miRTarBase - #MIRT005383


—
pre-miRNA Information
pre-miRNA hsa-mir-29b-1   
Genomic Coordinates chr7: 130877459 - 130877539
Synonyms MIRN29B1, miRNA29B1, MIR29B1
Description Homo sapiens miR-29b-1 stem-loop
Comment Mourelatos et al. identified two copies of this sequence mapping to chromosome 7, and assigned the names mir-102-7.1 and mir-102-7.2 . Subsequent genome assemblies suggest the presence of only one miR-102 locus on chromosome 7. Human miR-102 is a homologue of mouse miR-29b (MIR:MI0000143) and so has been renamed here for consistency.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-29b-2   
Genomic Coordinates chr1: 207802443 - 207802523
Synonyms MIRN29B2, mir-29b-2, MIR29B2
Description Homo sapiens miR-29b-2 stem-loop
Comment This sequence was named mir-102-1 in reference . Human miR-102 is a homologue of mouse miR-29b (MIR:MI0000143) and so has been renamed here for consistency.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-29b-3p
Sequence 52| UAGCACCAUUUGAAAUCAGUGUU |74
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 7 - 130877488 29233923 MiREDiBase
A-to-I 2 1 - 207802471 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs773555186 20 dbSNP
rs1390817128 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MMP15   
Synonyms MMP-15, MT2-MMP, MT2MMP, MTMMP2, SMCP-2
Description matrix metallopeptidase 15
Transcript NM_002428   
Expression
Putative miRNA Targets on MMP15
3'UTR of MMP15
(miRNA target sites are highlighted)		 
>MMP15|NM_002428|3'UTR
   1 CCACCCAGCGCTCCTGCTAACGGTGCTCAGGGGGCGCCTGTGGTTCTGAGATGGCTCCCAGGGGCTCCCTCCGCCCCCAG
  81 GTAGGGGCCCCTCTCAGCCCTCACACACCCTGTCTGCCCCGCCCTCATTATTTATGTCCAGGTGTTTGTTTTGTTTTGTT
 161 TTTGGCACCTTACTTGACCATTTGTTTCTGTTTCCCCGACTGGGGCAGGGTGTTTAGAATTTTCTAAATGTAGTTCTGCT
 241 CCAGACAGGGAATTAGGCCCCCATCATCCTCTGGCTTGGCCACAGCCAGGGGAGCAGAGGGGCAGAGGCCCACATTGGAA
 321 GAGCAGCACCTCCTCAGCCTGAACCCCAGGGCTGTAACTGCCAGGCTCTCTTTGCCCAGTTGGAGACTGTCTGGCCCCCC
 401 TGGTCCCCTCCTTCCCAAGTGAGTCTCTCTGGGCCTTAGGAAGAGCCTTCCACCCAGGGGCAGCCCCAGGCCAAAGGGGA
 481 CCTGGAAGGGAGGTGGGCCGTGGCCCTTGAGTCCCCATTGAGGCTTGGTTCCTTCCCAATCCAGTGGACTTCGCAGTCCA
 561 CTTCTGACAGCCTCAGTGACCCTGGCTCCTTGTGCCAGAGAACCCAGCCCACCCCCGGCAGCAGCCCCCAGCTCCCACCT
 641 CCCCTTGGGCCCACACCTCCTTCCCTCTCTGGAGAAAGGGCCCTGGGCCTGCCTCACCACGGACCAAAGGGAGTCTGCCA
 721 GGGCCCCTCTCCCCAGGGAAGCAGCAGCCTCGCCCCTGGCAGAGATGCCTCCCTGAGCTAGAACCCTCTGTTCCTTCCCT
 801 GTGCCTCCTCCCTCCCTCTCCGACTCACACCACTAGCCTCAGGGGTCTGAGCTCCAGCTCCTTTGGGCTTCAGCTGCCAG
 881 TGTCCTGAGCCCCAGGGAGAGGGGGCTGGTGGGTGCCTAGGCCTGGGCAGTGGATGGCCGTGAATGGGTGCCCACAGTGT
 961 CAGGCACTGGGCATGAGGGGTTCCTCCCCTCCAGCTCCCTGTGCCCCCAGGGTCCTGGGAGGAGAGACACTGGTGGGGAT
1041 AGGCCAGCCGCGCATCAGACTGTGAACCCCACGAAGGAGCCCATTGTGGCCTAAGAGGCTGCCCTCCTGTGCTCAGCCCT
1121 GAGGACAGATGCCTCCTTCCTCTTTTCCTTCCCAAAGCAAGCAAGAGGCCGTGGCTGCTGTGGGAAATGGTACTGTACAG
1201 CTGGCTCTACTTCCCCATGGCCCTGAGCGAGTGGAGTCTGCCACCCAGGATCCCCAAGGCACTTGAGGGGGAAGGATTCT
1281 GCTGGCCTCTGCGAGTGGTTTCTTGTGCACTGGCACCAAGTGCGGGTCCGGCAGCTTCTGCCCCCTGCAGAACCGGAGAG
1361 CCAGCTAAGGGGTGGGGCTGCGGGGGTTCCGTGTCCACCCCCATACATTTATTTCTGTAAATAATGTGCACTGAATAAAT
1441 TGTACAGCCGGCAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uugUGACUAAA--GUUUACCACGAu 5'
             :||| | |   ||||||| || 
Target 5' gtgGCTGCTGTGGGAAATGGTACTg 3'
 1171 - 1195 130.00 -11.60
2 
miRNA  3' uuGUGACUAAAGUUUACCACGAu 5'
            |:||   | | || |||||| 
Target 5' agCGCT-CCTGCTAACGGTGCTc 3'
 7 - 28 124.00 -11.10
3 
miRNA  3' uuGUGACUAAAGUUUACCACGAu 5'
            :|:| || || |  ||||:| 
Target 5' atTATTTATGTCCA--GGTGTTt 3'
 127 - 147 116.00 -6.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30139944 26 COSMIC
COSN30119903 36 COSMIC
COSN22692918 430 COSMIC
COSN24965193 616 COSMIC
COSN6646343 660 COSMIC
COSN31590224 745 COSMIC
COSN31563467 779 COSMIC
COSN28768119 866 COSMIC
COSN31480889 888 COSMIC
COSN28740005 910 COSMIC
COSN25229767 1001 COSMIC
COSN21977552 1093 COSMIC
COSN31597604 1201 COSMIC
COSN24305496 1221 COSMIC
COSN30164616 1339 COSMIC
COSN24305758 1382 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs945775579 1 dbSNP
rs1329016786 3 dbSNP
rs768624058 6 dbSNP
rs1265153547 9 dbSNP
rs113877220 10 dbSNP
rs376623496 11 dbSNP
rs774334502 12 dbSNP
rs901711003 14 dbSNP
rs1481492752 15 dbSNP
rs1490085842 16 dbSNP
rs1241758265 19 dbSNP
rs368575241 19 dbSNP
rs1410935309 20 dbSNP
rs767772197 22 dbSNP
rs994682022 23 dbSNP
rs376333947 24 dbSNP
rs150382270 27 dbSNP
rs1413359550 33 dbSNP
rs766859508 34 dbSNP
rs761056257 36 dbSNP
rs41324945 37 dbSNP
rs1309084291 38 dbSNP
rs1363707379 52 dbSNP
rs1157499946 53 dbSNP
rs1327100219 59 dbSNP
rs993611100 61 dbSNP
rs1025047376 71 dbSNP
rs41496151 73 dbSNP
rs754219207 74 dbSNP
rs1218126035 79 dbSNP
rs988386494 81 dbSNP
rs1259650361 87 dbSNP
rs1269156132 89 dbSNP
rs1213504453 92 dbSNP
rs926877626 96 dbSNP
rs767142184 97 dbSNP
rs548639606 98 dbSNP
rs750059510 99 dbSNP
rs990239364 101 dbSNP
rs1280391955 106 dbSNP
rs914208135 108 dbSNP
rs1384298430 117 dbSNP
