miRTarBase - #MIRT002576


—
pre-miRNA Information
pre-miRNA hsa-mir-124-1   
Genomic Coordinates chr8: 9903388 - 9903472
Description Homo sapiens miR-124-1 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-2   
Genomic Coordinates chr8: 64379149 - 64379257
Description Homo sapiens miR-124-2 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-3   
Genomic Coordinates chr20: 63178500 - 63178586
Description Homo sapiens miR-124-3 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-124-3p
Sequence 53| UAAGGCACGCGGUGAAUGCC |72
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 22 8 - 9903399 17604727 MiREDiBase
A-to-I 22 8 + 64379231 17604727 MiREDiBase
A-to-I 22 20 + 63178573 17604727 MiREDiBase
C-to-U 19 8 - 9903402 20591823 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs34059726 4 dbSNP
rs1287398108 8 dbSNP
rs1482188536 11 dbSNP
rs759034202 11 dbSNP
rs1364752547 12 dbSNP
rs764861083 13 dbSNP
rs749909250 18 dbSNP
rs759045572 19 dbSNP
rs753437646 20 dbSNP
rs1256263272 21 dbSNP
miRNA Oxidation Modification
Oxidation Position Sequence (5'-3') Target Gene Validation Method PMID
4 UAAGGCACGCGGUGAAUGCC MEOX2; EGFR; IGF2BP3; BCAT1 Luciferase reporter assay 37696949
4 UAAGGCACGCGGUGAAUGCC not mentioned qPCR 38912549
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Increase Plasma Polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Peripheral blood mononuclear cell Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol SLC17A5   
Synonyms AST, ISSD, NSD, SD, SIALIN, SIASD, SLD
Description solute carrier family 17 member 5
Transcript NM_012434   
Expression
Putative miRNA Targets on SLC17A5
3'UTR of SLC17A5
(miRNA target sites are highlighted)		 
>SLC17A5|NM_012434|3'UTR
   1 AGGAACCAATAAATAATCCTGCCTCTATTAATGTATTTTTATTTATCATGTAACCTCAAAGTGCCTTCTGTATTGTGTAA
  81 GCATTCTATGTCTTTTTTTAATTGTACTTGTATTAGATTTTTAAGGCCTATAATCATGAAATATCACTAGTTGCCAGAAT
 161 AATAAAATGAACTGTGTTTAATTATGAATAATATGTAAGCTAGGACTTCTACTTTAGGTTCACATACCTGCCTGCTAGTC
 241 GGGCAACATGAAGTAGGACAGTTCTGTTGATTTTTTAGGGCCATACTAAAGGGAATGAGCTGAAACAGACCTCCTGATAC
 321 CTTTGCTTAATTAAACTAGATGATAATTCTCAGGTACTGATAAACACCTGTTGTTGTTCACTTTCCTCATAAAAATTGTC
 401 AGCTCTCTCTGACACTTAGACCTCAAACTTTAGCAT