pre-miRNA Information | |
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pre-miRNA | hsa-mir-92a-1 |
Genomic Coordinates | chr13: 91351314 - 91351391 |
Synonyms | MIR92-1, MIRN92-1, MIRN92A-1, MIRN92A1, miRNA92-1, MIR92A1 |
Description | Homo sapiens miR-92a-1 stem-loop |
Comment | Human miR-92a (previously named miR-92 here) has two predicted hairpin precursor sequences: mir-92a-1 (MIR:MI0000093) on chromosome 13 (named mir-92-13 in . |
RNA Secondary Structure | |
Associated Diseases | |
pre-miRNA | hsa-mir-92a-2 |
Genomic Coordinates | chrX: 134169538 - 134169612 |
Synonyms | MIRN92-2, MIRN92A-2, MIRN92A2, MIR92A2 |
Description | Homo sapiens miR-92a-2 stem-loop |
Comment | Human miR-92a (previously named miR-92 here) has two predicted hairpin precursor sequences: mir-92a-1 (MIR:MI0000093) on chromosome 13 (named mir-92-13 in . |
RNA Secondary Structure | |
Associated Diseases |
Mature miRNA Information | ||||||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-92a-3p | |||||||||||||||||||||||||||||||||
Sequence | 48| UAUUGCACUUGUCCCGGCCUGU |69 | |||||||||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||||||||
Experiments | Cloned | |||||||||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Biomarker Information |
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Gene Information | |||||||||||||||||||||
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Gene Symbol | BCL2L11 | ||||||||||||||||||||
Synonyms | BAM, BIM, BOD | ||||||||||||||||||||
Description | BCL2 like 11 | ||||||||||||||||||||
Transcript | NM_006538 | ||||||||||||||||||||
Other Transcripts | NM_138621 , NM_207002 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on BCL2L11 | |||||||||||||||||||||
3'UTR of BCL2L11 (miRNA target sites are highlighted) |
>BCL2L11|NM_006538|3'UTR 1 CAGGTTCTTTGCGGAGCCGAGATACCATGCAGACATTTTGCTTGTTCAAACCAACAAGACCCAGCACCGCGGTCTCCTGG 81 TGCCATTATTATGCAGCCAGCGGTTCTCTTGTGGAGGGGGCAGGTGACGTTTCAGAAGACACCGAGCTGGATGGGACTAC 161 CTTTCTGTTCATCACCACACAGCAGAATTTCTAATGGAAGTTTGTTGTGAATGTAAAGGAGGGAGCATTCTTTGCTTTTT 241 AATATACAAACCATGGTTTTTTGGAGCAGGATTTTGTGTAAGAATGGTGTTTACATGCAGTGTGTTTTCCCCCTCACCTT 321 CAATAAGGTTTTTCAAAAAGGAAATGGAAACTTTTTAACCAATTTGTGAATAACTTTTGTATTAAAATTTTAAGAACCTA 401 CGGCCTATTCTCAGAGGATTATGTAACCCCTGCAGTGGAAACTGAGCCAGCTAACTTAAAAAGCTGCCTTAGTTTATTTT 481 TAGAGATTACAGAATTTTTAAACAGGGAGACGTGTGATATACTCCCTCCCTTCCCTACTATTGCCTCTCTGACCTTTTTA 561 AATTATTTTTAATACCAAAAGAGTTCTTTTGAAATGGAACTGATTAAAAGGGCAGAGGGTCTGTTGCCAGCCTGCATTGA 641 TATACCAGTCCCATTTGTAAATATTTACGTACCTTTATAAATTCAGTTGCATCTGTGGCAAAATTTCAGACTATTTTTGC 721 GTCTTTCCTCATCACTTTTTGTGATGCAACTCCAGTCTGGACTCAGATGCATAGATTTGGTCCAGTGTATTTTCATGATA 801 AAGTGAAATTGAGTCAGAACAAGAGTTAATATCTGCCTGTATCTTGCACAGTTCGAGCGATCTGTTATTAACTGGGAAGC 881 ATTTGGTGTTGGTTTTCATTCCATTTCGACGAGCATGTTATTGGGAAGTATTCTGAAGAGGCAATAGCAGTAATAACAAC 961 AGACTTAAGTGCTACGCCCCTTTGTGCTGCTGGCTTTTCTGGTTGCAGGCTTTCCCATGGTCACAGGATGCACTGTCAGC 1041 ATCAGGTCCCAGAGGGCCACCGTGTCCATTACAGCAGAGTCCAGCTGCAGCATCCAGCTCACGCCCTCATGGGAATTGGC 1121 ACAGGCCTGGGGCAGGGCTTCTGATGGCCATTTGCTTGGCCTCCTGCATTTTAGTCCAACTCACAGTCCACTAGCTTCAC 1201 TCCTTTAAATTCACTTTGAAACAGGCCTCATCCCACTTCCACCAGCACCATAGAAGAATAATTCTGGGCAGAAGTCTGTT 1281 TTTTTTCATTTTTCCAGGACAGTTGGATATTGTCAGGCCACTTGTGACCCCAGCCATGTAGTGAGGGTGCTCTTTCTCTG 1361 TGCCTGCTCCTTATGAGTGCAGTGGAAGGAAGCCACACACTGGTCAGTCATTTCAGAGGCAGCAGATGCCCAGGGAGACC 1441 CAAGAAAGAGTCAGGTTAGGGAGCAGTGAAAGTGAGGAGGGAAGACAATTCTGTGAACTCTGTAACTCTTAAAATTTTTG 1521 AAAACTCCATCGTTAAACAACTTTTAAAAGAAATAACTAAATTTTCAAATGAGTAAGCAGTGCCACCAACTAGTGTTTTG 1601 CCCGATAGAAGAGCCAGCATGTTCACGTTATTTAAATTAGGTGGAAAAATCTAAACATTTTTATCTTCATAATTTAAAAA 1681 ATATATATGTATATATTGCATATTCACTTTTTCCTTTAGGTAGAGATGATTTCAATCCAAATACTCTTACTTTAAAAAAT 1761 TTCCTTTCCCCAAGAATCTCCTTGGGACTTTGACTTATTTTTAAAGCTGTGTTGGAGCTCATCTTGTTCCCTGATGTGTC 1841 TCGAGCCCATTGGTAGGGTCATACAAAGCCCACGGTTACAAGCAGTGGTAGGATTGCAGCCGTGGGCCTGCTGGACACAC 1921 ACATACACCAAAGATGTATTTGGATCTGGGCACCCCCTCCCAGGATCCCTGTACTCACGTGCCAGTCTCCTGACTAGAGC 2001 ACTTTACTCTGTTTCCTCAGCCCTGCAGCCCCTGGGAGCACACACTGGGTGCAGCCCTGGGCCAGGCACGGGAGGCCCTG 2081 CCCTGTGCTGCCCAGGGGCTGTGTGCACCACATGAGCACATTTCCCTCTGGCCTGGCGGCCTCCAGGCTGGCTGTGGAAA 2161 CAGTTCCTGAGGAAATTAGAGATTCTATGAATTGTAGGAGTATTAAAGACCAGGCTGTTGGCACCAGAACTTAAAGCGAT 2241 GACTGGATGTCTCTGTACTGTATGTATCTGGTTATCAAGATGCCTCTGTGCAGAAAGTATGCCTCCCGTGGGTATACGTT 2321 TTTACCTTTTTTAAAAAACATTTTTGTAGAAAAAATAATTAAATCCCCTTTTTGGAAACTTACTGCAGGTTTTGTGCCTT 2401 GACAACCTCTCCCTATGTGAGGTTTGTAAAAAGTGTCCTGTGACTTAACACAGAAACGCAATAAACACACACAAAATAGT 2481 TTCATGAGTGATTCTTCAGATGCCCTTCCCAACTGGTTAGTTGATCAAGAATTTTGGGGGTGGGGGTTGCGGAGAAATCA 2561 AGTTTAAAATTCCTTCTGATTAAAAAAATATAGTGGAATACAATTGTCTGCCGTTTCCCCTTCTTAATGTATATATTGTG 2641 AGTATTTATTAGATTCGTAGGTCATATTACTTATCAACTGAGCCAAATGTCTGTGTGCAATTGTGTTTCCTTTACCTTGT 2721 AAAATTTTGTACAGCATAAATAAGTAAAAAAATCACTGTTTTTCTCAACTTTTTCAAAATCAAGGATTGTAAATATTGTA 2801 GATTCTTTTTCTGTGTGATGTGTCCTACTGTTTCATAATGCTGTAACTTGTAGAAATATTGTATATTTATTTTCTGCTTA 2881 TTTAATGTCTTAATTTCTGAAAAGTATTAACATCCCTGTCTCCCACTCCCCTGCCGTCCCATGAAGTTAACTCCTGAGAG 2961 TTGTCGGGGGTGACTGGAGAGCTCATTGCAGACCACGTGGTCCTCCAGGGTGGCTCTCCACCTTCGGGTCCTGGTATTTC 3041 CAGTCAAGTGGGTTTCAATTCTTGGGCTTTGCCGCCCTTATGATGAAGTGTGTGTTTGATGCCAGTGAGAAACTCAGTCT 3121 GGCAGGCTACAAAATTCTACTCCAAGAAATACCCAGCAACCTTCTGTTTGTTCCAAAGCAACTAGCTTATCATGCAAGCA 3201 AATTTTGCTGACTCCAGGCTTTATCTTTAGGAAAACAAAAAAACCAAAGTATTATCAGCAGGTGGGAAAGATTTTTCTAT 3281 TGAAAATTTATCCCTGACAACTCAGCGTTTAGAAAAGAAATAAAATGTGCCACTTCCAGAGGTGCTGCATTGCAGTTGTT 3361 CAGGGCTAGGGCCAGGCAGGACAAGTGAATGGGTGGGACAGGTGGCTCCTGCCTAAGGACCACCTCAGGCCACTAACCCC 3441 TTGTGGACAACTGTGAGTAGCTGGGTTTTCCCCCACCTGCTGTGCAACTTCCTGTGCTTTGAGGTTGGACTAACTTGTCT 3521 TCAGGAGCTAATTAACTGTACAGCCCTCCCCACGCCCCACCCATACGGTCACTGCATTTGGTCAGCCTGCTTCTTCAGGT 3601 CGATGCCCTCCTTCTGATACTCCATCTCCTTCAGGGGAGGTTGGGGCCCCACTGGACTGGGTGTCAAGATGTGAAAGCTT 3681 ATGGGAGCTTTAAGGAGACTTCATGGTGGTTCCATGCAGGTGGTTCTGCCATCCCTGCTGATTTAGCCTGGTGCCTGTGT 3761 GTGTCCACTCACGTACACGTGGGGTGGGGGAAACGTGTCTACAGATGACGCTAAATCAGTTGGGGTCTACTCTAAACAGC 3841 ATTGTGTGTAAGAAGCATCCTCAAGCTCCCAGTTAAGTAACTTGACTACTTTTATTTGGGAATTTCAGACTATAGAAGCT 3921 CTCTTATGTTTTATGTCCAGATTCTGTGACCACTAGTTACTGTATCAGAACTCATCAGGTACCCACTTATAAATAGCACT 4001 GATCTGGCTGTATACTGATCCATCACTAACCTGTTTTCTAGGACCCAGCGTATGTAGCATTTGTATTGCAGTTTCCCTGG 4081 CTTACTTGTGTTTTGCACTGATGAATTTTGACAGGGTAATTGCCACTTTACTTGTGCAATACTGCTGTAAATAACTGCAG 4161 ATTTTTAAACAATCTTTTATGTTAATTTTATAAAAATAAAACTTTCAACTAGTTAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control
PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control
PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection
PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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Experimental Support 2 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Disease | 10018.0 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"HITS-CLIP data was present in GSM714642. RNA binding protein: AGO2. Condition:completeT1
"PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1
... - Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods. |
Article |
- Kishore S; Jaskiewicz L; Burger L; Hausser et al. - Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
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Experimental Support 3 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | SW480 |
