| pre-miRNA Information | |
|---|---|
| pre-miRNA | hsa-mir-1-1 |
| Genomic Coordinates | chr20: 62554306 - 62554376 |
| Synonyms | MIRN1-1, hsa-mir-1-1, miRNA1-1, MIR1-1 |
| Description | Homo sapiens miR-1-1 stem-loop |
| Comment | Lagos-Quintana et al. . |
| RNA Secondary Structure |  |
| Associated Diseases |  |
| pre-miRNA | hsa-mir-1-2 |
| Genomic Coordinates | chr18: 21829004 - 21829088 |
| Synonyms | MIRN1-2, hsa-mir-1-2, miRNA1-2, MIR1-2 |
| Description | Homo sapiens miR-1-2 stem-loop |
| Comment | Lagos-Quintana et al. . |
| RNA Secondary Structure | |
| Associated Diseases |  |
| Mature miRNA Information | ||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mature miRNA | hsa-miR-1-3p | |||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence | 53| UGGAAUGUAAAGAAGUAUGUAU |74 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Evidence | Experimental | |||||||||||||||||||||||||||||||||||||||||||||||||
| Experiments | Cloned | |||||||||||||||||||||||||||||||||||||||||||||||||
| Editing Events in miRNAs |
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| SNPs in miRNA |
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| Putative Targets | ||||||||||||||||||||||||||||||||||||||||||||||||||
| miRNA Expression profile | |
|---|---|
| Human miRNA Tissue Atlas | |
| miRNAs in Extracellular Vesicles |
|
| Circulating MicroRNA Expression Profiling | |
| Biomarker Information |
| ||||||
|---|---|---|---|---|---|---|---|
| Gene Information | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol | HDAC4 | ||||||||||||||||||||
| Synonyms | AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA | ||||||||||||||||||||
| Description | histone deacetylase 4 | ||||||||||||||||||||
| Transcript | NM_006037 | ||||||||||||||||||||
| Expression | |||||||||||||||||||||
| Putative miRNA Targets on HDAC4 | |||||||||||||||||||||
| 3'UTR of HDAC4 (miRNA target sites are highlighted) |
>HDAC4|NM_006037|3'UTR 1 CACTCCCTCGAAGCTGCTGTTCTCTTGTCTGTCTGTCTCTGTCTTGAAGCTCAGCCAAGAAACTTTCCCGTGTCACGCCT 81 GCGTCCCACCGTGGGGCTCTCTTGGAGCACCCAGGGACACCCAGCGTGCAACAGCCACGGGAAGCCTTTCTGCCGCCCAG 161 GCCCACAGGTCTCGAGACGCACATGCACGCCTGGGCGTGGCAGCCTCACAGGGAACACGGGACAGACGCCGGCGACGCGC 241 AGACACACGGACACGCGGAAGCCAAGCACACTCTGGCGGGTCCCGCAAGGGACGCCGTGGAAGAAAGGAGCCTGTGGCAA 321 CAGGCGGCCGAGCTGCCGAATTCAGTTGACACGAGGCACAGAAAACAAATATCAAAGATCTAATAATACAAAACAAACTT 401 GATTAAAACTGGTGCTTAAAGTTTATTACCCACAACTCCACAGTCTCTGTGTAAACCACTCGACTCATCTTGTAGCTTAT 481 TTTTTTTTAAAGAGGACGTTTTCTACGGCTGTGGCCCGCCTCTGTGAACCATAGCGGTGTGCGGCGGGGGGTCTGCACCC 561 GGGTGGGGGACAGAGGGACCTTTAAAGAAAACAAAACTGGACAGAAACAGGAATGTGAGCTGGGGGAGCTGGCTTGAGTT 641 TCTCAAAAGCCATCGGAAGATGCGAGTTTGTGCCTTTTTTTTTATTGCTCTGGTGGATTTTTGTGGCTGGGTTTTCTGAA 721 GTCTGAGGAACAATGCCTTAAGAAAAAACAAACAGCAGGAATCGGTGGGACAGTTTCCTGTGGCCAGCCGAGCCTGGCAG 801 TGCTGGCACCGCGAGCTGGCCTGACGCCTCAAGCACGGGCACCAGCCGTCATCTCCGGGGCCAGGGGCTGCAGCCCGGCG 881 GTCCCTGTTTTGCTTTATTGCTGTTTAAGAAAAATGGAGGTAGTTCCAAAAAAGTGGCAAATCCCGTTGGAGGTTTTGAA 961 GTCCAACAAATTTTAAACGAATCCAAAGTGTTCTCACACGTCACATACGATTGAGCATCTCCATCTGGTCGTGAAGCATG 1041 TGGTAGGCACACTTGCAGTGTTACGATCGGAATGCTTTTTATTAAAAGCAAGTAGCATGAAGTATTGCTTAAATTTTAGG 1121 TATAAATAAATATATATATGTATAATATATATTCCAATGTATTCCAAGCTAAGAAACTTACTTGATTCTTATGAAATCTT 1201 GATAAAATATTTATAATGCATTTATAGAAAAAGTATATATATATATATAAAATGAATGCAGATTGCGAAGGTCCCTGCAA 1281 ATGGATGGCTTGTGAATTTGCTCTCAAGGTGCTTATGGAAAGGGATCCTGATTGATTGAAATTCATGTTTTCTCAAGCTC 1361 