miRTarBase - #MIRT004488


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pre-miRNA Information
pre-miRNA hsa-mir-16-2   
Genomic Coordinates chr3: 160404745 - 160404825
Description Homo sapiens miR-16-2 stem-loop
Comment This entry represents a second putative hairpin precursor sequence for miR-16, located on chromosome 3 (see also MIR:MI0000070). The sequence was previously named mir-16-3 here and in references .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-16-2-3p
Sequence 53| CCAAUAUUACUGUGCUGCUUUA |74
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30477465 2 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs746992239 2 dbSNP
rs775368833 4 dbSNP
rs373202341 10 dbSNP
rs768780684 13 dbSNP
rs1341798864 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RARB   
Synonyms HAP, MCOPS12, NR1B2, RARbeta1, RRB2
Description retinoic acid receptor beta
Transcript NM_000965   
Other Transcripts NM_016152   
Expression
Putative miRNA Targets on RARB
3'UTR of RARB
(miRNA target sites are highlighted)		 
>RARB|NM_000965|3'UTR
   1 GACATTTTCTAGCTACTTCAAACATTCCCCAGTACCTTCAGTTCCAGGATTTAAAATGCAAGAAAAAACATTTTTACTGC
  81 TGCTTAGTTTTTGGACTGAAAAGATATTAAAACTCAAGAAGGACCAAGAAGTTTTCATATGTATCAATATATATACTCCT
 161 CACTGTGTAACTTACCTAGAAATACAAACTTTTCCAATTTTAAAAAATCAGCCATTTCATGCAACCAGAAACTAGTTAAA
 241 AGCTTCTATTTTCCTCTTTGAACACTCAAGATTGCATGGCAAAGACCCAGTCAAAATGATTTACCCCTGGTTAAGTTTCT
 321 GAAGACTTTGTACATACAGAAGTATGGCTCTGTTCTTTCTATACTGTATGTTTGGTGCTTTCCTTTTGTCTTGCATACTC
 401 AAAATAACCATGACACCAAGGTTATGAAATAGACTACTGTACACGTCTACCTAGGTTCAAAAAGATAACTGTCTTGCTTT
 481 CATGGAATAGTCAAGACATCAAGGTAAGGAAACAGGACTATTGACAGGACTATTGTACAGTATGACAAGATAAGGCTGAA
 561 GATATTCTACTTTAGTTAGTATGGAAGCTTGTCTTTGCTCTTTCTGATGCTCTCAAACTGCATCTTTTATTTCATGTTGC
 641 CCAGTAAAAGTATACAAATTCCCTGCACTAGCAGAAGAGAATTCTGTATCAGTGTAACTGCCAGTTCAGTTAATCAAATG
 721 TCATTTGTTCAATTGTTAATGTCACTTTAAATTAAAAGTGGTTTATTACTTGTTTAATGACATAACTACACAGTTAGTTA
 801 AAAAAAATTTTTTTACAGTAATGATAGCCTCCAAGGCAGAAACACTTTTCAGTGTTAAGTTTTTGTTTACTTGTTCACAA
 881 GCCATTAGGGAAATTTCATGGGATAATTAGCAGGCTGGTCTACCACCTGGACCATGTAACTCTAGTGTCCTTCCTGATTC
 961 ATGCCTGATATTGGGATTTTTTTTTCCAGCCTTCTTGATGCCAAGGGGCTAATTAATATTAACAACTCCCAAAGAAACAG
1041 GCATAGAATCTGCCTCCTTTGACCTTGTTCAATCACTATGAAGCAGAGTGAAAGCTGTGGTAGAGTGGTTAACAGATACA
1121 AGTGTCAGTTTCTTAGTTCTCATTTAAGCACTAGTGGAATTTTTTTTTTTTGATATATTAGCAAGTCTGTGATGTACTTT
1201 CACTGGCTCTGTTTGTACATTGAGATTGTTTGTTTAACAATGCTTTCTATGTTCATATACTGTTTACCTTTTTCCATGGA
1281 GTCTCCTGGCAAAGAATAAAATATATTTATTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
1361 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auUUCGUCGUGUCAUUAUAAcc 5'
            ||| :||  | |||||||  
Target 5' ccAAGGGGCTAATTAATATTaa 3'
 1001 - 1022 144.00 -6.20
2 
