miRTarBase - #MIRT006147


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pre-miRNA Information
pre-miRNA hsa-mir-637   
Genomic Coordinates chr19: 3961414 - 3961512
Synonyms MIRN637, hsa-mir-637, MIR637
Description Homo sapiens miR-637 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-637
Sequence 61| ACUGGGGGCUUUCGGGCUCUGCGU |84
Evidence Experimental
Experiments SAGE
Expression Profile
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN518997 2 COSMIC
COSN1082357 6 COSMIC
COSN13804010 13 COSMIC
COSN1082358 14 COSMIC
COSN30450169 14 COSMIC
COSN30532059 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1416171403 2 dbSNP
rs200224173 4 dbSNP
rs1475121792 9 dbSNP
rs202144891 13 dbSNP
rs767027646 14 dbSNP
rs529226642 16 dbSNP
rs751534327 17 dbSNP
rs758718359 17 dbSNP
rs149472696 20 dbSNP
rs773105166 21 dbSNP
rs543903246 22 dbSNP
rs374248027 24 dbSNP
Putative Targets

Gene Information
Gene Symbol SP7   
Synonyms OI11, OI12, OSX, osterix
Description Sp7 transcription factor
Transcript NM_001173467   
Other Transcripts NM_152860   
Expression
Putative miRNA Targets on SP7
3'UTR of SP7
(miRNA target sites are highlighted)		 
>SP7|NM_001173467|3'UTR
   1 GCCGGGTGGAAGGTCTCCCACCCCAGGGCTGCCCTGACAGTCTCTCTTGGCTCTCTAGACCACTGCTTGCCAATCACTCT
  81 CTTTACCCCATGCATGCCATCCTTCGGGGCTCTCTCCCTCTGTCTCCCTCCTGGCCATTCTGGGCTTGGGTATCTCCTTG
 161 CATGCCTCCTCAGCTCACCTTCTCTCTTCACCATGAGACTGGCTTTCCACAAACTCTCATCTCAGGCCCTCCCCTTGTGC
 241 CTGATACCTGCACTCCGGCTTCCTAGACTCTGGCCCTGCCACACCAACACACTTTCTATTTGGGCTCCCAACACTATTTC
 321 TCCATCTCACTCCTTGACATGTACCCCTTTCTGCTTCTCAAGCTTATTTCCTGCTGTCCCTCAGCCTCCAGGCTTCAGTC
 401 TTCCCAACTTCTTACACCATTGCTTTCCATTCTCCAGAACTCTTTTTTCCTTTTTACAAACACAATGATAATGATAATTT
 481 ATTGCCCCCTGGTGGCCTCTTCATCAGGGGTATTGGGGTTAGTGACCTGGCCAGAGGGTGCCAAGAGGGGGGCAGACCAG
 561 TGGGGATCTGATCCCAAAGATGGGGTGACCCCAGGGTCAGGGAGGCTGCCCCCAGGCCTGTATATTTAACCCCTATGTAC
 641 CAGGAGTAATGAATAGTAATAATTCTATTTATGTAAGTTATGATGACGGGTCAGGTAGAGTGAGCTGGGGAGGGAAGTGG
 721 ATCCATTTCTGCTAAGGAAATTCTAGTCAAATGCATCTCTGTATAGACAAAATGTTAGTGGAGAAGATCTTGTTAATAGA
 801 ATGTCTATCATCAGAATCTCAGTTGATAGGGTTTCTCTTGTAATGAAGTCTCTACAAATTGGGTTAGCTACATCTCTGCT
 881 AAACAGTTGATGGGGTATCTCTTGATTAGGGGGATCCCTAATATCCCCAGCCCCAGCCAGAAGCTGTGAAACCTCAAGTC
 961 CTATGGAGGGGAGAAGGACTGGAATGTACCCCATCTCCCTTGACTGCAGAGCAGGTTCCTCCACTGCCCCACCCCTTAGA
1041 CACCATGACCCCATCAGGTTAATCCCCTGTTGCCATGGTTATGGAGAGCTTGCAGCTGCCATCTTAGATGTGCTCTTTGG
1121 GGAAGCCCATCTAACAGGAGGACATTGGTTTGGGGGTGCACCTCCTGAAGAATGGGTGGGGAAGGCTTTCTCTAGGATCA
1201 GATTCAAATAAGTATGTATTGAGTGCCTACTCTGTGCAAGGCACTATGCTAGATCTGGTGCCTAGAAGCCCTGAGAAAGA
1281 ACTTAAAGAGCTAGGAGGACAGAGGCCCCCAAGCTGATCTGGTGGTGCATCCACGCACCCCCACCCTGGGACTTTGGATG
1361 CTCCCATCTCCACCTCCAGTGACTTTTAAAGCCGCTTCGTGCCTTTCCTGTAACGTTGGATCCTCCTTTTCTGTCCCCTG
1441 CTGTCTCAAGGCCCCAAGTTAAAGGGTTAAAGCCGCTGGAGCTTGGGGAGAGAACATTGTGGAATGGAAGGGATCATGCC
