miRTarBase - #MIRT005926


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pre-miRNA Information
pre-miRNA hsa-mir-424   
Genomic Coordinates chrX: 134546614 - 134546711
Synonyms MIR322, MIRN424, hsa-mir-424, miRNA424, MIR424
Description Homo sapiens miR-424 stem-loop
Comment This hairpin precursor expresses a 5' arm product, named miR-424, in human promyelocytic leukemia (HL-60) cells . The level of expression of miR-424 was shown to be up-regulated 48 hours after TPA-induction. The sequence is orthologous to the experimentally verified rat miR-322 locus (MIR:MI0000589), which expresses its mature product from the 3' arm of the hairpin. The human miR-424 hairpin does not appear to contain the miR-322 sequence.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-424-5p
Sequence 11| CAGCAGCAAUUCAUGUUUUGAA |32
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 X - 134546697 29233923 MiREDiBase
A-to-I 8 X - 134546694 17604727 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs888095819 1 dbSNP
rs1486362336 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HIF1A   
Synonyms HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
Description hypoxia inducible factor 1 alpha subunit
Transcript NM_181054   
Other Transcripts NM_001530   
Expression
Putative miRNA Targets on HIF1A
3'UTR of HIF1A
(miRNA target sites are highlighted)		 
>HIF1A|NM_181054|3'UTR
   1 CATGTAGACTGCTGGGGCAATCAATGGATGAAAGTGGATTACCACAGCTGACCAGTTATGATTGTGAAGTTAATGCTCCT
  81 ATACAAGGCAGCAGAAACCTACTGCAGGGTGAAGAATTACTCAGAGCTTTGGATCAAGTTAACTGAGCTTTTTCTTAATT
 161 TCATTCCTTTTTTTGGACACTGGTGGCTCATTACCTAAAGCAGTCTATTTATATTTTCTACATCTAATTTTAGAAGCCTG
 241 GCTACAATACTGCACAAACTTGGTTAGTTCAATTTTGATCCCCTTTCTACTTAATTTACATTAATGCTCTTTTTTAGTAT
 321 GTTCTTTAATGCTGGATCACAGACAGCTCATTTTCTCAGTTTTTTGGTATTTAAACCATTGCATTGCAGTAGCATCATTT
 401 TAAAAAATGCACCTTTTTATTTATTTATTTTTGGCTAGGGAGTTTATCCCTTTTTCGAATTATTTTTAAGAAGATGCCAA
 481 TATAATTTTTGTAAGAAGGCAGTAACCTTTCATCATGATCATAGGCAGTTGAAAAATTTTTACACCTTTTTTTTCACATT
 561 TTACATAAATAATAATGCTTTGCCAGCAGTACGTGGTAGCCACAATTGCACAATATATTTTCTTAAAAAATACCAGCAGT
 641 TACTCATGGAATATATTCTGCGTTTATAAAACTAGTTTTTAAGAAGAAATTTTTTTTGGCCTATGAAATTGTTAAACCTG
 721 GAACATGACATTGTTAATCATATAATAATGATTCTTAAATGCTGTATGGTTTATTATTTAAATGGGTAAAGCCATTTACA
 801 TAATATAGAAAGATATGCATATATCTAGAAGGTATGTGGCATTTATTTGGATAAAATTCTCAATTCAGAGAAATCATCTG
 881 ATGTTTCTATAGTCACTTTGCCAGCTCAAAAGAAAACAATACCCTATGTAGTTGTGGAAGTTTATGCTAATATTGTGTAA
 961 CTGATATTAAACCTAAATGTTCTGCCTACCCTGTTGGTATAAAGATATTTTGAGCAGACTGTAAACAAGAAAAAAAAAAT
1041 CATGCATTCTTAGCAAAATTGCCTAGTATGTTAATTTGCTCAAAATACAATGTTTGATTTTATGCACTTTGTCGCTATTA
1121 ACATCCTTTTTTTCATGTAGATTTCAATAATTGAGTAATTTTAGAAGCATTATTTTAGGAATATATAGTTGTCACAGTAA
1201 ATATCTTGTTTTTTCTATGTACATTGTACAAATTTTTCATTCCTTTTGCTCTTTGTGGTTGGATCTAACACTAACTGTAT
1281 TGTTTTGTTACATCAAATAAACATCTTCTGTGGACCAGGCAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aaguUUUGUACUUAACGACGac 5'
              :| : | || |||||:  
Target 5' taatGATTCTTAAATGCTGTat 3'
 746 - 767 114.00 -6.02
2 
miRNA  3' aaguuuuGUAC--UUAACGACgac 5'
                 ||||  :| |||||   
Target 5' -------CATGTAGACTGCTGggg 3'
 1 - 17 113.00 -10.20
3 
miRNA  3' aaguuuuGUACUUAACGACgac 5'
                 | | || |||||   
Target 5' gtatgttCTTTAA-TGCTGgat 3'
 317 - 337 106.00 -6.84
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
709474 18 ClinVar
COSM8236443 25 COSMIC
COSM2247247 35 COSMIC
COSM956814 48 COSMIC
COSM2247248 50 COSMIC
COSM1159287 53 COSMIC
COSM9470578 72 COSMIC
COSM3386615 73 COSMIC
COSM7702681 79 COSMIC
COSM8720098 82 COSMIC
COSM1158010 89 COSMIC
COSM4577931 90 COSMIC
COSM6328155 92 COSMIC
COSM4636919 104 COSMIC
COSN31598380 154 COSMIC
COSN22510195 156 COSMIC
COSN30146484 163 COSMIC
COSN30479229 168 COSMIC
COSN5853537 175 COSMIC
COSN20389672 179 COSMIC
COSN31497155 184 COSMIC
COSN20087972 192 COSMIC
COSN30511452 209 COSMIC
COSN26307819 237 COSMIC
COSN30166240 249 COSMIC
COSN31513196 252 COSMIC
COSN21620339 254 COSMIC
COSN24313377 271 COSMIC
COSN20111388 277 COSMIC
COSN20066277 279 COSMIC
COSN30524741 305 COSMIC
COSN31535736 366 COSMIC
COSN26581982 390 COSMIC
COSN31595948 448 COSMIC
COSN31569975 458 COSMIC
COSN26586676 500 COSMIC
COSN31611055 608 COSMIC
COSN30541333 683 COSMIC
COSN18936091 787 COSMIC
COSN31585350 813 COSMIC
COSN23687473 821 COSMIC
COSN8846910 826 COSMIC
COSN31547288 871 COSMIC
COSN31606639 871 COSMIC
COSN9089004 881 COSMIC
COSN31484977 897 COSMIC
COSN29683013 1040 COSMIC
COSN21324998 1080 COSMIC
COSN1169739 1134 COSMIC
COSN31593408 1215 COSMIC
COSN31516638 1232 COSMIC
COSN31563647 1316 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs539549822 5 dbSNP
rs772563698 15 dbSNP
rs74054863 18 dbSNP
rs761301966 25 dbSNP
rs764342882 27 dbSNP
rs1434107649 30 dbSNP
rs777173441 32 dbSNP
rs148149561 45 dbSNP
rs762084100 46 dbSNP
rs1332732959 48 dbSNP
rs1400361157 51 dbSNP
rs1802821 52 dbSNP
rs765575235 56 dbSNP
rs545874061 60 dbSNP
rs762942023 63 dbSNP
rs758032673 64 dbSNP
rs1294810529 71 dbSNP
rs1315936022 72 dbSNP
rs1220369809 75 dbSNP
rs1354416944 79 dbSNP
rs1002016670 80 dbSNP
rs1258843938 82 dbSNP
rs1334246808 84 dbSNP
rs766542880 85 dbSNP
rs140173615 90 dbSNP
rs754986249 92 dbSNP
rs780928465 93 dbSNP
rs559651239 99 dbSNP
rs145319047 103 dbSNP
rs1325345716 105 dbSNP
rs1172010116 111 dbSNP
rs1295805684 112 dbSNP
rs1423792468 115 dbSNP
rs1434851318 120 dbSNP
rs1366526923 127 dbSNP
rs1404187796 128 dbSNP
rs1162266976 129 dbSNP
rs777407997 132 dbSNP
rs759636243 142 dbSNP
rs1389320297 145 dbSNP
rs770333662 146 dbSNP
rs371720529 148 dbSNP
rs1387964413 149 dbSNP
rs1338114141 152 dbSNP
rs778533208 153 dbSNP
rs747441284 156 dbSNP
rs1026312234 157 dbSNP
rs552985977 165 dbSNP
rs371778537 166 dbSNP
rs769316153 167 dbSNP
rs1292325060 168 dbSNP
rs779790779 168 dbSNP
rs780828413 168 dbSNP
rs1322499060 169 dbSNP
rs1215298795 173 dbSNP