rs1214130838 121 dbSNP
rs570083279 122 dbSNP
rs975570805 125 dbSNP
rs923021782 128 dbSNP
rs1194812379 145 dbSNP
rs1426741190 145 dbSNP
rs1468605110 145 dbSNP
rs1428777514 148 dbSNP
rs138174529 150 dbSNP
rs1261888085 155 dbSNP
rs1484194677 157 dbSNP
rs553678533 161 dbSNP
rs1422707855 162 dbSNP
rs1050234109 163 dbSNP
rs889050381 164 dbSNP
rs1006110047 170 dbSNP
rs1228346156 184 dbSNP
rs879152832 185 dbSNP
rs1326088013 191 dbSNP
rs552173623 198 dbSNP
rs865870145 199 dbSNP
rs1384144497 201 dbSNP
rs1419607089 203 dbSNP
rs1468721028 205 dbSNP
rs931778348 206 dbSNP
rs1475301422 209 dbSNP
rs897853506 211 dbSNP
rs1372201642 218 dbSNP
rs1166116021 228 dbSNP
rs1051846466 230 dbSNP
rs1243246037 236 dbSNP
rs911599217 237 dbSNP
rs570762899 243 dbSNP
rs993496319 245 dbSNP
rs1459930830 251 dbSNP
rs1252336758 253 dbSNP
rs1291135802 261 dbSNP
rs1025101095 262 dbSNP
rs1196219336 269 dbSNP
rs534994342 276 dbSNP
rs1002788828 288 dbSNP
rs1247053735 290 dbSNP
rs553292764 293 dbSNP
rs1314493615 297 dbSNP
rs994650908 301 dbSNP
rs1379774944 302 dbSNP
rs1310615034 308 dbSNP
rs1044934311 315 dbSNP
rs755504845 316 dbSNP
rs765744394 318 dbSNP
rs1296045568 327 dbSNP
rs574688858 328 dbSNP
rs1287560302 329 dbSNP
rs1385243450 346 dbSNP
rs914135553 351 dbSNP
rs967055991 357 dbSNP
rs977048430 366 dbSNP
rs879024609 369 dbSNP
rs1035430423 373 dbSNP
rs1437065092 375 dbSNP
rs1326797308 386 dbSNP
rs933045438 388 dbSNP
rs1490575343 389 dbSNP
rs892432347 396 dbSNP
rs1243941394 398 dbSNP
rs910414607 399 dbSNP
rs941840093 400 dbSNP
rs1334311920 401 dbSNP
rs535698710 402 dbSNP
rs1009526159 408 dbSNP
rs1022479101 416 dbSNP
rs1406334047 417 dbSNP
rs1365875138 418 dbSNP
rs1301985414 424 dbSNP
rs1422256851 424 dbSNP
rs574918399 441 dbSNP
rs975538191 442 dbSNP
rs1198250489 446 dbSNP
rs897739693 447 dbSNP
rs1361776956 451 dbSNP
rs1028511963 454 dbSNP
rs1201330922 459 dbSNP
rs953243041 470 dbSNP
rs1268529320 479 dbSNP
rs1046392729 483 dbSNP
rs987274813 500 dbSNP
rs1285086487 501 dbSNP
rs41399651 503 dbSNP
rs1002263761 508 dbSNP
rs1285570554 511 dbSNP
rs1181005473 512 dbSNP
rs1224580019 515 dbSNP
rs1345716401 518 dbSNP
rs41411446 519 dbSNP
rs971744644 524 dbSNP
rs1402741681 528 dbSNP
rs1161970817 538 dbSNP
rs147191739 540 dbSNP
rs1011488240 541 dbSNP
rs930575835 546 dbSNP
rs1045284506 553 dbSNP
rs905065258 554 dbSNP
rs939188478 559 dbSNP
rs1465937184 561 dbSNP
rs966898156 562 dbSNP
rs1056511709 565 dbSNP
rs1476517729 566 dbSNP
rs1242720681 571 dbSNP
rs1192640865 572 dbSNP
rs1377284977 574 dbSNP
rs892568899 575 dbSNP
rs977058232 581 dbSNP
rs1204688964 587 dbSNP
rs1009494886 589 dbSNP
rs1225286163 591 dbSNP
rs1292087932 599 dbSNP
rs1022279869 604 dbSNP
rs1270253723 612 dbSNP
rs780522482 612 dbSNP
rs1429493059 613 dbSNP
rs904092573 614 dbSNP
rs997092594 617 dbSNP
rs375862058 618 dbSNP
rs573136401 626 dbSNP
rs540527389 629 dbSNP
rs910292378 630 dbSNP
rs1411853677 635 dbSNP
rs62041802 645 dbSNP
rs973200475 651 dbSNP
rs1335595232 653 dbSNP
rs955535644 656 dbSNP
rs929186335 657 dbSNP
rs1241621134 659 dbSNP
rs11076213 660 dbSNP
rs1018674838 663 dbSNP
rs961806303 665 dbSNP
rs755989583 668 dbSNP
rs1213452823 679 dbSNP
rs971710613 680 dbSNP
rs937990641 687 dbSNP
rs1316543441 696 dbSNP
rs1204068000 701 dbSNP
rs1055252891 702 dbSNP
rs893873425 704 dbSNP
rs1444164381 708 dbSNP
rs1249129529 710 dbSNP
rs920281968 716 dbSNP
rs1328382191 726 dbSNP
rs1428096261 730 dbSNP
rs1011037277 749 dbSNP
rs930544720 753 dbSNP
rs1164309826 754 dbSNP
rs1444544869 755 dbSNP
rs980747767 761 dbSNP
rs1383994408 768 dbSNP
rs1179284494 786 dbSNP
rs1179343798 788 dbSNP
rs1251619834 789 dbSNP
rs926535358 789 dbSNP
rs939174084 790 dbSNP
rs1056714144 798 dbSNP
rs1030308782 804 dbSNP
rs140020869 807 dbSNP
rs544089085 809 dbSNP
rs945485607 812 dbSNP
rs1017363162 813 dbSNP
rs963423096 816 dbSNP
rs1352995191 817 dbSNP
rs1031780988 818 dbSNP
rs1298534566 819 dbSNP
rs1366636778 822 dbSNP
rs1043702718 823 dbSNP
rs1303829522 825 dbSNP
rs1305514640 829 dbSNP
rs1348030479 834 dbSNP
rs1161847450 839 dbSNP
rs1227077973 841 dbSNP
rs919062531 844 dbSNP
rs929109282 860 dbSNP
rs982047158 861 dbSNP
rs779768648 862 dbSNP
rs1050779 866 dbSNP
rs530910320 886 dbSNP
rs1049972004 887 dbSNP
rs891392322 888 dbSNP
rs1263204101 891 dbSNP
rs1008369345 894 dbSNP
rs1204698852 899 dbSNP
rs1015799112 905 dbSNP
rs1283278078 906 dbSNP
rs1317458484 906 dbSNP
rs1252327593 907 dbSNP
rs961772283 914 dbSNP
rs1347581244 926 dbSNP
rs993286845 926 dbSNP
rs1284220462 928 dbSNP
rs1027317186 938 dbSNP
rs552110620 940 dbSNP
rs1365500380 941 dbSNP
rs1290728512 951 dbSNP
rs980862763 954 dbSNP
rs41388349 960 dbSNP
rs1455048319 967 dbSNP
rs149584196 968 dbSNP
rs998308326 973 dbSNP
rs1199645947 975 dbSNP
rs991985131 976 dbSNP
rs913774037 979 dbSNP
rs890002499 984 dbSNP
rs1007230193 986 dbSNP
rs1187822490 998 dbSNP
rs546868183 1002 dbSNP
rs768512372 1004 dbSNP
rs1017667230 1005 dbSNP
rs945454629 1010 dbSNP
rs1206560347 1019 dbSNP
rs1122306 1023 dbSNP
