615 73 COSMIC
COSM7702681 79 COSMIC
COSM8720098 82 COSMIC
COSM1158010 89 COSMIC
COSM4577931 90 COSMIC
COSM6328155 92 COSMIC
COSM4636919 104 COSMIC
COSN31598380 154 COSMIC
COSN22510195 156 COSMIC
COSN30146484 163 COSMIC
COSN30479229 168 COSMIC
COSN5853537 175 COSMIC
COSN20389672 179 COSMIC
COSN31497155 184 COSMIC
COSN20087972 192 COSMIC
COSN30511452 209 COSMIC
COSN26307819 237 COSMIC
COSN30166240 249 COSMIC
COSN31513196 252 COSMIC
COSN21620339 254 COSMIC
COSN24313377 271 COSMIC
COSN20111388 277 COSMIC
COSN20066277 279 COSMIC
COSN30524741 305 COSMIC
COSN31535736 366 COSMIC
COSN26581982 390 COSMIC
COSN31595948 448 COSMIC
COSN31569975 458 COSMIC
COSN26586676 500 COSMIC
COSN31611055 608 COSMIC
COSN30541333 683 COSMIC
COSN18936091 787 COSMIC
COSN31585350 813 COSMIC
COSN23687473 821 COSMIC
COSN8846910 826 COSMIC
COSN31547288 871 COSMIC
COSN31606639 871 COSMIC
COSN9089004 881 COSMIC
COSN31484977 897 COSMIC
COSN29683013 1040 COSMIC
COSN21324998 1080 COSMIC
COSN1169739 1134 COSMIC
COSN31593408 1215 COSMIC
COSN31516638 1232 COSMIC
COSN31563647 1316 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs539549822 5 dbSNP
rs772563698 15 dbSNP
rs74054863 18 dbSNP
rs761301966 25 dbSNP
rs764342882 27 dbSNP
rs1434107649 30 dbSNP
rs777173441 32 dbSNP
rs148149561 45 dbSNP
rs762084100 46 dbSNP
rs1332732959 48 dbSNP
rs1400361157 51 dbSNP
rs1802821 52 dbSNP
rs765575235 56 dbSNP
rs545874061 60 dbSNP
rs762942023 63 dbSNP
rs758032673 64 dbSNP
rs1294810529 71 dbSNP
rs1315936022 72 dbSNP
rs1220369809 75 dbSNP
rs1354416944 79 dbSNP
rs1002016670 80 dbSNP
rs1258843938 82 dbSNP
rs1334246808 84 dbSNP
rs766542880 85 dbSNP
rs140173615 90 dbSNP
rs754986249 92 dbSNP
rs780928465 93 dbSNP
rs559651239 99 dbSNP
rs145319047 103 dbSNP
rs1325345716 105 dbSNP
rs1172010116 111 dbSNP
rs1295805684 112 dbSNP
rs1423792468 115 dbSNP
rs1434851318 120 dbSNP
rs1366526923 127 dbSNP
rs1404187796 128 dbSNP
rs1162266976 129 dbSNP
rs777407997 132 dbSNP
rs759636243 142 dbSNP
rs1389320297 145 dbSNP
rs770333662 146 dbSNP
rs371720529 148 dbSNP
rs1387964413 149 dbSNP
rs1338114141 152 dbSNP
rs778533208 153 dbSNP
rs747441284 156 dbSNP
rs1026312234 157 dbSNP
rs552985977 165 dbSNP
rs371778537 166 dbSNP
rs769316153 167 dbSNP
rs1292325060 168 dbSNP
rs779790779 168 dbSNP
rs780828413 168 dbSNP
rs1322499060 169 dbSNP
rs1215298795 173 dbSNP
rs1284371531 178 dbSNP
rs1489469817 181 dbSNP
rs777085247 182 dbSNP
rs762278418 186 dbSNP
rs1472198228 188 dbSNP
rs2057482 192 dbSNP
rs773559645 194 dbSNP
rs763289041 196 dbSNP
rs1210541354 200 dbSNP
rs542082268 202 dbSNP
rs750111993 208 dbSNP
rs964865492 222 dbSNP
rs978881402 231 dbSNP
rs1272811246 236 dbSNP
rs775751381 241 dbSNP
rs1343396726 242 dbSNP
rs561963703 247 dbSNP
rs1272414694 248 dbSNP
rs983334130 253 dbSNP
rs1033251976 254 dbSNP
rs769353565 258 dbSNP
rs1406298050 263 dbSNP
rs530984621 263 dbSNP
rs1203608510 264 dbSNP
rs549497743 268 dbSNP
rs1307099949 270 dbSNP
rs1249381070 271 dbSNP
rs199915104 273 dbSNP
rs397897404 273 dbSNP
rs5809121 273 dbSNP
rs913568799 283 dbSNP
rs563032969 292 dbSNP
rs1477633716 294 dbSNP
rs949034822 299 dbSNP
rs981877125 300 dbSNP
rs949635893 307 dbSNP
rs1199642529 325 dbSNP
rs1249880441 333 dbSNP
