miRTarBase - #MIRT005559


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pre-miRNA Information
pre-miRNA hsa-mir-101-1   
Genomic Coordinates chr1: 65058434 - 65058508
Description Homo sapiens miR-101-1 stem-loop
Comment Reference .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-101-5p
Sequence 11| CAGUUAUCACAGUGCUGAUGCU |32
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1235943983 6 dbSNP
rs746487797 7 dbSNP
rs777575128 8 dbSNP
rs1200170859 21 dbSNP
rs548109012 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ATM   
Synonyms AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
Description ATM serine/threonine kinase
Transcript NM_000051   
Expression
Putative miRNA Targets on ATM
3'UTR of ATM
(miRNA target sites are highlighted)		 
>ATM|NM_000051|3'UTR
   1 TCTTCAGTATATGAATTACCCTTTCATTCAGCCTTTAGAAATTATATTTTAGCCTTTATTTTTAACCTGCCAACATACTT
  81 TAAGTAGGGATTAATATTTAAGTGAACTATTGTGGGTTTTTTTGAATGTTGGTTTTAATACTTGATTTAATCACCACTCA
 161 AAAATGTTTTGATGGTCTTAAGGAACATCTCTGCTTTCACTCTTTAGAAATAATGGTCATTCGGGCTGGGCGCAGCGGCT
 241 CACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGAGCGGATCACAAGGTCAGGAGTTCGAGACCAGCCTGGCCAAGA
 321 GACCAGCCTGGCCAGTATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCGAGCATGGTGGCGGGCACCTGTA
 401 ATCCCAGCTACTCGAGAGGCTGAGGCAGGAGAATCTCTTGAACCTGGGAGGTGAAGGTTGCTGTGGGCCAAAATCATGCC
 481 ATTGCACTCCAGCCTGGGTGACAAGAGCGAAACTCCATCTCAAAAAAAAAAAAAAAAAAACAGAAACGTATTTGGATTTT
 561 TCCTAGTAAGATCACTCAGTGTTACTAAATAATGAAGTTGTTATGGAGAACAAATTTCAAAGACACAGTTAGTGTAGTTA
 641 CTATTTTTTTAAGTGTGTATTAAAACTTCTCATTCTATTCTCTTTATCTTTTAAGCCCTTCTGTACTGTCCATGTATGTT
 721 ATCTTTCTGTGATAACTTCATAGATTGCCTTCTAGTTCATGAATTCTCTTGTCAGATGTATATAATCTCTTTTACCCTAT
 801 CCATTGGGCTTCTTCTTTCAGAAATTGTTTTTCATTTCTAATTATGCATCATTTTTCAGATCTCTGTTTCTTGATGTCAT
 881 TTTTAATGTTTTTTTAATGTTTTTTATGTCACTAATTATTTTAAATGTCTGTACTTGATAGACACTGTAATAGTTCTATT
 961 AAATTTAGTTCCTGCTGTTTATATCTGTTGATTTTTGTATTTGATAGGCTGTTCATCCAGTTTTGTCTTTTTGAAAAGTG
1041 AGTTTATTTTCAGCAAGGCTTTATCTATGGGAATCTTGAGTGTCTGTTTATGTCATATTCCCAGGGCTGTTGCTGCACAC
1121 AAGCCCATTCTTATTTTAATTTCTTGGCTTTAGGGTTTCCATACCTGAAGTGTAGCATAAATACTGATAGGAGATTTCCC
1201 AGGCCAAGGCAAACACACTTCCTCCTCATCTCCTTGTGCTAGTGGGCAGAATATTTGATTGATGCCTTTTTCACTGAGAG
1281 TATAAGCTTCCATGTGTCCCACCTTTATGGCAGGGGTGGAAGGAGGTACATTTAATTCCCACTGCCTGCCTTTGGCAAGC
1361 CCTGGGTTCTTTGCTCCCCATATAGATGTCTAAGCTAAAAGCCGTGGGTTAATGAGACTGGCAAATTGTTCCAGGACAGC
1441 TACAGCATCAGCTCACATATTCACCTCTCTGGTTTTTCATTCCCCTCATTTTTTTCTGAGACAGAGTCTTGCTCTGTCAC
1521 CCAGGCTGGAGTGCAGTGGCATGATCTCAGCTCACTGAAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCC
1601 TCCCGAGTAGCTGGGACTACAGGCGTGTGCCAACACGCCCGGCTAATTTTTTGTATTTTTATTAGAGACGGAGTTTCACC
1681 GTGTTAGCCAGGATGGTCTCGATCGCTTGACCTCGTGATCCACCCTCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGT
1761 GAGCCACCGCGCCCGGCCTCATTCCCCTCATTTTTGACCGTAAGGATTTCCCCTTTCTTGTAAGTTCTGCTATGTATTTA
1841 AAAGAATGTTTTCTACATTTTATCCAGCATTTCTCTGTGTTCTGTTGGAAGGGAAGGGCTTAGGTATCTAGTTTGATACA
1921 TAGGTAGAAGTGGAACATTTCTCTGTCCCCCAGCTGTCATCATATAAGATAAACATCAGATAAAAAGCCACCTGAAAGTA
2001 AAACTACTGACTCGTGTATTAGTGAGTATAATCTCTTCTCCATCCTTAGGAAAATGTTCATCCCAGCTGCGGAGATTAAC
2081 AAATGGGTGATTGAGCTTTCTCCTCGTATTTGGACCTTGAAGGTTATATAAATTTTTTTCTTATGAAGAGTTGGCATTTC
2161 TTTTTATTGCCAATGGCAGGCACTCATTCATATTTGATCTCCTCACCTTCCCCTCCCCTAAAACCAATCTCCAGAACTTT
2241 TTGGACTATAAATTTCTTGGTTTGACTTCTGGAGAACTGTTCAGAATATTACTTTGCATTTCAAATTACAAACTTACCTT
2321 GGTGTATCTTTTTCTTACAAGCTGCCTAAATGAATATTTGGTATATATTGGTAGTTTTATTACTATAGTAAATCAAGGAA
2401 ATGCAGTAAACTTAAAATGTCTTTAAGAAAGCCCTGAAATCTTCATGGGTGAAATTAGAAATTATCAACTAGATAATAGT
2481 ATAGATAAATGAATTTGTAGCTAATTCTTGCTAGTTGTTGCATCCAGAGAGCTTTGAATAACATCATTAATCTACTCTTT
2561 AGCCTTGCATGGTATGCTATGAGGCTCCTGTTCTGTTCAAGTATTCTAATCAATGGCTTTGAAAAGTTTATCAAATTTAC
2641 ATACAGATCACAAGCCTAGGAGAAATAACTAATTCACAGATGACAGAATTAAGATTATAAAAGATTTTTTTTTTGTAATT
2721 TTAGTAGAGACAGGGTTGCCATTGTATTCCAGCCTTGGCGACAGAGCAAGACTCTGCCTCAAAAAAAAAAAAAAAAAGGT
2801 TTTGGCAAGCTGGAACTCTTTCTGCAAATGACTAAGATAGAAAACTGCCAAGGACAAATGAGGAGTAGTTAGATTTTGAA
2881 AATATTAATCATAGAATAGTTGTTGTATGCTAAGTCACTGACCCATATTATGTACAGCATTTCTGATCTTTACTTTGCAA
