miRTarBase - #MIRT005969


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pre-miRNA Information
pre-miRNA hsa-mir-216a   
Genomic Coordinates chr2: 55988950 - 55989059
Description Homo sapiens miR-216a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216a-5p
Sequence 19| UAAUCUCAGCUGGCAACUGUGA |40
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 15 2 - 55989027 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs757094946 2 dbSNP
rs746980700 8 dbSNP
rs1249388997 12 dbSNP
rs1188616124 15 dbSNP
rs1490501989 19 dbSNP
rs1465789697 20 dbSNP
rs370221981 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Tissue .
BA0G4V miR-216a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol CD44   
Synonyms CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1
Description CD44 molecule (Indian blood group)
Transcript NM_001001392   
Other Transcripts NM_001001389 , NM_001001390 , NM_001001391 , NM_000610   
Expression
Putative miRNA Targets on CD44
3'UTR of CD44
(miRNA target sites are highlighted)		 
>CD44|NM_001001392|3'UTR
   1 TGAGACAAGGAACCTGCAGAATGTGGACATGAAGATTGGGGTGTAACACCTACACCATTATCTTGGAAAGAAACAACCGT
  81 TGGAAACATAACCATTACAGGGAGCTGGGACACTTAACAGATGCAATGTGCTACTGATTGTTTCATTGCGAATCTTTTTT
 161 AGCATAAAATTTTCTACTCTTTTTGTTTTTTGTGTTTTGTTCTTTAAAGTCAGGTCCAATTTGTAAAAACAGCATTGCTT
 241 TCTGAAATTAGGGCCCAATTAATAATCAGCAAGAATTTGATCGTTCCAGTTCCCACTTGGAGGCCTTTCATCCCTCGGGT
 321 GTGCTATGGATGGCTTCTAACAAAAACTACACATATGTATTCCTGATCGCCAACCTTTCCCCCACCAGCTAAGGACATTT
 401 CCCAGGGTTAATAGGGCCTGGTCCCTGGGAGGAAATTTGAATGGGTCCATTTTGCCCTTCCATAGCCTAATCCCTGGGCA
 481 TTGCTTTCCACTGAGGTTGGGGGTTGGGGTGTACTAGTTACACATCTTCAACAGACCCCCTCTAGAAATTTTTCAGATGC
 561 TTCTGGGAGACACCCAAAGGGTGAAGCTATTTATCTGTAGTAAACTATTTATCTGTGTTTTTGAAATATTAAACCCTGGA
 641 TCAGTCCTTTGATCAGTATAATTTTTTAAAGTTACTTTGTCAGAGGCACAAAAGGGTTTAAACTGATTCATAATAAATAT
 721 CTGTACTTCTTCGATCTTCACCTTTTGTGCTGTGATTCTTCAGTTTCTAAACCAGCACTGTCTGGGTCCCTACAATGTAT
 801 CAGGAAGAGCTGAGAATGGTAAGGAGACTCTTCTAAGTCTTCATCTCAGAGACCCTGAGTTCCCACTCAGACCCACTCAG
 881 CCAAATCTCATGGAAGACCAAGGAGGGCAGCACTGTTTTTGTTTTTTGTTTTTTGTTTTTTTTTTTTGACACTGTCCAAA
 961 GGTTTTCCATCCTGTCCTGGAATCAGAGTTGGAAGCTGAGGAGCTTCAGCCTCTTTTATGGTTTAATGGCCACCTGTTCT
1041 CTCCTGTGAAAGGCTTTGCAAAGTCACATTAAGTTTGCATGACCTGTTATCCCTGGGGCCCTATTTCATAGAGGCTGGCC
1121 CTATTAGTGATTTCCAAAAACAATATGGAAGTGCCTTTTGATGTCTTACAATAAGAGAAGAAGCCAATGGAAATGAAAGA
1201 GATTGGCAAAGGGGAAGGATGATGCCATGTAGATCCTGTTTGACATTTTTATGGCTGTATTTGTAAACTTAAACACACCA
1281 GTGTCTGTTCTTGATGCAGTTGCTATTTAGGATGAGTTAAGTGCCTGGGGAGTCCCTCAAAAGGTTAAAGGGATTCCCAT
1361 CATTGGAATCTTATCACCAGATAGGCAAGTTTATGACCAAACAAGAGAGTACTGGCTTTATCCTCTAACCTCATATTTTC
1441 TCCCACTTGGCAAGTCCTTTGTGGCATTTATTCATCAGTCAGGGTGTCCGATTGGTCCTAGAACTTCCAAAGGCTGCTTG
1521 TCATAGAAGCCATTGCATCTATAAAGCAACGGCTCCTGTTAAATGGTATCTCCTTTCTGAGGCTCCTACTAAAAGTCATT
1601 TGTTACCTAAACTTATGTGCTTAACAGGCAATGCTTCTCAGACCACAAAGCAGAAAGAAGAAGAAAAGCTCCTGACTAAA
1681 TCAGGGCTGGGCTTAGACAGAGTTGATCTGTAGAATATCTTTAAAGGAGAGATGTCAACTTTCTGCACTATTCCCAGCCT
1761 CTGCTCCTCCCTGTCTACCCTCTCCCCTCCCTCTCTCCCTCCACTTCACCCCACAATCTTGAAAAACTTCCTTTCTCTTC
1841 TGTGAACATCATTGGCCAGATCCATTTTCAGTGGTCTGGATTTCTTTTTATTTTCTTTTCAACTTGAAAGAAACTGGACA
1921 TTAGGCCACTATGTGTTGTTACTGCCACTAGTGTTCAAGTGCCTCTTGTTTTCCCAGAGATTTCCTGGGTCTGCCAGAGG
2001 CCCAGACAGGCTCACTCAAGCTCTTTAACTGAAAAGCAACAAGCCACTCCAGGACAAGGTTCAAAATGGTTACAACAGCC
2081 TCTACCTGTCGCCCCAGGGAGAAAGGGGTAGTGATACAAGTCTCATAGCCAGAGATGGTTTTCCACTCCTTCTAGATATT
2161 CCCAAAAAGAGGCTGAGACAGGAGGTTATTTTCAATTTTATTTTGGAATTAAATACTTTTTTCCCTTTATTACTGTTGTA
2241 GTCCCTCACTTGGATATACCTCTGTTTTCACGATAGAAATAAGGGAGGTCTAGAGCTTCTATTCCTTGGCCATTGTCAAC
2321 GGAGAGCTGGCCAAGTCTTCACAAACCCTTGCAACATTGCCTGAAGTTTATGGAATAAGATGTATTCTCACTCCCTTGAT
2401 CTCAAGGGCGTAACTCTGGAAGCACAGCTTGACTACACGTCATTTTTACCAATGATTTTCAGGTGACCTGGGCTAAGTCA
2481 TTTAAACTGGGTCTTTATAAAAGTAAAAGGCCAACATTTAATTATTTTGCAAAGCAACCTAAGAGCTAAAGATGTAATTT
2561 TTCTTGCAATTGTAAATCTTTTGTGTCTCCTGAAGACTTCCCTTAAAATTAGCTCTGAGTGAAAAATCAAAAGAGACAAA
2641 AGACATCTTCGAATCCATATTTCAAGCCTGGTAGAATTGGCTTTTCTAGCAGAACCTTTCCAAAAGTTTTATATTGAGAT