miRNA  3' auUUCGUCGUGUCAUUAUAACc 5'
            ||| |  |||| | ||||| 
Target 5' gtAAGGA-AACAGGACTATTGa 3'
 504 - 524 131.00 -8.70
3 
miRNA  3' auuucgucGUGU-CAUUAUAACc 5'
                  ||::  |:|||||| 
Target 5' tcctgattCATGCCTGATATTGg 3'
 952 - 974 130.00 -8.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN1943336 14 COSMIC
COSN30110775 29 COSMIC
COSN31500386 30 COSMIC
COSN30467530 49 COSMIC
COSN30507339 69 COSMIC
COSN28139711 98 COSMIC
COSN31608249 104 COSMIC
COSN28864713 140 COSMIC
COSN30722137 155 COSMIC
COSN7760117 162 COSMIC
COSN30169237 268 COSMIC
COSN23245070 375 COSMIC
COSN31549903 395 COSMIC
COSN28140135 473 COSMIC
COSN31532300 483 COSMIC
COSN26689919 568 COSMIC
COSN31520393 656 COSMIC
COSN20098222 798 COSMIC
COSN31584166 808 COSMIC
COSN24299634 809 COSMIC
COSN31606843 810 COSMIC
COSN20607735 932 COSMIC
COSN26639297 946 COSMIC
COSN20098228 1040 COSMIC
COSN7603390 1069 COSMIC
COSN25156343 1096 COSMIC
COSN30161564 1103 COSMIC
COSN29002201 1158 COSMIC
COSN1275283 1172 COSMIC
COSN27507922 1172 COSMIC
COSN31566102 1244 COSMIC
rs116199914 249 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs150640333 5 dbSNP
rs1231325075 11 dbSNP
rs927788295 14 dbSNP
rs760021600 16 dbSNP
rs1414131688 17 dbSNP
rs768047630 18 dbSNP
rs752865177 20 dbSNP
rs1248578346 22 dbSNP
rs1402279601 24 dbSNP
rs111671607 25 dbSNP
rs1397485001 26 dbSNP
rs756213540 28 dbSNP
rs369611883 30 dbSNP
rs990674425 33 dbSNP
rs1409725863 34 dbSNP
rs754044677 36 dbSNP
rs1352669238 37 dbSNP
rs1231554572 51 dbSNP
rs1207049231 59 dbSNP
rs558545649 63 dbSNP
rs185533944 67 dbSNP
rs916251369 69 dbSNP
rs534469545 70 dbSNP
rs1407637287 73 dbSNP
rs28509419 84 dbSNP
rs1373071836 89 dbSNP
rs554355759 92 dbSNP
rs1246083970 94 dbSNP
rs1440835262 95 dbSNP
rs952686359 97 dbSNP
rs1330406778 100 dbSNP
rs1335591626 102 dbSNP
rs574334526 105 dbSNP
rs1432049752 108 dbSNP
rs1371601587 114 dbSNP
rs1173376967 122 dbSNP
rs1453178078 126 dbSNP
rs1427859313 128 dbSNP
rs79679061 129 dbSNP
rs190921496 134 dbSNP
rs577416577 137 dbSNP
rs1296250909 138 dbSNP
rs976499292 140 dbSNP
rs935060170 142 dbSNP
rs1225129391 143 dbSNP
rs1279161607 152 dbSNP
rs746455367 164 dbSNP
rs1370477959 168 dbSNP
rs550782092 171 dbSNP
rs1410105671 173 dbSNP
rs546194290 174 dbSNP
rs1325673166 176 dbSNP
rs1312721322 178 dbSNP
rs1433173054 180 dbSNP
rs182678391 183 dbSNP
rs1177359896 186 dbSNP
rs1400228191 186 dbSNP
rs866195693 192 dbSNP
rs1405939780 193 dbSNP
rs1161437067 202 dbSNP
rs1224365883 202 dbSNP
rs932317887 209 dbSNP
rs1257075108 210 dbSNP
rs1053312014 219 dbSNP
rs1049980704 220 dbSNP
rs754625858 229 dbSNP
rs926174096 234 dbSNP
rs1215031606 247 dbSNP
rs901315445 247 dbSNP
rs116199914 249 dbSNP
rs1269534689 249 dbSNP
rs77458929 259 dbSNP