2961 GATTAGTGATACTATCCCAATACACTGCTGGAGAAATCAGAATTTGGAGAAATAAGTTGTCCAAGGCAAGAAGATAGTAA
3041 ATTATAAGTACAAGTGTAATATGGACAGTATCTAACTTGAAAAGATTTCAGGCGAAAAGAATCTGGGGTTTGCCAGTCAG
3121 TTGCTCAAAAGGTCAATGAAAACCAAATAGTGAAGCTATCAGAGAAGCTAATAAATTATAGACTGCTTGAACAGTTGTGT
3201 CCAGATTAAGGGAGATAATAGCTTTCCCACCCTACTTTGTGCAGGTCATACCTCCCCAAAGTGTTTACCTAATCAGTAGG
3281 TTCACAAACTCTTGGTCATTATAGTATATGCCTAAAATGTATGCACTTAGGAATGCTAAAAATTTAAATATGGTCTAAAG
3361 CAAATAAAAGCAAAGAGGAAAAACTTTGGACAGCGTAAAGACTAGAATAGTCTTTTAAAAAGAAAGCCAGTATATTGGTT
3441 TGAAATATAGAGATGTGTCCCAATTTCAAGTATTTTAATTGCACCTTAATGAAATTATCTATTTTCTATAGATTTTAGTA
3521 CTATTGAATGTATTACTTTACTGTTACCTGAATTTATTATAAAGTGTTTTTGAATAAATAATTCTAAAAGC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucGUAGUCGUGACACUAUUGAc 5'
            :|||  : ||||||||||| 
Target 5' gtTATC-TTTCTGTGATAACTt 3'
 718 - 738 163.00 -16.00
2 
miRNA  3' ucGUAGUCGUGACACUAUUGac 5'
            :||||  |||  |||||:  
Target 5' atTATCA--ACT-AGATAATag 3'
 2461 - 2479 119.00 -5.70
3 
miRNA  3' ucGUAGUCGUGACACUAU---UGAc 5'
            ::|| |:||| |||||   ||| 
Target 5' aaTGTCTGTACT-TGATAGACACTg 3'
 924 - 947 119.00 -13.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1001599 1 ClinVar
383897 2 ClinVar
630750 9 ClinVar
983282 9 ClinVar
923314 14 ClinVar
490409 17 ClinVar
627906 18 ClinVar
629158 20 ClinVar
921042 21 ClinVar
302255 30 ClinVar
302256 45 ClinVar
302257 223 ClinVar
877882 224 ClinVar
302258 237 ClinVar
877883 239 ClinVar
877884 245 ClinVar
878045 307 ClinVar
302259 372 ClinVar
878046 510 ClinVar
302260 521 ClinVar
302261 522 ClinVar
302262 522 ClinVar
878047 535 ClinVar
878048 538 ClinVar
302263 540 ClinVar
302264 541 ClinVar
878049 541 ClinVar
302265 549 ClinVar
302266 552 ClinVar
879508 606 ClinVar
879509 628 ClinVar
302267 685 ClinVar
879510 691 ClinVar
879511 704 ClinVar
879512 713 ClinVar
879513 780 ClinVar
879873 796 ClinVar
302268 889 ClinVar
879874 1205 ClinVar
302269 1273 ClinVar
879875 1408 ClinVar
302270 1428 ClinVar
879876 1432 ClinVar
879877 1521 ClinVar
302271 1572 ClinVar
302272 1605 ClinVar
302273 1641 ClinVar
877936 1642 ClinVar
302274 1671 ClinVar
877937 1769 ClinVar
877938 1800 ClinVar
302275 1883 ClinVar
302276 1960 ClinVar
878101 1975 ClinVar
302277 2081 ClinVar
878102 2154 ClinVar
302278 2200 ClinVar
302279 2221 ClinVar
302280 2225 ClinVar
878103 2363 ClinVar
302281 2480 ClinVar
302282 2540 ClinVar
302283 2564 ClinVar
302284 2608 ClinVar
302285 2705 ClinVar
879557 2757 ClinVar
302286 2779 ClinVar
879558 2781 ClinVar
879559 2825 ClinVar
302287 2866 ClinVar
302288 2867 ClinVar
879560 2927 ClinVar
302289 2936 ClinVar
302290 2958 ClinVar
302291 3023 ClinVar
302292 3073 ClinVar
302293 3092 ClinVar
302294 3094 ClinVar
302295 3137 ClinVar
302296 3199 ClinVar
877110 3205 ClinVar
302297 3326 ClinVar
302298 3355 ClinVar
877111 3387 ClinVar
302299 3394 ClinVar
877112 3414 ClinVar
877113 3580 ClinVar
COSM6045692 1 COSMIC
COSM8852774 1 COSMIC
COSN30161219 85 COSMIC
COSN30114880 105 COSMIC
COSN31581000 180 COSMIC
COSN20651445 192 COSMIC
COSN28114636 574 COSMIC
COSN20629658 654 COSMIC
COSN5893961 1162 COSMIC
COSN5893962 1425 COSMIC
COSN28835021 1537 COSMIC
COSN25116401 1944 COSMIC
COSN31529070 2161 COSMIC
COSN22498805 2171 COSMIC
COSN30166994 2199 COSMIC
COSN31606613 2257 COSMIC
COSN4696212 2266 COSMIC
COSN23120630 2327 COSMIC
COSN31481046 2395 COSMIC
COSN10077511 2457 COSMIC
COSN25591918 2826 COSMIC
COSN8730826 2896 COSMIC
COSN22457393 2969 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs757922166 2 dbSNP
rs1217692872 7 dbSNP
rs775359713 7 dbSNP
rs1391467785 10 dbSNP
rs779766044 13 dbSNP
rs1296955906 14 dbSNP
rs1362987304 17 dbSNP
rs746451875 18 dbSNP
rs1293027230 19 dbSNP
rs765917174 19 dbSNP
rs1338371572 20 dbSNP
rs768241804 21 dbSNP
rs1006554443 22 dbSNP
rs1247328981 27 dbSNP
rs3218711 30 dbSNP
rs748058019 32 dbSNP
rs769783429 33 dbSNP
rs1165716504 35 dbSNP
rs55900855 45 dbSNP
rs375136432 46 dbSNP
rs958593856 48 dbSNP
rs1001404454 56 dbSNP
rs557294551 60 dbSNP
rs575824754 70 dbSNP
rs1172558745 71 dbSNP
rs1475585022 72 dbSNP
rs1246087713 76 dbSNP
rs1196722258 81 dbSNP
rs1453231021 88 dbSNP
rs1253149900 91 dbSNP
rs546066915 103 dbSNP