Disease | colorectal cancer |
Location of target site | 3'UTR |
Tools used in this research | Unspecified |
Original Description (Extracted from the article) |
...
miR-92a directly targeted the anti-apoptotic molecule BCL-2-interacting mediator of cell death (BIM) in colon cancer tissues
... - Tsuchida A; Ohno S; Wu W; Borjigin N; et al., 2011, Cancer science. |
Article |
- Tsuchida A; Ohno S; Wu W; Borjigin N; et al. - Cancer science, 2011
MicroRNAs (miRNAs) belong to a class of endogenously expressed non-coding small RNAs that function primarily as gene regulators. Growing evidence suggests that miRNAs play a significant role in tumor development, making them potential biomarkers for cancer diagnosis and prognosis. The miR-17-92 cluster has emerged as an important locus, being highly overexpressed in several cancers in association with cancer development and progression. The miR-17-92 miRNA cluster generates a single polycistronic primary transcript that yields six mature miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b, and miR-92a. In colon cancer development, the pathophysiologic roles of these transcripts and their targets are largely unknown. In the present study, we performed copy number analyses of the six miRNAs transcribed from the miR-17-92 cluster in colon tumor tissues. We determined that miR-92a was transcribed at higher levels than the other five miRNAs in both adenomas and carcinoma. In addition, miR-92a directly targeted the anti-apoptotic molecule BCL-2-interacting mediator of cell death (BIM) in colon cancer tissues. An anti-miR-92a antagomir induced apoptosis of colon cancer-derived cell lines. These data indicate that miR-92a plays a pivotal role in the development of colorectal carcinoma.
LinkOut: [PMID: 21883694]
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Experimental Support 4 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | Jiyoye |
Tools used in this research | TargetScan |
Original Description (Extracted from the article) |
...
HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO2.
... - Riley KJ; Rabinowitz GS; Yario TA; Luna JM; et al., 2012, The EMBO journal. |
Article |
- Riley KJ; Rabinowitz GS; Yario TA; Luna JM; et al. - The EMBO journal, 2012
Epstein-Barr virus (EBV) controls gene expression to transform human B cells and maintain viral latency. High-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) identified mRNA targets of 44 EBV and 310 human microRNAs (miRNAs) in Jijoye (Latency III) EBV-transformed B cells. While 25% of total cellular miRNAs are viral, only three viral mRNAs, all latent transcripts, are targeted. Thus, miRNAs do not control the latent/lytic switch by targeting EBV lytic genes. Unexpectedly, 90% of the 1664 human 3'-untranslated regions targeted by the 12 most abundant EBV miRNAs are also targeted by human miRNAs via distinct binding sites. Half of these are targets of the oncogenic miR-17 approximately 92 miRNA cluster and associated families, including mRNAs that regulate transcription, apoptosis, Wnt signalling, and the cell cycle. Reporter assays confirmed the functionality of several EBV and miR-17 family miRNA-binding sites in EBV latent membrane protein 1 (LMP1), EBV BHRF1, and host CAPRIN2 mRNAs. Our extensive list of EBV and human miRNA targets implicates miRNAs in the control of EBV latency and illuminates viral miRNA function in general.
LinkOut: [PMID: 22473208]
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Experimental Support 5 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | U251 , U87 , LN229 , A172 |
Disease | glioblastoma |
Location of target site | 3'UTR |
Tools used in this research | miRanda , PicTar , TargetScan |
Original Description (Extracted from the article) |
...
Bim is a functional target of miR-92a.
... - Niu H; Wang K; Zhang A; Yang S; Song Z; et al., 2012, Oncology reports. |
Article |
- Niu H; Wang K; Zhang A; Yang S; Song Z; et al. - Oncology reports, 2012
Recent studies have revealed that miR-92a is overexpressed in several types of malignancies and provides a protumorigenic effect. Our findings demonstrate that the high expression of miR-92a in human glioma specimens is significantly correlated with low levels of BCL2L11 (Bim) protein and high-grade glioma. Here, we present the first evidence that miR-92a antisense oligonucleotide (AS-miR-92a) provides a tumor suppressive effect via induction of apoptosis in human glioma cells. In addition, we show that Bim is a direct functional target of miR-92a. Introducing Bim cDNA without 3'UTR abrogates miR-92a-induced cell survival. Further investigations will focus on the therapeutic use of AS-miR92a-mediated antitumor effects in glioma.
LinkOut: [PMID: 22895567]
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Experimental Support 6 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Disease | 10018.0 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine
"PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine
"PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
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Experimental Support 7 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | C8166 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3
... - Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio. |
Article |
- Whisnant AW; Bogerd HP; Flores O; Ho P; et al. - mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
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Experimental Support 8 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | Raji , MOLT4 , 293T |
Location of target site | 3'UTR |
Tools used in this research | microRNA.org |
Original Description (Extracted from the article) |
...
"The dual-luciferase reporter assay shows that miR-92a mimics reduced by 50% fluorescence activity of wt 30-UTR compared with the negative control (Figure 4B
... - Lv XB; Zhang X; Deng L; Jiang L; Meng W; Lu et al., 2014, Cell biology international. |
Article |
- Lv XB; Zhang X; Deng L; Jiang L; Meng W; Lu et al. - Cell biology international, 2014
AZD6244, an ATP-uncompetitive inhibitor of mitogen-activated protein kinase 1/2 (MEK1/2), has shown activity in several malignant tumours. However, whether AZD6244 has a function in lymphoma cells is not known. We report that AZD6244 treatment represses the growth of Raji and MOLT4 cells by inducing apoptosis and G1-phase arrest. Using miRNAs array and quantitative RT-PCR, miR-92a was downregulated byAZD6244 treatment through the ERK1/2-AP1 signalling pathway. Overexpression of miR-92a abrogated AZD6244-induced apoptosis and G1-phase arrest, indicating that it is involved in the cytotoxicity of AZD6244 in lymphoma cells. A luciferase reporter assay showed that miR-92a directly targetsthe 3'-UTRs of Bim. Overexpression of miR-92a mimics downregulated Bim mRNA and protein expression level, indicating that miR-92a negatively regulates its expression at both levels. Silencing Bim decreases AZD6244-induced apoptosis and G1-phase arrest, suggesting that Bim contributes to the growth arrest. Thus, miR-92a mediates AZD6244-induced cytotoxicity of lymphoma cells by targeting Bim. Downregulation of miR-92a by AZD6244 is mediated by the ERK1/2-AP1 signalling pathway.