rs1284371531 178 dbSNP
rs1489469817 181 dbSNP
rs777085247 182 dbSNP
rs762278418 186 dbSNP
rs1472198228 188 dbSNP
rs2057482 192 dbSNP
rs773559645 194 dbSNP
rs763289041 196 dbSNP
rs1210541354 200 dbSNP
rs542082268 202 dbSNP
rs750111993 208 dbSNP
rs964865492 222 dbSNP
rs978881402 231 dbSNP
rs1272811246 236 dbSNP
rs775751381 241 dbSNP
rs1343396726 242 dbSNP
rs561963703 247 dbSNP
rs1272414694 248 dbSNP
rs983334130 253 dbSNP
rs1033251976 254 dbSNP
rs769353565 258 dbSNP
rs1406298050 263 dbSNP
rs530984621 263 dbSNP
rs1203608510 264 dbSNP
rs549497743 268 dbSNP
rs1307099949 270 dbSNP
rs1249381070 271 dbSNP
rs199915104 273 dbSNP
rs397897404 273 dbSNP
rs5809121 273 dbSNP
rs913568799 283 dbSNP
rs563032969 292 dbSNP
rs1477633716 294 dbSNP
rs949034822 299 dbSNP
rs981877125 300 dbSNP
rs949635893 307 dbSNP
rs1199642529 325 dbSNP
rs1249880441 333 dbSNP
rs532181605 337 dbSNP
rs551891037 355 dbSNP
rs1483509684 356 dbSNP
rs982365060 360 dbSNP
rs926344697 373 dbSNP
rs1199119871 377 dbSNP
rs937859002 380 dbSNP
rs926624286 385 dbSNP
rs1224815816 389 dbSNP
rs1348150414 390 dbSNP
rs938038646 399 dbSNP
rs1200937897 402 dbSNP
rs1037532137 403 dbSNP
rs1331894483 404 dbSNP
rs1413747297 419 dbSNP
rs1053786420 437 dbSNP
rs1170221751 456 dbSNP
rs893855163 457 dbSNP
rs763243537 458 dbSNP
rs1432176686 460 dbSNP
rs1309109880 463 dbSNP
rs1041908240 464 dbSNP
rs1473015674 478 dbSNP
rs1365494899 481 dbSNP
rs565632163 483 dbSNP
rs1403254921 486 dbSNP
rs151303260 487 dbSNP
rs1442274612 490 dbSNP
rs1297315230 492 dbSNP
rs1279938106 502 dbSNP
rs1008558586 508 dbSNP
rs17099190 518 dbSNP
rs1019564762 521 dbSNP
rs1266893123 522 dbSNP
rs140525186 530 dbSNP
rs1293213243 547 dbSNP
rs996483325 547 dbSNP
rs1026672127 555 dbSNP
rs1308966626 556 dbSNP
rs1048073800 558 dbSNP
rs1291015828 559 dbSNP
rs952532711 564 dbSNP
rs890474693 593 dbSNP
rs1401402955 594 dbSNP
rs1410435090 597 dbSNP
rs1161740541 598 dbSNP
rs1472599652 599 dbSNP
rs1246737090 602 dbSNP
rs1185844172 608 dbSNP
rs982562264 613 dbSNP
rs1248001518 615 dbSNP
rs1485359835 632 dbSNP
rs186070865 634 dbSNP
rs1184337665 636 dbSNP
rs1008828153 640 dbSNP
rs1016170938 640 dbSNP
rs970960593 648 dbSNP
rs1017666271 649 dbSNP
rs900581021 662 dbSNP
rs1356614289 663 dbSNP
rs982312779 665 dbSNP
rs1432702227 675 dbSNP
rs1417832408 681 dbSNP
rs1321218907 682 dbSNP
rs112980101 690 dbSNP
rs1431556853 704 dbSNP
rs537228141 710 dbSNP
rs1346981030 713 dbSNP
rs1000351887 718 dbSNP
rs926907138 723 dbSNP
rs751806225 725 dbSNP
rs1165838369 735 dbSNP
rs1448086868 741 dbSNP
rs1305448254 742 dbSNP
rs1390096297 743 dbSNP
rs1451785185 746 dbSNP
rs1169620714 749 dbSNP
rs1385201243 757 dbSNP
rs1033135776 762 dbSNP
rs1225899795 769 dbSNP
rs1293545948 769 dbSNP
rs1423265139 771 dbSNP
rs34873475 778 dbSNP
rs1341271847 783 dbSNP
rs1325634233 787 dbSNP
rs956362576 792 dbSNP
rs8019084 794 dbSNP
rs762252347 801 dbSNP
rs945443994 815 dbSNP
rs1042515017 817 dbSNP
rs1287270892 822 dbSNP
rs767862625 837 dbSNP
rs1428202134 847 dbSNP
rs1370274736 867 dbSNP
rs1228951010 872 dbSNP
rs1314065298 879 dbSNP
rs1357227551 887 dbSNP
rs981762514 890 dbSNP
rs1430768103 891 dbSNP
rs1248034618 893 dbSNP
rs926396778 900 dbSNP
rs1040910292 902 dbSNP
rs879291501 913 dbSNP
rs996771147 922 dbSNP
rs973110354 926 dbSNP
rs952877554 928 dbSNP
rs920448595 933 dbSNP
rs929103345 935 dbSNP
rs1310343873 936 dbSNP
rs1048503409 937 dbSNP
rs1047656959 953 dbSNP
rs888154356 954 dbSNP
rs1346293284 962 dbSNP
rs190860864 967 dbSNP
rs1408156600 985 dbSNP
rs1350131716 994 dbSNP
rs1299083231 995 dbSNP
rs1242865466 996 dbSNP
rs944737744 1000 dbSNP
rs1463890765 1001 dbSNP
rs539881963 1005 dbSNP
rs773972883 1016 dbSNP
rs1357928211 1020 dbSNP
rs1443359225 1027 dbSNP
rs1176055068 1028 dbSNP
rs1470597308 1029 dbSNP
rs1015368010 1030 dbSNP
rs1430709945 1030 dbSNP
rs971292665 1030 dbSNP
rs1165437560 1040 dbSNP
rs1039002996 1041 dbSNP
rs1178692650 1042 dbSNP
rs1414641588 1054 dbSNP
rs750960087 1073 dbSNP
rs900632992 1082 dbSNP
rs534696980 1085 dbSNP
rs867054308 1090 dbSNP
rs180837209 1091 dbSNP
rs1033476211 1093 dbSNP
rs1308063073 1106 dbSNP
rs573160553 1111 dbSNP
rs891975089 1114 dbSNP
rs989725139 1115 dbSNP
rs1436031645 1119 dbSNP
rs915224690 1120 dbSNP
rs1408971422 1124 dbSNP
rs186481938 1126 dbSNP
rs978566180 1127 dbSNP
rs1010804073 1132 dbSNP
rs370476266 1133 dbSNP
rs1364013357 1134 dbSNP
rs1160909738 1137 dbSNP
rs1421701348 1142 dbSNP
rs114812759 1148 dbSNP
rs1024591004 1149 dbSNP
rs756658648 1152 dbSNP
rs972050428 1154 dbSNP
rs1003250403 1157 dbSNP
rs1380222271 1165 dbSNP
rs1450147761 1166 dbSNP
rs1033348128 1186 dbSNP
rs574800089 1193 dbSNP
rs1206902487 1198 dbSNP
rs958994442 1203 dbSNP
rs1350125414 1205 dbSNP
rs778376665 1208 dbSNP
rs1241371052 1209 dbSNP
rs911949361 1209 dbSNP
rs944788994 1209 dbSNP
rs920314952 1218 dbSNP
rs1314742202 1220 dbSNP
rs1385575406 1224 dbSNP
rs1433694893 1247 dbSNP
rs752265561 1252 dbSNP
rs983676896 1259 dbSNP
rs555623016 1262 dbSNP
rs921108454 1264 dbSNP
rs1446294210 1287 dbSNP
rs1269456542 1289 dbSNP
rs765677998 1292 dbSNP
rs1447522222 1300 dbSNP
rs1262471493 1302 dbSNP
rs1206996164 1309 dbSNP
rs561456816 1312 dbSNP
rs1487616499 1317 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HUVECs , MVECs , BOECs , MBECs
Location of target site 3'UTR
Tools used in this research miRanda
Original Description (Extracted from the article) ... "Our芒鈧鈥歴tudies芒鈧鈥歴how芒鈧鈥歵hat芒鈧鈥歮iR-424芒鈧鈥歩s芒鈧鈥歛芒鈧鈥歝ritical芒鈧鈥歮ediator芒鈧鈥歰f芒鈧鈥歰xygen-dependent芒鈧鈥歝hanges芒鈧鈥歩n芒鈧鈥欵Cs芒鈧鈥歛nd芒鈧鈥歩s芒鈧鈥歱hysiologically芒鈧鈥歶pregulated芒鈧鈥歩n芒鈧鈥歵issues芒鈧鈥歶ndergoing芒鈧鈥歷ascular芒鈧鈥歳emodeling芒鈧鈥歛nd芒鈧鈥歛ngiogenesis.芒鈧鈥歐e芒鈧鈥歱ropose芒鈧鈥歵hat芒鈧鈥欵Cs芒鈧鈥歳espond芒鈧鈥歵o芒鈧鈥歨ypoxia芒鈧鈥歜y芒鈧鈥歶pregulating芒鈧鈥欳/EBP脦卤 ...

- Ghosh G; Subramanian IV; Adhikari N; Zhang et al., 2010, The Journal of clinical investigation.

Article - Ghosh G; Subramanian IV; Adhikari N; Zhang et al.