rs1035829637 107 dbSNP
rs992458940 110 dbSNP
rs1216708538 113 dbSNP
rs1354314806 115 dbSNP
rs557873808 118 dbSNP
rs1226579536 122 dbSNP
rs573000957 124 dbSNP
rs768216554 133 dbSNP
rs1373810646 153 dbSNP
rs1289103193 162 dbSNP
rs1447463654 167 dbSNP
rs1446042533 170 dbSNP
rs540238805 173 dbSNP
rs1410717119 176 dbSNP
rs1260686510 190 dbSNP
rs959820109 191 dbSNP
rs1170581526 196 dbSNP
rs988427500 201 dbSNP
rs147355837 206 dbSNP
rs1188204774 208 dbSNP
rs773042897 209 dbSNP
rs1369746588 210 dbSNP
rs912906325 211 dbSNP
rs1300590185 218 dbSNP
rs760852487 223 dbSNP
rs536067082 224 dbSNP
rs1409381017 225 dbSNP
rs1217828475 226 dbSNP
rs1421992999 228 dbSNP
rs761745363 232 dbSNP
rs373104386 233 dbSNP
rs1415683734 234 dbSNP
rs753965490 236 dbSNP
rs3092834 237 dbSNP
rs185904823 238 dbSNP
rs1299947741 240 dbSNP
rs1443277991 241 dbSNP
rs1244189912 244 dbSNP
rs1280155397 245 dbSNP
rs986676453 248 dbSNP
rs1415905535 249 dbSNP
rs910824299 252 dbSNP
rs1376021171 254 dbSNP
rs1437712869 257 dbSNP
rs1381673802 263 dbSNP
rs944900966 272 dbSNP
rs190023130 273 dbSNP
rs1235318113 275 dbSNP
rs897821155 277 dbSNP
rs929413948 279 dbSNP
rs1486829354 281 dbSNP
rs1352686819 282 dbSNP
rs1216586961 283 dbSNP
rs999762766 288 dbSNP
rs867513306 289 dbSNP
rs751145106 302 dbSNP
rs888303888 302 dbSNP
rs1257872379 303 dbSNP
rs530766946 310 dbSNP
rs1416427533 312 dbSNP
rs1440290853 324 dbSNP
rs1038009428 328 dbSNP
rs905804487 340 dbSNP
rs1346887400 351 dbSNP
rs1159200626 352 dbSNP
rs1005395388 367 dbSNP
rs1034560538 369 dbSNP
rs3092835 372 dbSNP
rs1014120290 379 dbSNP
rs1023966265 390 dbSNP
rs967000350 391 dbSNP
rs977604830 398 dbSNP
rs1032776099 400 dbSNP
rs1137918 402 dbSNP
rs1193391254 408 dbSNP
rs1487597483 414 dbSNP
rs1387149096 415 dbSNP
rs1262958216 421 dbSNP
rs1216620155 428 dbSNP
rs1321160148 430 dbSNP
rs1287771501 434 dbSNP
rs1157365479 437 dbSNP
rs1356319930 444 dbSNP
rs959747024 449 dbSNP
rs1397835512 458 dbSNP
rs1380123427 463 dbSNP
rs1435766763 468 dbSNP
rs540321921 477 dbSNP
rs1174631245 484 dbSNP
rs1009942418 485 dbSNP
rs1289326133 491 dbSNP
rs1435169816 498 dbSNP
rs1347661707 499 dbSNP
rs1019882319 503 dbSNP
rs1400356491 508 dbSNP
rs1395604677 509 dbSNP
rs1329700897 510 dbSNP
rs750207793 513 dbSNP
rs1264524736 515 dbSNP
rs570607598 516 dbSNP
rs1488425801 520 dbSNP
rs886047615 521 dbSNP
rs1335728093 522 dbSNP
rs1396541822 522 dbSNP
rs369583811 522 dbSNP
rs755746243 522 dbSNP
rs767252357 522 dbSNP
rs886047616 522 dbSNP
rs1376008437 526 dbSNP
rs1365401641 530 dbSNP
rs1233733960 531 dbSNP
rs957324830 535 dbSNP
rs986318958 537 dbSNP
rs910689990 538 dbSNP
rs1328826044 539 dbSNP
rs886047618 540 dbSNP
rs868594741 541 dbSNP
rs886047617 541 dbSNP
rs886047619 541 dbSNP
rs1393734883 542 dbSNP
rs1433179272 542 dbSNP
rs1258204562 544 dbSNP
rs1468929354 544 dbSNP
rs1237836541 548 dbSNP
rs227092 549 dbSNP
rs1209085533 550 dbSNP
rs143531724 552 dbSNP
rs1238129060 559 dbSNP
rs922769841 563 dbSNP
rs929308657 565 dbSNP
rs1234427651 567 dbSNP
rs1375574485 568 dbSNP
rs1306432876 571 dbSNP
rs568034723 578 dbSNP
rs887884019 579 dbSNP
rs758973253 580 dbSNP
rs1465802760 582 dbSNP
rs1055588594 584 dbSNP
rs894312164 592 dbSNP
rs1045110549 627 dbSNP
rs941339869 627 dbSNP
rs1014149927 628 dbSNP
rs1179746063 633 dbSNP
rs1024163177 637 dbSNP
rs535085191 644 dbSNP
rs1402598711 645 dbSNP
rs1464162216 651 dbSNP
rs998551161 652 dbSNP
rs765488348 657 dbSNP
rs1330703495 662 dbSNP
rs1376079188 669 dbSNP
rs537960895 672 dbSNP
rs905767242 673 dbSNP
rs1033051419 678 dbSNP
rs1211576696 681 dbSNP
rs1329120316 683 dbSNP
rs1352887931 683 dbSNP
rs3092837 685 dbSNP
rs751932227 691 dbSNP
rs118179262 704 dbSNP
rs1196226588 709 dbSNP
rs966180034 713 dbSNP
rs1353999243 715 dbSNP
rs1489132979 717 dbSNP
rs976357639 718 dbSNP
rs1212141404 727 dbSNP
rs1156910485 740 dbSNP
rs904314057 742 dbSNP
rs1017949248 744 dbSNP
rs1194294795 750 dbSNP
rs919521260 767 dbSNP
rs558184110 769 dbSNP
rs779274619 769 dbSNP
rs1476929912 772 dbSNP
rs12284748 776 dbSNP
rs951008365 777 dbSNP
rs78327467 780 dbSNP
rs1395302891 803 dbSNP
rs1206398541 804 dbSNP
rs1350711760 805 dbSNP
rs1264316873 809 dbSNP
