miRTarBase - #MIRT006329


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pre-miRNA Information
pre-miRNA hsa-mir-137   
Genomic Coordinates chr1: 98046070 - 98046171
Description Homo sapiens miR-137 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-137
Sequence 59| UUAUUGCUUAAGAAUACGCGUAG |81
Evidence Experimental
Experiments Cloned
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B41RDC miR-137 Safety Biomarker (SAF) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol PTGS2   
Synonyms COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2
Description prostaglandin-endoperoxide synthase 2
Transcript NM_000963   
Expression
Putative miRNA Targets on PTGS2
3'UTR of PTGS2
(miRNA target sites are highlighted)		 
>PTGS2|NM_000963|3'UTR
   1 AAGTCTAATGATCATATTTATTTATTTATATGAACCATGTCTATTAATTTAATTATTTAATAATATTTATATTAAACTCC
  81 TTATGTTACTTAACATCTTCTGTAACAGAAGTCAGTACTCCTGTTGCGGAGAAAGGAGTCATACTTGTGAAGACTTTTAT
 161 GTCACTACTCTAAAGATTTTGCTGTTGCTGTTAAGTTTGGAAAACAGTTTTTATTCTGTTTTATAAACCAGAGAGAAATG
 241 AGTTTTGACGTCTTTTTACTTGAATTTCAACTTATATTATAAGAACGAAAGTAAAGATGTTTGAATACTTAAACACTGTC
 321 ACAAGATGGCAAAATGCTGAAAGTTTTTACACTGTCGATGTTTCCAATGCATCTTCCATGATGCATTAGAAGTAACTAAT
 401 GTTTGAAATTTTAAAGTACTTTTGGTTATTTTTCTGTCATCAAACAAAAACAGGTATCAGTGCATTATTAAATGAATATT
 481 TAAATTAGACATTACCAGTAATTTCATGTCTACTTTTTAAAATCAGCAATGAAACAATAATTTGAAATTTCTAAATTCAT
 561 AGGGTAGAATCACCTGTAAAAGCTTGTTTGATTTCTTAAAGTTATTAAACTTGTACATATACCAAAAAGAAGCTGTCTTG
 641 GATTTAAATCTGTAAAATCAGTAGAAATTTTACTACAATTGCTTGTTAAAATATTTTATAAGTGATGTTCCTTTTTCACC
 721 AAGAGTATAAACCTTTTTAGTGTGACTGTTAAAACTTCCTTTTAAATCAAAATGCCAAATTTATTAAGGTGGTGGAGCCA
 801 CTGCAGTGTTATCTTAAAATAAGAATATTTTGTTGAGATATTCCAGAATTTGTTTATATGGCTGGTAACATGTAAAATCT
 881 ATATCAGCAAAAGGGTCTACCTTTAAAATAAGCAATAACAAAGAAGAAAACCAAATTATTGTTCAAATTTAGGTTTAAAC
 961 TTTTGAAGCAAACTTTTTTTTATCCTTGTGCACTGCAGGCCTGGTACTCAGATTTTGCTATGAGGTTAATGAAGTACCAA
1041 GCTGTGCTTGAATAATGATATGTTTTCTCAGATTTTCTGTTGTACAGTTTAATTTAGCAGTCCATATCACATTGCAAAAG
1121 TAGCAATGACCTCATAAAATACCTCTTCAAAATGCTTAAATTCATTTCACACATTAATTTTATCTCAGTCTTGAAGCCAA
1201 TTCAGTAGGTGCATTGGAATCAAGCCTGGCTACCTGCATGCTGTTCCTTTTCTTTTCTTCTTTTAGCCATTTTGCTAAGA
1281 GACACAGTCTTCTCATCACTTCGTTTCTCCTATTTTGTTTTACTAGTTTTAAGATCAGAGTTCACTTTCTTTGGACTCTG
1361 CCTATATTTTCTTACCTGAACTTTTGCAAGTTTTCAGGTAAACCTCAGCTCAGGACTGCTATTTAGCTCCTCTTAAGAAG
1441 ATTAAAAGAGAAAAAAAAAGGCCCTTTTAAAAATAGTATACACTTATTTTAAGTGAAAAGCAGAGAATTTTATTTATAGC
1521 TAATTTTAGCTATCTGTAACCAAGATGGATGCAAAGAGGCTAGTGCCTCAGAGAGAACTGTACGGGGTTTGTGACTGGAA
1601 AAAGTTACGTTCCCATTCTAATTAATGCCCTTTCTTATTTAAAAACAAAACCAAATGATATCTAAGTAGTTCTCAGCAAT
1681 AATAATAATGACGATAATACTTCTTTTCCACATCTCATTGTCACTGACATTTAATGGTACTGTATATTACTTAATTTATT
1761 GAAGATTATTATTTATGTCTTATTAGGACACTATGGTTATAAACTGTGTTTAAGCCTACAATCATTGATTTTTTTTTGTT
1841 ATGTCACAATCAGTATATTTTCTTTGGGGTTACCTCTCTGAATATTATGTAAACAATCCAAAGAAATGATTGTATTAAGA
1921 TTTGTGAATAAATTTTTAGAAATCTGATTGGCATATTGAGATATTTAAGGTTGAATGTTTGTCCTTAGGATAGGCCTATG