LinkOut: [PMID: 24375836]
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Experimental Support 9 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
|
Conditions | HCT116 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1
PAR-CLIP data was present in ERX177611. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_1
PAR-CLIP data was present in ERX177615. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_5
PAR-CLIP data was present in ERX177616. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_6
PAR-CLIP data was present in ERX177623. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_1
PAR-CLIP data was present in ERX177627. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_5
PAR-CLIP data was present in ERX177631. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_9
PAR-CLIP data was present in ERX177603. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_5
... - Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research. |
Article |
- Krell J; Stebbing J; Carissimi C; Dabrowska et al. - Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
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CLIP-seq Support 1 for dataset GSM714642 | |
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Method / RBP | HITS-CLIP / AGO2 |
Cell line / Condition | HEK293 / completeT1, repA |
Location of target site | ENST00000393256.3 | 3UTR | AAUUUUGACAGGGUAAUUGCCACUUUACUUGUGCAAUACUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21572407 / GSE28865 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM545212 | |
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Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / Control |
Location of target site | ENST00000393256.3 | 3UTR | CCACUUUACUUGUGCAAUACUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM545214 | |
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Method / RBP | PAR-CLIP / AGO3 |
Cell line / Condition | HEK293 / Control |
Location of target site | ENST00000393256.3 | 3UTR | AUUUUGACAGGGUAAUUGCCACUUUACUUGUGCAAUACU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
CLIP-seq Support 4 for dataset GSM545216 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / miR-124 transfection |
Location of target site | ENST00000393256.3 | 3UTR | AAUUUUGACAGGGUAAUUGCCACUUUACUUGUGCAAUACUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
CLIP-seq Support 5 for dataset GSM545217 | |
---|---|
Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / miR-7 transfection |
Location of target site | ENST00000393256.3 | 3UTR | CCACUUUACUUGUGCAAUACUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
CLIP-seq Support 6 for dataset GSM714645 | |
---|---|
Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / completeT1, repB |
Location of target site | ENST00000393256.3 | 3UTR | AUUUUGACAGGGUAAUUGCCACUUUACUUGUGCAAUACUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21572407 / GSE28865 |
CLIP-seq Viewer | Link |
CLIP-seq Support 7 for dataset GSM1065668 | |
---|---|
Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_7 |
Location of target site | ENST00000393256.3 | 3UTR | CCACUUUACUUGUGCAAUACU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
CLIP-seq Support 8 for dataset GSM1065669 | |
---|---|
Method / RBP | PAR-CLIP / AGO1 |
Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_8 |
Location of target site | ENST00000393256.3 | 3UTR | CCACUUUACUUGUGCAAUACUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
CLIP-seq Support 9 for dataset GSM1065670 | |
---|---|
Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / 4-thiouridine, 3_ML_LG |
Location of target site | ENST00000393256.3 | 3UTR | CCACUUUACUUGUGCAAUACU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23446348 / GSE43573 |
CLIP-seq Viewer | Link |
CLIP-seq Support 10 for dataset GSM1462572 | |
---|---|
Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | C8166 / C8166 NL4-3 |
Location of target site | ENST00000393256.3 | 3UTR | CCACUUUACUUGUGCAAUACUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 23592263 / GSE59944 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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MiRNA-Target Expression Profile (TCGA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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|
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT001199 | UVRAG | UV radiation resistance associated | 1 | 1 | ||||||||
MIRT003031 | ITGA5 | integrin subunit alpha 5 | 5 | 1 | ||||||||
MIRT004089 | ARID4B | AT-rich interaction domain 4B | 2 | 1 | ||||||||
MIRT004090 | HIPK3 | homeodomain interacting protein kinase 3 | 2 | 1 | ||||||||
MIRT004091 | MYLIP | myosin regulatory light chain interacting protein | 4 | 8 | ||||||||
MIRT004281 | TP63 | tumor protein p63 | 4 | 1 | ||||||||
MIRT004331 | KAT2B | lysine acetyltransferase 2B | 4 | 2 | ||||||||
MIRT004563 | ESR2 | estrogen receptor 2 | 2 | 1 | ||||||||
MIRT004737 | TGFBR2 | transforming growth factor beta receptor 2 | 4 | 2 | ||||||||
MIRT004932 | BMPR2 | bone morphogenetic protein receptor type 2 | 5 | 2 | ||||||||
MIRT005590 | CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 4 | 2 | ||||||||
MIRT005628 | THBS1 | thrombospondin 1 | 3 | 1 | ||||||||
MIRT005632 | SMAD4 | SMAD family member 4 | 2 | 1 | ||||||||
MIRT006029 | CDH1 | cadherin 1 | 2 | 1 | ||||||||
MIRT006148 | BCL2L11 | BCL2 like 11 | 5 | 12 | ||||||||
MIRT006372 | KLF2 | Kruppel like factor 2 | 2 | 1 | ||||||||
MIRT048915 | TPD52L3 | tumor protein D52 like 3 | 1 | 1 | ||||||||
MIRT048916 | TXLNA | taxilin alpha | 2 | 5 | ||||||||
MIRT048917 | NDST1 | N-deacetylase and N-sulfotransferase 1 | 1 | 1 | ||||||||
MIRT048918 | EFNB1 | ephrin B1 | 1 | 1 | ||||||||
MIRT048919 | RPL39 | ribosomal protein L39 | 1 | 1 | ||||||||
MIRT048920 | TMF1 | TATA element modulatory factor 1 | 2 | 10 | ||||||||
MIRT048921 | KCTD7 | potassium channel tetramerization domain containing 7 | 1 | 1 | ||||||||
MIRT048922 | VBP1 | VHL binding protein 1 | 1 | 1 | ||||||||
MIRT048923 | TPT1 | tumor protein, translationally-controlled 1 | 1 | 1 | ||||||||
MIRT048924 | TRAPPC13 | trafficking protein particle complex 13 | 1 | 1 | ||||||||
MIRT048925 | NEK2 | NIMA related kinase 2 | 1 | 1 | ||||||||
MIRT048926 | CYP7A1 | cytochrome P450 family 7 subfamily A member 1 | 1 | 1 | ||||||||
MIRT048927 | SLC25A3 | solute carrier family 25 member 3 | 1 | 1 | ||||||||
MIRT048928 | UCHL1 | ubiquitin C-terminal hydrolase L1 | 1 | 1 | ||||||||
MIRT048929 | RPS24 | ribosomal protein S24 | 1 | 1 | ||||||||