rs1336476525 809 dbSNP
rs748879858 812 dbSNP
rs938151129 818 dbSNP
rs1415720343 820 dbSNP
rs12284801 822 dbSNP
rs1340474996 823 dbSNP
rs1316805038 825 dbSNP
rs866721145 826 dbSNP
rs1162727666 828 dbSNP
rs951512501 828 dbSNP
rs1055118181 831 dbSNP
rs1460137110 832 dbSNP
rs1420202308 834 dbSNP
rs915774985 836 dbSNP
rs949900220 848 dbSNP
rs1388354063 849 dbSNP
rs1386034128 851 dbSNP
rs1195287244 857 dbSNP
rs758492915 858 dbSNP
rs557886356 860 dbSNP
rs758912299 861 dbSNP
rs999143947 871 dbSNP
rs941488241 880 dbSNP
rs1234319831 888 dbSNP
rs1230336748 889 dbSNP
rs1268769312 889 dbSNP
rs200629108 889 dbSNP
rs886047620 889 dbSNP
rs1327530332 896 dbSNP
rs1322974277 900 dbSNP
rs1438726626 907 dbSNP
rs377571813 909 dbSNP
rs1277085369 913 dbSNP
rs754488337 915 dbSNP
rs1056987817 921 dbSNP
rs573007316 925 dbSNP
rs1264235168 930 dbSNP
rs370062602 930 dbSNP
rs1007338914 935 dbSNP
rs1376940301 940 dbSNP
rs373635753 956 dbSNP
rs1191231512 957 dbSNP
rs1455164987 962 dbSNP
rs1017350972 967 dbSNP
rs1197681760 969 dbSNP
rs1435708295 971 dbSNP
rs182586193 972 dbSNP
rs904238300 976 dbSNP
rs997701868 979 dbSNP
rs555360537 982 dbSNP
rs1232218359 1005 dbSNP
rs1373336531 1007 dbSNP
rs1304225014 1010 dbSNP
rs1487468219 1012 dbSNP
rs1026443335 1022 dbSNP
rs1330653822 1029 dbSNP
rs951033262 1031 dbSNP
rs985446753 1035 dbSNP
rs909239964 1039 dbSNP
rs1018335120 1043 dbSNP
rs1455517104 1055 dbSNP
rs1395224478 1066 dbSNP
rs899511430 1068 dbSNP
rs574005162 1071 dbSNP
rs997879955 1095 dbSNP
rs1425596093 1106 dbSNP
rs1029902749 1110 dbSNP
rs959623444 1113 dbSNP
rs1438708723 1124 dbSNP
rs1280019634 1125 dbSNP
rs1209415299 1131 dbSNP
rs990752876 1135 dbSNP
rs951647481 1144 dbSNP
rs1162715307 1152 dbSNP
rs1223225865 1154 dbSNP
rs1371482972 1156 dbSNP
rs982941041 1177 dbSNP
rs918021286 1178 dbSNP
rs1354639598 1184 dbSNP
rs1310836143 1185 dbSNP
rs963077349 1186 dbSNP
rs1157546069 1187 dbSNP
rs1409744923 1189 dbSNP
rs544263102 1189 dbSNP
rs1158824663 1190 dbSNP
rs1457287827 1191 dbSNP
rs1257327246 1196 dbSNP
rs1298655687 1204 dbSNP
rs1045548215 1206 dbSNP
rs980896382 1210 dbSNP
rs926586432 1212 dbSNP
rs368440018 1220 dbSNP
rs778005074 1220 dbSNP
rs1286401057 1222 dbSNP
rs1224597862 1226 dbSNP
rs992141209 1226 dbSNP
rs187308124 1228 dbSNP
rs1297168254 1238 dbSNP
rs1291212035 1247 dbSNP
rs575446119 1253 dbSNP
rs546023856 1255 dbSNP
rs1356041345 1265 dbSNP
rs564239571 1266 dbSNP
rs1397292114 1268 dbSNP
rs376572054 1273 dbSNP
rs1321645790 1276 dbSNP
rs945977607 1276 dbSNP
rs1041493703 1278 dbSNP
rs1163241353 1280 dbSNP
rs1288670842 1287 dbSNP
rs1351931225 1291 dbSNP
rs528218018 1292 dbSNP
rs925829168 1293 dbSNP
rs935721083 1297 dbSNP
rs1243982621 1301 dbSNP
rs939722975 1318 dbSNP
rs934634352 1327 dbSNP
rs1056890244 1328 dbSNP
rs370286603 1329 dbSNP
rs1484328440 1330 dbSNP
rs899605184 1346 dbSNP
rs1335284462 1356 dbSNP
rs1294561593 1361 dbSNP
rs1212797774 1378 dbSNP
rs1054761195 1383 dbSNP
rs1050783054 1395 dbSNP
rs887323069 1404 dbSNP
rs748141793 1405 dbSNP
rs1327548371 1409 dbSNP
rs373113342 1418 dbSNP
rs1007243818 1425 dbSNP
rs1159158739 1426 dbSNP
rs3092836 1428 dbSNP
rs1417667337 1440 dbSNP
rs1422194556 1443 dbSNP
rs1189315514 1460 dbSNP
rs1453833281 1483 dbSNP
rs1251188849 1489 dbSNP
rs1215846274 1494 dbSNP
rs1469068190 1498 dbSNP
rs962921891 1505 dbSNP
rs1202101860 1506 dbSNP
rs879335491 1507 dbSNP
rs901595023 1520 dbSNP
rs112426029 1521 dbSNP
rs1233434308 1523 dbSNP
rs1359395110 1529 dbSNP
rs1467201462 1533 dbSNP
rs1300636220 1542 dbSNP
rs577653898 1550 dbSNP
rs1368208870 1558 dbSNP
rs886047621 1572 dbSNP
rs1441263760 1585 dbSNP
rs1448227502 1587 dbSNP
rs1297976379 1597 dbSNP
rs227091 1605 dbSNP
rs913908262 1606 dbSNP
rs1006504146 1611 dbSNP
rs967246140 1612 dbSNP
rs1434623064 1618 dbSNP
rs1393415054 1622 dbSNP
rs1195578639 1625 dbSNP
rs1375271306 1626 dbSNP
rs1016941714 1630 dbSNP
rs959626196 1634 dbSNP
rs746849580 1637 dbSNP
rs770585036 1638 dbSNP
rs1251650671 1640 dbSNP
rs886047622 1641 dbSNP
rs978143944 1642 dbSNP
rs1234305333 1647 dbSNP
rs925891526 1649 dbSNP
rs924492543 1665 dbSNP
rs935830610 1669 dbSNP
rs934475897 1670 dbSNP