2001 TGCTAGCCCACAAAGAATATTGTCTCATTAGCCTGAATGTGCCATAAGACTGACCTTTTAAAATGTTTTGAGGGATCTGT
2081 GGATGCTTCGTTAATTTGTTCAGCCACAATTTATTGAGAAAATATTCTGTGTCAAGCACTGTGGGTTTTAATATTTTTAA
2161 ATCAAACGCTGATTACAGATAATAGTATTTATATAAATAATTGAAAAAAATTTTCTTTTGGGAAGAGGGAGAAAATGAAA
2241 TAAATATCATTAAAGATAACTCAGGAGAATCTTCTTTACAATTTTACGTTTAGAATGTTTAAGGTTAAGAAAGAAATAGT
2321 CAATATGCTTGTATAAAACACTGTTCACTGTTTTTTTTAAAAAAAAAACTTGATTTGTTATTAACATTGATCTGCTGACA
2401 AAACCTGGGAATTTGGGTTGTGTATGCGAATGTTTCAGTGCCTCAGACAAATGTGTATTTAACTTATGTAAAAGATAAGT
2481 CTGGAAATAAATGTCTGTTTATTTTTGTACTATTTAAAAATTGACAGATCTTTTCTGAAGAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaugcgCAUAAGAAUUCGUUAUu 5'
                ||| |: | ||||||| 
Target 5' atctaaGTAGTTCTCAGCAATAa 3'
 1660 - 1682 157.00 -11.90
2 
miRNA  3' gaUGCGCAUA---AGA----AUUCGUUAUu 5'
            | | || |   |:|    ||||||||| 
Target 5' aaAAGGGTCTACCTTTAAAATAAGCAATAa 3'
 889 - 918 151.00 -12.40
3 
miRNA  3' gaUGCGCAU-AAGAAU-----UCGUUAUu 5'
            |:|: || ||:|||     ||||||: 
Target 5' tcATGTCTACTTTTTAAAATCAGCAATGa 3'
 504 - 532 145.00 -8.75
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN32063368 11 COSMIC
COSN13501525 41 COSMIC
COSN30171731 59 COSMIC
COSN6012382 86 COSMIC
COSN31596289 88 COSMIC
COSN28193603 104 COSMIC
COSN31607826 108 COSMIC
COSN31588012 128 COSMIC
COSN31597617 154 COSMIC
COSN26636352 163 COSMIC
COSN26507827 175 COSMIC
COSN1417918 200 COSMIC
COSN31960366 212 COSMIC
COSN31608962 287 COSMIC
COSN21476079 294 COSMIC
COSN31547595 296 COSMIC
COSN25477166 303 COSMIC
COSN6012381 344 COSMIC
COSN25091087 428 COSMIC
COSN32055691 629 COSMIC
COSN21253320 768 COSMIC
COSN28201691 1042 COSMIC
COSN16743414 1229 COSMIC
COSN149770 1442 COSMIC
COSN31570362 1602 COSMIC
COSN18872140 1618 COSMIC
COSN26556474 1646 COSMIC
COSN31512787 1670 COSMIC
COSN30020284 1692 COSMIC
COSN28732736 1742 COSMIC
COSN31515470 1764 COSMIC
COSN31573031 1791 COSMIC
COSN31536096 1827 COSMIC
COSN31562072 1874 COSMIC
COSN6012380 1929 COSMIC
COSN23236177 1934 COSMIC
COSN24423038 2167 COSMIC
COSN14468694 2211 COSMIC
COSN25681305 2231 COSMIC
COSN20095686 2358 COSMIC
COSN7467062 2359 COSMIC
COSN27459857 2367 COSMIC
COSN25915890 2453 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs561157840 3 dbSNP
rs773979740 4 dbSNP
rs1283691765 7 dbSNP
rs1234044103 8 dbSNP
rs768056746 9 dbSNP
rs762892168 15 dbSNP
rs775591657 19 dbSNP
rs926587956 25 dbSNP
rs769676428 27 dbSNP
rs745701374 28 dbSNP
rs778122608 29 dbSNP
rs1432745292 30 dbSNP
rs199738725 30 dbSNP
rs772483298 33 dbSNP
rs766788918 36 dbSNP
rs1173970237 38 dbSNP
rs748169012 41 dbSNP
rs778980844 49 dbSNP
rs201534244 57 dbSNP
rs1370491544 60 dbSNP
rs982117310 60 dbSNP
rs1378058908 72 dbSNP
rs759062921 77 dbSNP
rs1229736270 81 dbSNP
rs200232733 85 dbSNP
rs1288880836 94 dbSNP
rs542780589 96 dbSNP
rs970929062 103 dbSNP
rs202188713 107 dbSNP
rs1211582207 108 dbSNP