CAGATTGGCTAGATTTCAGATCGCCAACACATTCGCCACTGGGCAACTACCCTACAAGTTTGTACTTTCATTTTAATTAT 1441 TTTCTAACAGAACCGCTCCCGTCTCCAAGCCTTCATGCACATATGTACCTAATGAGTTTTTATAGCAAAGAATATAAATT 1521 TGCTGTTGATTTTTGTATGAATTTTTTCACAAAAAGATCCTGAATAAGCATTGTTTTATGAATTTTACATTTTTCCTCAC 1601 CATTTAGCAATTTTCTGAATGGTAATAATGTCTAAATCTTTTTCCTTTCTGAATTCTTGCTTGTACATTTTTTTTTACCT 1681 TTCAAAGGTTTTTAATTATTTTTGTTTTTATTTTTGTACGATGAGTTTTCTGCAGCGTACAGAATTGTTGCTGTCAGATT 1761 CTATTTTCAGAAAGTGAGAGGAGGGACCGTAGGTCTTTTCGGAGTGACACCAACGATTGTGTCTTTCCTGGTCTGTCCTA 1841 GGAGCTGTATAAAGAAGCCCAGGGGCTCTTTTTAACTTTCAACACTAGTAGTATTACGAGGGGTGGTGTGTTTTTCCCCT 1921 CCGTGGCAAGGGCAGGGAGGGTTGCTTAGGATGCCCGGCCACCCTGGGAGGCTTGCCAGATGCCGGGGGCAGTCAGCATT 2001 AATGAAACTCATGTTTAAACTTCTCTGACCACATCGTCAGGATAGAATTCTAACTTGAGTTTTCCAAAGACCTTTTGAGC 2081 ATGTCAGCAATGCATGGGGCACACGTGGGGCTCTTTACCCACTTGGGTTTTTCCACTGCAGCCACGTGGCCAGCCCTGGA 2161 TTTTGGAGCCTGTGGCTGCAAGGAACCCAGGGACCCTTGTTGCCTGGTGAACCTGCAGGGAGGGTATGATTGCCTGACCA 2241 GGACAGCCAGTCTTTACTCTTTTTCTCTTCAACAGTAACTGACAGTCACGTTTTACTGGTAACTTATTTTCCAGCACATG 2321 AAGCCACCAGTTTCATTCCAAAGTGTATATTGGGTTCAGACTTGGGGGCAGAAGTTCAGACACACCGTGCTCAGGAGGGA 2401 CCCAGAGCCGAGTTTCGGAGTTTGGTAAAGTTTACAGGGTAGCTTCTGAAATTAACTCAAACTTTTGACCAAATGAGTGC 2481 AGATTCTTGGATTCACTTGGTCACTGGGCTGCTGATGGTCAGCTCTGAGACAGTGGTTTGAGAGCAGGCAGAACGGTCTT 2561 GGGACTTGTTTGACTTTCCCCTCCCTGGTGGCCACTCTTTGCTCTGAAGCCCAGATTGGCAAGAGGAGCTGGTCCATTCC 2641 CCATTCATGGCACAGAGCAGTGGCAGGGCCCAGCTAGCAGGCTCTTCTGGCCTCCTTGGCCTCATTCTCTGCATAGCCCT 2721 CTGGGGATCCTGCCACCTGCCCTCTTACCCCGCCGTGGCTTATGGGGAGGAATGCATCATCTCACTTTTTTTTTTTAAGC 2801 AGATGATGGGATAACATGGACTGCTCAGTGGCCAGGTTATCAGTGGGGGGACTTAATTCTAATCTCATTCAAATGGAGAC 2881 GCCCTCTGCAAAGGCCTGGCAGGGGGAGGCACGTTTCATCTGTCAGCTCACTCCAGCTTCACAAATGTGCTGAGAGCATT 2961 ACTGTGTAGCCTTTTCTTTGAAGACACACTCGGCTCTTCTCCACAGCAAGCGTCCAGGGCAGATGGCAGAGGATCTGCCT 3041 CGGCGTCTGCAGGCGGGACCACGTCAGGGAGGGTTCCTTCATGTGTTCTCCCTGTGGGTCCTTGGACCTTTAGCCTTTTT 3121 CTTCCTTTGCAAAGGCCTTGGGGGCACTGGCTGGGAGTCAGCAAGCGAGCACTTTATATCCCTTTGAGGGAAACCCTGAT 3201 GACGCCACTGGGCCTCTTGGCGTCTGCCCTGCCCTCGCGGCTTCCCGCCGTGCCGCAGCGTGCCCACGTGCCCACGCCCC 3281 ACCAGCAGGCGGCTGTCCCGGAGGCCGTGGCCCGCTGGGACTGGCCGCCCCTCCCCAGCGTCCCAGGGCTCTGGTTCTGG 3361 AGGGCCACTTTGTCAAGGTGTTTCAGTTTTTCTTTACTTCTTTTGAAAATCTGTTTGCAAGGGGAAGGACCATTTCGTAA 3441 TGGTCTGACACAAAAGCAAGTTTGATTTTTGCAGCACTAGCAATGGACTTTGTTGTTTTTCTTTTTGATCAGAACATTCC 3521 TTCTTTACTGGTCACAGCCACGTGCTCATTCCATTCTTCTTTTTGTAGACTTTGGGCCCACGTGTTTTATGGGCATTGAT 3601 ACATATATAAATATATAGATATAAATATATATGAATATATTTTTTTAAGTTTCCTACACCTGGAGGTTGCATGGACTGTA 3681 CGACCGGCATGACTTTATATTGTATACAGATTTTGCACGCCAAACTCGGCAGCTTTGGGGAAGAAGAAAAATGCCTTTCT 3761 GTTCCCCTCTCATGACATTTGCAGATACAAAAGATGGAAATTTTTCTGTAAAACAAAACCTTGAAGGAGAGGAGGGCGGG 3841 GAAGTTTGCGTCTTATTGAACTTATTCTTAAGAAATTGTACTTTTTATTGTAAGAAAAATAAAAAGGACTACTTAAACAT 3921 TTGTCATATTAAGAAAAAAAGTTTATCTAGCACTTGTGACATACCAATAATAGAGTTTATTGTATTTATGTGGAAACAGT 4001 GTTTTAGGGAAACTACTCAGAATTCACAGTGAACTGCCTGTCTCTCTCGAGTTGATTTGGAGGAATTTTGTTTTGTTTTG 4081 TTTTGTTTGTTTCCTTTTATCTCCTTCCACGGGCCAGGCGAGCGCCGCCCGCCCTCACTGGCCTTGTGACGGTTTATTCT 4161 GATTGAGAACTGGGCGGACTCGAAAGAGTCCCCTTTTCCGCACAGCTGTGTTGACTTTTTAATTACTTTTAGGTGATGTA 4241 TGGCTAAGATTTCACTTTAAGCAGTCGTGAACTGTGCGAGCACTGTGGTTTACAATTATACTTTGCATCGAAAGGAAACC 4321 ATTTCTTCATTGTAACGAAGCTGAGCGTGTTCTTAGCTCGGCCTCACTTTGTCTCTGGCATTGATTAAAAGTCTGCTATT 4401 GAAAGAAAAAGAAAGCGAACAGTTTTTGTTTGTTTTTTTTGCCGTGTGTGCTCCATAGTGGAGGCGCTATTTTCCAATTG 4481 