miRTarBase - #MIRT000534


—
pre-miRNA Information
pre-miRNA hsa-mir-216a   
Genomic Coordinates chr2: 55988950 - 55989059
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 15 2 - 55989027 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757094946 2 dbSNP
rs746980700 8 dbSNP
rs1249388997 12 dbSNP
rs1188616124 15 dbSNP
rs1490501989 19 dbSNP
rs1465789697 20 dbSNP
rs370221981 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Tissue .
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol PTEN   
Synonyms 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, PTENbeta, TEP1
Description phosphatase and tensin homolog
Transcript NM_000314   
Expression
Putative miRNA Targets on PTEN
3'UTR of PTEN
(miRNA target sites are highlighted)		 
>PTEN|NM_000314|3'UTR
   1 ATTTTTTTTTATCAAGAGGGATAAAACACCATGAAAATAAACTTGAATAAACTGAAAATGGACCTTTTTTTTTTTAATGG
  81 CAATAGGACATTGTGTCAGATTACCAGTTATAGGAACAATTCTCTTTTCCTGACCAATCTTGTTTTACCCTATACATCCA
 161 CAGGGTTTTGACACTTGTTGTCCAGTTGAAAAAAGGTTGTGTAGCTGTGTCATGTATATACCTTTTTGTGTCAAAAGGAC
 241 ATTTAAAATTCAATTAGGATTAATAAAGATGGCACTTTCCCGTTTTATTCCAGTTTTATAAAAAGTGGAGACAGACTGAT
 321 GTGTATACGTAGGAATTTTTTCCTTTTGTGTTCTGTCACCAACTGAAGTGGCTAAAGAGCTTTGTGATATACTGGTTCAC
 401 ATCCTACCCCTTTGCACTTGTGGCAACAGATAAGTTTGCAGTTGGCTAAGAGAGGTTTCCGAAGGGTTTTGCTACATTCT
 481 AATGCATGTATTCGGGTTAGGGGAATGGAGGGAATGCTCAGAAAGGAAATAATTTTATGCTGGACTCTGGACCATATACC
 561 ATCTCCAGCTATTTACACACACCTTTCTTTAGCATGCTACAGTTATTAATCTGGACATTCGAGGAATTGGCCGCTGTCAC
 641 TGCTTGTTGTTTGCGCATTTTTTTTTAAAGCATATTGGTGCTAGAAAAGGCAGCTAAAGGAAGTGAATCTGTATTGGGGT
 721 ACAGGAATGAACCTTCTGCAACATCTTAAGATCCACAAATGAAGGGATATAAAAATAATGTCATAGGTAAGAAACACAGC
 801 AACAATGACTTAACCATATAAATGTGGAGGCTATCAACAAAGAATGGGCTTGAAACATTATAAAAATTGACAATGATTTA
 881 TTAAATATGTTTTCTCAATTGTAACGACTTCTCCATCTCCTGTGTAATCAAGGCCAGTGCTAAAATTCAGATGCTGTTAG
 961 TACCTACATCAGTCAACAACTTACACTTATTTTACTAGTTTTCAATCATAATACCTGCTGTGGATGCTTCATGTGCTGCC
1041 TGCAAGCTTCTTTTTTCTCATTAAATATAAAATATTTTGTAATGCTGCACAGAAATTTTCAATTTGAGATTCTACAGTAA
1121 GCGTTTTTTTTCTTTGAAGATTTATGATGCACTTATTCAATAGCTGTCAGCCGTTCCACCCTTTTGACCTTACACATTCT
1201 ATTACAATGAATTTTGCAGTTTTGCACATTTTTTAAATGTCATTAACTGTTAGGGAATTTTACTTGAATACTGAATACAT
1281 ATAATGTTTATATTAAAAAGGACATTTGTGTTAAAAAGGAAATTAGAGTTGCAGTAAACTTTCAATGCTGCACACAAAAA
1361 AAAGACATTTGATTTTTCAGTAGAAATTGTCCTACATGTGCTTTATTGATTTGCTATTGAAAGAATAGGGTTTTTTTTTT
1441 TTTTTTTTTTTTTTTTTTTAAATGTGCAGTGTTGAATCATTTCTTCATAGTGCTCCCCCGAGTTGGGACTAGGGCTTCAA
1521 TTTCACTTCTTAAAAAAAATCATCATATATTTGATATGCCCAGACTGCATACGATTTTAAGCGGAGTACAACTACTATTG
1601 TAAAGCTAATGTGAAGATATTATTAAAAAGGTTTTTTTTTCCAGAAATTTGGTGTCTTCAAATTATACCTTCACCTTGAC
1681 ATTTGAATATCCAGCCATTTTGTTTCTTAATGGTATAAAATTCCATTTTCAATAACTTATTGGTGCTGAAATTGTTCACT
1761 AGCTGTGGTCTGACCTAGTTAATTTACAAATACAGATTGAATAGGACCTACTAGAGCAGCATTTATAGAGTTTGATGGCA
1841 AATAGATTAGGCAGAACTTCATCTAAAATATTCTTAGTAAATAATGTTGACACGTTTTCCATACCTTGTCAGTTTCATTC
1921 AACAATTTTTAAATTTTTAACAAAGCTCTTAGGATTTACACATTTATATTTAAACATTGATATATAGAGTATTGATTGAT
2001 TGCTCATAAGTTAAATTGGTAAAGTTAGAGACAACTATTCTAACACCTCACCATTGAAATTTATATGCCACCTTGTCTTT
2081 CATAAAAGCTGAAAATTGTTACCTAAAATGAAAATCAACTTCATGTTTTGAAGATAGTTATAAATATTGTTCTTTGTTAC
2161 AATTTCGGGCACCGCATATTAAAACGTAACTTTATTGTTCCAATATGTAACATGGAGGGCCAGGTCATAAATAATGACAT
2241 TATAATGGGCTTTTGCACTGTTATTATTTTTCCTTTGGAATGTGAAGGTCTGAATGAGGGTTTTGATTTTGAATGTTTCA
2321 ATGTTTTTGAGAAGCCTTGCTTACATTTTATGGTGTAGTCATTGGAAATGGAAAAATGGCATTATATATATTATATATAT
2401 AAATATATATTATACATACTCTCCTTACTTTATTTCAGTTACCATCCCCATAGAATTTGACAAGAATTGCTATGACTGAA
2481 AGGTTTTCGAGTCCTAATTAAAACTTTATTTATGGCAGTATTCATAATTAGCCTGAAATGCATTCTGTAGGTAATCTCTG
2561 AGTTTCTGGAATATTTTCTTAGACTTTTTGGATGTGCAGCAGCTTACATGTCTGAAGTTACTTGAAGGCATCACTTTTAA
2641 GAAAGCTTACAGTTGGGCCCTGTACCATCCCAAGTCCTTTGTAGCTCCTCTTGAACATGTTTGCCATACTTTTAAAAGGG
2721 TAGTTGAATAAATAGCATCACCATTCTTTGCTGTGGCACAGGTTATAAACTTAAGTGGAGTTTACCGGCAGCATCAAATG
2801 TTTCAGCTTTAAAAAATAAAAGTAGGGTACAAGTTTAATGTTTAGTTCTAGAAATTTTGTGCAATATGTTCATAACGATG
2881 GCTGTGGTTGCCACAAAGTGCCTCGTTTACCTTTAAATACTGTTAATGTGTCATGCATGCAGATGGAAGGGGTGGAACTG
2961 TGCACTAAAGTGGGGGCTTTAACTGTAGTATTTGGCAGAGTTGCCTTCTACCTGCCAGTTCAAAAGTTCAACCTGTTTTC
3041 ATATAGAATATATATACTAAAAAATTTCAGTCTGTTAAACAGCCTTACTCTGATTCAGCCTCTTCAGATACTCTTGTGCT
3121 GTGCAGCAGTGGCTCTGTGTGTAAATGCTATGCACTGAGGATACACAAAAATACCAATATGATGTGTACAGGATAATGCC
3201 TCATCCCAATCAGATGTCCATTTGTTATTGTGTTTGTTAACAACCCTTTATCTCTTAGTGTTATAAACTCCACTTAAAAC
3281 TGATTAAAGTCTCATTCTTGTCATTGTGTGGGTGTTTTATTAAATGAGAGTTTATAATTCAAATTGCTTAAGTCCATTGA
3361 AGTTTTAATTAATGGGCAGCCAAATGTGAATACAAAGTTTTCAGTTTTTTTTTTTCCTGCTGTCCTTCAAAGCCTACTGT
3441 TTAAAAAAAAAAAAAAAAAAAAACATGGCCTGAGAGTAGAGTATCTGTCTACTCATGTTTAATTAAGGAAAAACACTTAT
3521 TTTTAGGGCTTTAGTCATCACTTCATAAATTGTATAAGCACATTAAATAGCGTTCTAGTCCTGAAAAAGTCCAAGATTCT
3601 TAGAAAATTGTGCATATTTTTATTATGACAGATGTTTGAAGATAATTCCCCAGAATGGATTTGATACTTTAGATTTCAAT
3681 TTTGTGGCTTTTGTCTATTATTCTGTACTCTGCCATCAGCATATGGAAAGCTTCATTTACTCATCATGACTTGTGCCATA
3761 TAAAAATTGATATTTCGGAATAGTCTAAAGGACTTTTTGTACTTGAATTTAATCATGTTGTTTCTAATATTCTTAAAAGC
3841 TTGAAGACTAAAGCATATCCTTTCAACAAAGCATAGTAAGGTAATAAGAAAGTGTAGTTTGTACAAGTGTTAAAAAAATA
3921 AAGTAGACAATGTTACAGTGGGACTTATTATTTCAAGTTTACATTTTCTCCATGTAATTTTTTAAAAAGTAAATGAAAAA
4001 ATGTGCAATAATGTAAAATATGAAGTGTATGTGTACACACATTTTATTTTTCGGTATCTTGGGTATACGTATGGTTGAAA
4081 ACTATACTGGAGTCTAAAAGTATTCTAATTTATAAGAAGACATTTTGGTGATGTTTGAAAAATAGAAATGTGCTAGTTTT
4161 GTTTTTATATCATGTCCTTTGTACGTTGTAATATGAGCTGGCTTGGTTCAGTAAATGCCATCACCATTTCCATTGAGAAT
4241 TTAAAACTCACCAGTGTTTAATATGCAGGCTTCCAAAGGCTTATGAAAAAAATCAAGACCCTTAAATCTAGTTAATTTGC
4321 TGCTAACATGAAACTCTTTGGTTCTTTTATTTTTGCCAGATAATTAGACACACATCTAAAGCTTAGTCTTAAATGGCTTA
4401 AGTGTAGCTATTGATTAGTGCTGTTGCTAGTTCAGAAAGAAATGTTTGTGAATGGAAACAAGAATATTCAGTCCAAACTG
4481 TTGTAAGGACAGTACCTGAAAACCAGGAAACAGGATAATGGAAAAAGTCTTTTAAAGATGAAATGTTGGAGCCAACTTTC
4561 TTATAGAATTAATTGTATGTGGCTATAGAAAGCCTAATGATTGTTGCTTATTTTTGAGAGCATATTATTCTTTTATGACC
4641 ATAATCTTGCTGTTTTTCCATCTTCCAAAAGATCTTCCTTCTAATATGTATATCAGAATGTGGGTAGCCAGTCAGACAAA
4721 TTCATATTGGTTGGTAGCTTTAAAAAGTTTGTAATGTGAAGACAGGAAAGGACAAAATAGTTTGCTTTGGTGGTAGTACT
4801 CTGGTTGTTAAGCTAGGTATTTTGAGACTACTTCCCCATCACAACAACAATAAAATAATCACTCATAATCCTATCACCTG
4881 GAGACATAGCCATCGTTAATATGTTAGTGACTATACAATCATGTTTTCTTCTGTATATCCATGTATATTCTTTAAAAATG
4961 AAATTTATACTGTACCTGATCTCAAAGCTTTTTAGCTTAGTATATCTGTCATGAATTTGTAGGATGTTCCATTGCATCAG
5041 AAAACGGACAGTGATTTGATTACTTTCTAATGCCACAGATGCAGATTACATGTAGTTATTGAGAATCCTTTCGAATTCAG
5121 TGGCTTAATCATGAATGTCTAAATATTGTTGACATTAGGATGATACATGTAAATTAAAGTTACATTTGTTTAGCATAGAC