rs994614998 1025 dbSNP
rs1026048469 1033 dbSNP
rs1310726802 1034 dbSNP
rs950568276 1042 dbSNP
rs1459651588 1043 dbSNP
rs771014956 1050 dbSNP
rs927910526 1051 dbSNP
rs1455086335 1057 dbSNP
rs1407216002 1058 dbSNP
rs1176179049 1061 dbSNP
rs1371669766 1071 dbSNP
rs932646219 1073 dbSNP
rs536014148 1074 dbSNP
rs891367295 1076 dbSNP
rs748199428 1078 dbSNP
rs1246901151 1080 dbSNP
rs1428639730 1080 dbSNP
rs1008919972 1085 dbSNP
rs915198372 1087 dbSNP
rs772099003 1088 dbSNP
rs1243518553 1091 dbSNP
rs1311528715 1099 dbSNP
rs1319509162 1104 dbSNP
rs1482383814 1105 dbSNP
rs773426113 1117 dbSNP
rs557294607 1118 dbSNP
rs1228460231 1130 dbSNP
rs568889780 1132 dbSNP
rs1248731528 1136 dbSNP
rs1384257095 1141 dbSNP
rs1336479415 1142 dbSNP
rs1394694415 1143 dbSNP
rs1399576496 1150 dbSNP
rs1299473408 1164 dbSNP
rs897363532 1171 dbSNP
rs539550012 1172 dbSNP
rs1166239689 1174 dbSNP
rs1469305248 1175 dbSNP
rs557928662 1176 dbSNP
rs1385835551 1178 dbSNP
rs1240487640 1183 dbSNP
rs760827342 1184 dbSNP
rs1421783082 1185 dbSNP
rs572875140 1195 dbSNP
rs764925239 1199 dbSNP
rs1482860720 1202 dbSNP
rs1272554214 1206 dbSNP
rs1001864687 1216 dbSNP
rs1360755252 1218 dbSNP
rs1187372819 1225 dbSNP
rs1033787075 1229 dbSNP
rs1308163397 1229 dbSNP
rs960651590 1230 dbSNP
rs1305612276 1231 dbSNP
rs890064402 1243 dbSNP
rs1007526602 1245 dbSNP
rs1365684099 1246 dbSNP
rs1162545595 1252 dbSNP
rs1471772850 1254 dbSNP
rs1365268978 1261 dbSNP
rs1038602621 1266 dbSNP
rs898852892 1267 dbSNP
rs994500436 1268 dbSNP
rs950412921 1272 dbSNP
rs1289279851 1274 dbSNP
rs1394860950 1277 dbSNP
rs1050792 1280 dbSNP
rs1456704150 1282 dbSNP
rs1208501702 1290 dbSNP
rs992517075 1293 dbSNP
rs564141079 1294 dbSNP
rs1349475890 1298 dbSNP
rs1286023406 1299 dbSNP
rs1430863576 1306 dbSNP
rs555663405 1317 dbSNP
rs41523344 1322 dbSNP
rs879055432 1324 dbSNP
rs1322324119 1325 dbSNP
rs776901067 1330 dbSNP
rs759922674 1331 dbSNP
rs1158896231 1341 dbSNP
rs1456552276 1345 dbSNP
rs932759411 1346 dbSNP
rs765685450 1350 dbSNP
rs753211634 1355 dbSNP
rs944296040 1356 dbSNP
rs924032200 1361 dbSNP
rs1037253183 1367 dbSNP
rs934056048 1372 dbSNP
rs1263112679 1373 dbSNP
rs1216622656 1375 dbSNP
rs1208679529 1378 dbSNP
rs897429043 1382 dbSNP
rs573872592 1383 dbSNP
rs1048622810 1385 dbSNP
rs1345354069 1387 dbSNP
rs544344866 1391 dbSNP
rs866185153 1392 dbSNP
rs1039062941 1393 dbSNP
rs1156549963 1394 dbSNP
rs562550928 1399 dbSNP
rs1033340364 1401 dbSNP
rs1434314987 1404 dbSNP
rs1386092298 1410 dbSNP
rs1178335556 1412 dbSNP
rs898739955 1421 dbSNP
rs1424778337 1430 dbSNP
rs1170875179 1432 dbSNP
rs1476406757 1439 dbSNP
rs533193488 1450 dbSNP
rs1047388240 1451 dbSNP
rs1013205636 1452 dbSNP
rs1020806718 1453 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions WI26
Disease 4324.0
Location of target site 3'UTR
Tools used in this research MicroCosm , TargetScan
Original Description (Extracted from the article) ... "Among the 17 others miRNA-mRNA pairs that were evaluated (Figure 4E-H and Figure 5) ...

- Garbacki N; Di Valentin E; Huynh-Thu VA; et al., 2011, PloS one.

Article - Garbacki N; Di Valentin E; Huynh-Thu VA; et al.
- PloS one, 2011
BACKGROUND: miRNAs are now recognized as key regulator elements in gene expression. Although they have been associated with a number of human diseases, their implication in acute and chronic asthma and their association with lung remodelling have never been thoroughly investigated. METHODOLOGY/PRINCIPAL FINDINGS: In order to establish a miRNAs expression profile in lung tissue, mice were sensitized and challenged with ovalbumin mimicking acute, intermediate and chronic human asthma. Levels of lung miRNAs were profiled by microarray and in silico analyses were performed to identify potential mRNA targets and to point out signalling pathways and biological processes regulated by miRNA-dependent mechanisms. Fifty-eight, 66 and 75 miRNAs were found to be significantly modulated at short-, intermediate- and long-term challenge, respectively. Inverse correlation with the expression of potential mRNA targets identified mmu-miR-146b, -223, -29b, -29c, -483, -574-5p, -672 and -690 as the best candidates for an active implication in asthma pathogenesis. A functional validation assay was performed by cotransfecting in human lung fibroblasts (WI26) synthetic miRNAs and engineered expression constructs containing the coding sequence of luciferase upstream of the 3'UTR of various potential mRNA targets. The bioinformatics analysis identified miRNA-linked regulation of several signalling pathways, as matrix metalloproteinases, inflammatory response and TGF-beta signalling, and biological processes, including apoptosis and inflammation. CONCLUSIONS/SIGNIFICANCE: This study highlights that specific miRNAs are likely to be involved in asthma disease and could represent a valuable resource both for biological makers identification and for unveiling mechanisms underlying the pathogenesis of asthma.