- The Journal of clinical investigation, 2010
Adaptive changes to oxygen availability are critical for cell survival and tissue homeostasis. Prolonged oxygen deprivation due to reduced blood flow to cardiac or peripheral tissues can lead to myocardial infarction and peripheral vascular disease, respectively. Mammalian cells respond to hypoxia by modulating oxygen-sensing transducers that stabilize the transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha), which transactivates genes governing angiogenesis and metabolic pathways. Oxygen-dependent changes in HIF-1alpha levels are regulated by proline hydroxylation and proteasomal degradation. Here we provide evidence for what we believe is a novel mechanism regulating HIF-1alpha levels in isolated human ECs during hypoxia. Hypoxia differentially increased microRNA-424 (miR-424) levels in ECs. miR-424 targeted cullin 2 (CUL2), a scaffolding protein critical to the assembly of the ubiquitin ligase system, thereby stabilizing HIF-alpha isoforms. Hypoxia-induced miR-424 was regulated by PU.1-dependent transactivation. PU.1 levels were increased in hypoxic endothelium by RUNX-1 and C/EBPalpha. Furthermore, miR-424 promoted angiogenesis in vitro and in mice, which was blocked by a specific morpholino. The rodent homolog of human miR-424, mu-miR-322, was significantly upregulated in parallel with HIF-1alpha in experimental models of ischemia. These results suggest that miR-322/424 plays an important physiological role in post-ischemic vascular remodeling and angiogenesis.
LinkOut: [PMID: 20972335]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38974 Chronic obstructive pulmonary disease 0.615 5.3e-4 0.600 7.6e-4 25 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.587 3.3e-3 0.747 7.7e-5 20 Click to see details
GSE27834 Pluripotent stem cells 0.523 1.9e-2 0.568 1.1e-2 16 Click to see details
GSE17498 Multiple myeloma 0.29 3.5e-2 0.428 2.9e-3 40 Click to see details
GSE14794 Lymphoblastoid cells -0.185 4.0e-2 -0.083 2.2e-1 90 Click to see details
GSE21032 Prostate cancer 0.128 1.2e-1 0.141 1.0e-1 83 Click to see details
GSE21687 Ependynoma primary tumors 0.124 1.6e-1 0.457 7.4e-5 64 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.348 1.8e-1 -0.183 3.2e-1 9 Click to see details
GSE19350 CNS germ cell tumors -0.29 1.8e-1 -0.068 4.2e-1 12 Click to see details
GSE28544 Breast cancer 0.194 1.8e-1 0.245 1.2e-1 24 Click to see details
GSE17306 Multiple myeloma 0.128 1.9e-1 0.163 1.3e-1 49 Click to see details
GSE28260 Renal cortex and medulla -0.256 2.0e-1 -0.214 2.4e-1 13 Click to see details
GSE19783 ER+ ER+ breast cancer -0.19 2.1e-1 -0.125 3.0e-1 20 Click to see details
GSE19783 ER- ER- breast cancer 0.073 2.6e-1 0.049 3.3e-1 79 Click to see details
GSE38226 Liver fibrosis 0.128 2.9e-1 -0.001 5.0e-1 21 Click to see details
GSE32688 Pancreatic cancer 0.071 3.5e-1 0.141 2.2e-1 32 Click to see details
GSE26953 Aortic valvular endothelial cells -0.083 3.5e-1 -0.063 3.8e-1 24 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.044 4.2e-1 0.175 2.0e-1 25 Click to see details
GSE21849 B cell lymphoma 0.032 4.3e-1 0.244 1.0e-1 29 Click to see details
GSE19536 Breast cancer 0.011 4.6e-1 0.021 4.2e-1 100 Click to see details
GSE42095 Differentiated embryonic stem cells -0.002 5.0e-1 0.093 3.4e-1 23 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
PRAD 0.337 0.01 0.286 0.02 50 Click to see details
ESCA -0.622 0.02 -0.627 0.02 11 Click to see details
BLCA 0.431 0.04 0.406 0.05 18 Click to see details
CHOL -0.573 0.05 -0.450 0.11 9 Click to see details
BRCA 0.113 0.15 0.127 0.12 84 Click to see details
HNSC 0.098 0.27 0.077 0.31 42 Click to see details
THCA -0.078 0.28 -0.113 0.2 59 Click to see details
PAAD -0.442 0.28 -0.600 0.2 4 Click to see details
KIRP -0.098 0.3 -0.085 0.32 32 Click to see details
LIHC 0.078 0.3 0.011 0.47 49 Click to see details
UCEC -0.128 0.3 -0.118 0.32 19 Click to see details
COAD -0.293 0.32 0.000 0.5 5 Click to see details
STAD -0.081 0.33 -0.067 0.36 32 Click to see details
PCPG 0.429 0.36 0.500 0.33 3 Click to see details
KICH -0.069 0.37 -0.074 0.36 25 Click to see details
LUAD -0.1 0.38 -0.189 0.28 12 Click to see details
LUSC -0.047 0.39 -0.058 0.36 38 Click to see details
CESC -0.198 0.44 -0.500 0.33 3 Click to see details
KIRC 0.013 0.46 0.046 0.35 68 Click to see details
KIRC 0.013 0.46 0.046 0.35 68 Click to see details
KIRC 0.013 0.46 0.046 0.35 68 Click to see details
451 hsa-miR-424-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000653 CCNF cyclin F 2 1
MIRT000654 CDC14A cell division cycle 14A 2 1
MIRT000655 CDC25A cell division cycle 25A 4 3
MIRT000656 CHEK1 checkpoint kinase 1 5 4
MIRT000657 KIF23 kinesin family member 23 4 7
MIRT000658 ATF6 activating transcription factor 6 2 1
MIRT000659 WEE1 WEE1 G2 checkpoint kinase 6 7
MIRT000660 ANLN anillin actin binding protein 2 1
MIRT000696 PLAG1 PLAG1 zinc finger 6 10
MIRT000936 CCNE1 cyclin E1 6 7
MIRT000937 CCND3 cyclin D3 4 1
MIRT000938 CDK6 cyclin dependent kinase 6 6 3
MIRT000941 CCND1 cyclin D1 6 4
MIRT003225 ITPR1 inositol 1,4,5-trisphosphate receptor type 1 2 1
MIRT003226 MAP2K1 mitogen-activated protein kinase kinase 1 4 2
MIRT003227 PIAS1 protein inhibitor of activated STAT 1 2 1
MIRT003228 FGFR1 fibroblast growth factor receptor 1 5 3
MIRT003928 NFIA nuclear factor I A 3 2
MIRT005886 MYB MYB proto-oncogene, transcription factor 3 2
MIRT005887 SIAH1 siah E3 ubiquitin protein ligase 1 3 1
MIRT005926 HIF1A hypoxia inducible factor 1 alpha subunit 5 1
MIRT005927 CUL2 cullin 2 5 1
MIRT005928 SPI1 Spi-1 proto-oncogene 5 1
MIRT042434 CCIN calicin 1 1
MIRT042435 TTC39A tetratricopeptide repeat domain 39A 1 1
MIRT042436 TMF1 TATA element modulatory factor 1 1 1
MIRT042437 HIST1H2BK histone cluster 1 H2B family member k 1 1
MIRT042438 PNISR PNN interacting serine and arginine rich protein 2 3
MIRT042439 IARS isoleucyl-tRNA synthetase 1 1
MIRT042440 HIST2H2AA3 histone cluster 2 H2A family member a3 1 1
MIRT042441 YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta 2 3
MIRT042442 SMURF1 SMAD specific E3 ubiquitin protein ligase 1 1 1
MIRT042443 MAGED1 MAGE family member D1 1 1
MIRT042444 CNIH4 cornichon family AMPA receptor auxiliary protein 4 1 1
MIRT042445 ANKHD1 ankyrin repeat and KH domain containing 1 1 1
MIRT042446 EIF4G2 eukaryotic translation initiation factor 4 gamma 2 1 1
MIRT042447 BAZ2B bromodomain adjacent to zinc finger domain 2B 1 1
MIRT042448 APBB2 amyloid beta precursor protein binding family B member 2 1 1
MIRT042449 ANKRD17 ankyrin repeat domain 17 1 1
MIRT042450 RBM4B RNA binding motif protein 4B 1 1
MIRT042451 LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 1 1
MIRT042452 TRAP1 TNF receptor associated protein 1 1 1
MIRT042453 SCOC short coiled-coil protein 1 1
MIRT042454 SACS sacsin molecular chaperone 1 1
MIRT042455 IFIH1 interferon induced with helicase C domain 1 1 1
MIRT042456 TBPL1 TATA-box binding protein like 1 2 3
MIRT042457 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 1 1
MIRT042458 GTF2A1 general transcription factor IIA subunit 1 1 1
MIRT053106 FASN fatty acid synthase 4 5
MIRT053149 SOCS6 suppressor of cytokine signaling 6 2 1
MIRT053379 CDX2 caudal type homeobox 2 3 1
MIRT055427 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT055818 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT057518 CEP55 centrosomal protein 55 2 8
MIRT057737 ZDHHC16 zinc finger DHHC-type containing 16 2 2
MIRT061008 C1ORF21 chromosome 1 open reading frame 21 2 6
MIRT061250 AMOTL1 angiomotin like 1 2 12
MIRT064689 CCND2 cyclin D2 2 4
MIRT065719 TARBP2 TARBP2, RISC loading complex RNA binding subunit 2 4
MIRT066297 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT066316 USP15 ubiquitin specific peptidase 15 2 2
MIRT071212 FCF1 FCF1, rRNA-processing protein 2 2
MIRT072826 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 4
MIRT074534 PAGR1 PAXIP1 associated glutamate rich protein 1 2 4
MIRT075256 SNTB2 syntrophin beta 2 2 4
MIRT075278 VPS4A vacuolar protein sorting 4 homolog A 2 8
MIRT075897 C16ORF72 chromosome 16 open reading frame 72 2 6
MIRT076796 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT078287 RPS6KB1 ribosomal protein S6 kinase B1 2 2
MIRT079659 NAPG NSF attachment protein gamma 2 12
MIRT080016 GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 2 4