rs532181605 337 dbSNP
rs551891037 355 dbSNP
rs1483509684 356 dbSNP
rs982365060 360 dbSNP
rs926344697 373 dbSNP
rs1199119871 377 dbSNP
rs937859002 380 dbSNP
rs926624286 385 dbSNP
rs1224815816 389 dbSNP
rs1348150414 390 dbSNP
rs938038646 399 dbSNP
rs1200937897 402 dbSNP
rs1037532137 403 dbSNP
rs1331894483 404 dbSNP
rs1413747297 419 dbSNP
rs1053786420 437 dbSNP
rs1170221751 456 dbSNP
rs893855163 457 dbSNP
rs763243537 458 dbSNP
rs1432176686 460 dbSNP
rs1309109880 463 dbSNP
rs1041908240 464 dbSNP
rs1473015674 478 dbSNP
rs1365494899 481 dbSNP
rs565632163 483 dbSNP
rs1403254921 486 dbSNP
rs151303260 487 dbSNP
rs1442274612 490 dbSNP
rs1297315230 492 dbSNP
rs1279938106 502 dbSNP
rs1008558586 508 dbSNP
rs17099190 518 dbSNP
rs1019564762 521 dbSNP
rs1266893123 522 dbSNP
rs140525186 530 dbSNP
rs1293213243 547 dbSNP
rs996483325 547 dbSNP
rs1026672127 555 dbSNP
rs1308966626 556 dbSNP
rs1048073800 558 dbSNP
rs1291015828 559 dbSNP
rs952532711 564 dbSNP
rs890474693 593 dbSNP
rs1401402955 594 dbSNP
rs1410435090 597 dbSNP
rs1161740541 598 dbSNP
rs1472599652 599 dbSNP
rs1246737090 602 dbSNP
rs1185844172 608 dbSNP
rs982562264 613 dbSNP
rs1248001518 615 dbSNP
rs1485359835 632 dbSNP
rs186070865 634 dbSNP
rs1184337665 636 dbSNP
rs1008828153 640 dbSNP
rs1016170938 640 dbSNP
rs970960593 648 dbSNP
rs1017666271 649 dbSNP
rs900581021 662 dbSNP
rs1356614289 663 dbSNP
rs982312779 665 dbSNP
rs1432702227 675 dbSNP
rs1417832408 681 dbSNP
rs1321218907 682 dbSNP
rs112980101 690 dbSNP
rs1431556853 704 dbSNP
rs537228141 710 dbSNP
rs1346981030 713 dbSNP
rs1000351887 718 dbSNP
rs926907138 723 dbSNP
rs751806225 725 dbSNP
rs1165838369 735 dbSNP
rs1448086868 741 dbSNP
rs1305448254 742 dbSNP
rs1390096297 743 dbSNP
rs1451785185 746 dbSNP
rs1169620714 749 dbSNP
rs1385201243 757 dbSNP
rs1033135776 762 dbSNP
rs1225899795 769 dbSNP
rs1293545948 769 dbSNP
rs1423265139 771 dbSNP
rs34873475 778 dbSNP
rs1341271847 783 dbSNP
rs1325634233 787 dbSNP
rs956362576 792 dbSNP
rs8019084 794 dbSNP
rs762252347 801 dbSNP
rs945443994 815 dbSNP
rs1042515017 817 dbSNP
rs1287270892 822 dbSNP
rs767862625 837 dbSNP
rs1428202134 847 dbSNP
rs1370274736 867 dbSNP
rs1228951010 872 dbSNP
rs1314065298 879 dbSNP
rs1357227551 887 dbSNP
rs981762514 890 dbSNP
rs1430768103 891 dbSNP
rs1248034618 893 dbSNP
rs926396778 900 dbSNP
rs1040910292 902 dbSNP
rs879291501 913 dbSNP
rs996771147 922 dbSNP
rs973110354 926 dbSNP
rs952877554 928 dbSNP
rs920448595 933 dbSNP
rs929103345 935 dbSNP
rs1310343873 936 dbSNP
rs1048503409 937 dbSNP
rs1047656959 953 dbSNP
rs888154356 954 dbSNP
rs1346293284 962 dbSNP
rs190860864 967 dbSNP
rs1408156600 985 dbSNP
rs1350131716 994 dbSNP
rs1299083231 995 dbSNP
rs1242865466 996 dbSNP
rs944737744 1000 dbSNP
rs1463890765 1001 dbSNP
rs539881963 1005 dbSNP
rs773972883 1016 dbSNP
rs1357928211 1020 dbSNP
rs1443359225 1027 dbSNP
rs1176055068 1028 dbSNP
rs1470597308 1029 dbSNP
rs1015368010 1030 dbSNP
rs1430709945 1030 dbSNP
rs971292665 1030 dbSNP
rs1165437560 1040 dbSNP
rs1039002996 1041 dbSNP
rs1178692650 1042 dbSNP
rs1414641588 1054 dbSNP
rs750960087 1073 dbSNP
rs900632992 1082 dbSNP
rs534696980 1085 dbSNP
rs867054308 1090 dbSNP
rs180837209 1091 dbSNP
