miRTarBase - #MIRT004305


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pre-miRNA Information
pre-miRNA hsa-mir-98   
Genomic Coordinates chrX: 53556223 - 53556341
Synonyms MIRN98, hsa-mir-98, miR-98, MIR98
Description Homo sapiens miR-98 stem-loop
Comment This sequence is localised to chromosome X and was named mir-98-X in reference . The predicted stem-loop precursor sequence is clearly related to let-7.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-98-5p
Sequence 22| UGAGGUAGUAAGUUGUAUUGUU |43
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 11 X - 53556310 27229138, 20591823, 29165639 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1357591935 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol NCOA3   
Synonyms ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP
Description nuclear receptor coactivator 3
Transcript NM_001174087   
Other Transcripts NM_001174088 , NM_006534 , NM_181659   
Expression
Putative miRNA Targets on NCOA3
3'UTR of NCOA3
(miRNA target sites are highlighted)		 
>NCOA3|NM_001174087|3'UTR
   1 CATCTCTGCACCAGGACCTCTTAAGGAAACCACTGTACAAATGACACTGCACTAGGATTATTGGGAAGGAATCATTGTTC
  81 CAGGCATCCATCTTGGAAGAAAGGACCAGCTTTGAGCTCCATCAAGGGTATTTTAAGTGATGTCATTTGAGCAGGACTGG
 161 ATTTTAAGCCGAAGGGCAATATCTACGTGTTTTTCCCCCCTCCTTCTGCTGTGTATCATGGTGTTCAAAACAGAAATGTT
 241 TTTTGGCATTCCACCTCCTAGGGATATAATTCTGGAGACATGGAGTGTTACTGATCATAAAACTTTTGTGTCACTTTTTT
 321 CTGCCTTGCTAGCCAAAATCTCTTAAATACACGTAGGTGGGCCAGAGAACATTGGAAGAATCAAGAGAGATTAGAATATC
 401 TGGTTTCTCTAGTTGCAGTATTGGACAAAGAGCATAGTCCCAGCCTTCAGGTGTAGTAGTTCTGTGTTGACCCTTTGTCC
 481 AGTGGAATTGGTGATTCTGAATTGTCCTTTACTAATGGTGTTGAGTTGCTCTGTCCCTATTATTTGCCCTAGGCTTTCTC
 561 CTAATGAAGGTTTTCATTTGCCATTCATGTCCTGTAATACTTCACCTCCAGGAACTGTCATGGATGTCCAAATGGCTTTG
 641 CAGAAAGGAAATGAGATGACAGTATTTAATCGCAGCAGTAGCAAACTTTTCACATGCTAATGTGCAGCTGAGTGCACTTT
 721 ATTTAAAAAGAATGGATAAATGCAATATTCTTGAGGTCTTGAGGGAATAGTGAAACACATTCCTGGTTTTTGCCTACACT
 801 TACGTGTTAGACAAGAACTATGATTTTTTTTTTTAAAGTACTGGTGTCACCCTTTGCCTATATGGTAGAGCAATAATGCT
 881 TTTTAAAAATAAACTTCTGAAAACCCAAGGCCAGGTACTGCATTCTGAATCAGAATCTCGCAGTGTTTCTGTGAATAGAT
 961 TTTTTTGTAAATATGACCTTTAAGATATTGTATTATGTAAAATATGTATATACCTTTTTTTGTAGGTCACAACAACTCAT
1041 TTTTACAGAGTTTGTGAAGCTAAATATTTAACATTGTTGATTTCAGTAAGCTGTGTGGTGAGGCTACCAGTGGAAGAGAC
1121 ATCCCTTGACTTTTGTGGCCTGGGGGAGGGGTAGTGCTCCACAGCTTTTCCTTCCCCACCCCCCAGCCTTAGATGCCTCG
1201 CTCTTTTCAATCTCTTAATCTAAATGCTTTTTAAAGAGATTATTTGTTTAGATGTAGGCATTTTAATTTTTTAAAAATTC
1281 CTCTACCAGAACTAAGCACTTTGTTAATTTGGGGGGAAAGAATAGATATGGGGAAATAAACTTAAAAAAAAATCAGGAAT
1361 TTAAAAAAACGAGCAATTTGAAGAGAATCTTTTGGATTTTAAGCAGTCCGAAATAATAGCAATTCATGGGCTGTGTGTGT
1441 GTGTGTATGTGTGTGTGTGTGTGTGTATGTTTAATTATGTTACCTTTTCATCCCCTTTAGGAGCGTTTTCAGATTTTGGT
1521 TGCTAAGACCTGAATCCCATATTGAGATCTCGAGTAGAATCCTTGGTGTGGTTTCTGGTGTCTGCTCAGCTGTCCCCTCA
1601 TTCTACTAATGTGATGCTTTCATTATGTCCCTGTGGATTAGAATAGTGTCAGTTATTTCTTAAGTAACTCAGTACCCAGA
1681 ACAGCCAGTTTTACTGTGATTCAGAGCCACAGTCTAACTGAGCACCTTTTAAACCCCTCCCTCTTCTGCCCCCTACCACT
1761 TTTCTGCTGTTGCCTCTCTTTGACACCTGTTTTAGTCAGTTGGGAGGAAGGGAAAAATCAAGTTTAATTCCCTTTATCTG
1841 GGTTAATTCATTTGGTTCAAATAGTTGACGGAATTGGGTTTCTGAATGTCTGTGAATTTCAGAGGTCTCTGCTAGCCTTG
1921 GTATCATTTTCTAGCAATAACTGAGAGCCAGTTAATTTTAAGAATTTCACACATTTAGCCAATCTTTCTAGATGTCTCTG
2001 AAGGTAAGATCATTTAATATCTTTGATATGCTTACGAGTAAGTGAATCCTGATTATTTCCAGACCCACCACCAGAGTGGA
2081 TCTTATTTTCAAAGCAGTATAGACAATTATGAGTTTGCCCTCTTTCCCCTACCAAGTTCAAAATATATCTAAGAAAGATT
2161 GTAAATCCGAAAACTTCCATTGTAGTGGCCTGTGCTTTTCAGATAGTATACTCTCCTGTTTGGAGACAGAGGAAGAACCA
2241 GGTCAGTCTGTCTCTTTTTCAGCTCAATTGTATCTGACCCTTCTTTAAGTTATGTGTGTGGGGAGAAATAGAATGGTGCT
2321 CTTATCTTTCTTGACTTTAAAAAAATTATTAAAAACAAAAAAAAAATAAATTTTTTTGCAATCCTTTCCTCAGACCTGGC
2401 TCCAGGCTAACTGGAAGGCAGCACTCCCTTTTTTATATAGTAGAAAAATGAAGTTTATTATAAGTTTTTATATTTTCTAC
2481 TTGTTCATTTGGTGCAAACTCAAGATTTCTTTTAATAGGTGCAGTCTTTGAGATAATTTGTTTTTACCTGTATTGCCCTT
2561 TATCTTTTTTAGGTAATTCTTTGTACTCCTGCTGTCTACCTCTCCTCACACCCCAGCACCCCCCATTTTTTCAAACCTTG
2641 GTATCTGTTGGGTGAACAGTATAATCTTTTCATCTGCTTTTAGAATGTGGGATATTTCCAGTACCTACTTTTTTTTTTTT
2721 TTTTTGCTGAATCCAAAGATATATAAATAAAATATATATATTTTATAAAGATCAGAATGATATAAAGGAGATACATGTTT
2801 CTTCCTTTAAAAAATAAACGGAAGTTACATTGTTAATGTTCATATTATGATGCCACTTTTCTAAACTGCATCTGGATTGA
2881 AAGGTGTAAATATCAATAACAGTGCTACTTAGTTATCAGTATTTAATATCTGAGGTGAGTTGGGGGTATCTATATTAGGG
2961 GTAGGGTATTACAGAAGATAATTGGCTTGATGTCCTAGAAGTTCTTTGATCCAGAGGTGGGTGCAGCTGAAAGTAAACAG
3041 AATGGATTGCCAGTTACATGTATGCCTGCCCAGTTCCCTTTTTATTTGCAGAAGCTGTGAGTTTTGTTCACAATTAGGTT
3121 CCTAGGAGCAAAACCTCAAGGATTGATTTATTGTTTTCAACTCCAAGGCACACTGTTAATAAACGAGCAGGGTGTTTTCT
3201 CTCTTCCTTTCTAATATATGGAGTTTCGAAGAATAAAATATGAGAGCAATATTTAAATTCTCAGGAATTGACTTATACTC
3281 TTGAGAATGAATTCAGTTTCAATCAAGTTTACATTATGTTGCTTAAAAAAATAGAAATTATTCTTTATCTTGCAAAGAAT
3361 TGAAACCACATGAAATGACTTATGGGGGATGGTGAGCTGTGACTGCTTTGCTGACCATTTTGGATGTCATTGTAAATAAA
3441 GGTTTCTATTTAAAATTGGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuGUUAUGUUGAAUGAUGGAGu 5'
            :| | | :||  ||||||| 
Target 5' tgTACTCCTGCTGTCTACCTCt 3'
 2582 - 2603 152.00 -12.60
2 
miRNA  3' uuGUUA-UGUUGAAUGAUGGAgu 5'
            |||| |||:  |:||||:|  
Target 5' atCAATAACAG--TGCTACTTag 3'
 2892 - 2912 128.00 -10.40
3 
miRNA  3' uuguUAUGUUGA-AUGAUGGAGu 5'
              :| :||:| |::|||||: 
Target 5' gtatGTTTAATTATGTTACCTTt 3'
 1465 - 1487 126.00 -8.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30154093 7 COSMIC
COSN30506284 42 COSMIC
COSN26986111 69 COSMIC
COSN30182759 82 COSMIC
COSN30163171 88 COSMIC
COSN30514214 144 COSMIC
COSN26986110 150 COSMIC
COSN21368554 153 COSMIC
COSN26439846 157 COSMIC
COSN13866098 171 COSMIC
COSN30184031 173 COSMIC
COSN30184079 175 COSMIC
COSN20116506 183 COSMIC
COSN13866100 195 COSMIC
COSN18742969 195 COSMIC
COSN13866101 196 COSMIC
COSN18716767 246 COSMIC
COSN10016884 486 COSMIC
COSN24716719 495 COSMIC
COSN31481137 762 COSMIC
COSN5134330 804 COSMIC
COSN30173914 836 COSMIC
COSN17708369 973 COSMIC
COSN26576287 1173 COSMIC
COSN31550190 1184 COSMIC
COSN16850504 1205 COSMIC
COSN30013794 1228 COSMIC
COSN31520099 1237 COSMIC
COSN31584973 1261 COSMIC
COSN1874296 1415 COSMIC
COSN1874298 1424 COSMIC
COSN27982276 1446 COSMIC
COSN15661008 1448 COSMIC
COSN20116507 1467 COSMIC
COSN27346940 1490 COSMIC
COSN1249728 1717 COSMIC
COSN17846642 1944 COSMIC
COSN15660835 1980 COSMIC
COSN31514909 2037 COSMIC
COSN4780692 2120 COSMIC
COSN31541352 2207 COSMIC
COSN26566538 2247 COSMIC
COSN31572227 2275 COSMIC
COSN31523422 2318 COSMIC
COSN31532982 2367 COSMIC
COSN31595265 2413 COSMIC
COSN20093776 2500 COSMIC
COSN31518292 2638 COSMIC
COSN26648905 2684 COSMIC
COSN26551584 2688 COSMIC
COSN27320729 2725 COSMIC
COSN20116510 2726 COSMIC
COSN20116511 2726 COSMIC
COSN31513863 2739 COSMIC
COSN8000142 2949 COSMIC
COSN27176470 3040 COSMIC
COSN20116513 3134 COSMIC
COSN31548543 3238 COSMIC
COSN30169507 3269 COSMIC
COSN31607500 3327 COSMIC
COSN31609680 3358 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1193277936 4 dbSNP
rs545763445 14 dbSNP
rs372774941 16 dbSNP
rs779126997 17 dbSNP
rs1382279568 24 dbSNP
rs1288982007 29 dbSNP
rs1420362270 30 dbSNP
rs1163223942 32 dbSNP
rs72646207 41 dbSNP
rs754765634 44 dbSNP
rs1475776467 46 dbSNP
rs781170022 50 dbSNP
rs748096633 51 dbSNP
rs72646208 62 dbSNP
rs1186437620 67 dbSNP
rs1482927503 75 dbSNP
rs1251993528 77 dbSNP
rs1206825435 104 dbSNP
rs942247115 111 dbSNP
rs1036651258 113 dbSNP
rs1257714900 128 dbSNP
rs897994321 129 dbSNP
rs1468481628 131 dbSNP
rs1355916391 147 dbSNP
rs1302009745 152 dbSNP
rs1394225286 153 dbSNP
rs1377761287 157 dbSNP
rs1298274273 166 dbSNP
rs773241577 170 dbSNP
rs575463833 171 dbSNP
rs915248108 172 dbSNP
rs889219876 175 dbSNP
rs1007949716 177 dbSNP
rs1163239296 178 dbSNP
rs3092324 179 dbSNP
rs397839606 179 dbSNP
rs1339188286 180 dbSNP
rs978746126 180 dbSNP
rs3092417 186 dbSNP
rs6094766 187 dbSNP
rs1055319558 190 dbSNP
rs894869050 191 dbSNP
rs930389147 194 dbSNP
rs1009429764 195 dbSNP
rs572909502 196 dbSNP
rs886105835 197 dbSNP
rs1004588244 200 dbSNP
rs541654693 201 dbSNP
rs1441213796 204 dbSNP
rs1292121954 206 dbSNP
rs1397075046 206 dbSNP
rs1486407839 211 dbSNP
rs981925551 216 dbSNP
rs77034911 245 dbSNP
rs189567471 254 dbSNP
rs1379772811 255 dbSNP
rs984306949 260 dbSNP
rs576879510 264 dbSNP
rs143376484 267 dbSNP
rs1271193301 271 dbSNP
rs989525593 273 dbSNP
rs1261178003 275 dbSNP
rs1431613215 285 dbSNP
rs1350808694 287 dbSNP
rs181330239 288 dbSNP
rs1234441789 291 dbSNP
rs961073420 292 dbSNP
rs1372678699 293 dbSNP
rs1298826363 295 dbSNP
rs1386552997 297 dbSNP
rs1386154599 300 dbSNP
rs1291080250 302 dbSNP
rs756904105 305 dbSNP
rs1418442698 306 dbSNP
rs1292345133 307 dbSNP
rs374835226 313 dbSNP
rs1455688174 315 dbSNP
rs919516314 316 dbSNP
rs1198436724 317 dbSNP
rs1376116155 317 dbSNP
rs933445793 324 dbSNP
rs978145414 329 dbSNP
rs1051955117 335 dbSNP
rs1218638218 337 dbSNP
rs1487252994 340 dbSNP
rs1285267452 342 dbSNP
rs1210977672 349 dbSNP
rs1346585257 352 dbSNP
rs147170444 353 dbSNP
rs961001788 354 dbSNP
rs548567147 357 dbSNP
rs1298219774 363 dbSNP
rs139500644 368 dbSNP
rs1054312038 373 dbSNP
rs1340418546 376 dbSNP
rs1436596473 383 dbSNP
rs930839196 383 dbSNP
rs893804066 385 dbSNP
rs1009532830 389 dbSNP
rs1400161625 409 dbSNP
rs548508082 410 dbSNP
rs1359806947 425 dbSNP
rs1048836015 427 dbSNP
rs1405531991 429 dbSNP
rs1375048318 434 dbSNP
rs749939730 437 dbSNP
rs1476754840 452 dbSNP
rs1262375887 454 dbSNP
rs1188592116 460 dbSNP
rs1343123979 464 dbSNP
rs1443578353 465 dbSNP
rs560394083 474 dbSNP
rs72646209 485 dbSNP
rs879917843 486 dbSNP
rs1307272511 487 dbSNP
rs1199478765 495 dbSNP
rs1318424830 506 dbSNP
