miRTarBase - #MIRT003968


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pre-miRNA Information
pre-miRNA hsa-mir-26a-1   
Genomic Coordinates chr3: 37969404 - 37969480
Synonyms MIR26A, MIRN26A1, MIR26A1
Description Homo sapiens miR-26a-1 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-26a-2   
Genomic Coordinates chr12: 57824609 - 57824692
Synonyms MIRN26A2, MIR26A2
Description Homo sapiens miR-26a-2 stem-loop
Comment miR-26a was cloned from HeLa cells .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-26a-5p
Sequence 10| UUCAAGUAAUCCAGGAUAGGCU |31
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
C-to-U 21 3 + 37969433 17604727 MiREDiBase
C-to-U 21 12 - 57824659 17604727 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30516844 7 COSMIC
COSN30543820 11 COSMIC
COSN30447912 11 COSMIC
COSN31502139 13 COSMIC
COSN31591664 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1323067579 3 dbSNP
rs1315291543 9 dbSNP
rs1249227702 12 dbSNP
rs1348933092 17 dbSNP
rs1012142515 17 dbSNP
rs1445643611 18 dbSNP
rs756293180 19 dbSNP
rs765258989 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B52VKB miR-26a Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Increase Plasma Quantitative real-time PCR
BI82DS miR-26a-5p Predictive Biomarker (PRD) Clinical/Experimental Data Expression High Peripheral blood Quantitative real-time PCR
Gene Information
Gene Symbol MYC   
Synonyms MRTL, MYCC, bHLHe39, c-Myc
Description MYC proto-oncogene, bHLH transcription factor
Transcript NM_002467   
Expression
Putative miRNA Targets on MYC
3'UTR of MYC
(miRNA target sites are highlighted)		 
>MYC|NM_002467|3'UTR
   1 GGAAAAGTAAGGAAAACGATTCCTTCTAACAGAAATGTCCTGAGCAATCACCTATGAACTTGTTTCAAATGCATGATCAA
  81 ATGCAACCTCACAACCTTGGCTGAGTCTTGAGACTGAAAGATTTAGCCATAATGTAAACTGCCTCAAATTGGACTTTGGG
 161 CATAAAAGAACTTTTTTATGCTTACCATCTTTTTTTTTTCTTTAACAGATTTGTATTTAAGAATTGTTTTTAAAAAATTT
 241 TAAGATTTACACAATGTTTCTCTGTAAATATTGCCATTAAATGTAAATAACTTTAATAAAACGTTTATAGCAGTTACACA
 321 GAATTTCAATCCTAGTATATAGTACCTAGTATTATAGGTACTATAAACCCTAATTTTTTTTATTTAAGTACATTTTGCTT
 401 TTTAAAGTTGATTTTTTTCTATTGTTTTTAGAAAAAATAAAATAACTGGCAAATATATCATTGAGCCAAATCTTAAAAAA
 481 AAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucGGAUA---GGAC----CUAAUGAACUu 5'
            |||||   |:||     | |:| ||| 
Target 5' caCCTATGAACTTGTTTCAAATGCATGAt 3'
 49 - 77 106.00 -6.60
2 
miRNA  3' ucgGAUAGGAC---CUAAUGAACUu 5'
             | | |:||   || | ||||| 
Target 5' tcaCAACCTTGGCTGAGT-CTTGAg 3'
 89 - 112 103.00 -11.20
3 
miRNA  3' ucGGA-UAGGACCUAAUGAAcuu 5'
            ||| |  :|||   ||||   
Target 5' tgCCTCAAATTGG---ACTTtgg 3'
 140 - 159 84.00 -12.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN14324859 18 COSMIC
COSN31491901 25 COSMIC
COSN31573866 36 COSMIC
COSN30461269 41 COSMIC
COSN15315257 51 COSMIC
COSN30479950 53 COSMIC
COSN30646181 68 COSMIC
COSN9597076 69 COSMIC
COSN30496495 79 COSMIC
COSN31530358 79 COSMIC
COSN5674198 107 COSMIC
COSN30452818 115 COSMIC
COSN9255250 126 COSMIC
COSN9597077 129 COSMIC
COSN9597078 133 COSMIC
COSN18733201 179 COSMIC
COSN15664850 200 COSMIC
COSN31602668 230 COSMIC
COSN31772579 238 COSMIC
COSN30175029 293 COSMIC
COSN1359443 320 COSMIC
COSN14898034 357 COSMIC
COSN28763683 387 COSMIC
COSN31772580 450 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1362443865 2 dbSNP
rs779751378 6 dbSNP
rs200447778 10 dbSNP
rs1331275161 11 dbSNP
rs1452207357 13 dbSNP
rs768701719 16 dbSNP
rs373561075 18 dbSNP
rs367692900 19 dbSNP
rs1438303994 21 dbSNP
rs1281624150 29 dbSNP
rs931069152 30 dbSNP
rs774015583 31 dbSNP
rs747913772 33 dbSNP
rs181048497 41 dbSNP
rs1353515183 44 dbSNP
rs35524866 45 dbSNP
rs546100354 45 dbSNP
rs949093702 46 dbSNP
rs200570465 47 dbSNP
rs907487353 49 dbSNP
rs759911200 50 dbSNP
rs2070583 51 dbSNP
rs576408843 52 dbSNP
rs1245476064 53 dbSNP
rs1003352425 54 dbSNP
rs1031845666 55 dbSNP
rs893273346 56 dbSNP
rs1190366265 57 dbSNP
rs1388324174 58 dbSNP
rs1474451314 59 dbSNP
rs760393718 69 dbSNP
rs1391577072 91 dbSNP
rs149534345 95 dbSNP
rs1028803920 97 dbSNP
rs1363132641 106 dbSNP
rs544605712 107 dbSNP
rs14607 110 dbSNP
rs1006494666 111 dbSNP
rs1436355649 115 dbSNP
rs185650723 128 dbSNP
rs4645970 130 dbSNP
rs1427861623 133 dbSNP
rs987235223 139 dbSNP
rs1226030225 143 dbSNP
rs542316783 144 dbSNP
rs1019568567 160 dbSNP
rs1192842372 163 dbSNP
rs961317581 169 dbSNP
rs1266830942 173 dbSNP
rs975108386 179 dbSNP
rs1483468160 183 dbSNP
rs1028404221 186 dbSNP
rs1307281064 190 dbSNP
rs371119850 190 dbSNP
rs986942649 190 dbSNP
rs924487690 201 dbSNP
rs560444505 205 dbSNP
rs1301946221 231 dbSNP
rs1371960357 232 dbSNP
rs934456533 232 dbSNP
rs990034221 233 dbSNP
rs753508752 237 dbSNP
rs1461351266 238 dbSNP
rs972586894 239 dbSNP
rs919772233 252 dbSNP
rs143895359 254 dbSNP
rs1210404336 255 dbSNP
rs931114049 256 dbSNP
rs990648738 257 dbSNP
rs1246093632 259 dbSNP
rs1472952830 266 dbSNP
rs1254330747 277 dbSNP
rs1427804412 290 dbSNP
rs1188205475 291 dbSNP
rs907186988 303 dbSNP
rs552525496 304 dbSNP
rs1321949168 313 dbSNP
rs564425416 321 dbSNP
rs949155742 322 dbSNP
rs190322311 338 dbSNP
rs778430083 339 dbSNP
rs923561358 344 dbSNP
rs1304464370 360 dbSNP
rs934906579 361 dbSNP
rs1053336677 362 dbSNP
rs752036530 364 dbSNP
rs1163039403 368 dbSNP
rs1468183786 370 dbSNP
rs1016431498 374 dbSNP
rs886607980 374 dbSNP
rs893327404 374 dbSNP
rs1179956021 387 dbSNP
rs900793735 387 dbSNP
rs550160158 392 dbSNP
rs1049908801 398 dbSNP
rs1185749197 399 dbSNP
rs889904780 399 dbSNP
rs568518631 408 dbSNP
rs1330660879 412 dbSNP
rs562624244 412 dbSNP
rs955185283 412 dbSNP
rs1258379502 414 dbSNP
rs535929859 420 dbSNP
rs1019578422 421 dbSNP
rs529405092 426 dbSNP
rs1031804737 432 dbSNP
rs1314420816 432 dbSNP
rs1382114180 432 dbSNP
rs1381732668 434 dbSNP