1521 CTTTGTGGAGTCTTTTTTTTTTAATTTAATAAATAAAAGTTGGATTTGAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugcGUCUCGGGCUUU----CGGGGGUCa 5'
             |||:|:| |::|    |||||||| 
Target 5' cccCAGGGTCAGGGAGGCTGCCCCCAGg 3'
 589 - 616 167.00 -27.50
2 
miRNA  3' ugCGUCUCGGGCUUUCGGGGGUCa 5'
            | :|| ||| ||  :|||||| 
Target 5' agGGGGATCCCTAATATCCCCAGc 3'
 908 - 931 150.00 -21.20
3 
miRNA  3' ugcgUCUCGGGCUUUCGGGGGUca 5'
              :|||  | :|:|||||||  
Target 5' gctaGGAGGACAGAGGCCCCCAag 3'
 1290 - 1313 144.00 -21.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
284957 4 ClinVar
309759 59 ClinVar
309757 414 ClinVar
COSN30154938 12 COSMIC
COSN15663798 20 COSMIC
COSN30513225 47 COSMIC
COSN31522059 63 COSMIC
COSN19680329 127 COSMIC
COSN28875899 147 COSMIC
COSN27278360 233 COSMIC
COSN31587930 506 COSMIC
COSN31531955 546 COSMIC
COSN24304230 557 COSMIC
COSN29338103 830 COSMIC
COSN26563512 899 COSMIC
COSN30538202 1012 COSMIC
COSN20109609 1209 COSMIC
COSN19385324 1323 COSMIC
COSN26650236 1352 COSMIC
COSN26504605 1482 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs374801698 3 dbSNP
rs115168998 4 dbSNP
rs1388216333 7 dbSNP
rs775226643 8 dbSNP
rs762123555 11 dbSNP
rs764210792 12 dbSNP
rs1417359744 15 dbSNP
rs763440084 16 dbSNP
rs1159198698 17 dbSNP
rs776048061 20 dbSNP
rs770342298 24 dbSNP
rs759763357 27 dbSNP
rs1435184022 28 dbSNP
rs777077547 30 dbSNP
rs771586553 31 dbSNP
rs747844132 32 dbSNP
rs1290775480 39 dbSNP
rs544948173 40 dbSNP
rs1217991731 41 dbSNP
rs1232792528 43 dbSNP
rs1344915462 47 dbSNP
rs1293976424 49 dbSNP
rs1358805427 50 dbSNP
rs938687310 51 dbSNP
rs140159335 59 dbSNP
rs1272472348 84 dbSNP
rs762991878 88 dbSNP
rs77121517 97 dbSNP
rs1003395141 101 dbSNP
rs750464590 105 dbSNP
rs1253957301 106 dbSNP
rs1484634206 107 dbSNP
rs1219846028 110 dbSNP
rs1308870576 112 dbSNP
rs961309369 115 dbSNP
rs909789382 126 dbSNP
rs983941700 139 dbSNP
rs1214382330 144 dbSNP
rs796785402 148 dbSNP
rs1285816280 149 dbSNP
rs953856489 150 dbSNP
rs147957989 155 dbSNP
rs570558773 162 dbSNP
rs1345013600 170 dbSNP
rs1301348482 178 dbSNP
rs997911442 179 dbSNP
rs1414688496 184 dbSNP
rs965420663 187 dbSNP
rs1313956261 188 dbSNP
rs1444410257 190 dbSNP
rs1024251262 193 dbSNP
rs1355373830 194 dbSNP
rs1340298542 197 dbSNP
rs1228925670 198 dbSNP
rs1276506957 206 dbSNP
rs1169930507 215 dbSNP
rs1345714891 219 dbSNP
rs1055629078 226 dbSNP
rs1256692181 233 dbSNP
rs894476578 241 dbSNP
rs764881181 245 dbSNP
rs941462578 247 dbSNP
rs1449692777 248 dbSNP
rs1031375508 253 dbSNP
rs759253533 255 dbSNP
rs887257567 256 dbSNP
rs1480703550 257 dbSNP
rs765469232 259 dbSNP
rs1404923419 260 dbSNP
rs904807638 261 dbSNP
rs1196677493 268 dbSNP
rs1327318333 275 dbSNP
rs1021869250 298 dbSNP
rs1301452574 299 dbSNP
rs1233103862 304 dbSNP
rs1233229032 307 dbSNP
rs573883884 310 dbSNP