ATGAGAATGACAAACATATATAATCTATCTATCTATCTATCTATCTATCTATCTATACAGGGGGCTTGAACCTTACTCAC 4561 CCAAGAGCTTCTTACGGAATGTGGTAGAAAACCAAGTTGTAACGACACTGTAACCTACCTGATGCCTGTTCGCGCCCGCC 4641 GTGAGCTGCGCACTGGCCGTGGCCACCATTCACCTCTGTAATTTAATCCGTTTCTCTTGGATTGTCTGGACGTGCCCGAT 4721 GGTTCTTTCTTTTGCTCAGTGGAGTTGGAGGTTTTGTGTTTGGTTTTCTCATTCTTGTCTTGTTTTGTGTGGGTGGATTT 4801 TCACCGACCAATGATATCCTCTTCTGACGGTCACCTTCTTTCCACTTCACTGGAGTCCAGTATTCTGTACCACATCACGC 4881 AACGTGTTATCTTGTGGTGTAAATAAAGACTGCGTTACTTGCCCTCCCAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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| miRNA-target interactions (Predicted by miRanda) |
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| DRVs in gene 3'UTRs | |||||||||||||||||||||
| SNPs in gene 3'UTRs | |||||||||||||||||||||
| Experimental Support 1 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | Hep3B , HepG2 , Huh7 , SK-HEP-1 , SNU449 |
| Location of target site | 3'UTR |
| Tools used in this research | miRanda , PicTar , TargetScan |
| Original Description (Extracted from the article) |
...
"HDAC4 is a validated target of miR-1. We confirmed that HDAC4 level was indeed reduced in HCC cells expressing miR-1 (Fig. 4C and D).//The expressions of three key targets of miR-1
... - Datta J; Kutay H; Nasser MW; Nuovo GJ; Wang et al., 2008, Cancer research. |
| Article |
- Datta J; Kutay H; Nasser MW; Nuovo GJ; Wang et al. - Cancer research, 2008
MicroRNAs (miR) are a class of small ( approximately 21 nucleotide) noncoding RNAs that, in general, negatively regulate gene expression. Some miRs harboring CGIs undergo methylation-mediated silencing, a characteristic of many tumor suppressor genes. To identify such miRs in liver cancer, the miRNA expression profile was analyzed in hepatocellular carcinoma (HCC) cell lines treated with 5-azacytidine (DNA hypomethylating agent) and/or trichostatin A (histone deacetylase inhibitor). The results showed that these epigenetic drugs differentially regulate expression of a few miRs, particularly miR-1-1, in HCC cells. The CGI spanning exon 1 and intron 1 of miR-1-1 was methylated in HCC cell lines and in primary human HCCs but not in matching liver tissues. The miR-1-1 gene was hypomethylated and activated in DNMT1-/- HCT 116 cells but not in DNMT3B null cells, indicating a key role for DNMT1 in its methylation. miR-1 expression was also markedly reduced in primary human hepatocellular carcinomas compared with matching normal liver tissues. Ectopic expression of miR-1 in HCC cells inhibited cell growth and reduced replication potential and clonogenic survival. The expression of FoxP1 and MET harboring three and two miR-1 cognate sites, respectively, in their respective 3'-untranslated regions, was markedly reduced by ectopic miR-1. Up-regulation of several miR-1 targets including FoxP1, MET, and HDAC4 in primary human HCCs and down-regulation of their expression in 5-AzaC-treated HCC cells suggest their role in hepatocarcinogenesis. The inhibition of cell cycle progression and induction of apoptosis after re-expression of miR-1 are some of the mechanisms by which DNA hypomethylating agents suppress hepatocarcinoma cell growth.
LinkOut: [PMID: 18593903]
|
| Experimental Support 2 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | A549 |
| Location of target site | 3'UTR |
| Tools used in this research | Literature survey |
| Original Description (Extracted from the article) |
...