rs1381742414 267 dbSNP
rs891966943 276 dbSNP
rs1303764151 281 dbSNP
rs1430710944 287 dbSNP
rs748532131 288 dbSNP
rs1343938087 293 dbSNP
rs753225214 308 dbSNP
rs1161551063 309 dbSNP
rs764751279 310 dbSNP
rs1417432860 313 dbSNP
rs770242021 317 dbSNP
rs1162996726 322 dbSNP
rs1005589807 324 dbSNP
rs562262449 325 dbSNP
rs961512913 328 dbSNP
rs972763611 338 dbSNP
rs1034834829 340 dbSNP
rs1484890676 347 dbSNP
rs1045808670 351 dbSNP
rs960489861 353 dbSNP
rs79215662 354 dbSNP
rs1208819195 360 dbSNP
rs767626769 362 dbSNP
rs1246590381 365 dbSNP
rs1321928695 366 dbSNP
rs1313964669 367 dbSNP
rs1446989409 382 dbSNP
rs916533702 383 dbSNP
rs1363650729 390 dbSNP
rs539214127 395 dbSNP
rs946625112 406 dbSNP
rs1323071183 409 dbSNP
rs1435938424 411 dbSNP
rs1001474226 412 dbSNP
rs1459691567 417 dbSNP
rs531156615 418 dbSNP
rs549884153 419 dbSNP
rs865926884 421 dbSNP
rs116830066 424 dbSNP
rs1391968134 431 dbSNP
rs1189088098 437 dbSNP
rs1453688903 442 dbSNP
rs1480446293 443 dbSNP
rs538225518 445 dbSNP
rs935111817 446 dbSNP
rs1015802044 448 dbSNP
rs1040105836 450 dbSNP
rs1204283797 451 dbSNP
rs961243188 452 dbSNP
rs1340419365 455 dbSNP
rs1229839661 465 dbSNP
rs1300488684 465 dbSNP
rs201783636 466 dbSNP
rs1375531569 467 dbSNP
rs756444113 472 dbSNP
rs1299367315 478 dbSNP
rs901348082 491 dbSNP
rs934179842 493 dbSNP
rs1297770334 509 dbSNP
rs1427612074 510 dbSNP
rs552675376 512 dbSNP
rs1168971037 513 dbSNP
rs566186144 515 dbSNP
rs754210363 516 dbSNP
rs953799736 522 dbSNP
rs1433204611 524 dbSNP
rs988332177 525 dbSNP
rs1175078590 530 dbSNP
rs1383958948 531 dbSNP
rs925681866 533 dbSNP
rs1380528117 541 dbSNP
rs1206306816 547 dbSNP
rs138745362 547 dbSNP
rs890067360 550 dbSNP
rs1254712339 556 dbSNP
rs1235535986 559 dbSNP
rs1331709086 566 dbSNP
rs1304816232 579 dbSNP
rs1347488953 583 dbSNP
rs1408283732 584 dbSNP
rs1352552348 585 dbSNP
rs1006203851 589 dbSNP
rs1413873531 592 dbSNP
rs1038386237 598 dbSNP
rs1400002331 598 dbSNP
rs1053382285 604 dbSNP
rs897124674 607 dbSNP
rs1362754597 610 dbSNP
rs1156290644 616 dbSNP
rs1473406541 620 dbSNP
rs1252000423 621 dbSNP
rs773416762 621 dbSNP
rs1183370532 624 dbSNP
rs1485521147 625 dbSNP
rs1254719550 646 dbSNP
rs1282687840 647 dbSNP
rs1310715724 649 dbSNP
rs1241436062 657 dbSNP
rs1346297035 658 dbSNP
rs994215861 660 dbSNP
rs913363613 665 dbSNP
rs1350324492 667 dbSNP
rs1226647321 669 dbSNP
rs1331494459 670 dbSNP
rs1335906160 673 dbSNP
rs373252864 673 dbSNP
rs757706750 673 dbSNP
rs1271622974 675 dbSNP
rs1035034297 679 dbSNP
rs565798103 682 dbSNP
rs1264629307 684 dbSNP
rs757128494 684 dbSNP
rs937458028 687 dbSNP
rs1049046280 688 dbSNP
rs377355554 688 dbSNP
rs1005845717 695 dbSNP
rs1159376193 696 dbSNP
rs1471585435 698 dbSNP
rs1367135610 701 dbSNP
rs1012075896 704 dbSNP