rs1291674493 117 dbSNP
rs4648289 121 dbSNP
rs200536698 127 dbSNP
rs201923275 128 dbSNP
rs1183061939 135 dbSNP
rs1417769951 142 dbSNP
rs982939397 143 dbSNP
rs1165526126 158 dbSNP
rs1294198111 170 dbSNP
rs1391850757 171 dbSNP
rs1024796780 172 dbSNP
rs1409786914 181 dbSNP
rs1327725609 184 dbSNP
rs200786963 184 dbSNP
rs1352447586 186 dbSNP
rs953020594 190 dbSNP
rs1012771087 193 dbSNP
rs200002596 198 dbSNP
rs139462473 210 dbSNP
rs996974825 219 dbSNP
rs899596360 224 dbSNP
rs1285907572 238 dbSNP
rs4648290 247 dbSNP
rs1271131520 248 dbSNP
rs540976562 249 dbSNP
rs903107670 250 dbSNP
rs199817349 262 dbSNP
rs1161144852 265 dbSNP
rs1440199239 275 dbSNP
rs1369594676 282 dbSNP
rs36233646 282 dbSNP
rs4648291 282 dbSNP
rs61352290 282 dbSNP
rs947210160 286 dbSNP
rs936684346 287 dbSNP
rs576764583 292 dbSNP
rs1042657737 300 dbSNP
rs1055651346 306 dbSNP
rs1051896 318 dbSNP
rs933565810 320 dbSNP
rs1455362514 321 dbSNP
rs1267533451 340 dbSNP
rs1412417684 341 dbSNP
rs762245176 342 dbSNP
rs1204052239 344 dbSNP
rs1341051995 352 dbSNP
rs926730007 355 dbSNP
rs1268131177 361 dbSNP
rs201916655 367 dbSNP
rs142234315 369 dbSNP
rs1279922005 378 dbSNP
rs199740331 379 dbSNP
rs1345782695 382 dbSNP
rs908779307 392 dbSNP
rs201917851 399 dbSNP
rs910985031 410 dbSNP
rs983836365 417 dbSNP
rs5275 427 dbSNP
rs867897544 431 dbSNP
rs199629276 433 dbSNP
rs918251275 441 dbSNP
rs13306031 450 dbSNP
rs1168795556 454 dbSNP
rs1486127728 460 dbSNP
rs1464093581 464 dbSNP
rs1173888940 469 dbSNP
rs1232462189 474 dbSNP
rs1373484287 476 dbSNP
rs1027536428 477 dbSNP
rs572939749 479 dbSNP
rs1399983283 482 dbSNP
rs975617247 483 dbSNP
rs201419014 489 dbSNP
rs972676320 496 dbSNP
rs1302931548 497 dbSNP
rs5276 498 dbSNP
rs199506254 499 dbSNP
rs201484578 507 dbSNP
rs1235504665 510 dbSNP
rs1290682004 524 dbSNP
rs536428606 531 dbSNP
rs1350060523 533 dbSNP
rs200416386 535 dbSNP
rs1012095900 559 dbSNP
rs959432847 570 dbSNP
rs201842290 581 dbSNP
rs762269568 582 dbSNP
rs1431028196 586 dbSNP
rs747223702 590 dbSNP
rs138908498 594 dbSNP
rs201014322 596 dbSNP
rs1469212354 597 dbSNP
rs1156824509 601 dbSNP
rs200207384 602 dbSNP
rs1436292614 611 dbSNP
rs1377866528 613 dbSNP
rs1020140798 615 dbSNP
rs1325047228 616 dbSNP
rs1426337078 617 dbSNP
rs201745115 618 dbSNP
rs1011885270 619 dbSNP
rs867946410 620 dbSNP
rs1488905983 626 dbSNP
rs201083629 627 dbSNP
rs4648292 629 dbSNP
rs1213623207 645 dbSNP
rs538701450 647 dbSNP
rs1489685391 651 dbSNP
rs4648293 678 dbSNP
rs1267665607 685 dbSNP
rs1256920855 702 dbSNP
rs1179467683 704 dbSNP
rs1227027072 705 dbSNP
rs1472837375 706 dbSNP
rs201104814 713 dbSNP
rs943555930 726 dbSNP
rs1459275852 738 dbSNP
rs115973952 741 dbSNP
rs909330860 748 dbSNP
rs534809418 749 dbSNP
rs1396106343 759 dbSNP
rs201782015 761 dbSNP
rs1297906652 764 dbSNP
rs1400622505 767 dbSNP
rs1048208718 778 dbSNP
rs1351197467 790 dbSNP
rs1354760511 792 dbSNP
rs4648294 797 dbSNP
rs1323844260 805 dbSNP