rs1339635509 506 dbSNP
rs1259636264 508 dbSNP
rs779718716 509 dbSNP
rs940334366 513 dbSNP
rs1241610026 515 dbSNP
rs866447867 517 dbSNP
rs1040056072 518 dbSNP
rs552306036 520 dbSNP
rs1294369548 527 dbSNP
rs1417195361 530 dbSNP
rs1338723239 533 dbSNP
rs1353580628 538 dbSNP
rs1033505507 547 dbSNP
rs115501901 548 dbSNP
rs1005299988 549 dbSNP
rs1271077549 554 dbSNP
rs1398898459 565 dbSNP
rs1487553630 571 dbSNP
rs1017098504 572 dbSNP
rs1463817566 581 dbSNP
rs1422663596 587 dbSNP
rs45610642 590 dbSNP
rs892968721 595 dbSNP
rs1421163940 596 dbSNP
rs1186186808 598 dbSNP
rs1437974642 606 dbSNP
rs1176517126 608 dbSNP
rs1011397103 611 dbSNP
rs769064038 622 dbSNP
rs1425171070 630 dbSNP
rs1165412600 650 dbSNP
rs1274220797 651 dbSNP
rs972404146 672 dbSNP
rs919485341 673 dbSNP
rs557576342 675 dbSNP
rs1456968661 677 dbSNP
rs1239840072 680 dbSNP
rs1379232110 680 dbSNP
rs781595793 701 dbSNP
rs550293555 705 dbSNP
rs1446364366 710 dbSNP
rs1399217998 720 dbSNP
rs1326309672 721 dbSNP
rs1406918970 723 dbSNP
rs1035036337 731 dbSNP
rs954923385 735 dbSNP
rs1444177379 736 dbSNP
rs113935223 738 dbSNP
rs1381656185 739 dbSNP
rs961208034 740 dbSNP
rs757628463 743 dbSNP
rs1438667251 744 dbSNP
rs1307482558 746 dbSNP
rs1450298477 747 dbSNP
rs991069450 753 dbSNP
rs988156270 754 dbSNP
rs910710310 766 dbSNP
rs1247276367 780 dbSNP
rs748498017 781 dbSNP
rs1307207578 796 dbSNP
rs1320510570 802 dbSNP
rs1371964086 804 dbSNP
rs569112996 805 dbSNP
rs536435823 808 dbSNP
rs185024445 816 dbSNP
rs573073843 819 dbSNP
rs1322768735 824 dbSNP
rs1347905913 824 dbSNP
rs984982259 824 dbSNP
rs915341513 829 dbSNP
rs1252012997 836 dbSNP
rs1438608962 844 dbSNP
rs907596234 845 dbSNP
rs1481721352 851 dbSNP
rs945357995 855 dbSNP
rs1246525394 859 dbSNP
rs1042353320 861 dbSNP
rs940462763 864 dbSNP
rs1489546459 865 dbSNP
rs35259021 867 dbSNP
rs770047112 868 dbSNP
rs1392114693 871 dbSNP
rs1431533159 872 dbSNP
rs1166711223 873 dbSNP
rs1217720784 875 dbSNP
rs1365164547 885 dbSNP
rs1274005388 904 dbSNP
rs552539526 905 dbSNP
rs1445027461 907 dbSNP
rs1003454568 912 dbSNP
rs1342283630 913 dbSNP
rs773481223 915 dbSNP
rs1411521581 916 dbSNP
rs570651593 917 dbSNP
rs573895935 919 dbSNP
rs369028562 936 dbSNP
rs558275694 940 dbSNP
rs763174545 941 dbSNP
rs144538511 950 dbSNP
rs544019069 956 dbSNP
rs1011346280 957 dbSNP
rs994415873 959 dbSNP
rs1041565841 960 dbSNP
rs1486016748 978 dbSNP
rs542919435 989 dbSNP
rs1218994612 991 dbSNP
rs1319752132 997 dbSNP
rs1276148729 999 dbSNP
rs999620425 1004 dbSNP
rs149248173 1007 dbSNP
rs1304061125 1009 dbSNP
rs993941943 1010 dbSNP
rs1029317555 1012 dbSNP
rs1445229333 1013 dbSNP
rs1358214168 1014 dbSNP
rs551088645 1015 dbSNP
rs955056863 1015 dbSNP
rs1286379510 1023 dbSNP
rs1377587872 1024 dbSNP
rs1228293001 1028 dbSNP
rs1296336158 1029 dbSNP
rs371819589 1033 dbSNP
rs1170529861 1047 dbSNP
rs960690091 1070 dbSNP
rs1416640472 1075 dbSNP
rs148491872 1090 dbSNP
rs542043111 1093 dbSNP
rs1482997772 1096 dbSNP
rs1233607733 1099 dbSNP
rs1200759767 1103 dbSNP
rs117360582 1107 dbSNP
rs1255947522 1110 dbSNP
rs1217840562 1114 dbSNP
rs990075664 1117 dbSNP
rs1801981 1138 dbSNP
rs1026254751 1148 dbSNP
rs1023877487 1152 dbSNP
rs888636028 1153 dbSNP
rs915436443 1173 dbSNP
rs945453042 1174 dbSNP
rs373321636 1180 dbSNP
rs546390148 1181 dbSNP
rs984926360 1182 dbSNP
rs1015099472 1183 dbSNP
rs1482865222 1184 dbSNP
rs1458796804 1185 dbSNP
rs72646210 1186 dbSNP
rs760641688 1189 dbSNP
rs895067448 1195 dbSNP
rs1420952096 1198 dbSNP
rs546430844 1200 dbSNP
rs941178368 1201 dbSNP
rs1237850680 1204 dbSNP
rs1197779328 1215 dbSNP
rs1267083161 1216 dbSNP
rs1038191981 1220 dbSNP
rs11699879 1223 dbSNP
rs1429532744 1233 dbSNP
rs993907580 1237 dbSNP
rs985782640 1240 dbSNP
rs1336521860 1243 dbSNP
rs780230593 1251 dbSNP
rs6125065 1254 dbSNP
rs1387644026 1267 dbSNP
rs1393331448 1268 dbSNP
rs550331893 1273 dbSNP
rs1289974351 1276 dbSNP
rs568544302 1286 dbSNP
rs146502858 1288 dbSNP
rs1343009795 1295 dbSNP
rs1041903432 1297 dbSNP
rs1418016987 1298 dbSNP
rs1017833056 1310 dbSNP
rs1379906259 1310 dbSNP
rs1199867717 1312 dbSNP
rs1216860862 1313 dbSNP
rs1277702205 1319 dbSNP
rs965315107 1322 dbSNP
rs903014743 1324 dbSNP
rs989721919 1330 dbSNP
rs1490156639 1335 dbSNP
rs1022414217 1336 dbSNP
rs1218147533 1337 dbSNP
rs1276187300 1337 dbSNP
rs966888505 1343 dbSNP
rs1056541396 1344 dbSNP
rs202154300 1344 dbSNP
rs1333138477 1345 dbSNP
rs978108178 1348 dbSNP
rs77268998 1353 dbSNP
rs928061466 1354 dbSNP
rs939339322 1363 dbSNP
rs1311401897 1364 dbSNP
rs1398165521 1368 dbSNP
rs1359987312 1370 dbSNP
rs72646211 1371 dbSNP
rs1015629989 1372 dbSNP
rs1173687330 1380 dbSNP
rs1480020184 1384 dbSNP
rs1487298778 1386 dbSNP
rs1195754427 1388 dbSNP
rs566617812 1402 dbSNP
rs941262648 1410 dbSNP
rs1200586625 1413 dbSNP
rs1346650135 1417 dbSNP
rs1038327388 1419 dbSNP
rs1269025245 1423 dbSNP
rs896986398 1425 dbSNP
rs11699902 1427 dbSNP
rs1398730417 1429 dbSNP
rs1187638177 1432 dbSNP
rs1372475120 1432 dbSNP
rs1400318871 1432 dbSNP
rs1424105917 1432 dbSNP
rs1443703430 1432 dbSNP
rs1476785961 1432 dbSNP
rs372177830 1432 dbSNP
rs914242484 1432 dbSNP
rs947094058 1432 dbSNP
rs953150679 1432 dbSNP
rs985726703 1432 dbSNP
rs1423421623 1433 dbSNP
rs1202645091 1434 dbSNP
rs1260421480 1434 dbSNP
rs1458464982 1434 dbSNP
rs1217239831 1436 dbSNP
rs1414259187 1438 dbSNP
rs1160364507 1440 dbSNP
rs1050796390 1442 dbSNP
rs924553242 1444 dbSNP
rs938511926 1444 dbSNP
rs1362982598 1445 dbSNP
rs1057380172 1446 dbSNP
rs1447820832 1446 dbSNP
rs6094767 1446 dbSNP
rs11473242 1448 dbSNP
rs144164627 1448 dbSNP
rs6090710 1448 dbSNP
rs769156345 1448 dbSNP
rs775674695 1448 dbSNP
rs896545709 1448 dbSNP
rs1182548533 1450 dbSNP
rs948124053 1454 dbSNP
rs1045046167 1466 dbSNP
rs371110073 1468 dbSNP
rs1245348896 1494 dbSNP
rs1398743965 1502 dbSNP
rs1006665803 1505 dbSNP
rs765141394 1506 dbSNP
rs575492858 1510 dbSNP
rs1273301351 1513 dbSNP
rs181794078 1514 dbSNP
rs1379393021 1519 dbSNP
rs868681788 1524 dbSNP
rs72646212 1527 dbSNP
rs997670486 1532 dbSNP
rs750033522 1537 dbSNP
rs1030469862 1541 dbSNP
rs1022506838 1552 dbSNP
rs191666426 1553 dbSNP
rs539104635 1557 dbSNP
rs1291806241 1569 dbSNP
rs1381714938 1573 dbSNP
rs1490700608 1582 dbSNP
rs1469911239 1584 dbSNP
rs537428355 1585 dbSNP
rs1247675604 1590 dbSNP
rs1035086461 1606 dbSNP
rs1201523556 1608 dbSNP
rs961055304 1609 dbSNP
rs990948272 1613 dbSNP
rs555715361 1622 dbSNP
rs1291777041 1623 dbSNP
rs557748651 1637 dbSNP
rs1245758185 1644 dbSNP
rs977516612 1650 dbSNP
rs1284071541 1651 dbSNP
rs916561162 1661 dbSNP
rs1223460893 1663 dbSNP
rs772734287 1665 dbSNP
rs962741746 1669 dbSNP
rs1275199521 1671 dbSNP
rs1470337007 1673 dbSNP
rs1178110372 1676 dbSNP
rs973944500 1680 dbSNP
rs918513463 1683 dbSNP
rs992644235 1683 dbSNP
rs915748401 1690 dbSNP
rs1382591343 1691 dbSNP
rs1418359888 1692 dbSNP
rs929765692 1692 dbSNP
rs1045164314 1695 dbSNP
rs1050899616 1699 dbSNP
rs1268730872 1700 dbSNP
rs942022355 1702 dbSNP
rs1366197029 1724 dbSNP
rs1489289579 1726 dbSNP
rs1261157256 1740 dbSNP
rs1215220885 1753 dbSNP
rs1407146546 1754 dbSNP
rs1321729910 1756 dbSNP
rs1321151517 1761 dbSNP
rs1330715705 1768 dbSNP
rs1282509502 1777 dbSNP
rs747964542 1794 dbSNP
rs1342344111 1798 dbSNP
rs1443256849 1799 dbSNP
rs865784783 1801 dbSNP
rs1359369566 1811 dbSNP
rs942438936 1815 dbSNP
rs998178997 1818 dbSNP
rs1039497950 1825 dbSNP
rs1171953899 1825 dbSNP
rs1479078352 1839 dbSNP
rs1422161638 1841 dbSNP
rs1052007232 1856 dbSNP
rs892754967 1857 dbSNP
rs574211941 1861 dbSNP
rs1208318710 1869 dbSNP
rs183437441 1870 dbSNP
rs541484234 1871 dbSNP
rs554077156 1873 dbSNP
rs187155333 1875 dbSNP
rs755476740 1879 dbSNP
rs1438010684 1881 dbSNP
rs772800423 1887 dbSNP
rs6094768 1890 dbSNP
rs1213418971 1891 dbSNP
rs1031763929 1896 dbSNP
rs1285551742 1908 dbSNP
rs1450042004 1910 dbSNP
rs959942004 1912 dbSNP
rs1178481315 1917 dbSNP
rs960938305 1940 dbSNP
rs1353259009 1943 dbSNP
rs1170363580 1949 dbSNP
rs796834693 1952 dbSNP
rs1416074632 1972 dbSNP
rs1181873240 1976 dbSNP
rs1161500038 1978 dbSNP
rs1444202891 1979 dbSNP
rs72646213 1983 dbSNP
rs1410697952 1984 dbSNP
rs1333631217 1988 dbSNP
rs1023720249 1994 dbSNP
rs983977189 2005 dbSNP
rs377697437 2010 dbSNP
rs962666812 2013 dbSNP
rs974081697 2018 dbSNP
rs1321747417 2019 dbSNP
rs942123636 2025 dbSNP
rs918616364 2031 dbSNP
rs1309609079 2032 dbSNP
rs371320520 2036 dbSNP
rs919248540 2054 dbSNP
rs531636287 2061 dbSNP
rs1458843259 2064 dbSNP
rs2664536 2070 dbSNP
rs1424159617 2071 dbSNP
rs942551961 2075 dbSNP
rs562025450 2086 dbSNP
rs1051951666 2087 dbSNP
rs529414116 2088 dbSNP
rs144185862 2097 dbSNP
rs1457085186 2107 dbSNP
rs1488751203 2111 dbSNP
rs1248455782 2117 dbSNP
rs1219607784 2118 dbSNP
rs1007656654 2129 dbSNP
rs1043216868 2130 dbSNP
rs1241897652 2133 dbSNP
rs914341346 2140 dbSNP
rs1444595285 2147 dbSNP
rs868787472 2152 dbSNP
rs1306693206 2156 dbSNP
rs947031719 2157 dbSNP
rs1387775765 2160 dbSNP
rs563905180 2169 dbSNP
rs1447774877 2170 dbSNP
rs3746480 2170 dbSNP
rs1404338462 2179 dbSNP
rs1041345196 2181 dbSNP
rs778114954 2182 dbSNP
rs999724442 2188 dbSNP
rs566594346 2189 dbSNP
rs1056756261 2200 dbSNP
rs896607477 2203 dbSNP
rs1363483692 2212 dbSNP
rs1012424554 2214 dbSNP
rs527468366 2215 dbSNP
rs898599465 2216 dbSNP
rs1431280106 2228 dbSNP
rs1433619712 2228 dbSNP
rs552218307 2229 dbSNP
rs1490028691 2232 dbSNP
rs14189 2234 dbSNP
rs895466180 2240 dbSNP
rs12273 2242 dbSNP
rs1022871730 2255 dbSNP
rs987083001 2255 dbSNP
rs1314312724 2256 dbSNP
rs1019537678 2268 dbSNP
rs1404117102 2271 dbSNP
rs964192221 2273 dbSNP
rs770906149 2275 dbSNP
rs1300082428 2279 dbSNP