2721 TCATAACAACACCAAGAATTGATTTTGTAGCCAACATTCATTCAATACTGTTATATCAGAGGAGTAGGAGAGAGGAAACA
2801 TTTGACTTATCTGGAAAAGCAAAATGTACTTAAGAATAAGAATAACATGGTCCATTCACCTTTATGTTATAGATATGTCT
2881 TTGTGTAAATCATTTGTTTTGAGTTTTCAAAGAATAGCCCATTGTTCATTCTTGTGCTGTACAATGACCACTGTTATTGT
2961 TACTTTGACTTTTCAGAGCACACCCTTCCTCTGGTTTTTGTATATTTATTGATGGATCAATAATAATGAGGAAAGCATGA
3041 TATGTATATTGCTGAGTTGAAAGCACTTATTGGAAAATATTAAAAGGCTAACATTAAAAGACTAAAGGAAACAGAAAAAA
3121 AAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agUGUCAACGGUCGACUCUAAu 5'
            | |||| :   :||||||| 
Target 5' caAAAGTTTTATATTGAGATTc 3'
 2701 - 2722 152.00 -8.20
2 
miRNA  3' agugucAACGGUCGACUCUAAu 5'
                || ||| |||||:|| 
Target 5' cattgcTTTCCA-CTGAGGTTg 3'
 479 - 499 143.00 -14.20
3 
miRNA  3' agUGUC--AACGGUCGACUCUAAu 5'
            ||||  ||||:  |||| ||| 
Target 5' aaACAGCATTGCTTTCTGAAATTa 3'
 227 - 250 138.00 -13.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
750297 5 ClinVar
COSM6623788 10 COSMIC
COSM5638835 20 COSMIC
COSM926672 22 COSMIC
COSN31574697 71 COSMIC
COSN20077251 98 COSMIC
COSN5908134 150 COSMIC
COSN20578006 360 COSMIC
COSN17181752 532 COSMIC
COSN10085447 645 COSMIC
COSN2508335 894 COSMIC
COSN7003748 935 COSMIC
COSN17703312 943 COSMIC
COSN20108144 948 COSMIC
COSN29980542 1406 COSMIC
COSN22598619 1702 COSMIC
COSN21431653 1706 COSMIC
COSN31584292 1896 COSMIC
COSN8641561 1951 COSMIC
COSN21537883 1979 COSMIC
COSN25422794 2088 COSMIC
COSN14966914 2196 COSMIC
COSN8443277 2687 COSMIC
COSN1529947 2912 COSMIC
COSN31531628 2918 COSMIC
COSN31487241 2932 COSMIC
COSN31479884 3055 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1204803334 1 dbSNP
rs1316405523 4 dbSNP
rs760882696 5 dbSNP
rs188636640 6 dbSNP
rs377420041 10 dbSNP
rs1468695667 11 dbSNP
rs757573491 13 dbSNP
rs765550004 14 dbSNP
rs1476335616 17 dbSNP
rs371083245 19 dbSNP
rs1186991338 24 dbSNP
rs750891021 27 dbSNP
rs758874926 30 dbSNP
rs200314711 33 dbSNP
rs751176867 35 dbSNP
rs1461177395 37 dbSNP
rs754553244 39 dbSNP
rs1347080117 40 dbSNP
rs376116333 41 dbSNP
rs747837576 42 dbSNP
rs1173456893 46 dbSNP
rs1339095360 47 dbSNP
rs139168368 48 dbSNP
rs777480697 50 dbSNP
rs370529337 51 dbSNP
rs193274645 53 dbSNP
rs1208910054 56 dbSNP
rs1035147328 57 dbSNP
rs1287334291 57 dbSNP
rs1317137875 58 dbSNP
rs1448169042 60 dbSNP
rs1215905532 61 dbSNP
rs537145227 62 dbSNP
rs760688690 63 dbSNP
rs768725955 67 dbSNP
rs1380182801 71 dbSNP
rs776791739 71 dbSNP
rs1028053045 75 dbSNP
rs1290993646 77 dbSNP
rs143090019 79 dbSNP
rs750789485 80 dbSNP
rs1410468166 82 dbSNP
rs763508579 83 dbSNP
rs766939077 87 dbSNP
rs1192665841 88 dbSNP
rs35608218 92 dbSNP
rs752120923 93 dbSNP
rs761439402 94 dbSNP
rs780874018 95 dbSNP
rs1019681296 97 dbSNP
rs570810043 99 dbSNP
rs776374299 99 dbSNP
rs1239988533 105 dbSNP
rs1023815924 111 dbSNP
rs538584964 119 dbSNP
rs952317058 125 dbSNP
rs1205507039 131 dbSNP
rs961111353 140 dbSNP
rs1269082125 145 dbSNP
rs767129598 147 dbSNP
rs558786273 150 dbSNP
rs572162381 151 dbSNP
rs750196328 165 dbSNP
rs1463491375 173 dbSNP
rs1161958643 180 dbSNP
rs1390163934 181 dbSNP
rs2295755 185 dbSNP
rs554708642 195 dbSNP
rs1403629376 201 dbSNP
rs574628378 203 dbSNP
rs927372216 212 dbSNP
rs1460576307 214 dbSNP
rs755887039 217 dbSNP
rs1443730363 221 dbSNP
rs1241056379 222 dbSNP
rs938752301 225 dbSNP
rs992949644 234 dbSNP
rs1272275857 238 dbSNP
rs913221221 243 dbSNP
rs946078215 246 dbSNP
rs879007234 248 dbSNP
rs1274859328 249 dbSNP
rs1244815625 250 dbSNP
rs1382416433 252 dbSNP
rs1313372761 253 dbSNP
rs1338731834 254 dbSNP
rs543532111 271 dbSNP
rs1293712965 274 dbSNP
rs976234509 277 dbSNP
rs1357077369 283 dbSNP
rs923048446 284 dbSNP
rs766331136 285 dbSNP
rs1169402518 287 dbSNP
rs1242566504 293 dbSNP
rs1424269576 302 dbSNP
rs1383687101 305 dbSNP
rs1264789688 314 dbSNP
rs931774687 318 dbSNP
rs1050267891 321 dbSNP
rs753809076 329 dbSNP
rs563304886 340 dbSNP
rs532109447 343 dbSNP
rs1041668880 347 dbSNP
rs541907705 351 dbSNP
rs1356811095 354 dbSNP
rs999533756 357 dbSNP
rs1230359977 360 dbSNP