rs1246044864 806 dbSNP
rs1310945993 808 dbSNP
rs200795899 809 dbSNP
rs1480141828 811 dbSNP
rs1416426282 814 dbSNP
rs1051897 815 dbSNP
rs931525283 816 dbSNP
rs920194904 820 dbSNP
rs1460203848 828 dbSNP
rs975986038 833 dbSNP
rs931040508 838 dbSNP
rs1425313737 842 dbSNP
rs199858950 859 dbSNP
rs201688357 862 dbSNP
rs200717726 869 dbSNP
rs199740165 870 dbSNP
rs1170738988 873 dbSNP
rs1371196229 877 dbSNP
rs201588251 879 dbSNP
rs193144472 881 dbSNP
rs199657133 892 dbSNP
rs1444610035 893 dbSNP
rs1382033873 910 dbSNP
rs1396964607 915 dbSNP
rs967119738 916 dbSNP
rs201157576 919 dbSNP
rs200351050 926 dbSNP
rs201923503 930 dbSNP
rs201467945 938 dbSNP
rs1195588566 939 dbSNP
rs200400596 940 dbSNP
rs1342214554 944 dbSNP
rs917849791 946 dbSNP
rs991105879 950 dbSNP
rs1260176807 953 dbSNP
rs959274338 962 dbSNP
rs778888429 966 dbSNP
rs1484233374 970 dbSNP
rs202215792 976 dbSNP
rs1182389508 982 dbSNP
rs747178658 982 dbSNP
rs780260168 983 dbSNP
rs1260717305 989 dbSNP
rs1447465691 995 dbSNP
rs1190717827 997 dbSNP
rs957513961 998 dbSNP
rs1434166244 1004 dbSNP
rs1174126476 1008 dbSNP
rs1334204444 1020 dbSNP
rs1288822807 1021 dbSNP
rs530994465 1024 dbSNP
rs966746121 1028 dbSNP
rs1416596446 1030 dbSNP
rs1340979450 1036 dbSNP
rs1020970203 1050 dbSNP
rs2206593 1056 dbSNP
rs1365548917 1057 dbSNP
rs552048991 1058 dbSNP
rs1398210495 1069 dbSNP
rs1331559094 1071 dbSNP
rs1275822599 1072 dbSNP
rs2853804 1076 dbSNP
rs1039288018 1080 dbSNP
rs199859157 1084 dbSNP
rs1415083181 1085 dbSNP
rs1013645474 1093 dbSNP
rs150239498 1096 dbSNP
rs202024704 1100 dbSNP
rs887976350 1113 dbSNP
rs1210415890 1117 dbSNP
rs564911033 1123 dbSNP
rs540204815 1127 dbSNP
rs201042127 1139 dbSNP
rs1453935948 1140 dbSNP
rs1166443920 1150 dbSNP
rs4648295 1154 dbSNP
rs1427300798 1155 dbSNP
rs1433878116 1160 dbSNP
rs1158982687 1168 dbSNP
rs200089422 1170 dbSNP
rs1181562118 1173 dbSNP
rs560946853 1178 dbSNP
rs1321723170 1189 dbSNP
rs749068028 1200 dbSNP
rs201908600 1203 dbSNP
rs1435248253 1205 dbSNP
rs200729681 1210 dbSNP
rs918354162 1211 dbSNP
rs1272749480 1213 dbSNP
rs1369057612 1227 dbSNP
rs1036749323 1228 dbSNP
rs1047059982 1230 dbSNP
rs1287633069 1233 dbSNP
rs1327071269 1236 dbSNP
rs199966067 1238 dbSNP
rs949083088 1243 dbSNP
rs202003593 1245 dbSNP
rs200679193 1246 dbSNP
rs1468188451 1260 dbSNP
rs1248716547 1264 dbSNP
rs942845277 1267 dbSNP
rs937912400 1269 dbSNP
rs986943163 1276 dbSNP
rs1473819968 1281 dbSNP
rs1160580909 1284 dbSNP
rs1230098187 1286 dbSNP
rs1417541080 1287 dbSNP
rs967060958 1287 dbSNP
rs925141076 1296 dbSNP
rs979252370 1298 dbSNP
rs190150368 1302 dbSNP
rs184845240 1303 dbSNP
rs1306798151 1309 dbSNP
rs1236652309 1310 dbSNP
rs200577098 1312 dbSNP
rs1288949457 1320 dbSNP
rs1355342927 1326 dbSNP
rs1309682894 1328 dbSNP
rs1292278754 1331 dbSNP
rs796428843 1331 dbSNP
rs11567829 1335 dbSNP
rs201576572 1349 dbSNP
rs200295049 1351 dbSNP
rs1018011742 1359 dbSNP
rs568478222 1360 dbSNP