MIRT048930 | FAM83G | family with sequence similarity 83 member G | 1 | 1 | ||||||||
MIRT048931 | BCS1L | BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone | 1 | 1 | ||||||||
MIRT048932 | DTWD2 | DTW domain containing 2 | 1 | 1 | ||||||||
MIRT048933 | SLC20A1 | solute carrier family 20 member 1 | 1 | 1 | ||||||||
MIRT048934 | C1orf174 | chromosome 1 open reading frame 174 | 1 | 1 | ||||||||
MIRT048935 | CUX1 | cut like homeobox 1 | 2 | 1 | ||||||||
MIRT048936 | DDX23 | DEAD-box helicase 23 | 1 | 1 | ||||||||
MIRT048937 | PON2 | paraoxonase 2 | 1 | 1 | ||||||||
MIRT048938 | STK4 | serine/threonine kinase 4 | 1 | 1 | ||||||||
MIRT048939 | CHST9 | carbohydrate sulfotransferase 9 | 1 | 1 | ||||||||
MIRT048940 | SHISA5 | shisa family member 5 | 1 | 1 | ||||||||
MIRT048941 | CD3EAP | CD3e molecule associated protein | 1 | 1 | ||||||||
MIRT048942 | GCHFR | GTP cyclohydrolase I feedback regulator | 1 | 1 | ||||||||
MIRT048943 | DHX30 | DExH-box helicase 30 | 1 | 1 | ||||||||
MIRT048944 | CEP97 | centrosomal protein 97 | 1 | 1 | ||||||||
MIRT048945 | IPO4 | importin 4 | 1 | 1 | ||||||||
MIRT048946 | POLE | DNA polymerase epsilon, catalytic subunit | 1 | 1 | ||||||||
MIRT048947 | SETDB1 | SET domain bifurcated 1 | 1 | 1 | ||||||||
MIRT048948 | GABPA | GA binding protein transcription factor alpha subunit | 1 | 1 | ||||||||
MIRT048949 | ATAD3A | ATPase family, AAA domain containing 3A | 1 | 1 | ||||||||
MIRT048950 | HSD17B10 | hydroxysteroid 17-beta dehydrogenase 10 | 1 | 1 | ||||||||
MIRT048951 | TYMP | thymidine phosphorylase | 1 | 1 | ||||||||
MIRT048952 | CIT | citron rho-interacting serine/threonine kinase | 1 | 1 | ||||||||
MIRT048953 | IK | IK cytokine, down-regulator of HLA II | 1 | 1 | ||||||||
MIRT048954 | TFPI | tissue factor pathway inhibitor | 1 | 1 | ||||||||
MIRT048955 | CAMKV | CaM kinase like vesicle associated | 1 | 1 | ||||||||
MIRT048956 | QTRT1 | queuine tRNA-ribosyltransferase catalytic subunit 1 | 1 | 1 | ||||||||
MIRT048957 | ASAH1 | N-acylsphingosine amidohydrolase 1 | 1 | 1 | ||||||||
MIRT048958 | SAP30BP | SAP30 binding protein | 1 | 1 | ||||||||
MIRT048959 | RORA | RAR related orphan receptor A | 2 | 1 | ||||||||
MIRT048960 | ELAC2 | elaC ribonuclease Z 2 | 1 | 1 | ||||||||
MIRT048961 | HNRNPLL | heterogeneous nuclear ribonucleoprotein L like | 1 | 1 | ||||||||
MIRT048962 | ETV6 | ETS variant 6 | 1 | 1 | ||||||||
MIRT048963 | PRRC2B | proline rich coiled-coil 2B | 2 | 4 | ||||||||
MIRT048964 | LY6G5B | lymphocyte antigen 6 family member G5B | 1 | 1 | ||||||||
MIRT048965 | ALKBH4 | alkB homolog 4, lysine demethylase | 1 | 1 | ||||||||
MIRT048966 | DAZAP1 | DAZ associated protein 1 | 1 | 1 | ||||||||
MIRT048967 | IPO7 | importin 7 | 1 | 1 | ||||||||
MIRT048968 | CTC1 | CST telomere replication complex component 1 | 1 | 1 | ||||||||
MIRT048969 | CHCHD10 | coiled-coil-helix-coiled-coil-helix domain containing 10 | 1 | 1 | ||||||||
MIRT048970 | BSG | basigin (Ok blood group) | 1 | 1 | ||||||||
MIRT048971 | RABGAP1 | RAB GTPase activating protein 1 | 1 | 1 | ||||||||
MIRT048972 | NMD3 | NMD3 ribosome export adaptor | 1 | 1 | ||||||||
MIRT048973 | MRPL32 | mitochondrial ribosomal protein L32 | 1 | 1 | ||||||||
MIRT048974 | RPL11 | ribosomal protein L11 | 1 | 1 | ||||||||
MIRT048975 | WEE1 | WEE1 G2 checkpoint kinase | 1 | 1 | ||||||||
MIRT048976 | BAK1 | BCL2 antagonist/killer 1 | 2 | 3 | ||||||||
MIRT048977 | MYH2 | myosin heavy chain 2 | 1 | 1 | ||||||||
MIRT048978 | INSIG1 | insulin induced gene 1 | 2 | 4 | ||||||||
MIRT048979 | GARNL3 | GTPase activating Rap/RanGAP domain like 3 | 1 | 1 | ||||||||
MIRT048980 | HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 1 | 2 | ||||||||
MIRT048981 | TUBB2B | tubulin beta 2B class IIb | 1 | 1 | ||||||||
MIRT048982 | RPL24 | ribosomal protein L24 | 1 | 1 | ||||||||
MIRT048983 | HELQ | helicase, POLQ like | 1 | 1 | ||||||||
MIRT048984 | MAPK1IP1L | mitogen-activated protein kinase 1 interacting protein 1 like | 1 | 1 | ||||||||
MIRT048985 | PLA2G4F | phospholipase A2 group IVF | 1 | 1 | ||||||||
MIRT048986 | HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 1 | 1 | ||||||||
MIRT048987 | RASAL2 | RAS protein activator like 2 | 2 | 1 | ||||||||
MIRT048988 | RAD23B | RAD23 homolog B, nucleotide excision repair protein | 1 | 1 | ||||||||
MIRT048989 | PSMD11 | proteasome 26S subunit, non-ATPase 11 | 1 | 1 | ||||||||
MIRT048990 | TALDO1 | transaldolase 1 | 1 | 1 | ||||||||
MIRT048991 | CCDC6 | coiled-coil domain containing 6 | 1 | 1 | ||||||||
MIRT048992 | RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | 1 | 1 | ||||||||
MIRT048993 | CLNS1A | chloride nucleotide-sensitive channel 1A | 1 | 1 | ||||||||
MIRT048994 | NUCB1 | nucleobindin 1 | 1 | 1 | ||||||||
MIRT048995 | POTEG | POTE ankyrin domain family member G | 1 | 1 | ||||||||
MIRT048996 | DCAF12 | DDB1 and CUL4 associated factor 12 | 1 | 1 | ||||||||
MIRT048997 | USP9X | ubiquitin specific peptidase 9, X-linked | 1 | 1 | ||||||||
MIRT048998 | BLMH | bleomycin hydrolase | 1 | 1 | ||||||||
MIRT048999 | DCP2 | decapping mRNA 2 | 1 | 1 | ||||||||
MIRT049000 | SEC14L1 | SEC14 like lipid binding 1 | 1 | 1 | ||||||||
MIRT049001 | EIF3I | eukaryotic translation initiation factor 3 subunit I | 1 | 1 | ||||||||
MIRT049002 | NCL | nucleolin | 1 | 1 | ||||||||
MIRT049003 | MAP1B | microtubule associated protein 1B | 2 | 5 | ||||||||
MIRT049004 | GOLIM4 | golgi integral membrane protein 4 | 1 | 1 | ||||||||
MIRT049005 | EEF2 | eukaryotic translation elongation factor 2 | 1 | 1 | ||||||||
MIRT049006 | RASA1 | RAS p21 protein activator 1 | 1 | 1 | ||||||||
MIRT049007 | PLEKHB1 | pleckstrin homology domain containing B1 | 1 | 1 | ||||||||
MIRT049008 | CCNI | cyclin I | 1 | 1 | ||||||||
MIRT049009 | RPS25 | ribosomal protein S25 | 1 | 1 | ||||||||
MIRT049010 | FYCO1 | FYVE and coiled-coil domain containing 1 | 1 | 1 | ||||||||
MIRT049011 | AHCYL2 | adenosylhomocysteinase like 2 | 1 | 1 | ||||||||
MIRT049012 | ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 1 | 1 | ||||||||
MIRT049013 | GANAB | glucosidase II alpha subunit | 1 | 1 | ||||||||
MIRT049014 | CRBN | cereblon | 1 | 1 | ||||||||
MIRT049015 | MKI67 | marker of proliferation Ki-67 | 1 | 1 | ||||||||
MIRT049016 | LPIN1 | lipin 1 | 1 | 1 | ||||||||
MIRT049017 | KDM6B | lysine demethylase 6B | 1 | 1 | ||||||||
MIRT049018 | GPR89A | G protein-coupled receptor 89A | 1 | 1 | ||||||||
MIRT049019 | CBX6 | chromobox 6 | 1 | 1 | ||||||||
MIRT049020 | ANKLE2 | ankyrin repeat and LEM domain containing 2 | 1 | 1 | ||||||||
