ID	Duplex structure	Position	Score	MFE
1	miRNA 3' ugUGGCUCCUCGGGUAGUACUa 5' ||: || | : ||||||| Target 5' tgACT-AGAAATAGATCATGAt 3'	167 - 187	147.00	-7.70
2	miRNA 3' uguggcuccucGGGUAGUACUa 5' |||||||| | Target 5' ttgtcatagttCCCATCATAAa 3'	48 - 69	123.00	-10.52
3	miRNA 3' ugugGCUCCUCG-GGUAGUACUa 5' ||| ||: |||:|||: Target 5' agtgCGA-TAGTGACATTATGGa 3'	1 - 22	117.00	-10.90

Mutant ID	Mutant Position	Mutant Source
4885	182	ClinVar
COSN30654894	6	COSMIC
COSN30104286	8	COSMIC
COSN30106013	13	COSMIC
COSN19669445	22	COSMIC
COSN30188535	34	COSMIC
COSN30472020	47	COSMIC
COSN30488253	61	COSMIC
COSN30485319	82	COSMIC
COSN28792140	83	COSMIC
COSN30123348	87	COSMIC
COSN31510740	88	COSMIC
COSN30516930	119	COSMIC
COSN31605197	136	COSMIC
COSN30169175	137	COSMIC
COSN28840510	156	COSMIC
COSN30130157	164	COSMIC
COSN30111034	168	COSMIC
COSN27821382	419	COSMIC
COSN27306790	457	COSMIC

Mutant ID	Mutant Position	Mutant Source
rs749890928	2	dbSNP
rs780521897	3	dbSNP
rs372623598	5	dbSNP
rs767969554	6	dbSNP
rs369979222	8	dbSNP
rs774471972	10	dbSNP
rs774693591	11	dbSNP
rs771137602	13	dbSNP
rs575400716	15	dbSNP
rs773213151	17	dbSNP
rs1436554665	18	dbSNP
rs769791216	21	dbSNP
rs377266598	26	dbSNP
rs764711524	30	dbSNP
rs984994210	30	dbSNP
rs1296865111	32	dbSNP
rs1228798420	33	dbSNP
rs113126203	34	dbSNP
rs1017087794	37	dbSNP
rs768410520	38	dbSNP
rs1198587159	39	dbSNP
rs1446860626	40	dbSNP
rs746767850	42	dbSNP
rs369523536	47	dbSNP
rs1004331933	48	dbSNP
rs758002395	50	dbSNP
rs1438376175	51	dbSNP
rs975773082	52	dbSNP
rs965682514	53	dbSNP
rs1378426860	64	dbSNP
rs1465724434	66	dbSNP
rs1431802905	81	dbSNP
rs1721100	83	dbSNP
rs534476986	86	dbSNP
rs1396779442	87	dbSNP
rs140595599	88	dbSNP
rs998417008	95	dbSNP
rs182573765	96	dbSNP
rs1033200361	97	dbSNP
rs1330212653	103	dbSNP
rs1269622295	104	dbSNP
rs1230585180	105	dbSNP
rs6982917	111	dbSNP
rs569516194	113	dbSNP
rs1318375427	114	dbSNP
rs112602726	120	dbSNP
rs1045775155	126	dbSNP
rs373460171	141	dbSNP
rs1256091326	143	dbSNP
rs572374220	146	dbSNP
rs904598532	147	dbSNP
rs142106513	148	dbSNP
rs566436899	150	dbSNP
rs116309944	154	dbSNP
rs1268125515	154	dbSNP
rs937947933	154	dbSNP
rs147590629	155	dbSNP
rs113374862	156	dbSNP
rs564045462	161	dbSNP
rs1170334580	164	dbSNP
rs746261060	164	dbSNP
rs2640901	165	dbSNP
rs779979768	166	dbSNP
rs530611016	169	dbSNP
rs1309906269	171	dbSNP
rs1302812822	175	dbSNP
rs1223992114	176	dbSNP
rs1349813966	179	dbSNP
rs12720208	182	dbSNP
rs533487160	183	dbSNP
rs1217791933	184	dbSNP
rs574070314	185	dbSNP
rs769148271	186	dbSNP
rs951641387	187	dbSNP
rs975825506	190	dbSNP
rs1302463152	197	dbSNP
rs965734689	199	dbSNP
rs1488739983	207	dbSNP
rs1029805434	214	dbSNP
rs560503402	218	dbSNP
rs998865931	222	dbSNP
rs751701947	223	dbSNP
rs900067949	227	dbSNP
rs1368353077	232	dbSNP
rs1455945343	239	dbSNP
rs1185043526	240	dbSNP