rs755565767 444 dbSNP
rs1341676481 448 dbSNP
rs1242050026 450 dbSNP
rs1156821729 451 dbSNP
rs994062577 451 dbSNP
rs955782808 458 dbSNP
rs989981761 460 dbSNP
rs1359749415 461 dbSNP
rs914389805 462 dbSNP
rs1242892491 470 dbSNP
rs1189793239 486 dbSNP
rs781405135 487 dbSNP
rs1026880159 491 dbSNP
rs1229881592 496 dbSNP
rs548284320 497 dbSNP
rs1243296011 503 dbSNP
rs1266883844 503 dbSNP
rs991092766 507 dbSNP
rs916415070 508 dbSNP
rs1258251930 510 dbSNP
rs1437194341 511 dbSNP
rs928673770 525 dbSNP
rs1381787358 526 dbSNP
rs970886207 537 dbSNP
rs566471603 543 dbSNP
rs923613724 544 dbSNP
rs148188362 546 dbSNP
rs1037895418 547 dbSNP
rs1371921454 559 dbSNP
rs34682115 560 dbSNP
rs1473013197 565 dbSNP
rs1193066431 573 dbSNP
rs541510321 575 dbSNP
rs1270355743 580 dbSNP
rs1362352940 580 dbSNP
rs1219836396 582 dbSNP
rs1490065537 588 dbSNP
rs1275106389 590 dbSNP
rs914837117 591 dbSNP
rs996455670 593 dbSNP
rs1030961340 596 dbSNP
rs1269564322 605 dbSNP
rs890805369 608 dbSNP
rs1331774956 609 dbSNP
rs1173655072 616 dbSNP
rs1304985662 625 dbSNP
rs947656300 634 dbSNP
rs558826267 637 dbSNP
rs1365254438 648 dbSNP
rs889924017 650 dbSNP
rs778102478 654 dbSNP
rs376385237 658 dbSNP
rs1394760437 660 dbSNP
rs955814959 661 dbSNP
rs1011269784 662 dbSNP
rs1021428607 663 dbSNP
rs969843417 665 dbSNP
rs749564337 672 dbSNP
rs560392947 678 dbSNP
rs928506151 679 dbSNP
rs1411208748 682 dbSNP
rs1435911709 685 dbSNP
rs1286086243 687 dbSNP
rs1041083667 693 dbSNP
rs141503199 702 dbSNP
rs983896024 703 dbSNP
rs907855814 711 dbSNP
rs1221837881 717 dbSNP
rs994155868 719 dbSNP
rs1280413062 723 dbSNP
rs1037759950 730 dbSNP
rs1210102346 731 dbSNP
rs1328524787 733 dbSNP
rs1026932841 735 dbSNP
rs181649764 742 dbSNP
rs1409016604 752 dbSNP
rs1174895022 753 dbSNP
rs186781003 754 dbSNP
rs1412032870 755 dbSNP
rs574790380 757 dbSNP
rs1483423768 758 dbSNP
rs932109332 768 dbSNP
rs1012126869 779 dbSNP
rs774632440 781 dbSNP
rs1051930848 789 dbSNP
rs1462486047 790 dbSNP
rs1023896394 795 dbSNP
rs890742830 798 dbSNP
rs1322949403 799 dbSNP
rs572241574 807 dbSNP
rs1284998838 820 dbSNP
rs541930040 821 dbSNP
rs1225690294 823 dbSNP
rs999765993 827 dbSNP
rs970557438 836 dbSNP
rs1248752892 840 dbSNP
rs981876945 842 dbSNP
rs923710357 843 dbSNP
rs1453917788 844 dbSNP
rs192089690 849 dbSNP
rs1335376628 852 dbSNP
rs989180728 855 dbSNP
rs1052750043 862 dbSNP
rs1160564541 871 dbSNP
rs1398605629 876 dbSNP
rs1200087225 880 dbSNP
rs1163449352 885 dbSNP
rs906824192 886 dbSNP
rs369999379 888 dbSNP
rs1182946577 889 dbSNP
rs1021292790 893 dbSNP
rs1173571178 894 dbSNP
rs1242791369 896 dbSNP
rs1218110368 898 dbSNP
rs554217507 900 dbSNP
rs1001806624 901 dbSNP
rs1431165657 905 dbSNP
rs1296091102 909 dbSNP
rs1313317196 914 dbSNP
rs183850214 924 dbSNP
rs944231870 925 dbSNP
rs1303073506 927 dbSNP
rs983373244 928 dbSNP
rs1368554361 929 dbSNP
rs1303407544 931 dbSNP
rs545977969 938 dbSNP
rs1383161009 944 dbSNP
rs4645971 949 dbSNP
rs775305295 950 dbSNP
rs1421646129 957 dbSNP
rs1184673670 959 dbSNP
rs1484961887 960 dbSNP
rs1241542155 962 dbSNP
rs963350284 963 dbSNP
rs186425113 967 dbSNP
rs543718581 972 dbSNP
rs1245769786 974 dbSNP
rs1207461493 999 dbSNP
rs1249803703 1001 dbSNP
rs1213278724 1003 dbSNP
rs932082900 1005 dbSNP
rs562110890 1011 dbSNP
rs888419381 1012 dbSNP
rs1210697326 1026 dbSNP
rs1269835976 1028 dbSNP
rs1052388785 1029 dbSNP
rs529667999 1031 dbSNP
rs1391398654 1033 dbSNP
rs1450761255 1035 dbSNP
rs1356038076 1038 dbSNP
rs1168263489 1045 dbSNP
rs1427808502 1046 dbSNP
rs544395121 1052 dbSNP
rs139159192 1053 dbSNP
rs765476985 1058 dbSNP
rs1222000513 1065 dbSNP
rs906426058 1065 dbSNP
rs1003407494 1070 dbSNP
rs566549822 1075 dbSNP
rs527438788 1076 dbSNP
rs1307368804 1084 dbSNP
rs1298233794 1088 dbSNP
rs143798928 1096 dbSNP
rs764712948 1098 dbSNP
rs773551317 1104 dbSNP
rs1212759760 1107 dbSNP
rs4645972 1108 dbSNP
rs189649721 1109 dbSNP
rs1391560030 1122 dbSNP
rs986180555 1124 dbSNP
rs1296167448 1130 dbSNP
rs1461428658 1137 dbSNP
rs146363336 1144 dbSNP
rs1406808798 1147 dbSNP
rs1245727201 1156 dbSNP
rs911505936 1162 dbSNP
rs1467414589 1167 dbSNP
rs1198467607 1178 dbSNP
rs944284119 1185 dbSNP
rs973440966 1190 dbSNP
rs1175907738 1192 dbSNP
rs116768771 1193 dbSNP
rs953617444 1195 dbSNP
rs1320830991 1199 dbSNP
rs182295576 1209 dbSNP
rs912067388 1221 dbSNP
rs930070349 1223 dbSNP
rs1418082464 1224 dbSNP
rs1048444140 1226 dbSNP
rs186907577 1229 dbSNP
rs915529914 1232 dbSNP
rs1166451335 1241 dbSNP
rs1450311714 1245 dbSNP
rs768009219 1248 dbSNP
rs878955999 1254 dbSNP
rs572499713 1256 dbSNP
rs71520682 1287 dbSNP
rs1460697118 1288 dbSNP
rs906483805 1292 dbSNP
rs1042729184 1308 dbSNP
rs1003460090 1312 dbSNP
rs905515204 1317 dbSNP
rs557892493 1331 dbSNP
rs549762957 1348 dbSNP
rs1390605046 1349 dbSNP
rs1428475908 1350 dbSNP
rs1439524655 1352 dbSNP
rs892272524 1354 dbSNP
rs1185999262 1356 dbSNP
rs4645973 1360 dbSNP
rs778333249 1362 dbSNP
rs1258625748 1364 dbSNP
rs370221716 1364 dbSNP
rs1022023630 1365 dbSNP
rs1359932909 1367 dbSNP
rs1316814165 1375 dbSNP
rs953234060 1376 dbSNP
rs1382018014 1383 dbSNP
rs1295318461 1384 dbSNP
rs749509425 1396 dbSNP
rs985847052 1405 dbSNP
rs757623398 1413 dbSNP
rs139430896 1417 dbSNP
rs562389011 1418 dbSNP
rs529598316 1420 dbSNP
rs1214201921 1421 dbSNP
rs745907253 1424 dbSNP
rs1385900463 1426 dbSNP
rs541802702 1427 dbSNP
rs559893073 1428 dbSNP
rs1029419944 1433 dbSNP
rs953379919 1437 dbSNP
rs984676885 1443 dbSNP
rs909996855 1448 dbSNP
rs183498027 1450 dbSNP
rs1490395875 1451 dbSNP
rs1045111964 1460 dbSNP
rs375266627 1467 dbSNP
rs927911672 1474 dbSNP
rs939259613 1475 dbSNP
rs1052325211 1479 dbSNP
rs1229458144 1484 dbSNP
rs4645974 1486 dbSNP
rs981019285 1493 dbSNP
rs926970808 1498 dbSNP
rs1413833784 1508 dbSNP
rs1398799140 1513 dbSNP