MIRT082989 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT083270 ZCCHC3 zinc finger CCHC-type containing 3 2 6
MIRT084466 SOWAHC sosondowah ankyrin repeat domain family member C 2 4
MIRT086013 UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2 2
MIRT087428 ZNRF3 zinc and ring finger 3 2 2
MIRT087559 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta 2 2
MIRT089112 B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2 4
MIRT089212 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT091674 RARB retinoic acid receptor beta 2 6
MIRT093688 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 6
MIRT096239 CANX calnexin 2 2
MIRT100211 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT100369 HSPA1B heat shock protein family A (Hsp70) member 1B 2 6
MIRT100572 PIM1 Pim-1 proto-oncogene, serine/threonine kinase 2 2
MIRT100741 VEGFA vascular endothelial growth factor A 2 12
MIRT100900 CD2AP CD2 associated protein 2 2
MIRT102441 CALU calumenin 2 2
MIRT102636 UBN2 ubinuclein 2 2 10
MIRT102974 EN2 engrailed homeobox 2 2 6
MIRT103097 MAFK MAF bZIP transcription factor K 2 4
MIRT103859 FOXK1 forkhead box K1 2 2
MIRT104020 USP42 ubiquitin specific peptidase 42 2 6
MIRT104236 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT106300 ZFHX4 zinc finger homeobox 4 2 6
MIRT106737 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT107222 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT107689 RECK reversion inducing cysteine rich protein with kazal motifs 2 2
MIRT109245 ZNF275 zinc finger protein 275 2 2
MIRT110057 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 5 7
MIRT112976 LUZP1 leucine zipper protein 1 2 6
MIRT114929 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT117660 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT120684 PAK2 p21 (RAC1) activated kinase 2 2 2
MIRT127740 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT133776 SKI SKI proto-oncogene 2 2
MIRT140152 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT142247 DCTN5 dynactin subunit 5 2 8
MIRT152287 TNFSF9 TNF superfamily member 9 2 2
MIRT154054 RASSF2 Ras association domain family member 2 2 2
MIRT156468 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT158533 TNRC6B trinucleotide repeat containing 6B 2 4
MIRT165183 GRAMD3 GRAM domain containing 2B 2 2
MIRT165904 CREBRF CREB3 regulatory factor 2 2
MIRT175237 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT179014 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT180914 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 8
MIRT186375 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT189764 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT189965 AGO4 argonaute 4, RISC catalytic component 2 2
MIRT190188 GPR180 G protein-coupled receptor 180 2 6
MIRT191460 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT191629 SLC39A9 solute carrier family 39 member 9 2 6
MIRT194242 FAM103A1 family with sequence similarity 103 member A1 2 6
MIRT194909 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT196457 TAOK1 TAO kinase 1 2 2
MIRT201460 SNRPB2 small nuclear ribonucleoprotein polypeptide B2 2 8
MIRT204597 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT204628 MOB4 MOB family member 4, phocein 2 8
MIRT204744 BZW1 basic leucine zipper and W2 domains 1 2 12
MIRT206023 NUP50 nucleoporin 50 2 6
MIRT211201 FGF2 fibroblast growth factor 2 5 5
MIRT211317 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 4
MIRT212611 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 8
MIRT223695 FZD6 frizzled class receptor 6 2 6
MIRT224969 BAG4 BCL2 associated athanogene 4 2 2
MIRT229350 ZNF449 zinc finger protein 449 2 2
MIRT229864 YIPF6 Yip1 domain family member 6 2 2
MIRT234346 MSL1 male specific lethal 1 homolog 2 8
MIRT247241 ELK4 ELK4, ETS transcription factor 2 4
MIRT247371 GABARAPL1 GABA type A receptor associated protein like 1 2 6
MIRT248769 ATXN7L3B ataxin 7 like 3B 2 4
MIRT249453 ZNF691 zinc finger protein 691 2 4
MIRT251497 DYNLL2 dynein light chain LC8-type 2 2 4
MIRT255339 SRPRB SRP receptor beta subunit 2 4
MIRT256311 CDC42SE2 CDC42 small effector 2 2 2
MIRT258414 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 2
MIRT265059 TBRG1 transforming growth factor beta regulator 1 2 2
MIRT267532 C1ORF226 chromosome 1 open reading frame 226 2 2
MIRT270556 SETD1B SET domain containing 1B 2 2
MIRT273669 HOXC8 homeobox C8 2 2
MIRT274745 RAB3IP RAB3A interacting protein 2 2
MIRT277509 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 4
MIRT282538 SLCO3A1 solute carrier organic anion transporter family member 3A1 2 2
MIRT289635 CBX2 chromobox 2 2 2
MIRT294287 ZFP28 ZFP28 zinc finger protein 2 2
MIRT295815 CHMP4B charged multivesicular body protein 4B 2 2
MIRT297782 GABPA GA binding protein transcription factor alpha subunit 2 4
MIRT300110 STRADB STE20-related kinase adaptor beta 2 2
MIRT300998 MTMR3 myotubularin related protein 3 2 2
MIRT302619 CRIM1 cysteine rich transmembrane BMP regulator 1 2 6
MIRT302829 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT307145 CTDSPL CTD small phosphatase like 2 4
MIRT313679 ITGA2 integrin subunit alpha 2 2 2
MIRT314055 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 2 8
MIRT317725 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT319335 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT320631 ZNRF2 zinc and ring finger 2 2 2
MIRT326306 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT327967 CHIC1 cysteine rich hydrophobic domain 1 2 6
MIRT367269 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT438750 PTCH1 patched 1 1 1
MIRT443811 SIDT2 SID1 transmembrane family member 2 2 2
MIRT446504 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT447774 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT448443 TLL1 tolloid like 1 2 2
MIRT449186 LUC7L3 LUC7 like 3 pre-mRNA splicing factor 2 2
MIRT451835 ALDH3B1 aldehyde dehydrogenase 3 family member B1 2 2
MIRT453284 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT453750 CSNK1E casein kinase 1 epsilon 2 2
MIRT454966 TPM2 tropomyosin 2 2 2
MIRT456863 ZNF460 zinc finger protein 460 2 10
MIRT460220 FGFR4 fibroblast growth factor receptor 4 2 2
MIRT460434 DOCK11 dedicator of cytokinesis 11 2 2
MIRT461560 ACTR3B ARP3 actin related protein 3 homolog B 2 2
MIRT463168 ZNF367 zinc finger protein 367 2 10
MIRT464666 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT464752 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT465167 TSC22D2 TSC22 domain family member 2 2 2
MIRT465566 TOB2 transducer of ERBB2, 2 2 2
MIRT465930 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT466009 TMEM189 transmembrane protein 189 2 8
MIRT466294 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT466433 TFAP2A transcription factor AP-2 alpha 2 8
MIRT466920 STK38 serine/threonine kinase 38 2 10
MIRT466998 SSRP1 structure specific recognition protein 1 2 4
MIRT468055 SIK1 salt inducible kinase 1 2 2
MIRT468147 SH3BP4 SH3 domain binding protein 4 2 2
MIRT468673 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT469086 RNF168 ring finger protein 168 2 2
MIRT469411 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT471035 PISD phosphatidylserine decarboxylase 2 10
MIRT471492 PDE4D phosphodiesterase 4D 2 4
MIRT471952 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT472269 NFIC nuclear factor I C 2 2
MIRT472661 NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 2 4
MIRT474314 LAMC1 laminin subunit gamma 1 2 2
MIRT474829 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT475065 IVNS1ABP influenza virus NS1A binding protein 2 6
MIRT475119 IPPK inositol-pentakisphosphate 2-kinase 2 2
MIRT475535 HOXA3 homeobox A3 4 8
MIRT475716 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT475841 HDGF heparin binding growth factor 2 4
MIRT476256 GNB1 G protein subunit beta 1 2 6
MIRT476273 GNAL G protein subunit alpha L 2 6
MIRT476696 FURIN furin, paired basic amino acid cleaving enzyme 2 2
MIRT477561 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 8
MIRT477845 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478908 CPSF7 cleavage and polyadenylation specific factor 7 2 6
MIRT479989 CARD10 caspase recruitment domain family member 10 2 2
MIRT481185 AVL9 AVL9 cell migration associated 2 6
MIRT482117 AKT3 AKT serine/threonine kinase 3 5 4