LinkOut: [PMID: 21305051]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21032 Prostate cancer -0.379 2.1e-4 -0.294 3.5e-3 83 Click to see details
GSE14794 Lymphoblastoid cells -0.238 1.2e-2 -0.313 1.3e-3 90 Click to see details
GSE28544 Breast cancer -0.441 1.5e-2 -0.508 5.6e-3 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.45 2.3e-2 -0.424 3.1e-2 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.399 2.4e-2 -0.372 3.4e-2 25 Click to see details
GSE19536 Breast cancer -0.192 2.8e-2 -0.218 1.5e-2 100 Click to see details
GSE19783 ER- ER- breast cancer -0.206 3.4e-2 -0.210 3.2e-2 79 Click to see details
GSE19783 ER+ ER+ breast cancer -0.352 6.4e-2 -0.353 6.3e-2 20 Click to see details
GSE42095 Differentiated embryonic stem cells -0.295 8.6e-2 -0.182 2.0e-1 23 Click to see details
GSE27834 Pluripotent stem cells 0.347 9.4e-2 0.497 2.5e-2 16 Click to see details
GSE28260 Renal cortex and medulla 0.368 1.1e-1 0.341 1.3e-1 13 Click to see details
GSE17306 Multiple myeloma 0.165 1.3e-1 0.130 1.9e-1 49 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.386 2.2e-1 0.771 3.6e-2 6 Click to see details
GSE38226 Liver fibrosis -0.126 2.9e-1 -0.138 2.8e-1 21 Click to see details
GSE21687 Ependynoma primary tumors -0.058 3.2e-1 -0.064 3.1e-1 64 Click to see details
GSE26953 Aortic valvular endothelial cells -0.087 3.4e-1 -0.055 4.0e-1 24 Click to see details
GSE19350 CNS germ cell tumors 0.098 3.8e-1 0.140 3.3e-1 12 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.057 3.9e-1 -0.127 2.7e-1 25 Click to see details
GSE32688 Pancreatic cancer -0.037 4.2e-1 -0.069 3.5e-1 32 Click to see details
GSE17498 Multiple myeloma -0.011 4.7e-1 -0.151 1.8e-1 40 Click to see details
GSE17498 Multiple myeloma -0.011 4.7e-1 -0.151 1.8e-1 40 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
STAD 0.691 0 0.668 0 32 Click to see details
ESCA 0.89 0 0.836 0 11 Click to see details
KIRP -0.47 0 -0.442 0.01 32 Click to see details
PRAD 0.31 0.01 0.031 0.42 50 Click to see details
THCA -0.275 0.02 -0.297 0.01 59 Click to see details
BLCA 0.435 0.04 0.348 0.08 18 Click to see details
KIRC -0.206 0.05 -0.126 0.15 68 Click to see details
HNSC 0.261 0.05 0.249 0.06 42 Click to see details
PCPG -0.988 0.05 -1.000 0.5 3 Click to see details
KICH -0.335 0.05 -0.117 0.29 25 Click to see details
UCEC -0.37 0.06 -0.305 0.1 19 Click to see details
PAAD -0.705 0.15 -0.400 0.3 4 Click to see details
LUAD 0.277 0.19 0.119 0.36 12 Click to see details
LIHC 0.096 0.26 0.041 0.39 49 Click to see details
COAD -0.257 0.27 -0.167 0.35 8 Click to see details
BRCA -0.064 0.28 0.011 0.46 84 Click to see details
LUSC 0.092 0.29 0.041 0.4 38 Click to see details
CHOL -0.193 0.31 -0.167 0.33 9 Click to see details
CESC 0.516 0.33 0.500 0.33 3 Click to see details
CESC 0.516 0.33 0.500 0.33 3 Click to see details
CESC 0.516 0.33 0.500 0.33 3 Click to see details
248 hsa-miR-29b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000095 TGFB3 transforming growth factor beta 3 2 1
MIRT000096 HDAC4 histone deacetylase 4 4 4
MIRT000097 CTNNBIP1 catenin beta interacting protein 1 4 4
MIRT000098 COL5A3 collagen type V alpha 3 chain 2 2
MIRT000099 COL4A2 collagen type IV alpha 2 chain 2 2
MIRT000100 COL1A1 collagen type I alpha 1 chain 8 8
MIRT000101 ACVR2A activin A receptor type 2A 1 1
MIRT000445 SP1 Sp1 transcription factor 5 6
MIRT000684 CDK6 cyclin dependent kinase 6 6 5
MIRT000930 BACE1 beta-secretase 1 3 1
MIRT002310 SFPQ splicing factor proline and glutamine rich 3 1
MIRT002316 DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 3 1
MIRT003026 DNMT3B DNA methyltransferase 3 beta 4 7
MIRT003029 DNMT3A DNA methyltransferase 3 alpha 5 9
MIRT003287 MCL1 MCL1, BCL2 family apoptosis regulator 7 20
MIRT003290 BCL2 BCL2, apoptosis regulator 4 3
MIRT003661 DNMT1 DNA methyltransferase 1 4 2
MIRT003736 S100B S100 calcium binding protein B 3 1
MIRT003813 VEGFA vascular endothelial growth factor A 9 9
MIRT004308 ESR1 estrogen receptor 1 2 1
MIRT004312 NCOA3 nuclear receptor coactivator 3 2 1
MIRT004419 TET1 tet methylcytosine dioxygenase 1 4 2
MIRT004510 TCL1A T-cell leukemia/lymphoma 1A 5 4
MIRT005381 Mmp15 matrix metallopeptidase 15 3 1
MIRT005383 MMP15 matrix metallopeptidase 15 2 1
MIRT005385 MMP24 matrix metallopeptidase 24 4 2
MIRT005387 Mmp24 matrix metallopeptidase 24 2 1
MIRT005486 GRN granulin precursor 4 1
MIRT005522 FGG fibrinogen gamma chain 2 1
MIRT005533 FGA fibrinogen alpha chain 2 1
MIRT005534 FGB fibrinogen beta chain 2 1
MIRT005567 COL3A1 collagen type III alpha 1 chain 5 4
MIRT005568 COL4A1 collagen type IV alpha 1 chain 7 9
MIRT005570 MMP2 matrix metallopeptidase 2 5 8
MIRT005614 BBC3 BCL2 binding component 3 2 2
MIRT005667 ADAM12 ADAM metallopeptidase domain 12 5 3
MIRT005669 NID1 nidogen 1 4 1
MIRT006054 HMGA2 high mobility group AT-hook 2 3 1
MIRT006058 TGFB2 transforming growth factor beta 2 3 2
MIRT006059 TGFB1 transforming growth factor beta 1 2 1
MIRT006060 BMP1 bone morphogenetic protein 1 3 2
MIRT006098 PTEN phosphatase and tensin homolog 7 3
MIRT006251 NASP nuclear autoantigenic sperm protein 2 1
MIRT006486 PPP1R13B protein phosphatase 1 regulatory subunit 13B 2 1
MIRT006488 CDC42 cell division cycle 42 4 2
MIRT006753 GSK3B glycogen synthase kinase 3 beta 1 1
MIRT006815 PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma 3 1
MIRT006915 NKIRAS2 NFKB inhibitor interacting Ras like 2 5 3
MIRT007011 RAX retina and anterior neural fold homeobox 2 1
MIRT007033 TBX21 T-box 21 1 1
MIRT007034 IFNG interferon gamma 1 1
MIRT007102 DUSP2 dual specificity phosphatase 2 3 3
MIRT007254 FOS Fos proto-oncogene, AP-1 transcription factor subunit 3 3
MIRT027237 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 2 2
MIRT027238 IMPDH1 inosine monophosphate dehydrogenase 1 2 2
MIRT027239 MYCN MYCN proto-oncogene, bHLH transcription factor 3 3
MIRT048359 SCAF8 SR-related CTD associated factor 8 1 1
MIRT048360 CLDN1 claudin 1 1 1
MIRT048361 MRPS35 mitochondrial ribosomal protein S35 1 1
MIRT048362 RSL24D1 ribosomal L24 domain containing 1 1 1
MIRT048363 LRP10 LDL receptor related protein 10 1 1
MIRT048364 HP1BP3 heterochromatin protein 1 binding protein 3 1 1