rs1158284340 1514 dbSNP
rs1010765105 1519 dbSNP
rs1423170080 1520 dbSNP
rs1448821393 1520 dbSNP
rs936984498 1523 dbSNP
rs1390434454 1524 dbSNP
rs1314776240 1526 dbSNP
rs565975495 1531 dbSNP
rs1476638471 1535 dbSNP
rs768048008 1541 dbSNP
rs1192381206 1548 dbSNP
rs1480475870 1555 dbSNP
rs895605998 1556 dbSNP
rs1196809999 1557 dbSNP
rs940402694 1560 dbSNP
rs1273394514 1564 dbSNP
rs1353674635 1569 dbSNP
rs1337302482 1573 dbSNP
rs1257331219 1588 dbSNP
rs570631438 1590 dbSNP
rs370450661 1602 dbSNP
rs1289234004 1614 dbSNP
rs1043940792 1616 dbSNP
rs1346192556 1624 dbSNP
rs370934681 1626 dbSNP
rs1403280540 1635 dbSNP
rs374076133 1638 dbSNP
rs1007679957 1639 dbSNP
rs1411991446 1642 dbSNP
rs1395054662 1643 dbSNP
rs898968610 1645 dbSNP
rs994773032 1653 dbSNP
rs1050320374 1656 dbSNP
rs1196878432 1657 dbSNP
rs1313345023 1659 dbSNP
rs4645975 1668 dbSNP
rs576210279 1678 dbSNP
rs1435856709 1682 dbSNP
rs965655026 1684 dbSNP
rs998410064 1688 dbSNP
rs1025875179 1696 dbSNP
rs1485068519 1703 dbSNP
rs775454005 1707 dbSNP
rs1182440846 1708 dbSNP
rs956812868 1712 dbSNP
rs1468381800 1720 dbSNP
rs1324394335 1722 dbSNP
rs1265014829 1726 dbSNP
rs1176456458 1741 dbSNP
rs951619162 1749 dbSNP
rs1425637769 1753 dbSNP
rs1344654504 1757 dbSNP
rs1009595034 1764 dbSNP
rs4645976 1765 dbSNP
rs1416062962 1770 dbSNP
rs1375124491 1771 dbSNP
rs1171686446 1786 dbSNP
rs746955010 1796 dbSNP
rs1022433552 1801 dbSNP
rs188398428 1802 dbSNP
rs1407659732 1805 dbSNP
rs910038577 1814 dbSNP
rs1173555274 1817 dbSNP
rs1413392428 1819 dbSNP
rs1408344995 1822 dbSNP
rs1373648518 1836 dbSNP
rs1159906509 1840 dbSNP
rs1468453235 1846 dbSNP
rs1379401057 1848 dbSNP
rs1184165028 1851 dbSNP
rs1434245624 1858 dbSNP
rs968164535 1862 dbSNP
rs1208191763 1868 dbSNP
rs981434654 1869 dbSNP
rs193204061 1872 dbSNP
rs981232062 1875 dbSNP
rs1225637793 1877 dbSNP
rs927966274 1880 dbSNP
rs62515808 1884 dbSNP
rs756756340 1889 dbSNP
rs1247360445 1893 dbSNP
rs77023277 1896 dbSNP
rs1368758532 1897 dbSNP
rs565952481 1898 dbSNP
rs1043567498 1899 dbSNP
rs888911114 1906 dbSNP
rs1007321773 1907 dbSNP
rs920426524 1914 dbSNP
rs1398551203 1916 dbSNP
rs1040076536 1921 dbSNP
rs901581696 1929 dbSNP
rs930426921 1935 dbSNP
rs539515638 1936 dbSNP
rs993152114 1939 dbSNP
rs557853775 1945 dbSNP
rs1472524506 1953 dbSNP
rs1242737990 1958 dbSNP
rs1218223151 1960 dbSNP
rs1487396802 1963 dbSNP
rs1285560206 1968 dbSNP
rs1274654133 1974 dbSNP
rs764801483 1979 dbSNP
rs1361995158 1984 dbSNP
rs889080895 1989 dbSNP
rs1203420196 1994 dbSNP
Experimental Support 1 for Non-Functional miRNA-Target Interaction
miRNA:Target xx
Validation Method
Conditions Hep G2
Disease MIMAT0000082
Location of target site 3'UTR
Tools used in this research miRanda , PicTar , TargetScan
Original Description (Extracted from the article) ... "MYC Is Not a Target of miR-26a.//Because these mice were constructed with a human MYC transgene that includes its 3'UTR (Felsher and Bishop ...

- Kota J; Chivukula RR; O'Donnell KA; Wentzel et al., 2009, Cell.

Article - Kota J; Chivukula RR; O'Donnell KA; Wentzel et al.
- Cell, 2009
Therapeutic strategies based on modulation of microRNA (miRNA) activity hold great promise due to the ability of these small RNAs to potently influence cellular behavior. In this study, we investigated the efficacy of a miRNA replacement therapy for liver cancer. We demonstrate that hepatocellular carcinoma (HCC) cells exhibit reduced expression of miR-26a, a miRNA that is normally expressed at high levels in diverse tissues. Expression of this miRNA in liver cancer cells in vitro induces cell-cycle arrest associated with direct targeting of cyclins D2 and E2. Systemic administration of this miRNA in a mouse model of HCC using adeno-associated virus (AAV) results in inhibition of cancer cell proliferation, induction of tumor-specific apoptosis, and dramatic protection from disease progression without toxicity. These findings suggest that delivery of miRNAs that are highly expressed and therefore tolerated in normal tissues but lost in disease cells may provide a general strategy for miRNA replacement therapies.
LinkOut: [PMID: 19524505]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Article - Lu J; He ML; Wang L; Chen Y; Liu X; Dong Q; et al.
- Cancer research, 2011
Several microRNAs (miRNA) have been implicated in nasopharyngeal carcinoma (NPC), a highly invasive and metastatic cancer that is widely prevalent in southern China. In this study, we report that microRNA miR-26a is commonly downregulated in NPC specimens and NPC cell lines with important functional consequences. Ectopic expression of miR-26a dramatically suppressed cell proliferation and colony formation by inducing G(1)-phase cell-cycle arrest. We found that miR-26a strongly reduced the expression of EZH2 oncogene in NPC cells. Similar to the restoring miR-26 expression, EZH2 downregulation inhibited cell growth and cell-cycle progression, whereas EZH2 overexpression rescued the suppressive effect of miR-26a. Mechanistic investigations revealed that miR-26a suppressed the expression of c-myc, the cyclin D3 and E2, and the cyclin-dependent kinase CDK4 and CDK6 while enhancing the expression of CDK inhibitors p14(ARF) and p21(CIP1) in an EZH2-dependent manner. Interestingly, cyclin D2 was regulated by miR-26a but not by EZH2, revealing cyclin D2 as another direct yet mechanistically distinct target of miR-26a. In clinical specimens, EZH2 was widely overexpressed and its mRNA levels were inversely correlated with miR-26a expression. Taken together, our results indicate that miR-26a functions as a growth-suppressive miRNA in NPC, and that its suppressive effects are mediated chiefly by repressing EZH2 expression.