rs886047623 1671 dbSNP
rs757860493 1681 dbSNP
rs943226485 1682 dbSNP
rs1038725827 1684 dbSNP
rs1175615935 1693 dbSNP
rs1466572790 1694 dbSNP
rs1363472792 1696 dbSNP
rs1157260346 1699 dbSNP
rs901508381 1701 dbSNP
rs1252352162 1702 dbSNP
rs569539629 1705 dbSNP
rs1186873913 1706 dbSNP
rs1039982925 1711 dbSNP
rs1259462990 1713 dbSNP
rs1239964128 1715 dbSNP
rs554540485 1716 dbSNP
rs1349376770 1722 dbSNP
rs879831133 1731 dbSNP
rs1240821272 1732 dbSNP
rs190315580 1740 dbSNP
rs886161195 1741 dbSNP
rs1289382131 1753 dbSNP
rs1006819730 1755 dbSNP
rs1016394965 1757 dbSNP
rs921006915 1762 dbSNP
rs781777385 1764 dbSNP
rs551571814 1769 dbSNP
rs1434602105 1770 dbSNP
rs183326487 1771 dbSNP
rs759768341 1775 dbSNP
rs765483338 1776 dbSNP
rs1404769171 1779 dbSNP
rs1412896301 1782 dbSNP
rs970684092 1783 dbSNP
rs775698168 1790 dbSNP
rs746213618 1792 dbSNP
rs1050709141 1796 dbSNP
rs1474078000 1797 dbSNP
rs114847811 1800 dbSNP
rs764632866 1801 dbSNP
rs534103270 1806 dbSNP
rs1188227095 1807 dbSNP
rs1004438412 1812 dbSNP
rs1398748041 1817 dbSNP
rs1038602842 1821 dbSNP
rs958121873 1825 dbSNP
rs898764664 1828 dbSNP
rs1002371848 1829 dbSNP
rs1272096089 1833 dbSNP
rs1275874552 1838 dbSNP
rs1034273221 1844 dbSNP
rs990391005 1845 dbSNP
rs1246255105 1854 dbSNP
rs188684253 1857 dbSNP
rs1293539138 1864 dbSNP
rs1383943315 1871 dbSNP
rs1013644621 1872 dbSNP
rs1318813434 1878 dbSNP
rs80226715 1883 dbSNP
rs538284584 1884 dbSNP
rs974640620 1891 dbSNP
rs966670115 1894 dbSNP
rs1396491506 1898 dbSNP
rs193021589 1904 dbSNP
rs1475047564 1910 dbSNP
rs1371213464 1921 dbSNP
rs932988979 1922 dbSNP
rs1047368821 1923 dbSNP
rs1032926650 1928 dbSNP
rs1456440357 1930 dbSNP
rs886191311 1936 dbSNP
rs1203716161 1937 dbSNP
rs957551991 1944 dbSNP
rs941757197 1949 dbSNP
rs1469530298 1950 dbSNP
rs1292473958 1952 dbSNP
rs1038310671 1956 dbSNP
rs1210749716 1957 dbSNP
rs886047624 1960 dbSNP
rs975238633 1961 dbSNP
rs921101799 1962 dbSNP
rs1231212451 1964 dbSNP
rs1408065938 1971 dbSNP
rs148781946 1975 dbSNP
rs1012476118 1983 dbSNP
rs544709266 1989 dbSNP
rs908319176 1992 dbSNP
rs1373387298 1994 dbSNP
rs1323986602 2005 dbSNP
rs770124832 2014 dbSNP
rs939682310 2015 dbSNP
rs1169619759 2019 dbSNP
rs1430306992 2023 dbSNP
rs1046619146 2029 dbSNP
rs546092733 2036 dbSNP
rs1191135844 2037 dbSNP
rs1455315298 2042 dbSNP
rs564351975 2043 dbSNP
rs906764662 2045 dbSNP
rs1200059171 2048 dbSNP
rs1437652658 2051 dbSNP
rs1271290545 2065 dbSNP
rs999951061 2071 dbSNP
rs573109136 2072 dbSNP
rs142456486 2081 dbSNP
rs34005617 2081 dbSNP
rs1347429856 2084 dbSNP
rs1275623087 2087 dbSNP
rs1441713021 2091 dbSNP
rs1333815427 2092 dbSNP
rs562933185 2094 dbSNP
rs1010982453 2096 dbSNP
rs1055276891 2101 dbSNP
rs1171222963 2104 dbSNP
rs1435994615 2106 dbSNP
rs1352084711 2114 dbSNP
rs1425217009 2117 dbSNP
rs779747622 2124 dbSNP
rs1157681583 2132 dbSNP
rs1468267950 2134 dbSNP
rs1184709213 2150 dbSNP
rs1483677358 2152 dbSNP
rs1021493177 2154 dbSNP
rs748910879 2155 dbSNP
rs151333766 2159 dbSNP
rs1208861750 2171 dbSNP
rs574366425 2174 dbSNP
rs1013736471 2183 dbSNP
rs974547217 2192 dbSNP
rs1223492155 2193 dbSNP
rs1348725398 2197 dbSNP
rs1289997641 2198 dbSNP
rs1228726377 2199 dbSNP
rs75959910 2200 dbSNP
rs902644740 2201 dbSNP
rs1000865352 2205 dbSNP
rs1276448817 2207 dbSNP
rs543270649 2208 dbSNP
rs1317350377 2218 dbSNP
rs1213952453 2219 dbSNP
rs75293772 2221 dbSNP
rs139245552 2225 dbSNP
rs907528798 2226 dbSNP
rs1161857448 2228 dbSNP
rs941813666 2233 dbSNP
rs1417555364 2239 dbSNP
rs1219122262 2242 dbSNP
rs753553603 2244 dbSNP
rs975753610 2249 dbSNP
rs916775995 2250 dbSNP
rs1238192899 2260 dbSNP
rs1215084396 2262 dbSNP
rs1028130059 2268 dbSNP
rs1270204606 2273 dbSNP
rs3092838 2290 dbSNP
rs1333949786 2304 dbSNP
rs1291194629 2312 dbSNP
rs754611629 2319 dbSNP
rs1195374830 2325 dbSNP
rs1230022595 2327 dbSNP
rs1260466781 2334 dbSNP
rs3092839 2335 dbSNP
rs1163284087 2337 dbSNP
rs906795405 2344 dbSNP
rs185852664 2363 dbSNP
rs1427985738 2364 dbSNP
rs1390427062 2368 dbSNP
rs1404029067 2369 dbSNP
rs1320858099 2372 dbSNP
rs1460572726 2373 dbSNP
rs939797504 2376 dbSNP
rs1163118177 2384 dbSNP
rs1426088673 2386 dbSNP
rs1415094927 2387 dbSNP