rs1190030448 708 dbSNP
rs1443569705 710 dbSNP
rs1206924012 712 dbSNP
rs779025563 712 dbSNP
rs1466274271 713 dbSNP
rs1023873420 717 dbSNP
rs1015523313 718 dbSNP
rs1354482649 731 dbSNP
rs968023673 731 dbSNP
rs534911648 734 dbSNP
rs1245160131 739 dbSNP
rs546188032 741 dbSNP
rs1325798586 744 dbSNP
rs1366151676 747 dbSNP
rs201492992 749 dbSNP
rs745367643 749 dbSNP
rs1293073911 752 dbSNP
rs567400066 754 dbSNP
rs745894688 754 dbSNP
rs1165371805 756 dbSNP
rs1473299762 765 dbSNP
rs1390130833 766 dbSNP
rs1365572635 770 dbSNP
rs757967908 770 dbSNP
rs1393363832 776 dbSNP
rs1307907879 783 dbSNP
rs554492457 783 dbSNP
rs1029530400 784 dbSNP
rs1450085032 784 dbSNP
rs953774072 787 dbSNP
rs979731507 788 dbSNP
rs10548794 792 dbSNP
rs1338461228 792 dbSNP
rs35219452 792 dbSNP
rs533975133 792 dbSNP
rs774577588 792 dbSNP
rs1230577328 796 dbSNP
rs1365817811 797 dbSNP
rs56768779 797 dbSNP
rs749492135 797 dbSNP
rs1491368759 798 dbSNP
rs923631240 798 dbSNP
rs985210350 799 dbSNP
rs1167076440 800 dbSNP
rs58499503 800 dbSNP
rs1432234514 803 dbSNP
rs188986088 808 dbSNP
rs545264042 808 dbSNP
rs923054163 809 dbSNP
rs1199901396 812 dbSNP
rs931701113 819 dbSNP
rs1272279912 820 dbSNP
rs1207027410 821 dbSNP
rs146684489 822 dbSNP
rs772418347 840 dbSNP
rs1222387352 851 dbSNP
rs878933939 851 dbSNP
rs1216995970 853 dbSNP
rs1346461291 853 dbSNP
rs200244003 854 dbSNP
rs1441089758 856 dbSNP
rs950335483 856 dbSNP
rs201349875 857 dbSNP
rs755954727 857 dbSNP
rs759019717 857 dbSNP
rs927503488 862 dbSNP
rs1413233908 871 dbSNP
rs1177445608 877 dbSNP
rs1427408926 882 dbSNP
rs1049949764 886 dbSNP
rs1249331611 889 dbSNP
rs1173217295 892 dbSNP
rs557003083 896 dbSNP
rs544555643 898 dbSNP
rs1472423455 901 dbSNP
rs1249804279 902 dbSNP
rs1184097590 903 dbSNP
rs1483234424 904 dbSNP
rs1236871444 907 dbSNP
rs937385838 915 dbSNP
rs1437398513 916 dbSNP
rs1227242518 918 dbSNP
rs193139742 918 dbSNP
rs941640257 927 dbSNP
rs887745179 933 dbSNP
rs970692581 934 dbSNP
rs1385618025 937 dbSNP
rs1424011940 940 dbSNP
rs1162517359 941 dbSNP
rs1038988060 942 dbSNP
rs897057264 943 dbSNP
rs1456717541 947 dbSNP
rs1240706661 948 dbSNP
rs998141634 949 dbSNP
rs113191461 950 dbSNP
rs375568160 952 dbSNP
rs889632362 955 dbSNP
rs1006616968 956 dbSNP
rs199576341 956 dbSNP
rs1237919701 960 dbSNP
rs1032782614 963 dbSNP
rs1463129864 965 dbSNP
rs113216805 972 dbSNP
rs779551528 975 dbSNP
rs1020406829 977 dbSNP
rs140956529 977 dbSNP
rs1056390486 979 dbSNP
rs971616127 981 dbSNP
rs573202997 985 dbSNP
rs542517908 986 dbSNP
rs1434506830 988 dbSNP
rs1386600764 991 dbSNP
rs562401762 993 dbSNP
rs1012275393 995 dbSNP
rs531089631 1004 dbSNP
rs927430391 1006 dbSNP
rs868764581 1007 dbSNP
rs1162442096 1009 dbSNP
rs981189487 1009 dbSNP
rs1414482644 1010 dbSNP
rs1187892317 1011 dbSNP