rs1384513972 2285 dbSNP
rs1333438341 2286 dbSNP
rs1431186559 2291 dbSNP
rs975292230 2291 dbSNP
rs1174055572 2293 dbSNP
rs1480049457 2309 dbSNP
rs1401289433 2310 dbSNP
rs1017187874 2314 dbSNP
rs1426231727 2318 dbSNP
rs963456262 2320 dbSNP
rs972550136 2322 dbSNP
rs569753342 2323 dbSNP
rs1316883010 2324 dbSNP
rs914430891 2330 dbSNP
rs1256905246 2336 dbSNP
rs1347596286 2339 dbSNP
rs555750290 2345 dbSNP
rs1256060668 2346 dbSNP
rs1225263610 2348 dbSNP
rs977172767 2350 dbSNP
rs1313643667 2351 dbSNP
rs1397980771 2357 dbSNP
rs1404231493 2357 dbSNP
rs1469153188 2357 dbSNP
rs72646214 2357 dbSNP
rs910774182 2357 dbSNP
rs943629379 2361 dbSNP
rs1195897880 2365 dbSNP
rs1043165799 2367 dbSNP
rs1372024819 2368 dbSNP
rs904689597 2368 dbSNP
rs924275737 2370 dbSNP
rs1261165594 2371 dbSNP
rs938363778 2371 dbSNP
rs1240960388 2377 dbSNP
rs1183356885 2382 dbSNP
rs1053268805 2385 dbSNP
rs1275645576 2391 dbSNP
rs533048404 2392 dbSNP
rs774386129 2398 dbSNP
rs563500321 2409 dbSNP
rs896747286 2420 dbSNP
rs948195702 2423 dbSNP
rs2179591 2424 dbSNP
rs536607011 2426 dbSNP
rs11547289 2428 dbSNP
rs1377402668 2434 dbSNP
rs1421479414 2436 dbSNP
rs1408119960 2438 dbSNP
rs776375537 2450 dbSNP
rs1016885696 2454 dbSNP
rs1426073947 2454 dbSNP
rs1382948251 2461 dbSNP
rs572585213 2461 dbSNP
rs1234936040 2462 dbSNP
rs1180153506 2464 dbSNP
rs1339301971 2469 dbSNP
rs540001036 2470 dbSNP
rs151069803 2471 dbSNP
rs887075009 2472 dbSNP
rs1357374339 2475 dbSNP
rs774931456 2480 dbSNP
rs1329061205 2484 dbSNP
rs186687440 2489 dbSNP
rs1019928067 2493 dbSNP
rs963977525 2500 dbSNP
rs954804398 2504 dbSNP
rs1439836220 2509 dbSNP
rs1335082838 2510 dbSNP
rs975763553 2514 dbSNP
rs987396849 2517 dbSNP
rs1363206600 2520 dbSNP
rs1255814047 2521 dbSNP
rs910553419 2525 dbSNP
rs775936812 2546 dbSNP
rs1419892023 2548 dbSNP
rs943410137 2551 dbSNP
rs761819268 2555 dbSNP
rs1469956970 2558 dbSNP
rs979418762 2558 dbSNP
rs926256910 2561 dbSNP
rs1021404071 2562 dbSNP
rs1202265896 2565 dbSNP
rs1489865567 2565 dbSNP
rs140978561 2573 dbSNP
rs968560162 2574 dbSNP
rs977099015 2579 dbSNP
rs1448954114 2589 dbSNP
rs924372228 2594 dbSNP
rs1283906895 2597 dbSNP
rs1221800932 2599 dbSNP
rs1349697172 2600 dbSNP
rs1283807881 2601 dbSNP
rs938317718 2608 dbSNP
rs934808667 2613 dbSNP
rs191502116 2614 dbSNP
rs1457095526 2618 dbSNP
rs200283719 2619 dbSNP
rs1315789698 2620 dbSNP
rs1269724581 2621 dbSNP
rs1403383307 2626 dbSNP
rs915584545 2626 dbSNP
rs1431706949 2627 dbSNP
rs1429286501 2630 dbSNP
rs542386106 2639 dbSNP
rs765088204 2640 dbSNP
rs1421383767 2645 dbSNP
rs1156790289 2652 dbSNP
rs1359274423 2653 dbSNP
rs1457963769 2657 dbSNP
rs1294834467 2658 dbSNP
rs1388096406 2659 dbSNP
rs898625586 2662 dbSNP
rs1005251166 2665 dbSNP
rs762495908 2667 dbSNP
rs1300960464 2670 dbSNP
rs1214574157 2674 dbSNP
rs574077498 2677 dbSNP
rs1363491007 2687 dbSNP
rs1038674047 2703 dbSNP
rs1383123427 2705 dbSNP
rs897086940 2705 dbSNP
rs978053774 2708 dbSNP
rs1185138323 2709 dbSNP
rs1320859949 2709 dbSNP
rs1459815944 2709 dbSNP
rs1468622969 2709 dbSNP
rs200394945 2709 dbSNP
rs377097381 2709 dbSNP
rs57501886 2709 dbSNP
rs878969991 2709 dbSNP
rs1242869620 2710 dbSNP
rs1307708774 2712 dbSNP
rs1353696880 2717 dbSNP
rs1262388021 2725 dbSNP
rs1205161811 2726 dbSNP
rs1222373012 2727 dbSNP
rs1267340431 2729 dbSNP
rs1487602707 2730 dbSNP
rs1213549765 2732 dbSNP
rs1209489155 2734 dbSNP
rs1238500874 2736 dbSNP
rs1316735823 2739 dbSNP
rs1441319021 2739 dbSNP
rs994377125 2739 dbSNP
rs1450825734 2743 dbSNP
rs369146528 2745 dbSNP
rs1382544588 2750 dbSNP
rs1029504412 2752 dbSNP
rs1299197690 2752 dbSNP
rs1444968178 2752 dbSNP
rs931477107 2754 dbSNP
rs954751002 2756 dbSNP
rs1176615849 2759 dbSNP
rs1379597805 2761 dbSNP
rs1008931242 2770 dbSNP
rs1255187243 2770 dbSNP
rs1177610583 2771 dbSNP
rs1481572684 2782 dbSNP
rs1231163921 2784 dbSNP
rs72646216 2789 dbSNP
rs1359543339 2798 dbSNP
rs887210750 2804 dbSNP
rs1243351588 2809 dbSNP
rs1358351056 2817 dbSNP
rs1166242004 2818 dbSNP
rs1308124156 2820 dbSNP
rs1366228275 2820 dbSNP
rs1008754589 2821 dbSNP
rs1298106224 2821 dbSNP
rs1405585306 2827 dbSNP
rs1041040125 2839 dbSNP
rs1402112602 2841 dbSNP
rs926175987 2846 dbSNP
rs899863921 2862 dbSNP
rs996771834 2865 dbSNP
rs1364666662 2866 dbSNP
rs989352103 2870 dbSNP
rs546465696 2886 dbSNP
rs750268774 2897 dbSNP
rs1181405432 2898 dbSNP
rs1270389562 2899 dbSNP
rs1490357336 2899 dbSNP
rs1219674168 2903 dbSNP
rs998658546 2912 dbSNP
rs559777692 2913 dbSNP
rs1260957120 2919 dbSNP
rs1218299445 2943 dbSNP
rs950236642 2947 dbSNP
rs1306849704 2953 dbSNP
rs1044156398 2955 dbSNP
rs1347977598 2963 dbSNP
rs1376767242 2966 dbSNP
rs1031359242 2970 dbSNP
rs927052273 2973 dbSNP
rs1229424091 2978 dbSNP
rs1314877030 2980 dbSNP
rs1320009112 2983 dbSNP
rs1290860742 2989 dbSNP
rs1455118482 2991 dbSNP
rs1343240210 2994 dbSNP
rs940999911 2998 dbSNP
rs959797228 3003 dbSNP
rs533242267 3005 dbSNP
rs1431447688 3009 dbSNP
rs993022417 3016 dbSNP
rs531226007 3021 dbSNP
rs1459304000 3033 dbSNP
rs1196501772 3035 dbSNP
rs1237376948 3039 dbSNP
rs1483510002 3041 dbSNP
rs1206548523 3047 dbSNP
rs552159715 3048 dbSNP
rs559959730 3049 dbSNP
rs183904698 3054 dbSNP
rs1267860909 3059 dbSNP
rs1204783095 3064 dbSNP
rs1410903018 3066 dbSNP
rs377183055 3067 dbSNP
rs564087473 3070 dbSNP
rs1222911723 3072 dbSNP
rs1170847995 3078 dbSNP
rs531505941 3079 dbSNP
rs920190736 3082 dbSNP
rs1168926962 3104 dbSNP
rs1361579153 3105 dbSNP
rs931447624 3114 dbSNP
rs1407675240 3119 dbSNP
rs1051490444 3124 dbSNP
rs398088140 3130 dbSNP
rs72646217 3130 dbSNP
rs1174219844 3138 dbSNP
rs1373127577 3141 dbSNP
rs1465062702 3141 dbSNP
rs1194743004 3142 dbSNP
rs1426362455 3144 dbSNP
rs1247090936 3146 dbSNP
rs1449319824 3148 dbSNP
rs890948179 3150 dbSNP
rs1241795340 3151 dbSNP
rs1200409955 3152 dbSNP
rs1340746884 3156 dbSNP
rs72646218 3161 dbSNP
rs775655794 3165 dbSNP
rs1377713817 3173 dbSNP
rs908734217 3173 dbSNP
rs528584384 3174 dbSNP
rs1017626953 3175 dbSNP
rs1453044378 3176 dbSNP
rs567759784 3185 dbSNP
rs1334499270 3189 dbSNP
rs944127393 3191 dbSNP
rs1395349873 3193 dbSNP
rs1397208302 3194 dbSNP
rs878897617 3197 dbSNP
rs1169130418 3198 dbSNP
rs764033983 3206 dbSNP
rs1414231945 3207 dbSNP
rs762676016 3212 dbSNP
rs1278970042 3217 dbSNP
rs1446774365 3228 dbSNP
rs565949716 3228 dbSNP
rs899790581 3229 dbSNP
rs996807686 3232 dbSNP
rs1438898312 3235 dbSNP
rs1253359648 3236 dbSNP
rs72646219 3261 dbSNP
rs150254333 3263 dbSNP
rs1292709328 3274 dbSNP
rs1357604386 3277 dbSNP
rs1257130537 3279 dbSNP
rs989075568 3282 dbSNP
rs1330818265 3283 dbSNP
rs1312563774 3284 dbSNP
rs1389135192 3285 dbSNP
rs147713754 3292 dbSNP
rs998751820 3295 dbSNP
rs539126815 3298 dbSNP
rs1303285677 3299 dbSNP
rs1031452496 3302 dbSNP
rs1482916538 3305 dbSNP
rs1383074183 3315 dbSNP
rs368883109 3325 dbSNP
rs980284275 3325 dbSNP
rs1193723105 3330 dbSNP
rs1013966965 3332 dbSNP
rs1023145328 3333 dbSNP
rs969721965 3336 dbSNP
rs941125973 3337 dbSNP
rs1269655407 3341 dbSNP
rs1419167146 3341 dbSNP
rs1489916820 3344 dbSNP
rs973085987 3344 dbSNP
rs1415397966 3345 dbSNP
rs1178761416 3346 dbSNP
rs1351170848 3347 dbSNP
rs1357905735 3354 dbSNP
rs1434684408 3358 dbSNP
rs920283730 3361 dbSNP
rs576659945 3370 dbSNP
rs1283364062 3371 dbSNP
rs766172246 3372 dbSNP
rs984490713 3373 dbSNP
rs1347699529 3376 dbSNP
rs1322485229 3380 dbSNP
rs1387561434 3384 dbSNP
rs908706658 3384 dbSNP
rs1398314235 3386 dbSNP
rs944204709 3388 dbSNP
rs1472547363 3397 dbSNP
rs751071676 3400 dbSNP
rs1479499700 3405 dbSNP
rs754501609 3406 dbSNP
rs932630944 3408 dbSNP
rs1194197247 3425 dbSNP
rs138887927 3430 dbSNP
rs1286052073 3431 dbSNP
rs1043019925 3433 dbSNP
rs1347013892 3437 dbSNP
rs1217271034 3447 dbSNP
rs1287462113 3449 dbSNP
rs1263682273 3451 dbSNP
rs1224748075 3452 dbSNP
rs1364900021 3452 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Article - Gennarino VA; Sardiello M; Avellino R; et al.
- Genome research, 2009
MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression by inducing RNA cleavage or translational inhibition. Most human miRNAs are intragenic and are transcribed as part of their hosting transcription units. We hypothesized that the expression profiles of miRNA host genes and of their targets are inversely correlated and devised a novel procedure, HOCTAR (host gene oppositely correlated targets), which ranks predicted miRNA target genes based on their anti-correlated expression behavior relative to their respective miRNA host genes. HOCTAR is the first tool for systematic miRNA target prediction that utilizes the same set of microarray experiments to monitor the expression of both miRNAs (through their host genes) and candidate targets. We applied the procedure to 178 human intragenic miRNAs and found that it performs better than currently available prediction softwares in pinpointing previously validated miRNA targets. The high-scoring HOCTAR predicted targets were enriched in Gene Ontology categories, which were consistent with previously published data, as in the case of miR-106b and miR-93. By means of overexpression and loss-of-function assays, we also demonstrated that HOCTAR is efficient in predicting novel miRNA targets and we identified, by microarray and qRT-PCR procedures, 34 and 28 novel targets for miR-26b and miR-98, respectively. Overall, we believe that the use of HOCTAR significantly reduces the number of candidate miRNA targets to be tested compared to the procedures based solely on target sequence recognition. Finally, our data further confirm that miRNAs have a significant impact on the mRNA levels of most of their targets.