5201 AAGCTTAACATTGTAGATGTTTCTCTTCAAAAATCATCTTAAACATTTGCATTTGGAATTGTGTTAAATAGAATGTGTGA
5281 AACACTGTATTAGTAAACTTCATCACCTTTCTACTTCCTTATAGTTTGAACTTTTCAGTTTTTGTAGTTCCCAAACAGTT
5361 GCTCAATTTAGAGCAAATTAATTTAACACCTGCCAAAAAAAGGCTGCTGTTGGCTTATCAGTTGTCTTTAAATTCAAATG
5441 CTCATGTGACTTTTATCACATCAAAAAATATTTCATTAATGATTCACCTTTAGCTCTGAAAATTACCGCGTTTAGTAATT
5521 ATAGTGGGCTTATAAAAACATGCAACTCTTTTTGATAGTTATTTGAGAATTTTGGTGAAAAATATTTAGCTGAGGGCAGT
5601 ATAGAACTTATAAACCAATATATTGATATTTTTAAAACATTTTTACATATAAGTAAACTGCCATCTTTGAGCATAACTAC
5681 ATTTAAAAATAAAGCTGCATATTTTTAAATCAAGTGTTTAACAAGAATTTATATTTTTTATTTTTTAAAATTAAAAATAA
5761 TTTATATTTCCTCTGTTGCATGAGGATTCTCATCTGTGCTTATAATGGTTAGAGATTTTATTTGTGTGGAATGAAGTGAG
5841 GCTTGTAGTCATGGTTCTAGTGTTTCAGTTTGCCAAGTCTGTTTACTGCAGTGAAATTCATCAAATGTTTCAGTGTGGTT
5921 TTCTGTAGCCTATCATTTACTGGCTATTTTTTTATGTACACCTTTAGGATTTTCTGCCTACTCTATCCAGTTGTCCAAAT
6001 GATATCCTACATTTTACAAATGCCCTTTCAGTTTCTATTTTCTTTTTCCATTAAATTGCCCTCATGTCCTAATGTGCAGT
6081 TTGTAAGTGTGTGTGTGTGTGTCTGTGTGTGTGTGAATTTGATTTTCAAGAGTGCTAGACTTCCAATTTGAGAGATTAAA
6161 TAATTTAATTCAGGCAAACATTTTTCATTGGAATTTCACAGTTCATTGTAATGAAAATGTTAATCCTGGATGACCTTTGA
6241 CATACAGTAATGAATCTTGGATATTAATGAATTTGTTAGTAGCATCTTGATGTGTGTTTTAATGAGTTATTTTCAAAGTT
6321 GTGCATTAAACCAAAGTTGGCATACTGGAAGTGTTTATATCAAGTTCCATTTGGCTACTGATGGACAAAAAATAGAAATG
6401 CCTTCCTATGGAGAGTATTTTTCCTTTAAAAAATTAAAAAGGTTAATTATTTTGACTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agUGUC----AACGGUCGACUCUAAu 5'
            ||||    || | | :||||||| 
Target 5' gcACAGAAATTTTCAATTTGAGATTc 3'
 1087 - 1112 158.00 -12.80
2 
miRNA  3' agUGUCAACGGUCGACUCUAAu 5'
            ||  || ||| :||||| | 
Target 5' tcACCATTTCCA-TTGAGAATt 3'
 4221 - 4241 127.00 -11.32
3 
miRNA  3' agUGU-CAACGGUCGACUCUAAu 5'
            ||| || |::| :||||| | 
Target 5' ttACATGTAGTTA-TTGAGAATc 3'
 5086 - 5107 127.00 -9.72
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
234144 1 ClinVar
428265 1 ClinVar
449272 1 ClinVar
189424 2 ClinVar
548800 2 ClinVar
629835 2 ClinVar
492309 4 ClinVar
419119 6 ClinVar
421205 7 ClinVar
420786 8 ClinVar
167551 9 ClinVar
495803 11 ClinVar
923543 18 ClinVar
629027 21 ClinVar
877732 28 ClinVar
237636 65 ClinVar
301424 75 ClinVar
877733 76 ClinVar
492735 79 ClinVar
301425 125 ClinVar
301426 175 ClinVar
301427 179 ClinVar
1191461 217 ClinVar
301428 283 ClinVar
301429 354 ClinVar
301430 422 ClinVar
301431 431 ClinVar
301432 516 ClinVar
301433 598 ClinVar
301434 602 ClinVar
301435 622 ClinVar
301436 632 ClinVar
301437 641 ClinVar
301438 658 ClinVar
301439 668 ClinVar
301440 789 ClinVar
301441 789 ClinVar
301442 791 ClinVar
878766 971 ClinVar
879353 1029 ClinVar
301443 1035 ClinVar
301444 1120 ClinVar
301445 1124 ClinVar
301446 1151 ClinVar
879354 1153 ClinVar
301447 1174 ClinVar
301448 1203 ClinVar
301449 1238 ClinVar
879355 1283 ClinVar
301450 1356 ClinVar
301451 1431 ClinVar
301452 1431 ClinVar
301453 1431 ClinVar
301454 1431 ClinVar
879719 1431 ClinVar
301455 1435 ClinVar
301456 1441 ClinVar
301457 1443 ClinVar
301458 1450 ClinVar
301459 1460 ClinVar
301460 1460 ClinVar
301461 1461 ClinVar
301462 1500 ClinVar
879720 1502 ClinVar
301463 1517 ClinVar
301464 1530 ClinVar
301465 1566 ClinVar
301466 1573 ClinVar
301467 1577 ClinVar
301468 1584 ClinVar
301469 1592 ClinVar
301470 1621 ClinVar
301471 1670 ClinVar
877771 1696 ClinVar
301472 1703 ClinVar
878810 1741 ClinVar
301473 1746 ClinVar
301474 1763 ClinVar
878811 1834 ClinVar
301475 1946 ClinVar
301476 1955 ClinVar
301477 1956 ClinVar
878812 2007 ClinVar
301478 2028 ClinVar
301479 2062 ClinVar
879394 2073 ClinVar
301480 2111 ClinVar
301481 2163 ClinVar
301482 2174 ClinVar
301483 2186 ClinVar
301484 2201 ClinVar
301485 2204 ClinVar
301486 2205 ClinVar
301487 2261 ClinVar
879395 2282 ClinVar
301488 2404 ClinVar
301489 2416 ClinVar
301490 2438 ClinVar
301491 2552 ClinVar
301492 2559 ClinVar
879776 2650 ClinVar
301493 2683 ClinVar
301494 2685 ClinVar
301495 2747 ClinVar
301496 2772 ClinVar
879777 2787 ClinVar
301497 2790 ClinVar
301498 2822 ClinVar
301499 2906 ClinVar
301500 3034 ClinVar
879778 3062 ClinVar
301501 3084 ClinVar
301502 3178 ClinVar
802614 3443 ClinVar
802615 3443 ClinVar
COSN30572838 11 COSMIC
COSN15839116 13 COSMIC
COSN7073906 23 COSMIC
COSN30515415 35 COSMIC
COSN31523653 42 COSMIC
COSN30526723 48 COSMIC
COSN18734283 76 COSMIC
COSN30510112 115 COSMIC
COSN26538324 210 COSMIC
COSN31544839 282 COSMIC
COSN15337398 302 COSMIC
COSN31480740 378 COSMIC
COSN31484189 453 COSMIC
COSN7073907 489 COSMIC
COSN31606779 536 COSMIC
COSN26578169 578 COSMIC
COSN31486740 588 COSMIC
COSN29467765 668 COSMIC
COSN30538306 694 COSMIC
COSN32129172 701 COSMIC
COSN30159574 899 COSMIC
COSN31526499 1150 COSMIC
COSN21828072 1190 COSMIC
COSN19658832 1208 COSMIC
COSN19032527 1211 COSMIC
COSN19658833 1218 COSMIC
COSN31596758 1283 COSMIC
COSN5888087 1304 COSMIC
COSN1505629 1324 COSMIC
COSN31541765 1364 COSMIC
COSN31588099 1461 COSMIC
COSN16805777 1499 COSMIC
COSN31549727 1500 COSMIC
COSN8310093 1517 COSMIC
COSN31535917 1572 COSMIC
COSN30174031 1617 COSMIC
COSN31529619 1632 COSMIC
COSN27483832 1641 COSMIC
COSN30175766 1642 COSMIC
COSN31597308 1670 COSMIC
COSN15228422 1717 COSMIC
COSN8640612 1774 COSMIC
COSN24575665 1784 COSMIC
COSN2486344 1790 COSMIC
COSN24940573 1842 COSMIC
COSN31485329 1988 COSMIC
COSN30158037 2117 COSMIC
COSN31481331 2123 COSMIC
COSN31769566 2123 COSMIC
COSN31571826 2167 COSMIC
COSN31584232 2175 COSMIC
COSN28802473 2186 COSMIC
COSN31769567 2252 COSMIC
COSN31485336 2291 COSMIC
COSN31527543 2325 COSMIC
COSN31769568 2398 COSMIC
COSN31555504 2402 COSMIC
COSN31487418 2805 COSMIC
COSN5292933 2823 COSMIC
COSN31585113 2858 COSMIC
COSN31591445 2877 COSMIC
COSN31561621 2964 COSMIC
COSN26576833 3093 COSMIC
COSN8640613 3203 COSMIC
COSN28834362 3363 COSMIC
COSN23747551 3416 COSMIC
COSN29006641 3416 COSMIC
COSN23732659 3464 COSMIC
COSN23832830 3464 COSMIC
COSN29226380 3504 COSMIC
COSN27143817 3889 COSMIC
COSN5292934 4000 COSMIC
COSN31769569 4064 COSMIC
COSN1505630 4242 COSMIC
COSN15621864 4426 COSMIC
COSN5292935 4439 COSMIC
COSN28201559 4778 COSMIC
COSN20860896 4888 COSMIC
COSN31769570 6086 COSMIC
COSN27992657 6102 COSMIC
COSN7073910 6104 COSMIC
COSN14843256 6106 COSMIC
rs701848 1517 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs876660879 1 dbSNP
rs1359705871 2 dbSNP
rs1452888068 2 dbSNP
rs756681683 2 dbSNP
rs786204876 2 dbSNP
rs1206556168 3 dbSNP
rs1006891299 6 dbSNP
rs1064794975 7 dbSNP
rs1064794700 8 dbSNP
rs727504115 9 dbSNP
rs748082411 10 dbSNP
rs769236743 11 dbSNP
rs1259242831 14 dbSNP