rs1311141301 1012 dbSNP
rs1249406706 1014 dbSNP
rs1487956401 1015 dbSNP
rs985255417 1015 dbSNP
rs1308779091 1017 dbSNP
rs183022432 1018 dbSNP
rs940800179 1021 dbSNP
rs371314595 1024 dbSNP
rs55887864 1024 dbSNP
rs1000794989 1029 dbSNP
rs1367189594 1030 dbSNP
rs1051022799 1031 dbSNP
rs3832215 1035 dbSNP
rs397934113 1035 dbSNP
rs866092236 1035 dbSNP
rs56197612 1036 dbSNP
rs1427815961 1038 dbSNP
rs1247118010 1039 dbSNP
rs1250242330 1040 dbSNP
rs1391865913 1040 dbSNP
rs1456213245 1041 dbSNP
rs1205170522 1042 dbSNP
rs1432040980 1043 dbSNP
rs1264868493 1045 dbSNP
rs1031368132 1049 dbSNP
rs1443720106 1052 dbSNP
rs1054726519 1056 dbSNP
rs892876120 1058 dbSNP
rs563186488 1060 dbSNP
rs368368463 1069 dbSNP
rs750175723 1069 dbSNP
rs1421524250 1071 dbSNP
rs1429017840 1072 dbSNP
rs532241522 1072 dbSNP
rs1003052820 1078 dbSNP
rs1399630955 1079 dbSNP
rs1307185082 1080 dbSNP
rs1407702800 1082 dbSNP
rs1372353924 1087 dbSNP
rs552029959 1087 dbSNP
rs1034584425 1089 dbSNP
rs1465459614 1090 dbSNP
rs1375478099 1094 dbSNP
rs1177588118 1095 dbSNP
rs1480599913 1100 dbSNP
rs878956440 1102 dbSNP
rs958971494 1103 dbSNP
rs1464327212 1104 dbSNP
rs1254376530 1106 dbSNP
rs1196931622 1108 dbSNP
rs1254403650 1109 dbSNP
rs975768183 1109 dbSNP
rs1235426221 1114 dbSNP
rs922918341 1116 dbSNP
rs1447704423 1120 dbSNP
rs531631961 1122 dbSNP
rs1352143463 1123 dbSNP
rs1364754080 1124 dbSNP
rs746611789 1125 dbSNP
rs1304089799 1129 dbSNP
rs1215650696 1132 dbSNP
rs1387486639 1134 dbSNP
rs1156457676 1142 dbSNP
rs1473354400 1143 dbSNP
rs565670632 1144 dbSNP
rs911398327 1153 dbSNP
rs1365969180 1157 dbSNP
rs10638799 1160 dbSNP
rs1243713627 1160 dbSNP
rs1338645759 1160 dbSNP
rs1439789308 1160 dbSNP
rs941491895 1161 dbSNP
rs1277092560 1166 dbSNP
rs972566276 1170 dbSNP
rs200240335 1172 dbSNP
rs923238834 1172 dbSNP
rs1224978648 1173 dbSNP
rs1159522608 1174 dbSNP
rs1263323836 1176 dbSNP
rs575026903 1176 dbSNP
rs1038530217 1178 dbSNP
rs918880610 1180 dbSNP
rs1247555979 1182 dbSNP
rs1445743401 1182 dbSNP
rs1186752546 1183 dbSNP
rs1207806093 1183 dbSNP
rs1448962040 1185 dbSNP
rs578226135 1188 dbSNP
rs911127294 1190 dbSNP
rs1266960167 1194 dbSNP
rs1486189129 1195 dbSNP
rs1185859063 1196 dbSNP
rs1294766272 1197 dbSNP
rs1436569382 1207 dbSNP
rs930211402 1207 dbSNP
rs766234734 1210 dbSNP
rs1322420818 1211 dbSNP
rs751097260 1212 dbSNP
rs896464899 1216 dbSNP
rs1178886792 1223 dbSNP
rs547880212 1226 dbSNP
rs757216357 1226 dbSNP
rs1166810790 1229 dbSNP
rs753382197 1230 dbSNP
rs1430290787 1231 dbSNP
rs1242948596 1233 dbSNP
rs375252094 1236 dbSNP
rs1450066180 1241 dbSNP
rs1270860690 1242 dbSNP
rs1174465852 1243 dbSNP
rs528105037 1244 dbSNP
rs1432116312 1257 dbSNP
rs1325488267 1261 dbSNP
rs547979161 1261 dbSNP