rs577829403 1364 dbSNP
rs202004599 1367 dbSNP
rs201595920 1374 dbSNP
rs971314478 1380 dbSNP
rs888049834 1385 dbSNP
rs200409468 1389 dbSNP
rs1165426272 1391 dbSNP
rs1391826411 1406 dbSNP
rs1414979176 1409 dbSNP
rs1424833975 1412 dbSNP
rs1327341470 1413 dbSNP
rs4648296 1417 dbSNP
rs1368120165 1419 dbSNP
rs4648297 1426 dbSNP
rs1308541255 1429 dbSNP
rs1158460747 1441 dbSNP
rs1339865532 1442 dbSNP
rs1469027651 1443 dbSNP
rs199947679 1444 dbSNP
rs1445540027 1445 dbSNP
rs897958246 1448 dbSNP
rs1179639250 1450 dbSNP
rs1356804409 1451 dbSNP
rs202217156 1451 dbSNP
rs1036822095 1458 dbSNP
rs1025762999 1460 dbSNP
rs887190876 1460 dbSNP
rs1454050687 1463 dbSNP
rs1278527294 1464 dbSNP
rs1441121819 1477 dbSNP
rs949149967 1478 dbSNP
rs1251309279 1479 dbSNP
rs1190232612 1480 dbSNP
rs201238205 1482 dbSNP
rs1449279931 1483 dbSNP
rs368833559 1485 dbSNP
rs1187514040 1500 dbSNP
rs13306032 1505 dbSNP
rs1283610257 1519 dbSNP
rs1168061200 1520 dbSNP
rs1055180218 1527 dbSNP
rs1203365875 1532 dbSNP
rs937654193 1545 dbSNP
rs1412627963 1546 dbSNP
rs930226257 1548 dbSNP
rs925214068 1556 dbSNP
rs1309790077 1558 dbSNP
rs979283304 1559 dbSNP
rs187958342 1566 dbSNP
rs913732925 1567 dbSNP
rs541341893 1579 dbSNP
rs976223976 1580 dbSNP
rs1342984864 1582 dbSNP
rs13306033 1583 dbSNP
rs759297172 1584 dbSNP
rs1464714789 1593 dbSNP
rs183653397 1596 dbSNP
rs182127940 1598 dbSNP
rs200069207 1608 dbSNP
rs1193472566 1609 dbSNP
rs1376527740 1615 dbSNP
rs1363002297 1616 dbSNP
rs201601925 1621 dbSNP
rs1027912147 1626 dbSNP
rs200482826 1628 dbSNP
rs199602058 1630 dbSNP
rs1456502594 1637 dbSNP
rs13306035 1638 dbSNP
rs1318218175 1640 dbSNP
rs192334329 1645 dbSNP
rs1393535595 1647 dbSNP
rs1390576462 1652 dbSNP
rs1382938113 1655 dbSNP
rs1193184145 1657 dbSNP
rs200828213 1660 dbSNP
rs1329388590 1661 dbSNP
rs1013359939 1666 dbSNP
rs199505687 1671 dbSNP
rs528082472 1679 dbSNP
rs201377863 1682 dbSNP
rs1489230800 1687 dbSNP
rs1286582254 1690 dbSNP
rs200312413 1691 dbSNP
rs561009903 1692 dbSNP
rs199736988 1694 dbSNP
rs1465649521 1708 dbSNP
rs1205314609 1717 dbSNP
rs1266291707 1735 dbSNP
rs201532679 1741 dbSNP
rs1449364477 1745 dbSNP
rs200177856 1746 dbSNP
rs756045952 1750 dbSNP
rs1429385764 1753 dbSNP
rs202009206 1758 dbSNP
rs201231127 1762 dbSNP
rs1345424455 1771 dbSNP
rs200492640 1777 dbSNP
rs1043661868 1785 dbSNP
rs945286060 1787 dbSNP
rs1156883201 1793 dbSNP
rs1219497323 1794 dbSNP
rs202243625 1795 dbSNP
rs200779240 1796 dbSNP
rs913760176 1799 dbSNP
rs1338331226 1801 dbSNP
rs4648298 1803 dbSNP
rs1303770680 1805 dbSNP
rs1349965413 1812 dbSNP
rs1408486352 1812 dbSNP
rs1290787849 1814 dbSNP
rs201526173 1816 dbSNP
rs1244591599 1820 dbSNP
rs575211762 1821 dbSNP
rs910637375 1835 dbSNP
rs1264486126 1836 dbSNP
rs11384450 1838 dbSNP
rs1353738052 1838 dbSNP
rs200986059 1838 dbSNP
rs397804274 1838 dbSNP
rs1299300183 1841 dbSNP
rs1414670490 1843 dbSNP
rs1357834837 1845 dbSNP
rs1482457898 1851 dbSNP