LinkOut: [PMID: 21199804]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE19536 Breast cancer -0.295 1.4e-3 -0.283 2.2e-3 100 Click to see details
GSE19783 ER- ER- breast cancer -0.3 3.6e-3 -0.283 5.7e-3 79 Click to see details
GSE32688 Pancreatic cancer -0.457 4.3e-3 -0.273 6.5e-2 32 Click to see details
GSE17498 Multiple myeloma -0.41 4.3e-3 -0.399 5.4e-3 40 Click to see details
GSE21032 Prostate cancer -0.236 1.6e-2 -0.223 2.1e-2 83 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.434 2.8e-2 -0.653 9.0e-4 20 Click to see details
GSE19350 CNS germ cell tumors 0.513 4.4e-2 0.580 2.4e-2 12 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.331 5.3e-2 0.489 6.6e-3 25 Click to see details
GSE28544 Breast cancer 0.274 9.8e-2 0.533 3.7e-3 24 Click to see details
GSE17306 Multiple myeloma -0.184 1.0e-1 -0.174 1.2e-1 49 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.395 1.5e-1 0.650 2.9e-2 9 Click to see details
GSE14794 Lymphoblastoid cells -0.094 1.9e-1 -0.131 1.1e-1 90 Click to see details
GSE28260 Renal cortex and medulla 0.182 2.8e-1 0.121 3.5e-1 13 Click to see details
GSE26953 Aortic valvular endothelial cells 0.118 2.9e-1 0.073 3.7e-1 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.11 3.1e-1 -0.227 1.5e-1 23 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.1 3.2e-1 0.105 3.1e-1 25 Click to see details
GSE21849 B cell lymphoma 0.089 3.2e-1 0.194 1.6e-1 29 Click to see details
GSE19783 ER+ ER+ breast cancer -0.069 3.9e-1 -0.174 2.3e-1 20 Click to see details
GSE38226 Liver fibrosis 0.056 4.0e-1 0.101 3.3e-1 21 Click to see details
GSE27834 Pluripotent stem cells 0.033 4.5e-1 0.032 4.5e-1 16 Click to see details
GSE21687 Ependynoma primary tumors -0.008 4.7e-1 -0.032 4.0e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BLCA 0.597 0 0.534 0.01 18 Click to see details
ESCA -0.667 0.01 -0.791 0 11 Click to see details
BRCA 0.218 0.02 0.253 0.01 84 Click to see details
PCPG 0.99 0.05 0.500 0.33 3 Click to see details
LIHC 0.229 0.06 0.189 0.1 49 Click to see details
STAD -0.283 0.06 -0.442 0.01 32 Click to see details
UCEC 0.248 0.15 0.119 0.31 19 Click to see details
COAD -0.334 0.21 -0.190 0.33 8 Click to see details
LUSC -0.116 0.24 -0.196 0.12 38 Click to see details
PAAD 0.487 0.26 0.000 0.5 4 Click to see details
KICH 0.125 0.28 0.103 0.31 25 Click to see details
KIRC 0.067 0.29 -0.058 0.32 68 Click to see details
HNSC -0.075 0.32 -0.056 0.36 42 Click to see details
LUAD 0.138 0.33 0.182 0.29 12 Click to see details
KIRP 0.06 0.37 0.096 0.3 32 Click to see details
CHOL 0.122 0.38 0.000 0.5 9 Click to see details
THCA -0.039 0.38 -0.057 0.33 59 Click to see details
CESC 0.343 0.39 0.500 0.33 3 Click to see details
PRAD -0.039 0.39 0.014 0.46 50 Click to see details
PRAD -0.039 0.39 0.014 0.46 50 Click to see details
PRAD -0.039 0.39 0.014 0.46 50 Click to see details
449 hsa-miR-26a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000109 HMGA2 high mobility group AT-hook 2 4 5
MIRT000110 HMGA1 high mobility group AT-hook 1 3 5
MIRT000111 CCNE2 cyclin E2 4 2
MIRT000112 CCND2 cyclin D2 5 10
MIRT001021 CDK8 cyclin dependent kinase 8 2 2
MIRT001022 CDC6 cell division cycle 6 3 3
MIRT001039 LIF LIF, interleukin 6 family cytokine 1 2
MIRT001095 PTEN phosphatase and tensin homolog 4 7
MIRT001771 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 5 11
MIRT001772 PLAG1 PLAG1 zinc finger 3 2
MIRT002315 SERBP1 SERPINE1 mRNA binding protein 1 3 3
MIRT002340 SMAD1 SMAD family member 1 4 6
MIRT003212 MAP3K2 mitogen-activated protein kinase kinase kinase 2 3 2
MIRT003213 RB1 RB transcriptional corepressor 1 5 2
MIRT003803 SMAD4 SMAD family member 4 3 3
MIRT003968 MYC MYC proto-oncogene, bHLH transcription factor 2 2
MIRT004338 CTGF connective tissue growth factor 2 2
MIRT004339 STRADB STE20-related kinase adaptor beta 4 4
MIRT004615 IFNB1 interferon beta 1 3 2
MIRT004676 GSK3B glycogen synthase kinase 3 beta 7 10
MIRT005587 CPEB2 cytoplasmic polyadenylation element binding protein 2 3 2
MIRT005588 CPEB3 cytoplasmic polyadenylation element binding protein 3 4 2
MIRT005589 CPEB4 cytoplasmic polyadenylation element binding protein 4 3 2
MIRT005751 GDAP1 ganglioside induced differentiation associated protein 1 3 1
MIRT005920 MTDH metadherin 5 4
MIRT006306 CDK6 cyclin dependent kinase 6 2 1
MIRT006309 CCNE1 cyclin E1 3 2
MIRT006389 ESR1 estrogen receptor 1 1 1
MIRT006711 ABCA1 ATP binding cassette subfamily A member 1 2 1
MIRT006712 ARL4C ADP ribosylation factor like GTPase 4C 2 1
MIRT007177 E2F7 E2F transcription factor 7 2 7
MIRT007347 NOS2 nitric oxide synthase 2 3 2
MIRT007374 IL6 interleukin 6 2 1
MIRT030358 TGFBR2 transforming growth factor beta receptor 2 3 1
MIRT050053 HIST1H4E histone cluster 1 H4 family member e 1 1
MIRT050054 ZNF814 zinc finger protein 814 1 1
MIRT050055 ZNF233 zinc finger protein 233 1 1
MIRT050056 ABCB7 ATP binding cassette subfamily B member 7 1 1
MIRT050057 SCRN1 secernin 1 1 1
MIRT050058 NABP1 nucleic acid binding protein 1 2 8
MIRT050059 FAM20B FAM20B, glycosaminoglycan xylosylkinase 1 1
MIRT050060 ARCN1 archain 1 1 1
MIRT050061 ANO3 anoctamin 3 1 1
MIRT050062 TFAM transcription factor A, mitochondrial 1 1
MIRT050063 FER FER tyrosine kinase 1 1
MIRT050064 HIAT1 major facilitator superfamily domain containing 14A 1 1
MIRT050065 PPP1CC protein phosphatase 1 catalytic subunit gamma 1 1
MIRT050066 SLC35B4 solute carrier family 35 member B4 1 1
MIRT050067 RASA1 RAS p21 protein activator 1 1 1
MIRT050068 COX1 cytochrome c oxidase subunit I 1 1
MIRT050069 MSL3 MSL complex subunit 3 1 1
MIRT050070 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 1 1
MIRT050071 GIT2 GIT ArfGAP 2 1 1
MIRT050072 DNMT1 DNA methyltransferase 1 1 1
MIRT050073 MFHAS1 malignant fibrous histiocytoma amplified sequence 1 1 1
MIRT050074 UBA2 ubiquitin like modifier activating enzyme 2 1 1
MIRT050075 DCAF7 DDB1 and CUL4 associated factor 7 1 1
MIRT050076 MTRF1 mitochondrial translation release factor 1 1 1
MIRT050077 WBSCR16 RCC1 like 1 1
MIRT050078 NUAK1 NUAK family kinase 1 1 1
MIRT050079 TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 1 1
MIRT050080 PNMA2 paraneoplastic Ma antigen 2 1 1
MIRT050081 ACTL8 actin like 8 1 1
MIRT050082 HSPA8 heat shock protein family A (Hsp70) member 8 1 1
MIRT050083 DHX15 DEAH-box helicase 15 1 1
MIRT050084 TCP1 t-complex 1 1 1
MIRT050085 SLC25A5 solute carrier family 25 member 5 1 1
MIRT050086 LSM14A LSM14A, mRNA processing body assembly factor 1 1
MIRT050087 CAMKV CaM kinase like vesicle associated 1 1
MIRT050088 ALG10B ALG10B, alpha-1,2-glucosyltransferase 1 1
MIRT050089 TYW1 tRNA-yW synthesizing protein 1 homolog 1 1
MIRT050090 RPL13A ribosomal protein L13a 1 1
MIRT050091 AGO1 argonaute 1, RISC catalytic component 1 1
MIRT050092 TXLNG taxilin gamma 1 1
MIRT050093 RAB18 RAB18, member RAS oncogene family 1 1
MIRT050094 RPS27A ribosomal protein S27a 1 1
MIRT050095 RPS26 ribosomal protein S26 1 1
MIRT050096 PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing 1 1
MIRT050097 TP53INP1 tumor protein p53 inducible nuclear protein 1 1 1
MIRT050098 ZNF703 zinc finger protein 703 1 1
MIRT050099 MTRF1L mitochondrial translational release factor 1 like 1 1
MIRT050100 ZNF506 zinc finger protein 506 1 1
MIRT050101 KCTD5 potassium channel tetramerization domain containing 5 1 1
MIRT050102 CTC1 CST telomere replication complex component 1 1 1
MIRT050103 TKT transketolase 1 1
MIRT050104 LYST lysosomal trafficking regulator 1 1
MIRT050105 FAM134A reticulophagy regulator family member 2 1 1
MIRT050106 NKX2-5 NK2 homeobox 5 1 1