MIRT049021 | SCD5 | stearoyl-CoA desaturase 5 | 1 | 1 | ||||||||
MIRT049022 | NUDCD3 | NudC domain containing 3 | 1 | 1 | ||||||||
MIRT049023 | AGO1 | argonaute 1, RISC catalytic component | 1 | 1 | ||||||||
MIRT049024 | PKM | pyruvate kinase, muscle | 1 | 1 | ||||||||
MIRT049025 | NUP205 | nucleoporin 205 | 1 | 1 | ||||||||
MIRT049026 | RASA3 | RAS p21 protein activator 3 | 1 | 1 | ||||||||
MIRT049027 | EIF3C | eukaryotic translation initiation factor 3 subunit C | 1 | 1 | ||||||||
MIRT049028 | HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 1 | 1 | ||||||||
MIRT049029 | GHITM | growth hormone inducible transmembrane protein | 1 | 1 | ||||||||
MIRT049030 | PLEKHH3 | pleckstrin homology, MyTH4 and FERM domain containing H3 | 1 | 1 | ||||||||
MIRT049031 | RCAN1 | regulator of calcineurin 1 | 1 | 1 | ||||||||
MIRT049032 | UBE2H | ubiquitin conjugating enzyme E2 H | 1 | 1 | ||||||||
MIRT049033 | CCSAP | centriole, cilia and spindle associated protein | 1 | 1 | ||||||||
MIRT049034 | DHTKD1 | dehydrogenase E1 and transketolase domain containing 1 | 1 | 1 | ||||||||
MIRT049035 | IER3IP1 | immediate early response 3 interacting protein 1 | 1 | 1 | ||||||||
MIRT049036 | SLAIN1 | SLAIN motif family member 1 | 1 | 1 | ||||||||
MIRT049037 | NPLOC4 | NPL4 homolog, ubiquitin recognition factor | 1 | 1 | ||||||||
MIRT049038 | DOT1L | DOT1 like histone lysine methyltransferase | 1 | 1 | ||||||||
MIRT049039 | TPRN | taperin | 1 | 1 | ||||||||
MIRT049040 | RPL27 | ribosomal protein L27 | 1 | 1 | ||||||||
MIRT049041 | ELOVL6 | ELOVL fatty acid elongase 6 | 1 | 1 | ||||||||
MIRT049042 | DHRS3 | dehydrogenase/reductase 3 | 1 | 1 | ||||||||
MIRT049043 | FKBP1A | FK506 binding protein 1A | 2 | 5 | ||||||||
MIRT049044 | HIST1H3D | histone cluster 1 H3 family member d | 1 | 1 | ||||||||
MIRT049045 | ZNF785 | zinc finger protein 785 | 1 | 1 | ||||||||
MIRT049046 | ACAT2 | acetyl-CoA acetyltransferase 2 | 1 | 1 | ||||||||
MIRT049047 | ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif 1 | 1 | 1 | ||||||||
MIRT049048 | SPEN | spen family transcriptional repressor | 1 | 1 | ||||||||
MIRT049049 | TAOK2 | TAO kinase 2 | 1 | 1 | ||||||||
MIRT049050 | POLRMT | RNA polymerase mitochondrial | 1 | 1 | ||||||||
MIRT049051 | EFNA5 | ephrin A5 | 1 | 1 | ||||||||
MIRT049052 | SHC3 | SHC adaptor protein 3 | 1 | 1 | ||||||||
MIRT049053 | POLI | DNA polymerase iota | 1 | 1 | ||||||||
MIRT049054 | CDK11A | cyclin dependent kinase 11A | 1 | 1 | ||||||||
MIRT049055 | MAML1 | mastermind like transcriptional coactivator 1 | 1 | 1 | ||||||||
MIRT049056 | TUBB3 | tubulin beta 3 class III | 1 | 1 | ||||||||
MIRT049057 | CDK1 | cyclin dependent kinase 1 | 1 | 1 | ||||||||
MIRT049058 | KPNA6 | karyopherin subunit alpha 6 | 1 | 1 | ||||||||
MIRT049059 | FAF1 | Fas associated factor 1 | 1 | 1 | ||||||||
MIRT049060 | RPL7A | ribosomal protein L7a | 1 | 1 | ||||||||
MIRT049061 | EIF2B2 | eukaryotic translation initiation factor 2B subunit beta | 1 | 1 | ||||||||
MIRT049062 | DNM2 | dynamin 2 | 1 | 1 | ||||||||
MIRT049063 | ACADS | acyl-CoA dehydrogenase, C-2 to C-3 short chain | 1 | 1 | ||||||||
MIRT049064 | EIF3B | eukaryotic translation initiation factor 3 subunit B | 1 | 1 | ||||||||
MIRT049065 | CPSF6 | cleavage and polyadenylation specific factor 6 | 1 | 1 | ||||||||
MIRT049066 | PSMB1 | proteasome subunit beta 1 | 1 | 1 | ||||||||
MIRT049067 | PDE4DIP | phosphodiesterase 4D interacting protein | 1 | 1 | ||||||||
MIRT049068 | BTRC | beta-transducin repeat containing E3 ubiquitin protein ligase | 1 | 1 | ||||||||
MIRT049069 | TRIP12 | thyroid hormone receptor interactor 12 | 1 | 1 | ||||||||
MIRT049070 | TRAF4 | TNF receptor associated factor 4 | 1 | 1 | ||||||||
MIRT049071 | SLC25A38 | solute carrier family 25 member 38 | 1 | 1 | ||||||||
MIRT049072 | CEP85 | centrosomal protein 85 | 1 | 1 | ||||||||
MIRT049073 | CD59 | CD59 molecule (CD59 blood group) | 1 | 1 | ||||||||
MIRT049074 | RPA2 | replication protein A2 | 1 | 1 | ||||||||
MIRT049075 | B4GALT2 | beta-1,4-galactosyltransferase 2 | 1 | 1 | ||||||||
MIRT049076 | MLX | MLX, MAX dimerization protein | 1 | 1 | ||||||||
MIRT049077 | SELRC1 | cytochrome c oxidase assembly factor 7 (putative) | 1 | 1 | ||||||||
MIRT049078 | CXorf56 | chromosome X open reading frame 56 | 1 | 1 | ||||||||
MIRT049079 | KDM3B | lysine demethylase 3B | 1 | 1 | ||||||||
MIRT049080 | USP10 | ubiquitin specific peptidase 10 | 1 | 1 | ||||||||
MIRT049081 | TRMT61A | tRNA methyltransferase 61A | 1 | 1 | ||||||||
MIRT049082 | ENO1 | enolase 1 | 1 | 1 | ||||||||
MIRT049083 | PPP1R3G | protein phosphatase 1 regulatory subunit 3G | 1 | 1 | ||||||||
MIRT049084 | SNF8 | SNF8, ESCRT-II complex subunit | 1 | 1 | ||||||||
MIRT049085 | EBP | emopamil binding protein (sterol isomerase) | 1 | 1 | ||||||||
MIRT049086 | NTPCR | nucleoside-triphosphatase, cancer-related | 1 | 1 | ||||||||
MIRT049087 | LRRC37A2 | leucine rich repeat containing 37 member A2 | 1 | 1 | ||||||||
MIRT049088 | TNRC18 | trinucleotide repeat containing 18 | 1 | 1 | ||||||||
MIRT049089 | SRPRB | SRP receptor beta subunit | 1 | 1 | ||||||||
MIRT049090 | RCC1 | regulator of chromosome condensation 1 | 1 | 1 | ||||||||
MIRT049091 | PFDN6 | prefoldin subunit 6 | 1 | 1 | ||||||||
MIRT049092 | CMTM6 | CKLF like MARVEL transmembrane domain containing 6 | 1 | 1 | ||||||||
MIRT049093 | PBX2 | PBX homeobox 2 | 1 | 1 | ||||||||
MIRT049094 | MRPL9 | mitochondrial ribosomal protein L9 | 1 | 1 | ||||||||
MIRT049095 | KLHL15 | kelch like family member 15 | 2 | 8 | ||||||||
MIRT049096 | RPS15 | ribosomal protein S15 | 1 | 1 | ||||||||
MIRT049097 | SPTLC1 | serine palmitoyltransferase long chain base subunit 1 | 1 | 1 | ||||||||
MIRT049098 | HDAC1 | histone deacetylase 1 | 1 | 1 | ||||||||
MIRT049099 | MINK1 | misshapen like kinase 1 | 1 | 1 | ||||||||
MIRT049100 | HSP90B1 | heat shock protein 90 beta family member 1 | 1 | 1 | ||||||||
MIRT049101 | SKI | SKI proto-oncogene | 1 | 1 | ||||||||
MIRT049102 | NXN | nucleoredoxin | 1 | 1 | ||||||||
MIRT049103 | SACM1L | SAC1 like phosphatidylinositide phosphatase | 1 | 1 | ||||||||
MIRT049104 | TCOF1 | treacle ribosome biogenesis factor 1 | 1 | 1 | ||||||||
MIRT049105 | NFKB1 | nuclear factor kappa B subunit 1 | 1 | 1 | ||||||||
MIRT049106 | DDX17 | DEAD-box helicase 17 | 1 | 1 | ||||||||
MIRT049107 | PSMC3 | proteasome 26S subunit, ATPase 3 | 1 | 1 | ||||||||
MIRT049108 | HIP1R | huntingtin interacting protein 1 related | 1 | 1 | ||||||||