rs199850911 1856 dbSNP
rs1253955492 1857 dbSNP
rs3835508 1857 dbSNP
rs2853805 1859 dbSNP
rs986193283 1862 dbSNP
rs1418985556 1863 dbSNP
rs1163896699 1866 dbSNP
rs898588734 1869 dbSNP
rs952065571 1875 dbSNP
rs11567830 1876 dbSNP
rs200845455 1887 dbSNP
rs3179567 1893 dbSNP
rs1187188354 1895 dbSNP
rs4648299 1908 dbSNP
rs1374777503 1916 dbSNP
rs1239048927 1917 dbSNP
rs1395961530 1922 dbSNP
rs552834364 1946 dbSNP
rs201917612 1949 dbSNP
rs1342656364 1956 dbSNP
rs200531158 1958 dbSNP
rs1292099548 1960 dbSNP
rs866949664 1962 dbSNP
rs868072785 1963 dbSNP
rs1480882050 1964 dbSNP
rs946200250 1969 dbSNP
rs891937164 1977 dbSNP
rs1055043699 1990 dbSNP
rs935728324 1999 dbSNP
rs958865775 2007 dbSNP
rs1270377952 2008 dbSNP
rs1219966438 2009 dbSNP
rs1170493008 2014 dbSNP
rs541069205 2024 dbSNP
rs1355198830 2027 dbSNP
rs1318049786 2031 dbSNP
rs1465933534 2043 dbSNP
rs199626279 2044 dbSNP
rs201415472 2053 dbSNP
rs1453896412 2065 dbSNP
rs1292108556 2070 dbSNP
rs1364099708 2070 dbSNP
rs1233269572 2072 dbSNP
rs4648300 2074 dbSNP
rs199834448 2077 dbSNP
rs1043357432 2081 dbSNP
rs201360946 2087 dbSNP
rs188254107 2089 dbSNP
rs202089327 2090 dbSNP
rs1040259792 2095 dbSNP
rs944540982 2100 dbSNP
rs1447825207 2104 dbSNP
rs201006478 2109 dbSNP
rs1190778026 2117 dbSNP
rs910383471 2121 dbSNP
rs4648301 2127 dbSNP
rs1424487359 2128 dbSNP
rs201730694 2129 dbSNP
rs930703158 2131 dbSNP
rs1164290244 2138 dbSNP
rs200883517 2140 dbSNP
rs1470506534 2141 dbSNP
rs200097577 2144 dbSNP
rs1027460862 2145 dbSNP
rs1415790734 2151 dbSNP
rs1432382992 2153 dbSNP
rs1290298623 2154 dbSNP
rs973653223 2155 dbSNP
rs920617681 2157 dbSNP
rs183201650 2167 dbSNP
rs200985751 2168 dbSNP
rs200027430 2169 dbSNP
rs1224063085 2181 dbSNP
rs1267204525 2181 dbSNP
rs962041418 2182 dbSNP
rs1463399234 2183 dbSNP
rs547558694 2188 dbSNP
rs1018808713 2192 dbSNP
rs1457923425 2201 dbSNP
rs1272059398 2208 dbSNP
rs917496771 2209 dbSNP
rs1481019136 2211 dbSNP
rs993053036 2211 dbSNP
rs689467 2212 dbSNP
rs955397215 2216 dbSNP
rs689468 2220 dbSNP
rs1345480453 2224 dbSNP
rs1435311796 2225 dbSNP
rs199854202 2233 dbSNP
rs1010413923 2239 dbSNP
rs369883147 2246 dbSNP
rs1346872887 2253 dbSNP
rs201684522 2254 dbSNP
rs1021972937 2255 dbSNP
rs1326783710 2256 dbSNP
rs1225307913 2258 dbSNP
rs892048890 2260 dbSNP
rs1321281115 2263 dbSNP
rs4648302 2267 dbSNP
rs1000808915 2272 dbSNP
rs1490544396 2275 dbSNP
rs892093631 2276 dbSNP
rs905607000 2282 dbSNP
rs4648303 2287 dbSNP
rs689469 2288 dbSNP
rs1413538661 2289 dbSNP
rs1404342002 2300 dbSNP
rs916897783 2301 dbSNP
rs1366857530 2305 dbSNP
rs1047442397 2313 dbSNP
rs200642986 2326 dbSNP
rs191788711 2328 dbSNP
rs1444301933 2335 dbSNP
rs1050234311 2341 dbSNP
rs1226786882 2344 dbSNP
rs1378205188 2344 dbSNP
rs1294273033 2345 dbSNP
rs1360229625 2348 dbSNP
rs1378315781 2351 dbSNP
rs201156755 2354 dbSNP
rs1204598565 2357 dbSNP
rs13306038 2358 dbSNP
rs201931599 2359 dbSNP
rs559089418 2359 dbSNP