MIRT050107 AURKAIP1 aurora kinase A interacting protein 1 1 1
MIRT050108 ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 1 1
MIRT050109 COASY Coenzyme A synthase 1 1
MIRT050110 CTR9 CTR9 homolog, Paf1/RNA polymerase II complex component 1 1
MIRT050111 COX3 cytochrome c oxidase III 1 1
MIRT050112 ELOVL6 ELOVL fatty acid elongase 6 1 1
MIRT050113 PIGT phosphatidylinositol glycan anchor biosynthesis class T 1 1
MIRT050114 TMCC3 transmembrane and coiled-coil domain family 3 1 1
MIRT050115 ARHGEF1 Rho guanine nucleotide exchange factor 1 1 1
MIRT050116 SHC2 SHC adaptor protein 2 1 1
MIRT050117 PSMA3 proteasome subunit alpha 3 1 1
MIRT050118 PTTG1 pituitary tumor-transforming 1 1 1
MIRT050119 RPS24 ribosomal protein S24 1 1
MIRT050120 SPTBN1 spectrin beta, non-erythrocytic 1 1 1
MIRT050121 UBTF upstream binding transcription factor, RNA polymerase I 1 1
MIRT050122 BTBD3 BTB domain containing 3 1 1
MIRT050123 AHR aryl hydrocarbon receptor 1 1
MIRT050124 EEF1B2 eukaryotic translation elongation factor 1 beta 2 1 1
MIRT050125 MRPL51 mitochondrial ribosomal protein L51 1 1
MIRT050126 SETD2 SET domain containing 2 1 1
MIRT050127 LRP6 LDL receptor related protein 6 1 1
MIRT050128 RHOBTB1 Rho related BTB domain containing 1 1 1
MIRT050129 HIST1H4J histone cluster 1 H4 family member j 1 1
MIRT050130 MYO10 myosin X 1 1
MIRT050131 ATP7B ATPase copper transporting beta 1 1
MIRT050132 CSRP2BP lysine acetyltransferase 14 1 1
MIRT050133 RBM39 RNA binding motif protein 39 1 1
MIRT050134 C14orf37 chromosome 14 open reading frame 37 2 3
MIRT050135 SFMBT1 Scm like with four mbt domains 1 1 1
MIRT050136 KIAA1704 GPALPP motifs containing 1 1 1
MIRT050137 ABCB9 ATP binding cassette subfamily B member 9 1 1
MIRT050138 ADM adrenomedullin 2 11
MIRT050139 USP7 ubiquitin specific peptidase 7 1 1
MIRT050140 TTN titin 1 1
MIRT050141 HNRNPU heterogeneous nuclear ribonucleoprotein U 1 1
MIRT050142 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 1 1
MIRT050143 CEPT1 choline/ethanolamine phosphotransferase 1 1 1
MIRT050144 HOXC8 homeobox C8 1 1
MIRT050145 CTBP1 C-terminal binding protein 1 1 1
MIRT050146 SET SET nuclear proto-oncogene 1 1
MIRT050147 MCM3AP minichromosome maintenance complex component 3 associated protein 1 1
MIRT050148 TPGS2 tubulin polyglutamylase complex subunit 2 1 1
MIRT050149 CA2 carbonic anhydrase 2 1 1
MIRT050150 PCYT1A phosphate cytidylyltransferase 1, choline, alpha 1 1
MIRT050151 ACTN4 actinin alpha 4 1 1
MIRT050152 EPG5 ectopic P-granules autophagy protein 5 homolog 1 1
MIRT050153 OLA1 Obg like ATPase 1 1 1
MIRT050154 RRM2 ribonucleotide reductase regulatory subunit M2 1 1
MIRT050155 BBX BBX, HMG-box containing 1 1
MIRT050156 NUP205 nucleoporin 205 1 1
MIRT050157 C6orf47 chromosome 6 open reading frame 47 1 1
MIRT050158 CFLAR CASP8 and FADD like apoptosis regulator 1 1
MIRT050159 SEC31A SEC31 homolog A, COPII coat complex component 1 1
MIRT050160 GLG1 golgi glycoprotein 1 1 1
MIRT050161 TBC1D16 TBC1 domain family member 16 1 1
MIRT050162 BTBD9 BTB domain containing 9 1 1
MIRT050163 RND2 Rho family GTPase 2 1 1
MIRT050164 TUBG1 tubulin gamma 1 1 1
MIRT050165 AHRR aryl-hydrocarbon receptor repressor 1 1
MIRT050166 CNTD2 cyclin N-terminal domain containing 2 1 1
MIRT050167 UBE2A ubiquitin conjugating enzyme E2 A 1 1
MIRT050168 CCDC43 coiled-coil domain containing 43 1 1
MIRT050169 MSH6 mutS homolog 6 1 1
MIRT050170 HIST4H4 histone cluster 4 H4 1 1
MIRT050171 C17orf51 chromosome 17 open reading frame 51 1 1
MIRT050172 SLC25A30 solute carrier family 25 member 30 1 1
MIRT050173 USB1 U6 snRNA biogenesis phosphodiesterase 1 1 1
MIRT050174 MYH10 myosin heavy chain 10 1 1
MIRT050175 LINS lines homolog 1 1 1
MIRT050176 UBR4 ubiquitin protein ligase E3 component n-recognin 4 1 2
MIRT050177 ZNF207 zinc finger protein 207 1 1
MIRT050178 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 1 1
MIRT050179 TXNL1 thioredoxin like 1 1 1
MIRT050180 FOXO3 forkhead box O3 1 1
MIRT050181 COPB1 coatomer protein complex subunit beta 1 1 1
MIRT050182 FASN fatty acid synthase 1 1
MIRT050183 SARS seryl-tRNA synthetase 1 1
MIRT050184 DDB1 damage specific DNA binding protein 1 1 1
MIRT050185 PPIA peptidylprolyl isomerase A 1 1
MIRT050186 SLC35A4 solute carrier family 35 member A4 1 1
MIRT050187 TXNDC11 thioredoxin domain containing 11 1 1
MIRT050188 HIST2H2AA3 histone cluster 2 H2A family member a3 1 1
MIRT050189 TRAP1 TNF receptor associated protein 1 1 1
MIRT050190 SDCBP syndecan binding protein 1 1
MIRT050191 ASCC2 activating signal cointegrator 1 complex subunit 2 1 1
MIRT050192 KDM5C lysine demethylase 5C 1 1
MIRT050193 DST dystonin 1 1
MIRT050194 CLIC4 chloride intracellular channel 4 1 1
MIRT050195 WWP2 WW domain containing E3 ubiquitin protein ligase 2 1 1
MIRT050196 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 1 1
MIRT050197 RPL13 ribosomal protein L13 1 1
MIRT050198 CNBP CCHC-type zinc finger nucleic acid binding protein 1 1
MIRT052649 MCL1 MCL1, BCL2 family apoptosis regulator 1 1
MIRT052903 CHD1 chromodomain helicase DNA binding protein 1 2 1
MIRT053077 CKS2 CDC28 protein kinase regulatory subunit 2 4 3
MIRT053097 PRKCD protein kinase C delta 4 2
MIRT053251 BAG4 BCL2 associated athanogene 4 2 1
MIRT053574 FGF9 fibroblast growth factor 9 3 1
MIRT054062 ACVR1 activin A receptor type 1 2 1
MIRT054415 AMACR alpha-methylacyl-CoA racemase 3 1
MIRT054432 ATM ATM serine/threonine kinase 3 1
MIRT054484 RCBTB1 RCC1 and BTB domain containing protein 1 3 1
MIRT054645 HGF hepatocyte growth factor 3 1
MIRT054676 LIN28B lin-28 homolog B 3 1
MIRT054677 ZCCHC11 zinc finger CCHC-type containing 11 3 1
MIRT060004 VANGL2 VANGL planar cell polarity protein 2 2 4
MIRT062177 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT064905 ZBTB18 zinc finger and BTB domain containing 18 2 6
MIRT066809 ZDHHC18 zinc finger DHHC-type containing 18 2 3
MIRT067540 METAP2 methionyl aminopeptidase 2 1 1
MIRT072092 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 5
MIRT072125 RTF1 RTF1 homolog, Paf1/RNA polymerase II complex component 1 1
MIRT073375 ABHD2 abhydrolase domain containing 2 1 1
MIRT075111 C16ORF70 chromosome 16 open reading frame 70 2 5
MIRT080605 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 8
MIRT085205 SLC5A3 solute carrier family 5 member 3 2 2
MIRT086007 UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2 2
MIRT087899 TNRC6B trinucleotide repeat containing 6B 2 5
MIRT089450 TET3 tet methylcytosine dioxygenase 3 2 3
MIRT089599 MAT2A methionine adenosyltransferase 2A 2 11
MIRT090517 SLC25A36 solute carrier family 25 member 36 2 2
MIRT097631 POLR3G RNA polymerase III subunit G 1 1
MIRT118410 DNMT3B DNA methyltransferase 3 beta 4 1
MIRT122040 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 1 1
MIRT133477 EP400 E1A binding protein p400 1 1
MIRT134087 KLHL42 kelch like family member 42 1 1
MIRT136529 KPNA6 karyopherin subunit alpha 6 1 1
MIRT137414 RLF rearranged L-myc fusion 1 1
MIRT137577 RCOR1 REST corepressor 1 1 1
MIRT137722 EIF5 eukaryotic translation initiation factor 5 1 1
MIRT147274 KPNA2 karyopherin subunit alpha 2 2 10
MIRT151691 CHAF1A chromatin assembly factor 1 subunit A 1 1
MIRT156734 FAM126B family with sequence similarity 126 member B 2 2
MIRT159273 RASGRP3 RAS guanyl releasing protein 3 1 1
MIRT166022 SFXN1 sideroflexin 1 1 1
MIRT166592 ZSWIM6 zinc finger SWIM-type containing 6 1 1
MIRT168865 PIM1 Pim-1 proto-oncogene, serine/threonine kinase 1 1
MIRT168937 IRF4 interferon regulatory factor 4 1 1
MIRT169515 TTK TTK protein kinase 1 1
MIRT169560 PNRC1 proline rich nuclear receptor coactivator 1 1 1