"Since HDACs have been identified as therapeutic targets in a variety of cancers
... - Nasser MW; Datta J; Nuovo G; Kutay H; et al., 2008, The Journal of biological chemistry. |
| Article |
- Nasser MW; Datta J; Nuovo G; Kutay H; et al. - The Journal of biological chemistry, 2008
Micro-RNAs are approximately 21-25-nucleotide-long noncoding RNAs that regulate gene expression primarily at the post-transcriptional level in animals. Here, we report that micro-RNA-1 (miR-1), abundant in the cardiac and smooth muscles, is expressed in the lung and is down-regulated in human primary lung cancer tissues and cell lines. In situ hybridization demonstrated localization of miR-1 in bronchial epithelial cells. The tumor suppressor C/EBPalpha, frequently suppressed in lung cancer, reactivated miR-1 expression in the lung cancer cells. Repressed miR-1 was also activated in lung cancer cells upon treatment with a histone deacetylase inhibitor. These observations led us to examine the antitumorigenic potential of miR-1 in lung cancer cells. Expression of miR-1 in nonexpressing A549 and H1299 cells reversed their tumorigenic properties, such as growth, replication potential, motility/migration, clonogenic survival, and tumor formation in nude mice. Exogenous miR-1 significantly reduced expression of oncogenic targets, such as MET, a receptor tyrosine kinase, and Pim-1, a Ser/Thr kinase, frequently up-regulated in lung cancer. Similarly, the levels of two additional targets, FoxP1, a transcription factor with oncogeneic property, and HDAC4 that represses differentiation-promoting genes, were reduced in miR-1-expressing cells. Conversely, depletion of miR-1 facilitated N417 cell growth with concomitant elevation of these targets. Further, ectopic miR-1 induced apoptosis in A549 cells in response to the potent anticancer drug doxorubicin. Enhanced activation of caspases 3 and 7, cleavage of their substrate PARP-1, and depletion of anti-apoptotic Mcl-1 contributed to the sensitivity of miR-1-expressing cells to doxorubicin. Thus, miR-1 has potential therapeutic application against lung cancers.
LinkOut: [PMID: 18818206]
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| MiRNA-Target Expression Profile | |||||||
|---|---|---|---|---|---|---|---|
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| MiRNA-Target Expression Profile (TCGA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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|
923 hsa-miR-1-3p Target Genes:
Functional analysis:
ID |
Target | Description | Validation methods |
 |
 |
|||||||
| Strong evidence | Less strong evidence | |||||||||||
 |
 |
 |
 |
 |
 |
 |
 |
|||||
| MIRT000384 | CHRNA4 | cholinergic receptor nicotinic alpha 4 subunit |  |
1 | 1 | |||||||
| MIRT000385 | MYEF2 | myelin expression factor 2 | |
|
|
3 | 3 | |||||
| MIRT000386 | RHEB | Ras homolog, mTORC1 binding | |
1 | 1 | |||||||
| MIRT000387 | RASA1 | RAS p21 protein activator 1 | |
1 | 1 | |||||||
| MIRT000389 | CDK9 | cyclin dependent kinase 9 | |
1 | 2 | |||||||
| MIRT000390 | CEBPA | CCAAT/enhancer binding protein alpha | |
1 | 1 | |||||||
| MIRT000391 | MEF2A | myocyte enhancer factor 2A | |
|
|
3 | 4 | |||||
| MIRT000392 | BCL2 | BCL2, apoptosis regulator | |
1 | 2 | |||||||
| MIRT000393 | GATA4 | GATA binding protein 4 | |
|
2 | 2 | ||||||
| MIRT000933 | HCN4 | hyperpolarization activated cyclic nucleotide gated potassium channel 4 | |
|
|
|
|
5 | 2 | |||
| MIRT001053 | HDAC4 | histone deacetylase 4 | |
|
|
|
4 | 5 | ||||
| MIRT001054 | FOXP1 | forkhead box P1 | |
|
|
|
4 | 2 | ||||
| MIRT001205 | HCN2 | hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 | |
|
|
|
4 | 2 | ||||
| MIRT001321 | YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta | |
|
2 | 1 | ||||||
| MIRT001322 | WDFY1 | WD repeat and FYVE domain containing 1 | |
|
|
3 | 2 | |||||
| MIRT001323 | UNC93B1 | unc-93 homolog B1, TLR signaling regulator | |
|
2 | 1 | ||||||
| MIRT001324 | UHRF1 | ubiquitin like with PHD and ring finger domains 1 | |
|
2 | 1 | ||||||
| MIRT001325 | TPM3 | tropomyosin 3 | |