rs1357537660 365 dbSNP
rs527513660 369 dbSNP
rs896590635 376 dbSNP
rs1186137568 383 dbSNP
rs1368389972 385 dbSNP
rs1012347414 387 dbSNP
rs1404471855 388 dbSNP
rs1470767113 389 dbSNP
rs1325821729 390 dbSNP
rs1405695326 391 dbSNP
rs1407002308 391 dbSNP
rs115514407 396 dbSNP
rs1473532988 404 dbSNP
rs1358658380 412 dbSNP
rs1019392065 418 dbSNP
rs754883447 419 dbSNP
rs1270547522 421 dbSNP
rs985440093 422 dbSNP
rs1284015154 424 dbSNP
rs1313678989 425 dbSNP
rs993794402 434 dbSNP
rs1289577657 466 dbSNP
rs777891660 467 dbSNP
rs747111620 468 dbSNP
rs1394053490 474 dbSNP
rs1311672599 477 dbSNP
rs975785832 484 dbSNP
rs8193 485 dbSNP
rs931701023 490 dbSNP
rs1315953387 491 dbSNP
rs1458665868 499 dbSNP
rs1389253481 500 dbSNP
rs1001770292 501 dbSNP
rs985905718 504 dbSNP
rs1426683337 505 dbSNP
rs1191347229 509 dbSNP
rs960273848 510 dbSNP
rs548421422 513 dbSNP
rs1207191212 516 dbSNP
rs1466561477 520 dbSNP
rs3198807 524 dbSNP
rs781420194 537 dbSNP
rs1203605751 541 dbSNP
rs78006686 543 dbSNP
rs967348504 546 dbSNP
rs1219953187 553 dbSNP
rs1361505818 557 dbSNP
rs1199110788 558 dbSNP
rs924557569 559 dbSNP
rs183338024 572 dbSNP
rs925973736 589 dbSNP
rs1468172030 590 dbSNP
rs376644571 591 dbSNP
rs1378601670 592 dbSNP
rs761324950 599 dbSNP
rs1056488860 607 dbSNP
rs1049706110 609 dbSNP
rs896515927 616 dbSNP
rs1416907910 618 dbSNP
rs1190144866 624 dbSNP
rs1439159540 627 dbSNP
rs560488633 636 dbSNP
rs1397131223 641 dbSNP
rs187656451 656 dbSNP
rs1482559053 679 dbSNP
rs1258345166 681 dbSNP
rs539783740 682 dbSNP
rs1445185429 683 dbSNP
rs1307027697 685 dbSNP
rs943891977 687 dbSNP
rs1342527797 698 dbSNP
rs1314105367 711 dbSNP
rs1302075846 714 dbSNP
rs1396879281 725 dbSNP
rs147094573 728 dbSNP
rs749868070 730 dbSNP
rs769281385 731 dbSNP
rs191774350 733 dbSNP
rs1440782769 734 dbSNP
rs1352284063 749 dbSNP
rs538245866 750 dbSNP
rs1048035986 751 dbSNP
rs962338215 753 dbSNP
rs998200269 763 dbSNP
rs1310083284 787 dbSNP
rs1001737678 794 dbSNP
rs1232028802 811 dbSNP
rs1182980382 813 dbSNP
rs1255796417 815 dbSNP
rs1340471430 820 dbSNP
rs528432831 824 dbSNP
rs1249719605 825 dbSNP
rs1034641462 827 dbSNP
rs1236869739 829 dbSNP
rs953057370 842 dbSNP
rs985873062 843 dbSNP
rs556553099 850 dbSNP
rs77528339 855 dbSNP
rs1323315722 863 dbSNP
rs1313280726 874 dbSNP
rs968920870 879 dbSNP
rs761326818 882 dbSNP
rs574668948 890 dbSNP
rs1431680868 913 dbSNP
rs978866466 914 dbSNP
rs924501866 915 dbSNP
rs1166029652 916 dbSNP
rs1300941368 916 dbSNP
rs1370581601 916 dbSNP
rs1456670869 916 dbSNP
rs925944050 917 dbSNP
rs1410474770 919 dbSNP
rs1184412007 923 dbSNP
rs367878126 927 dbSNP
rs1208309663 928 dbSNP
rs1268396909 928 dbSNP
rs112847750 929 dbSNP
rs1214886636 929 dbSNP
rs1326976493 929 dbSNP
rs1489306657 929 dbSNP
rs1228432604 930 dbSNP
rs1290189071 930 dbSNP
rs917909742 934 dbSNP
rs985744622 935 dbSNP
rs1162037240 936 dbSNP
rs1387054056 936 dbSNP
rs397849775 936 dbSNP
rs556208241 936 dbSNP
rs78387531 936 dbSNP
rs1472930449 937 dbSNP
rs34137404 937 dbSNP
rs1045089962 938 dbSNP
rs1435120145 938 dbSNP
rs1204305537 941 dbSNP
rs887871809 941 dbSNP
rs200904906 942 dbSNP
rs867390021 942 dbSNP
rs200013606 943 dbSNP
rs201376677 949 dbSNP
rs898017447 954 dbSNP
rs918448236 955 dbSNP
rs1441469166 957 dbSNP
rs1234857501 972 dbSNP
rs537169543 973 dbSNP
rs929708800 980 dbSNP
rs1048171256 990 dbSNP
rs183987562 995 dbSNP
rs1030625676 998 dbSNP
rs1385922654 1000 dbSNP
rs554295209 1001 dbSNP
rs1308505083 1010 dbSNP
rs76121131 1012 dbSNP
rs1406076911 1014 dbSNP
rs1256485404 1027 dbSNP
rs1467688754 1028 dbSNP
rs1378389776 1031 dbSNP
rs1192781140 1034 dbSNP
rs1317870581 1040 dbSNP
rs1249669725 1042 dbSNP
rs1189054818 1043 dbSNP
rs896083871 1046 dbSNP
rs1254055423 1047 dbSNP
rs1201643998 1053 dbSNP
rs1345151370 1054 dbSNP
rs1250363586 1055 dbSNP
rs1225740347 1069 dbSNP
rs1214807798 1074 dbSNP
rs1014949644 1076 dbSNP
rs760285943 1077 dbSNP
rs1487527483 1078 dbSNP
rs766206410 1079 dbSNP
rs369084935 1084 dbSNP
rs1262683028 1086 dbSNP
rs1007238997 1093 dbSNP
rs1021354039 1096 dbSNP