rs973727870 2402 dbSNP
rs1474490372 2408 dbSNP
rs1249951277 2411 dbSNP
rs1189514071 2415 dbSNP
rs919606084 2420 dbSNP
rs1052896941 2426 dbSNP
rs1361553634 2428 dbSNP
rs938250851 2452 dbSNP
rs1322281878 2453 dbSNP
rs1296546300 2464 dbSNP
rs1212709022 2466 dbSNP
rs1326030011 2472 dbSNP
rs1366802040 2477 dbSNP
rs1448871898 2478 dbSNP
rs778439888 2480 dbSNP
rs1358381690 2482 dbSNP
rs1292167854 2483 dbSNP
rs1011438957 2501 dbSNP
rs1018387139 2514 dbSNP
rs1053060201 2519 dbSNP
rs534162872 2521 dbSNP
rs1354116233 2523 dbSNP
rs1042568820 2540 dbSNP
rs886047625 2540 dbSNP
rs996013201 2544 dbSNP
rs1454007752 2547 dbSNP
rs1265476494 2549 dbSNP
rs1030136462 2551 dbSNP
rs1192741829 2561 dbSNP
rs146547907 2564 dbSNP
rs983386242 2576 dbSNP
rs1238695431 2585 dbSNP
rs1472128412 2588 dbSNP
rs567752032 2599 dbSNP
rs907555795 2602 dbSNP
rs1345333625 2608 dbSNP
rs879796523 2608 dbSNP
rs1303008318 2609 dbSNP
rs537912224 2611 dbSNP
rs973013574 2614 dbSNP
rs562960650 2617 dbSNP
rs757803813 2633 dbSNP
rs1368813513 2635 dbSNP
rs372007058 2641 dbSNP
rs1053768317 2645 dbSNP
rs141276913 2648 dbSNP
rs1372883176 2654 dbSNP
rs947766175 2657 dbSNP
rs1169332384 2660 dbSNP
rs1381361389 2662 dbSNP
rs777786082 2663 dbSNP
rs900515200 2678 dbSNP
rs1157176514 2682 dbSNP
rs1178571809 2682 dbSNP
rs1384540603 2683 dbSNP
rs1046554624 2698 dbSNP
rs996220449 2702 dbSNP
rs1484003806 2704 dbSNP
rs768089984 2704 dbSNP
rs1210031320 2705 dbSNP
rs532373195 2705 dbSNP
rs886047626 2705 dbSNP
rs1028223202 2707 dbSNP
rs928126930 2711 dbSNP
rs2905096 2715 dbSNP
rs1338757424 2716 dbSNP
rs1450415382 2717 dbSNP
rs1314337711 2718 dbSNP
rs11558525 2719 dbSNP
rs955312830 2719 dbSNP
rs539018922 2721 dbSNP
rs768728897 2721 dbSNP
rs1242067936 2724 dbSNP
rs1258671621 2725 dbSNP
rs378840 2728 dbSNP
rs1226894373 2735 dbSNP
rs1352900392 2739 dbSNP
rs1349591727 2743 dbSNP
rs1414688151 2744 dbSNP
rs754992709 2757 dbSNP
rs1304655426 2760 dbSNP
rs1280186509 2761 dbSNP
rs1440165460 2765 dbSNP
rs453848 2767 dbSNP
rs1156722104 2771 dbSNP
rs1202439616 2775 dbSNP
rs1239340127 2779 dbSNP
rs886047627 2779 dbSNP
rs1442021324 2780 dbSNP
rs1246719124 2781 dbSNP
rs1257660999 2781 dbSNP
rs765253087 2781 dbSNP
rs1177162363 2784 dbSNP
rs1289365149 2796 dbSNP
rs1339156765 2798 dbSNP
rs866933293 2798 dbSNP
rs935619523 2800 dbSNP
rs1052689746 2807 dbSNP
rs1314959279 2810 dbSNP
rs894021798 2811 dbSNP
rs866054461 2833 dbSNP
rs946758946 2834 dbSNP
rs1396631973 2835 dbSNP
rs1384303852 2839 dbSNP
rs186644530 2843 dbSNP
rs1000441493 2851 dbSNP
rs1459008025 2854 dbSNP
rs747702040 2860 dbSNP
rs1389191588 2865 dbSNP
rs568150944 2866 dbSNP
rs974245461 2866 dbSNP
rs191399133 2867 dbSNP
rs552795979 2868 dbSNP
rs530721400 2869 dbSNP
rs1469375533 2871 dbSNP
rs959280231 2880 dbSNP
rs540428580 2893 dbSNP
rs890276332 2898 dbSNP
rs990485308 2899 dbSNP
rs373927479 2900 dbSNP
rs918162167 2908 dbSNP
rs1209557222 2910 dbSNP
rs1267795735 2912 dbSNP
rs796219954 2912 dbSNP
rs1246135081 2915 dbSNP
rs555227643 2921 dbSNP
rs1014855837 2922 dbSNP
rs963603073 2924 dbSNP
rs973042702 2926 dbSNP
rs529522596 2932 dbSNP
rs886047628 2936 dbSNP
rs1324992100 2945 dbSNP
rs1384822866 2947 dbSNP
rs1392583511 2952 dbSNP
rs770767475 2958 dbSNP
rs1461412152 2960 dbSNP
rs1387859639 2962 dbSNP
rs1169866522 2976 dbSNP
rs1449712390 2981 dbSNP
rs1251938302 2985 dbSNP
rs1198637493 2989 dbSNP
rs573692593 2991 dbSNP
rs981822562 2994 dbSNP
rs866557973 3001 dbSNP
rs936740894 3013 dbSNP
rs1054266374 3014 dbSNP
rs145076930 3023 dbSNP
rs935528568 3027 dbSNP
rs1343175749 3028 dbSNP
rs537345228 3028 dbSNP
rs1202494468 3032 dbSNP
rs1434556748 3033 dbSNP
rs996174086 3038 dbSNP
rs1258063242 3040 dbSNP
rs183664907 3043 dbSNP
rs1309342997 3045 dbSNP
rs1368568788 3045 dbSNP
rs1429783357 3061 dbSNP
rs1393930026 3067 dbSNP
rs891012594 3068 dbSNP
rs3092844 3073 dbSNP
rs1015409440 3085 dbSNP
rs886047629 3092 dbSNP
rs79807288 3094 dbSNP
rs1250193649 3101 dbSNP
rs1027147966 3103 dbSNP
rs899832360 3106 dbSNP
rs1376145410 3118 dbSNP
rs934088353 3122 dbSNP
rs544596323 3124 dbSNP
rs1425859390 3129 dbSNP
rs3092845 3137 dbSNP
rs1227504829 3138 dbSNP