|
|
3 | 2 | |||||
| MIRT001326 | TPM2 | tropomyosin 2 | |
|
|
3 | 2 | |||||
| MIRT001327 | TPM1 | tropomyosin 1 | |
|
|
3 | 2 | |||||
| MIRT001328 | THBS1 | thrombospondin 1 | |
|
2 | 1 | ||||||
| MIRT001329 | SYNE1 | spectrin repeat containing nuclear envelope protein 1 | |
|
2 | 1 | ||||||
| MIRT001330 | SSNA1 | SS nuclear autoantigen 1 | |
|
2 | 1 | ||||||
| MIRT001331 | SNX6 | sorting nexin 6 | |
|
2 | 1 | ||||||
| MIRT001332 | SLC25A22 | solute carrier family 25 member 22 | |
|
2 | 1 | ||||||
| MIRT001333 | SLC25A1 | solute carrier family 25 member 1 | |
|
|
3 | 2 | |||||
| MIRT001334 | SH3BGRL3 | SH3 domain binding glutamate rich protein like 3 | |
|
2 | 1 | ||||||
| MIRT001335 | SFXN1 | sideroflexin 1 | |
|
|
3 | 2 | |||||
| MIRT001336 | SEC23IP | SEC23 interacting protein | |
|
2 | 1 | ||||||
| MIRT001337 | SAC3D1 | SAC3 domain containing 1 | |
|
2 | 1 | ||||||
| MIRT001338 | RFT1 | RFT1 homolog | |
|
2 | 1 | ||||||
| MIRT001339 | PWP1 | PWP1 homolog, endonuclein | |
|
2 | 1 | ||||||
| MIRT001340 | PTPRF | protein tyrosine phosphatase, receptor type F | |
|
2 | 1 | ||||||
| MIRT001341 | PTPLB | 3-hydroxyacyl-CoA dehydratase 2 | |
|
2 | 1 | ||||||
| MIRT001342 | PTPLAD1 | 3-hydroxyacyl-CoA dehydratase 3 | |
|
2 | 1 | ||||||
| MIRT001343 | PTMA | prothymosin, alpha | |
|
|
|
|
|
|
|
8 | 11 |
| MIRT001344 | PTBP2 | polypyrimidine tract binding protein 2 | |
|
2 | 1 | ||||||
| MIRT001345 | PTBP1 | polypyrimidine tract binding protein 1 | |
|
2 | 1 | ||||||
| MIRT001346 | PRSS21 | protease, serine 21 | |
|
2 | 1 | ||||||
| MIRT001347 | PPIB | peptidylprolyl isomerase B | |
|
2 | 1 | ||||||
| MIRT001348 | POLA2 | DNA polymerase alpha 2, accessory subunit | |
|
2 | 1 | ||||||
| MIRT001350 | PICALM | phosphatidylinositol binding clathrin assembly protein | |
|
|
3 | 2 | |||||
| MIRT001351 | PDLIM7 | PDZ and LIM domain 7 | |
|
|
3 | 2 | |||||
| MIRT001352 | NRP1 | neuropilin 1 | |
|
2 | 1 | ||||||
| MIRT001353 | NOTCH2 | notch 2 | |
|
|
3 | 2 | |||||
| MIRT001354 | MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | |
|
2 | 1 | ||||||
| MIRT001355 | MRC2 | mannose receptor C type 2 | |
|
2 | 1 | ||||||
| MIRT001356 | MOV10 | Mov10 RISC complex RNA helicase | |
|
|
3 | 2 | |||||
| MIRT001357 | MET | MET proto-oncogene, receptor tyrosine kinase | |
|
|
|
|
|
6 | 7 | ||
| MIRT001358 | LRRC8A | leucine rich repeat containing 8 VRAC subunit A | |
|
|
3 | 3 | |||||
| MIRT001359 | LRP1 | LDL receptor related protein 1 | |
|
2 | 1 | ||||||
| MIRT001360 | F2 | coagulation factor II, thrombin | |
1 | 1 | |||||||
| MIRT001362 | ITGB4 | integrin subunit beta 4 | |
|
2 | 1 | ||||||
| MIRT001363 | IQGAP3 | IQ motif containing GTPase activating protein 3 | |
|
2 | 1 | ||||||
| MIRT001364 | GPD2 | glycerol-3-phosphate dehydrogenase 2 | |
|
|
|
|
|
6 | 2 | ||
| MIRT001365 | GOLGA7 | golgin A7 | |
|
2 | 1 | ||||||
| MIRT001366 | GNPNAT1 | glucosamine-phosphate N-acetyltransferase 1 | |
|
2 | 1 | ||||||
| MIRT001367 | GAK | cyclin G associated kinase | |
|
2 | 1 | ||||||
| MIRT001368 | EHMT2 | euchromatic histone lysine methyltransferase 2 | |
|
2 | 1 | ||||||
| MIRT001369 | EHMT1 | euchromatic histone lysine methyltransferase 1 | |
|
2 | 1 | ||||||
| MIRT001370 | EGFR | epidermal growth factor receptor | |
|
2 | 1 | ||||||
| MIRT001371 | DNAJB1 | DnaJ heat shock protein family (Hsp40) member B1 | |
|
2 | 1 | ||||||
| MIRT001372 | CTSC | cathepsin C | |
|
2 | 1 | ||||||
| MIRT001373 | CSRP1 | cysteine and glycine rich protein 1 | |
|
|
3 | 2 | |||||
| MIRT001374 | CPOX | coproporphyrinogen oxidase | |
|
2 | 1 | ||||||
| MIRT001375 | CORO1C | coronin 1C | |
|
|
|
|
5 | 1 | |||
| MIRT001376 | COIL | coilin | |
|
2 | 1 | ||||||
| MIRT001377 | CDCP1 | CUB domain containing protein 1 | |
|
|
3 | 2 | |||||
| MIRT001378 | CAND1 | cullin associated and neddylation dissociated 1 | |
|
|
|
4 | 3 | ||||
| MIRT001380 | BRI3BP | BRI3 binding protein | |
|
|
3 | 2 | |||||
| MIRT001381 | BCKDHB | branched chain keto acid dehydrogenase E1 subunit beta | |
|
2 | 1 | ||||||
| MIRT001382 | ATP6V0A1 | ATPase H+ transporting V0 subunit a1 | |