rs1370450548	241	dbSNP
rs17515351	243	dbSNP
rs1255945759	246	dbSNP
rs1000193361	247	dbSNP
rs1357090599	259	dbSNP
rs1199490603	261	dbSNP
rs578238179	266	dbSNP
rs904484059	268	dbSNP
rs999003744	285	dbSNP
rs1264400384	286	dbSNP
rs1041831813	287	dbSNP
rs1216126034	291	dbSNP
rs946124140	291	dbSNP
rs1024379139	295	dbSNP
rs1182745619	309	dbSNP
rs1256073881	311	dbSNP
rs1014302079	317	dbSNP
rs895657448	320	dbSNP
rs77259875	322	dbSNP
rs1418750432	335	dbSNP
rs937285731	337	dbSNP
rs1376842048	344	dbSNP
rs927226719	345	dbSNP
rs1302042922	355	dbSNP
rs1376964257	359	dbSNP
rs1037370828	362	dbSNP
rs1393046229	363	dbSNP
rs1005934099	376	dbSNP
rs1354541180	381	dbSNP
rs887727487	385	dbSNP
rs1404623289	388	dbSNP
rs1049431393	394	dbSNP
rs1211345514	395	dbSNP
rs1337715762	397	dbSNP
rs1482590993	400	dbSNP
rs1456760397	402	dbSNP
rs538577421	407	dbSNP
rs1239273198	409	dbSNP
rs575888899	410	dbSNP
rs1176168884	411	dbSNP
rs192962979	411	dbSNP
rs772551583	412	dbSNP
rs535500971	416	dbSNP
rs10089759	425	dbSNP
rs746294164	432	dbSNP
rs779217367	434	dbSNP
rs1357182462	435	dbSNP
rs922818507	439	dbSNP
rs1331986908	442	dbSNP
rs977040898	446	dbSNP
rs1721082	449	dbSNP
rs1307171925	453	dbSNP
rs1203971295	454	dbSNP
rs1464032347	457	dbSNP
rs1278403839	464	dbSNP
rs1018452811	467	dbSNP
rs957243047	468	dbSNP
rs1200856945	469	dbSNP
rs750613452	469	dbSNP
rs1000399884	470	dbSNP
rs1457709388	471	dbSNP
rs539061752	474	dbSNP
rs967570638	477	dbSNP
rs1351326905	480	dbSNP
rs1264566528	484	dbSNP
rs1242334035	486	dbSNP
rs1024432862	490	dbSNP
rs1342098813	492	dbSNP
rs1020404581	495	dbSNP
rs1463987728	506	dbSNP
rs1326987907	508	dbSNP
rs1010628933	513	dbSNP
rs1437227679	514	dbSNP
rs1274504433	515	dbSNP
rs1434694082	522	dbSNP
rs1363067444	525	dbSNP
rs1220852245	526	dbSNP
rs145080533	529	dbSNP
rs1317890294	533	dbSNP
rs550446125	536	dbSNP
rs958828256	538	dbSNP
rs895829282	541	dbSNP
rs1186951473	542	dbSNP
rs1401741444	543	dbSNP
rs533758255	544	dbSNP
rs1001460232	547	dbSNP
rs1194188485	552	dbSNP
rs1422627055	553	dbSNP
rs905825164	555	dbSNP
rs1164959091	558	dbSNP
rs187908938	560	dbSNP
rs1406037212	561	dbSNP
rs1322893471	571	dbSNP
rs1037487140	577	dbSNP
rs183080996	582	dbSNP
rs1402057926	592	dbSNP
rs993421043	595	dbSNP
rs17550374	598	dbSNP
rs577732279	600	dbSNP
rs1286482864	610	dbSNP
rs1183789918	611	dbSNP
rs190519711	613	dbSNP
rs932948620	614	dbSNP
rs1194701583	615	dbSNP
rs1216841620	618	dbSNP
rs922966559	625	dbSNP
rs974854180	628	dbSNP
rs964320893	631	dbSNP
rs1050596798	636	dbSNP
rs17550381	640	dbSNP
rs911505363	643	dbSNP
rs114699511	644	dbSNP
rs1472422846	647	dbSNP
rs968892541	648	dbSNP
rs1020350888	650	dbSNP
rs1421548791	652	dbSNP
rs977018413	654	dbSNP
rs76141694	657	dbSNP
rs1361289940	658	dbSNP
rs1336556644	662	dbSNP
rs56198250	664	dbSNP
rs1341649633	668	dbSNP
rs1447913288	676	dbSNP