rs1346997712 336 dbSNP
rs922888862 340 dbSNP
rs1013111643 341 dbSNP
rs1282920824 344 dbSNP
rs894607017 348 dbSNP
rs1190113778 362 dbSNP
rs114074384 374 dbSNP
rs1454127365 377 dbSNP
rs1200001575 379 dbSNP
rs540343934 386 dbSNP
rs1452260628 397 dbSNP
rs1265354116 406 dbSNP
rs1389486951 412 dbSNP
rs1458828776 413 dbSNP
rs552600157 414 dbSNP
rs1323483275 415 dbSNP
rs761195831 418 dbSNP
rs1439944906 420 dbSNP
rs956478539 444 dbSNP
rs1332818571 448 dbSNP
rs1236804290 458 dbSNP
rs1278811947 463 dbSNP
rs1030775948 465 dbSNP
rs1281890755 466 dbSNP
rs1270939570 467 dbSNP
rs1467730843 470 dbSNP
rs938817126 475 dbSNP
rs1269902431 478 dbSNP
rs112778209 479 dbSNP
rs776868259 487 dbSNP
rs942017653 491 dbSNP
rs909820636 492 dbSNP
rs1162840796 500 dbSNP
rs1394106832 501 dbSNP
rs983974245 509 dbSNP
rs1017375634 519 dbSNP
rs1338428599 523 dbSNP
rs1005622516 528 dbSNP
rs932494359 530 dbSNP
rs886049659 538 dbSNP
rs1470079037 543 dbSNP
rs886049658 547 dbSNP
rs1428552293 557 dbSNP
rs887225254 565 dbSNP
rs1333780565 567 dbSNP
rs1245085395 575 dbSNP
rs921066976 579 dbSNP
rs1173785574 606 dbSNP
rs934109423 608 dbSNP
rs144784638 620 dbSNP
rs1039927117 621 dbSNP
rs965193308 623 dbSNP
rs1185970413 633 dbSNP
rs557715621 635 dbSNP
rs942964163 636 dbSNP
rs1371500254 648 dbSNP
rs1460316895 650 dbSNP
rs1167697488 667 dbSNP
rs1371164920 677 dbSNP
rs1411576708 678 dbSNP
rs914894173 685 dbSNP
rs1377813363 686 dbSNP
rs977111513 687 dbSNP
rs1204749754 688 dbSNP
rs1461100999 701 dbSNP
rs1261834454 712 dbSNP
rs1314461007 713 dbSNP
rs1305368272 716 dbSNP
rs1241784101 723 dbSNP
rs989577751 759 dbSNP
rs1317660247 761 dbSNP
rs935072848 764 dbSNP
rs1222329758 773 dbSNP
rs923730492 776 dbSNP
rs1483631144 778 dbSNP
rs981827548 780 dbSNP
rs1259965367 782 dbSNP
rs539098187 797 dbSNP
rs771441440 799 dbSNP
rs1315947436 804 dbSNP
rs1428140831 808 dbSNP
rs1021900481 815 dbSNP
rs1187764269 820 dbSNP
rs1013132867 831 dbSNP
rs1453105712 837 dbSNP
rs1171721452 842 dbSNP
rs916420814 844 dbSNP
rs894713904 857 dbSNP
rs1405009837 862 dbSNP
rs1359502064 878 dbSNP
rs1433919729 884 dbSNP
rs1297789653 890 dbSNP
rs1301087626 893 dbSNP
rs772418751 896 dbSNP
rs578192030 902 dbSNP
rs1232482275 905 dbSNP
rs1455256650 914 dbSNP
rs1035894582 924 dbSNP
rs1345321625 933 dbSNP
rs776540317 935 dbSNP
rs963657423 939 dbSNP
rs1485553666 944 dbSNP
rs1003438626 946 dbSNP
rs760108542 948 dbSNP
rs1386716353 963 dbSNP
rs1295963481 964 dbSNP
rs1451124731 969 dbSNP
rs1191493460 970 dbSNP
rs1424426291 977 dbSNP
rs748539531 982 dbSNP
rs556489043 985 dbSNP
rs774762809 989 dbSNP
rs1342930585 992 dbSNP
rs1036381386 1000 dbSNP
rs1183764078 1002 dbSNP
rs1444462470 1015 dbSNP
rs1320831571 1019 dbSNP
rs942048946 1031 dbSNP
rs190155976 1032 dbSNP
rs1207455102 1033 dbSNP
rs1439211817 1036 dbSNP
rs1486468524 1037 dbSNP
rs774916654 1039 dbSNP
rs887745848 1045 dbSNP