MIRT048365 B4GALT5 beta-1,4-galactosyltransferase 5 1 1
MIRT048366 KIAA1671 KIAA1671 1 1
MIRT048367 NNT nicotinamide nucleotide transhydrogenase 1 1
MIRT048368 IFIH1 interferon induced with helicase C domain 1 1 1
MIRT048369 TPT1 tumor protein, translationally-controlled 1 1 1
MIRT048370 RUNDC3B RUN domain containing 3B 1 1
MIRT048371 CECR2 CECR2, histone acetyl-lysine reader 1 1
MIRT048372 TPD52L2 tumor protein D52 like 2 1 1
MIRT048373 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 1 1
MIRT048374 CIT citron rho-interacting serine/threonine kinase 1 1
MIRT048375 GNB2L1 receptor for activated C kinase 1 1 1
MIRT048376 SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 1 1
MIRT048377 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 1 1
MIRT048378 PIGN phosphatidylinositol glycan anchor biosynthesis class N 1 1
MIRT048379 RPS4X ribosomal protein S4, X-linked 1 1
MIRT048380 CCSAP centriole, cilia and spindle associated protein 1 1
MIRT048381 CALU calumenin 1 1
MIRT048382 NREP neuronal regeneration related protein 1 1
MIRT048383 MKI67 marker of proliferation Ki-67 1 1
MIRT053293 TDG thymine DNA glycosylase 5 5
MIRT053581 CCND2 cyclin D2 5 3
MIRT053738 COL4A5 collagen type IV alpha 5 chain 1 1
MIRT053739 COL7A1 collagen type VII alpha 1 chain 1 1
MIRT053740 COL15A1 collagen type XV alpha 1 chain 1 1
MIRT053741 COL2A1 collagen type II alpha 1 chain 1 1
MIRT053742 COL4A6 collagen type IV alpha 6 chain 1 1
MIRT053743 CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 1 1
MIRT053744 SOX12 SRY-box 12 1 1
MIRT053745 MAP2K6 mitogen-activated protein kinase kinase 6 1 1
MIRT053746 TGIF2 TGFB induced factor homeobox 2 1 1
MIRT053747 SERPINH1 serpin family H member 1 2 2
MIRT053748 NOTCH2 notch 2 4 1
MIRT053749 PPARD peroxisome proliferator activated receptor delta 1 1
MIRT054045 SNAI3 snail family transcriptional repressor 3 2 1
MIRT054192 AKT2 AKT serine/threonine kinase 2 4 2
MIRT054574 PER1 period circadian clock 1 3 1
MIRT060983 LAMC1 laminin subunit gamma 1 3 1
MIRT061662 BTG2 BTG anti-proliferation factor 2 2 4
MIRT067385 TMTC3 transmembrane and tetratricopeptide repeat containing 3 2 4
MIRT079942 RNF138 ring finger protein 138 2 2
MIRT080798 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 4
MIRT081893 KCTD15 potassium channel tetramerization domain containing 15 2 8
MIRT082515 CALM3 calmodulin 3 2 2
MIRT085293 CCNT2 cyclin T2 2 6
MIRT102856 INSIG1 insulin induced gene 1 2 2
MIRT207249 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT207755 VHL von Hippel-Lindau tumor suppressor 2 4
MIRT210969 TET2 tet methylcytosine dioxygenase 2 1 1
MIRT211650 ABCE1 ATP binding cassette subfamily E member 1 2 2
MIRT213230 REST RE1 silencing transcription factor 2 10
MIRT225103 GOLGA7 golgin A7 2 2
MIRT250481 MAZ MYC associated zinc finger protein 2 2
MIRT264266 FAM102B family with sequence similarity 102 member B 2 2
MIRT267090 ZFP91 ZFP91 zinc finger protein 2 2
MIRT303363 MXD1 MAX dimerization protein 1 2 1
MIRT316344 ULBP2 UL16 binding protein 2 2 2
MIRT401476 AIM1 crystallin beta-gamma domain containing 1 2 1
MIRT437369 LAMC2 laminin subunit gamma 2 3 1
MIRT437372 ITGA6 integrin subunit alpha 6 3 2
MIRT437552 COL5A2 collagen type V alpha 2 chain 1 1
MIRT437553 COL10A1 collagen type X alpha 1 chain 1 1
MIRT437554 SPARC secreted protein acidic and cysteine rich 1 1
MIRT437555 FBN1 fibrillin 1 1 1
MIRT437556 LOX lysyl oxidase 2 2
MIRT437557 PDGFRB platelet derived growth factor receptor beta 2 2
MIRT437710 PHACTR2 phosphatase and actin regulator 2 2 1
MIRT437713 TUBB2A tubulin beta 2A class IIa 2 1
MIRT437716 EMP1 epithelial membrane protein 1 2 1
MIRT437719 SNX24 sorting nexin 24 2 1
MIRT437722 AMFR autocrine motility factor receptor 2 1
MIRT437725 RIOK3 RIO kinase 3 2 1
MIRT437728 WDR26 WD repeat domain 26 4 3
MIRT437731 DSC2 desmocollin 2 2 1
MIRT437870 IL32 interleukin 32 1 1
MIRT438911 GATA3 GATA binding protein 3 2 1
MIRT438912 PDGFRA platelet derived growth factor receptor alpha 2 1
MIRT438913 PDGFC platelet derived growth factor C 2 1
MIRT438914 PDGFB platelet derived growth factor subunit B 2 1
MIRT438915 PDGFA platelet derived growth factor subunit A 2 1
MIRT438916 MMP9 matrix metallopeptidase 9 2 1
MIRT438917 LOXL4 lysyl oxidase like 4 2 1
MIRT438918 LOXL2 lysyl oxidase like 2 2 1
MIRT438919 ITGB1 integrin subunit beta 1 2 1
MIRT438920 ANGPTL4 angiopoietin like 4 2 1
MIRT454812 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT456827 MORF4L2 mortality factor 4 like 2 2 8
MIRT462151 RPL22 ribosomal protein L22 2 2
MIRT465314 TRAM2 translocation associated membrane protein 2 2 2
MIRT467808 SLC2A14 solute carrier family 2 member 14 2 2
MIRT467829 SLC29A2 solute carrier family 29 member 2 2 2
MIRT467971 SLC16A1 solute carrier family 16 member 1 2 4
MIRT468225 SGK1 serum/glucocorticoid regulated kinase 1 2 2
MIRT469448 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT469723 RAB40C RAB40C, member RAS oncogene family 2 2
MIRT469841 R3HDM4 R3H domain containing 4 2 2
MIRT472643 NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit 2 2
MIRT474209 LEPRE1 prolyl 3-hydroxylase 1 1 1
MIRT474576 KLHDC3 kelch domain containing 3 2 2
MIRT475837 HDGF heparin binding growth factor 2 4
MIRT476721 FRK fyn related Src family tyrosine kinase 2 4
MIRT477473 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 2
MIRT478668 CTC1 CST telomere replication complex component 1 2 14
MIRT478710 CSRNP2 cysteine and serine rich nuclear protein 2 2 2
MIRT478985 COMMD2 COMM domain containing 2 2 2
MIRT479826 CCNA2 cyclin A2 2 8
MIRT479901 CCDC117 coiled-coil domain containing 117 2 2
MIRT480066 CAND1 cullin associated and neddylation dissociated 1 2 2
MIRT482012 AMER1 APC membrane recruitment protein 1 2 8
MIRT489024 C1QTNF6 C1q and TNF related 6 5 2
MIRT492513 RAET1L retinoic acid early transcript 1L 2 2
MIRT493825 FSCN1 fascin actin-bundling protein 1 2 2
MIRT495936 SLC7A5P2 solute carrier family 7 member 5 pseudogene 2 2 2
MIRT496358 PPY pancreatic polypeptide 2 2
MIRT496662 TMEM237 transmembrane protein 237 2 2
MIRT497644 GLDN gliomedin 2 2
MIRT501878 MORF4L1 mortality factor 4 like 1 2 8
MIRT502932 CDC42SE1 CDC42 small effector 1 2 4