rs777252107 24 dbSNP
rs1180734248 27 dbSNP
rs748897412 28 dbSNP
rs770460423 30 dbSNP
rs774105075 38 dbSNP
rs760901642 39 dbSNP
rs368984469 49 dbSNP
rs769098710 52 dbSNP
rs1478629664 65 dbSNP
rs878853930 65 dbSNP
rs879062370 65 dbSNP
rs1044487 66 dbSNP
rs1185433220 68 dbSNP
rs1025744243 69 dbSNP
rs886047398 75 dbSNP
rs74535369 76 dbSNP
rs74489567 78 dbSNP
rs1445153364 81 dbSNP
rs537081967 84 dbSNP
rs1373393548 88 dbSNP
rs1477836829 90 dbSNP
rs578049537 98 dbSNP
rs1259182445 100 dbSNP
rs1014281064 103 dbSNP
rs1025215023 104 dbSNP
rs971508789 107 dbSNP
rs1396700853 111 dbSNP
rs1174615566 118 dbSNP
rs1431681317 120 dbSNP
rs774400345 121 dbSNP
rs1470384433 123 dbSNP
rs886047399 125 dbSNP
rs979723936 136 dbSNP
rs927044101 138 dbSNP
rs1229296257 158 dbSNP
rs1158509719 162 dbSNP
rs1383438932 167 dbSNP
rs957087702 173 dbSNP
rs989882441 174 dbSNP
rs1371013115 175 dbSNP
rs886047400 175 dbSNP
rs913087410 175 dbSNP
rs945893570 178 dbSNP
rs886047401 179 dbSNP
rs1180618495 184 dbSNP
rs912443381 186 dbSNP
rs1239099940 199 dbSNP
rs1319429514 201 dbSNP
rs1330930148 205 dbSNP
rs942712055 214 dbSNP
rs558365328 217 dbSNP
rs3895069 226 dbSNP
rs1325238881 254 dbSNP
rs1323581799 258 dbSNP
rs898602522 267 dbSNP
rs1259570199 282 dbSNP
rs576872432 283 dbSNP
rs1047129845 287 dbSNP
rs1394125934 289 dbSNP
rs1297217962 290 dbSNP
rs1458154490 300 dbSNP
rs1369680383 311 dbSNP
rs3895070 321 dbSNP
rs887305867 322 dbSNP
rs1013748775 327 dbSNP
rs1025649027 329 dbSNP
rs1436403337 329 dbSNP
rs868477060 330 dbSNP
rs1490138272 331 dbSNP
rs1210651502 335 dbSNP
rs545229150 336 dbSNP
rs1263685149 338 dbSNP
rs181234898 354 dbSNP
rs3184264 356 dbSNP
rs921525366 360 dbSNP
rs1309859556 361 dbSNP
rs1242277619 374 dbSNP
rs1333762969 375 dbSNP
rs1306095206 378 dbSNP
rs746867863 391 dbSNP
rs1386924290 401 dbSNP
rs1392471035 403 dbSNP
rs957015245 408 dbSNP
rs1362099471 416 dbSNP
rs1455385884 417 dbSNP
rs989933138 418 dbSNP
rs1020030726 421 dbSNP
rs141648241 422 dbSNP
rs1390631142 426 dbSNP
rs1423207931 430 dbSNP
rs886047402 431 dbSNP
rs376860960 435 dbSNP
rs1267061199 441 dbSNP
rs1347021539 446 dbSNP
rs1222086148 449 dbSNP
rs1488639331 459 dbSNP
rs1288332229 462 dbSNP
rs2673835 465 dbSNP
rs1405126177 466 dbSNP
rs541039409 476 dbSNP
rs912481857 482 dbSNP
rs942595930 487 dbSNP
rs1333519811 494 dbSNP
rs560599448 495 dbSNP
rs1404026253 496 dbSNP
rs1044492 504 dbSNP
rs1240533263 506 dbSNP
rs886047403 516 dbSNP
rs1261297397 529 dbSNP
rs1358632586 532 dbSNP
rs1384905576 541 dbSNP
rs1173469887 545 dbSNP
rs774674775 548 dbSNP
rs975282007 550 dbSNP
rs1427686069 553 dbSNP
rs561279008 554 dbSNP
rs1478304049 562 dbSNP
rs1219976584 564 dbSNP
rs919955560 577 dbSNP
rs1191158838 584 dbSNP
rs531589996 588 dbSNP
rs183510626 591 dbSNP
rs886047404 598 dbSNP
rs1248661934 600 dbSNP
rs1261088978 601 dbSNP
rs371547288 602 dbSNP
rs1182615857 604 dbSNP
rs532648593 607 dbSNP
rs1318169184 611 dbSNP
rs1279490742 613 dbSNP
rs761682131 620 dbSNP
rs1428061611 621 dbSNP
rs886047405 622 dbSNP
rs1335409039 625 dbSNP
rs1385166625 626 dbSNP
rs1443260602 627 dbSNP
rs949588940 628 dbSNP
rs886047406 632 dbSNP
rs1165885891 633 dbSNP
rs1046537432 634 dbSNP
rs530317615 635 dbSNP
rs770650569 638 dbSNP
rs886047407 641 dbSNP
rs1002487820 644 dbSNP
rs776368591 647 dbSNP
rs1188151534 651 dbSNP
rs547244072 652 dbSNP
rs540531969 655 dbSNP
rs756513970 656 dbSNP
rs1202837604 657 dbSNP
rs1020462408 658 dbSNP
rs1212480494 658 dbSNP
rs543873570 658 dbSNP
rs886047408 658 dbSNP
rs1392690555 662 dbSNP
rs967126971 667 dbSNP
rs886047409 668 dbSNP
rs1247548808 675 dbSNP
rs1381978139 679 dbSNP
rs1243632735 692 dbSNP
rs987055438 693 dbSNP
rs769858445 694 dbSNP
rs1336429227 704 dbSNP
rs1359952914 704 dbSNP
rs1203542693 707 dbSNP
rs1249902622 712 dbSNP
rs878988941 714 dbSNP
rs1019465806 715 dbSNP
rs963833029 720 dbSNP
rs975335648 723 dbSNP
rs1446322059 724 dbSNP
rs919838963 726 dbSNP
rs1433571591 733 dbSNP
rs1440045433 734 dbSNP
rs1234464802 753 dbSNP
rs1201991574 767 dbSNP
rs1242558620 774 dbSNP
rs1443359397 780 dbSNP
rs138309082 789 dbSNP
rs886047410 789 dbSNP
rs982768164 789 dbSNP
rs908631358 790 dbSNP
rs886047411 791 dbSNP
rs1375965264 802 dbSNP
rs1278158450 806 dbSNP
rs1186006767 809 dbSNP
rs1386381235 817 dbSNP
rs1428349350 819 dbSNP
rs1350713170 823 dbSNP
rs1325547661 829 dbSNP
rs1422801844 834 dbSNP
rs529945687 840 dbSNP
rs548492439 851 dbSNP
rs570010681 857 dbSNP
rs949521415 857 dbSNP
rs759474309 861 dbSNP
rs536995550 863 dbSNP
rs1440305289 868 dbSNP
rs1046907198 874 dbSNP
rs1370986161 879 dbSNP
rs1175272987 882 dbSNP
rs1469273577 885 dbSNP
rs1246905370 889 dbSNP
rs1463143961 890 dbSNP
rs926814444 899 dbSNP
rs749778496 903 dbSNP
rs1054044001 906 dbSNP
rs765100893 912 dbSNP
rs932933780 915 dbSNP
rs1256042530 916 dbSNP
rs1331482309 917 dbSNP
rs1217913921 924 dbSNP
rs558530548 930 dbSNP
rs1319253545 936 dbSNP
rs894030109 940 dbSNP
rs570416975 942 dbSNP
rs1223597962 947 dbSNP
rs1368811926 953 dbSNP
rs869131141 955 dbSNP
rs2735347 958 dbSNP
rs1404776755 967 dbSNP
rs773513402 971 dbSNP
rs532759542 975 dbSNP
rs902828907 977 dbSNP
rs1338688192 991 dbSNP
rs1008006197 998 dbSNP
rs1383436661 1006 dbSNP
rs1346927264 1014 dbSNP
rs534737012 1016 dbSNP
rs1019314357 1018 dbSNP
rs1293106470 1028 dbSNP
rs775039992 1029 dbSNP
rs1425690793 1032 dbSNP
rs996593684 1034 dbSNP
rs886047412 1035 dbSNP
rs369992151 1036 dbSNP
rs1460074471 1037 dbSNP
rs1422480244 1050 dbSNP
rs1193788766 1058 dbSNP
rs1026865366 1062 dbSNP
rs1240837461 1066 dbSNP
rs1215761613 1067 dbSNP
rs1313149920 1075 dbSNP
rs1265454668 1083 dbSNP
rs1221854815 1085 dbSNP
rs1244364622 1095 dbSNP
rs1323098812 1096 dbSNP
rs889919677 1097 dbSNP
rs1384018027 1101 dbSNP
rs1185152555 1103 dbSNP
rs1287043446 1108 dbSNP
rs1430003328 1109 dbSNP
rs1172984701 1115 dbSNP
rs376153776 1120 dbSNP
rs1429454853 1122 dbSNP
rs1019828980 1123 dbSNP
rs1171004183 1124 dbSNP
rs1428188885 1124 dbSNP
rs547262170 1124 dbSNP
rs886047413 1124 dbSNP
rs989439414 1128 dbSNP
rs1467836245 1131 dbSNP
rs1186435576 1132 dbSNP
rs2736630 1134 dbSNP
rs1483874090 1136 dbSNP
rs552819280 1143 dbSNP
rs886047414 1151 dbSNP
rs552354954 1153 dbSNP
rs1429879540 1157 dbSNP
rs1461001931 1158 dbSNP
rs952498561 1159 dbSNP
rs979967514 1161 dbSNP
rs1229974733 1169 dbSNP
rs1363862131 1173 dbSNP
rs886047415 1174 dbSNP
rs1400357757 1175 dbSNP
rs1282946114 1177 dbSNP
rs1338398192 1179 dbSNP
rs1321664396 1189 dbSNP
rs569316988 1190 dbSNP
rs1225430165 1195 dbSNP
rs886047416 1203 dbSNP