rs1298061116 1263 dbSNP
rs1337804497 1274 dbSNP
rs781066188 1274 dbSNP
rs747969045 1280 dbSNP
rs1406205675 1282 dbSNP
rs948160887 1284 dbSNP
rs879824030 1287 dbSNP
rs1058378 1288 dbSNP
rs1305344832 1288 dbSNP
rs752432871 1291 dbSNP
rs903927925 1294 dbSNP
rs1001145201 1298 dbSNP
rs1006924323 1299 dbSNP
rs1420382007 1300 dbSNP
rs1030814538 1302 dbSNP
rs1016398371 1304 dbSNP
rs1477163436 1304 dbSNP
rs868153550 1313 dbSNP
rs1199904792 1314 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCE-4 , HCE-7 , SKGT-4 , TE-3
Disease 5915.0;
Original Description (Extracted from the article) ... "We also found that miR-34a was able to suppress c-Met and cyclin D1 expression and proliferation of esophageal cancer cell lines ...

- Hu Y; Correa AM; Hoque A; Guan B; Ye F; et al., 2011, International journal of cancer.

Article - Hu Y; Correa AM; Hoque A; Guan B; Ye F; et al.
- International journal of cancer, 2011
Altered microRNA (miRNA) expression has been found to promote carcinogenesis, but little is known about the role of miRNAs in esophageal cancer. In this study, we selected 10 miRNAs and analyzed their expression in 10 esophageal cancer cell lines and 158 tissue specimens using Northern blotting and in situ hybridization, respectively. We found that Let-7g, miR-21 and miR-195p were expressed in all 10 cell lines, miR-9 and miR-20a were not expressed in any of the cell lines, and miR-16-2, miR-30e, miR-34a, miR-126 and miR-200a were expressed in some of the cell lines but not others. In addition, transient transfection of miR-34a inhibited c-Met and cyclin D1 expression and esophageal cancer cell proliferation, whereas miR-16-2 suppressed RAR-beta(2) expression and increased tumor cell proliferation. Furthermore, we found that miR-126 expression was associated with tumor cell dedifferentiation and lymph node metastasis, miR-16-2 was associated with lymph node metastasis, and miR-195p was associated with higher pathologic disease stages in patients with esophageal adenocarcinoma. Kaplan-Meier analysis showed that miR-16-2 expression and miR-30e expression were associated with shorter overall and disease-free survival in all esophageal cancer patients. In addition, miR-16-2, miR-30e and miR-200a expression were associated with shorter overall and disease-free survival in patients with esophageal adenocarcinoma; however, miR-16-2, miR-30e and miR-200a expression were not associated with overall or disease-free survival in squamous cell carcinoma patients. Our data indicate that further evaluation of miR-30e and miR-16-2 as prognostic biomarkers is warranted in patients with esophageal adenocarcinoma. In addition, the role of miR-34a in esophageal cancer also warrants further study.