MIRT170138 KLHDC10 kelch domain containing 10 1 1
MIRT175075 DCAF10 DDB1 and CUL4 associated factor 10 1 1
MIRT183141 WEE1 WEE1 G2 checkpoint kinase 2 1
MIRT187790 ANKRD52 ankyrin repeat domain 52 1 1
MIRT191753 ZNF410 zinc finger protein 410 2 2
MIRT193070 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT193726 USP3 ubiquitin specific peptidase 3 1 1
MIRT203408 DYRK1A dual specificity tyrosine phosphorylation regulated kinase 1A 1 1
MIRT206543 RHOQ ras homolog family member Q 2 2
MIRT210981 TET2 tet methylcytosine dioxygenase 2 1 1
MIRT213685 PTPN13 protein tyrosine phosphatase, non-receptor type 13 3 1
MIRT215349 CREBRF CREB3 regulatory factor 2 2
MIRT227685 TBC1D13 TBC1 domain family member 13 2 2
MIRT243962 MAP1B microtubule associated protein 1B 2 2
MIRT250410 TNRC6A trinucleotide repeat containing 6A 2 7
MIRT262152 OTUD1 OTU deubiquitinase 1 1 1
MIRT277212 AKIRIN1 akirin 1 2 2
MIRT286389 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 3
MIRT308147 PDE12 phosphodiesterase 12 2 2
MIRT319694 UBN2 ubinuclein 2 2 3
MIRT327077 KLHL15 kelch like family member 15 2 10
MIRT346489 SSX2IP SSX family member 2 interacting protein 1 1
MIRT438130 ADAM17 ADAM metallopeptidase domain 17 6 3
MIRT438159 PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha 1 1
MIRT438209 CHEK1 checkpoint kinase 1 2 1
MIRT438638 TDG thymine DNA glycosylase 1 1
MIRT438656 PHB prohibitin 3 1
MIRT444707 ZNF772 zinc finger protein 772 2 2
MIRT448615 OTUD4 OTU deubiquitinase 4 2 2
MIRT451358 UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI 2 2
MIRT457292 ZBTB45 zinc finger and BTB domain containing 45 2 2
MIRT458763 CES2 carboxylesterase 2 2 2
MIRT458855 CD55 CD55 molecule (Cromer blood group) 2 2
MIRT460261 SLC26A2 solute carrier family 26 member 2 2 2
MIRT461702 ZNF426 zinc finger protein 426 2 2
MIRT465730 TMTC3 transmembrane and tetratricopeptide repeat containing 3 2 2
MIRT466688 TAF13 TATA-box binding protein associated factor 13 2 4
MIRT468541 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT468809 SACS sacsin molecular chaperone 2 11
MIRT470198 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT476009 GTF2A1 general transcription factor IIA subunit 1 2 8
MIRT477228 ETF1 eukaryotic translation termination factor 1 2 4
MIRT477752 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT478346 DDIT4 DNA damage inducible transcript 4 2 2
MIRT478525 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT480793 BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 2 6
MIRT482242 AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 2 2
MIRT486465 MDM2 MDM2 proto-oncogene 2 10
MIRT487561 LOXL2 lysyl oxidase like 2 2 2
MIRT498663 ZNF664 zinc finger protein 664 2 8
MIRT499509 RNF6 ring finger protein 6 2 6
MIRT502456 FRAT2 FRAT2, WNT signaling pathway regulator 2 6
MIRT502713 CREBZF CREB/ATF bZIP transcription factor 2 6
MIRT502853 CHEK2 checkpoint kinase 2 2 6
MIRT507558 DEPDC1 DEP domain containing 1 2 6
MIRT524742 BRCA1 BRCA1, DNA repair associated 2 2
MIRT527178 LRRTM4 leucine rich repeat transmembrane neuronal 4 2 2
MIRT527909 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT532895 ZNF451 zinc finger protein 451 2 2
MIRT533588 TOB1 transducer of ERBB2, 1 2 7
MIRT534368 SETD8 lysine methyltransferase 5A 2 4
MIRT535060 PPP2R5D protein phosphatase 2 regulatory subunit B'delta 2 4
MIRT536204 MAD2L1 mitotic arrest deficient 2 like 1 2 2
MIRT537233 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2 2
MIRT539774 KIAA0408 KIAA0408 2 6
MIRT540867 ZBTB24 zinc finger and BTB domain containing 24 2 2
MIRT541042 SOGA3 SOGA family member 3 2 6
MIRT541350 DDX3X DEAD-box helicase 3, X-linked 2 2
MIRT544949 TUB tubby bipartite transcription factor 2 4
MIRT545809 ZNF608 zinc finger protein 608 2 2
MIRT547008 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 2
MIRT551188 EPB41L3 erythrocyte membrane protein band 4.1 like 3 2 2
MIRT551973 TMEM19 transmembrane protein 19 2 2
MIRT552044 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT553325 TSC22D2 TSC22 domain family member 2 2 2
MIRT554367 SFPQ splicing factor proline and glutamine rich 2 2
MIRT555741 PDCD10 programmed cell death 10 2 2
MIRT556346 MAN2A1 mannosidase alpha class 2A member 1 2 3
MIRT560389 TMEM254 transmembrane protein 254 2 2
MIRT560465 SMIM9 small integral membrane protein 9 2 2
MIRT561122 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT562626 ARNTL2 aryl hydrocarbon receptor nuclear translocator like 2 2 2
MIRT564084 NSA2 NSA2, ribosome biogenesis homolog 2 2
MIRT564207 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT565191 TSHZ1 teashirt zinc finger homeobox 1 2 2
MIRT567887 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT568259 BMP2K BMP2 inducible kinase 2 2
MIRT568505 ARF1 ADP ribosylation factor 1 2 2
MIRT572178 CDV3 CDV3 homolog 2 2
MIRT574711 HAUS8 HAUS augmin like complex subunit 8 2 3
MIRT610597 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 2
MIRT614445 WDR92 WD repeat domain 92 2 2
MIRT615442 FAXC failed axon connections homolog 2 2
MIRT618503 HSPD1 heat shock protein family D (Hsp60) member 1 2 2
MIRT618903 CDK9 cyclin dependent kinase 9 2 2
MIRT620083 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT620286 GLTP glycolipid transfer protein 2 2
MIRT622464 RNF11 ring finger protein 11 2 2
MIRT624644 ASXL3 additional sex combs like 3, transcriptional regulator 2 2
MIRT624697 AQR aquarius intron-binding spliceosomal factor 2 2
MIRT625256 ZNF566 zinc finger protein 566 2 2
MIRT628258 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT628872 FAM177A1 family with sequence similarity 177 member A1 2 2
MIRT630720 FPR1 formyl peptide receptor 1 2 2
MIRT631887 SLFN13 schlafen family member 13 2 2
MIRT637716 MYOZ3 myozenin 3 2 2
MIRT639892 SSR3 signal sequence receptor subunit 3 2 2
MIRT642506 ORC6 origin recognition complex subunit 6 2 2
MIRT644723 SEPT14 septin 14 2 2
MIRT645341 AGTPBP1 ATP/GTP binding protein 1 2 2
MIRT648886 TUBGCP5 tubulin gamma complex associated protein 5 2 2
MIRT653565 SLC35B3 solute carrier family 35 member B3 2 2
MIRT656095 MTA3 metastasis associated 1 family member 3 2 2
MIRT660204 BMPR1A bone morphogenetic protein receptor type 1A 2 2
MIRT660753 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT661379 RHCG Rh family C glycoprotein 2 2
MIRT662310 ADM2 adrenomedullin 2 2 2
MIRT662628 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT663688 ZNF347 zinc finger protein 347 2 2
MIRT665109 FKTN fukutin 2 2
MIRT665262 ZKSCAN1 zinc finger with KRAB and SCAN domains 1 2 2
MIRT666273 SLC31A1 solute carrier family 31 member 1 2 2
MIRT666646 RBM48 RNA binding motif protein 48 2 2
MIRT667511 LUC7L2 LUC7 like 2, pre-mRNA splicing factor 2 2
MIRT669228 C7orf55-LUC7L2 C7orf55-LUC7L2 readthrough 2 2
MIRT669271 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT671783 RGS17 regulator of G protein signaling 17 2 2
MIRT672379 RPL37 ribosomal protein L37 2 2
MIRT673464 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT673600 HPSE heparanase 2 4
MIRT676269 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT676514 RNF216 ring finger protein 216 2 2
MIRT676653 LRRC27 leucine rich repeat containing 27 2 2
MIRT677335 PHAX phosphorylated adaptor for RNA export 2 2
MIRT677523 OCIAD2 OCIA domain containing 2 2 2
MIRT677548 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT677724 SSR1 signal sequence receptor subunit 1 2 2
MIRT677800 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT677885 DCP1A decapping mRNA 1A 2 2
MIRT678104 MICA MHC class I polypeptide-related sequence A 2 2