rs973252089 2359 dbSNP
rs1386764727 2360 dbSNP
rs985486279 2363 dbSNP
rs1368183445 2364 dbSNP
rs201061872 2365 dbSNP
rs200428982 2368 dbSNP
rs149091810 2369 dbSNP
rs1491075518 2369 dbSNP
rs1491267349 2369 dbSNP
rs202092932 2369 dbSNP
rs371722469 2369 dbSNP
rs57974311 2369 dbSNP
rs757813906 2369 dbSNP
rs1227951645 2372 dbSNP
rs201348126 2379 dbSNP
rs1439921235 2380 dbSNP
rs185983564 2381 dbSNP
rs1196855345 2387 dbSNP
rs1036413690 2389 dbSNP
rs1251924543 2394 dbSNP
rs1278592927 2397 dbSNP
rs545225542 2399 dbSNP
rs1211300606 2408 dbSNP
rs1441032420 2415 dbSNP
rs199824454 2417 dbSNP
rs689470 2427 dbSNP
rs1010193427 2428 dbSNP
rs956311365 2430 dbSNP
rs993519819 2432 dbSNP
rs201039864 2446 dbSNP
rs1168404947 2453 dbSNP
rs1424447085 2455 dbSNP
rs1468034534 2456 dbSNP
rs559271434 2457 dbSNP
rs1000357628 2463 dbSNP
rs927528179 2464 dbSNP
rs200076979 2466 dbSNP
rs372262132 2468 dbSNP
rs1284409655 2469 dbSNP
rs1274768081 2475 dbSNP
rs1343401757 2491 dbSNP
rs1242684837 2495 dbSNP
rs1225897781 2499 dbSNP
rs1377947112 2507 dbSNP
rs1464756628 2528 dbSNP
rs1302894092 2529 dbSNP
rs201913348 2533 dbSNP
rs200648161 2547 dbSNP
rs1448209923 2560 dbSNP
rs1013984453 2561 dbSNP
rs1245631430 2563 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions U87 , LN229
Location of target site 3'UTR
Tools used in this research miRanda
Original Description (Extracted from the article) ... miR-137 is able to inhibit Cox-2 protein expression through directly binding to 3' UTR region of Cox-2 mRNA. ...

- Chen L; Wang X; Wang H; Li Y; Yan W; Han L; et al., 2012, European journal of cancer (Oxford, England : 1990).

Article - Chen L; Wang X; Wang H; Li Y; Yan W; Han L; et al.
- European journal of cancer (Oxford, England : 1990), 2012
MicroRNAs are strongly implicated in cancer but their specific roles and functions in the major cancers have yet to be fully elucidated. In this study, we defined the expression and function of miR-137, which we found to be downregulated in glioma samples and glioma cells by qRT-PCR. Ectopic expression of miR-137 in glioma cell lines inhibited proliferation and invasion. Using computational and expression analysis, Cox-2 was identified as a candidate target of miR-137. Reporter assay with 3'UTR of Cox-2 cloned downstream of the luciferase gene showed reduced luciferase activity in the presence of miR-137, providing strong evidence that miR-137 was a direct regulator of Cox-2. Expression analysis further revealed that Cox-2 was elevated in glioma and associated with survival of patients. Furthermore, we observed that Cox-2 knockdown resulted in effects similar to those with miR-137 transfection in glioma cells. In conclusion, our study demonstrates that miR-137 deregulation is common in glioma, and restoration of its function inhibits cell proliferation and invasion, suggesting that miR-137 may act as a tumour suppressor.