MIRT506750 LDOC1L retrotransposon Gag like 6 2 6
MIRT507168 GAS2L3 growth arrest specific 2 like 3 2 2
MIRT514918 MDM2 MDM2 proto-oncogene 2 6
MIRT523962 DYNLT1 dynein light chain Tctex-type 1 2 4
MIRT527675 CASP8 caspase 8 2 2
MIRT536936 HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 2 2
MIRT537359 FJX1 four jointed box 1 2 2
MIRT537687 ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 2 2
MIRT538124 DDX6 DEAD-box helicase 6 2 2
MIRT538813 C21orf91 chromosome 21 open reading frame 91 2 2
MIRT546938 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT547104 PLAG1 PLAG1 zinc finger 2 2
MIRT547823 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT548237 FEM1B fem-1 homolog B 2 2
MIRT550036 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT552619 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT556562 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT558857 CDC23 cell division cycle 23 2 2
MIRT565485 SPRTN SprT-like N-terminal domain 2 2
MIRT568205 CBX6 chromobox 6 2 2
MIRT576774 Tmem127 transmembrane protein 127 2 2
MIRT576958 Pigs phosphatidylinositol glycan anchor biosynthesis, class S 2 3
MIRT610003 PIGS phosphatidylinositol glycan anchor biosynthesis class S 2 3
MIRT616511 COX7A2L cytochrome c oxidase subunit 7A2 like 2 2
MIRT640887 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT641350 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT642978 TESPA1 thymocyte expressed, positive selection associated 1 2 2
MIRT643634 YY2 YY2 transcription factor 2 2
MIRT644386 ZNF286A zinc finger protein 286A 2 2
MIRT650749 YAE1D1 Yae1 domain containing 1 2 2
MIRT661585 EPHX2 epoxide hydrolase 2 2 2
MIRT664287 RNMTL1 mitochondrial rRNA methyltransferase 3 2 2
MIRT689393 ZNF850 zinc finger protein 850 2 2
MIRT693815 SEC31A SEC31 homolog A, COPII coat complex component 2 2
MIRT694532 TRIM72 tripartite motif containing 72 2 2
MIRT694628 ZFPM1 zinc finger protein, FOG family member 1 2 2
MIRT695135 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695152 PRY PTPN13-like, Y-linked 2 2
MIRT703640 FBRS fibrosin 2 2
MIRT704551 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT704967 CBX2 chromobox 2 2 2
MIRT705497 ASXL2 additional sex combs like 2, transcriptional regulator 2 2
MIRT707993 OTUD4 OTU deubiquitinase 4 2 2
MIRT708741 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT710621 COLEC10 collectin subfamily member 10 2 2
MIRT713056 IFRD1 interferon related developmental regulator 1 2 2
MIRT715515 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT720770 FAM193A family with sequence similarity 193 member A 2 2
MIRT731925 AQP4 aquaporin 4 3 1
MIRT732673 HMGB1 high mobility group box 1 3 0
MIRT734350 IL6 interleukin 6 1 0
MIRT734351 TP53 tumor protein p53 1 0
MIRT734565 BCL2L11 BCL2 like 11 2 0
MIRT734770 TRIM44 tripartite motif containing 44 2 0
MIRT734771 CCNE1 cyclin E1 2 0
MIRT735260 STAT3 signal transducer and activator of transcription 3 6 1
MIRT735414 HBP1 HMG-box transcription factor 1 3 0
MIRT735537 HIF3A hypoxia inducible factor 3 alpha subunit 3 0
MIRT735639 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 3 0
MIRT735641 AKT3 AKT serine/threonine kinase 3 3 0
MIRT735943 DNM3OS DNM3 opposite strand/antisense RNA 4 0
MIRT737493 SMAD3 SMAD family member 3 1 0
MIRT737577 SNAI1 snail family transcriptional repressor 1 2 0
MIRT755941 SLMAP sarcolemma associated protein 4 1
MIRT755963 ROBO1 roundabout guidance receptor 1 5 1
MIRT755964 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 5 1
MIRT756271 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 3 1
MIRT756364 LIN7A lin-7 homolog A, crumbs cell polarity complex component 2 1
MIRT756474 COL5A1 collagen type V alpha 1 chain 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-29b 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray Pancreatic Cancer MiaPACA-2 cells 19407485 2009 up-regulated
miR-29b 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray Pancreatic Cancer PANC-1 cells 19407485 2009 up-regulated
miR-29b 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) NULL NULL Microarray Pancreatic Cancer MiaPACA-2 cells 19407485 2009 up-regulated
miR-29b 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) NULL NULL Microarray Pancreatic Cancer PANC-1 cells 19407485 2009 up-regulated
miR-29b Trichostatin A (TSA) NULL 444732 Microarray Pancreatic Cancer MiaPACA-2 cells 19407485 2009 up-regulated
miR-29b Trichostatin A (TSA) NULL 444732 Microarray Pancreatic Cancer PANC-1 cells 19407485 2009 up-regulated
miR-29b Glucose NULL 5793 Microarray proximal tubule cell line HK-2 20067797 2010 down-regulated
miR-29b Dihydrotestosterone(DHT) NULL 10635 Microarray prostate cancer 20945501 2011 up-regulated
miR-29b Dihydrotestosterone(DHT) NULL 10635 Quantitative real-time PCR prostate cancer 20945501 2011 up-regulated
miR-29b Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-29b Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
miR-29b Ginsenoside Rh2 NULL 119307 Microarray human glioma cells U251 21372826 2011 up-regulated
miR-29b Testosterone + 1,25-Dihydroxyvitamin D3 approved NULL Microarray prostate cancer 21592394 2011 up-regulated
miR-29b Progesterone approved 5994 Microarray Breast cancer 22330642 2012 down-regulated
miR-29b Progesterone approved 5994 Quantitative real-time PCR Breast cancer 22330642 2012 down-regulated
miR-29b Trastuzumab approved NULL Microarray SKBR3 cells. 22384020 2012 up-regulated
miR-29b Glucocorticoid NULL NULL Quantitative real-time PCR Eosinophilic esophagitis 22815788 2012 up-regulated
miR-29b Glucocorticoid NULL NULL TaqMan low-density array Eosinophilic esophagitis 22815788 2012 up-regulated
miR-29b CCl4 NULL 5943 Quantitative real-time PCR liver 22393047 2012 down-regulated
miR-29b Estrogen NULL NULL Quantitative real-time PCR liver 22393047 2012 up-regulated
miR-29b Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 down-regulated
miR-29b 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 down-regulated
miR-29b Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-29b Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice liver 20145010 2010 down-regulated