|
2 | 1 | ||||||
| MIRT001383 | ASH2L | ASH2 like histone lysine methyltransferase complex subunit | |
|
2 | 1 | ||||||
| MIRT001384 | ARID2 | AT-rich interaction domain 2 | |
|
2 | 1 | ||||||
| MIRT001385 | ARID1A | AT-rich interaction domain 1A | |
|
2 | 1 | ||||||
| MIRT001386 | AP3D1 | adaptor related protein complex 3 delta 1 subunit | |
|
2 | 1 | ||||||
| MIRT001387 | AP3B1 | adaptor related protein complex 3 beta 1 subunit | |
|
2 | 1 | ||||||
| MIRT001388 | ANXA2 | annexin A2 | |
|
|
|
|
5 | 3 | |||
| MIRT001389 | ANPEP | alanyl aminopeptidase, membrane | |
|
2 | 1 | ||||||
| MIRT001390 | ANP32B | acidic nuclear phosphoprotein 32 family member B | |
|
|
|
4 | 3 | ||||
| MIRT001391 | AGRN | agrin | |
|
2 | 1 | ||||||
| MIRT001392 | AGMAT | agmatinase | |
|
2 | 1 | ||||||
| MIRT001393 | ADPGK | ADP dependent glucokinase | |
|
2 | 1 | ||||||
| MIRT001394 | ABHD11 | abhydrolase domain containing 11 | |
|
2 | 1 | ||||||
| MIRT001843 | HAND2 | heart and neural crest derivatives expressed 2 | |
|
|
3 | 2 | |||||
| MIRT001844 | IGF1 | insulin like growth factor 1 | |
|
6 | 3 | ||||||
| MIRT001845 | TMSB4X | thymosin beta 4, X-linked | |
|
2 | 1 | ||||||
| MIRT001847 | SH3PXD2B | SH3 and PX domains 2B | |
1 | 2 | |||||||
| MIRT001983 | KCNJ2 | potassium voltage-gated channel subfamily J member 2 | |
|
|
|
|
5 | 5 | |||
| MIRT001984 | GJA1 | gap junction protein alpha 1 | |
|
|
|
4 | 5 | ||||
| MIRT002733 | ZNF264 | zinc finger protein 264 | |
|
2 | 2 | ||||||
| MIRT002735 | GCFC2 | GC-rich sequence DNA-binding factor 2 | |
|
2 | 1 | ||||||
| MIRT002736 | OAT | ornithine aminotransferase | |
|
|
3 | 2 | |||||
| MIRT002737 | CLCN3 | chloride voltage-gated channel 3 | |
|
2 | 1 | ||||||
| MIRT002738 | POLR2K | RNA polymerase II subunit K | |
|
2 | 1 | ||||||
| MIRT002739 | EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | |
|
2 | 2 | ||||||
| MIRT002740 | DHX15 | DEAH-box helicase 15 | |
|
|
3 | 2 | |||||
| MIRT002741 | LZTFL1 | leucine zipper transcription factor like 1 | |
|
2 | 1 | ||||||
| MIRT002742 | ARF3 | ADP ribosylation factor 3 | |
|
2 | 1 | ||||||
| MIRT002743 | OSBPL7 | oxysterol binding protein like 7 | |
|
2 | 1 | ||||||
| MIRT002746 | HIST1H3B | histone cluster 1 H3 family member b | |
|
2 | 1 | ||||||
| MIRT002747 | SH2D4A | SH2 domain containing 4A | |
|
2 | 1 | ||||||
| MIRT002748 | TRIM2 | tripartite motif containing 2 | |
|
2 | 1 | ||||||
| MIRT002749 | PLEKHG2 | pleckstrin homology and RhoGEF domain containing G2 | |
1 | 1 | |||||||
| MIRT002750 | RABL2B | RAB, member of RAS oncogene family like 2B | |
|
2 | 1 | ||||||
| MIRT002751 | XPO6 | exportin 6 | |
|
|
|
|
5 | 3 | |||
| MIRT002752 | ARCN1 | archain 1 | |
|
|
3 | 3 | |||||
| MIRT002753 | FBLN2 | fibulin 2 | |
|
2 | 1 | ||||||
| MIRT002754 | CERS2 | ceramide synthase 2 | |
|
|
|
4 | 4 | ||||
| MIRT002755 | PLEKHB2 | pleckstrin homology domain containing B2 | |
|
2 | 2 | ||||||
| MIRT002756 | POM121 | POM121 transmembrane nucleoporin | |
|
|
3 | 2 | |||||
| MIRT002758 | AXL | AXL receptor tyrosine kinase | |
|
|
3 | 2 | |||||
| MIRT002759 | POGK | pogo transposable element derived with KRAB domain | |
|
|
3 | 1 | |||||
| MIRT002760 | BLCAP | bladder cancer associated protein | |
|
2 | 2 | ||||||
| MIRT002761 | MXD4 | MAX dimerization protein 4 | |
|
2 | 1 | ||||||
| MIRT002762 | KIAA1598 | shootin 1 | |
|
2 | 1 | ||||||
| MIRT002765 | EML4 | echinoderm microtubule associated protein like 4 | |
|
2 | 1 | ||||||
| MIRT002766 | PGM2 | phosphoglucomutase 2 | |
|
|
3 | 1 | |||||
| MIRT002767 | TRAPPC3 | trafficking protein particle complex 3 | |
|
2 | 1 | ||||||
| MIRT002768 | CHSY1 | chondroitin sulfate synthase 1 | |
|
2 | 1 | ||||||
| MIRT002769 | MGC27345 | uncharacterized protein MGC27345 | |
1 | 1 | |||||||
| MIRT002771 | HIST1H3I | histone cluster 1 H3 family member i | |
1 | 1 | |||||||
| MIRT002772 | GCH1 | GTP cyclohydrolase 1 | |
|
2 | 1 | ||||||
| MIRT002776 | SERPINB5 | serpin family B member 5 | |
|
2 | 2 | ||||||
| MIRT002777 | SLC25A30 | solute carrier family 25 member 30 | |
|