rs1298395571 1212 dbSNP
rs1463257676 1218 dbSNP
rs1352205054 1235 dbSNP
rs547879223 1238 dbSNP
rs938169780 1243 dbSNP
rs1053930142 1265 dbSNP
rs1316862445 1268 dbSNP
rs1214332631 1276 dbSNP
rs915516220 1279 dbSNP
rs945671684 1280 dbSNP
rs959829931 1281 dbSNP
rs1043018730 1282 dbSNP
rs992610805 1283 dbSNP
rs1361740362 1284 dbSNP
rs1267739754 1291 dbSNP
rs1317032975 1293 dbSNP
rs1479220207 1295 dbSNP
rs913105885 1295 dbSNP
rs1381756660 1304 dbSNP
rs902882242 1313 dbSNP
rs1425208757 1318 dbSNP
rs945461733 1320 dbSNP
rs1042893798 1325 dbSNP
rs1393921632 1325 dbSNP
rs1156896201 1330 dbSNP
rs925278782 1332 dbSNP
rs542854347 1334 dbSNP
rs1424717678 1335 dbSNP
rs1366941418 1342 dbSNP
rs1008305719 1344 dbSNP
rs188246270 1346 dbSNP
rs899556515 1349 dbSNP
rs1364673058 1353 dbSNP
rs1417502622 1356 dbSNP
rs886047417 1356 dbSNP
rs996646970 1356 dbSNP
rs915261538 1358 dbSNP
rs373943966 1361 dbSNP
rs1490858619 1364 dbSNP
rs1049971139 1365 dbSNP
rs1289761417 1365 dbSNP
rs1302228040 1367 dbSNP
rs576331425 1370 dbSNP
rs1008524582 1380 dbSNP
rs1041217197 1387 dbSNP
rs79395513 1396 dbSNP
rs1261055646 1402 dbSNP
rs1240945818 1406 dbSNP
rs897345315 1418 dbSNP
rs952642365 1419 dbSNP
rs1275634476 1424 dbSNP
rs1198833647 1431 dbSNP
rs1206867417 1431 dbSNP
rs1223676602 1431 dbSNP
rs1259938915 1431 dbSNP
rs1262320665 1431 dbSNP
rs1266782836 1431 dbSNP
rs1280753377 1431 dbSNP
rs1325281153 1431 dbSNP
rs1326541942 1431 dbSNP
rs1346786169 1431 dbSNP
rs1348270857 1431 dbSNP
rs1363648070 1431 dbSNP
rs1376765550 1431 dbSNP
rs1450915516 1431 dbSNP
rs1452033891 1431 dbSNP
rs1481551950 1431 dbSNP
rs201131651 1431 dbSNP
rs35460383 1431 dbSNP
rs5786797 1431 dbSNP
rs886047419 1431 dbSNP
rs886047420 1431 dbSNP
rs1027170987 1432 dbSNP
rs1337812221 1433 dbSNP
rs1384633675 1433 dbSNP
rs762987781 1434 dbSNP
rs1001162165 1435 dbSNP
rs563751927 1435 dbSNP
rs886047421 1435 dbSNP
rs1374928079 1436 dbSNP
rs1475766214 1436 dbSNP
rs1195224170 1437 dbSNP
rs1034008648 1438 dbSNP
rs1354970198 1439 dbSNP
rs1462524230 1440 dbSNP
rs764649748 1440 dbSNP
rs886047422 1441 dbSNP
rs1225798134 1442 dbSNP
rs34885400 1442 dbSNP
rs1454897450 1443 dbSNP
rs886047423 1443 dbSNP
rs1410799404 1444 dbSNP
rs967628742 1444 dbSNP
rs1489738861 1445 dbSNP
rs978177937 1446 dbSNP
rs867694007 1447 dbSNP
rs1469232632 1448 dbSNP
rs878921330 1449 dbSNP
rs1302230981 1450 dbSNP
rs886047424 1450 dbSNP
rs1208913620 1451 dbSNP
rs1174967919 1452 dbSNP
rs936804736 1455 dbSNP
rs1049755919 1457 dbSNP
rs1438056372 1458 dbSNP
rs1491403584 1459 dbSNP
rs1293101160 1460 dbSNP
rs886047418 1460 dbSNP
rs886047425 1460 dbSNP
rs886047426 1460 dbSNP
rs35632884 1461 dbSNP
rs1162715837 1462 dbSNP
rs1376874743 1463 dbSNP
rs78439318 1463 dbSNP
rs1381022039 1464 dbSNP
rs1363436286 1465 dbSNP
rs11202606 1466 dbSNP
rs944260278 1472 dbSNP
rs1443152036 1484 dbSNP
rs1041334487 1487 dbSNP
rs897300541 1488 dbSNP
rs1409416510 1495 dbSNP
rs1366341344 1496 dbSNP
rs180953647 1500 dbSNP
rs1048106744 1501 dbSNP
rs1324528719 1502 dbSNP
rs1015926859 1512 dbSNP
rs775659811 1514 dbSNP
rs1234238321 1515 dbSNP
rs982074985 1516 dbSNP
rs701848 1517 dbSNP
rs959421683 1521 dbSNP
rs1225294937 1525 dbSNP
rs1001276804 1527 dbSNP
rs886047427 1530 dbSNP
rs1289548850 1531 dbSNP
rs550961951 1532 dbSNP
rs1313519216 1534 dbSNP
rs541494941 1539 dbSNP
rs1362099091 1540 dbSNP
rs1277996449 1548 dbSNP
rs1229234225 1555 dbSNP
rs1290228474 1557 dbSNP
rs751151588 1561 dbSNP
rs34140758 1566 dbSNP
rs906632485 1567 dbSNP
rs1305034552 1572 dbSNP
rs886047428 1573 dbSNP
rs895514088 1574 dbSNP
rs529908733 1576 dbSNP
rs886047429 1577 dbSNP
rs1201836454 1580 dbSNP
rs1020639063 1583 dbSNP
rs548599209 1584 dbSNP
rs1401048480 1588 dbSNP
rs943724467 1590 dbSNP
rs886047430 1592 dbSNP
rs1472069140 1597 dbSNP
rs1040657615 1598 dbSNP
rs1489665221 1599 dbSNP
rs1246606043 1613 dbSNP
rs568474293 1621 dbSNP
rs1446294086 1625 dbSNP
rs1282610646 1632 dbSNP
rs201650436 1632 dbSNP
rs1032885638 1633 dbSNP
rs958091939 1641 dbSNP
rs2142135 1645 dbSNP
rs985573368 1647 dbSNP
rs911199142 1653 dbSNP
rs888327663 1667 dbSNP
rs1367051565 1669 dbSNP
rs886047431 1670 dbSNP
rs1004416206 1677 dbSNP
rs569923405 1679 dbSNP
rs1408380058 1680 dbSNP
rs944040990 1690 dbSNP
rs868480994 1693 dbSNP
rs141857855 1696 dbSNP
rs1003564860 1698 dbSNP
rs35481105 1698 dbSNP
rs150265244 1703 dbSNP
rs754704111 1714 dbSNP
rs1187551122 1716 dbSNP
rs1240679558 1736 dbSNP
rs888644057 1736 dbSNP
rs959346621 1741 dbSNP
rs116248217 1746 dbSNP
rs1022798646 1750 dbSNP
rs1202089335 1759 dbSNP
rs1269912619 1762 dbSNP
rs886047432 1763 dbSNP
rs895461910 1769 dbSNP
rs1212393109 1778 dbSNP
rs1215022749 1791 dbSNP
rs1364029901 1795 dbSNP
rs1295377005 1797 dbSNP
rs546939869 1799 dbSNP
rs1406630512 1801 dbSNP
rs1019983328 1805 dbSNP
rs756887853 1805 dbSNP
rs768027159 1806 dbSNP
rs974945383 1808 dbSNP
rs920965632 1810 dbSNP
rs1170567055 1812 dbSNP
rs1430765737 1813 dbSNP
rs1417968575 1820 dbSNP
rs1318075225 1821 dbSNP
rs932319101 1822 dbSNP
rs553022623 1826 dbSNP
rs1048137016 1828 dbSNP
rs1202483585 1831 dbSNP
rs1000141743 1833 dbSNP
rs772654487 1834 dbSNP
rs1210870955 1836 dbSNP
rs1444013481 1837 dbSNP
rs1251925272 1838 dbSNP
rs953203363 1842 dbSNP
rs1206688355 1857 dbSNP
rs1305876670 1858 dbSNP
rs1272383385 1862 dbSNP
rs1227646174 1866 dbSNP
rs1383174625 1872 dbSNP
rs762499494 1876 dbSNP
rs1188026884 1880 dbSNP
rs750754949 1894 dbSNP
rs1463045382 1895 dbSNP
rs1368243421 1909 dbSNP
rs1168500453 1914 dbSNP
rs1425859006 1921 dbSNP
rs1474286673 1923 dbSNP
rs1185908861 1929 dbSNP
rs1018372293 1940 dbSNP
rs1179240010 1945 dbSNP
rs567800059 1946 dbSNP
rs1037249444 1947 dbSNP
rs35914322 1955 dbSNP
rs41284072 1956 dbSNP
rs576294635 1958 dbSNP
rs754624881 1962 dbSNP
rs1242314198 1977 dbSNP
rs1174281004 1982 dbSNP
rs138981406 1984 dbSNP
rs1392835132 1985 dbSNP
rs1408956956 1985 dbSNP
rs1397069982 1987 dbSNP
rs1033587010 1991 dbSNP
rs879944859 1991 dbSNP
rs895186711 2006 dbSNP
rs1368028983 2007 dbSNP
rs1010873237 2011 dbSNP
rs544118607 2025 dbSNP
rs1318107660 2026 dbSNP
rs886047433 2028 dbSNP
rs910025786 2034 dbSNP
rs937529889 2036 dbSNP
rs1325085162 2037 dbSNP
rs1055431580 2043 dbSNP
rs1364794611 2045 dbSNP
rs1161482536 2046 dbSNP
rs559017397 2051 dbSNP
rs577156522 2054 dbSNP
rs999715453 2055 dbSNP
rs886047434 2062 dbSNP
rs192484947 2066 dbSNP
rs558501841 2074 dbSNP
rs1488029908 2078 dbSNP
rs966175466 2093 dbSNP
rs1240657421 2103 dbSNP
rs902875889 2104 dbSNP
rs754229502 2110 dbSNP
rs886047435 2111 dbSNP
rs181468070 2115 dbSNP