MIRT482373 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT482553 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 10
MIRT482578 ABHD2 abhydrolase domain containing 2 2 2
MIRT484774 ABCC6 ATP binding cassette subfamily C member 6 2 4
MIRT485216 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 8
MIRT487390 C10orf54 V-set immunoregulatory receptor 2 2
MIRT492711 PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2 2
MIRT494353 CASKIN1 CASK interacting protein 1 2 2
MIRT495143 ZNRF1 zinc and ring finger 1 2 2
MIRT496015 CD180 CD180 molecule 2 2
MIRT497772 KIAA0895 KIAA0895 2 2
MIRT498980 ORC4 origin recognition complex subunit 4 2 8
MIRT499452 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT499616 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 8
MIRT500093 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 8
MIRT500324 ZNF622 zinc finger protein 622 2 8
MIRT500422 ZMAT3 zinc finger matrin-type 3 2 4
MIRT500576 USP53 ubiquitin specific peptidase 53 2 2
MIRT500864 SYPL1 synaptophysin like 1 2 8
MIRT500935 SRPR SRP receptor alpha subunit 2 6
MIRT500949 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 2 8
MIRT501088 SMAD7 SMAD family member 7 5 9
MIRT501502 PRICKLE2 prickle planar cell polarity protein 2 2 2
MIRT502036 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT502148 KIF5B kinesin family member 5B 2 8
MIRT502498 FAM122B family with sequence similarity 122B 2 8
MIRT502571 E2F7 E2F transcription factor 7 2 10
MIRT502646 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT502919 CDCA4 cell division cycle associated 4 2 8
MIRT502948 CDC37L1 cell division cycle 37 like 1 2 8
MIRT503143 ATG9A autophagy related 9A 2 6
MIRT504334 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT504536 ZNF620 zinc finger protein 620 2 6
MIRT504852 HAUS3 HAUS augmin like complex subunit 3 2 6
MIRT505114 YTHDC1 YTH domain containing 1 2 6
MIRT505346 TMEM245 transmembrane protein 245 2 6
MIRT505396 TMEM100 transmembrane protein 100 2 2
MIRT505502 SRSF1 serine and arginine rich splicing factor 1 2 6
MIRT505546 SNX16 sorting nexin 16 2 6
MIRT505690 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT505908 RIMS3 regulating synaptic membrane exocytosis 3 2 6
MIRT505926 RCAN3 RCAN family member 3 2 4
MIRT506108 PPIG peptidylprolyl isomerase G 2 6
MIRT506139 PLRG1 pleiotropic regulator 1 2 4
MIRT506192 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 6
MIRT506486 MYO5A myosin VA 2 6
MIRT506999 HNRNPDL heterogeneous nuclear ribonucleoprotein D like 2 6
MIRT507819 CDK1 cyclin dependent kinase 1 2 6
MIRT507850 CCNE2 cyclin E2 2 6
MIRT507882 CBX6 chromobox 6 2 2
MIRT508036 AXIN2 axin 2 2 6
MIRT508641 CASK calcium/calmodulin dependent serine protein kinase 2 5
MIRT509364 DMPK DM1 protein kinase 2 11
MIRT509690 ATAD5 ATPase family, AAA domain containing 5 2 4
MIRT510043 AKR1B10 aldo-keto reductase family 1 member B10 2 4
MIRT511845 GPATCH8 G-patch domain containing 8 2 4
MIRT512285 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT512642 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 4
MIRT513856 JARID2 jumonji and AT-rich interaction domain containing 2 2 8
MIRT514022 CAMSAP1 calmodulin regulated spectrin associated protein 1 2 4
MIRT514043 ATG14 autophagy related 14 2 2
MIRT518091 TRIM35 tripartite motif containing 35 2 2
MIRT518530 FLCN folliculin 2 6
MIRT518994 NNT nicotinamide nucleotide transhydrogenase 2 4
MIRT521056 SLC2A3 solute carrier family 2 member 3 2 4
MIRT521203 SBNO1 strawberry notch homolog 1 2 6
MIRT521814 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT522100 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT522775 LAMP2 lysosomal associated membrane protein 2 2 6
MIRT537817 EFNB2 ephrin B2 2 4
MIRT539899 RPL14 ribosomal protein L14 2 4
MIRT540843 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541216 HOXA10 homeobox A10 2 2
MIRT541434 CBX4 chromobox 4 2 2
MIRT542808 PHC3 polyhomeotic homolog 3 2 2
MIRT542836 PDCD1 programmed cell death 1 2 7
MIRT543059 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT543079 APP amyloid beta precursor protein 2 2
MIRT543306 ZNF585B zinc finger protein 585B 2 2
MIRT543408 ANAPC13 anaphase promoting complex subunit 13 2 2
MIRT543525 PRSS21 protease, serine 21 2 2
MIRT543797 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 4
MIRT543835 GSG1 germ cell associated 1 2 2
MIRT544571 POLDIP3 DNA polymerase delta interacting protein 3 2 2
MIRT544589 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT544912 CLSPN claspin 2 2
MIRT544965 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT545186 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 4
MIRT545347 CCDC83 coiled-coil domain containing 83 2 2
MIRT545682 DECR1 2,4-dienoyl-CoA reductase 1 2 2
MIRT545959 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT546114 USP48 ubiquitin specific peptidase 48 2 4
MIRT546610 SALL1 spalt like transcription factor 1 2 4
MIRT546623 RUNX1T1 RUNX1 translocation partner 1 2 2
MIRT546639 RTN4 reticulon 4 2 2
MIRT547132 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT547234 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2 4
MIRT547306 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 2 2
MIRT547411 MKX mohawk homeobox 2 2
MIRT547462 MBD4 methyl-CpG binding domain 4, DNA glycosylase 2 2
MIRT547549 LRRFIP2 LRR binding FLII interacting protein 2 2 4
MIRT547663 KPNA3 karyopherin subunit alpha 3 2 2
MIRT547700 KPNA1 karyopherin subunit alpha 1 2 4
MIRT547970 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT547996 HCFC2 host cell factor C2 2 4
MIRT548015 GRB2 growth factor receptor bound protein 2 2 4
MIRT548223 FKBP1A FK506 binding protein 1A 2 2
MIRT548273 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT548729 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT548806 CLIP4 CAP-Gly domain containing linker protein family member 4 2 4
MIRT548949 CDK17 cyclin dependent kinase 17 2 2
MIRT549074 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT549121 C11orf24 chromosome 11 open reading frame 24 2 4
MIRT549276 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT549390 AMOT angiomotin 2 2
MIRT550402 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 2 4
MIRT550466 OSCAR osteoclast associated, immunoglobulin-like receptor 2 4
MIRT550615 MTHFR methylenetetrahydrofolate reductase 2 2
MIRT550823 FAM229B family with sequence similarity 229 member B 2 2
MIRT551379 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT551617 ZNF267 zinc finger protein 267 2 2
MIRT551737 SSU72 SSU72 homolog, RNA polymerase II CTD phosphatase 2 2
MIRT552035 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT552344 ZNF704 zinc finger protein 704 2 2
MIRT552749 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT553439 TPM3 tropomyosin 3 2 2
MIRT553561 TMEM161B transmembrane protein 161B 2 2
MIRT553618 TM7SF3 transmembrane 7 superfamily member 3 2 2
MIRT553772 TAF13 TATA-box binding protein associated factor 13 2 4
MIRT553809 SZRD1 SUZ RNA binding domain containing 1 2 4
MIRT554700 RNF149 ring finger protein 149 2 2
MIRT554962 RACGAP1 Rac GTPase activating protein 1 2 2
MIRT555032 RAB23 RAB23, member RAS oncogene family 2 2
MIRT555142 PTPRD protein tyrosine phosphatase, receptor type D 2 2
MIRT555225 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 4
MIRT555275 PRDM4 PR/SET domain 4 2 2
MIRT555432 PPAP2B phospholipid phosphatase 3 2 2
MIRT556387 LURAP1L leucine rich adaptor protein 1 like 2 2
MIRT556855 KANK1 KN motif and ankyrin repeat domains 1 2 4
MIRT557281 HIST2H2BE histone cluster 2 H2B family member e 2 2
MIRT557480 GPR27 G protein-coupled receptor 27 2 4
MIRT558037 EXT1 exostosin glycosyltransferase 1 2 2
MIRT558507 CYP26B1 cytochrome P450 family 26 subfamily B member 1 2 4
MIRT558589 CREBL2 cAMP responsive element binding protein like 2 2 4
MIRT558662 CNKSR3 CNKSR family member 3 2 2
MIRT559011 CA8 carbonic anhydrase 8 2 2
MIRT559158 BTN3A3 butyrophilin subfamily 3 member A3 2 2
MIRT559531 ARHGAP12 Rho GTPase activating protein 12 2 4
MIRT560852 OSBPL3 oxysterol binding protein like 3 2 2
MIRT561149 KRT33B keratin 33B 2 2
MIRT561400 TUBB2A tubulin beta 2A class IIa 2 2
MIRT561874 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT562027 LANCL1 LanC like 1 2 2
MIRT562201 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT562877 KIAA1456 KIAA1456 2 2
MIRT563086 SLC25A12 solute carrier family 25 member 12 2 2