rs1033476211 1093 dbSNP
rs1308063073 1106 dbSNP
rs573160553 1111 dbSNP
rs891975089 1114 dbSNP
rs989725139 1115 dbSNP
rs1436031645 1119 dbSNP
rs915224690 1120 dbSNP
rs1408971422 1124 dbSNP
rs186481938 1126 dbSNP
rs978566180 1127 dbSNP
rs1010804073 1132 dbSNP
rs370476266 1133 dbSNP
rs1364013357 1134 dbSNP
rs1160909738 1137 dbSNP
rs1421701348 1142 dbSNP
rs114812759 1148 dbSNP
rs1024591004 1149 dbSNP
rs756658648 1152 dbSNP
rs972050428 1154 dbSNP
rs1003250403 1157 dbSNP
rs1380222271 1165 dbSNP
rs1450147761 1166 dbSNP
rs1033348128 1186 dbSNP
rs574800089 1193 dbSNP
rs1206902487 1198 dbSNP
rs958994442 1203 dbSNP
rs1350125414 1205 dbSNP
rs778376665 1208 dbSNP
rs1241371052 1209 dbSNP
rs911949361 1209 dbSNP
rs944788994 1209 dbSNP
rs920314952 1218 dbSNP
rs1314742202 1220 dbSNP
rs1385575406 1224 dbSNP
rs1433694893 1247 dbSNP
rs752265561 1252 dbSNP
rs983676896 1259 dbSNP
rs555623016 1262 dbSNP
rs921108454 1264 dbSNP
rs1446294210 1287 dbSNP
rs1269456542 1289 dbSNP
rs765677998 1292 dbSNP
rs1447522222 1300 dbSNP
rs1262471493 1302 dbSNP
rs1206996164 1309 dbSNP
rs561456816 1312 dbSNP
rs1487616499 1317 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions A549 , MDA-MB-231 , CL1-0 , CL1-5
Location of target site 3'UTR
Tools used in this research TargetScan , RNAhybrid , PicTar
Original Description (Extracted from the article) ... "MicroRNA-519c Suppresses Hypoxia-Inducible Factor-1脦卤 Expression and Tumor Angiogenesis//we have identified miR-519c as a hypoxia-independent regulator of HIF-1脦卤 ...

- Cha ST; Chen PS; Johansson G; Chu CY; Wang et al., 2010, Cancer research.

Article - Cha ST; Chen PS; Johansson G; Chu CY; Wang et al.
- Cancer research, 2010
Hypoxia-inducible factor-1alpha (HIF-1alpha) is widely considered to be one of the key regulators of tumor angiogenesis. The upstream regulation is complex and involves several growth factors, cytokines, and hypoxia. Herein, we have identified miR-519c as a hypoxia-independent regulator of HIF-1alpha, acting through direct binding to the HIF-1alpha 3' untranslated region and leading to reduced tumor angiogenesis. Overexpression of miR-519c resulted in a significant decrease of HIF-1alpha protein levels and reduced the tube formation of human umbilical vein endothelial cells; similarly, antagomir inhibition of miR-519c increased the level of HIF-1alpha protein and enhanced angiogenic activity, suggesting an important role of miR-519c in HIF-1alpha-mediated angiogenesis. Consistent with the overexpression of miR-519c in cancer patients with better prognosis, mice injected with miR-519c-overexpressing cells exhibited dramatically reduced HIF-1alpha levels, followed by suppressed tumor angiogenesis, growth, and metastasis. In addition, we found that hepatocyte growth factor (HGF), a known HIF-1alpha inducer, reduced the miR-519c levels through an Akt-dependent pathway. This regulation was posttranscriptional and may be mediated by suppression of miR-519c maturation. Taken together, our findings provide the first evidence that miR-519c is a pivotal regulator of tumor angiogenesis and that microenvironmental HGF contributes to regulating miR-519c biogenesis in cancer cells.