rs886049657 1052 dbSNP
rs148781361 1058 dbSNP
rs768993148 1064 dbSNP
rs1361598077 1065 dbSNP
rs1305413795 1078 dbSNP
rs549032356 1085 dbSNP
rs1292799156 1088 dbSNP
rs921172900 1089 dbSNP
rs1209389925 1091 dbSNP
rs1245514389 1096 dbSNP
rs976636265 1110 dbSNP
rs1219175751 1112 dbSNP
rs1310283984 1115 dbSNP
rs1488644641 1120 dbSNP
rs1383653082 1156 dbSNP
rs552410040 1159 dbSNP
rs1362608692 1160 dbSNP
rs886049656 1161 dbSNP
rs1417331923 1185 dbSNP
rs977142879 1189 dbSNP
rs968384001 1192 dbSNP
rs1040299334 1193 dbSNP
rs1021337571 1196 dbSNP
rs199953520 1205 dbSNP
rs201601977 1208 dbSNP
rs200897296 1209 dbSNP
rs869168797 1209 dbSNP
rs1366875683 1210 dbSNP
rs199604150 1212 dbSNP
rs4020526 1212 dbSNP
rs71850349 1212 dbSNP
rs150786200 1215 dbSNP
rs1423575561 1216 dbSNP
rs991152949 1219 dbSNP
rs959012136 1227 dbSNP
rs1296986073 1231 dbSNP
rs143950478 1234 dbSNP
rs886049655 1252 dbSNP
rs1290290878 1255 dbSNP
rs1261648303 1256 dbSNP
rs749558452 1257 dbSNP
rs1332691920 1260 dbSNP
rs1227960807 1261 dbSNP
rs149491897 1268 dbSNP
rs551741868 1275 dbSNP
rs533217329 1280 dbSNP
rs1053451651 1281 dbSNP
rs769055750 1284 dbSNP
rs1249578214 1293 dbSNP
rs934956606 1293 dbSNP
rs1014965065 1299 dbSNP
rs923615970 1304 dbSNP
rs1490877682 1321 dbSNP
rs1253364245 1327 dbSNP
rs1006228626 1331 dbSNP
rs887854107 1334 dbSNP
rs1162317248 1339 dbSNP
rs879487433 1340 dbSNP
rs139022342 1341 dbSNP
rs996561664 1342 dbSNP
rs916405608 1350 dbSNP
rs886049654 1366 dbSNP
rs1370557060 1367 dbSNP
rs71455244 1374 dbSNP
rs780155753 1376 dbSNP
rs541864731 1381 dbSNP
rs1354533654 1393 dbSNP
rs769782519 1394 dbSNP
rs1447319951 1396 dbSNP
rs550900909 1399 dbSNP
rs943901841 1403 dbSNP
rs1229343413 1407 dbSNP
rs1307798645 1408 dbSNP
rs924398492 1412 dbSNP
rs529062157 1414 dbSNP
rs1341128076 1415 dbSNP
rs1205790892 1417 dbSNP
rs909084395 1418 dbSNP
rs1041568263 1421 dbSNP
rs951330488 1425 dbSNP
rs947160803 1426 dbSNP
rs146173431 1436 dbSNP
rs1467370401 1437 dbSNP
rs1389949506 1447 dbSNP
rs991201561 1452 dbSNP
rs777575032 1458 dbSNP
rs1171056305 1465 dbSNP
rs1374152772 1466 dbSNP
rs958588337 1473 dbSNP
rs1403745231 1477 dbSNP
rs1342545367 1482 dbSNP
rs1018434178 1497 dbSNP
rs928922075 1508 dbSNP
rs982062585 1512 dbSNP
rs962244842 1517 dbSNP
rs1053928636 1521 dbSNP
rs1462827081 1523 dbSNP
rs999752264 1525 dbSNP
rs878991611 1530 dbSNP
rs186222773 1541 dbSNP
rs376150058 1542 dbSNP
rs1190873277 1543 dbSNP
rs377039350 1543 dbSNP
rs952153045 1543 dbSNP
rs949134004 1551 dbSNP
rs1477980035 1560 dbSNP
rs373872272 1563 dbSNP
rs1270166970 1569 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions hMSC
Disease osteoporosis
Location of target site 3'UTR
Tools used in this research miRanda , TargetScan
Original Description (Extracted from the article) ... Osterix was a direct target of miR-637 in hMSCs ...