rs968517670 1098 dbSNP
rs1397816479 1104 dbSNP
rs753621737 1107 dbSNP
rs1168127238 1110 dbSNP
rs774644131 1113 dbSNP
rs924458219 1114 dbSNP
rs1392325094 1120 dbSNP
rs960181109 1122 dbSNP
rs79780721 1128 dbSNP
rs1443822511 1131 dbSNP
rs953317372 1136 dbSNP
rs1189566209 1146 dbSNP
rs754978693 1152 dbSNP
rs948023748 1159 dbSNP
rs1202491834 1170 dbSNP
rs188719172 1173 dbSNP
rs559083566 1176 dbSNP
rs1483824767 1182 dbSNP
rs1018577897 1184 dbSNP
rs965309834 1188 dbSNP
rs373682305 1194 dbSNP
rs1288880491 1218 dbSNP
rs16927157 1219 dbSNP
rs1397704326 1229 dbSNP
rs942111691 1231 dbSNP
rs192197484 1232 dbSNP
rs1408135926 1238 dbSNP
rs983800823 1241 dbSNP
rs1384667447 1255 dbSNP
rs138211083 1258 dbSNP
rs1234481598 1270 dbSNP
rs897988663 1280 dbSNP
rs1411370308 1283 dbSNP
rs1315428436 1284 dbSNP
rs1473080836 1285 dbSNP
rs933476538 1289 dbSNP
rs1320061357 1295 dbSNP
rs1179358712 1296 dbSNP
rs1220948743 1299 dbSNP
rs1473309331 1307 dbSNP
rs1252036386 1318 dbSNP
rs1221307048 1322 dbSNP
rs936974485 1324 dbSNP
rs561975670 1330 dbSNP
rs1051981582 1341 dbSNP
rs1357643498 1344 dbSNP
rs768186414 1345 dbSNP
rs1055452147 1352 dbSNP
rs1262266914 1357 dbSNP
rs1352435480 1358 dbSNP
rs895495811 1360 dbSNP
rs950329194 1362 dbSNP
rs1042027054 1363 dbSNP
rs889382794 1364 dbSNP
rs1183597743 1374 dbSNP
rs564446399 1382 dbSNP
rs1412075074 1383 dbSNP
rs1000370356 1402 dbSNP
rs1476830206 1403 dbSNP
rs1007211089 1407 dbSNP
rs1248145634 1408 dbSNP
rs530982748 1410 dbSNP
rs1201426710 1411 dbSNP
rs1423104218 1413 dbSNP
rs1452584511 1415 dbSNP
rs751607778 1416 dbSNP
rs1268003952 1417 dbSNP
rs1159234329 1420 dbSNP
rs1033068839 1433 dbSNP
rs75661437 1435 dbSNP
rs889216361 1447 dbSNP
rs1008084085 1448 dbSNP
rs1021283413 1451 dbSNP
rs1365724804 1466 dbSNP
rs1276871963 1473 dbSNP
rs1436881690 1484 dbSNP
rs1018927210 1485 dbSNP
rs1318389848 1487 dbSNP
rs1417530617 1490 dbSNP
rs904218556 1493 dbSNP
rs550675283 1494 dbSNP
rs998609884 1495 dbSNP
rs1031878684 1497 dbSNP
rs966479307 1509 dbSNP
rs959862111 1514 dbSNP
rs564562340 1522 dbSNP
rs757313305 1525 dbSNP
rs969929859 1526 dbSNP
rs1172826569 1536 dbSNP
rs1025523461 1539 dbSNP
rs1360364415 1540 dbSNP
rs1449191713 1543 dbSNP
rs781302676 1551 dbSNP
rs533174554 1552 dbSNP
rs1243245541 1559 dbSNP
rs1209464639 1564 dbSNP
rs1310547666 1565 dbSNP
rs547015870 1568 dbSNP
rs1307829802 1571 dbSNP
rs1341805126 1572 dbSNP
rs972133188 1573 dbSNP
rs919340887 1574 dbSNP
rs753220702 1582 dbSNP
rs184575777 1584 dbSNP
rs1302227705 1585 dbSNP
rs1445114231 1587 dbSNP
rs991689470 1588 dbSNP
rs1051949825 1597 dbSNP
rs1238297753 1598 dbSNP
rs1334330935 1599 dbSNP
rs74685658 1606 dbSNP
rs1485910556 1613 dbSNP
rs548480951 1618 dbSNP
rs546895151 1621 dbSNP
rs1420796551 1626 dbSNP
rs1482898049 1628 dbSNP
rs138442516 1629 dbSNP
rs764217659 1630 dbSNP
rs1211764536 1632 dbSNP
rs1437268963 1635 dbSNP
rs190309609 1645 dbSNP
rs1395326279 1649 dbSNP
rs1272803515 1651 dbSNP
rs142806428 1655 dbSNP
rs1415758996 1678 dbSNP
rs576918951 1684 dbSNP
rs1336596502 1687 dbSNP
rs1031385263 1688 dbSNP
rs1381335731 1703 dbSNP
rs1357739152 1704 dbSNP
rs149643293 1706 dbSNP
rs11821102 1711 dbSNP
rs1332595335 1717 dbSNP
rs1309503207 1719 dbSNP
rs1014020570 1728 dbSNP
rs1431962191 1732 dbSNP
rs1355492136 1734 dbSNP
rs1007640875 1745 dbSNP
rs1379299210 1750 dbSNP
rs1444640424 1760 dbSNP
rs1308538766 1764 dbSNP
rs572486381 1766 dbSNP
rs1249836252 1767 dbSNP
rs969897479 1774 dbSNP
rs542140809 1778 dbSNP
rs144413642 1779 dbSNP
rs1264637236 1781 dbSNP
rs1205210493 1783 dbSNP
rs993908424 1787 dbSNP
rs116943323 1790 dbSNP
rs1227198601 1793 dbSNP
rs963374222 1794 dbSNP
rs951287504 1802 dbSNP
rs772269339 1803 dbSNP
rs1177475645 1805 dbSNP
rs1410057777 1811 dbSNP
rs1253040977 1812 dbSNP
rs544742356 1817 dbSNP
rs1293282640 1825 dbSNP
rs1456751358 1829 dbSNP
rs1352084583 1835 dbSNP
rs954759600 1839 dbSNP
rs868599762 1848 dbSNP
rs987584818 1849 dbSNP
rs991221435 1853 dbSNP
rs1423558539 1862 dbSNP
rs769298009 1863 dbSNP
rs79220468 1872 dbSNP