rs1296346692 3159 dbSNP
rs1348592664 3159 dbSNP
rs1290184506 3162 dbSNP
rs763158496 3171 dbSNP
rs1015132568 3175 dbSNP
rs1410343731 3187 dbSNP
rs1358137450 3190 dbSNP
rs1395635614 3196 dbSNP
rs764033869 3199 dbSNP
rs181377742 3205 dbSNP
rs1343254576 3216 dbSNP
rs1222514012 3223 dbSNP
rs1472489818 3229 dbSNP
rs994703895 3230 dbSNP
rs3092852 3231 dbSNP
rs567730651 3239 dbSNP
rs1278339570 3245 dbSNP
rs560517151 3249 dbSNP
rs1208040483 3255 dbSNP
rs969006284 3256 dbSNP
rs1444367655 3257 dbSNP
rs1224565244 3258 dbSNP
rs981716144 3259 dbSNP
rs1279552167 3267 dbSNP
rs1208313921 3270 dbSNP
rs1034795987 3276 dbSNP
rs936815157 3277 dbSNP
rs1289975865 3278 dbSNP
rs1228934862 3287 dbSNP
rs956622250 3296 dbSNP
rs1378276276 3299 dbSNP
rs531912436 3303 dbSNP
rs1212009810 3313 dbSNP
rs1267211068 3320 dbSNP
rs886047630 3326 dbSNP
rs988337502 3328 dbSNP
rs550040386 3335 dbSNP
rs571703745 3337 dbSNP
rs915388097 3342 dbSNP
rs1161745621 3346 dbSNP
rs946992128 3352 dbSNP
rs1458241893 3353 dbSNP
rs886047631 3355 dbSNP
rs750759736 3362 dbSNP
rs539080948 3369 dbSNP
rs921293408 3379 dbSNP
rs890475912 3385 dbSNP
rs754664818 3387 dbSNP
rs1037340869 3393 dbSNP
rs4585 3394 dbSNP
rs752296217 3395 dbSNP
rs4987113 3396 dbSNP
rs11558526 3406 dbSNP
rs1164846644 3408 dbSNP
rs995739893 3409 dbSNP
rs1026828170 3413 dbSNP
rs4987114 3414 dbSNP
rs898989110 3417 dbSNP
rs182082753 3429 dbSNP
rs994734771 3436 dbSNP
rs1311151993 3440 dbSNP
rs878931713 3443 dbSNP
rs1024567059 3445 dbSNP
rs1341939431 3449 dbSNP
rs1380046674 3458 dbSNP
rs1431886771 3458 dbSNP
rs1044975570 3469 dbSNP
rs905096677 3485 dbSNP
rs970354150 3490 dbSNP
rs1385944085 3496 dbSNP
rs777082747 3497 dbSNP
rs1247612959 3502 dbSNP
rs1035067652 3509 dbSNP
rs1250091038 3511 dbSNP
rs550004981 3517 dbSNP
rs751582824 3525 dbSNP
rs1031665809 3527 dbSNP
rs1290106077 3528 dbSNP
rs1244750733 3531 dbSNP
rs958346116 3543 dbSNP
rs1322185912 3546 dbSNP
rs1273302932 3551 dbSNP
rs990018655 3552 dbSNP
rs1343901235 3555 dbSNP
rs1297936003 3558 dbSNP
rs1022486096 3561 dbSNP
rs1359130012 3562 dbSNP
rs968197352 3565 dbSNP
rs975549009 3567 dbSNP
rs921531831 3572 dbSNP
rs1288453768 3579 dbSNP
rs912006598 3580 dbSNP
rs1186003088 3584 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions 293T , 95C , 95D , U87MGD , U87MG , M059K
Disease AGCTATGAAGTTATCACAGAAAGATAACATA;
Location of target site 3'UTR
Tools used in this research MicroCosm , miRanda , miRBase Target Database
Original Description (Extracted from the article) ... "We identified that miR- 101 could efficiently target DNA-PKcs and ATM via binding to the 3'- UTR of DNA-PKcs or ATM mRNA.//To verify whether DNA-PKcs or ATM is a target of miR-101 ...

- Yan D; Ng WL; Zhang X; Wang P; Zhang Z; Mo et al., 2010, PloS one.

Article - Yan D; Ng WL; Zhang X; Wang P; Zhang Z; Mo et al.
- PloS one, 2010
BACKGROUND: Radiotherapy kills tumor-cells by inducing DNA double strand breaks (DSBs). However, the efficient repair of tumors frequently prevents successful treatment. Therefore, identifying new practical sensitizers is an essential step towards successful radiotherapy. In this study, we tested the new hypothesis: identifying the miRNAs to target DNA DSB repair genes could be a new way for sensitizing tumors to ionizing radiation. PRINCIPAL FINDINGS: HERE, WE CHOSE TWO GENES: DNA-PKcs (an essential factor for non-homologous end-joining repair) and ATM (an important checkpoint regulator for promoting homologous recombination repair) as the targets to search their regulating miRNAs. By combining the database search and the bench work, we picked out miR-101. We identified that miR-101 could efficiently target DNA-PKcs and ATM via binding to the 3'- UTR of DNA-PKcs or ATM mRNA. Up-regulating miR-101 efficiently reduced the protein levels of DNA-PKcs and ATM in these tumor cells and most importantly, sensitized the tumor cells to radiation in vitro and in vivo. CONCLUSIONS: These data demonstrate for the first time that miRNAs could be used to target DNA repair genes and thus sensitize tumors to radiation. These results provide a new way for improving tumor radiotherapy.