LinkOut: [PMID: 19088304]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions MCF-7
Disease 8202.0;
Tools used in this research TargetScan
Original Description (Extracted from the article) ... "E2 induced the expression of eight Let-7 family members ...

- Bhat-Nakshatri P; Wang G; Collins NR; et al., 2009, Nucleic acids research.

Article - Bhat-Nakshatri P; Wang G; Collins NR; et al.
- Nucleic acids research, 2009
Estradiol (E2) regulates gene expression at the transcriptional level by functioning as a ligand for estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta). E2-inducible proteins c-Myc and E2Fs are required for optimal ERalpha activity and secondary estrogen responses, respectively. We show that E2 induces 21 microRNAs and represses seven microRNAs in MCF-7 breast cancer cells; these microRNAs have the potential to control 420 E2-regulated and 757 non-E2-regulated mRNAs at the post-transcriptional level. The serine/threonine kinase, AKT, alters E2-regulated expression of microRNAs. E2 induced the expression of eight Let-7 family members, miR-98 and miR-21 microRNAs; these microRNAs reduced the levels of c-Myc and E2F2 proteins. Dicer, a ribonuclease III enzyme required for microRNA processing, is also an E2-inducible gene. Several E2-regulated microRNA genes are associated with ERalpha-binding sites or located in the intragenic region of estrogen-regulated genes. We propose that the clinical course of ERalpha-positive breast cancers is dependent on the balance between E2-regulated tumor-suppressor microRNAs and oncogenic microRNAs. Additionally, our studies reveal a negative-regulatory loop controlling E2 response through microRNAs as well as differences in E2-induced transcriptome and proteome.
LinkOut: [PMID: 19528081]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuGUUAUGUUGAAUGAUGGAGu 5'
            :| | | :||  ||||||| 
Target 5' --UACUCCUGCUGUCUACCUCu 3'
 		1 - 20
Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177600. RNA binding protein: AGO2. Condition:p53_V_Ago_CLIP_2_2 PAR-CLIP data was present in ERX177606. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_2_8 PAR-CLIP data was present in ERX177612. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_2 PAR-CLIP data was present in ERX177613. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_3_3 PAR-CLIP data was present in ERX177618. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_3_8 PAR-CLIP data was present in ERX177624. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_2 PAR-CLIP data was present in ERX177625. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_3 PAR-CLIP data was present in ERX177630. RNA binding protein: AGO2. Condition:KO_V_AGO_CLIP_4_8 PAR-CLIP data was present in ERX177633. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_11 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000341724.6 | 3UTR | UACUCCUGCUGUCUACCUCUCCUCACACCCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21032 Prostate cancer 0.34 8.3e-4 0.342 7.8e-4 83 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.579 3.7e-3 0.559 5.2e-3 20 Click to see details
GSE28544 Breast cancer -0.522 4.4e-3 -0.714 4.5e-5 24 Click to see details
GSE28260 Renal cortex and medulla -0.628 1.1e-2 -0.637 9.6e-3 13 Click to see details
GSE17498 Multiple myeloma 0.335 1.7e-2 0.124 2.2e-1 40 Click to see details
GSE17306 Multiple myeloma -0.276 2.7e-2 -0.245 4.5e-2 49 Click to see details
GSE19783 ER+ ER+ breast cancer 0.353 6.3e-2 0.343 6.9e-2 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.308 6.7e-2 0.331 5.3e-2 25 Click to see details
GSE26953 Aortic valvular endothelial cells 0.295 8.1e-2 0.217 1.5e-1 24 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.265 1.0e-1 0.090 3.3e-1 25 Click to see details
GSE14794 Lymphoblastoid cells 0.125 1.2e-1 0.133 1.1e-1 90 Click to see details
GSE27834 Pluripotent stem cells 0.247 1.8e-1 0.403 6.1e-2 16 Click to see details
GSE19783 ER- ER- breast cancer -0.071 2.7e-1 -0.048 3.4e-1 79 Click to see details
GSE32688 Pancreatic cancer 0.111 2.7e-1 0.077 3.4e-1 32 Click to see details
GSE38226 Liver fibrosis -0.136 2.8e-1 -0.177 2.2e-1 21 Click to see details
GSE42095 Differentiated embryonic stem cells -0.091 3.4e-1 0.046 4.2e-1 23 Click to see details
GSE21687 Ependynoma primary tumors -0.034 3.9e-1 -0.029 4.1e-1 64 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.032 4.7e-1 0.283 2.3e-1 9 Click to see details
GSE19350 CNS germ cell tumors 0.026 4.7e-1 0.070 4.1e-1 12 Click to see details
GSE21849 B cell lymphoma -0.007 4.9e-1 0.062 3.7e-1 29 Click to see details
GSE19536 Breast cancer -0.002 4.9e-1 -0.001 5.0e-1 100 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BLCA 0.531 0.01 0.302 0.11 18 Click to see details
UCEC 0.503 0.01 0.530 0.01 19 Click to see details
STAD 0.23 0.1 0.269 0.07 32 Click to see details
PAAD -0.673 0.16 -0.400 0.3 4 Click to see details
KICH -0.202 0.17 -0.180 0.19 25 Click to see details
LUSC 0.157 0.17 0.050 0.38 38 Click to see details
CHOL -0.311 0.21 -0.267 0.24 9 Click to see details
ESCA 0.251 0.23 0.227 0.25 11 Click to see details
PCPG 0.669 0.27 0.500 0.33 3 Click to see details
HNSC 0.066 0.34 0.099 0.27 42 Click to see details
BRCA 0.04 0.36 0.022 0.42 84 Click to see details
KIRC -0.044 0.36 -0.036 0.39 68 Click to see details
LIHC -0.029 0.42 -0.006 0.48 49 Click to see details
COAD -0.081 0.42 0.000 0.5 8 Click to see details
PRAD 0.025 0.43 0.034 0.41 50 Click to see details
CESC -0.136 0.46 0.500 0.33 3 Click to see details
KIRP 0.014 0.47 0.021 0.45 32 Click to see details
LUAD 0.02 0.48 0.175 0.29 12 Click to see details
THCA 0.008 0.48 -0.035 0.4 59 Click to see details
THCA 0.008 0.48 -0.035 0.4 59 Click to see details
THCA 0.008 0.48 -0.035 0.4 59 Click to see details
753 hsa-miR-98-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT001124 E2F1 E2F transcription factor 1 2 1
MIRT001126 E2F2 E2F transcription factor 2 4 1
MIRT002999 HMGA2 high mobility group AT-hook 2 7 8
MIRT003438 MYC MYC proto-oncogene, bHLH transcription factor 4 5
MIRT003574 CASP3 caspase 3 3 2
MIRT004305 NCOA3 nuclear receptor coactivator 3 5 4
MIRT004411 TUSC2 tumor suppressor candidate 2 4 3
MIRT004941 ZFP36L1 ZFP36 ring finger protein like 1 2 1
MIRT004942 ZMPSTE24 zinc metallopeptidase STE24 2 1
MIRT004943 THBS1 thrombospondin 1 5 5
MIRT004944 SERP1 stress associated endoplasmic reticulum protein 1 2 1
MIRT004945 SLC20A1 solute carrier family 20 member 1 5 6
MIRT004946 MEIS1 Meis homeobox 1 2 1
MIRT004947 CNOT4 CCR4-NOT transcription complex subunit 4 2 1
MIRT004948 HNRPDL heterogeneous nuclear ribonucleoprotein D like 2 1
MIRT004949 AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 2 1
MIRT004950 CBX5 chromobox 5 4 3
MIRT004951 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 1
MIRT004953 ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 2 1
MIRT005326 SOCS4 suppressor of cytokine signaling 4 4 1
MIRT005676 KLF13 Kruppel like factor 13 1 1
MIRT005677 CCL5 C-C motif chemokine ligand 5 3 2
MIRT005721 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3 2
MIRT006397 IL13 interleukin 13 2 1
MIRT006408 MPL MPL proto-oncogene, thrombopoietin receptor 1 1
MIRT007106 CCNJ cyclin J 2 2
MIRT027399 SNRPC small nuclear ribonucleoprotein polypeptide C 1 1
MIRT027400 MRPL12 mitochondrial ribosomal protein L12 3 3
MIRT027401 MIR671 microRNA 671 1 1
MIRT027402 COLGALT1 collagen beta(1-O)galactosyltransferase 1 1 1
MIRT027403 ZFAND3 zinc finger AN1-type containing 3 1 1
MIRT027404 GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 1 1
MIRT027405 INHBE inhibin beta E subunit 1 1
MIRT027406 SNX24 sorting nexin 24 1 1
MIRT027407 SUV39H1 suppressor of variegation 3-9 homolog 1 1 1
MIRT027408 HIST2H4A histone cluster 2 H4 family member a 1 1
MIRT027409 KCNJ15 potassium voltage-gated channel subfamily J member 15 1 1
MIRT027410 WBP11 WW domain binding protein 11 1 1
MIRT027411 BFAR bifunctional apoptosis regulator 1 1
MIRT027412 ARRB1 arrestin beta 1 1 1
MIRT027413 ABCF1 ATP binding cassette subfamily F member 1 1 1
MIRT027414 VPS54 VPS54, GARP complex subunit 1 1
MIRT027415 GATA6 GATA binding protein 6 1 1
MIRT027416 USP10 ubiquitin specific peptidase 10 1 1
MIRT027417 TIMM17B translocase of inner mitochondrial membrane 17B 1 1
MIRT027418 FADS3 fatty acid desaturase 3 1 1
MIRT027419 RPS6KB1 ribosomal protein S6 kinase B1 1 1
MIRT027420 GMPR2 guanosine monophosphate reductase 2 1 1
MIRT027421 CDC25A cell division cycle 25A 1 1
MIRT027422 MED8 mediator complex subunit 8 1 1
MIRT027423 IL6R interleukin 6 receptor 1 1
MIRT027424 COIL coilin 3 7
MIRT027425 ARHGAP28 Rho GTPase activating protein 28 1 1
MIRT027426 SEC24B SEC24 homolog B, COPII coat complex component 1 1
MIRT027427 CHRNA9 cholinergic receptor nicotinic alpha 9 subunit 1 1
MIRT027428 ARCN1 archain 1 1 1
MIRT027429 KPNA6 karyopherin subunit alpha 6 1 1
MIRT027430 A2M alpha-2-macroglobulin 1 1
MIRT027431 TPST2 tyrosylprotein sulfotransferase 2 1 1
MIRT027432 ZNF573 zinc finger protein 573 1 1
MIRT027433 GRPEL1 GrpE like 1, mitochondrial 1 1
MIRT027434 TMEM45A transmembrane protein 45A 1 1
MIRT027435 TEAD4 TEA domain transcription factor 4 1 1
MIRT027436 SUPV3L1 Suv3 like RNA helicase 1 1
MIRT027437 BIRC3 baculoviral IAP repeat containing 3 1 1
MIRT027438 MYBBP1A MYB binding protein 1a 1 1
MIRT027439 CA9 carbonic anhydrase 9 1 1
MIRT027440 GABRE gamma-aminobutyric acid type A receptor epsilon subunit 1 1