rs943558652 1874 dbSNP
rs1189212481 1880 dbSNP
rs182547752 1885 dbSNP
rs971066505 1891 dbSNP
rs148796664 1900 dbSNP
rs1043275867 1902 dbSNP
rs1273677902 1910 dbSNP
rs1208044687 1919 dbSNP
rs926205582 1920 dbSNP
rs1326372643 1937 dbSNP
rs1269472974 1940 dbSNP
rs1239199564 1946 dbSNP
rs1330119451 1951 dbSNP
rs1403105670 1962 dbSNP
rs934316734 1964 dbSNP
rs1370205032 1966 dbSNP
rs1445158881 1967 dbSNP
rs1053217476 1971 dbSNP
rs1435008465 1980 dbSNP
rs1387171002 1982 dbSNP
rs1330789856 1984 dbSNP
rs1454407048 1985 dbSNP
rs1331731554 1994 dbSNP
rs977096775 1999 dbSNP
rs1174245688 2002 dbSNP
rs1438920896 2006 dbSNP
rs924300757 2011 dbSNP
rs895514107 2018 dbSNP
rs1026928797 2032 dbSNP
rs200858070 2038 dbSNP
rs886858428 2041 dbSNP
rs1259678264 2048 dbSNP
rs774870810 2049 dbSNP
rs936217547 2051 dbSNP
rs1463478372 2056 dbSNP
rs560498218 2060 dbSNP
rs111439345 2064 dbSNP
rs879543811 2070 dbSNP
rs200482671 2076 dbSNP
rs943540337 2077 dbSNP
rs1040419973 2080 dbSNP
rs529275514 2087 dbSNP
rs905664444 2091 dbSNP
rs1005803205 2092 dbSNP
rs61882771 2093 dbSNP
rs1194885272 2097 dbSNP
rs961608101 2098 dbSNP
rs994120350 2105 dbSNP
rs1454513468 2112 dbSNP
rs185818511 2118 dbSNP
rs954728808 2130 dbSNP
rs1017273160 2135 dbSNP
rs1391621765 2136 dbSNP
rs987553466 2138 dbSNP
rs758170794 2145 dbSNP
rs537340563 2149 dbSNP
rs550792662 2150 dbSNP
rs971539688 2158 dbSNP
rs1228071676 2160 dbSNP
rs189111291 2164 dbSNP
rs934890645 2165 dbSNP
rs1228797691 2168 dbSNP
rs780006530 2183 dbSNP
rs1053405904 2186 dbSNP
rs1416752448 2210 dbSNP
rs1376251467 2218 dbSNP
rs916910251 2223 dbSNP
rs1427519156 2227 dbSNP
rs1284705597 2235 dbSNP
rs1398372304 2238 dbSNP
rs369742293 2239 dbSNP
rs112374351 2240 dbSNP
rs1188987420 2250 dbSNP
rs1357922849 2258 dbSNP
rs990365979 2260 dbSNP
rs771650286 2263 dbSNP
rs1207565943 2269 dbSNP
rs1482237969 2272 dbSNP
rs76297791 2273 dbSNP
rs1488424735 2282 dbSNP
rs1218311540 2283 dbSNP
rs1005360287 2294 dbSNP
rs10836347 2300 dbSNP
rs897016507 2301 dbSNP
rs923487430 2303 dbSNP
rs1235161205 2306 dbSNP
rs1477041217 2311 dbSNP
rs760373802 2312 dbSNP
rs1029626883 2320 dbSNP
rs1016518464 2321 dbSNP
rs954657144 2322 dbSNP
rs1047837520 2327 dbSNP
rs766019839 2332 dbSNP
rs1388434550 2337 dbSNP
rs1017673460 2345 dbSNP
rs964809499 2347 dbSNP
rs1410585639 2355 dbSNP
rs1179474013 2364 dbSNP
rs978893766 2371 dbSNP
rs1233148558 2376 dbSNP
rs1372723959 2382 dbSNP
rs115718630 2383 dbSNP
rs942040680 2384 dbSNP
rs1038269810 2388 dbSNP
rs1267574238 2392 dbSNP
rs956270758 2399 dbSNP
rs1358464596 2402 dbSNP
rs1280394193 2407 dbSNP
rs150714844 2410 dbSNP
rs917507263 2411 dbSNP
rs1327756526 2417 dbSNP
rs1286586375 2429 dbSNP
rs949691045 2436 dbSNP
rs13347 2439 dbSNP
rs926983186 2440 dbSNP
rs113729978 2445 dbSNP
rs747687146 2448 dbSNP
rs752643025 2454 dbSNP
rs769389438 2456 dbSNP
rs544566071 2472 dbSNP
rs1171654321 2474 dbSNP
rs1283141696 2475 dbSNP
rs1038157970 2477 dbSNP
rs1353762107 2478 dbSNP
rs1463002683 2478 dbSNP
rs1477867921 2480 dbSNP
rs896979239 2487 dbSNP
rs181556133 2488 dbSNP
rs1283418763 2498 dbSNP
rs371161252 2505 dbSNP
rs1206863124 2510 dbSNP
rs998597074 2512 dbSNP
rs1285143350 2515 dbSNP
rs1487722849 2516 dbSNP
rs1343217340 2517 dbSNP
rs1050969681 2519 dbSNP
rs891061660 2524 dbSNP
rs1257250618 2531 dbSNP
rs1031432310 2540 dbSNP
rs1318494755 2541 dbSNP
rs762769835 2544 dbSNP
rs956987248 2545 dbSNP
rs990240987 2546 dbSNP
rs1368013662 2552 dbSNP
rs1175887640 2553 dbSNP
rs185300326 2558 dbSNP
rs750526204 2565 dbSNP
rs139216749 2569 dbSNP
rs1184777934 2570 dbSNP
rs1185296592 2579 dbSNP
rs1476392677 2583 dbSNP
rs1242770829 2584 dbSNP
rs1017599781 2587 dbSNP
rs900530856 2594 dbSNP
rs1209575720 2601 dbSNP
rs115214213 2610 dbSNP
rs965313607 2614 dbSNP
rs976402323 2616 dbSNP
rs1341226060 2618 dbSNP
rs543092581 2621 dbSNP
rs1216251869 2622 dbSNP
rs1362646841 2629 dbSNP
rs1283067339 2636 dbSNP
rs144026669 2638 dbSNP
rs1404055596 2644 dbSNP
rs756408001 2646 dbSNP
rs780364791 2647 dbSNP
rs530868771 2652 dbSNP
rs1333424201 2656 dbSNP