rs1223571042 2119 dbSNP
rs975007193 2124 dbSNP
rs1222389837 2127 dbSNP
rs1322129546 2129 dbSNP
rs1386718227 2130 dbSNP
rs1000490928 2142 dbSNP
rs1054395152 2148 dbSNP
rs922150661 2157 dbSNP
rs574993688 2163 dbSNP
rs542009439 2167 dbSNP
rs1177476010 2169 dbSNP
rs186996550 2174 dbSNP
rs965453418 2175 dbSNP
rs998307115 2179 dbSNP
rs1432529205 2182 dbSNP
rs1262119765 2184 dbSNP
rs11202607 2186 dbSNP
rs754989049 2189 dbSNP
rs1197386909 2190 dbSNP
rs1267095158 2193 dbSNP
rs1036771211 2195 dbSNP
rs1431486550 2200 dbSNP
rs886047436 2201 dbSNP
rs886047437 2204 dbSNP
rs552431817 2205 dbSNP
rs939164463 2206 dbSNP
rs1327548786 2220 dbSNP
rs745975387 2224 dbSNP
rs1449189202 2225 dbSNP
rs910138972 2228 dbSNP
rs1055049453 2234 dbSNP
rs1388454232 2237 dbSNP
rs1402815408 2244 dbSNP
rs958830672 2245 dbSNP
rs895029633 2257 dbSNP
rs1172098370 2259 dbSNP
rs1400080780 2259 dbSNP
rs1465442803 2261 dbSNP
rs775116816 2261 dbSNP
rs886047438 2261 dbSNP
rs1044092433 2264 dbSNP
rs1403910442 2265 dbSNP
rs902492142 2268 dbSNP
rs991615120 2269 dbSNP
rs1280938395 2274 dbSNP
rs1332370019 2289 dbSNP
rs917438585 2295 dbSNP
rs1199363490 2299 dbSNP
rs1339526847 2300 dbSNP
rs1278954814 2306 dbSNP
rs564263681 2309 dbSNP
rs780059644 2314 dbSNP
rs1348370078 2319 dbSNP
rs528086505 2322 dbSNP
rs1012788786 2341 dbSNP
rs1041479711 2344 dbSNP
rs1454745839 2346 dbSNP
rs924247421 2355 dbSNP
rs1338948764 2356 dbSNP
rs1333816513 2363 dbSNP
rs1019028345 2370 dbSNP
rs966186819 2372 dbSNP
rs935680911 2380 dbSNP
rs1427745585 2383 dbSNP
rs1389275674 2389 dbSNP
rs1054337596 2391 dbSNP
rs1473681580 2392 dbSNP
rs1029213448 2403 dbSNP
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rs889026524 2414 dbSNP
rs34761252 2416 dbSNP
rs1040215449 2417 dbSNP
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rs1203546885 2424 dbSNP
rs1342114254 2424 dbSNP
rs1292904894 2425 dbSNP
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rs567776779 2428 dbSNP
rs1354738703 2430 dbSNP
rs961063356 2431 dbSNP
rs190099872 2433 dbSNP
rs886047440 2438 dbSNP
rs998649990 2451 dbSNP
rs1306289601 2462 dbSNP
rs927658366 2473 dbSNP
rs1025746654 2479 dbSNP
rs1369850414 2483 dbSNP
rs1303729428 2489 dbSNP
rs1406873458 2490 dbSNP
rs939174591 2494 dbSNP
rs1365388746 2495 dbSNP
rs1470311793 2498 dbSNP
rs149401400 2506 dbSNP
rs548348131 2508 dbSNP
rs1423108985 2509 dbSNP
rs1224518538 2513 dbSNP
rs951420612 2514 dbSNP
rs569895598 2516 dbSNP
rs1450172832 2524 dbSNP
rs1300973211 2537 dbSNP
rs1224499664 2538 dbSNP
rs1331508774 2546 dbSNP
rs888127106 2548 dbSNP
rs1005558916 2551 dbSNP
rs537283839 2552 dbSNP
rs1392424988 2557 dbSNP
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rs886047441 2559 dbSNP
rs1227829579 2566 dbSNP
rs1386847391 2581 dbSNP
rs916516810 2585 dbSNP
rs1275354824 2592 dbSNP
rs1016929522 2600 dbSNP
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rs1309844552 2610 dbSNP
rs1390360384 2627 dbSNP
rs958929101 2631 dbSNP
rs1429452753 2633 dbSNP
rs1043635752 2656 dbSNP
rs1477342508 2660 dbSNP
rs1246438284 2661 dbSNP
rs902553003 2668 dbSNP
rs991729702 2678 dbSNP
rs1243478058 2681 dbSNP
rs1267465603 2682 dbSNP
rs886047442 2683 dbSNP
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rs1488898247 2685 dbSNP
rs886047443 2685 dbSNP
rs1303508545 2689 dbSNP
rs1040868520 2700 dbSNP
rs1274238278 2725 dbSNP
rs1435510595 2732 dbSNP
rs1367182746 2737 dbSNP
rs886047444 2747 dbSNP
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rs1318108670 2771 dbSNP
rs886047445 2772 dbSNP
rs763833268 2773 dbSNP
rs867027371 2774 dbSNP
rs971606435 2776 dbSNP
rs1412304065 2783 dbSNP
rs574096019 2787 dbSNP
rs1248463294 2788 dbSNP
rs886047446 2790 dbSNP
rs1246586808 2791 dbSNP
rs1459123042 2801 dbSNP
rs1179871507 2808 dbSNP
rs996321921 2810 dbSNP
rs368180514 2817 dbSNP
rs1277828735 2818 dbSNP
rs776568434 2821 dbSNP
rs11591427 2822 dbSNP
rs182746814 2828 dbSNP
rs1433834521 2840 dbSNP
rs1297134324 2841 dbSNP
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rs371289955 2848 dbSNP
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rs1397547940 2865 dbSNP
rs1034779270 2867 dbSNP
rs1432171697 2868 dbSNP
rs960420863 2873 dbSNP
rs1168377390 2895 dbSNP
rs1445670051 2897 dbSNP
rs540495271 2899 dbSNP
rs1180409708 2901 dbSNP
rs910244814 2904 dbSNP
rs886047447 2906 dbSNP
rs1332022480 2909 dbSNP
rs990549529 2934 dbSNP
rs187266004 2957 dbSNP
rs916445163 2968 dbSNP
rs574955389 2971 dbSNP
rs979762264 2992 dbSNP
rs1322175145 3005 dbSNP
rs542319798 3013 dbSNP
rs1314552206 3014 dbSNP
rs923848247 3028 dbSNP
rs563805612 3032 dbSNP
rs1369223120 3033 dbSNP
rs886047448 3034 dbSNP
rs1040329250 3044 dbSNP
rs1458733724 3046 dbSNP
rs1370623193 3047 dbSNP
rs901651453 3048 dbSNP
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rs1184408482 3062 dbSNP
rs1050464448 3065 dbSNP
rs1249814379 3081 dbSNP
rs886047449 3084 dbSNP
rs1320169309 3085 dbSNP
rs1249520948 3086 dbSNP
rs1204418658 3091 dbSNP
rs929158248 3100 dbSNP
rs1047557000 3103 dbSNP
rs1320769134 3106 dbSNP
rs887191814 3107 dbSNP
rs1243075254 3108 dbSNP
rs1288645198 3114 dbSNP
rs1460325977 3116 dbSNP
rs575385694 3117 dbSNP
rs1006348951 3118 dbSNP
rs1183987210 3127 dbSNP
rs1015597345 3136 dbSNP
rs1257253065 3138 dbSNP
rs898045925 3150 dbSNP
rs545725183 3151 dbSNP
rs1034707460 3160 dbSNP
rs960347269 3167 dbSNP
rs886047450 3178 dbSNP
rs1471643671 3187 dbSNP
rs1421000658 3194 dbSNP
rs1411345873 3204 dbSNP
rs1016877141 3206 dbSNP
rs1180913321 3212 dbSNP
rs1023352328 3213 dbSNP
rs1289339305 3215 dbSNP
rs1207822285 3229 dbSNP
rs189780354 3229 dbSNP
rs1170706934 3233 dbSNP
rs1268366611 3242 dbSNP
rs968294963 3245 dbSNP
rs1326393991 3261 dbSNP
rs894493599 3262 dbSNP
rs1464452145 3263 dbSNP
rs923873373 3264 dbSNP
rs1304486423 3266 dbSNP
rs1299866492 3268 dbSNP
rs1386553990 3271 dbSNP
rs1366443639 3280 dbSNP
rs1013097841 3283 dbSNP
rs1322740151 3291 dbSNP
rs747959604 3293 dbSNP
rs1455847922 3294 dbSNP
rs971937248 3295 dbSNP
rs1381426979 3297 dbSNP
rs1293789321 3301 dbSNP
rs528385253 3311 dbSNP
rs935288342 3312 dbSNP
rs975960684 3325 dbSNP
rs977607458 3346 dbSNP
rs1219338953 3349 dbSNP
rs546156099 3357 dbSNP
rs1050471196 3362 dbSNP
rs957129003 3368 dbSNP
rs909263093 3375 dbSNP
rs989929809 3377 dbSNP
rs1260663276 3394 dbSNP
rs942203985 3395 dbSNP
rs1346585382 3396 dbSNP
rs1228388162 3402 dbSNP
rs1036506515 3405 dbSNP
rs201866164 3405 dbSNP
rs897970115 3406 dbSNP
rs1433104123 3407 dbSNP
rs1003155429 3409 dbSNP
rs1335152297 3416 dbSNP
rs1257072875 3417 dbSNP