- Zhang JF; Fu WM; He ML; Wang H; Wang WM; Yu et al., 2011, Molecular biology of the cell.

Article - Zhang JF; Fu WM; He ML; Wang H; Wang WM; Yu et al.
- Molecular biology of the cell, 2011
Bone development is dynamically regulated by homeostasis, in which a balance between adipocytes and osteoblasts is maintained. Disruption of this differentiation balance leads to various bone-related metabolic diseases, including osteoporosis. In the present study, a primate-specific microRNA (miR-637) was found to be involved in the differentiation of human mesenchymal stem cells (hMSCs). Our preliminary data indicated that miR-637 suppressed the growth of hMSCs and induced S-phase arrest. Expression of miR-637 was increased during adipocyte differentiation (AD), whereas it was decreased during osteoblast differentiation (OS), which suggests miR-637 could act as a mediator of adipoosteogenic differentiation. Osterix (Osx), a significant transcription factor of osteoblasts, was shown to be a direct target of miR-637, which significantly enhanced AD and suppressed OS in hMSCs through direct suppression of Osx expression. Furthermore, miR-637 also significantly enhanced de novo adipogenesis in nude mice. In conclusion, our data indicated that the expression of miR-637 was indispensable for maintaining the balance of adipocytes and osteoblasts. Disruption of miR-637 expression patterns leads to irreversible damage to the balance of differentiation in bone marrow.
LinkOut: [PMID: 21880893]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.417 2.1e-2 0.413 2.2e-2 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.305 6.9e-2 -0.189 1.8e-1 25 Click to see details
GSE28260 Renal cortex and medulla -0.312 1.5e-1 -0.077 4.0e-1 13 Click to see details
GSE26953 Aortic valvular endothelial cells 0.21 1.6e-1 0.109 3.1e-1 24 Click to see details
GSE32688 Pancreatic cancer 0.087 3.2e-1 0.088 3.2e-1 32 Click to see details
GSE27834 Pluripotent stem cells -0.125 3.2e-1 0.100 3.6e-1 16 Click to see details
GSE17306 Multiple myeloma 0.048 3.7e-1 0.246 4.4e-2 49 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.063 4.0e-1 -0.072 3.8e-1 20 Click to see details
GSE38226 Liver fibrosis -0.054 4.1e-1 0.301 9.2e-2 21 Click to see details
GSE21687 Ependynoma primary tumors 0.016 4.5e-1 0.049 3.5e-1 64 Click to see details
GSE14794 Lymphoblastoid cells -0.004 4.9e-1 -0.017 4.4e-1 90 Click to see details
GSE14794 Lymphoblastoid cells -0.004 4.9e-1 -0.017 4.4e-1 90 Click to see details
GSE14794 Lymphoblastoid cells -0.004 4.9e-1 -0.017 4.4e-1 90 Click to see details
GSE14794 Lymphoblastoid cells -0.004 4.9e-1 -0.017 4.4e-1 90 Click to see details
GSE14794 Lymphoblastoid cells -0.004 4.9e-1 -0.017 4.4e-1 90 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-637 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006147 SP7 Sp7 transcription factor 3 1
MIRT054906 COL4A1 collagen type IV alpha 1 chain 1 1
MIRT159142 NRBP1 nuclear receptor binding protein 1 2 2
MIRT358526 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2 2
MIRT441490 NCEH1 neutral cholesterol ester hydrolase 1 2 2
MIRT443472 ACPP acid phosphatase, prostate 2 2
MIRT464631 UBE4A ubiquitination factor E4A 2 2
MIRT465259 TRIM44 tripartite motif containing 44 2 2
MIRT473975 LRRC58 leucine rich repeat containing 58 2 2
MIRT475168 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT477631 EFNA1 ephrin A1 2 2
MIRT480100 CALR calreticulin 2 2
MIRT483504 STMN3 stathmin 3 2 4
MIRT483735 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT483847 UNC5B unc-5 netrin receptor B 2 2
MIRT485973 RTBDN retbindin 2 2
MIRT486616 METTL6 methyltransferase like 6 2 2
MIRT487847 CLSTN1 calsyntenin 1 2 4
MIRT488675 WWP2 WW domain containing E3 ubiquitin protein ligase 2 2 4
MIRT489046 PRPF4B pre-mRNA processing factor 4B 2 2
MIRT490612 SLC47A1 solute carrier family 47 member 1 2 4
MIRT490990 USP22 ubiquitin specific peptidase 22 2 2
MIRT492559 PRX periaxin 2 2
MIRT494667 ARL8A ADP ribosylation factor like GTPase 8A 2 2