MIRT049109 | CCAR1 | cell division cycle and apoptosis regulator 1 | 1 | 1 | ||||||||
MIRT049110 | TUBA1C | tubulin alpha 1c | 1 | 1 | ||||||||
MIRT049111 | SNX9 | sorting nexin 9 | 1 | 1 | ||||||||
MIRT049112 | KPNA2 | karyopherin subunit alpha 2 | 1 | 1 | ||||||||
MIRT049113 | CSDE1 | cold shock domain containing E1 | 1 | 1 | ||||||||
MIRT049114 | YBX3 | Y-box binding protein 3 | 1 | 1 | ||||||||
MIRT049115 | CHAF1A | chromatin assembly factor 1 subunit A | 1 | 1 | ||||||||
MIRT049116 | APOLD1 | apolipoprotein L domain containing 1 | 1 | 1 | ||||||||
MIRT049117 | PDIK1L | PDLIM1 interacting kinase 1 like | 1 | 1 | ||||||||
MIRT049118 | C9orf64 | chromosome 9 open reading frame 64 | 1 | 1 | ||||||||
MIRT049119 | RANBP2 | RAN binding protein 2 | 1 | 1 | ||||||||
MIRT049120 | CDC25A | cell division cycle 25A | 1 | 1 | ||||||||
MIRT049121 | NACC2 | NACC family member 2 | 1 | 1 | ||||||||
MIRT049122 | TRIM28 | tripartite motif containing 28 | 1 | 1 | ||||||||
MIRT049123 | RPL3 | ribosomal protein L3 | 2 | 1 | ||||||||
MIRT049124 | CKB | creatine kinase B | 1 | 1 | ||||||||
MIRT049125 | SSX2IP | SSX family member 2 interacting protein | 1 | 1 | ||||||||
MIRT049126 | PDS5B | PDS5 cohesin associated factor B | 1 | 1 | ||||||||
MIRT049127 | WIPF2 | WAS/WASL interacting protein family member 2 | 1 | 1 | ||||||||
MIRT049128 | CC2D2A | coiled-coil and C2 domain containing 2A | 1 | 1 | ||||||||
MIRT049129 | DHCR24 | 24-dehydrocholesterol reductase | 1 | 1 | ||||||||
MIRT049130 | POR | cytochrome p450 oxidoreductase | 1 | 1 | ||||||||
MIRT049131 | EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 1 | 1 | ||||||||
MIRT049132 | TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 2 | 1 | ||||||||
MIRT049133 | AURKB | aurora kinase B | 1 | 1 | ||||||||
MIRT049134 | AIDA | axin interactor, dorsalization associated | 1 | 1 | ||||||||
MIRT049135 | DNAJA3 | DnaJ heat shock protein family (Hsp40) member A3 | 1 | 1 | ||||||||
MIRT049136 | PXN | paxillin | 1 | 1 | ||||||||
MIRT049137 | PARK7 | Parkinsonism associated deglycase | 1 | 1 | ||||||||
MIRT049138 | HDGF | heparin binding growth factor | 1 | 1 | ||||||||
MIRT049139 | LIMD1 | LIM domains containing 1 | 1 | 1 | ||||||||
MIRT049140 | PTGFRN | prostaglandin F2 receptor inhibitor | 1 | 1 | ||||||||
MIRT049141 | COX18 | COX18, cytochrome c oxidase assembly factor | 1 | 1 | ||||||||
MIRT049142 | MYO19 | myosin XIX | 1 | 1 | ||||||||
MIRT049143 | ZNF276 | zinc finger protein 276 | 1 | 1 | ||||||||
MIRT049144 | AARS2 | alanyl-tRNA synthetase 2, mitochondrial | 1 | 1 | ||||||||
MIRT049145 | ETFA | electron transfer flavoprotein alpha subunit | 1 | 1 | ||||||||
MIRT049146 | SART3 | squamous cell carcinoma antigen recognized by T-cells 3 | 1 | 1 | ||||||||
MIRT049147 | TEX10 | testis expressed 10 | 1 | 1 | ||||||||
MIRT049148 | PFN1 | profilin 1 | 1 | 1 | ||||||||
MIRT049149 | EPHA7 | EPH receptor A7 | 1 | 1 | ||||||||
MIRT049150 | WDR6 | WD repeat domain 6 | 1 | 1 | ||||||||
MIRT049151 | UBAP2L | ubiquitin associated protein 2 like | 1 | 1 | ||||||||
MIRT049152 | TESK1 | testis-specific kinase 1 | 1 | 2 | ||||||||
MIRT049153 | ZNF503 | zinc finger protein 503 | 1 | 1 | ||||||||
MIRT049154 | DENND5A | DENN domain containing 5A | 1 | 1 | ||||||||
MIRT049155 | PRR12 | proline rich 12 | 1 | 1 | ||||||||
MIRT049156 | BTAF1 | B-TFIID TATA-box binding protein associated factor 1 | 1 | 1 | ||||||||
MIRT049157 | MYO5C | myosin VC | 1 | 1 | ||||||||
MIRT049158 | MRPL3 | mitochondrial ribosomal protein L3 | 1 | 1 | ||||||||
MIRT049159 | CDKN3 | cyclin dependent kinase inhibitor 3 | 1 | 1 | ||||||||
MIRT049160 | RBBP7 | RB binding protein 7, chromatin remodeling factor | 1 | 1 | ||||||||
MIRT049161 | PHACTR4 | phosphatase and actin regulator 4 | 1 | 1 | ||||||||
MIRT049162 | NPM1 | nucleophosmin 1 | 1 | 1 | ||||||||
MIRT049163 | KMT2D | lysine methyltransferase 2D | 1 | 1 | ||||||||
MIRT049164 | PKN1 | protein kinase N1 | 1 | 1 | ||||||||
MIRT049165 | MDN1 | midasin AAA ATPase 1 | 1 | 1 | ||||||||
MIRT049166 | RPL18A | ribosomal protein L18a | 1 | 1 | ||||||||
MIRT049167 | ISM2 | isthmin 2 | 1 | 1 | ||||||||
MIRT049168 | QSOX2 | quiescin sulfhydryl oxidase 2 | 1 | 1 | ||||||||
MIRT049169 | SHMT2 | serine hydroxymethyltransferase 2 | 1 | 1 | ||||||||
MIRT049170 | RIOK1 | RIO kinase 1 | 1 | 1 | ||||||||
MIRT049171 | ARID1A | AT-rich interaction domain 1A | 1 | 1 | ||||||||
MIRT049172 | IGSF1 | immunoglobulin superfamily member 1 | 1 | 1 | ||||||||
MIRT049173 | PPIB | peptidylprolyl isomerase B | 1 | 1 | ||||||||
MIRT049174 | PPP1CC | protein phosphatase 1 catalytic subunit gamma | 1 | 1 | ||||||||
MIRT049175 | CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | 1 | 1 | ||||||||
MIRT049176 | NFIB | nuclear factor I B | 1 | 1 | ||||||||
MIRT049177 | STARD7 | StAR related lipid transfer domain containing 7 | 1 | 1 | ||||||||
MIRT049178 | DYNC1H1 | dynein cytoplasmic 1 heavy chain 1 | 1 | 1 | ||||||||
MIRT049179 | FNDC3B | fibronectin type III domain containing 3B | 1 | 2 | ||||||||
MIRT049180 | SRSF5 | serine and arginine rich splicing factor 5 | 1 | 1 | ||||||||
MIRT049181 | KIFC1 | kinesin family member C1 | 1 | 1 | ||||||||
MIRT049182 | EARS2 | glutamyl-tRNA synthetase 2, mitochondrial | 1 | 2 | ||||||||
MIRT049183 | MCM3 | minichromosome maintenance complex component 3 | 1 | 1 | ||||||||
MIRT049184 | TUSC2 | tumor suppressor candidate 2 | 1 | 1 | ||||||||
MIRT049185 | CLDND1 | claudin domain containing 1 | 1 | 1 | ||||||||
MIRT049186 | BRCC3 | BRCA1/BRCA2-containing complex subunit 3 | 1 | 1 | ||||||||
MIRT049187 | ACTR1A | ARP1 actin related protein 1 homolog A | 1 | 1 | ||||||||
MIRT049188 | DHX16 | DEAH-box helicase 16 | 1 | 1 | ||||||||
MIRT049189 | KIAA0100 | KIAA0100 | 1 | 1 | ||||||||
MIRT049190 | DUSP11 | dual specificity phosphatase 11 | 1 | 1 | ||||||||
MIRT049191 | ARRB1 | arrestin beta 1 | 1 | 1 | ||||||||
MIRT049192 | ATP1A1 | ATPase Na+/K+ transporting subunit alpha 1 | 1 | 1 | ||||||||
MIRT049193 | VARS | valyl-tRNA synthetase | 1 | 1 | ||||||||
MIRT049194 | ITPR3 | inositol 1,4,5-trisphosphate receptor type 3 | 1 | 1 | ||||||||
MIRT049195 | AXIN1 | axin 1 | 1 | 1 | ||||||||
MIRT049196 | RPL13A | ribosomal protein L13a | 1 | 1 | ||||||||
MIRT049197 | STX3 | syntaxin 3 | 1 | 1 | ||||||||
MIRT049198 | GLOD4 | glyoxalase domain containing 4 | 1 | 1 | ||||||||
MIRT049199 | U2AF2 | U2 small nuclear RNA auxiliary factor 2 | 1 | 1 | ||||||||
MIRT049200 | KCTD5 | potassium channel tetramerization domain containing 5 | 1 | 1 | ||||||||