MIRT563503 DLGAP3 DLG associated protein 3 2 2
MIRT563701 THRAP3 thyroid hormone receptor associated protein 3 2 2
MIRT563845 SMDT1 single-pass membrane protein with aspartate rich tail 1 2 2
MIRT563896 RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2 2
MIRT564332 CCNT1 cyclin T1 2 2
MIRT564478 ZNF391 zinc finger protein 391 2 2
MIRT564552 CCDC80 coiled-coil domain containing 80 2 2
MIRT564836 ZBTB16 zinc finger and BTB domain containing 16 2 2
MIRT564950 XKR7 XK related 7 2 2
MIRT564989 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT565044 VAV2 vav guanine nucleotide exchange factor 2 2 2
MIRT565401 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT566120 RASEF RAS and EF-hand domain containing 2 2
MIRT566650 NCKAP1 NCK associated protein 1 2 2
MIRT566831 MAP3K7 mitogen-activated protein kinase kinase kinase 7 2 2
MIRT567021 KLHL15 kelch like family member 15 2 2
MIRT567446 GNG12 G protein subunit gamma 12 2 2
MIRT567477 FZD9 frizzled class receptor 9 2 2
MIRT568021 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT568142 CCDC88C coiled-coil domain containing 88C 2 2
MIRT568474 ARMC12 armadillo repeat containing 12 2 2
MIRT568574 AHNAK2 AHNAK nucleoprotein 2 2 2
MIRT568625 ACVR2A activin A receptor type 2A 5 3
MIRT570466 TLK1 tousled like kinase 1 2 2
MIRT571119 UBE2H ubiquitin conjugating enzyme E2 H 2 2
MIRT571283 TTLL5 tubulin tyrosine ligase like 5 2 2
MIRT571428 RIF1 replication timing regulatory factor 1 2 2
MIRT571660 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT571828 PHF19 PHD finger protein 19 2 2
MIRT571928 LSM11 LSM11, U7 small nuclear RNA associated 2 2
MIRT574057 PROSC pyridoxal phosphate binding protein 2 2
MIRT574202 CLEC2D C-type lectin domain family 2 member D 2 2
MIRT574539 PDIA6 protein disulfide isomerase family A member 6 2 4
MIRT574594 N4BP1 NEDD4 binding protein 1 2 2
MIRT575882 Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2 4
MIRT575924 Dmpk dystrophia myotonica-protein kinase 2 7
MIRT576099 Pdcd1 programmed cell death 1 2 5
MIRT576591 Npepps aminopeptidase puromycin sensitive 2 2
MIRT614698 TRAK1 trafficking kinesin protein 1 2 2
MIRT616467 ADRA2B adrenoceptor alpha 2B 2 2
MIRT618896 ANKMY1 ankyrin repeat and MYND domain containing 1 2 2
MIRT621498 GPRC5A G protein-coupled receptor class C group 5 member A 2 4
MIRT640538 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT645510 BSPRY B-box and SPRY domain containing 2 2
MIRT646595 ANKRD36 ankyrin repeat domain 36 2 2
MIRT648784 KLHL40 kelch like family member 40 2 2
MIRT655812 NOTCH2 notch 2 2 2
MIRT658793 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT659256 CUL3 cullin 3 2 2
MIRT680982 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682285 RS1 retinoschisin 1 2 2
MIRT682514 GLP2R glucagon like peptide 2 receptor 2 2
MIRT691709 FLOT2 flotillin 2 2 2
MIRT693930 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT701506 NEGR1 neuronal growth regulator 1 2 2
MIRT702092 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT702877 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT713419 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT714438 ARHGAP32 Rho GTPase activating protein 32 2 2
MIRT716432 RAB15 RAB15, member RAS oncogene family 2 2
MIRT717461 ADORA3 adenosine A3 receptor 2 2
MIRT720149 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT725132 SYNRG synergin gamma 2 2
MIRT731524 SOCS2 suppressor of cytokine signaling 2 1 1
MIRT731954 KDM5B lysine demethylase 5B 1 1
MIRT732455 LINC00922 long intergenic non-protein coding RNA 922 2 0
MIRT734001 BFAR bifunctional apoptosis regulator 3 0
MIRT734203 APLNR apelin receptor 3 0
MIRT734275 APLN apelin 3 0
MIRT735229 KCNQ1OT1 KCNQ1 opposite strand/antisense transcript 1 (non-protein coding) 0 0
MIRT737161 LINC00324 long intergenic non-protein coding RNA 324 1 0
MIRT737429 CADM1 cell adhesion molecule 1 2 0
MIRT756449 NUAK1 NUAK family kinase 1 1 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-424 Tamoxifen approved 2733526 Microarray rat liver 17343880 2007 up-regulated
miR-424 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miR-424 Medpor NULL NULL Microarray osteoblast-like cells line (MG-63) 18408260 2008 up-regulated
miR-424 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
miR-424 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-424 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer SKBR3 22076154 2011 up-regulated
miR-424 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-424 Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 down-regulated
miR-424 Bicalutamide approved 2375 Microarray prostate 22674191 2012 up-regulated
miR-424 Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-424 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (BGC823)
hsa-mir-424 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC-7901)
hsa-mir-424 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-424 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer tissue
hsa-mir-424 Fluorouracil 3385 NSC19893 approved sensitive High Gastric Cancer tissue
hsa-mir-424 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-424 Methotrexate 126941 NSC740 approved resistant cell line (W1)
hsa-mir-424 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-424 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-424 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-424 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-424 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-424 Cisplatin 5460033 NSC119875 approved sensitive cell line (SGC-7901)
hsa-mir-424 Cisplatin 5460033 NSC119875 approved sensitive cell line (BGC-823)
hsa-miR-424-5p (-)-huprine y 54608866 NSC720262 resistant
hsa-miR-424-5p (-)7,8-dihydrocalanolide a 383107 NSC682400 sensitive
hsa-miR-424-5p (3e)-3-[(2,6-dimethylimidazo[2,1-b][1,3]thiazol-5-yl)methylidene]-1-methylindol-2-one 24205817 NSC736793 resistant
hsa-miR-424-5p (3e)-3-[(2,6-dimethylimidazo[2,1-b][1,3]thiazol-5-yl)methylidene]-1h-indol-2-one 5471419 NSC711074 resistant
hsa-miR-424-5p (3z,5z)-3,5-bis[(4-fluorophenyl)methylidene]-1,1-dimethylpiperidin-1-ium-4-one;iodide 54608810 NSC634794 sensitive
hsa-miR-424-5p (4E)-2-(2-hydroxybenzoyl)-5-methyl-4-[(4-nitrophenyl)methylidene]pyrazol-3-one 5467414 NSC652175 sensitive
hsa-miR-424-5p (5R,5aS)-5-[2-(dimethylamino)ethoxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one;hydrochloride 371049 NSC644945 sensitive
hsa-miR-424-5p (5s,5as)-5-[3-(dimethylamino)propylamino]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one 375034 NSC653860 sensitive
hsa-miR-424-5p (E)-3-[2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl]-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 54613570 NSC750335 resistant
hsa-miR-424-5p (E)-but-2-enedioic acid;2-[4-tert-butyl-1-[(4-fluorophenyl)methyl]cyclohexyl]oxy-N,N-dimethylethanamine 5351427 NSC670226 resistant
hsa-miR-424-5p (z)-3-iodo-1,2-diphenyl-2-propen-1-one 5468683 NSC674454 resistant
hsa-miR-424-5p [1-[(2-bromo-5-hydroxy-4-methoxyphenyl)methyl]spiro[1,3,4,5,7,8-hexahydroisoquinoline-6,2'-1,3-dioxolane]-2-yl]-cyclobutylmethanone 401792 NSC715522 resistant
hsa-miR-424-5p [2-[[3-(3-aminopropoxy)naphthalene-2-carbonyl]amino]-5-chlorophenyl] 3-(3-aminopropoxy)naphthalene-2-carboxylate;hydrochloride 54613723 NSC751300 resistant
hsa-miR-424-5p [4-fluoro-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-2-(hydroxymethyl)oxolan-3-yl] butanoate 380992 NSC666869 sensitive
hsa-miR-424-5p 1-(2-hydroxybenzoyl)-3-methyl-4-(4-methoxybenzylidene)-1h-pyrazole-5(4h)-one 5351408 NSC652174 sensitive
hsa-miR-424-5p 1-(5,8-dimethyl-6-nitro-9h-carbazol-3-yl)ethanone hydrazone 6078917 NSC652561 sensitive
hsa-miR-424-5p 1-[(2S)-3-[[2,7-di(piperidin-1-yl)-2,3,4a,5,7,7a-hexahydrofuro[3,4-b][1,4]dioxin-3-yl]oxy]oxolan-2-yl]piperidine 253322 NSC76150 sensitive
hsa-miR-424-5p 1-[(z)-(5-chloro-2-hydroxyphenyl)methylideneamino]-3-[(e)-(5-chloro-2-hydroxyphenyl)methylideneamino]urea 135408530 NSC48238 resistant
hsa-miR-424-5p 1-[5-[(e)-2-[4-(dimethylamino)phenyl]ethenyl]-6-methyl-1,2,4-triazin-3-yl]-6-hydroxy-3-phenyl-2-sulfanylidenepyrimidin-4-one 6412312 NSC698031 resistant
hsa-miR-424-5p 1-[8-(3-methoxyphenyl)-6,7-dimethyl-7,8-dihydro-6h-[1,3]dioxolo[4,5-g]chromen-6-yl]pyrrolidine 382365 NSC669884 resistant
hsa-miR-424-5p 10,11-methylenedioxycamptothecin 72403 NSC634724 sensitive