2 | 2 | ||||||
| MIRT002779 | ANKRD29 | ankyrin repeat domain 29 | |
|
2 | 1 | ||||||
| MIRT002780 | TDP1 | tyrosyl-DNA phosphodiesterase 1 | |
|
2 | 1 | ||||||
| MIRT002782 | TPM4 | tropomyosin 4 | |
|
|
3 | 3 | |||||
| MIRT002783 | PREX1 | phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 | |
|
2 | 1 | ||||||
| MIRT002785 | PDCD4 | programmed cell death 4 | |
|
2 | 2 | ||||||
| MIRT002787 | RNF138 | ring finger protein 138 | |
|
|
|
4 | 4 | ||||
| MIRT002788 | TAGLN2 | transgelin 2 | |
|
|
|
|
|
6 | 7 | ||
| MIRT002789 | CHST11 | carbohydrate sulfotransferase 11 | |
|
2 | 1 | ||||||
| MIRT002792 | RABL2A | RAB, member of RAS oncogene family like 2A | |
|
2 | 1 | ||||||
| MIRT002793 | LIN7C | lin-7 homolog C, crumbs cell polarity complex component | |
|
2 | 2 | ||||||
| MIRT002794 | H3F3B | H3 histone family member 3B | |
|
|
|
4 | 6 | ||||
| MIRT002795 | SDC4 | syndecan 4 | |
|
2 | 2 | ||||||
| MIRT002797 | RABGAP1L | RAB GTPase activating protein 1 like | |
|
2 | 1 | ||||||
| MIRT002798 | CAP1 | cyclase associated actin cytoskeleton regulatory protein 1 | |
|
|
3 | 2 | |||||
| MIRT002799 | DDX5 | DEAD-box helicase 5 | |
|
|
3 | 2 | |||||
| MIRT002800 | SLC16A9 | solute carrier family 16 member 9 | |
|
2 | 2 | ||||||
| MIRT002801 | ARHGEF18 | Rho/Rac guanine nucleotide exchange factor 18 | |
|
2 | 2 | ||||||
| MIRT002802 | INPP5F | inositol polyphosphate-5-phosphatase F | |
|
2 | 2 | ||||||
| MIRT002804 | TH1L | negative elongation factor complex member C/D | |
|
|
3 | 3 | |||||
| MIRT002805 | ANKIB1 | ankyrin repeat and IBR domain containing 1 | |
|
2 | 2 | ||||||
| MIRT002806 | SERP1 | stress associated endoplasmic reticulum protein 1 | |
|
|
|
|
|
|
7 | 4 | |
| MIRT002807 | TIMP3 | TIMP metallopeptidase inhibitor 3 | |
|
2 | 2 | ||||||
| MIRT002808 | LASP1 | LIM and SH3 protein 1 | |
|
|
|
|
5 | 3 | |||
| MIRT002809 | HPS4 | HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 | |
|
2 | 2 | ||||||
| MIRT002811 | UST | uronyl 2-sulfotransferase | |
|
2 | 2 | ||||||
| MIRT002812 | RAB11FIP2 | RAB11 family interacting protein 2 | |
|
2 | 1 | ||||||
| MIRT002813 | PTMAP7 | prothymosin, alpha pseudogene 7 | |
1 | 1 | |||||||
| MIRT002814 | MMD | monocyte to macrophage differentiation associated | |
|
2 | 2 | ||||||
| MIRT002815 | NETO2 | neuropilin and tolloid like 2 | |
|
|
3 | 2 | |||||
| MIRT002816 | GNPDA2 | glucosamine-6-phosphate deaminase 2 | |
|
2 | 2 | ||||||
| MIRT002817 | ACPL2 | 2-phosphoxylose phosphatase 1 | |
|
2 | 2 | ||||||
| MIRT002819 | MTX1 | metaxin 1 | |
|
|
3 | 2 | |||||
| MIRT002820 | ADAR | adenosine deaminase, RNA specific | |
|
|
|
4 | 3 | ||||
| MIRT002823 | ARF4 | ADP ribosylation factor 4 | |
|
|
3 | 2 | |||||
| MIRT002824 | UHMK1 | U2AF homology motif kinase 1 | |
|
2 | 2 | ||||||
| MIRT002924 | KCNE1 | potassium voltage-gated channel subfamily E regulatory subunit 1 | |
|
|
|
4 | 2 | ||||
| MIRT002955 | BDNF | brain derived neurotrophic factor | |
|
2 | 1 | ||||||
| MIRT002956 | G6PD | glucose-6-phosphate dehydrogenase | |
|
|
|
|
|
6 | 5 | ||
| MIRT003203 | SOX6 | SRY-box 6 | |
|
2 | 1 | ||||||
| MIRT003524 | ATP6V1B2 | ATPase H+ transporting V1 subunit B2 | |
|
|
3 | 3 | |||||
| MIRT003525 | LARP4 | La ribonucleoprotein domain family member 4 | |
|
2 | 1 | ||||||
| MIRT003526 | CNN3 | calponin 3 | |
|
|
3 | 2 | |||||
| MIRT003762 | ARHGAP29 | Rho GTPase activating protein 29 | |
|
2 | 1 | ||||||
| MIRT003763 | CDK14 | cyclin dependent kinase 14 | |
|
2 | 1 | ||||||
| MIRT003764 | MTMR12 | myotubularin related protein 12 | |
|
2 | 2 | ||||||
| MIRT003765 | PNP | purine nucleoside phosphorylase | |
|
|
|
|
5 | 5 | |||
| MIRT003766 | CCSAP | centriole, cilia and spindle associated protein | |
|
2 | 1 | ||||||
| MIRT003767 | XPNPEP3 | X-prolyl aminopeptidase 3 | |
|
2 | 1 | ||||||
| MIRT003768 | FAM57A | family with sequence similarity 57 member A | |
|
2 | 2 | ||||||
| MIRT003769 | TNS4 | tensin 4 | |
|
2 | 1 | ||||||
| MIRT003770 | SLC44A1 | solute carrier family 44 member 1 | |
|
2 | 3 | ||||||
| MIRT003771 | IFT52 | intraflagellar transport 52 | |
|