rs1292263036	679	dbSNP
rs917473028	685	dbSNP
rs568573477	688	dbSNP
rs1284881925	693	dbSNP
rs1350964250	693	dbSNP
rs1227889082	698	dbSNP
rs1340324108	708	dbSNP
rs1185371453	713	dbSNP
rs1239880406	714	dbSNP
rs1441643174	719	dbSNP
rs992983677	723	dbSNP
rs959106618	725	dbSNP
rs960272040	726	dbSNP
rs752810859	728	dbSNP
rs550273218	729	dbSNP
rs1006040234	736	dbSNP
rs1322122243	747	dbSNP
rs1389078010	753	dbSNP
rs952791862	761	dbSNP
rs1307890282	763	dbSNP
rs1366542410	765	dbSNP
rs10888125	771	dbSNP
rs1344064079	773	dbSNP
rs1198457112	779	dbSNP
rs994145288	782	dbSNP
rs1458157845	783	dbSNP
rs897775307	792	dbSNP
rs1417597853	793	dbSNP
rs1001973439	796	dbSNP
rs560385273	806	dbSNP
rs1008771839	807	dbSNP
rs17550395	808	dbSNP
rs1475441669	810	dbSNP
rs935753719	811	dbSNP
rs1196610957	815	dbSNP
rs1393733546	820	dbSNP
rs1323824015	823	dbSNP
rs17515365	825	dbSNP
rs78278697	825	dbSNP
rs1041380924	834	dbSNP
rs1005983306	835	dbSNP
rs778771467	838	dbSNP
rs1047897576	847	dbSNP
rs933083297	848	dbSNP
rs1204184416	850	dbSNP
rs993039428	852	dbSNP
rs901623860	858	dbSNP
rs1211650442	860	dbSNP
rs1268322983	864	dbSNP
rs1451246927	865	dbSNP
rs1275367989	872	dbSNP
rs927462097	873	dbSNP
rs1478331660	874	dbSNP
rs1170625308	877	dbSNP
rs984267837	878	dbSNP
rs1215431366	879	dbSNP
rs1038684152	880	dbSNP
rs943039897	883	dbSNP
rs1163332028	884	dbSNP
rs1344361614	885	dbSNP
rs1273189020	891	dbSNP
rs1613372	892	dbSNP

- American journal of human genetics, 2008

Parkinson disease (PD) is a common neurodegenerative disorder caused by environmental and genetic factors. We have previously shown linkage of PD to chromosome 8p. Subsequently, fibroblast growth factor 20 (FGF20) at 8p21.3-22 was identified as a risk factor in several association studies. To identify the risk-conferring polymorphism in FGF20, we performed genetic and functional analysis of single-nucleotide polymorphisms within the gene. In a sample of 729 nuclear families with 1089 affected and 1165 unaffected individuals, the strongest evidence of association came from rs12720208 in the 3' untranslated region of FGF20. We show in several functional assays that the risk allele for rs12720208 disrupts a binding site for microRNA-433, increasing translation of FGF20 in vitro and in vivo. In a cell-based system and in PD brains, this increase in translation of FGF20 is correlated with increased alpha-synuclein expression, which has previously been shown to cause PD through both overexpression and point mutations. We suggest a novel mechanism of action for PD risk in which the modulation of the susceptibility gene's translation by common variations interfere with the regulation mechanisms of microRNA. We propose this is likely to be a common mechanism of genetic modulation of individual susceptibility to complex disease.