LinkOut: [PMID: 20233879]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001530 | 3UTR | GAUAUUAAACCUAAAUGUUCUGCCUACCCUGUUGGUAUAAAGAUAUUUUGAGCAGACUGUAAACAAGAAAAAAAAAAUCAUGCAUUCUUAGCAAAAUUGCCUAGUAUGUUAAUUUGCUCAAAAUACAAUGUUUGAUUUUAUGCACUUUGUCGCUAUUAACAUCCUUUUUUUCAUGUAGAUUUCAAUAAUUGAGUAAUUUUAGAAGCAUUAUUUUAGGAAUAUAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001530 | 3UTR | AUAAAGAUAUUUUGAGCAGACUGUAAACAAGAAAAAAAAAAUCAUGCAUUCUUAGCAAAAUUGCCUAGUAUGUUAAUUUGCUCAAAAUACAAUGUUUGAUUUUAUGCACUUUGUCGCUAUUAACAUCCUUUUUUUCAUGUAGAUUUCAAUAAUUGAGUAAUUUUAGAAGCAUUAUUUUAGGAAUAUAUAGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001530 | 3UTR | UUCUGCCUACCCUGUUGGUAUAAAGAUAUUUUGAGCAGACUGUAAACAAGAAAAAAAAAAUCAUGCAUUCUUAGCAAAAUUGCCUAGUAUGUUAAUUUGCUCAAAAUACAAUGUUUGAUUUUAUGCACUUUGUCGCUAUUAACAUCCUUUUUUUCAUGUAGAUUUCAAUAAUUGAGUAAUUUUAGAAGCAUUAUUUUAGGAAUAUAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001530 | 3UTR | AAUGUUCUGCCUACCCUGUUGGUAUAAAGAUAUUUUGAGCAGACUGUAAACAAGAAAAAAAAAAUCAUGCAUUCUUAGCAAAAUUGCCUAGUAUGUUAAUUUGCUCAAAAUACAAUGUUUGAUUUUAUGCACUUUGUCGCUAUUAACAUCCUUUUUUUCAUGUAGAUUUCAAUAAUUGAGUAAUUUUAGAAGCAUUAUUUUAGGAAUAUAUAGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001530 | 3UTR | GCAUUCUUAGCAAAAUUGCCUAGUAUGUUAAUUUGCUCAAAAUACAAUGUUUGAUUUUAUGCACUUUGUCGCUAUUAACAUCCUUUUUUUCAUGUAGAUUUCAAUAAUUGAGUAAUUUUAGAAGCAUUAUUUUAGGAAUAUAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001530 | 3UTR | UGUUCUGCCUACCCUGUUGGUAUAAAGAUAUUUUGAGCAGACUGUAAACAAGAAAAAAAAAAUCAUGCAUUCUUAGCAAAAUUGCCUAGUAUGUUAAUUUGCUCAAAAUACAAUGUUUGAUUUUAUGCACUUUGUCGCUAUUAACAUCCUUUUUUUCAUGUAGAUUUCAAUAAUUGAGUAAUUUUAGAAGCAUUAUUUUAGGAAUAUAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38974 Chronic obstructive pulmonary disease 0.481 7.5e-3 0.491 6.3e-3 25 Click to see details
GSE32688 Pancreatic cancer -0.331 3.2e-2 -0.339 2.9e-2 32 Click to see details
GSE38226 Liver fibrosis -0.362 5.3e-2 -0.077 3.7e-1 21 Click to see details
GSE28544 Breast cancer 0.238 1.3e-1 0.331 5.7e-2 24 Click to see details
GSE27834 Pluripotent stem cells 0.288 1.4e-1 0.253 1.7e-1 16 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.433 1.4e-1 -0.452 1.3e-1 8 Click to see details
GSE17498 Multiple myeloma -0.163 1.6e-1 -0.151 1.8e-1 40 Click to see details
GSE21849 B cell lymphoma -0.181 1.7e-1 0.093 3.2e-1 29 Click to see details
GSE28260 Renal cortex and medulla 0.267 1.9e-1 0.308 1.5e-1 13 Click to see details
GSE17306 Multiple myeloma -0.077 3.0e-1 0.453 5.4e-4 49 Click to see details
GSE14794 Lymphoblastoid cells -0.056 3.0e-1 -0.120 1.3e-1 90 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.095 3.3e-1 0.349 4.4e-2 25 Click to see details
GSE26953 Aortic valvular endothelial cells -0.092 3.3e-1 -0.057 4.0e-1 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.059 3.9e-1 -0.157 2.4e-1 23 Click to see details
GSE19350 CNS germ cell tumors -0.051 4.4e-1 0.044 4.5e-1 12 Click to see details
GSE21687 Ependynoma primary tumors -0.009 4.7e-1 -0.001 5.0e-1 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.012 4.8e-1 -0.547 6.3e-3 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.591 0.15 0.800 0.05 5 Click to see details
LIHC -0.66 0.17 -0.400 0.3 4 Click to see details
HNSC -0.463 0.35 -0.500 0.33 3 Click to see details
HNSC -0.463 0.35 -0.500 0.33 3 Click to see details
HNSC -0.463 0.35 -0.500 0.33 3 Click to see details
HNSC -0.463 0.35 -0.500 0.33 3 Click to see details
325 hsa-miR-519c-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000496 HIF1A hypoxia inducible factor 1 alpha subunit 4 1
MIRT000998 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 4 3
MIRT003732 ELAVL1 ELAV like RNA binding protein 1 3 1
MIRT006639 TIMP2 TIMP metallopeptidase inhibitor 2 3 1
MIRT006640 PTEN phosphatase and tensin homolog 3 1
MIRT006641 CDKN1A cyclin dependent kinase inhibitor 1A 3 1
MIRT055028 TPRG1L tumor protein p63 regulated 1 like 2 2
MIRT055393 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT056828 REEP3 receptor accessory protein 3 2 2
MIRT060504 PPP6R3 protein phosphatase 6 regulatory subunit 3 2 2
MIRT061796 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 10
MIRT063354 ETNK1 ethanolamine kinase 1 2 2
MIRT064424 ARID4B AT-rich interaction domain 4B 2 2
MIRT064719 CCND2 cyclin D2 2 2
MIRT064805 ZBTB18 zinc finger and BTB domain containing 18 2 4
MIRT065609 DAZAP2 DAZ associated protein 2 2 10
MIRT065622 CLIC4 chloride intracellular channel 4 2 4
MIRT065872 GDF11 growth differentiation factor 11 2 2