MIRT027441 ECM2 extracellular matrix protein 2 1 1
MIRT027442 CALCB calcitonin related polypeptide beta 1 1
MIRT027443 ASMTL acetylserotonin O-methyltransferase like 1 1
MIRT027444 TNFRSF9 TNF receptor superfamily member 9 1 1
MIRT027445 SNORA25 small nucleolar RNA, H/ACA box 25 1 1
MIRT027446 USP3 ubiquitin specific peptidase 3 1 1
MIRT027447 FOXO1 forkhead box O1 1 1
MIRT027448 SORD sorbitol dehydrogenase 1 1
MIRT027449 IL6 interleukin 6 4 3
MIRT027450 PNRC1 proline rich nuclear receptor coactivator 1 1 1
MIRT027451 HIST1H2AC histone cluster 1 H2A family member c 1 1
MIRT027452 PPAN peter pan homolog (Drosophila) 1 1
MIRT027453 PUS1 pseudouridylate synthase 1 1 1
MIRT027454 CYB5R3 cytochrome b5 reductase 3 1 1
MIRT027455 HIST1H2BE histone cluster 1 H2B family member e 1 1
MIRT027456 TRAF1 TNF receptor associated factor 1 1 1
MIRT027457 SOLH calpain 15 1 1
MIRT027458 TMEM164 transmembrane protein 164 1 1
MIRT027459 ST5 suppression of tumorigenicity 5 1 1
MIRT027460 GAPVD1 GTPase activating protein and VPS9 domains 1 1 1
MIRT027461 AVEN apoptosis and caspase activation inhibitor 1 1
MIRT027462 CPOX coproporphyrinogen oxidase 1 1
MIRT027463 MKNK2 MAP kinase interacting serine/threonine kinase 2 1 1
MIRT027464 LPCAT3 lysophosphatidylcholine acyltransferase 3 1 1
MIRT027465 SNX5 sorting nexin 5 1 1
MIRT027466 HMMR hyaluronan mediated motility receptor 1 1
MIRT027467 RND3 Rho family GTPase 3 1 1
MIRT027468 RASAL2 RAS protein activator like 2 1 1
MIRT027469 C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 4 1
MIRT027470 SERTAD2 SERTA domain containing 2 1 1
MIRT027471 PRDM4 PR/SET domain 4 1 1
MIRT027472 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 1
MIRT027473 NIPSNAP1 nipsnap homolog 1 1 1
MIRT027474 MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria 1 1
MIRT027475 KIAA0922 transmembrane 131 like 1 1
MIRT027476 ATG9A autophagy related 9A 3 3
MIRT027477 TMEM8A transmembrane protein 8A 1 1
MIRT027478 ARSJ arylsulfatase family member J 1 1
MIRT027479 RNF13 ring finger protein 13 1 1
MIRT027480 XPO4 exportin 4 1 1
MIRT027481 ATP7B ATPase copper transporting beta 1 1
MIRT027482 SMAD7 SMAD family member 7 1 1
MIRT027483 HIST2H2BF histone cluster 2 H2B family member f 1 1
MIRT027484 ALG3 ALG3, alpha-1,3- mannosyltransferase 1 1
MIRT027485 GATAD2A GATA zinc finger domain containing 2A 1 1
MIRT027486 CANT1 calcium activated nucleotidase 1 1 1
MIRT027487 PDHB pyruvate dehydrogenase E1 beta subunit 1 1
MIRT027488 TTI1 TELO2 interacting protein 1 1 1
MIRT027489 CAP1 cyclase associated actin cytoskeleton regulatory protein 1 1 1
MIRT027490 MLXIP MLX interacting protein 1 1
MIRT027491 MAGEA6 MAGE family member A6 1 1
MIRT027492 TAF5L TATA-box binding protein associated factor 5 like 1 1
MIRT027493 VAV3 vav guanine nucleotide exchange factor 3 1 1
MIRT027494 STEAP3 STEAP3 metalloreductase 1 1
MIRT027495 MTF2 metal response element binding transcription factor 2 1 1
MIRT027496 TLDC1 TBC/LysM-associated domain containing 1 1 1
MIRT027497 GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 1 1
MIRT027498 ADCY9 adenylate cyclase 9 1 1
MIRT027499 TRIB1 tribbles pseudokinase 1 1 1
MIRT027500 ATP13A3 ATPase 13A3 1 1
MIRT027501 YIPF1 Yip1 domain family member 1 1 1
MIRT027502 ZNF473 zinc finger protein 473 1 1
MIRT027503 MED6 mediator complex subunit 6 1 1
MIRT027504 GNG5 G protein subunit gamma 5 3 3
MIRT027505 ZNF202 zinc finger protein 202 1 1
MIRT027506 DUSP9 dual specificity phosphatase 9 1 1
MIRT027507 CDKN1A cyclin dependent kinase inhibitor 1A 3 3
MIRT027508 VPS33A VPS33A, CORVET/HOPS core subunit 1 1
MIRT027509 TAF5 TATA-box binding protein associated factor 5 1 1
MIRT027510 PXDN peroxidasin 1 1
MIRT027511 RGS16 regulator of G protein signaling 16 1 1
MIRT027512 ABCC5 ATP binding cassette subfamily C member 5 1 1
MIRT027513 TARBP2 TARBP2, RISC loading complex RNA binding subunit 1 1
MIRT027514 CPA4 carboxypeptidase A4 3 3
MIRT027515 FNDC3A fibronectin type III domain containing 3A 3 3
MIRT027516 TNFSF9 TNF superfamily member 9 3 3
MIRT027517 OSMR oncostatin M receptor 1 1
MIRT027518 BMP2K BMP2 inducible kinase 1 1
MIRT027519 IFI16 interferon gamma inducible protein 16 1 1
MIRT027520 REL REL proto-oncogene, NF-kB subunit 1 1
MIRT027521 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 1 1
MIRT027522 EGLN3 egl-9 family hypoxia inducible factor 3 1 1
MIRT027523 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 1 1
MIRT027524 IL32 interleukin 32 1 1
MIRT027525 HIST1H2BJ histone cluster 1 H2B family member j 1 1
MIRT027526 COQ10B coenzyme Q10B 1 1
MIRT027527 HIST1H4H histone cluster 1 H4 family member h 1 1
MIRT027528 TIMM13 translocase of inner mitochondrial membrane 13 1 1
MIRT027529 HIST1H2BG histone cluster 1 H2B family member g 1 1
MIRT027530 PALMD palmdelphin 1 1
MIRT027531 SCHIP1 schwannomin interacting protein 1 1 1
MIRT027532 NUAK2 NUAK family kinase 2 1 1
MIRT027533 SEC31A SEC31 homolog A, COPII coat complex component 1 1
MIRT027534 TNFRSF21 TNF receptor superfamily member 21 1 1
MIRT027535 ZNF74 zinc finger protein 74 1 1
MIRT027536 HIST2H2BC histone cluster 2 H2B family member c (pseudogene) 1 1
MIRT027537 STC2 stanniocalcin 2 1 1
MIRT027538 NOLC1 nucleolar and coiled-body phosphoprotein 1 1 1
MIRT027539 NARF nuclear prelamin A recognition factor 1 1
MIRT027540 PALM2-AKAP2 PALM2-AKAP2 readthrough 1 1
MIRT027541 HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 1 1
MIRT027542 EMR2 adhesion G protein-coupled receptor E2 1 1
MIRT027543 B4GALT3 beta-1,4-galactosyltransferase 3 1 1
MIRT027544 HIST1H2BH histone cluster 1 H2B family member h 1 1
MIRT027545 JAG1 jagged 1 1 1
MIRT027546 MFSD5 major facilitator superfamily domain containing 5 1 1
MIRT027547 PDCD11 programmed cell death 11 1 1
MIRT027548 RTCA RNA 3'-terminal phosphate cyclase 1 1
MIRT027549 AKAP2 A-kinase anchoring protein 2 1 1
MIRT027550 HIST1H2BL histone cluster 1 H2B family member l 1 1
MIRT027551 NPR3 natriuretic peptide receptor 3 1 1
MIRT027552 SPRY1 sprouty RTK signaling antagonist 1 1 1
MIRT027553 GNPTAB N-acetylglucosamine-1-phosphate transferase alpha and beta subunits 1 1
MIRT027554 PROSER1 proline and serine rich 1 1 1
MIRT027555 LAMC1 laminin subunit gamma 1 1 1
MIRT027556 MBNL2 muscleblind like splicing regulator 2 1 1
MIRT027557 POM121 POM121 transmembrane nucleoporin 1 1
MIRT027558 MGEA5 meningioma expressed antigen 5 (hyaluronidase) 1 1
MIRT027559 CDK17 cyclin dependent kinase 17 1 1
MIRT027560 RASSF9 Ras association domain family member 9 1 1
MIRT027561 PARP12 poly(ADP-ribose) polymerase family member 12 1 1
MIRT027562 AHR aryl hydrocarbon receptor 3 3
MIRT027563 CHML CHM like, Rab escort protein 2 1 1
MIRT027564 MYLK3 myosin light chain kinase 3 1 1
MIRT027565 ZNF281 zinc finger protein 281 1 1
MIRT027566 EIF4E2 eukaryotic translation initiation factor 4E family member 2 1 1
MIRT027567 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 1 1
MIRT027568 LRFN4 leucine rich repeat and fibronectin type III domain containing 4 1 1
MIRT027569 RHBDF2 rhomboid 5 homolog 2 1 1
MIRT027570 EIF3J eukaryotic translation initiation factor 3 subunit J 1 1
MIRT027571 TEAD1 TEA domain transcription factor 1 1 1
MIRT027572 ROR1 receptor tyrosine kinase like orphan receptor 1 1 1
MIRT027573 C10orf88 chromosome 10 open reading frame 88 1 1
MIRT027574 GPR56 adhesion G protein-coupled receptor G1 1 1
MIRT027575 BIN3 bridging integrator 3 1 1
MIRT027576 DOCK4 dedicator of cytokinesis 4 1 1
MIRT027577 OSBPL10 oxysterol binding protein like 10 1 1
MIRT027578 BAZ1A bromodomain adjacent to zinc finger domain 1A 1 1
MIRT027579 RBPMS RNA binding protein with multiple splicing 1 1
MIRT027580 TMEM2 transmembrane protein 2 1 1
MIRT027581 PLAG1 PLAG1 zinc finger 1 1
MIRT027582 DOLK dolichol kinase 1 1
MIRT027583 PHKA1 phosphorylase kinase regulatory subunit alpha 1 1 1
MIRT027584 MAPRE1 microtubule associated protein RP/EB family member 1 1 1
MIRT027585 RPAP1 RNA polymerase II associated protein 1 1 1
MIRT027586 CDC23 cell division cycle 23 1 1
MIRT027587 MIOS meiosis regulator for oocyte development 1 1
MIRT027588 RRP1B ribosomal RNA processing 1B 1 1
MIRT027589 POM121C POM121 transmembrane nucleoporin C 1 1
MIRT027590 UBE2D3 ubiquitin conjugating enzyme E2 D3 1 1
MIRT027591 BTN2A1 butyrophilin subfamily 2 member A1 1 1
MIRT027592 CEBPD CCAAT/enhancer binding protein delta 1 1
MIRT027593 ASCC3 activating signal cointegrator 1 complex subunit 3 1 1
MIRT027594 CLP1 cleavage and polyadenylation factor I subunit 1 1 1
MIRT027595 GNG5P2 G protein subunit gamma 5 pseudogene 2 1 1
MIRT027596 TSC22D2 TSC22 domain family member 2 3 5
MIRT027597 WDR73 WD repeat domain 73 1 1
MIRT027598 FAS Fas cell surface death receptor 1 1
MIRT027599 TXLNG taxilin gamma 3 3
MIRT027600 SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 1 1
MIRT027601 PGRMC1 progesterone receptor membrane component 1 6 4
MIRT027602 PPARGC1A PPARG coactivator 1 alpha 1 1
MIRT027603 TTLL4 tubulin tyrosine ligase like 4 1 1
MIRT027604 TMEM38B transmembrane protein 38B 1 1
MIRT027605 SPARCL1 SPARC like 1 1 1
MIRT027606 DDX10 DEAD-box helicase 10 1 1
MIRT027607 IER3 immediate early response 3 1 1
MIRT027608 TMEM147 transmembrane protein 147 1 1
MIRT027609 ZDHHC3 zinc finger DHHC-type containing 3 1 1
MIRT027610 KLF10 Kruppel like factor 10 1 1
MIRT027611 NLE1 notchless homolog 1 1 1
MIRT027612 MITF melanogenesis associated transcription factor 1 1
MIRT027613 RAPGEF4 Rap guanine nucleotide exchange factor 4 1 1
MIRT027614 SGMS1 sphingomyelin synthase 1 1 1