LinkOut: [PMID: 20617180]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE26953 Aortic valvular endothelial cells 0.604 8.9e-4 0.681 1.2e-4 24 Click to see details
GSE28260 Renal cortex and medulla 0.748 1.6e-3 0.703 3.7e-3 13 Click to see details
GSE19536 Breast cancer -0.267 3.6e-3 -0.267 3.6e-3 100 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.522 9.1e-3 0.553 5.7e-3 20 Click to see details
GSE19783 ER- ER- breast cancer -0.256 1.1e-2 -0.223 2.4e-2 79 Click to see details
GSE28544 Breast cancer -0.369 3.8e-2 -0.318 6.5e-2 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.295 7.6e-2 0.244 1.2e-1 25 Click to see details
GSE17498 Multiple myeloma 0.21 9.7e-2 0.216 9.0e-2 40 Click to see details
GSE32688 Pancreatic cancer -0.231 1.0e-1 -0.378 1.6e-2 32 Click to see details
GSE42095 Differentiated embryonic stem cells -0.244 1.3e-1 -0.267 1.1e-1 23 Click to see details
GSE21032 Prostate cancer -0.111 1.6e-1 -0.029 4.0e-1 83 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.676 1.6e-1 0.400 3.0e-1 4 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.133 2.6e-1 0.342 4.7e-2 25 Click to see details
GSE19350 CNS germ cell tumors -0.191 2.8e-1 -0.042 4.5e-1 12 Click to see details
GSE21687 Ependynoma primary tumors 0.059 3.2e-1 0.081 2.6e-1 64 Click to see details
GSE38226 Liver fibrosis 0.101 3.3e-1 0.131 2.9e-1 21 Click to see details
GSE19783 ER+ ER+ breast cancer -0.1 3.4e-1 0.027 4.6e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KICH 0.509 0 0.250 0.11 25 Click to see details
PRAD -0.235 0.05 -0.106 0.23 50 Click to see details
KIRP -0.282 0.06 -0.370 0.02 32 Click to see details
PCPG -0.936 0.11 -1.000 0.5 3 Click to see details
PAAD 0.656 0.17 0.200 0.4 4 Click to see details
BLCA 0.242 0.17 0.235 0.18 17 Click to see details
UCEC 0.21 0.19 -0.019 0.47 19 Click to see details
BRCA -0.095 0.2 -0.108 0.16 84 Click to see details
KIRC 0.093 0.23 0.101 0.21 68 Click to see details
LIHC -0.099 0.25 -0.013 0.46 49 Click to see details
HNSC 0.1 0.26 0.041 0.4 42 Click to see details
LUSC 0.102 0.27 0.063 0.35 38 Click to see details
THCA 0.035 0.4 -0.013 0.46 59 Click to see details
STAD 0.042 0.41 0.118 0.26 32 Click to see details
LUAD 0.065 0.42 0.014 0.48 12 Click to see details
CESC -0.177 0.44 -0.500 0.33 3 Click to see details
ESCA -0.023 0.47 -0.027 0.47 11 Click to see details
CHOL -0.01 0.49 0.233 0.27 9 Click to see details
CHOL -0.01 0.49 0.233 0.27 9 Click to see details
CHOL -0.01 0.49 0.233 0.27 9 Click to see details
CHOL -0.01 0.49 0.233 0.27 9 Click to see details
63 hsa-miR-101-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005558 PRKDC protein kinase, DNA-activated, catalytic polypeptide 2 1
MIRT005559 ATM ATM serine/threonine kinase 3 1
MIRT038714 TMSB10 thymosin beta 10 1 1
MIRT064840 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT066165 PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma 2 2
MIRT089580 MAT2A methionine adenosyltransferase 2A 2 4
MIRT095008 AFF4 AF4/FMR2 family member 4 2 2
MIRT266193 TXNIP thioredoxin interacting protein 2 2
MIRT280282 CMPK1 cytidine/uridine monophosphate kinase 1 2 2
MIRT329427 C5ORF51 chromosome 5 open reading frame 51 2 2
MIRT331963 TEAD1 TEA domain transcription factor 1 2 2
MIRT333607 EFHD2 EF-hand domain family member D2 2 2
MIRT355843 AIMP1 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 2 2
MIRT447684 MTPAP mitochondrial poly(A) polymerase 2 2
MIRT451781 USP36 ubiquitin specific peptidase 36 2 2
MIRT452204 TMEM68 transmembrane protein 68 2 4
MIRT465575 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT466445 TFAM transcription factor A, mitochondrial 2 8
MIRT466769 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 2 8
MIRT470377 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT471684 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT480906 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT491030 FDX1 ferredoxin 1 2 4
MIRT506124 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 8
MIRT506610 MARCH6 membrane associated ring-CH-type finger 6 2 8
MIRT520592 TMEM55B phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 2 6
MIRT531128 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT532220 CCDC117 coiled-coil domain containing 117 2 2
MIRT532787 RBM22 RNA binding motif protein 22 2 2
MIRT535709 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT539026 ATXN7L1 ataxin 7 like 1 2 4
MIRT540298 TMA16 translation machinery associated 16 homolog 2 2
MIRT547194 PAWR pro-apoptotic WT1 regulator 2 2
MIRT548935 CDK17 cyclin dependent kinase 17 2 2
MIRT550033 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT552244 DUSP3 dual specificity phosphatase 3 2 2
MIRT553557 TMEM161B transmembrane protein 161B 2 2
MIRT555067 PXK PX domain containing serine/threonine kinase like 2 2
MIRT555493 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT555824 PAX9 paired box 9 2 2
MIRT556614 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT559225 BLMH bleomycin hydrolase 2 2
MIRT560200 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT568262 BMP2K BMP2 inducible kinase 2 2
MIRT573847 PPA1 pyrophosphatase (inorganic) 1 2 2
MIRT609581 GJD2 gap junction protein delta 2 2 2
MIRT609940 MYCBP MYC binding protein 2 2
MIRT627026 CREBL2 cAMP responsive element binding protein like 2 2 2
MIRT679122 NMNAT1 nicotinamide nucleotide adenylyltransferase 1 2 2
MIRT685557 TXK TXK tyrosine kinase 2 2
MIRT686204 ZNF451 zinc finger protein 451 2 2
MIRT694309 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT698793 STK38 serine/threonine kinase 38 2 2
MIRT702499 KIAA0040 KIAA0040 2 2
MIRT716978 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT734345 PVT1 Pvt1 oncogene (non-protein coding) 0 0
MIRT734346 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 0 0
MIRT735948 COL10A1 collagen type X alpha 1 chain 3 0
MIRT735950 COL12A1 collagen type XII alpha 1 chain 3 0
MIRT735954 TGFBR1 transforming growth factor beta receptor 1 3 0
MIRT737208 GINS1 GINS complex subunit 1 2 0
MIRT737457 DONSON downstream neighbor of SON 4 0
MIRT756268 DUSP6 dual specificity phosphatase 6 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-101 Cyclosporin A(CsA) approved 5284373 Quantitative real-time PCR human trophoblast (HT) cells 24453045 2014 down-regulated
miR-101 Sodium butyrate NULL 5222465 Quantitative real-time PCR Burkitt lymphoma cells 24577510 2014 up-regulated
miR-101 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-101 Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
miR-101 Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
miR-101 Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
miR-101 CDF(analogues of curcumin) NULL NULL Quantitative real-time PCR pancreatic cancer cells 22108826 2012 up-regulated
miR-101 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 down-regulated
miR-101 Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 down-regulated
miR-101 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) NULL 47289 Microarray rat lung 18780894 2008 down-regulated
miR-101 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) NULL 47289 Northern blot rat lung 18780894 2008 down-regulated
miR-101 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) NULL 47289 Quantitative real-time PCR rat lung 18780894 2008 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-101-5p Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-101-5p Verapamil 2520 NSC272366 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-101-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-101-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-101-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-101-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-101-5p Palbociclib 5330286 NSC758247 approved sensitive cell line (T47D)
hsa-miR-101-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-101-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-101-5p 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-miR-101-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-101-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR4)
hsa-miR-101-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-101-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR1)
hsa-miR-101-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-101-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-101-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-101-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-101-5p Cisplatin 5460033 NSC119875 approved resistant cell line (OVCAR3)

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