MIRT065892 RAB5B RAB5B, member RAS oncogene family 2 8
MIRT068751 RB1 RB transcriptional corepressor 1 2 2
MIRT070050 FANCM Fanconi anemia complementation group M 2 2
MIRT071004 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT071334 CMPK1 cytidine/uridine monophosphate kinase 1 2 6
MIRT071912 ZFYVE9 zinc finger FYVE-type containing 9 2 2
MIRT072732 GLCE glucuronic acid epimerase 2 2
MIRT076028 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 6
MIRT076046 PITPNA phosphatidylinositol transfer protein alpha 2 2
MIRT079353 CCDC137 coiled-coil domain containing 137 2 2
MIRT080227 SMAD4 SMAD family member 4 2 6
MIRT081122 LDLR low density lipoprotein receptor 2 8
MIRT081205 MIDN midnolin 2 10
MIRT085098 IFNAR2 interferon alpha and beta receptor subunit 2 2 6
MIRT085149 SLC5A3 solute carrier family 5 member 3 2 4
MIRT086436 NABP1 nucleic acid binding protein 1 2 6
MIRT088037 UBXN2A UBX domain protein 2A 2 2
MIRT088132 SEPT2 septin 2 2 4
MIRT088343 MAPRE3 microtubule associated protein RP/EB family member 3 2 8
MIRT090645 U2SURP U2 snRNP associated SURP domain containing 2 6
MIRT090805 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT091692 TGFBR2 transforming growth factor beta receptor 2 2 4
MIRT092689 C3ORF38 chromosome 3 open reading frame 38 2 8
MIRT093954 SLAIN2 SLAIN motif family member 2 2 2
MIRT095727 ANKH ANKH inorganic pyrophosphate transport regulator 2 8
MIRT097158 FCHO2 FCH domain only 2 2 2
MIRT099319 QKI QKI, KH domain containing RNA binding 2 4
MIRT099835 SOX4 SRY-box 4 2 10
MIRT100773 ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2 2
MIRT100955 CENPQ centromere protein Q 2 4
MIRT102229 HBP1 HMG-box transcription factor 1 2 2
MIRT102299 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT102621 UBN2 ubinuclein 2 2 8
MIRT103780 PURB purine rich element binding protein B 2 2
MIRT104168 PHTF2 putative homeodomain transcription factor 2 2 6
MIRT107279 FAM73B mitoguardin 2 2 2
MIRT107945 TMEM2 transmembrane protein 2 2 2
MIRT108265 HABP4 hyaluronan binding protein 4 2 2
MIRT124812 BICD2 BICD cargo adaptor 2 2 2
MIRT138707 MPP5 membrane palmitoylated protein 5 2 2
MIRT139880 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT144312 NFAT5 nuclear factor of activated T-cells 5 2 8
MIRT145605 LASP1 LIM and SH3 protein 1 2 2
MIRT153350 MAVS mitochondrial antiviral signaling protein 2 4
MIRT153986 PRNP prion protein 2 2
MIRT159129 NRBP1 nuclear receptor binding protein 1 2 2
MIRT164533 MSMO1 methylsterol monooxygenase 1 2 2
MIRT165912 CREBRF CREB3 regulatory factor 2 2
MIRT170858 TAX1BP1 Tax1 binding protein 1 2 4
MIRT172157 FZD6 frizzled class receptor 6 2 8
MIRT173701 PRPF4 pre-mRNA processing factor 4 2 2
MIRT175003 ZBTB5 zinc finger and BTB domain containing 5 2 4
MIRT175400 ACSL4 acyl-CoA synthetase long chain family member 4 2 2
MIRT178069 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT178675 FAM102B family with sequence similarity 102 member B 2 2
MIRT180847 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 4
MIRT194911 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT195755 ATMIN ATM interactor 2 6
MIRT196623 TAOK1 TAO kinase 1 2 6
MIRT205286 STK11IP serine/threonine kinase 11 interacting protein 2 2
MIRT206051 PPARA peroxisome proliferator activated receptor alpha 2 2
MIRT206198 RAB10 RAB10, member RAS oncogene family 2 4
MIRT208980 SKIL SKI like proto-oncogene 2 10
MIRT223637 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT224757 DPYSL2 dihydropyrimidinase like 2 2 2
MIRT227995 NFIB nuclear factor I B 2 4
MIRT230973 PRRG4 proline rich and Gla domain 4 2 2
MIRT238183 ANKRD33B ankyrin repeat domain 33B 2 10
MIRT242425 HAS3 hyaluronan synthase 3 2 2
MIRT242666 SALL3 spalt like transcription factor 3 2 4
MIRT242765 FNBP1L formin binding protein 1 like 2 6
MIRT243095 LCLAT1 lysocardiolipin acyltransferase 1 2 4
MIRT243437 PAK2 p21 (RAC1) activated kinase 2 2 2
MIRT243964 MAP1B microtubule associated protein 1B 2 2
MIRT244776 RABGAP1 RAB GTPase activating protein 1 2 2
MIRT246630 TMEM109 transmembrane protein 109 2 2
MIRT246968 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT266055 FJX1 four jointed box 1 2 4
MIRT266858 SLC25A44 solute carrier family 25 member 44 2 2
MIRT283184 C16ORF52 chromosome 16 open reading frame 52 2 2
MIRT286955 SOCS7 suppressor of cytokine signaling 7 2 2
MIRT293651 PVR poliovirus receptor 2 4
MIRT295178 ZNF317 zinc finger protein 317 2 4
MIRT302453 CLIP4 CAP-Gly domain containing linker protein family member 4 2 2
MIRT303499 NAGK N-acetylglucosamine kinase 2 6