rs983462361 2667 dbSNP
rs1370337970 2669 dbSNP
rs754275348 2672 dbSNP
rs1430794723 2676 dbSNP
rs909321538 2677 dbSNP
rs942009665 2678 dbSNP
rs755351639 2680 dbSNP
rs1474284800 2685 dbSNP
rs1259815072 2688 dbSNP
rs1188930434 2689 dbSNP
rs1055520892 2691 dbSNP
rs1249391695 2696 dbSNP
rs1307976254 2697 dbSNP
rs1289103170 2706 dbSNP
rs1226073238 2715 dbSNP
rs1356835542 2716 dbSNP
rs1293451723 2720 dbSNP
rs1024485488 2724 dbSNP
rs971601195 2726 dbSNP
rs1348300412 2737 dbSNP
rs1296785939 2747 dbSNP
rs980348272 2748 dbSNP
rs865984366 2749 dbSNP
rs1459887162 2756 dbSNP
rs1352565747 2760 dbSNP
rs1420109009 2764 dbSNP
rs1165822621 2771 dbSNP
rs1045681491 2773 dbSNP
rs906999712 2774 dbSNP
rs764285822 2785 dbSNP
rs941076933 2791 dbSNP
rs1233462749 2801 dbSNP
rs974192884 2807 dbSNP
rs998690487 2810 dbSNP
rs1031401201 2812 dbSNP
rs1211741870 2813 dbSNP
rs1257008505 2815 dbSNP
rs146486632 2829 dbSNP
rs1273253070 2844 dbSNP
rs929770423 2846 dbSNP
rs191477813 2848 dbSNP
rs1017686746 2849 dbSNP
rs1393450522 2850 dbSNP
rs1374525292 2851 dbSNP
rs1293378013 2853 dbSNP
rs1458561002 2856 dbSNP
rs1180593240 2857 dbSNP
rs890989625 2863 dbSNP
rs1397386062 2867 dbSNP
rs532951143 2869 dbSNP
rs1236392011 2877 dbSNP
rs1456809410 2885 dbSNP
rs964444353 2888 dbSNP
rs1418769504 2895 dbSNP
rs1161575158 2901 dbSNP
rs1419386938 2903 dbSNP
rs976707579 2905 dbSNP
rs942582246 2910 dbSNP
rs1039681640 2918 dbSNP
rs950863487 2921 dbSNP
rs900461591 2928 dbSNP
rs546686135 2929 dbSNP
rs1262062725 2935 dbSNP
rs1033482851 2936 dbSNP
rs1239322924 2942 dbSNP
rs759854197 2945 dbSNP
rs748734277 2947 dbSNP
rs891894624 2955 dbSNP
rs1303103226 2957 dbSNP
rs1400942778 2960 dbSNP
rs566181907 2961 dbSNP
rs1010298018 2972 dbSNP
rs990957768 2985 dbSNP
rs1327196094 2987 dbSNP
rs1024413375 2994 dbSNP
rs1434396003 2997 dbSNP
rs1382893317 3003 dbSNP
rs139896508 3005 dbSNP
rs554982246 3010 dbSNP
rs949420647 3016 dbSNP
rs568494178 3017 dbSNP
rs1034612007 3021 dbSNP
rs1455444033 3022 dbSNP
rs538558179 3025 dbSNP
rs1187866024 3028 dbSNP
rs1426153805 3040 dbSNP
rs1046019997 3044 dbSNP
rs928555078 3049 dbSNP
rs1482707269 3052 dbSNP
rs772440450 3054 dbSNP
rs934452615 3061 dbSNP
rs1209119900 3071 dbSNP
rs1387036438 3079 dbSNP
rs962661146 3094 dbSNP
rs1227342619 3115 dbSNP
rs1325256760 3116 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions MT-1
Location of target site 3'UTR
Original Description (Extracted from the article) ... "Computational algorithms have predicted three miRNAs ...

- Jeyapalan Z; Deng Z; Shatseva T; Fang L; He et al., 2011, Nucleic acids research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agugucAACGGUCGACUCUAAu 5'
                || ||| |||||:|| 
Target 5' cattgcTTTCCA-CTGAGGTTg 3'
 		4 - 24
Article - Jeyapalan Z; Deng Z; Shatseva T; Fang L; He et al.
- Nucleic acids research, 2011
The non-coding 3'-untranslated region (UTR) plays an important role in the regulation of microRNA (miRNA) functions, since it can bind and inactivate multiple miRNAs. Here, we show the 3'-UTR of CD44 is able to antagonize cytoplasmic miRNAs, and result in the increased translation of CD44 and downstream target mRNA, CDC42. A series of cell function assays in the human breast cancer cell line, MT-1, have shown that the CD44 3'-UTR inhibits proliferation, colony formation and tumor growth. Furthermore, it modulated endothelial cell activities, favored angiogenesis, induced tumor cell apoptosis and increased sensitivity to Docetaxel. These results are due to the interaction of the CD44 3'-UTR with multiple miRNAs. Computational algorithms have predicted three miRNAs, miR-216a, miR-330 and miR-608, can bind to both the CD44 and CDC42 3'-UTRs. This was confirmed with luciferase assays, western blotting and immunohistochemical staining and correlated with a series of siRNA assays. Thus, the non-coding CD44 3'-UTR serves as a competitor for miRNA binding and subsequently inactivates miRNA functions, by freeing the target mRNAs from being repressed.