MIRT049201 | GSTP1 | glutathione S-transferase pi 1 | 1 | 1 | ||||||||
MIRT049202 | GOT2 | glutamic-oxaloacetic transaminase 2 | 1 | 1 | ||||||||
MIRT049203 | COL18A1 | collagen type XVIII alpha 1 chain | 1 | 1 | ||||||||
MIRT049204 | NOC2L | NOC2 like nucleolar associated transcriptional repressor | 1 | 1 | ||||||||
MIRT049205 | USP31 | ubiquitin specific peptidase 31 | 1 | 1 | ||||||||
MIRT049206 | RBX1 | ring-box 1 | 1 | 1 | ||||||||
MIRT049207 | SCML2 | Scm polycomb group protein like 2 | 1 | 1 | ||||||||
MIRT049208 | ARPP19 | cAMP regulated phosphoprotein 19 | 1 | 1 | ||||||||
MIRT049209 | CCDC86 | coiled-coil domain containing 86 | 1 | 1 | ||||||||
MIRT049210 | P4HB | prolyl 4-hydroxylase subunit beta | 1 | 1 | ||||||||
MIRT049211 | LMBR1L | limb development membrane protein 1 like | 1 | 1 | ||||||||
MIRT049212 | CDK9 | cyclin dependent kinase 9 | 1 | 1 | ||||||||
MIRT049213 | BCL9L | B-cell CLL/lymphoma 9 like | 1 | 1 | ||||||||
MIRT049214 | TUFM | Tu translation elongation factor, mitochondrial | 1 | 1 | ||||||||
MIRT049215 | RPL15 | ribosomal protein L15 | 1 | 1 | ||||||||
MIRT049216 | ALMS1 | ALMS1, centrosome and basal body associated protein | 1 | 1 | ||||||||
MIRT049217 | MLLT4 | afadin, adherens junction formation factor | 1 | 1 | ||||||||
MIRT049218 | CUL5 | cullin 5 | 1 | 1 | ||||||||
MIRT049219 | KPNB1 | karyopherin subunit beta 1 | 1 | 1 | ||||||||
MIRT049220 | MYO1C | myosin IC | 1 | 1 | ||||||||
MIRT049221 | TLR10 | toll like receptor 10 | 1 | 1 | ||||||||
MIRT049222 | COX4I1 | cytochrome c oxidase subunit 4I1 | 1 | 1 | ||||||||
MIRT049223 | SF3B3 | splicing factor 3b subunit 3 | 1 | 1 | ||||||||
MIRT049224 | CTNNBL1 | catenin beta like 1 | 1 | 1 | ||||||||
MIRT049225 | YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta | 1 | 1 | ||||||||
MIRT049226 | BRD2 | bromodomain containing 2 | 1 | 1 | ||||||||
MIRT049227 | PFKM | phosphofructokinase, muscle | 1 | 1 | ||||||||
MIRT049228 | PPP6C | protein phosphatase 6 catalytic subunit | 1 | 1 | ||||||||
MIRT049229 | NFE2L1 | nuclear factor, erythroid 2 like 1 | 1 | 1 | ||||||||
MIRT049230 | SHOC2 | SHOC2, leucine rich repeat scaffold protein | 1 | 1 | ||||||||
MIRT049231 | KIAA1671 | KIAA1671 | 1 | 1 | ||||||||
MIRT049232 | HIST1H1E | histone cluster 1 H1 family member e | 1 | 1 | ||||||||
MIRT049233 | R3HDM4 | R3H domain containing 4 | 1 | 1 | ||||||||
MIRT049234 | SURF4 | surfeit 4 | 1 | 1 | ||||||||
MIRT049235 | METTL16 | methyltransferase like 16 | 1 | 1 | ||||||||
MIRT049236 | ZNF420 | zinc finger protein 420 | 1 | 1 | ||||||||
MIRT049237 | ARPC2 | actin related protein 2/3 complex subunit 2 | 1 | 1 | ||||||||
MIRT049238 | RRP9 | ribosomal RNA processing 9, U3 small nucleolar RNA binding protein | 1 | 1 | ||||||||
MIRT049239 | HEATR1 | HEAT repeat containing 1 | 1 | 1 | ||||||||
MIRT049240 | HSPA1B | heat shock protein family A (Hsp70) member 1B | 1 | 1 | ||||||||
MIRT049241 | PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 1 | 1 | ||||||||
MIRT049242 | MACF1 | microtubule-actin crosslinking factor 1 | 1 | 1 | ||||||||
MIRT049243 | HNRNPF | heterogeneous nuclear ribonucleoprotein F | 1 | 1 | ||||||||
MIRT049244 | VCPIP1 | valosin containing protein interacting protein 1 | 1 | 1 | ||||||||
MIRT049245 | CORO7 | coronin 7 | 1 | 1 | ||||||||
MIRT049246 | UNC13B | unc-13 homolog B | 1 | 1 | ||||||||
MIRT049247 | PSMD3 | proteasome 26S subunit, non-ATPase 3 | 1 | 1 | ||||||||
MIRT049248 | DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 1 | 1 | ||||||||
MIRT049249 | MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 2 | 3 | ||||||||
MIRT049250 | HS3ST3A1 | heparan sulfate-glucosamine 3-sulfotransferase 3A1 | 1 | 1 | ||||||||
MIRT049251 | ALKBH5 | alkB homolog 5, RNA demethylase | 1 | 1 | ||||||||
MIRT049252 | TKT | transketolase | 1 | 1 | ||||||||
MIRT049253 | DLX6 | distal-less homeobox 6 | 1 | 1 | ||||||||
MIRT049254 | OSBPL2 | oxysterol binding protein like 2 | 2 | 1 | ||||||||
MIRT049255 | CDC37 | cell division cycle 37 | 1 | 1 | ||||||||
MIRT049256 | CLTC | clathrin heavy chain | 1 | 1 | ||||||||
MIRT049257 | TUT1 | terminal uridylyl transferase 1, U6 snRNA-specific | 1 | 1 | ||||||||
MIRT049258 | GLO1 | glyoxalase I | 1 | 1 | ||||||||
MIRT049259 | ZC3H18 | zinc finger CCCH-type containing 18 | 1 | 1 | ||||||||
MIRT049260 | HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 | 1 | 1 | ||||||||
MIRT049261 | EIF3K | eukaryotic translation initiation factor 3 subunit K | 1 | 1 | ||||||||
MIRT049262 | DCTD | dCMP deaminase | 1 | 1 | ||||||||
MIRT049263 | MYL6 | myosin light chain 6 | 1 | 1 | ||||||||
MIRT049264 | FAM135A | family with sequence similarity 135 member A | 1 | 2 | ||||||||
MIRT049265 | ZNF507 | zinc finger protein 507 | 1 | 1 | ||||||||
MIRT049266 | EDC4 | enhancer of mRNA decapping 4 | 1 | 1 | ||||||||
MIRT049267 | SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 1 | 1 | ||||||||
MIRT049268 | PFDN2 | prefoldin subunit 2 | 1 | 1 | ||||||||
MIRT049269 | ZFHX4 | zinc finger homeobox 4 | 1 | 1 | ||||||||
MIRT049270 | HOGA1 | 4-hydroxy-2-oxoglutarate aldolase 1 | 1 | 1 | ||||||||
MIRT049271 | IL17RA | interleukin 17 receptor A | 1 | 1 | ||||||||
MIRT049272 | LXN | latexin | 1 | 1 | ||||||||
MIRT049273 | PDCD6IP | programmed cell death 6 interacting protein | 1 | 1 | ||||||||
MIRT049274 | CD2AP | CD2 associated protein | 1 | 2 | ||||||||
MIRT049275 | RPS14 | ribosomal protein S14 | 1 | 1 | ||||||||
MIRT049276 | ABCA3 | ATP binding cassette subfamily A member 3 | 1 | 1 | ||||||||
MIRT049277 | HOXA5 | homeobox A5 | 1 | 1 | ||||||||
MIRT049278 | FBXO45 | F-box protein 45 | 1 | 1 | ||||||||
MIRT049279 | ILF2 | interleukin enhancer binding factor 2 | 1 | 1 | ||||||||
MIRT049280 | HIST1H4C | histone cluster 1 H4 family member c | 1 | 1 | ||||||||
MIRT049281 | KIF1A | kinesin family member 1A | 1 | 1 | ||||||||
MIRT049282 | HSPA8 | heat shock protein family A (Hsp70) member 8 | 1 | 1 | ||||||||
MIRT049283 | BAG6 | BCL2 associated athanogene 6 | 1 | 1 | ||||||||
MIRT049284 | SYNPR | synaptoporin | 1 | 1 | ||||||||
MIRT049285 | PPIL1 | peptidylprolyl isomerase like 1 | 1 | 1 | ||||||||
MIRT049286 | PYGL | glycogen phosphorylase L | 1 | 1 | ||||||||
MIRT049287 | NAA25 | N(alpha)-acetyltransferase 25, NatB auxiliary subunit | 1 | 1 | ||||||||
MIRT049288 | HSP90AB1 | heat shock protein 90 alpha family class B member 1 | 1 | 1 | ||||||||
MIRT049289 | DIDO1 | death inducer-obliterator 1 | 1 | 1 | ||||||||
MIRT049290 | LARP1 | La ribonucleoprotein domain family member 1 | 1 | 1 | ||||||||