MIRT368755 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT383207 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT383610 POU2F1 POU class 2 homeobox 1 2 2
MIRT396102 CASP2 caspase 2 2 2
MIRT441419 FAM9C family with sequence similarity 9 member C 2 2
MIRT446818 C5orf30 chromosome 5 open reading frame 30 2 2
MIRT448307 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT461781 MPDU1 mannose-P-dolichol utilization defect 1 2 2
MIRT462816 NTN1 netrin 1 2 2
MIRT463613 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT464560 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT464842 RPS27A ribosomal protein S27a 2 12
MIRT465225 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT466446 TFAM transcription factor A, mitochondrial 2 8
MIRT466836 STX6 syntaxin 6 2 6
MIRT467185 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468179 SGMS1 sphingomyelin synthase 1 2 2
MIRT469850 PXK PX domain containing serine/threonine kinase like 2 8
MIRT471612 PAQR5 progestin and adipoQ receptor family member 5 2 19
MIRT472008 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT472159 NIN ninein 2 4
MIRT472336 NETO2 neuropilin and tolloid like 2 2 4
MIRT473162 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT473623 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT473682 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT473805 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT474416 KLHL28 kelch like family member 28 2 8
MIRT474736 KIF13A kinesin family member 13A 2 6
MIRT474966 KCTD10 potassium channel tetramerization domain containing 10 2 4
MIRT475464 HSPA8 heat shock protein family A (Hsp70) member 8 2 6
MIRT476120 GPR157 G protein-coupled receptor 157 2 2
MIRT476203 GNS glucosamine (N-acetyl)-6-sulfatase 2 6
MIRT477180 F3 coagulation factor III, tissue factor 2 8
MIRT478103 DLG5 discs large MAGUK scaffold protein 5 2 6
MIRT478713 CSNK1A1 casein kinase 1 alpha 1 2 6
MIRT479055 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 8
MIRT480008 CAPRIN2 caprin family member 2 2 4
MIRT480519 C11orf30 EMSY, BRCA2 interacting transcriptional repressor 2 10
MIRT480822 BLCAP bladder cancer associated protein 2 10
MIRT480944 BBX BBX, HMG-box containing 2 8
MIRT481336 ATL3 atlastin GTPase 3 2 2
MIRT481598 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT481877 ANKRD50 ankyrin repeat domain 50 2 2
MIRT482471 ADAR adenosine deaminase, RNA specific 2 4
MIRT484875 ZNF652 zinc finger protein 652 2 2
MIRT485090 SLC30A1 solute carrier family 30 member 1 2 4
MIRT485579 FOXQ1 forkhead box Q1 2 2
MIRT485618 FBXL5 F-box and leucine rich repeat protein 5 2 10
MIRT486751 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT489599 ZDHHC20 zinc finger DHHC-type containing 20 2 10
MIRT489889 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT491654 PDRG1 p53 and DNA damage regulated 1 2 10
MIRT492038 TSG101 tumor susceptibility 101 2 4
MIRT492361 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT492776 PDGFB platelet derived growth factor subunit B 2 2
MIRT493336 LAPTM4A lysosomal protein transmembrane 4 alpha 2 12
MIRT493611 HMGB3 high mobility group box 3 2 6
MIRT497468 DDR2 discoidin domain receptor tyrosine kinase 2 2 2
MIRT498059 SNX5 sorting nexin 5 2 6
MIRT499901 KIAA1191 KIAA1191 2 4
MIRT500489 ZBTB4 zinc finger and BTB domain containing 4 2 6
MIRT500685 TRIM37 tripartite motif containing 37 2 2
MIRT500760 TMEM127 transmembrane protein 127 2 6
MIRT501456 PTPN4 protein tyrosine phosphatase, non-receptor type 4 2 8
MIRT501559 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501983 MAPK1 mitogen-activated protein kinase 1 2 10
MIRT502000 MAP7 microtubule associated protein 7 2 8
MIRT502049 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 6
MIRT502423 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT503044 CAMSAP2 calmodulin regulated spectrin associated protein family member 2 2 2
MIRT503821 TMEM242 transmembrane protein 242 2 4
MIRT504290 PARP1 poly(ADP-ribose) polymerase 1 2 6
MIRT504560 ZNF417 zinc finger protein 417 2 6
MIRT505054 ZNF202 zinc finger protein 202 2 6
MIRT505486 SRSF2 serine and arginine rich splicing factor 2 2 4
MIRT505836 POLR1B RNA polymerase I subunit B 2 4
MIRT506372 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT506451 NACC2 NACC family member 2 2 4
MIRT506673 LZIC leucine zipper and CTNNBIP1 domain containing 2 4
MIRT506834 KIF23 kinesin family member 23 2 4
MIRT506880 KIAA0101 PCNA clamp associated factor 2 6