LinkOut: [PMID: 20309880]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.762 1.2e-3 0.764 1.2e-3 13 Click to see details
GSE19783 ER- ER- breast cancer 0.22 2.6e-2 0.200 3.9e-2 79 Click to see details
GSE19536 Breast cancer 0.193 2.7e-2 0.164 5.2e-2 100 Click to see details
GSE28544 Breast cancer 0.358 4.3e-2 0.595 1.1e-3 24 Click to see details
GSE32688 Pancreatic cancer 0.25 8.4e-2 0.208 1.3e-1 32 Click to see details
GSE21687 Ependynoma primary tumors 0.173 8.6e-2 0.198 5.8e-2 64 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.457 1.1e-1 -0.250 2.6e-1 9 Click to see details
GSE42095 Differentiated embryonic stem cells 0.256 1.2e-1 0.237 1.4e-1 23 Click to see details
GSE21032 Prostate cancer -0.128 1.2e-1 -0.089 2.1e-1 83 Click to see details
GSE17498 Multiple myeloma -0.174 1.4e-1 0.080 3.1e-1 40 Click to see details
GSE38226 Liver fibrosis 0.188 2.1e-1 -0.166 2.4e-1 21 Click to see details
GSE19783 ER+ ER+ breast cancer 0.186 2.2e-1 0.021 4.6e-1 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.098 3.2e-1 0.168 2.1e-1 25 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.091 3.5e-1 0.192 2.1e-1 20 Click to see details
GSE26953 Aortic valvular endothelial cells 0.073 3.7e-1 0.237 1.3e-1 24 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.053 4.0e-1 0.005 4.9e-1 25 Click to see details
GSE19350 CNS germ cell tumors 0.061 4.3e-1 0.000 5.0e-1 12 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRC -0.321 0 -0.299 0.01 68 Click to see details
STAD -0.44 0.01 -0.465 0 31 Click to see details
KICH -0.379 0.03 -0.334 0.05 25 Click to see details
BRCA -0.187 0.05 -0.278 0.01 83 Click to see details
HNSC -0.203 0.1 -0.232 0.07 42 Click to see details
ESCA -0.412 0.1 -0.427 0.1 11 Click to see details
LIHC -0.143 0.16 -0.168 0.12 49 Click to see details
PAAD -0.644 0.18 -0.800 0.1 4 Click to see details
CHOL 0.313 0.21 0.500 0.09 9 Click to see details
KIRP 0.149 0.21 0.240 0.09 32 Click to see details
LUAD -0.256 0.21 -0.385 0.11 12 Click to see details
PCPG -0.579 0.3 -0.500 0.33 3 Click to see details
CESC -0.513 0.33 -0.500 0.33 3 Click to see details
BLCA -0.104 0.34 -0.170 0.25 18 Click to see details
LUSC 0.065 0.35 0.051 0.38 38 Click to see details
UCEC -0.076 0.38 -0.088 0.36 19 Click to see details
THCA -0.021 0.44 -0.008 0.48 59 Click to see details
PRAD -0.023 0.44 -0.067 0.33 48 Click to see details
PRAD -0.023 0.44 -0.067 0.33 48 Click to see details
PRAD -0.023 0.44 -0.067 0.33 48 Click to see details
75 hsa-miR-16-2-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT004488 RARB retinoic acid receptor beta 3 1
MIRT038707 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 1 1
MIRT057208 PPIF peptidylprolyl isomerase F 2 4
MIRT058726 RSBN1 round spermatid basic protein 1 2 8
MIRT074502 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 4
MIRT081544 ZNF431 zinc finger protein 431 2 4
MIRT096893 ERBB2IP erbb2 interacting protein 2 2
MIRT105124 MYC MYC proto-oncogene, bHLH transcription factor 2 2
MIRT107898 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 4
MIRT109432 KLHL15 kelch like family member 15 2 6
MIRT166742 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 6
MIRT171257 YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma 2 2
MIRT192760 B2M beta-2-microglobulin 2 2
MIRT194905 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT215599 SUB1 SUB1 homolog, transcriptional regulator 2 2
MIRT223632 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT241605 AMOTL1 angiomotin like 1 2 4
MIRT291174 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT444286 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT463285 ZFX zinc finger protein, X-linked 2 4