rs1485776966 3418 dbSNP
rs1185136598 3420 dbSNP
rs1260594911 3421 dbSNP
rs183009813 3423 dbSNP
rs1193795693 3425 dbSNP
rs1170281399 3429 dbSNP
rs1003863710 3440 dbSNP
rs1295729539 3440 dbSNP
rs1208479103 3443 dbSNP
rs1247279196 3443 dbSNP
rs1339217435 3443 dbSNP
rs1373465182 3443 dbSNP
rs1443581166 3443 dbSNP
rs763859619 3443 dbSNP
rs769667659 3444 dbSNP
rs1414042545 3445 dbSNP
rs1371051726 3449 dbSNP
rs1412245000 3451 dbSNP
rs528887876 3454 dbSNP
rs1427562042 3455 dbSNP
rs1418540657 3456 dbSNP
rs910192519 3456 dbSNP
rs1473592463 3457 dbSNP
rs1178216796 3458 dbSNP
rs943036473 3459 dbSNP
rs1472656553 3460 dbSNP
rs550247784 3460 dbSNP
rs1437552555 3461 dbSNP
rs1291046647 3462 dbSNP
rs55761968 3462 dbSNP
rs1292964022 3463 dbSNP
rs929248812 3463 dbSNP
rs1352465028 3464 dbSNP
rs535200721 3464 dbSNP
rs1015326882 3465 dbSNP
rs71487196 3469 dbSNP
rs1407922007 3470 dbSNP
rs1023403294 3472 dbSNP
rs1323990490 3473 dbSNP
rs1296051548 3475 dbSNP
rs1362713734 3478 dbSNP
rs1388092400 3484 dbSNP
rs1400794376 3484 dbSNP
rs71487197 3487 dbSNP
rs1163845531 3502 dbSNP
rs1413551360 3513 dbSNP
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rs1282847313 3515 dbSNP
rs188761136 3516 dbSNP
rs1365639660 3519 dbSNP
rs967800151 3521 dbSNP
rs773167486 3529 dbSNP
rs7899343 3536 dbSNP
rs193256751 3538 dbSNP
rs1272763494 3556 dbSNP
rs765239024 3556 dbSNP
rs1331235404 3559 dbSNP
rs1316773034 3562 dbSNP
rs956740125 3568 dbSNP
rs1214120809 3572 dbSNP
rs766006725 3574 dbSNP
rs923151026 3585 dbSNP
rs953385312 3600 dbSNP
rs986063464 3603 dbSNP
rs909304726 3609 dbSNP
rs942151055 3612 dbSNP
rs1457447946 3615 dbSNP
rs1036841284 3619 dbSNP
rs571089818 3625 dbSNP
rs866455525 3627 dbSNP
rs1399668290 3644 dbSNP
rs938827379 3647 dbSNP
rs776424062 3650 dbSNP
rs12249651 3654 dbSNP
rs1057400230 3658 dbSNP
rs1477208975 3665 dbSNP
rs1252766060 3667 dbSNP
rs535027543 3674 dbSNP
rs868014801 3676 dbSNP
rs773937535 3680 dbSNP
rs999539820 3685 dbSNP
rs1418378584 3698 dbSNP
rs1011938026 3702 dbSNP
rs1044760231 3706 dbSNP
rs903506093 3715 dbSNP
rs1220886271 3716 dbSNP
rs1000656330 3720 dbSNP
rs1302452345 3724 dbSNP
rs1420059502 3730 dbSNP
rs1031828462 3742 dbSNP
rs1348350219 3744 dbSNP
rs1286802560 3751 dbSNP
rs759333613 3755 dbSNP
rs989877189 3759 dbSNP
rs1017368912 3767 dbSNP
rs1336640411 3774 dbSNP
rs964341745 3775 dbSNP
rs146367554 3777 dbSNP
rs997269498 3778 dbSNP
rs922968808 3793 dbSNP
rs1451764827 3797 dbSNP
rs754207343 3800 dbSNP
rs1186207130 3807 dbSNP
rs775375557 3816 dbSNP
rs1239292431 3819 dbSNP
rs1212103566 3823 dbSNP
rs1484664572 3828 dbSNP
rs953271073 3831 dbSNP
rs1228834472 3843 dbSNP
rs1344137272 3844 dbSNP
rs985990017 3845 dbSNP
rs185012826 3851 dbSNP
rs1379208866 3854 dbSNP
rs763535823 3867 dbSNP
rs1290585072 3869 dbSNP
rs1449460205 3881 dbSNP
rs200568059 3886 dbSNP
rs372571424 3886 dbSNP
rs778263539 3886 dbSNP
rs1432001141 3887 dbSNP
rs1169926083 3892 dbSNP
rs1353136528 3892 dbSNP
rs909021100 3893 dbSNP
rs1424649700 3894 dbSNP
rs941870464 3897 dbSNP
rs1180172313 3905 dbSNP
rs1480007609 3907 dbSNP
rs1038382262 3910 dbSNP
rs1205863027 3912 dbSNP
rs1483873124 3912 dbSNP
rs375709234 3912 dbSNP
rs1382076403 3915 dbSNP
rs529457056 3916 dbSNP
rs1314478509 3917 dbSNP
rs1230916849 3919 dbSNP
rs528681218 3922 dbSNP
rs1289462142 3923 dbSNP
rs1412228299 3926 dbSNP
rs938845343 3929 dbSNP
rs1297989302 3937 dbSNP
rs765480550 3938 dbSNP
rs1458783197 3945 dbSNP
rs761378460 3945 dbSNP
rs1165717133 3947 dbSNP
rs915986305 3949 dbSNP
rs531822223 3969 dbSNP
rs188725691 3972 dbSNP
rs1334030176 3984 dbSNP
rs191569505 3985 dbSNP
rs1176378159 3987 dbSNP
rs1488722585 3988 dbSNP
rs903559637 3988 dbSNP
rs936297104 3990 dbSNP
rs1333435566 3995 dbSNP
rs752772727 3996 dbSNP
rs1230723897 4000 dbSNP
rs1353855381 4000 dbSNP
rs1229715158 4001 dbSNP
rs1334487778 4001 dbSNP
rs1387708889 4002 dbSNP
rs1370256639 4005 dbSNP
rs1190209392 4007 dbSNP
rs907228014 4007 dbSNP
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rs183906511 4014 dbSNP
rs1161430418 4025 dbSNP
rs188690010 4025 dbSNP
rs780111875 4030 dbSNP
rs1196200399 4035 dbSNP
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rs1239937382 4041 dbSNP
rs892184921 4042 dbSNP
rs1191318923 4043 dbSNP
rs1053799338 4046 dbSNP
rs997320062 4054 dbSNP
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rs1260640322 4059 dbSNP
rs1011761161 4063 dbSNP
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rs888935096 4069 dbSNP
rs535998922 4070 dbSNP
rs1007509344 4072 dbSNP
rs1419072615 4074 dbSNP
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rs3069410 4083 dbSNP
rs397838211 4083 dbSNP
rs191253899 4085 dbSNP
rs540117541 4092 dbSNP
rs1466517105 4093 dbSNP
rs1396609562 4095 dbSNP
rs964455160 4097 dbSNP
rs1171502134 4098 dbSNP
rs755248588 4100 dbSNP
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rs1268310728 4395 dbSNP
rs527703056 4395 dbSNP
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rs992953581 4416 dbSNP
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rs547847959 4496 dbSNP
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rs558036625 4519 dbSNP
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rs535800994 4541 dbSNP
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rs1359518917 4559 dbSNP
rs145930149 4565 dbSNP
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rs1252666480 4589 dbSNP
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rs950378967 4593 dbSNP
rs1448883868 4597 dbSNP
rs754321761 4604 dbSNP
rs1222021499 4612 dbSNP
rs182441621 4615 dbSNP
rs1236272233 4620 dbSNP
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rs572938444 4631 dbSNP
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rs1430817192 4643 dbSNP
rs1004946068 4647 dbSNP
rs1316781488 4649 dbSNP
rs1273015936 4655 dbSNP
rs1346965860 4665 dbSNP
rs540079072 4667 dbSNP
rs186631475 4673 dbSNP
rs1394701843 4675 dbSNP
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rs1014231393 4679 dbSNP
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rs1023398486 4701 dbSNP
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rs181704450 4769 dbSNP
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rs1237226331 4775 dbSNP
rs989217875 4794 dbSNP
rs1033621934 4799 dbSNP
rs956223178 4807 dbSNP
rs1375237581 4811 dbSNP
rs1169415791 4812 dbSNP
rs1379894269 4818 dbSNP
rs1417686754 4829 dbSNP
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rs989060800 4841 dbSNP