MIRT507359 FAM129A family with sequence similarity 129 member A 2 6
MIRT507957 BNIP2 BCL2 interacting protein 2 2 6
MIRT509433 MCM7 minichromosome maintenance complex component 7 2 6
MIRT510872 RAN RAN, member RAS oncogene family 2 8
MIRT511078 NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 2 4
MIRT511254 KLHL36 kelch like family member 36 2 6
MIRT513699 RBM20 RNA binding motif protein 20 2 4
MIRT513742 PKNOX1 PBX/knotted 1 homeobox 1 2 2
MIRT513981 CEP97 centrosomal protein 97 2 2
MIRT514092 EPS15L1 epidermal growth factor receptor pathway substrate 15 like 1 2 6
MIRT515928 MFAP2 microfibril associated protein 2 2 4
MIRT519574 ZNFX1 zinc finger NFX1-type containing 1 2 4
MIRT521297 RRAGD Ras related GTP binding D 2 4
MIRT521348 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT521693 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 8
MIRT521778 PPIG peptidylprolyl isomerase G 2 8
MIRT522191 NR2C2 nuclear receptor subfamily 2 group C member 2 2 6
MIRT524696 BTG3 BTG anti-proliferation factor 3 2 8
MIRT525663 NHSL2 NHS like 2 2 2
MIRT527252 TMEM196 transmembrane protein 196 2 2
MIRT527466 CLEC12B C-type lectin domain family 12 member B 2 2
MIRT529535 ICMT isoprenylcysteine carboxyl methyltransferase 2 2
MIRT530146 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2 2
MIRT530851 RAG1 recombination activating 1 2 4
MIRT531109 PEX13 peroxisomal biogenesis factor 13 2 2
MIRT534263 SLC12A7 solute carrier family 12 member 7 2 2
MIRT534756 RASGEF1A RasGEF domain family member 1A 2 2
MIRT535175 PLEKHB2 pleckstrin homology domain containing B2 2 2
MIRT535246 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 4
MIRT535401 PER1 period circadian clock 1 2 2
MIRT536036 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT536347 LEFTY1 left-right determination factor 1 2 2
MIRT536413 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT536437 KMT2B lysine methyltransferase 2B 2 6
MIRT536604 IRF2 interferon regulatory factor 2 2 2
MIRT536642 INO80D INO80 complex subunit D 2 2
MIRT536860 HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2 2
MIRT537241 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2 2
MIRT537728 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT537988 DPP8 dipeptidyl peptidase 8 2 2
MIRT538037 DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 2 2
MIRT538255 CUL3 cullin 3 2 4
MIRT538525 CLCN3 chloride voltage-gated channel 3 2 2
MIRT538659 CCSAP centriole, cilia and spindle associated protein 2 2
MIRT538779 C7orf60 base methyltransferase of 25S rRNA 2 homolog 2 4
MIRT538849 BTG1 BTG anti-proliferation factor 1 2 2
MIRT538923 BRI3BP BRI3 binding protein 2 6
MIRT539114 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT539454 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT541085 RLIM ring finger protein, LIM domain interacting 2 2
MIRT543117 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT543181 FICD FIC domain containing 2 2
MIRT543575 RPF2 ribosome production factor 2 homolog 2 4
MIRT544113 IPMK inositol polyphosphate multikinase 2 2
MIRT544625 CSDE1 cold shock domain containing E1 2 2
MIRT544699 ZNF224 zinc finger protein 224 2 4
MIRT544992 MFF mitochondrial fission factor 2 4
MIRT546248 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT546282 TMEM30A transmembrane protein 30A 2 4
MIRT546290 TMEM200C transmembrane protein 200C 2 4
MIRT546558 SATB2 SATB homeobox 2 2 2
MIRT546815 RAP2C RAP2C, member of RAS oncogene family 2 2
MIRT547046 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT547474 MBNL3 muscleblind like splicing regulator 3 2 4
MIRT547761 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT547892 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT548315 EPHA4 EPH receptor A4 2 2
MIRT548383 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 4
MIRT548460 EGLN3 egl-9 family hypoxia inducible factor 3 2 2
MIRT548579 DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 2 2
MIRT548858 CERCAM cerebral endothelial cell adhesion molecule 2 2
MIRT548896 CHEK2 checkpoint kinase 2 2 4
MIRT549319 ARHGAP12 Rho GTPase activating protein 12 2 4
MIRT550302 ZNF681 zinc finger protein 681 2 2
MIRT551120 ZNF107 zinc finger protein 107 2 2
MIRT551406 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT552173 DAD1 defender against cell death 1 2 2
MIRT552856 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT552892 WASL Wiskott-Aldrich syndrome like 2 4
MIRT553075 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT553668 TFAP4 transcription factor AP-4 2 4