2 | 1 | ||||||
| MIRT003772 | SRXN1 | sulfiredoxin 1 | |
|
|
3 | 2 | |||||
| MIRT003847 | RBM47 | RNA binding motif protein 47 | |
|
2 | 2 | ||||||
| MIRT003848 | C1orf56 | chromosome 1 open reading frame 56 | |
|
2 | 1 | ||||||
| MIRT003849 | C12orf49 | chromosome 12 open reading frame 49 | |
|
2 | 2 | ||||||
| MIRT003850 | IP6K2 | inositol hexakisphosphate kinase 2 | |
|
2 | 2 | ||||||
| MIRT003851 | CNOT6 | CCR4-NOT transcription complex subunit 6 | |
|
2 | 1 | ||||||
| MIRT003852 | KLHDC5 | kelch like family member 42 | |
|
2 | 2 | ||||||
| MIRT003853 | KIF2A | kinesin family member 2A | |
|
|
|
4 | 3 | ||||
| MIRT003976 | HSPD1 | heat shock protein family D (Hsp60) member 1 | |
|
2 | 5 | ||||||
| MIRT003977 | HSPA4 | heat shock protein family A (Hsp70) member 4 | |
|
2 | 3 | ||||||
| MIRT004322 | PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | |
|
|
|
4 | 3 | ||||
| MIRT004467 | CALM3 | calmodulin 3 | |
|
2 | 2 | ||||||
| MIRT004602 | PPP2R5A | protein phosphatase 2 regulatory subunit B'alpha | |
|
|
3 | 1 | |||||
| MIRT004670 | PAX3 | paired box 3 | |
|
|
|
|
|
6 | 2 | ||
| MIRT004983 | TSPAN4 | tetraspanin 4 | |
|
2 | 1 | ||||||
| MIRT005072 | SRSF9 | serine and arginine rich splicing factor 9 | |
|
|
|
|
|
|
7 | 4 | |
| MIRT005089 | TWF1 | twinfilin actin binding protein 1 | |
|
|
|
|
|
6 | 3 | ||
| MIRT005273 | ZNF384 | zinc finger protein 384 | |
|
2 | 1 | ||||||
| MIRT005274 | SNAPIN | SNAP associated protein | |
|
2 | 1 | ||||||
| MIRT005275 | NSUN4 | NOP2/Sun RNA methyltransferase family member 4 | |
|
2 | 1 | ||||||
| MIRT005277 | WDR11 | WD repeat domain 11 | |
|
2 | 1 | ||||||
| MIRT005278 | MON2 | MON2 homolog, regulator of endosome-to-Golgi trafficking | |
|
2 | 1 | ||||||
| MIRT005279 | TMX1 | thioredoxin related transmembrane protein 1 | |
|
2 | 1 | ||||||
| MIRT005280 | RNF213 | ring finger protein 213 | |
|
2 | 1 | ||||||
| MIRT005281 | FERMT2 | fermitin family member 2 | |
|
2 | 1 | ||||||
| MIRT005282 | HNRNPU | heterogeneous nuclear ribonucleoprotein U | |
|
2 | 1 | ||||||
| MIRT005283 | ARMC10 | armadillo repeat containing 10 | |
|
2 | 1 | ||||||
| MIRT005284 | PSMG1 | proteasome assembly chaperone 1 | |
|
2 | 1 | ||||||
| MIRT005285 | RRBP1 | ribosome binding protein 1 | |
|
2 | 1 | ||||||
| MIRT005439 | IRF2BPL | interferon regulatory factor 2 binding protein like | |
|
2 | 1 | ||||||
| MIRT005539 | TWF2 | twinfilin actin binding protein 2 | |
|
|
|
4 | 1 | ||||
| MIRT005904 | CALM2 | calmodulin 2 | |
|
|
|
4 | 4 | ||||
| MIRT005905 | GATA6 | GATA binding protein 6 | |
1 | 1 | |||||||
| MIRT006132 | FN1 | fibronectin 1 | |
|
|
|
4 | 2 | ||||
| MIRT006550 | NOTCH3 | notch 3 | |
|
|
|
4 | 3 | ||||
| MIRT006819 | SLC8A1 | solute carrier family 8 member A1 | |
|
4 | 2 | ||||||
| MIRT006855 | EDN1 | endothelin 1 | |
5 | 6 | |||||||
| MIRT007205 | PRKCE | protein kinase C epsilon | |
1 | 1 | |||||||
| MIRT007213 | FABP3 | fatty acid binding protein 3 | |
|
|
3 | 1 | |||||
| MIRT007214 | SNAI2 | snail family transcriptional repressor 2 | |
|
|
3 | 2 | |||||
| MIRT007222 | SOX9 | SRY-box 9 | |
1 | 1 | |||||||
| MIRT023484 | CDC42BPB | CDC42 binding protein kinase beta | |
1 | 1 | |||||||
| MIRT023485 | SRRM1 | serine and arginine repetitive matrix 1 | |
1 | 1 | |||||||
| MIRT023486 | CD44 | CD44 molecule (Indian blood group) | |
1 | 1 | |||||||
| MIRT023487 | SPRY2 | sprouty RTK signaling antagonist 2 | |
1 | 1 | |||||||
| MIRT023488 | MECR | mitochondrial trans-2-enoyl-CoA reductase | |
1 | 1 | |||||||
| MIRT023489 | CUL4B | cullin 4B | |
1 | 1 | |||||||
| MIRT023490 | RAB34 | RAB34, member RAS oncogene family | |
1 | 1 | |||||||
| MIRT023491 | SOX5 | SRY-box 5 | |
1 | 1 | |||||||
| MIRT023492 | YTHDC1 | YTH domain containing 1 | |
1 | 1 | |||||||
| MIRT023493 | DGKH | diacylglycerol kinase eta | |
1 | 1 | |||||||
| MIRT023494 | FGFR2 | fibroblast growth factor receptor 2 | |
1 | 1 | |||||||
| MIRT023495 | OCIAD2 | OCIA domain containing 2 | |
1 | 1 | |||||||
| MIRT023496 | SYMPK | symplekin | |
1 | 1 | |||||||
| MIRT023497 | LIPC | lipase C, hepatic type | |
|||||||||