MIRT678431 PDE4C phosphodiesterase 4C 2 2
MIRT678488 ARHGEF39 Rho guanine nucleotide exchange factor 39 2 2
MIRT678898 TTLL12 tubulin tyrosine ligase like 12 2 2
MIRT679296 SSBP2 single stranded DNA binding protein 2 2 2
MIRT679572 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT680003 ZNF860 zinc finger protein 860 2 2
MIRT694963 PLAC8 placenta specific 8 2 2
MIRT697861 UBE2H ubiquitin conjugating enzyme E2 H 2 2
MIRT698310 TMEM2 transmembrane protein 2 2 2
MIRT701712 MTMR12 myotubularin related protein 12 2 2
MIRT705964 ACBD5 acyl-CoA binding domain containing 5 2 2
MIRT714342 DIP2A disco interacting protein 2 homolog A 2 2
MIRT715309 POLR2E RNA polymerase II subunit E 2 2
MIRT717477 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT719604 PRKX protein kinase, X-linked 2 2
MIRT724483 CSNK1A1 casein kinase 1 alpha 1 2 2
MIRT726021 ZNF680 zinc finger protein 680 1 1
MIRT726041 ZNF254 zinc finger protein 254 1 1
MIRT726096 WNT5A Wnt family member 5A 1 1
MIRT726288 TMEM30A transmembrane protein 30A 1 1
MIRT726312 TMCC1 transmembrane and coiled-coil domain family 1 1 1
MIRT726446 SSH2 slingshot protein phosphatase 2 1 1
MIRT726486 SMEK1 protein phosphatase 4 regulatory subunit 3A 1 1
MIRT726514 SLC7A1 solute carrier family 7 member 1 1 1
MIRT726535 SLC38A2 solute carrier family 38 member 2 1 1
MIRT726657 SASS6 SAS-6 centriolar assembly protein 1 1
MIRT726778 REEP4 receptor accessory protein 4 1 1
MIRT726937 PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 1 1
MIRT726989 PDE4B phosphodiesterase 4B 1 1
MIRT727060 NUDT19 nudix hydrolase 19 1 1
MIRT727062 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 1 1
MIRT727485 HSPA13 heat shock protein family A (Hsp70) member 13 1 1
MIRT727488 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 1 1
MIRT727508 HECTD3 HECT domain E3 ubiquitin protein ligase 3 1 1
MIRT727675 FBXO11 F-box protein 11 1 1
MIRT727780 ELAVL2 ELAV like RNA binding protein 2 1 1
MIRT727786 EIF4G2 eukaryotic translation initiation factor 4 gamma 2 1 1
MIRT727793 EHD1 EH domain containing 1 1 1
MIRT727863 DNMBP dynamin binding protein 1 1
MIRT727903 DCTN4 dynactin subunit 4 1 1
MIRT727941 CPSF2 cleavage and polyadenylation specific factor 2 1 1
MIRT727966 COX5A cytochrome c oxidase subunit 5A 1 1
MIRT728000 CHORDC1 cysteine and histidine rich domain containing 1 3 1
MIRT728203 BID BH3 interacting domain death agonist 1 1
MIRT728213 BCL7B BCL tumor suppressor 7B 1 1
MIRT728306 ARPP19 cAMP regulated phosphoprotein 19 1 1
MIRT728331 AP1S3 adaptor related protein complex 1 sigma 3 subunit 1 1
MIRT728396 ACSL3 acyl-CoA synthetase long chain family member 3 1 1
MIRT731168 ITGA5 integrin subunit alpha 5 2 1
MIRT731390 DUSP4 dual specificity phosphatase 4 3 1
MIRT732062 NRAS NRAS proto-oncogene, GTPase 3 1
MIRT732063 E2F2 E2F transcription factor 2 3 1
MIRT732182 PTGS2 prostaglandin-endoperoxide synthase 2 6 2
MIRT732280 JAG1 jagged 1 3 1
MIRT732490 NRP1 neuropilin 1 1 0
MIRT732621 MS multiple sclerosis 1 0
MIRT733344 CREB1 cAMP responsive element binding protein 1 4 0
MIRT733365 ADIPOQ adiponectin, C1Q and collagen domain containing 1 0
MIRT733699 NORAD non-coding RNA activated by DNA damage 2 0
MIRT733700 UBE3A ubiquitin protein ligase E3A 2 0
MIRT733702 CCND1 cyclin D1 2 0
MIRT733703 TGFBR1 transforming growth factor beta receptor 1 2 0
MIRT734551 SHC4 SHC adaptor protein 4 2 0
MIRT734552 PFDN4 prefoldin subunit 4 2 0
MIRT734721 CD38 CD38 molecule 3 0
MIRT736775 MAP2 microtubule associated protein 2 2 0
MIRT736838 USP35 ubiquitin specific peptidase 35 2 0
MIRT736852 EIF2A eukaryotic translation initiation factor 2A 2 0
MIRT737078 ULK1 unc-51 like autophagy activating kinase 1 3 0
MIRT737079 SNHG6 small nucleolar RNA host gene 6 3 0
MIRT737091 ULK2 unc-51 like autophagy activating kinase 2 3 0
MIRT737491 FLI1 Fli-1 proto-oncogene, ETS transcription factor 2 0
MIRT755414 NEK6 NIMA related kinase 6 3 1
MIRT755509 ICAM1 intercellular adhesion molecule 1 1 1
MIRT755687 RUNX2 runt related transcription factor 2 3 1
MIRT755688 SPP1 secreted phosphoprotein 1 3 1
MIRT755689 ALPL alkaline phosphatase, liver/bone/kidney 3 1
MIRT756239 NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding) 2 1
MIRT756240 FANCE Fanconi anemia complementation group E 3 1
MIRT756287 ZBTB7C zinc finger and BTB domain containing 7C 3 1
MIRT756352 PLCB1 phospholipase C beta 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-26a Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 down-regulated
miR-26a Curcumin NULL 969516 Microarray BxPC-3 human pancreatic carcinoma cell line 18347134 2008 down-regulated
miR-26a Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miR-26a Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-26a Morphine approved 5288826 Microarray human monocyte-derived macrophages (h-mdms) infection with HIV-1 20564181 2010 down-regulated
miR-26a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-26a Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
miR-26a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
miR-26a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
miR-26a Tamoxifen approved 2733526 Quantitative real-time PCR breast cancer 22094936 2012 up-regulated
miR-26a CDF(analogues of curcumin) NULL NULL Quantitative real-time PCR pancreatic cancer cells 22108826 2012 up-regulated
miR-26a Metformin approved 4091 Quantitative real-time PCR Pancreatic Neoplasms 22245693 2012 up-regulated
miR-26a Trastuzumab approved NULL Microarray HER2-positive breast cancer 22384020 2012 up-regulated
miR-26a Trastuzumab approved NULL Quantitative real-time PCR HER2-positive breast cancer 22384020 2012 up-regulated
miR-26a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-26a 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 down-regulated
miR-26a Sevoflurane approved 5206 Quantitative real-time PCR lung cell 23124245 2012 down-regulated
miR-26a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 up-regulated
miR-26a Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 up-regulated
miR-26a Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice liver 20145010 2010 up-regulated
miR-26a Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-26a Nicotine approved 89594 Microarray Rat adrenal pheochromocytoma PC12 cell 18845019 2009 up-regulated
miR-26a Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
miR-26a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-26a Marine fungal metabolite 1386A NULL NULL Microarray MCF-7 breast cancer cells. 22159329 2012 up-regulated
miR-26a Trastuzumab approved NULL Microarray BT474 cells 22384020 2012 up-regulated
miR-26a Trastuzumab approved NULL Microarray SKBR3 cells. 22384020 2012 up-regulated
miR-26a Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
miR-26a Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
miR-26a Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 down-regulated
miR-26a Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice liver 20145010 2010 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-26a-5p [(1R,2R,3E,7S,11E,13S,15S)-15-hydroxy-7-methyl-5-oxo-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-2-yl] (2R)-2-(dimethylamino)-3-methylbutanoate;hydrochloride 45028997 NSC745103 resistant
hsa-miR-26a-5p 1-[(E)-[phenyl(pyridin-2-yl)methylidene]amino]-3-(2-pyridin-2-ylethyl)thiourea 9571616 NSC689531 sensitive
hsa-miR-26a-5p 1-[phenyl(2-pyridinyl)methylene]-4-(2-methylphenyl)thiosemicarbazide 6148953 NSC668326 sensitive
hsa-miR-26a-5p 1-cyclohexyl-3-[(e)-[phenyl(2-pyridyl)methylene]amino]urea 6179448 NSC689539 sensitive