hsa-miR-424-5p 15-[2-(dimethylamino)ethyl]-10-[2-(2-hydroxyethylamino)ethylamino]-1,15-diazatetracyclo[7.7.1.02,7.013,17]heptadeca-2,4,6,9,11,13(17)-hexaene-8,14,16-trione;hydrochloride 392057 NSC691849 sensitive
hsa-miR-424-5p 15-[2-(dimethylamino)ethyl]-10-[2-(dimethylamino)ethyl-methylamino]-1,15-diazatetracyclo[7.7.1.02,7.013,17]heptadeca-2,4,6,9,11,13(17)-hexaene-8,14,16-trione 392571 NSC693118 sensitive
hsa-miR-424-5p 2-(2-ethyl-6-propan-2-ylanilino)-3-(4-methylpyridin-1-ium-1-yl)naphthalene-1,4-dione;perchlorate 24202023 NSC618659 sensitive
hsa-miR-424-5p 2-(dipentylamino)-1-(1,2,3,4-tetrahydrophenanthren-9-yl)ethanol;hydrochloride 24181846 NSC62485 resistant
hsa-miR-424-5p 2-[[1-(chloromethoxy)-2-(dimethylamino)ethyl]amino]-n-[2-[[4-[2-[[2-[[1-(chloromethoxy)-2-(dimethylamino)ethyl]amino]-2-(sulfanylmethylamino)acetyl]amino]ethylamino]-5,8-dihydroxy-9,10-dioxoanthracen- 438971 NSC692228 sensitive
hsa-miR-424-5p 2-[[4-[(2-amino-4-oxo-3H-quinazolin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acid 135402053 NSC327182 sensitive
hsa-miR-424-5p 2-[16-(3,4-dimethoxyphenyl)-12,14-diphenyl-10-oxa-3,5,6,8,12,13-hexazatetracyclo[7.7.0.02,6.011,15]hexadeca-1(9),2,4,7,11(15),13-hexaen-4-yl]acetonitrile 391834 NSC691421 sensitive
hsa-miR-424-5p 2-[2-[5-(ethoxycarbonylcarbamoyl)-3-methyl-2,4-dioxopyrimidin-1-yl]ethylsulfanyl]ethyl n-[6-[2-[2-[5-(ethoxycarbonylcarbamoyl)-3-methyl-2,4-dioxopyrimidin-1-yl]ethylsulfanyl]ethoxycarbonylamino]hexyl] 367630 NSC637505 sensitive
hsa-miR-424-5p 2-[3-[1-(4-chlorophenyl)-1-methyl-3-oxo-isoindolin-2-yl]propyl]isoindoline-1,3-dione 395648 NSC700430 resistant
hsa-miR-424-5p 2-amino-6-(benzylamino)-4-(2-chlorophenyl)pyridine-3,5-dicarbonitrile 24205132 NSC734396 sensitive
hsa-miR-424-5p 2-bromo-4-(5-fluoro-1,3-benzothiazol-2-yl)aniline 399248 NSC709925 resistant
hsa-miR-424-5p 2-chloro-3-phenoxy-1,4-naphthoquinone NSC1507 resistant
hsa-miR-424-5p 2-hydroxy-3-[(8-hydroxyquinolin-7-yl)-(4-methoxyphenyl)methyl]-6-propan-2-ylcyclohepta-2,4,6-trien-1-one 361375 NSC624401 sensitive
hsa-miR-424-5p 2-methoxy-5,7,8,13,13a,14-hexahydroisoquino[3,2-b][3]benzazepine 392606 NSC693146 resistant
hsa-miR-424-5p 2-phenyl-3a,3b,4,5,6,7,8,8a,13,13b-decahydro-1h-cyclohepta[c]pyrrolo[3,4-a]carbazole-1,3(2h)-dione 362439 NSC626388 sensitive
hsa-miR-424-5p 2-thienyl-[3-(thiophene-2-carbonyl)-2-thioxo-imidazolidin-1-yl]methanone 396758 NSC703468 sensitive
hsa-miR-424-5p 2,2,2-trifluoro-N-[3-[naphthalen-2-ylmethyl-[4-[naphthalen-2-ylmethyl-[3-[(2,2,2-trifluoroacetyl)amino]propyl]amino]butyl]amino]propyl]acetamide 389638 NSC685981 resistant
hsa-miR-424-5p 2,4-quinazolinediamine, 6,6'-thiobis- 393413 NSC695267 sensitive
hsa-miR-424-5p 2,5,11-trimethyl-9-phenoxy-6h-pyrido[4,3-b]carbazol-2-ium;acetate 10431819 NSC650269 sensitive
hsa-miR-424-5p 20-[3-(1,4-diazepan-1-yl)propyl]-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dione;hydrochloride 45027855 NSC728319 sensitive
hsa-miR-424-5p 3-[(4-chlorophenyl)methyl]-4-[(e)-(3-methoxyphenyl)methylideneamino]-1h-1,2,4-triazol-5-one 9556356 NSC698065 sensitive
hsa-miR-424-5p 3-[(e)-carbazol-9-yliminomethyl]-4-hydroxy-5-methoxybenzaldehyde 135436314 NSC718153 sensitive
hsa-miR-424-5p 3-amino-N-(4-benzylphenyl)-5-chloroindazole-1-carboxamide 51033073 NSC749550 resistant
hsa-miR-424-5p 4'-(9-acridinylamino)sulfanilanilide, monohydrochloride 148802 NSC140701 sensitive
hsa-miR-424-5p 4-(2-azidophenothiazin-10-yl)-N,N-dimethylbutan-1-amine;oxalic acid 385933 NSC677395 resistant
hsa-miR-424-5p 4-[(1-benzyl-4-chloro-2,5-dioxopyrrol-3-yl)amino]-N-(4-fluorophenyl)benzamide 1194957 NSC732830 sensitive
hsa-miR-424-5p 4-[[3-[(4-carbamimidoylphenoxy)methyl]phenyl]methoxy]benzenecarboximidamide;hydrochloride 24203365 NSC727667 sensitive
hsa-miR-424-5p 4-[6-[4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1-yl)phenyl]hexyl]benzenesulfonyl fluoride;ethanesulfonic acid 280526 NSC132279 sensitive
hsa-miR-424-5p 4-amino-8-chloro-2-(4-methoxyphenyl)iminopyrimido[2,1-b][1,3]benzothiazole-3-carbonitrile 45029232 NSC745677 resistant
hsa-miR-424-5p 4-n-(7-chloro-3-phenylquinolin-4-yl)-1-n,1-n-diethylpentane-1,4-diamine;hydroiodide 24182056 NSC13477 resistant
hsa-miR-424-5p 4-n-(7-chloroquinolin-4-yl)-1-n-cyclohexylcyclohexane-1,4-diamine NSC3618 resistant
hsa-miR-424-5p 5-(3-phenyl-3-oxo-1-propynyl)pyrimidine-2,4(1h,3h)-dione 359098 NSC619674 sensitive
hsa-miR-424-5p 5-(4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-4,5-dihydro-1h-pyrazole 49865894 NSC748404 resistant
hsa-miR-424-5p 5-[(E)-2-(5-ethyl-1-methylpyridin-1-ium-2-yl)ethenyl]quinolin-8-ol;iodide 135534376 NSC79543 sensitive
hsa-miR-424-5p 5-amino-2-(4-chloroanilino)-1,3-thiazole-4-carbonitrile 367981 NSC638199 sensitive
hsa-miR-424-5p 5-phenyl-2,3-bis(2-thienyl)thiophene 395510 NSC700200 resistant
hsa-miR-424-5p 6-[2-[2-[2-[2-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)ethylamino]ethylamino]ethylamino]ethyl]indeno[1,2-c]isoquinoline-5,11-dione;2,2,2-trifluoroacetic acid 45027880 NSC730870 sensitive
hsa-miR-424-5p 6-[2-[3-[2-(5,11-dioxoindeno[1,2-c]isoquinolin-6-yl)ethylamino]propylamino]ethyl]indeno[1,2-c]isoquinoline-5,11-dione;2,2,2-trifluoroacetic acid 45027847 NSC728087 sensitive
hsa-miR-424-5p 6-[3-[(4-fluorophenyl)methoxy]phenyl]-5-(2-methylsulfonylpyrimidin-4-yl)imidazo[2,1-b][1,3]thiazole 155811287 NSC763232 resistant
hsa-miR-424-5p 6-chloro-1-[2-[ethyl-(2-hydroxy-2-methylpropyl)amino]ethylamino]-4-methylthioxanthen-9-one;hydrochloride 24182355 NSC15795 resistant
hsa-miR-424-5p 6-chloro-9-[4-(4-methylphenoxy)-5-[(4-methylphenoxy)methyl]oxolan-2-yl]purine 389530 NSC685827 resistant
hsa-miR-424-5p 7-phenyl-5h-pyrazolo[3,4-e][1,2,4]triazin-3-ylamine 6399307 NSC629487 sensitive
hsa-miR-424-5p 7h-5,6-dithioleno[4,3-d]uracil 388876 NSC684074 sensitive
hsa-miR-424-5p 9,10-anthracenedione, 1-[(oxiranylmethyl)amino]- 384119 NSC673348 sensitive
hsa-miR-424-5p 9.beta.-d-arabinofuranosyl-2-chloroadenine 235481 NSC76356 sensitive
hsa-miR-424-5p Acetylmarinobufogenin 282302 NSC135687 sensitive
hsa-miR-424-5p Aclarubicin 308141 NSC208734 sensitive
hsa-miR-424-5p Acovenoside b 272418 NSC116789 sensitive
hsa-miR-424-5p Anthraquinone, 1-hydroxy-4-[p-(2-hydroxyethyl)anilino]- 291365 NSC156565 resistant
hsa-miR-424-5p Arq monoacetate 385441 NSC676676 sensitive
hsa-miR-424-5p Azane;dichloroplatinum;2-(3,4-dimethoxyphenyl)ethanamine 498557 NSC631304 sensitive
hsa-miR-424-5p Azq 42616 NSC182986 sensitive
hsa-miR-424-5p Bafilomycin deriv 5385089 NSC381866 resistant
hsa-miR-424-5p Benzene, 1,1'-(1,2-ethanediyl)bis[2,5-dimethoxy- 297389 NSC168516 resistant
hsa-miR-424-5p Betuletol 5459196 NSC641548 sensitive
hsa-miR-424-5p Bialamicol 10304 NSC6386 resistant
hsa-miR-424-5p Biantrazole 54607781 NSC357885 sensitive
hsa-miR-424-5p Bn-2629 393111 NSC694501 sensitive
hsa-miR-424-5p Calactin 30100 NSC650471 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-424-5p Camptothecin 24360 NSC94600 sensitive
hsa-miR-424-5p Camptothecin 24360 NSC94600 sensitive
hsa-miR-424-5p Cardenolide 2 388098 NSC682561 sensitive
hsa-miR-424-5p Ci-921: amsacrine derivative 157348 NSC343499 sensitive
hsa-miR-424-5p Cladribine 1546 NSC105014 sensitive
hsa-miR-424-5p Digitoxigenin glycoside NSC267713 sensitive
hsa-miR-424-5p Digoxin 2724385 NSC95100 approved sensitive
hsa-miR-424-5p Dimethyl (Z)-2-(2,3,4,6,8-pentamethylazulen-1-yl)but-2-enedioate 5468314 NSC668419 resistant
hsa-miR-424-5p Echujetin 274159 NSC407806 sensitive
hsa-miR-424-5p Fagaronine chloride 40304 NSC157995 sensitive
hsa-miR-424-5p Faradiol 397486 NSC705534 sensitive
hsa-miR-424-5p Ferric-taxol 54612932 NSC749908 resistant
hsa-miR-424-5p Fludarabine 657237 NSC118218 approved sensitive
hsa-miR-424-5p Gnmlngdfmleynr-uhfffaoysa-n 402862 NSC717147 resistant
hsa-miR-424-5p Gw876790x 25023715 NSC756413 resistant
hsa-miR-424-5p Homohalichondrin b 6711269 NSC609394 resistant
hsa-miR-424-5p Hopeaphenol 495605 NSC661748 resistant
hsa-miR-424-5p Irinotecan 60838 NSC728073 approved sensitive
hsa-miR-424-5p Irinotecan 60838 NSC728073 approved sensitive
hsa-miR-424-5p Isopinnatal 390665 NSC688277 sensitive
hsa-miR-424-5p Lmp-400 11533060 NSC724998 sensitive
hsa-miR-424-5p Lunatin 5351204 NSC89671 resistant
hsa-miR-424-5p M-amsa 148674 NSC154948 sensitive
hsa-miR-424-5p Melphalan 460612 NSC8806 approved sensitive
hsa-miR-424-5p Merophan 9571 NSC57199 sensitive