MIRT495880 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT496778 ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 2 2
MIRT499742 USH1G USH1 protein network component sans 2 4
MIRT500371 ZNF385A zinc finger protein 385A 2 2
MIRT503257 KIF18B kinesin family member 18B 2 2
MIRT504511 PPP1R9B protein phosphatase 1 regulatory subunit 9B 2 2
MIRT511940 FAM127B retrotransposon Gag like 8A 2 2
MIRT514606 NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 2 4
MIRT527187 CLASP1 cytoplasmic linker associated protein 1 2 2
MIRT532494 HOXA13 homeobox A13 2 2
MIRT533504 TRIM71 tripartite motif containing 71 2 2
MIRT539171 AR androgen receptor 2 2
MIRT542735 RBFOX2 RNA binding protein, fox-1 homolog 2 2 2
MIRT544647 PHF8 PHD finger protein 8 2 4
MIRT546232 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 2
MIRT548372 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 4
MIRT555913 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT565381 TGOLN2 trans-golgi network protein 2 2 2
MIRT568954 RUNX3 runt related transcription factor 3 2 2
MIRT570205 RAP1GAP2 RAP1 GTPase activating protein 2 2 2
MIRT573599 CERS1 ceramide synthase 1 2 2
MIRT615364 CCNF cyclin F 2 2
MIRT616102 HOXB5 homeobox B5 2 2
MIRT619127 CD40LG CD40 ligand 2 2
MIRT634968 C8orf17 chromosome 8 open reading frame 17 2 2
MIRT646665 FNBP1 formin binding protein 1 2 2
MIRT649633 RASA4 RAS p21 protein activator 4 2 2
MIRT658443 FAM167B family with sequence similarity 167 member B 2 2
MIRT660237 BMP7 bone morphogenetic protein 7 2 2
MIRT669467 ATL3 atlastin GTPase 3 2 2
MIRT670557 SHISA2 shisa family member 2 2 2
MIRT671035 PCDHB2 protocadherin beta 2 2 2
MIRT684255 TBXA2R thromboxane A2 receptor 2 2
MIRT688619 CYBRD1 cytochrome b reductase 1 3 2
MIRT694346 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT695516 ALPI alkaline phosphatase, intestinal 2 2
MIRT697512 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT700133 RNF144B ring finger protein 144B 2 2
MIRT711667 TRMT5 tRNA methyltransferase 5 2 2
MIRT712156 TAOK1 TAO kinase 1 2 2
MIRT712463 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT720759 FAM193A family with sequence similarity 193 member A 2 2
MIRT731198 AKT1 AKT serine/threonine kinase 1 2 1
MIRT755463 PACS2 phosphofurin acidic cluster sorting protein 2 1 1
MIRT755522 FOXM1 forkhead box M1 3 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-637 Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma tissue
hsa-miR-637 Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-637 Cisplatin 5460033 NSC119875 approved sensitive Low Squamous Cell Carcinoma cell line (SCC-11)
hsa-miR-637 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-637 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-637 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (50nM)
hsa-miR-637 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (50nM)
hsa-miR-637 Tivantinib 11494412 NSC758242 resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-637 Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (HT-29, HCT-116)
hsa-miR-637 Sevoflurane 5206 NSC760367 approved sensitive Low Colorectal Cancer cell line
hsa-mir-637 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-637 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-mir-637 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-637 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-637 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-637 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-637 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-637 Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-637 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-637 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-637 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-637 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-637 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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