hsa-miR-26a-5p 2',6'-dibromospiro[7,8-dihydro-6h-pyrido[2,3-g]quinoline-9,4'-cyclohexa-2,5-diene]-1',5,10-trione 383051 NSC671095 resistant
hsa-miR-26a-5p 2-hydroxy-N-[(E)-1-[6-[(E)-N-[(2-hydroxybenzoyl)amino]-C-methylcarbonimidoyl]pyridin-2-yl]ethylideneamino]benzamide 5779747 NSC617573 sensitive
hsa-miR-26a-5p 2,7-dicyanoxanthone 363841 NSC629107 resistant
hsa-miR-26a-5p 3-[(Z)-[phenyl(pyridin-2-yl)methylidene]amino]-1,1-bis(pyridin-2-ylmethyl)thiourea 5466413 NSC689533 sensitive
hsa-miR-26a-5p 3-imino-n-(4-methylphenyl)-5-(methylthio)-1-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide 390314 NSC687606 resistant
hsa-miR-26a-5p 3,5,12,14-tetrabutyl-7,10-dithia-8,9-diselena-3,5,12,14-tetrazatricyclo[9.3.0.02,6]tetradeca-1(11),2(6)-diene-4,13-diselone 395765 NSC700584 sensitive
hsa-miR-26a-5p 4-amino-2-(4-chloroanilino)-5-(4-methylbenzoyl)-n-phenyl-1h-pyrrole-3-carbothioamide 5472799 NSC721554 resistant
hsa-miR-26a-5p 4-amino-8-chloro-2-(4-chlorophenyl)iminopyrimido[2,1-b][1,3]benzothiazole-3-carbonitrile 45029233 NSC745678 resistant
hsa-miR-26a-5p 5-chloro-N-[(E)-[phenyl(pyridin-2-yl)methylidene]amino]pyridin-2-amine 6519698 NSC693627 sensitive
hsa-miR-26a-5p 5-chloro-n-[(e)-1-pyridin-2-ylethylideneamino]-1,3-benzothiazol-2-amine 9572096 NSC703111 sensitive
hsa-miR-26a-5p 5-fluoro-n-[(e)-1-pyridin-2-ylethylideneamino]-1,3-benzothiazol-2-amine 9572046 NSC693634 sensitive
hsa-miR-26a-5p 5-nitro-n-[(e)-[phenyl(pyridin-2-yl)methylidene]amino]pyridin-2-amine 6519692 NSC693620 sensitive
hsa-miR-26a-5p 7-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3h-thieno[3,4-d]pyrimidine-4-thione 3005067 NSC670036 sensitive
hsa-miR-26a-5p 9-[(2e)-2-(4-chlorophenyl)-2-hydroxyiminoethoxy]chromeno[3,4-b]chromene-6,12-dione 9572588 NSC721045 resistant
hsa-miR-26a-5p 9-acridinamine, n-(4-ethoxyphenyl)-, monohydrochloride 2788193 NSC165714 resistant
hsa-miR-26a-5p Crambescidin 800 trihydrochloride 400719 NSC713155 resistant
hsa-miR-26a-5p Crotonosid 223996 NSC12161 sensitive
hsa-miR-26a-5p Cryptophycin b 5468424 NSC670038 resistant
hsa-miR-26a-5p Laurusin 135476719 NSC106486 sensitive
hsa-miR-26a-5p N'-(2-hydroxy-5-(hydroxy(oxido)amino)benzylidene)-1-piperidinecarbothiohydrazide 135484941 NSC689530 sensitive
hsa-miR-26a-5p N-(2-hydroxy-5-methylphenyl)-4-[[[2-(trifluoromethyl)pyridin-4-yl]amino]methyl]benzamide 54613415 NSC748715 sensitive
hsa-miR-26a-5p N-[(e)-[(4-methoxyphenyl)-pyridin-2-ylmethylidene]amino]pyridin-2-amine 9630043 NSC693622 sensitive
hsa-miR-26a-5p N-[(e)-1-pyrimidin-2-ylethylideneamino]-1,3-benzothiazol-2-amine 9572048 NSC693636 sensitive
hsa-miR-26a-5p N,N'-bis[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]butanediamide;hydrochloride 367397 NSC637124 resistant
hsa-miR-26a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-26a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-26a-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-26a-5p Docetaxel 148124 NSC628503 approved resistant Low Lung Cancer tissue
hsa-miR-26a-5p Docetaxel 148124 NSC628503 approved resistant Low Gastric Cancer tissue
hsa-miR-26a-5p Fluorouracil 3385 NSC19893 approved resistant High Colon Cancer cell line (KM12C)
hsa-miR-26a-5p Paclitaxel 36314 NSC125973 approved sensitive Low Breast Cancer cell line (MDA-MB-231, MCF-7, MDA-MB-435, MDA-MB-468, MCF-10A, 184A1)
hsa-miR-26a-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-26a-5p Imatinib 5291 NSC743414 approved sensitive High Chronic Myeloid Leukemia tissue
hsa-miR-26a-5p Platinum-based doublet chemotherapy resistant High Lung Adenocarcinoma tissue
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved resistant Low Ovarian Cancer tissue
hsa-miR-26a-5p Cetuximab resistant High Colon Cancer cell line
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved sensitive Low Gastric Cancer cell line (SGC7901)
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-26a-5p Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-26a-5p Mitoxantrone 4212 NSC279836 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-26a-5p Imatinib 5291 NSC743414 approved resistant High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-26a-5p Gefitinib 123631 NSC715055 approved resistant Low Non-Small Cell Lung Cancer cell line (A549, H520, SW900, H2170, PC-9)
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-26a-5p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (TAMR4)
hsa-miR-26a-5p Doxorubicin 31703 NSC123127 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-26a-5p Trastuzumab sensitive Low HER2-Positive Breast Cancer cell line (BT-474, HCC1954)
hsa-miR-26a-5p Fluorouracil 3385 NSC19893 approved sensitive High Colorectal Cancer cell line (DLD-1)
hsa-miR-26a-5p Docetaxel 148124 NSC628503 approved sensitive Low Lung Adenocarcinoma tissue and cell line (SPC-A1, H1299)
hsa-miR-26a-5p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-26a-5p Daunorubicin 30323 NSC82151 approved resistant High Acute Promyelocytic Leukemia cell line (HL60)
hsa-miR-26a-5p Tamoxifen 2733525 NSC180973 approved sensitive Low ER-Positive Breast Cancer cell line (MCF-7, T47D)
hsa-miR-26a-5p Paclitaxel 36314 NSC125973 approved sensitive Low Prostate Cancer cell line (PC-3-R)
hsa-miR-26a-5p Temozolomide 5394 NSC362856 approved resistant Low Glioblastoma cell line (U87MG, HEK293T)
hsa-miR-26a-5p Doxorubicin 31703 NSC123127 approved sensitive Low Hepatocellular Carcinoma cell line (Huh-7, SMMC-7721)
hsa-miR-26a-5p Dabrafenib 44462760 NSC764134 approved sensitive Low Melanoma cell line (A375 , MEL624)
hsa-miR-26a-5p Paclitaxel 36314 NSC125973 approved sensitive Low Osteosarcoma cell line (U-2-OS)
hsa-miR-26a-5p Bortezomib 387447 NSC681239 approved sensitive Low Multiple Myeloma cell line (RPMI8226, MM.1S, H929)
hsa-miR-26a-5p Melphalan 460612 NSC8806 approved sensitive Low Multiple Myeloma cell line (RPMI8226, MM.1S, H929)
hsa-miR-26a-5p Gemcitabine 60750 NSC613327 approved resistant Low Pancreatic Ductal Adenocarcinoma tissue
hsa-miR-26a-5p Paclitaxel 36314 NSC125973 approved sensitive High Endometrial Serous Carcinoma cell line (USPC1)
hsa-miR-26a-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer tissue
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780CP20)
hsa-miR-26a-5p Cetuximab sensitive Low Endometrial Cancer cell line (HEC-1A, RL-952)
hsa-miR-26a-5p Platinum 23939 resistant High High-Grade Serous Ovarian Cancer tissue
hsa-miR-26a-5p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-26a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-26a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-26a-5p Paclitaxel 36314 NSC125973 approved resistant cell line (HeyA8)
hsa-miR-26a-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CP20)
hsa-miR-26a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-26a-5p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-26a-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-26a-5p Gemcitabine 60750 NSC613327 approved resistant cell line (HuH28)
hsa-miR-26a-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-26a-5p Platinum-based doublet chemotherapy resistant tissue (lung adenocarcinoma)
hsa-miR-26a-5p Bortezomib 387447 NSC681239 approved resistant cell line (CCRF-CEM) (200 nM)
hsa-miR-26a-5p Bortezomib 387447 NSC681239 approved sensitive cell line (CCRF-CEM) (100 nM)
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (H460)
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)
hsa-miR-26a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (MDAH-2774)

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