MIRT471759 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT479611 CDC25A cell division cycle 25A 2 2
MIRT481497 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 8
MIRT483117 SH3BP5 SH3 domain binding protein 5 2 2
MIRT502279 GRPEL2 GrpE like 2, mitochondrial 2 8
MIRT507838 CCNT1 cyclin T1 2 2
MIRT508179 MTRNR2L6 MT-RNR2-like 6 2 4
MIRT510576 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 6
MIRT517853 RPS4X ribosomal protein S4, X-linked 2 4
MIRT521690 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 8
MIRT525070 FRK fyn related Src family tyrosine kinase 2 2
MIRT527082 UBE2E3 ubiquitin conjugating enzyme E2 E3 2 2
MIRT529552 EI24 EI24, autophagy associated transmembrane protein 2 2
MIRT530426 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT533909 TBC1D15 TBC1 domain family member 15 2 2
MIRT536627 IPO7 importin 7 2 2
MIRT537647 ERGIC2 ERGIC and golgi 2 2 4
MIRT538512 CLCN3 chloride voltage-gated channel 3 2 2
MIRT539219 ANP32E acidic nuclear phosphoprotein 32 family member E 2 6
MIRT539348 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT539954 CCT4 chaperonin containing TCP1 subunit 4 2 2
MIRT541208 HOXA10 homeobox A10 2 2
MIRT543216 TMEM117 transmembrane protein 117 2 2
MIRT543399 DROSHA drosha ribonuclease III 2 2
MIRT546648 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT546852 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT549917 MRPS30 mitochondrial ribosomal protein S30 2 2
MIRT552998 USP46 ubiquitin specific peptidase 46 2 2
MIRT555254 PREPL prolyl endopeptidase-like 2 2
MIRT555956 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT557095 HOXA9 homeobox A9 2 2
MIRT561396 TUBB2A tubulin beta 2A class IIa 2 2
MIRT561654 RNF219 ring finger protein 219 2 2
MIRT563101 PABPC4L poly(A) binding protein cytoplasmic 4 like 2 2
MIRT565979 RNF44 ring finger protein 44 2 2
MIRT572396 CCDC14 coiled-coil domain containing 14 2 2
MIRT574400 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT607623 VSNL1 visinin like 1 2 2
MIRT610645 CTGF connective tissue growth factor 2 2
MIRT623379 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT624687 AR androgen receptor 2 2
MIRT632089 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT644216 CBS cystathionine-beta-synthase 2 2
MIRT647841 BID BH3 interacting domain death agonist 2 2
MIRT651649 WASF2 WAS protein family member 2 2 2
MIRT689064 AGMAT agmatinase 2 2
MIRT698150 TNPO1 transportin 1 2 2
MIRT700516 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT704081 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT705970 ACBD5 acyl-CoA binding domain containing 5 2 2
MIRT715694 COMMD3-BMI1 COMMD3-BMI1 readthrough 2 2
MIRT717184 BMI1 BMI1 proto-oncogene, polycomb ring finger 2 2
MIRT724607 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT724854 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT725401 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-16-2 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-16-2-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HCT-116)
hsa-miR-16-2-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-16-2-3p Bortezomib 387447 NSC681239 approved resistant Low Multiple Myeloma tissue
hsa-miR-16-2-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-16-2-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-16-2-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-16-2-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (HCT8)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (MDA-231)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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