LinkOut: [PMID: 21149267]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.79 3.7e-6 0.699 1.0e-4 23 Click to see details
GSE28544 Breast cancer -0.69 9.5e-5 -0.683 1.2e-4 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.501 1.2e-2 0.435 2.8e-2 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.423 1.8e-2 0.291 7.9e-2 25 Click to see details
GSE38226 Liver fibrosis -0.397 3.7e-2 -0.057 4.0e-1 21 Click to see details
GSE27834 Pluripotent stem cells -0.355 8.9e-2 -0.347 9.4e-2 16 Click to see details
GSE21687 Ependynoma primary tumors 0.126 1.6e-1 0.063 3.1e-1 64 Click to see details
GSE32688 Pancreatic cancer 0.18 1.6e-1 0.214 1.2e-1 32 Click to see details
GSE14794 Lymphoblastoid cells -0.092 1.9e-1 -0.058 2.9e-1 90 Click to see details
GSE28260 Renal cortex and medulla 0.171 2.9e-1 0.191 2.7e-1 13 Click to see details
GSE17306 Multiple myeloma -0.047 3.7e-1 0.409 1.8e-3 49 Click to see details
GSE21849 B cell lymphoma 0.054 3.9e-1 -0.155 2.1e-1 29 Click to see details
GSE26953 Aortic valvular endothelial cells 0.054 4.0e-1 0.024 4.6e-1 24 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.034 4.4e-1 0.485 7.0e-3 25 Click to see details
GSE19350 CNS germ cell tumors -0.016 4.8e-1 0.309 1.6e-1 12 Click to see details
GSE17498 Multiple myeloma 0.001 5.0e-1 -0.046 3.9e-1 40 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BLCA -0.735 0.01 -0.745 0.01 10 Click to see details
LIHC -0.351 0.01 -0.406 0 45 Click to see details
PRAD -0.31 0.04 -0.363 0.02 31 Click to see details
HNSC 0.313 0.07 0.204 0.18 23 Click to see details
CHOL 0.545 0.08 0.619 0.05 8 Click to see details
LUAD -0.484 0.09 -0.267 0.24 9 Click to see details
BRCA -0.208 0.16 -0.082 0.35 25 Click to see details
KIRC -0.187 0.17 -0.087 0.33 29 Click to see details
STAD -0.192 0.21 -0.096 0.34 20 Click to see details
UCEC -0.232 0.26 -0.236 0.26 10 Click to see details
KICH 0.186 0.29 0.400 0.11 11 Click to see details
ESCA -0.357 0.32 0.000 0.5 4 Click to see details
PAAD -0.349 0.33 -0.600 0.2 4 Click to see details
LUSC 0.097 0.34 0.084 0.36 20 Click to see details
THCA -0.046 0.38 -0.062 0.34 47 Click to see details
KIRP 0.072 0.39 -0.038 0.44 18 Click to see details
KIRP 0.072 0.39 -0.038 0.44 18 Click to see details
KIRP 0.072 0.39 -0.038 0.44 18 Click to see details
148 hsa-miR-216a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000534 PTEN phosphatase and tensin homolog 4 3
MIRT005018 SIRT1 sirtuin 1 3 1
MIRT005964 CDC42 cell division cycle 42 2 1
MIRT005969 CD44 CD44 molecule (Indian blood group) 2 1
MIRT007154 SMAD7 SMAD family member 7 1 1
MIRT054887 BECN1 beclin 1 5 3
MIRT067588 METAP2 methionyl aminopeptidase 2 2 6
MIRT099144 MYLIP myosin regulatory light chain interacting protein 2 12
MIRT162313 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT230668 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT256274 PHAX phosphorylated adaptor for RNA export 2 2
MIRT386817 RAD51L3-RFFL RAD51L3-RFFL readthrough 2 2
MIRT386825 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 2 2
MIRT438816 HNF4A hepatocyte nuclear factor 4 alpha 1 1
MIRT464699 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465962 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466046 TMEM189 transmembrane protein 189 2 2
MIRT466482 TECPR2 tectonin beta-propeller repeat containing 2 2 7
MIRT472209 NGFRAP1 brain expressed X-linked 3 2 4
MIRT472562 NACC1 nucleus accumbens associated 1 2 4
MIRT478921 CPS1 carbamoyl-phosphate synthase 1 2 2
MIRT480121 CALR calreticulin 2 2
MIRT497754 OXGR1 oxoglutarate receptor 1 2 2
MIRT497967 TWISTNB TWIST neighbor 2 2
MIRT502882 CDK4 cyclin dependent kinase 4 2 8
MIRT510191 MON1B MON1 homolog B, secretory trafficking associated 2 4
MIRT512407 CD84 CD84 molecule 2 2
MIRT513739 PSD3 pleckstrin and Sec7 domain containing 3 2 4
MIRT526257 DROSHA drosha ribonuclease III 2 2
MIRT528968 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT529599 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT529776 ZNF486 zinc finger protein 486 2 2
MIRT530110 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530504 FADS6 fatty acid desaturase 6 2 2
MIRT531437 PAK1 p21 (RAC1) activated kinase 1 2 2
MIRT534445 SDR16C5 short chain dehydrogenase/reductase family 16C member 5 2 2
MIRT537286 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT538451 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT543085 ACTB actin beta 2 2
MIRT550982 ZNF254 zinc finger protein 254 2 2
MIRT556259 MAPRE2 microtubule associated protein RP/EB family member 2 2 2
MIRT556639 LAMC1 laminin subunit gamma 1 2 2
MIRT559127 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT561405 TUBB2A tubulin beta 2A class IIa 2 2
MIRT569677 SEC23B Sec23 homolog B, coat complex II component 2 4
MIRT574660 KLHL15 kelch like family member 15 2 2
MIRT575030 Tecpr2 tectonin beta-propeller repeat containing 2 2 5
MIRT617683 JRKL JRK like 2 2
MIRT618540 SEMA5A semaphorin 5A 2 2
MIRT620805 C1orf27 chromosome 1 open reading frame 27 2 2
MIRT621569 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT622133 SP4 Sp4 transcription factor 2 2
MIRT624913 CTCFL CCCTC-binding factor like 2 2
MIRT625010 PAK4 p21 (RAC1) activated kinase 4 2 2
MIRT626644 ZNF551 zinc finger protein 551 2 2
MIRT626646 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT626672 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT627945 NNT nicotinamide nucleotide transhydrogenase 2 2
MIRT627963 NLK nemo like kinase 2 2
MIRT628767 SRSF7 serine and arginine rich splicing factor 7 2 2
MIRT629261 KDM2B lysine demethylase 2B 2 2
MIRT629422 ADM2 adrenomedullin 2 2 2
MIRT630238 SORD sorbitol dehydrogenase 2 2
MIRT631272 CENPM centromere protein M 2 4
MIRT631793 CLK4 CDC like kinase 4 2 2
MIRT632058 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT632485 RPS15A ribosomal protein S15a 2 2