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rs35177748 4852 dbSNP
rs1189985270 4853 dbSNP
rs954384868 4863 dbSNP
rs947590035 4864 dbSNP
rs1279366167 4865 dbSNP
rs1039322042 4874 dbSNP
rs1360694656 4876 dbSNP
rs1385751806 4878 dbSNP
rs1308857688 4888 dbSNP
rs1270524645 4894 dbSNP
rs1320963212 4895 dbSNP
rs987067982 4896 dbSNP
rs1295593914 4903 dbSNP
rs1413498304 4908 dbSNP
rs1355183550 4913 dbSNP
rs1299071042 4914 dbSNP
rs1332794334 4926 dbSNP
rs185664312 4932 dbSNP
rs76945565 4941 dbSNP
rs1051970183 4942 dbSNP
rs1351305050 4943 dbSNP
rs553438770 4944 dbSNP
rs1166946546 4959 dbSNP
rs886184674 4970 dbSNP
rs1256764738 4971 dbSNP
rs1004656707 4975 dbSNP
rs920463558 4977 dbSNP
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rs1230755922 4983 dbSNP
rs775206752 4984 dbSNP
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rs1274539967 4993 dbSNP
rs1230969509 4998 dbSNP
rs895708457 5000 dbSNP
rs778861760 5014 dbSNP
rs1015867982 5018 dbSNP
rs1355837188 5020 dbSNP
rs1393498801 5022 dbSNP
rs1371633511 5025 dbSNP
rs898850774 5032 dbSNP
rs1012098578 5040 dbSNP
rs1023511647 5044 dbSNP
rs148608390 5046 dbSNP
rs1178629061 5047 dbSNP
rs1000720613 5048 dbSNP
rs1236880125 5051 dbSNP
rs540524962 5055 dbSNP
rs1033094150 5062 dbSNP
rs751686778 5066 dbSNP
rs1405551793 5085 dbSNP
rs867448643 5089 dbSNP
rs758677110 5100 dbSNP
rs190429014 5113 dbSNP
rs1254548565 5115 dbSNP
rs1211263980 5119 dbSNP
rs142077584 5121 dbSNP
rs1289597206 5122 dbSNP
rs550925852 5125 dbSNP
rs1329060790 5134 dbSNP
rs755019299 5135 dbSNP
rs1161066915 5138 dbSNP
rs781088972 5146 dbSNP
rs1306771662 5155 dbSNP
rs1235525076 5160 dbSNP
rs1373436060 5161 dbSNP
rs1392321490 5164 dbSNP
rs1029882051 5169 dbSNP
rs1440181867 5171 dbSNP
rs1386829594 5177 dbSNP
rs1289328932 5180 dbSNP
rs1455313638 5185 dbSNP
rs988924258 5193 dbSNP
rs1330666770 5201 dbSNP
rs955645809 5219 dbSNP
rs41284076 5241 dbSNP
rs1448736994 5243 dbSNP
rs1454593966 5252 dbSNP
rs1309651137 5268 dbSNP
rs1017722761 5277 dbSNP
rs1191366116 5283 dbSNP
rs1432032232 5284 dbSNP
rs539857720 5288 dbSNP
rs1242931021 5290 dbSNP
rs1485159732 5295 dbSNP
rs973566365 5313 dbSNP
rs1267444518 5317 dbSNP
rs920325834 5322 dbSNP
rs756230864 5323 dbSNP
rs983260727 5333 dbSNP
rs1233876637 5335 dbSNP
rs35101638 5336 dbSNP
rs1327062247 5345 dbSNP
rs557963676 5347 dbSNP
rs1297775440 5351 dbSNP
rs147513181 5352 dbSNP
rs369529395 5362 dbSNP
rs1044326435 5364 dbSNP
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rs1459447835 5378 dbSNP
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rs935977572 5381 dbSNP
rs74146238 5384 dbSNP
rs1171305992 5391 dbSNP
rs891848649 5395 dbSNP
rs933625335 5399 dbSNP
rs1426274943 5401 dbSNP
rs1263093217 5402 dbSNP
rs1189290082 5407 dbSNP
rs1029814747 5410 dbSNP
rs891288184 5412 dbSNP
rs533696498 5414 dbSNP
rs1007136280 5423 dbSNP
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rs1011877827 5576 dbSNP
rs1179874000 5601 dbSNP
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rs1253918464 5605 dbSNP
rs1215617237 5612 dbSNP
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rs946169344 5622 dbSNP
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rs1237756795 5628 dbSNP
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rs906441007 5660 dbSNP
rs1387824107 5663 dbSNP
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rs1395910818 5681 dbSNP
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rs1175719185 5771 dbSNP
rs745764516 5781 dbSNP
rs1342518083 5783 dbSNP
rs1424791556 5788 dbSNP
rs186122957 5796 dbSNP
rs1187175171 5804 dbSNP
rs968822963 5823 dbSNP
rs1219319229 5834 dbSNP
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rs540795798 5844 dbSNP
rs41284078 5846 dbSNP
rs1243709313 5853 dbSNP
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rs954251850 5861 dbSNP
rs1256915406 5867 dbSNP
rs950352893 5871 dbSNP
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rs1399953011 5928 dbSNP
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rs987751878 5962 dbSNP
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rs1037380690 5990 dbSNP
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rs562290135 6021 dbSNP
rs990466212 6022 dbSNP
rs1438991245 6035 dbSNP
rs191848908 6038 dbSNP
rs913274615 6040 dbSNP
rs1217537471 6042 dbSNP
rs920338567 6052 dbSNP
rs1336095276 6053 dbSNP
rs947847558 6056 dbSNP
rs1295729068 6058 dbSNP
rs1226897966 6065 dbSNP
rs473354 6069 dbSNP
rs1186536112 6074 dbSNP
rs1051134397 6075 dbSNP
rs1424402818 6082 dbSNP
rs1444678590 6083 dbSNP
rs139316712 6087 dbSNP
rs373120049 6087 dbSNP
rs549302381 6087 dbSNP
rs754938261 6087 dbSNP
rs550977540 6089 dbSNP
rs1418478670 6090 dbSNP
rs1431330665 6098 dbSNP
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rs906227538 6102 dbSNP
rs1003842584 6104 dbSNP
rs1039899145 6104 dbSNP
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rs1395515074 6112 dbSNP
rs995804814 6116 dbSNP
rs892259598 6117 dbSNP
rs1010737417 6125 dbSNP
rs773622448 6131 dbSNP
rs139203450 6134 dbSNP
rs996288129 6136 dbSNP
rs551758251 6141 dbSNP
rs1225879282 6144 dbSNP
rs1374934407 6157 dbSNP
rs1362617671 6161 dbSNP
rs865778034 6164 dbSNP
rs1029378888 6169 dbSNP
rs1396799353 6175 dbSNP
rs184148472 6177 dbSNP
rs1292960937 6181 dbSNP
rs954750312 6187 dbSNP
rs988090944 6189 dbSNP
rs1159550981 6192 dbSNP
rs1441390081 6208 dbSNP
rs1378032525 6210 dbSNP
rs1177641221 6213 dbSNP
rs1454295864 6218 dbSNP
rs763281750 6227 dbSNP
rs769556905 6240 dbSNP
rs962305969 6242 dbSNP
rs534046526 6243 dbSNP
rs1261884100 6244 dbSNP
rs1218378324 6246 dbSNP
rs766911725 6248 dbSNP
rs1024073333 6250 dbSNP
rs1235324111 6251 dbSNP
rs1373233300 6253 dbSNP
rs971112855 6255 dbSNP
rs574085926 6258 dbSNP
rs1001674003 6277 dbSNP
rs1289382991 6282 dbSNP
rs1283458008 6291 dbSNP
rs920786385 6293 dbSNP
rs947793797 6295 dbSNP
rs1355347280 6308 dbSNP
rs1157635078 6314 dbSNP
rs1434919412 6319 dbSNP
rs1044835348 6326 dbSNP
rs927597219 6331 dbSNP
rs1215927791 6343 dbSNP
rs1245668107 6345 dbSNP
rs1196113166 6354 dbSNP
rs939038158 6368 dbSNP
rs1052565438 6376 dbSNP
rs957430156 6383 dbSNP
rs892385281 6385 dbSNP
rs1487482028 6388 dbSNP
rs913117677 6394 dbSNP
rs149918220 6405 dbSNP
rs1212092366 6409 dbSNP
rs1043563306 6426 dbSNP
rs1253547660 6441 dbSNP
rs1254557523 6442 dbSNP
rs1232542681 6446 dbSNP
rs1308170825 6450 dbSNP
rs1296146017 6451 dbSNP
rs1438854205 6459 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Article - Kato M; Putta S; Wang M; Yuan H; Lanting L; et al.