MIRT553700 TCF7L2 transcription factor 7 like 2 2 2
MIRT554608 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT554860 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT556157 MECP2 methyl-CpG binding protein 2 2 2
MIRT556179 MCC mutated in colorectal cancers 2 2
MIRT556529 LIN52 lin-52 DREAM MuvB core complex component 2 2
MIRT556723 KLHL21 kelch like family member 21 2 4
MIRT557054 HOXB3 homeobox B3 2 2
MIRT557587 GNPTAB N-acetylglucosamine-1-phosphate transferase alpha and beta subunits 2 2
MIRT557661 GATA6 GATA binding protein 6 2 2
MIRT557753 FRS2 fibroblast growth factor receptor substrate 2 2 2
MIRT557881 FEM1B fem-1 homolog B 2 4
MIRT558215 EFCAB14 EF-hand calcium binding domain 14 2 4
MIRT558264 DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 2 2
MIRT558327 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT558766 CFL2 cofilin 2 2 2
MIRT561037 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT561324 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT561641 RUNX3 runt related transcription factor 3 2 2
MIRT562555 CCDC71L coiled-coil domain containing 71 like 2 4
MIRT562961 LRPAP1 LDL receptor related protein associated protein 1 2 2
MIRT564680 ZNF35 zinc finger protein 35 2 2
MIRT565694 SESN3 sestrin 3 2 2
MIRT565910 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT566141 RACGAP1 Rac GTPase activating protein 1 2 2
MIRT567047 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT567076 KBTBD2 kelch repeat and BTB domain containing 2 2 2
MIRT567539 FGFR1OP FGFR1 oncogene partner 2 2
MIRT567624 FAM210A family with sequence similarity 210 member A 2 2
MIRT570321 ZNF70 zinc finger protein 70 2 2
MIRT571759 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT571857 NKIRAS1 NFKB inhibitor interacting Ras like 1 2 2
MIRT573372 LIMA1 LIM domain and actin binding 1 2 2
MIRT574561 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT614729 ATAT1 alpha tubulin acetyltransferase 1 2 4
MIRT617877 ESR1 estrogen receptor 1 2 2
MIRT624421 CBX8 chromobox 8 2 2
MIRT625865 SLC35C2 solute carrier family 35 member C2 2 2
MIRT630703 DICER1 dicer 1, ribonuclease III 2 4
MIRT632514 PTPN9 protein tyrosine phosphatase, non-receptor type 9 2 2
MIRT641797 USP32 ubiquitin specific peptidase 32 2 2
MIRT663625 SEC23B Sec23 homolog B, coat complex II component 2 2
MIRT680135 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT702388 KLF10 Kruppel like factor 10 2 2
MIRT707830 TMEM133 transmembrane protein 133 2 2
MIRT708885 MOCS2 molybdenum cofactor synthesis 2 2 2
MIRT709122 C3orf18 chromosome 3 open reading frame 18 2 2
MIRT709635 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT710596 CDCA4 cell division cycle associated 4 2 2
MIRT710802 IFNLR1 interferon lambda receptor 1 2 2
MIRT711782 RFXAP regulatory factor X associated protein 2 2
MIRT713344 KLRD1 killer cell lectin like receptor D1 2 2
MIRT713640 MED8 mediator complex subunit 8 2 2
MIRT713916 IGF2R insulin like growth factor 2 receptor 2 2
MIRT715068 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715206 FKTN fukutin 2 2
MIRT717819 FAM114A1 family with sequence similarity 114 member A1 2 2
MIRT720543 CHERP calcium homeostasis endoplasmic reticulum protein 2 2
MIRT720636 ELF5 E74 like ETS transcription factor 5 2 2
MIRT721703 ISY1 ISY1 splicing factor homolog 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-519c Bilobalide NULL 73581 Quantitative real-time PCR Human breast cancer MCF-7 cells 21796641 2011 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-519c Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-519c-3p Mitoxantrone 4212 NSC279836 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-519c-3p Cisplatin 5460033 NSC119875 approved resistant High Germ Cell Tumor cell line (NTERA-2)
hsa-miR-519c-3p Vinorelbine 44424639 approved resistant High Non-Small Cell Lung Cancer cell line (H358, H1993)
hsa-miR-519c-3p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-519c-3p Gemcitabine 60750 NSC613327 approved sensitive Low Pancreatic Cancer cell line (MIA-PaCa-2)
hsa-miR-519c-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-519c-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-519c-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-519c-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-519c-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-519c-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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