MIRT632611 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632708 MTA3 metastasis associated 1 family member 3 2 2
MIRT632815 INO80 INO80 complex subunit 2 2
MIRT635956 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT636152 UBXN2A UBX domain protein 2A 2 2
MIRT636899 C5orf45 MRN complex interacting protein 2 4
MIRT636930 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 2
MIRT637457 ZNF324B zinc finger protein 324B 2 2
MIRT637900 SLC19A3 solute carrier family 19 member 3 2 2
MIRT639826 ZNF638 zinc finger protein 638 2 2
MIRT640445 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT640681 ARSK arylsulfatase family member K 2 2
MIRT641611 CAPN7 calpain 7 2 2
MIRT641676 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT646786 IL23R interleukin 23 receptor 2 2
MIRT648352 A2ML1 alpha-2-macroglobulin like 1 2 2
MIRT649144 SPATA5 spermatogenesis associated 5 2 2
MIRT649254 TRIM65 tripartite motif containing 65 2 2
MIRT652491 TMEM178B transmembrane protein 178B 2 2
MIRT653308 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT653945 SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase 2 2
MIRT654212 RNF19B ring finger protein 19B 2 2
MIRT654839 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT655159 PHF21A PHD finger protein 21A 2 2
MIRT655316 PDCD11 programmed cell death 11 2 2
MIRT655375 PAX3 paired box 3 2 2
MIRT657301 HOXB5 homeobox B5 2 2
MIRT657593 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT658460 FAM117B family with sequence similarity 117 member B 2 2
MIRT658716 ELOVL4 ELOVL fatty acid elongase 4 2 2
MIRT661640 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT661712 MTO1 mitochondrial tRNA translation optimization 1 2 4
MIRT661833 ZNF793 zinc finger protein 793 2 2
MIRT663805 BET1L Bet1 golgi vesicular membrane trafficking protein like 2 2
MIRT663884 CXorf56 chromosome X open reading frame 56 2 2
MIRT664672 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 2
MIRT665814 TMEM168 transmembrane protein 168 2 2
MIRT668159 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT668430 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT672306 GP2 glycoprotein 2 2 2
MIRT673101 SYNPO2L synaptopodin 2 like 2 2
MIRT673437 APAF1 apoptotic peptidase activating factor 1 2 2
MIRT673584 KDELC2 KDEL motif containing 2 2 2
MIRT673718 SLU7 SLU7 homolog, splicing factor 2 2
MIRT673777 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT674316 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT674820 FAM229B family with sequence similarity 229 member B 2 2
MIRT675179 BPTF bromodomain PHD finger transcription factor 2 2
MIRT675586 WWC1 WW and C2 domain containing 1 2 2
MIRT675812 MED28 mediator complex subunit 28 2 2
MIRT677632 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT683914 PSMB9 proteasome subunit beta 9 2 2
MIRT687135 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT691973 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT693078 AS3MT arsenite methyltransferase 2 2
MIRT694084 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT696292 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT696541 C3 complement C3 2 2
MIRT701955 MITF melanogenesis associated transcription factor 2 2
MIRT703276 GNG12 G protein subunit gamma 12 2 2
MIRT706852 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT706993 XPO5 exportin 5 2 2
MIRT710716 KRTAP6-1 keratin associated protein 6-1 2 2
MIRT711305 ACOX1 acyl-CoA oxidase 1 2 2
MIRT711514 ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2 2
MIRT711648 LIPG lipase G, endothelial type 2 2
MIRT711772 CCDC59 coiled-coil domain containing 59 2 2
MIRT714280 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT715048 PRPF38A pre-mRNA processing factor 38A 2 2
MIRT716934 INCENP inner centromere protein 2 2
MIRT717220 OTUD3 OTU deubiquitinase 3 2 2
MIRT717865 BICD2 BICD cargo adaptor 2 2 2
MIRT718836 SNX20 sorting nexin 20 2 2
MIRT720243 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT721969 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT724000 LMTK2 lemur tyrosine kinase 2 2 2
MIRT725193 SDAD1 SDA1 domain containing 1 2 2
MIRT731669 CBL Cbl proto-oncogene 3 1
MIRT732776 AQP4 aquaporin 4 3 0
MIRT733158 ITGA5 integrin subunit alpha 5 1 0
MIRT735623 TLR4 toll like receptor 4 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216a Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216a Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3, 2008, OVCAR10, OVCAR3, HeLa, MCF7, MDA-MB-468)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved sensitive High Small Cell Lung Cancer cell line (NCI-H69)
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant Low Hepatocellular Carcinoma tissue and cell line (HepG2, Hep3B, Huh-7, PLC/PRF/5, HCCLM3, Bel-7404, HLE, SK-HEP-1, SNU-449)
hsa-miR-216a-5p Fluorouracil 3385 NSC19893 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer tissue
hsa-miR-216a-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7)
hsa-miR-216a-5p Doxorubicin 31703 NSC123127 approved resistant Low Small Cell Lung Cancer cell line (H69, H446)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant Low Ovarian Cancer cell line (SKOV3, OVCA433)
hsa-miR-216a-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Gastric Cancer cell line (MGC, SGC)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-216a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-216a-5p Exemestane 60198 NSC713563 approved sensitive cell line (MCF-7)
hsa-miR-216a-5p Testosterone+Tamoxifen sensitive cell line (MCF-7)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-216a-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-216a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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