- Nature cell biology, 2009
Akt kinase is activated by transforming growth factor-beta1 (TGF-beta) in diabetic kidneys, and has important roles in fibrosis, hypertrophy and cell survival in glomerular mesangial cells. However, the mechanisms of Akt activation by TGF-beta are not fully understood. Here we show that TGF-beta activates Akt in glomerular mesangial cells by inducing the microRNAs (miRNAs) miR-216a and miR-217, both of which target PTEN (phosphatase and tensin homologue), an inhibitor of Akt activation. These miRNAs are located within the second intron of a non-coding RNA (RP23-298H6.1-001). The RP23 promoter was activated by TGF-beta and miR-192 through E-box-regulated mechanisms, as shown previously. Akt activation by these miRs led to glomerular mesangial cell survival and hypertrophy, which were similar to the effects of activation by TGF-beta. These studies reveal a mechanism of Akt activation through PTEN downregulation by two miRs, which are regulated by upstream miR-192 and TGF-beta. Due to the diversity of PTEN function, this miR-amplifying circuit may have key roles, not only in kidney disorders, but also in other diseases.
LinkOut: [PMID: 19543271]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Location of target site 3'UTR
Article - Inui M; Martello G; Piccolo S
- Nature reviews. Molecular cell biology, 2010
MicroRNAs (miRNAs) are integral elements in the post-transcriptional control of gene expression. After the identification of hundreds of miRNAs, the challenge is now to understand their specific biological function. Signalling pathways are ideal candidates for miRNA-mediated regulation owing to the sharp dose-sensitive nature of their effects. Indeed, emerging evidence suggests that miRNAs affect the responsiveness of cells to signalling molecules such as transforming growth factor-beta, WNT, Notch and epidermal growth factor. As such, miRNAs serve as nodes of signalling networks that ensure homeostasis and regulate cancer, metastasis, fibrosis and stem cell biology.
LinkOut: [PMID: 20216554]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions PLC/PRF/5
Location of target site 3'UTR
Tools used in this research miRecord
Original Description (Extracted from the article) ... SMAD7 and PTEN are identified as two functional downstream targets of miR-216a /217 ...

- Xia H; Ooi LL; Hui KM, 2013, Hepatology (Baltimore, Md.).

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agUGUC----AACGGUCGACUCUAAu 5'
            ||||    || | | :||||||| 
Target 5' -cACAGAAAUUUUCAAUUUGAGAUUc 3'
 		1 - 25
Article - Xia H; Ooi LL; Hui KM
- Hepatology (Baltimore, Md.), 2013
UNLABELLED: Tumor recurrence and metastases are the major obstacles to improving the prognosis of patients with hepatocellular carcinoma (HCC). To identify novel risk factors associated with HCC recurrence and metastases, we have established a panel of recurrence-associated microRNAs (miRNAs) by comparing miRNA expression in recurrent and nonrecurrent human HCC tissue samples using microarrays (recurrence is defined as recurrent disease occurring within a 2-year time point of the original treatment). Among the panel, expression of the miR-216a/217 cluster was consistently and significantly up-regulated in HCC tissue samples and cell lines associated with early tumor recurrence, poor disease-free survival, and an epithelial-mesenchymal transition (EMT) phenotype. Stable overexpression of miR-216a/217-induced EMT increased the stem-like cell population, migration, and metastatic ability of epithelial HCC cells. Phosphatase and tensin homolog (PTEN) and mothers against decapentaplegic homolog 7 (SMAD7) were subsequently identified as two functional targets of miR-216a/217, and both PTEN and SMAD7 were down-regulated in HCC. Ectopic expression of PTEN or SMAD7 partially rescued miR-216a/217-mediated EMT, cell migration, and stem-like properties of HCC cells. Previously, SMAD7 was shown to be a transforming growth factor beta (TGF-beta) type 1 receptor antagonist. Here, we further demonstrated that overexpression of miR-216a/217 acted as a positive feedback regulator for the TGF-beta pathway and the canonical pathway involved in the activation of phosphoinositide 3-kinase/protein kinase K (PI3K/Akt) signaling in HCC cells. Additionally, activation of the TGF-beta- and PI3K/Akt-signaling pathways in HCC cells resulted in an acquired resistance to sorafenib, whereas blocking activation of the TGF-beta pathway overcame miR-216a/217-induced sorafenib resistance and prevented tumor metastases in HCC. CONCLUSION: Overexpression of miR-216a/217 activates the PI3K/Akt and TGF-beta pathways by targeting PTEN and SMAD7, contributing to hepatocarcinogenesis and tumor recurrence in HCC.
LinkOut: [PMID: 23471579]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.75 1.9e-5 0.908 1.1e-9 23 Click to see details
GSE28544 Breast cancer 0.684 1.1e-4 0.709 5.3e-5 24 Click to see details
GSE26953 Aortic valvular endothelial cells -0.527 4.1e-3 -0.594 1.1e-3 24 Click to see details
GSE21687 Ependynoma primary tumors 0.247 2.5e-2 -0.078 2.7e-1 64 Click to see details
GSE32688 Pancreatic cancer 0.324 3.5e-2 0.389 1.4e-2 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.361 3.8e-2 0.204 1.6e-1 25 Click to see details
GSE28260 Renal cortex and medulla 0.225 2.3e-1 0.001 5.0e-1 13 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.129 2.7e-1 0.491 6.3e-3 25 Click to see details
GSE27834 Pluripotent stem cells 0.156 2.8e-1 0.344 9.6e-2 16 Click to see details
GSE17306 Multiple myeloma -0.082 2.9e-1 0.379 3.6e-3 49 Click to see details
GSE14794 Lymphoblastoid cells -0.057 3.0e-1 -0.033 3.8e-1 90 Click to see details
GSE21849 B cell lymphoma -0.051 4.0e-1 0.113 2.8e-1 29 Click to see details
GSE19350 CNS germ cell tumors -0.073 4.1e-1 0.233 2.3e-1 12 Click to see details
GSE38226 Liver fibrosis 0.049 4.2e-1 -0.266 1.2e-1 21 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.015 4.7e-1 -0.564 4.8e-3 20 Click to see details
GSE17498 Multiple myeloma 0.005 4.9e-1 0.017 4.6e-1 40 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.353 0.04 0.278 0.09 25 Click to see details
HNSC 0.358 0.05 0.128 0.28 23 Click to see details
KIRC -0.275 0.07 -0.082 0.34 29 Click to see details
PRAD 0.193 0.15 -0.026 0.44 31 Click to see details
LUAD 0.371 0.16 0.400 0.14 9 Click to see details
LIHC -0.135 0.19 0.022 0.44 45 Click to see details
UCEC 0.251 0.24 0.236 0.26 10 Click to see details
KICH 0.228 0.25 0.382 0.12 11 Click to see details
CHOL -0.225 0.3 -0.238 0.29 8 Click to see details
THCA -0.078 0.3 -0.043 0.39 47 Click to see details
PAAD -0.206 0.4 0.000 0.5 4 Click to see details
BLCA -0.089 0.4 -0.152 0.34 10 Click to see details
KIRP -0.041 0.44 -0.079 0.38 18 Click to see details
LUSC 0.018 0.47 0.113 0.32 20 Click to see details
ESCA 0.058 0.47 0.000 0.5 4 Click to see details
STAD 0.012 0.48 0.077 0.37 20 Click to see details
STAD 0.012 0.48 0.077 0.37 20 Click to see details
STAD 0.012 0.48 0.077 0.37 20 Click to see details
148 hsa-miR-216a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000534 PTEN phosphatase and tensin homolog 4 3
MIRT005018 SIRT1 sirtuin 1 3 1
MIRT005964 CDC42 cell division cycle 42 2 1
MIRT005969 CD44 CD44 molecule (Indian blood group) 2 1
MIRT007154 SMAD7 SMAD family member 7 1 1
MIRT054887 BECN1 beclin 1 5 3
MIRT067588 METAP2 methionyl aminopeptidase 2 2 6
MIRT099144 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT162313 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT230668 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT256274 PHAX phosphorylated adaptor for RNA export 2 2
MIRT386817 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT386825 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT438816 HNF4A hepatocyte nuclear factor 4 alpha 1 1
MIRT464699 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465962 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466046 TMEM189 transmembrane protein 189 2 2
MIRT466482 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT472209 NGFRAP1 brain expressed X-linked 3 2 4
MIRT472562 NACC1 nucleus accumbens associated 1 2 4
MIRT478921 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT480121 CALR calreticulin 2 2
MIRT497754 OXGR1 oxoglutarate receptor 1 2 2
MIRT497967 TWISTNB TWIST neighbor 2 2
MIRT502882 CDK4 cyclin dependent kinase 4 2 8
MIRT510191 MON1B MON1 homolog B, secretory trafficking associated 2 4
MIRT512407 CD84 CD84 molecule 2 2
MIRT513739 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT526257 DROSHA drosha ribonuclease III 2 2
MIRT528968 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT529599 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT529776 ZNF486 zinc finger protein 486 2 2
MIRT530110 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530504 FADS6 fatty acid desaturase 6 2 2
MIRT531437 PAK1 p21 (RAC1) activated kinase 1 2 2
MIRT534445 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT537286 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT538451 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT543085 ACTB actin beta 2 2
MIRT550982 ZNF254 zinc finger protein 254 2 2
MIRT556259 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT556639 LAMC1 laminin subunit gamma 1 2 2
MIRT559127 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT561405 TUBB2A tubulin beta 2A class IIa 2 2
MIRT569677 SEC23B Sec23 homolog B, coat complex II component 2 4
MIRT574660 KLHL15 kelch like family member 15 2 2
MIRT575030 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT617683 JRKL JRK like 2 2
MIRT618540 SEMA5A semaphorin 5A 2 2
MIRT620805 C1orf27 chromosome 1 open reading frame 27 2 2
MIRT621569 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT622133 SP4 Sp4 transcription factor 2 2
MIRT624913 CTCFL CCCTC-binding factor like