MIRT049291 | PHF12 | PHD finger protein 12 | 1 | 1 | ||||||||
MIRT049292 | ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | 1 | 1 | ||||||||
MIRT049293 | CBS | cystathionine-beta-synthase | 1 | 1 | ||||||||
MIRT049294 | DDX5 | DEAD-box helicase 5 | 1 | 1 | ||||||||
MIRT049295 | SERINC1 | serine incorporator 1 | 1 | 1 | ||||||||
MIRT049296 | GNG7 | G protein subunit gamma 7 | 1 | 1 | ||||||||
MIRT049297 | C11orf57 | chromosome 11 open reading frame 57 | 1 | 1 | ||||||||
MIRT049298 | ERAP1 | endoplasmic reticulum aminopeptidase 1 | 1 | 1 | ||||||||
MIRT049299 | TMEM55B | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 | 1 | 1 | ||||||||
MIRT049300 | HIST1H2AB | histone cluster 1 H2A family member b | 1 | 1 | ||||||||
MIRT049301 | TNPO1 | transportin 1 | 1 | 2 | ||||||||
MIRT049302 | COL4A2 | collagen type IV alpha 2 chain | 1 | 1 | ||||||||
MIRT049303 | CBX2 | chromobox 2 | 1 | 1 | ||||||||
MIRT049304 | EPHA4 | EPH receptor A4 | 1 | 1 | ||||||||
MIRT049305 | COPG1 | coatomer protein complex subunit gamma 1 | 1 | 1 | ||||||||
MIRT049306 | DHX8 | DEAH-box helicase 8 | 1 | 1 | ||||||||
MIRT049307 | TUBB4B | tubulin beta 4B class IVb | 1 | 1 | ||||||||
MIRT049308 | TMEM161A | transmembrane protein 161A | 1 | 1 | ||||||||
MIRT049309 | KHSRP | KH-type splicing regulatory protein | 1 | 1 | ||||||||
MIRT049310 | GOLGA3 | golgin A3 | 2 | 6 | ||||||||
MIRT049311 | ZNF622 | zinc finger protein 622 | 1 | 1 | ||||||||
MIRT049312 | FAM168B | family with sequence similarity 168 member B | 1 | 1 | ||||||||
MIRT049313 | KANK2 | KN motif and ankyrin repeat domains 2 | 1 | 1 | ||||||||
MIRT049314 | SIN3A | SIN3 transcription regulator family member A | 1 | 1 | ||||||||
MIRT049315 | MDM2 | MDM2 proto-oncogene | 2 | 3 | ||||||||
MIRT049316 | MAP4 | microtubule associated protein 4 | 1 | 1 | ||||||||
MIRT049317 | MAVS | mitochondrial antiviral signaling protein | 1 | 1 | ||||||||
MIRT049318 | CBFB | core-binding factor beta subunit | 1 | 1 | ||||||||
MIRT049319 | CTLA4 | cytotoxic T-lymphocyte associated protein 4 | 1 | 1 | ||||||||
MIRT049320 | PCNXL4 | pecanex homolog 4 | 1 | 1 | ||||||||
MIRT049321 | SIN3B | SIN3 transcription regulator family member B | 1 | 1 | ||||||||
MIRT049322 | NPC2 | NPC intracellular cholesterol transporter 2 | 1 | 1 | ||||||||
MIRT049323 | POLR2I | RNA polymerase II subunit I | 1 | 1 | ||||||||
MIRT049324 | HIST1H2AM | histone cluster 1 H2A family member m | 1 | 1 | ||||||||
MIRT049325 | RNF123 | ring finger protein 123 | 1 | 1 | ||||||||
MIRT049326 | WDR18 | WD repeat domain 18 | 1 | 1 | ||||||||
MIRT049327 | RPS28 | ribosomal protein S28 | 1 | 1 | ||||||||
MIRT049328 | FAM129B | family with sequence similarity 129 member B | 1 | 1 | ||||||||
MIRT049329 | ZCCHC2 | zinc finger CCHC-type containing 2 | 1 | 1 | ||||||||
MIRT049330 | EPB41L3 | erythrocyte membrane protein band 4.1 like 3 | 1 | 1 | ||||||||
MIRT049331 | MAPRE1 | microtubule associated protein RP/EB family member 1 | 3 | 1 | ||||||||
MIRT049332 | NT5DC3 | 5'-nucleotidase domain containing 3 | 1 | 1 | ||||||||
MIRT049333 | AHCYL1 | adenosylhomocysteinase like 1 | 1 | 1 | ||||||||
MIRT049334 | KLC2 | kinesin light chain 2 | 1 | 1 | ||||||||
MIRT049335 | ZBTB22 | zinc finger and BTB domain containing 22 | 1 | 1 | ||||||||
MIRT049336 | TSR1 | TSR1, ribosome maturation factor | 1 | 1 | ||||||||
MIRT049337 | NUP155 | nucleoporin 155 | 1 | 1 | ||||||||
MIRT049338 | HIST2H2AA3 | histone cluster 2 H2A family member a3 | 1 | 1 | ||||||||
MIRT049339 | DDX39A | DExD-box helicase 39A | 1 | 1 | ||||||||
MIRT049340 | CAMTA2 | calmodulin binding transcription activator 2 | 1 | 1 | ||||||||
MIRT049341 | RNF40 | ring finger protein 40 | 1 | 1 | ||||||||
MIRT049342 | NCAPH | non-SMC condensin I complex subunit H | 1 | 1 | ||||||||
MIRT049343 | MYO1D | myosin ID | 1 | 2 | ||||||||
MIRT049344 | APOBEC3C | apolipoprotein B mRNA editing enzyme catalytic subunit 3C | 1 | 1 | ||||||||
MIRT049345 | GSK3B | glycogen synthase kinase 3 beta | 1 | 1 | ||||||||
MIRT049346 | SARS2 | seryl-tRNA synthetase 2, mitochondrial | 1 | 1 | ||||||||
MIRT049347 | C17orf51 | chromosome 17 open reading frame 51 | 1 | 1 | ||||||||
MIRT049348 | RAB11A | RAB11A, member RAS oncogene family | 1 | 1 | ||||||||
MIRT049349 | EIF4B | eukaryotic translation initiation factor 4B | 1 | 1 | ||||||||
MIRT049350 | OTUD6A | OTU deubiquitinase 6A | 1 | 1 | ||||||||
MIRT049351 | CERS1 | ceramide synthase 1 | 1 | 1 | ||||||||
MIRT049352 | ENOPH1 | enolase-phosphatase 1 | 1 | 1 | ||||||||
MIRT049353 | CAD | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | 1 | 1 | ||||||||
MIRT049354 | KIAA1549 | KIAA1549 | 1 | 1 | ||||||||
MIRT049355 | CELSR1 | cadherin EGF LAG seven-pass G-type receptor 1 | 1 | 1 | ||||||||
MIRT049356 | PSMB6 | proteasome subunit beta 6 | 1 | 1 | ||||||||
MIRT049357 | IRAK1 | interleukin 1 receptor associated kinase 1 | 1 | 1 | ||||||||
MIRT049358 | ORC5 | origin recognition complex subunit 5 | 1 | 1 | ||||||||
MIRT049359 | STAT3 | signal transducer and activator of transcription 3 | 4 | 2 | ||||||||
MIRT049360 | PKDCC | protein kinase domain containing, cytoplasmic | 1 | 1 | ||||||||
MIRT049361 | HNRNPM | heterogeneous nuclear ribonucleoprotein M | 1 | 1 | ||||||||
MIRT049362 | AP2B1 | adaptor related protein complex 2 beta 1 subunit | 1 | 1 | ||||||||
MIRT049363 | FASN | fatty acid synthase | 1 | 1 | ||||||||
MIRT049364 | SMC3 | structural maintenance of chromosomes 3 | 1 | 1 | ||||||||
MIRT049365 | RNF2 | ring finger protein 2 | 1 | 1 | ||||||||
MIRT049366 | ZNF84 | zinc finger protein 84 | 1 | 1 | ||||||||
MIRT049367 | CCNE1 | cyclin E1 | 1 | 1 | ||||||||
MIRT049368 | RTCB | RNA 2',3'-cyclic phosphate and 5'-OH ligase | 1 | 1 | ||||||||
MIRT049369 | TBL1X | transducin beta like 1X-linked | 1 | 1 | ||||||||
MIRT049370 | ATP5B | ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide | 1 | 1 | ||||||||
MIRT049371 | TGFBRAP1 | transforming growth factor beta receptor associated protein 1 | 1 | 1 | ||||||||
MIRT049372 | TRAP1 | TNF receptor associated protein 1 | 2 | 1 | ||||||||
MIRT049373 | ACLY | ATP citrate lyase | 1 | 1 | ||||||||
MIRT049374 | GTF3C1 | general transcription factor IIIC subunit 1 | 1 | 1 | ||||||||
MIRT049375 | SLC25A44 | solute carrier family 25 member 44 | 1 | 1 | ||||||||
MIRT049376 | SMAP2 | small ArfGAP2 | 1 | 1 | ||||||||
MIRT049377 | DDX56 | DEAD-box helicase 56 | 1 | 1 | ||||||||
MIRT049378 | TWISTNB | TWIST neighbor | 1 | 1 | ||||||||
MIRT049379 | CCDC57 | coiled-coil domain containing 57 | 1 | 1 | ||||||||