MIRT027615 ICAM1 intercellular adhesion molecule 1 1 1
MIRT027616 CHPF2 chondroitin polymerizing factor 2 1 1
MIRT027617 WDR74 WD repeat domain 74 1 1
MIRT027618 OXA1L OXA1L, mitochondrial inner membrane protein 1 1
MIRT027619 RABGGTB Rab geranylgeranyltransferase beta subunit 1 1
MIRT027620 TES testin LIM domain protein 1 1
MIRT027621 DUSP10 dual specificity phosphatase 10 1 1
MIRT027622 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 1 1
MIRT027623 MOB3B MOB kinase activator 3B 1 1
MIRT027624 HIST1H2BF histone cluster 1 H2B family member f 1 1
MIRT027625 SYNGR2 synaptogyrin 2 1 1
MIRT027626 GPR37 G protein-coupled receptor 37 1 1
MIRT027627 ZFX zinc finger protein, X-linked 1 1
MIRT027628 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 1 1
MIRT027629 HIST1H2BI histone cluster 1 H2B family member i 1 1
MIRT027630 TEX10 testis expressed 10 1 1
MIRT027631 TBC1D4 TBC1 domain family member 4 1 1
MIRT027632 NAV2 neuron navigator 2 1 1
MIRT027633 TRAF3IP2 TRAF3 interacting protein 2 1 1
MIRT027634 PDSS1 decaprenyl diphosphate synthase subunit 1 1 1
MIRT027635 ACTL8 actin like 8 1 1
MIRT027636 WDR33 WD repeat domain 33 1 1
MIRT027637 PPT2 palmitoyl-protein thioesterase 2 1 1
MIRT027638 FZD10 frizzled class receptor 10 1 1
MIRT027639 CLINT1 clathrin interactor 1 1 1
MIRT027640 FAM134C reticulophagy regulator family member 3 1 1
MIRT027641 C8orf4 chromosome 8 open reading frame 4 1 1
MIRT027642 HIST1H2AG histone cluster 1 H2A family member g 1 1
MIRT027643 PPAP2B phospholipid phosphatase 3 1 1
MIRT027644 NFKB2 nuclear factor kappa B subunit 2 1 1
MIRT027645 LIFR LIF receptor alpha 1 1
MIRT027646 DOCK5 dedicator of cytokinesis 5 1 1
MIRT027647 HIST1H3D histone cluster 1 H3 family member d 1 1
MIRT027648 MRPS2 mitochondrial ribosomal protein S2 1 1
MIRT027649 PSMD11 proteasome 26S subunit, non-ATPase 11 1 1
MIRT027650 KLF3 Kruppel like factor 3 1 1
MIRT027651 CD46 CD46 molecule 1 1
MIRT027652 CNIH cornichon family AMPA receptor auxiliary protein 1 1 1
MIRT027653 ARID1A AT-rich interaction domain 1A 1 1
MIRT027654 STK17B serine/threonine kinase 17b 1 1
MIRT027655 MED24 mediator complex subunit 24 1 1
MIRT027656 COG5 component of oligomeric golgi complex 5 1 1
MIRT027657 RBM19 RNA binding motif protein 19 1 1
MIRT027658 HSPB7 heat shock protein family B (small) member 7 1 1
MIRT027659 IFNAR1 interferon alpha and beta receptor subunit 1 1 1
MIRT027660 RAB30 RAB30, member RAS oncogene family 1 1
MIRT027661 THOC5 THO complex 5 1 1
MIRT027662 SLC19A2 solute carrier family 19 member 2 1 1
MIRT027663 PRRC2C proline rich coiled-coil 2C 1 1
MIRT027664 SLC25A13 solute carrier family 25 member 13 1 1
MIRT027665 HK2 hexokinase 2 4 2
MIRT027666 AGPS alkylglycerone phosphate synthase 1 1
MIRT027667 SACS sacsin molecular chaperone 1 1
MIRT027668 SLC16A3 solute carrier family 16 member 3 1 1
MIRT027669 PIGC phosphatidylinositol glycan anchor biosynthesis class C 1 1
MIRT027670 SLC2A3 solute carrier family 2 member 3 1 1
MIRT027671 VGLL3 vestigial like family member 3 1 1
MIRT027672 PLK2 polo like kinase 2 1 1
MIRT027673 HDHD1 pseudouridine 5'-phosphatase 1 1
MIRT027674 IQCB1 IQ motif containing B1 1 1
MIRT027675 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 3 3
MIRT027676 ALKBH1 alkB homolog 1, histone H2A dioxygenase 1 1
MIRT027677 SLC35F2 solute carrier family 35 member F2 1 1
MIRT027678 SLC5A6 solute carrier family 5 member 6 3 5
MIRT027679 FAM60A SIN3-HDAC complex associated factor 1 1
MIRT027680 FNDC3B fibronectin type III domain containing 3B 1 1
MIRT027681 CRTAP cartilage associated protein 1 1
MIRT027682 E2F6 E2F transcription factor 6 3 3
MIRT027683 MAGEA2B MAGE family member A2B 1 1
MIRT027684 ESRP2 epithelial splicing regulatory protein 2 1 1
MIRT027685 ADA adenosine deaminase 1 1
MIRT027686 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 1 1
MIRT027687 CDC34 cell division cycle 34 1 1
MIRT027688 GDAP2 ganglioside induced differentiation associated protein 2 1 1
MIRT027689 SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 1 1
MIRT027690 ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 1 1
MIRT027691 RPS6KB2 ribosomal protein S6 kinase B2 1 1
MIRT027692 SLC35D2 solute carrier family 35 member D2 1 1
MIRT027693 DIDO1 death inducer-obliterator 1 1 1
MIRT027694 HIST1H2BO histone cluster 1 H2B family member o 1 1
MIRT027695 HIST1H2BC histone cluster 1 H2B family member c 1 1
MIRT027696 LTBR lymphotoxin beta receptor 1 1
MIRT027697 SLC25A32 solute carrier family 25 member 32 1 1
MIRT027698 PTTG1IP PTTG1 interacting protein 1 1
MIRT027699 MTPAP mitochondrial poly(A) polymerase 1 1
MIRT027700 NRBF2 nuclear receptor binding factor 2 1 1
MIRT027701 FAM69A family with sequence similarity 69 member A 1 1
MIRT027702 LMO7 LIM domain 7 1 1
MIRT027703 PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 1 1
MIRT027704 NFIL3 nuclear factor, interleukin 3 regulated 1 1
MIRT027705 SEMA3C semaphorin 3C 1 1
MIRT027706 SLC17A5 solute carrier family 17 member 5 1 1
MIRT027707 PRKRIR THAP domain containing 12 1 1
MIRT027708 MRTO4 MRT4 homolog, ribosome maturation factor 1 1
MIRT027709 CDKN1B cyclin dependent kinase inhibitor 1B 1 1
MIRT027710 NNMT nicotinamide N-methyltransferase 1 1
MIRT027711 HIST2H4B histone cluster 2 H4 family member b 1 1
MIRT027712 MAGEB2 MAGE family member B2 1 1
MIRT027713 RNF111 ring finger protein 111 1 1
MIRT027714 CDKN2B cyclin dependent kinase inhibitor 2B 1 1
MIRT027715 AIM1 crystallin beta-gamma domain containing 1 1 1
MIRT027716 KCTD5 potassium channel tetramerization domain containing 5 1 1
MIRT027717 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 1 1
MIRT027718 POLR1D RNA polymerase I subunit D 1 1
MIRT027719 CHD7 chromodomain helicase DNA binding protein 7 1 1
MIRT027720 AKR1C3 aldo-keto reductase family 1 member C3 1 1
MIRT027721 ZKSCAN8 zinc finger with KRAB and SCAN domains 8 1 1
MIRT027722 IFNGR1 interferon gamma receptor 1 1 1
MIRT027723 C10orf2 twinkle mtDNA helicase 1 1
MIRT027724 PLOD2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 1 1
MIRT027725 HEG1 heart development protein with EGF like domains 1 1 1
MIRT027726 CXCL2 C-X-C motif chemokine ligand 2 1 1
MIRT027727 POLR3E RNA polymerase III subunit E 1 1
MIRT027728 NREP neuronal regeneration related protein 1 1
MIRT027729 HIST1H2BD histone cluster 1 H2B family member d 3 5
MIRT027730 TFPI tissue factor pathway inhibitor 1 1
MIRT027731 PLAGL1 PLAG1 like zinc finger 1 1 1
MIRT027732 ZBTB24 zinc finger and BTB domain containing 24 1 1
MIRT027733 VAMP3 vesicle associated membrane protein 3 1 1
MIRT027734 SOAT1 sterol O-acyltransferase 1 1 1
MIRT027735 NUP98 nucleoporin 98 1 1
MIRT027736 RGS19 regulator of G protein signaling 19 1 1
MIRT027737 P2RX5 purinergic receptor P2X 5 1 1
MIRT027738 UTP20 UTP20, small subunit processome component 1 1
MIRT027739 DENND1A DENN domain containing 1A 1 1
MIRT027740 URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 1 1
MIRT027741 DHX57 DExH-box helicase 57 1 1
MIRT027742 SLC19A3 solute carrier family 19 member 3 3 3
MIRT027743 TBC1D30 TBC1 domain family member 30 1 1
MIRT027744 KCTD14 potassium channel tetramerization domain containing 14 1 1
MIRT027745 LRIG1 leucine rich repeats and immunoglobulin like domains 1 1 1
MIRT027746 PABPC4 poly(A) binding protein cytoplasmic 4 1 1
MIRT027747 NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 1 1
MIRT027748 FLAD1 flavin adenine dinucleotide synthetase 1 1 1
MIRT027749 OLR1 oxidized low density lipoprotein receptor 1 1 1
MIRT027750 SMCR7L mitochondrial elongation factor 1 2 5
MIRT027751 TRAM2 translocation associated membrane protein 2 1 1
MIRT027752 DBF4 DBF4 zinc finger 1 1
MIRT027753 ITGA5 integrin subunit alpha 5 1 1
MIRT027754 ZFHX3 zinc finger homeobox 3 1 1
MIRT027755 TMEM41B transmembrane protein 41B 1 1
MIRT027756 FAM46C family with sequence similarity 46 member C 1 1
MIRT027757 PHACTR4 phosphatase and actin regulator 4 3 3
MIRT027758 ALG8 ALG8, alpha-1,3-glucosyltransferase 1 1
MIRT027759 GLMN glomulin, FKBP associated protein 1 1
MIRT027760 ERGIC2 ERGIC and golgi 2 1 1
MIRT027761 C6orf211 acidic residue methyltransferase 1 1 1
MIRT027762 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 1 1
MIRT027763 PSME4 proteasome activator subunit 4 1 1
MIRT027764 DPAGT1 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 1 1
MIRT027765 CTSC cathepsin C 1 1
MIRT027766 DTX4 deltex E3 ubiquitin ligase 4 1 1
MIRT027767 ATP6V1G1 ATPase H+ transporting V1 subunit G1 3 7
MIRT027768 S100A8 S100 calcium binding protein A8 1 1
MIRT027769 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 1 1
MIRT027770 TNFSF10 TNF superfamily member 10 1 1
MIRT027771 CHD4 chromodomain helicase DNA binding protein 4 1 1
MIRT027772 NME6 NME/NM23 nucleoside diphosphate kinase 6 1 1
MIRT027773 TFAP2A transcription factor AP-2 alpha 1 1
MIRT027774 BTBD3 BTB domain containing 3 1 1
MIRT027775 PCTP phosphatidylcholine transfer protein 1 1
MIRT027776 ZNF200 zinc finger protein 200 3 5
MIRT027777 C11orf57 chromosome 11 open reading frame 57 3 5
MIRT027778 FZD3 frizzled class receptor 3 1 1
MIRT027779 CLUH clustered mitochondria homolog 1 1
MIRT027780 CCNF cyclin F 1 1
MIRT027781 SEMA3G semaphorin 3G 1 1
MIRT027782 SLC2A14 solute carrier family 2 member 14 1 1
MIRT027783 CXCR7 atypical chemokine receptor 3 1 1
MIRT027784 PICALM phosphatidylinositol binding clathrin assembly protein 1 1
MIRT027785 TNS1 tensin 1 1 1
MIRT027786 SOX4 SRY-box 4 1 1
MIRT027787 CDK7 cyclin dependent kinase 7 1 1