miR-29b Benzo(a)pyrene NULL 2336 Microarray Adult male B6C3F1 mice 21569818 2011 up-regulated
miR-29b Cocaine NULL 446220 Next-generation sequencing ventral striatum 21708909 2011 down-regulated
miR-29b Urethane NULL 5641 Quantitative real-time PCR mouse lung 24361357 2014 down-regulated
miR-29b Ethanol NULL 702 Quantitative real-time PCR Cerebellar Granule Neurons cells 24554719 2014 down-regulated
miR-29b Rapamycin approved 5284616 Quantitative real-time PCR HL-1 cells 25062042 2014 up-regualted
miR-29b Estradiol benzoate (EB) NULL NULL Quantitative real-time PCR adult germ cell 22334722 2012 up-regulated
miR-29b Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miR-29b-3p Docosahexaenoic acid NULL 445580 Quantitative real-time PCR Caco-2 cells 24623846 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-29b Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (HepG2, SK-HEP-1)
hsa-miR-29b-3p (1S,10R,12R,14R,15S)-15-hydroxyspiro[13,16-dioxapentacyclo[8.5.1.01,10.03,8.012,14]hexadeca-3,5,7-triene-11,3'-2,4-dioxatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaene]-2,9-dione 388424 NSC683332 resistant
hsa-miR-29b-3p (5Z)-5-[(4-oxothieno[2,3-b]thiochromen-2-yl)methylidene]-2-sulfanylideneimidazolidin-4-one 5468927 NSC679240 resistant
hsa-miR-29b-3p (6aS)-3-[5-[4-(2-diethoxyphosphorylethyl)piperazin-1-yl]pentoxy]-2-methoxy-6a,7,8,9-tetrahydropyrrolo[2,1-c][1,4]benzodiazepin-11-one 25113728 NSC744025 resistant
hsa-miR-29b-3p 1-adamantylmethyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate 391131 NSC689857 resistant
hsa-miR-29b-3p 2-((5-methyl-3-isoxazolyl)amino)-4-((5-methyl-3-isoxazolyl)imino)-1(4h)-naphthalenone 373420 NSC649750 sensitive
hsa-miR-29b-3p 2-(1-adamantyl)ethyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate 403758 NSC719177 resistant
hsa-miR-29b-3p 2-(3-(2-methoxy-4-(4-methylene-5-oxotetrahydro-2-furanyl)phenoxy)propyl)-1h-isoindole-1,3(2h)-dione 381521 NSC668277 resistant
hsa-miR-29b-3p 2-[(dimethylamino)methyl]-3-[(Z)-heptadec-10-enyl]-5-methoxybenzene-1,4-diol;hydrochloride 5387959 NSC630004 resistant
hsa-miR-29b-3p 2-[[(E)-3-(2-chlorophenyl)prop-2-enoyl]amino]-5-iodobenzamide 53329762 NSC748148 resistant
hsa-miR-29b-3p 2-acetylimidazo[4,5-b]pyridin 4 tolyl 3 thiosemicarbazone 135440014 NSC674106 resistant
hsa-miR-29b-3p 2-amino-1-N,9-N-bis[10-[(4-hydroxyphenyl)methyl]-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3-propan-2-yl-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboxamide 16129921 NSC684901 resistant
hsa-miR-29b-3p 2-amino-1-N,9-N-bis[10-[(4-methoxyphenyl)methyl]-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3-propan-2-yl-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-4,6-dimethyl-3-oxophenoxazine-1,9-dicarboxamide 16129907 NSC684908 resistant
hsa-miR-29b-3p 2-amino-9-chloro-3,5-bis(4-chlorophenyl)pyrimido[4,5-c]quinolin-1-one 16126264 NSC741296 resistant
hsa-miR-29b-3p 2,3-bis(4,5-dimethyl-3,6-dioxo-cyclohexa-1,4-dien-1-yl)-5,6-dimethyl-1,4-benzoquinone 394545 NSC698090 sensitive
hsa-miR-29b-3p 3-(4-chlorophenyl)-5-methyl-[1,2]oxazolo[5,4-d]triazin-4-one 399226 NSC709900 resistant
hsa-miR-29b-3p 4-[4-[2,3-bis(hydroxymethyl)pyrrol-1-yl]butanoylamino]-n-[5-[[5-[3-(dimethylamino)propylcarbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-1-methylpyrrole-2-carboxamide 384021 NSC673131 resistant
hsa-miR-29b-3p 5-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1h-pyrazole 49865894 NSC748404 resistant
hsa-miR-29b-3p 5,11-dimethyl-1h-benzo[a]carbazole-1,4(11h)-dione 372651 NSC648148 resistant
hsa-miR-29b-3p Acetic acid;3-[4-(2-hydroxyethyl)piperidin-1-yl]-N-[6-[3-[4-(2-hydroxyethyl)piperidin-1-yl]propanoylamino]-9,10-dioxoanthracen-2-yl]propanamide 374314 NSC651841 resistant
hsa-miR-29b-3p Beacon red 135421797 NSC12455 resistant
hsa-miR-29b-3p Benzoic acid, 3,4,5-trihydroxy-, phenyl ester 333279 NSC333571 resistant
hsa-miR-29b-3p Csa13 24205348 NSC735211 sensitive
hsa-miR-29b-3p Mefloquine hydrochloride 456309 NSC157387 sensitive
hsa-miR-29b-3p Methyl 3-hydroxy-3-[(15R)-15-tetracyclo[6.6.2.02,7.09,14]hexadeca-2,4,6,9,11,13-hexaenyl]propanedithioate 383730 NSC672159 resistant
hsa-miR-29b-3p Methyl 6-[[(3S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-[3-[3,4-dihydroxy-6-methyl-5-(3,4,5-trihydroxyoxan-2-yl)oxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxycarbonyl-8-hydroxy-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropi 385532 NSC676788 sensitive
hsa-miR-29b-3p Naphth[2,3-d]oxazol-9-one, 2-methyl-4-(phenylimino)- 160386 NSC650573 sensitive
hsa-miR-29b-3p NSC148077 NSC148077 resistant
hsa-miR-29b-3p NSC175490 NSC175490 resistant
hsa-miR-29b-3p NSC175493 NSC175493 resistant
hsa-miR-29b-3p NSC85701 NSC85701 resistant
hsa-miR-29b-3p Oxin 1923 NSC2039 approved resistant
hsa-miR-29b-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-29b-3p Etoposide 36462 NSC141540 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-29b-3p Paclitaxel 36314 NSC125973 approved resistant High Breast Cancer cell line (MDA-435)
hsa-miR-29b-3p Paclitaxel 36314 NSC125973 approved sensitive High Breast Cancer cell line (MDA-MB-435, MDA-MB-436, SKBr3, BT-474, MDA-MB-231, MCF7)
hsa-miR-29b-3p Imatinib 5291 NSC743414 approved resistant High Myelogenous Leukemia cell line (MYL)
hsa-miR-29b-3p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7, LY2)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3)
hsa-miR-29b-3p Cyclopamine 442972 NSC734950 resistant Low Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-29b-3p Paclitaxel 36314 NSC125973 approved resistant Low Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-29b-3p Etoposide 36462 NSC141540 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-29b-3p Decitabine 451668 approved sensitive Low Acute Myeloid Leukemia tissue and cell line (Kasumi-1, NB4, FDC-P1-KITmut)
hsa-miR-29b-3p Gemcitabine 60750 NSC613327 approved resistant High Bladder Cancer cell line (RT4, J82,TCCSUP, UM-UC-3,RT112,CUBIII)
hsa-miR-29b-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-29b-3p Gemcitabine 60750 NSC613327 approved sensitive Low Cholangiocarcinoma cell line (HuCCT1, HuH28)