hsa-miR-424-5p Methyl (2s)-2-[[4-[[[(e)-2-methyl-3-phenylprop-2-enoyl]amino]methyl]benzoyl]amino]-4-methylsulfanylbutanoate 5470461 NSC702106 resistant
hsa-miR-424-5p Mitoxantrone 4212 NSC279836 approved sensitive
hsa-miR-424-5p Mitoxantrone 4212 NSC279836 approved sensitive
hsa-miR-424-5p N-((3-benzoyl-2-thioxo-1-imidazolidinyl)carbothioyl)-n-phenylbenzamide 396960 NSC704180 sensitive
hsa-miR-424-5p N-(3,5-dimethoxybenzyl)-4-methoxyaniline 364713 NSC631371 resistant
hsa-miR-424-5p N-[(5s,8ar,9r)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[5,6-f][1,3]benzodioxol-5-yl]-3-cyanobenzamide 369926 NSC642293 sensitive
hsa-miR-424-5p N-[4-[[[2-(4-chloroanilino)pyridine-3-carbonyl]amino]sulfamoyl]phenyl]acetamide 16126694 NSC737147 resistant
hsa-miR-424-5p N-[bis(aziridin-1-yl)phosphoryl]adamantan-1-amine 64376 NSC166199 sensitive
hsa-miR-424-5p N,n-bis{[(4-chlorophenyl)sulfanyl]methyl}-4-methylaniline 248767 NSC66211 sensitive
hsa-miR-424-5p Navan 941650 NSC108165 resistant
hsa-miR-424-5p Ncs-665564 380161 NSC665564 sensitive
hsa-miR-424-5p Neriifolin 276293 NSC123976 sensitive
hsa-miR-424-5p NSC623283 NSC623283 sensitive
hsa-miR-424-5p NSC763857 NSC763857 resistant
hsa-miR-424-5p Oxanthrazole 59916 NSC349174 sensitive
hsa-miR-424-5p Pcnu 26328 NSC95466 sensitive
hsa-miR-424-5p Phenylbenzophenone 407452 NSC5639 resistant
hsa-miR-424-5p S-(6-oxo-1,3,5-triphenyl-2-thioxo-1,2,3,6-tetrahydro-4-pyrimidinyl) 4-methoxybenzenecarbothioate 383063 NSC671107 sensitive
hsa-miR-424-5p S-(dimethylarsino)-3-mercapto-1,2-propanediol 406475 NSC724596 sensitive
hsa-miR-424-5p Stk716556 342450 NSC379399 resistant
hsa-miR-424-5p Tamoxifen 2733525 NSC180973 approved resistant
hsa-miR-424-5p Tetramethyl (1R,5R,6S,9S)-3-(4-chlorobenzoyl)oxy-5-hydroxy-7-[2-(trifluoromethyl)phenyl]bicyclo[3.3.1]non-2-ene-2,4,6,9-tetracarboxylate 24204894 NSC733348 sensitive
hsa-miR-424-5p Thevetin 5458241 NSC123979 sensitive
hsa-miR-424-5p Toddalin 5351594 NSC76023 resistant
hsa-miR-424-5p Topotecan 60699 NSC609699 approved sensitive
hsa-miR-424-5p Topotecan 60699 NSC609699 approved sensitive
hsa-miR-424-5p Venenatine 272417 NSC116787 sensitive
hsa-miR-424-5p Yoshi 864 18949 NSC102627 sensitive
hsa-miR-424-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-424-5p Docetaxel 148124 NSC628503 approved resistant High Non-Small Cell Lung Cancer cell line (SPC-A1)
hsa-miR-424-5p Doxorubicin 31703 NSC123127 approved resistant High Leukemia cell line (K562)
hsa-miR-424-5p 10-Hydroxycamptothecin 97226 NSC107124 sensitive High Gastric Cancer cell line (BGC823, SGC-7901, MGC-803, HGC-27, NCI-N87, AGS)
hsa-miR-424-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SUIT-2, CAPAN-1)
hsa-miR-424-5p Cisplatin 5460033 NSC119875 approved sensitive High Germ Cell Tumor cell line (NTERA-2)
hsa-miR-424-5p Cisplatin 5460033 NSC119875 approved sensitive Low Epidermoid Carcinoma cell line (KB-3-1, KB-CP.5, KB-CP20)
hsa-miR-424-5p Chemotherapy sensitive High Epithelial Ovarian Cancer tissue
hsa-miR-424-5p Etoposide 36462 NSC141540 approved resistant Low melanoma tissue and cell line (A375)
hsa-miR-424-5p Doxorubicin 31703 NSC123127 approved resistant Low Colorectal Cancer tissue and cell line (HCT-116)
hsa-miR-424-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-424-5p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-424-5p Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-424-5p Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-424-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-424-5p Vincristine 5978 approved sensitive High Colorectal Cancer cell line (HCT-8)
hsa-miR-424-5p Gefitinib 123631 NSC715055 approved sensitive High Lung Adenocarcinoma cell line (A549)
hsa-miR-424-5p Doxorubicin 31703 NSC123127 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-424-5p Docetaxel 148124 NSC628503 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-424-5p Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-424-5p Imatinib 5291 NSC743414 approved sensitive Low Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-424-5p Taxane 9548828 resistant High Prostate Cancer cell line (PC-3, PR20
hsa-miR-424-5p Plx-4720 24180719 NSC757438 sensitive High Thyroid Cancer cell line (8505c, BCPAP)
hsa-miR-424-5p Cisplatin 5460033 NSC119875 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-424-5p Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-424-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7, PLC)
hsa-miR-424-5p Trail sensitive Low Acute Myeloid Leukemia tissue and cell line (HL-60, K562, NB4)
hsa-miR-424-5p Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (ID8)
hsa-miR-424-5p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (TAMR4, TAMR8)
hsa-miR-424-5p Paclitaxel 36314 NSC125973 approved sensitive Low Breast Cancer tissue and cell line
hsa-miR-424-5p Curcumin 969516 NSC32982 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-424-5p Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-424-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-424-5p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-424-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-424-5p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (WM266) (1uM)
hsa-miR-424-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (WM266) (1uM)
hsa-miR-424-5p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-424-5p Cisplatin 5460033 NSC119875 approved resistant Low Bladder Cancer cell line (5637, J82, BIU87, T24)
hsa-miR-424-5p Cisplatin 5460033 NSC119875 approved sensitive High Bladder Cancer cell line (CDDP-R-BOY, CDDP-R-T24)
hsa-miR-424-5p Taxol 36314 NSC125973 approved sensitive Low Breast Cancer cell line (MDA-MB-231)
hsa-miR-424-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375)
hsa-miR-424-5p Fluorouracil 3385 NSC19893 approved sensitive Low Colon Cancer cell line (HT-29)
hsa-miR-424-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7, PLC)
hsa-miR-424-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-424-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-424-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-424-5p Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-424-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKVO3ip1)
hsa-miR-424-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-424-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-424-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-424-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM43)
hsa-miR-424-5p Exemestane 60198 NSC713563 approved resistant cell line (MCF-7)
hsa-miR-424-5p Testosterone+Anastrozole resistant cell line (MCF-7)
hsa-miR-424-5p Testosterone+Exemestane resistant cell line (MCF-7)
hsa-miR-424-5p Testosterone+Tamoxifen resistant cell line (MCF-7)
hsa-miR-424-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-424-5p 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-miR-424-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-424-5p Sunitinib 5329102 NSC750690 approved sensitive tissue (CardA)
hsa-miR-424-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-424-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-424-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR4)
hsa-miR-424-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR20)
hsa-miR-424-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR70)
hsa-miR-424-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-miR-424-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-424-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-424-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-424-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-424-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR1)
hsa-miR-424-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-424-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-424-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-424-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (OVCAR3)
hsa-miR-424-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-424-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)
hsa-miR-424-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-424-5p Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)
hsa-miR-424-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (TOV-112D)

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