MIRT027788 SCG2 secretogranin II 1 1
MIRT027789 MCAT malonyl-CoA-acyl carrier protein transacylase 1 1
MIRT027790 GNA12 G protein subunit alpha 12 1 1
MIRT027791 RB1CC1 RB1 inducible coiled-coil 1 1 1
MIRT027792 NELFCD negative elongation factor complex member C/D 1 1
MIRT027793 USP36 ubiquitin specific peptidase 36 1 1
MIRT027794 DIEXF digestive organ expansion factor homolog (zebrafish) 1 1
MIRT027795 MAST4 microtubule associated serine/threonine kinase family member 4 1 1
MIRT027796 CRKL CRK like proto-oncogene, adaptor protein 1 1
MIRT027797 HIST1H1C histone cluster 1 H1 family member c 1 1
MIRT027798 COA1 cytochrome c oxidase assembly factor 1 homolog 1 1
MIRT027799 CHD1 chromodomain helicase DNA binding protein 1 1 1
MIRT027800 CHST11 carbohydrate sulfotransferase 11 1 1
MIRT027801 IP6K2 inositol hexakisphosphate kinase 2 1 1
MIRT027802 CFB complement factor B 1 1
MIRT027803 NR2F6 nuclear receptor subfamily 2 group F member 6 1 1
MIRT027804 WNT10B Wnt family member 10B 1 1
MIRT027805 VANGL1 VANGL planar cell polarity protein 1 1 1
MIRT027806 C19orf53 chromosome 19 open reading frame 53 3 3
MIRT027807 GPN1 GPN-loop GTPase 1 1 1
MIRT027808 AK2 adenylate kinase 2 1 1
MIRT027809 FAM57A family with sequence similarity 57 member A 1 1
MIRT027810 JMJD4 jumonji domain containing 4 1 1
MIRT027811 HIST1H2BK histone cluster 1 H2B family member k 3 3
MIRT027812 ZBED4 zinc finger BED-type containing 4 1 1
MIRT027813 ZNF267 zinc finger protein 267 1 1
MIRT027814 C3 complement C3 1 1
MIRT027815 TET3 tet methylcytosine dioxygenase 3 1 1
MIRT027816 BCL9 B-cell CLL/lymphoma 9 1 1
MIRT027817 ZFAND5 zinc finger AN1-type containing 5 1 1
MIRT027818 ABCC1 ATP binding cassette subfamily C member 1 1 1
MIRT027819 CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 3 3
MIRT027820 HBEGF heparin binding EGF like growth factor 1 1
MIRT027821 MED13L mediator complex subunit 13 like 1 1
MIRT027822 MTUS1 microtubule associated scaffold protein 1 3 7
MIRT027823 SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1 1
MIRT027824 FKBP3 FK506 binding protein 3 1 1
MIRT027825 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 1 1
MIRT027826 PPAT phosphoribosyl pyrophosphate amidotransferase 1 1
MIRT027827 PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 1 1
MIRT027828 TCERG1 transcription elongation regulator 1 1 1
MIRT027829 CCNA2 cyclin A2 1 1
MIRT027830 SIGMAR1 sigma non-opioid intracellular receptor 1 1 1
MIRT027831 RHOBTB3 Rho related BTB domain containing 3 1 1
MIRT027832 SLC7A6 solute carrier family 7 member 6 1 1
MIRT027833 AKR1B10 aldo-keto reductase family 1 member B10 1 1
MIRT027834 LGR4 leucine rich repeat containing G protein-coupled receptor 4 1 1
MIRT027835 C5orf30 chromosome 5 open reading frame 30 1 1
MIRT027836 PLAGL2 PLAG1 like zinc finger 2 3 3
MIRT027837 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 1 1
MIRT027838 ZBTB39 zinc finger and BTB domain containing 39 1 1
MIRT027839 RIPK2 receptor interacting serine/threonine kinase 2 1 1
MIRT027840 WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 1 1
MIRT027841 PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 1 1
MIRT027842 LEPROTL1 leptin receptor overlapping transcript like 1 1 1
MIRT027843 ANKRD11 ankyrin repeat domain 11 1 1
MIRT027844 UST uronyl 2-sulfotransferase 1 1
MIRT027845 CHST3 carbohydrate sulfotransferase 3 1 1
MIRT027846 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 1 1
MIRT027847 ZBTB10 zinc finger and BTB domain containing 10 1 1
MIRT027848 MAGEA2 MAGE family member A2 1 1
MIRT027849 NEK3 NIMA related kinase 3 1 1
MIRT027850 ERO1L endoplasmic reticulum oxidoreductase 1 alpha 1 1
MIRT027851 POU2F1 POU class 2 homeobox 1 1 1
MIRT027852 HMGA1 high mobility group AT-hook 1 3 5
MIRT027853 IGF2BP2 insulin like growth factor 2 mRNA binding protein 2 1 1
MIRT027854 RNF44 ring finger protein 44 3 5
MIRT027855 IMPDH1 inosine monophosphate dehydrogenase 1 1 1
MIRT027856 SNAP23 synaptosome associated protein 23 1 1
MIRT027857 ARID3A AT-rich interaction domain 3A 3 3
MIRT027858 DICER1 dicer 1, ribonuclease III 1 1
MIRT027859 ABT1 activator of basal transcription 1 3 9
MIRT027860 XK X-linked Kx blood group 1 1
MIRT027861 FGD6 FYVE, RhoGEF and PH domain containing 6 1 1
MIRT027862 NRAS NRAS proto-oncogene, GTPase 1 1
MIRT027863 IRS2 insulin receptor substrate 2 1 1
MIRT027864 FRMD4B FERM domain containing 4B 1 1
MIRT027865 TGFBR1 transforming growth factor beta receptor 1 1 1
MIRT027866 PPP4C protein phosphatase 4 catalytic subunit 1 1
MIRT027867 MRS2 MRS2, magnesium transporter 1 1
MIRT027868 YOD1 YOD1 deubiquitinase 3 7
MIRT048710 ITGB3 integrin subunit beta 3 1 1
MIRT048711 CDC42BPA CDC42 binding protein kinase alpha 1 1
MIRT048712 E2F4 E2F transcription factor 4 1 1
MIRT048713 NDUFAF3 NADH:ubiquinone oxidoreductase complex assembly factor 3 1 1
MIRT052994 CYP19A1 cytochrome P450 family 19 subfamily A member 1 3 2
MIRT063197 ADIPOR2 adiponectin receptor 2 2 2
MIRT065689 ESPL1 extra spindle pole bodies like 1, separase 2 4
MIRT067401 TMTC3 transmembrane and tetratricopeptide repeat containing 3 2 2
MIRT068156 TXLNA taxilin alpha 2 2
MIRT068530 NHLRC3 NHL repeat containing 3 2 6
MIRT073007 ARID3B AT-rich interaction domain 3B 2 6
MIRT073671 IGF1R insulin like growth factor 1 receptor 6 9
MIRT076225 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 6
MIRT077617 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 6 2
MIRT080400 ONECUT2 one cut homeobox 2 2 2
MIRT083302 ZCCHC3 zinc finger CCHC-type containing 3 2 2
MIRT084978 BACH1 BTB domain and CNC homolog 1 2 2
MIRT094162 PCGF3 polycomb group ring finger 3 2 6
MIRT094463 SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 2 4
MIRT095768 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT112244 MDM4 MDM4, p53 regulator 2 4
MIRT118588 STK4 serine/threonine kinase 4 2 2
MIRT120923 PDE12 phosphodiesterase 12 2 8
MIRT123320 CALU calumenin 2 2
MIRT123978 POLR3D RNA polymerase III subunit D 2 2
MIRT134736 CCND2 cyclin D2 1 1
MIRT180605 CRY2 cryptochrome circadian clock 2 2 2
MIRT187719 SUOX sulfite oxidase 2 2
MIRT191406 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT193103 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT215722 C5ORF51 chromosome 5 open reading frame 51 2 10
MIRT225973 E2F5 E2F transcription factor 5 3 1
MIRT240332 UBXN2B UBX domain protein 2B 2 2
MIRT243475 TRIM71 tripartite motif containing 71 2 2
MIRT244073 EDN1 endothelin 1 3 3
MIRT252332 SALL3 spalt like transcription factor 3 2 2
MIRT255316 CDV3 CDV3 homolog 2 2
MIRT260709 CLDN12 claudin 12 2 6
MIRT266215 PEX11B peroxisomal biogenesis factor 11 beta 2 2
MIRT266628 CHTOP chromatin target of PRMT1 2 2
MIRT268841 C1ORF21 chromosome 1 open reading frame 21 2 2
MIRT284529 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT294448 ZNF264 zinc finger protein 264 2 2
MIRT297015 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT300039 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT300895 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT303322 MXD1 MAX dimerization protein 1 2 2
MIRT309848 NAT8L N-acetyltransferase 8 like 2 2
MIRT322430 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT324733 ACER2 alkaline ceramidase 2 2 2
MIRT402059 ATP6V1F ATPase H+ transporting V1 subunit F 2 4
MIRT437868 CBL Cbl proto-oncogene 3 1
MIRT442015 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT447130 KIF27 kinesin family member 27 2 2
MIRT448253 ZNF774 zinc finger protein 774 2 2
MIRT449001 ANKRD46 ankyrin repeat domain 46 2 2
MIRT449947 FMNL3 formin like 3 2 2
MIRT451618 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT451687 C1RL complement C1r subcomponent like 2 2
MIRT452086 NUCB2 nucleobindin 2 2 2
MIRT452425 QDPR quinoid dihydropteridine reductase 2 2
MIRT452937 DISC1 disrupted in schizophrenia 1 2 2
MIRT453395 RHD Rh blood group D antigen 2 6
MIRT454274 FXN frataxin 2 2
MIRT454533 RABL2A RAB, member of RAS oncogene family like 2A 2 2
MIRT454848 ACOT9 acyl-CoA thioesterase 9 2 4
MIRT455670 GLO1 glyoxalase I 2 2
MIRT457242 RABL2B RAB, member of RAS oncogene family like 2B 2 2
MIRT457672 ZNF587 zinc finger protein 587 2 2
MIRT457881 THEM6 thioesterase superfamily member 6 2 4
MIRT458273 FUT10 fucosyltransferase 10 2 2
MIRT459731 RRM1 ribonucleotide reductase catalytic subunit M1 2 2
MIRT460448 NOM1 nucleolar protein with MIF4G domain 1 2 4
MIRT460494 FAM105A family with sequence similarity 105 member A 2 6
MIRT460932 NOA1 nitric oxide associated 1 2 4
MIRT461086 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT461163 SLC11A2 solute carrier family 11 member 2 2 4
MIRT461358 COL8A1 collagen type VIII alpha 1 chain 2 2
MIRT462376 YAE1D1 Yae1 domain containing 1 2 2
MIRT462774 ZNF8 zinc finger protein 8 2 2
MIRT463419 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463657 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT464259 VCL vinculin 2 2
MIRT466193 TMED5 transmembrane p24 trafficking protein 5 2 4
MIRT466729 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT469096 RNF144B ring finger protein 144B 2 2
MIRT469719 RAB40C RAB40C, member RAS oncogene family 2 2
MIRT470423 PPP1R15B protein phosphatase 1 regulatory subunit 15B 5 2
MIRT470683 POLR2D RNA polymerase II subunit D 2 4
MIRT470867 PLXND1 plexin D1 2 2
MIRT471274 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT471958 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT472669 NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit 2 2