hsa-miR-29b-3p Fluorouracil + Oxaliplatin resistant High Colorectal Cancer tissue
hsa-miR-29b-3p Ethanol 702 NSC85228 approved resistant Low Cerebellum Granule Neuron tissue
hsa-miR-29b-3p Chemotherapy sensitive Low Ovarian Cancer tissue
hsa-miR-29b-3p Paclitaxel 36314 NSC125973 approved sensitive Low Ovarian Cancer cell line (ES2, AMOC2)
hsa-miR-29b-3p Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-29b-3p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-29b-3p Bortezomib 387447 NSC681239 approved sensitive Low Melanoma cell line (RPMI8226)
hsa-miR-29b-3p Carfilzomib 11556711 NSC756640 approved sensitive Low Melanoma cell line (RPMI8226)
hsa-miR-29b-3p Ixazomib 25183872 approved sensitive Low Melanoma cell line (RPMI8226)
hsa-miR-29b-3p Interferon-Gamma sensitive Low Colorectal Cancer cell line (HCT-116, HT-29, LS174T, SW480,SW620, HEK293)
hsa-miR-29b-3p Taxane 9548828 sensitive High Prostate Cancer cell line (PC-3, PR200)
hsa-miR-29b-3p Taxane 9548828 sensitive High Prostate Cancer cell line (PC-3, PR70)
hsa-miR-29b-3p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-29b-3p Platinum 23939 resistant Low Ovarian Cancer tissue
hsa-miR-29b-3p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7, PLC)
hsa-miR-29b-3p Imatinib 5291 NSC743414 approved resistant High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, H1299)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved sensitive High Gallbladder Cancer cell line (GBC-SD, NOZ)
hsa-miR-29b-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-29b-3p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-29b-3p Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-29b-3p Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-29b-3p Paclitaxel 36314 NSC125973 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-29b-3p Gemcitabine 60750 NSC613327 approved resistant High Cholangiocarcinoma cell line (CCLP-1, MzChA-1)
hsa-miR-29b-3p Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (SW480)
hsa-miR-29b-3p Paclitaxel 36314 NSC125973 approved sensitive Low Prostate Cancer cell line (PC-3-R)
hsa-miR-29b-3p Methotrexate 126941 NSC740 approved sensitive Low Osteosarcoma tissue and cell line (MG-63, U-2-OS)
hsa-miR-29b-3p Crizotinib 11626560 NSC749005 approved resistant High Non-Small Cell Lung Cancer cell line (NCI-H2228, DFCI032)
hsa-miR-29b-3p Lorlatinib 71731823 NSC780108 approved resistant High Non-Small Cell Lung Cancer cell line (NCI-H2228, DFCI032)
hsa-miR-29b-3p Doxorubicin 31703 NSC123127 approved sensitive Low Osteosarcoma cell line (MG-63)
hsa-miR-29b-3p Gemcitabine 60750 NSC613327 approved sensitive Low Pancreatic Cancer cell line (PANC-1 cell, BXPC-3)
hsa-miR-29b-3p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7, MCF-7-21)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved sensitive Low Endometrial Cancer cell line (HEC-1-B)
hsa-miR-29b-3p Fluorouracil 3385 NSC19893 approved sensitive High Colorectal Cancer cell line (HT-29)
hsa-miR-29b-3p Oxaliplatin 6857599 NSC266046 approved sensitive Low Colon Cancer cell line (SW480, SW620)
hsa-miR-29b-3p Temozolomide 5394 NSC362856 approved sensitive Low Glioma cell line (LN229, U87MG, U251)
hsa-miR-29b-3p Temozolomide 5394 NSC362856 approved sensitive Low Glioblastoma cell line (U251, U87MG)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-29b-3p Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (HT-29, DLD1)
hsa-miR-29b-3p Bortezomib 387447 NSC681239 approved resistant Low Multiple Myeloma tissue
hsa-miR-29b-3p Palbociclib 5330286 NSC758247 approved sensitive High Breast Cancer cell line (MDA-MB-231, Hs578t, SKBR3, MCF-7)
hsa-miR-29b-3p Temozolomide 5394 NSC362856 approved sensitive Low Glioma tissue
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-29b-3p Fluorouracil 3385 NSC19893 approved resistant Low Colorectal Cancer cell line (HT-29, HCT-116, SW480, SW620, LoVo, SW48, DLD-1, Caco-1, HCT-15)
hsa-miR-29b-3p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7, PLC)
hsa-miR-29b-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (mitochondrial RNA)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-29b-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-29b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-29b-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKVO3ip1)
hsa-miR-29b-3p Paclitaxel 36314 NSC125973 approved resistant cell line (HeyA8)
hsa-miR-29b-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-29b-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-29b-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-29b-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-29b-3p Exemestane 60198 NSC713563 approved resistant cell line (MCF-7)
hsa-miR-29b-3p Testosterone 6013 NSC9700 approved resistant cell line (MCF-7)
hsa-miR-29b-3p Testosterone+Anastrozole resistant cell line (MCF-7)
hsa-miR-29b-3p Testosterone+Letrozole resistant cell line (MCF-7)
hsa-miR-29b-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-29b-3p 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-miR-29b-3p Ethanol+Tamoxifen resistant cell line (LY2)
hsa-miR-29b-3p Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-29b-3p Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-29b-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (HuH28)
hsa-miR-29b-3p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-29b-3p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR4)
hsa-miR-29b-3p Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-29b-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR200)
hsa-miR-29b-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR70)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-29b-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-29b-3p Bortezomib 387447 NSC681239 approved resistant cell line (CCRF-CEM) (100 nM)
hsa-miR-29b-3p Bortezomib 387447 NSC681239 approved sensitive cell line (CCRF-CEM) (200 nM)
hsa-miR-29b-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-29b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (OVCAR3)
hsa-miR-29b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (H23)
hsa-miR-29b-3p Cetuximab sensitive tissue (colorectal carcinoma)

Error report submission