MIRT473129 MLLT10 MLLT10, histone lysine methyltransferase DOT1L cofactor 2 2
MIRT473822 MAP2K7 mitogen-activated protein kinase kinase 7 2 2
MIRT473934 LYN LYN proto-oncogene, Src family tyrosine kinase 2 2
MIRT474017 LRRC20 leucine rich repeat containing 20 2 2
MIRT474499 KLHDC8B kelch domain containing 8B 2 2
MIRT474761 KIAA0930 KIAA0930 2 2
MIRT474913 KCTD21 potassium channel tetramerization domain containing 21 2 2
MIRT475325 IFNLR1 interferon lambda receptor 1 2 2
MIRT475373 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT475727 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT476542 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT476983 FAM83G family with sequence similarity 83 member G 2 4
MIRT477538 EIF4G2 eukaryotic translation initiation factor 4 gamma 2 2 4
MIRT477683 EFHD2 EF-hand domain family member D2 2 2
MIRT479752 CCND1 cyclin D1 2 2
MIRT481195 ATXN7L3B ataxin 7 like 3B 2 4
MIRT481244 ATXN7L3 ataxin 7 like 3 2 2
MIRT481382 ATG12 autophagy related 12 2 2
MIRT481646 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT481848 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT482214 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT486653 ZNF28 zinc finger protein 28 2 2
MIRT489407 TUBB2A tubulin beta 2A class IIa 2 2
MIRT491859 ZBTB5 zinc finger and BTB domain containing 5 2 8
MIRT492215 SOCS1 suppressor of cytokine signaling 1 2 2
MIRT493328 LIMD2 LIM domain containing 2 2 2
MIRT493895 FAM43A family with sequence similarity 43 member A 2 4
MIRT494257 CEP120 centrosomal protein 120 2 2
MIRT495962 TBC1D19 TBC1 domain family member 19 2 2
MIRT496112 SNX17 sorting nexin 17 2 2
MIRT497869 SLC12A7 solute carrier family 12 member 7 2 2
MIRT498117 PLEKHO1 pleckstrin homology domain containing O1 2 4
MIRT499399 PLCG2 phospholipase C gamma 2 2 4
MIRT499487 GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 2 2
MIRT499647 SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 2 2
MIRT499936 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT500896 STRN striatin 2 4
MIRT501181 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501203 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT501250 SEMA4C semaphorin 4C 2 6
MIRT501324 RNFT1 ring finger protein, transmembrane 1 2 2
MIRT501395 RBFOX2 RNA binding protein, fox-1 homolog 2 2 10
MIRT501438 RAB11FIP4 RAB11 family interacting protein 4 2 2
MIRT501755 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT501938 MBD2 methyl-CpG binding domain protein 2 2 8
MIRT502103 KPNA5 karyopherin subunit alpha 5 2 8
MIRT502129 KMT2D lysine methyltransferase 2D 2 4
MIRT502780 CEP135 centrosomal protein 135 2 2
MIRT502838 CELF1 CUGBP Elav-like family member 1 2 2
MIRT504784 C12orf4 chromosome 12 open reading frame 4 2 2
MIRT505013 ZNF644 zinc finger protein 644 2 2
MIRT505582 SMC1A structural maintenance of chromosomes 1A 2 6
MIRT506365 NUP155 nucleoporin 155 2 6
MIRT506935 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT507250 FIGN fidgetin, microtubule severing factor 2 8
MIRT508395 C1orf210 chromosome 1 open reading frame 210 2 6
MIRT508659 DIABLO diablo IAP-binding mitochondrial protein 2 4
MIRT508926 AK4 adenylate kinase 4 2 4
MIRT510393 ZNF566 zinc finger protein 566 2 6
MIRT511380 IKZF3 IKAROS family zinc finger 3 2 4
MIRT512739 CD59 CD59 molecule (CD59 blood group) 2 4
MIRT515948 C9orf156 tRNA methyltransferase O 2 2
MIRT516077 ZBTB8OS zinc finger and BTB domain containing 8 opposite strand 2 4
MIRT521385 RDX radixin 2 4
MIRT522343 NCKIPSD NCK interacting protein with SH3 domain 2 4
MIRT523626 FZD9 frizzled class receptor 9 2 4
MIRT523727 FBXW2 F-box and WD repeat domain containing 2 2 4
MIRT523989 DVL3 dishevelled segment polarity protein 3 2 2
MIRT524109 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT525721 SOD2 superoxide dismutase 2 2 2
MIRT527757 RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator 2 2
MIRT529721 OPRL1 opioid related nociceptin receptor 1 2 2
MIRT533182 WASL Wiskott-Aldrich syndrome like 2 6
MIRT536372 LEFTY1 left-right determination factor 1 2 2
MIRT543779 RBM12B RNA binding motif protein 12B 2 4
MIRT543862 SLC16A9 solute carrier family 16 member 9 2 2
MIRT545381 PM20D2 peptidase M20 domain containing 2 2 2
MIRT546327 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT547380 MSI2 musashi RNA binding protein 2 2 2
MIRT547578 LRIG3 leucine rich repeats and immunoglobulin like domains 3 2 4
MIRT547833 IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 2 4
MIRT548259 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT548352 EPHA4 EPH receptor A4 2 2
MIRT548533 DUSP1 dual specificity phosphatase 1 2 2
MIRT548563 DNAL1 dynein axonemal light chain 1 2 2
MIRT548788 COLEC12 collectin subfamily member 12 2 2
MIRT548974 CCNT2 cyclin T2 2 2
MIRT549214 BEND4 BEN domain containing 4 2 4
MIRT549757 ZNF611 zinc finger protein 611 2 6
MIRT549793 KIAA0391 KIAA0391 2 2
MIRT549841 ECHDC1 ethylmalonyl-CoA decarboxylase 1 2 2
MIRT550721 PMPCA peptidase, mitochondrial processing alpha subunit 2 4
MIRT550892 ACTA1 actin, alpha 1, skeletal muscle 2 2
MIRT551278 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 6
MIRT551312 GSG2 histone H3 associated protein kinase 2 6
MIRT551926 AKAP8 A-kinase anchoring protein 8 2 4
MIRT551997 RAD18 RAD18, E3 ubiquitin protein ligase 2 2
MIRT552404 ZNF460 zinc finger protein 460 2 4
MIRT553017 USP38 ubiquitin specific peptidase 38 2 2
MIRT555543 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT555719 PDZD8 PDZ domain containing 8 2 2
MIRT557378 HAND1 heart and neural crest derivatives expressed 1 2 2
MIRT557966 FAM222B family with sequence similarity 222 member B 2 2
MIRT559091 C19orf47 chromosome 19 open reading frame 47 2 4
MIRT559491 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 2
MIRT561779 PEG10 paternally expressed 10 2 2
MIRT564397 EMILIN2 elastin microfibril interfacer 2 2 4
MIRT565444 SURF4 surfeit 4 2 2
MIRT566512 PARP16 poly(ADP-ribose) polymerase family member 16 2 2
MIRT568653 ABHD17C abhydrolase domain containing 17C 2 2
MIRT569492 THYN1 thymocyte nuclear protein 1 2 2
MIRT573814 TGOLN2 trans-golgi network protein 2 2 2
MIRT574357 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT574755 GOLGA4 golgin A4 2 2
MIRT574783 FAM104A family with sequence similarity 104 member A 2 2
MIRT576082 Poteg POTE ankyrin domain family, member G 2 2
MIRT576815 Thbs1 thrombospondin 1 2 3
MIRT616364 RWDD1 RWD domain containing 1 2 2
MIRT617845 FMO4 flavin containing monooxygenase 4 2 2
MIRT642388 ZNF556 zinc finger protein 556 2 2
MIRT680513 PRIM2 DNA primase subunit 2 2 2
MIRT680541 ZNF584 zinc finger protein 584 2 2
MIRT680794 ZNF578 zinc finger protein 578 2 2
MIRT680832 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT681135 INTS7 integrator complex subunit 7 2 2
MIRT681265 RFC2 replication factor C subunit 2 2 2
MIRT681317 ZFAND4 zinc finger AN1-type containing 4 2 4
MIRT681353 BRI3BP BRI3 binding protein 2 2
MIRT681500 STAT2 signal transducer and activator of transcription 2 2 2
MIRT681530 ZNF738 zinc finger protein 738 2 2
MIRT681652 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT681732 RAB19 RAB19, member RAS oncogene family 2 4
MIRT681791 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT681863 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT682096 ITGA3 integrin subunit alpha 3 2 4
MIRT682175 SLC38A7 solute carrier family 38 member 7 2 2
MIRT682232 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT682438 MTX3 metaxin 3 2 2
MIRT682634 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT689321 FPR1 formyl peptide receptor 1 2 2
MIRT689724 ATXN2 ataxin 2 2 2
MIRT691030 ZNF799 zinc finger protein 799 2 2
MIRT691929 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT694878 ZNF417 zinc finger protein 417 2 2
MIRT695249 ZNF443 zinc finger protein 443 2 2
MIRT695407 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT700594 PRSS22 protease, serine 22 2 2
MIRT701435 NHLRC2 NHL repeat containing 2 2 2
MIRT702478 KIAA1328 KIAA1328 2 2
MIRT702706 IPO9 importin 9 2 2
MIRT704037 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT704416 CTPS1 CTP synthase 1 2 2
MIRT705744 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT712365 NAP1L1 nucleosome assembly protein 1 like 1 2 2
MIRT713514 PAFAH2 platelet activating factor acetylhydrolase 2 2 2
MIRT731967 SNX6 sorting nexin 6 3 1
MIRT732086 PBX3 PBX homeobox 3 3 1
MIRT732227 IGF1 insulin like growth factor 1 3 1
MIRT733884 HLF HLF, PAR bZIP transcription factor 4 0
MIRT734703 TMPRSS2 transmembrane protease, serine 2 1 0
MIRT735170 TMED10 transmembrane p24 trafficking protein 10 2 0
MIRT735717 BRAF B-Raf proto-oncogene, serine/threonine kinase 1 0
MIRT735862 KRAS KRAS proto-oncogene, GTPase 1 0
MIRT737236 DSCR8 Down syndrome critical region 8 (non-protein coding) 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-98 Lenalidomide approved 216326 Quantitative real-time PCR peripheral blood CD14+ monocytes 25287904 2014 up-regulated
miR-98 Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 down-regulated
miR-98 Curcumin NULL 969516 Microarray BxPC-3 human pancreatic carcinoma cell line 18347134 2008 down-regulated
miR-98 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
miR-98 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR MCF-7 breast cancer cells 19528081 2009 up-regulated
miR-98 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-98 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 201