LinkOut: [PMID: 22406049]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38974 Chronic obstructive pulmonary disease 0.555 2.0e-3 0.581 1.2e-3 25 Click to see details
GSE42095 Differentiated embryonic stem cells 0.547 3.5e-3 0.540 3.9e-3 23 Click to see details
GSE38226 Liver fibrosis -0.532 6.5e-3 -0.353 5.8e-2 21 Click to see details
GSE21687 Ependynoma primary tumors 0.278 1.3e-2 0.096 2.3e-1 64 Click to see details
GSE26953 Aortic valvular endothelial cells -0.402 2.6e-2 -0.316 6.6e-2 24 Click to see details
GSE19350 CNS germ cell tumors 0.412 9.2e-2 0.500 4.9e-2 12 Click to see details
GSE14794 Lymphoblastoid cells 0.133 1.1e-1 0.106 1.6e-1 90 Click to see details
GSE28544 Breast cancer -0.253 1.2e-1 -0.445 1.5e-2 24 Click to see details
GSE17498 Multiple myeloma 0.145 1.9e-1 0.138 2.0e-1 40 Click to see details
GSE28260 Renal cortex and medulla 0.255 2.0e-1 0.220 2.4e-1 13 Click to see details
GSE27834 Pluripotent stem cells -0.164 2.7e-1 -0.432 4.7e-2 16 Click to see details
GSE21849 B cell lymphoma 0.115 2.8e-1 0.500 2.9e-3 29 Click to see details
GSE32688 Pancreatic cancer -0.066 3.6e-1 -0.104 2.9e-1 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.031 4.5e-1 -0.420 3.3e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.031 4.5e-1 -0.420 3.3e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.031 4.5e-1 -0.420 3.3e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.031 4.5e-1 -0.420 3.3e-2 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC 0.76 0.02 0.893 0 7 Click to see details
HNSC 0.34 0.04 0.193 0.16 29 Click to see details
LIHC 0.988 0.05 0.500 0.33 3 Click to see details
BLCA -0.872 0.06 -0.800 0.1 4 Click to see details
CHOL 0.814 0.09 0.200 0.4 4 Click to see details
UCEC 0.59 0.21 0.400 0.3 4 Click to see details
STAD -0.239 0.22 0.302 0.16 13 Click to see details
KIRP 0.268 0.26 0.071 0.43 8 Click to see details
PRAD 0.12 0.29 0.255 0.11 24 Click to see details
PCPG 0.564 0.31 0.500 0.33 3 Click to see details
ESCA 0.377 0.31 0.400 0.3 4 Click to see details
KICH -0.356 0.32 0.000 0.5 4 Click to see details
THCA 0.088 0.33 -0.074 0.36 27 Click to see details
PAAD 0.271 0.36 -0.400 0.3 4 Click to see details
BRCA -0.051 0.46 0.086 0.44 6 Click to see details
BRCA -0.051 0.46 0.086 0.44 6 Click to see details
BRCA -0.051 0.46 0.086 0.44 6 Click to see details
BRCA -0.051 0.46 0.086 0.44 6 Click to see details
140 hsa-miR-137 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT002489 E2F6 E2F transcription factor 6 4 1
MIRT002490 CDK6 cyclin dependent kinase 6 4 7
MIRT004004 NCOA2 nuclear receptor coactivator 2 4 1
MIRT004579 KDM1A lysine demethylase 1A 5 3
MIRT005485 CDC42 cell division cycle 42 4 4
MIRT005605 CTBP1 C-terminal binding protein 1 4 1
MIRT005883 MITF melanogenesis associated transcription factor 3 1
MIRT006329 PTGS2 prostaglandin-endoperoxide synthase 2 2 1
MIRT006957 ESRRA estrogen related receptor alpha 1 1
MIRT007068 ZNF804A zinc finger protein 804A 1 1
MIRT007092 YBX1 Y-box binding protein 1 3 3
MIRT007252 CSE1L chromosome segregation 1 like 2 1
MIRT007346 PXN paxillin 3 1
MIRT053056 GLIPR1 GLI pathogenesis related 1 3 1
MIRT053225 MET MET proto-oncogene, receptor tyrosine kinase 3 1
MIRT054547 FUNDC1 FUN14 domain containing 1 3 1
MIRT054568 BNIP3L BCL2 interacting protein 3 like 3 1
MIRT090615 PLS1 plastin 1 2 2
MIRT093393 TMA16 translation machinery associated 16 homolog 2 2
MIRT109230 VMA21 VMA21, vacuolar ATPase assembly factor 2 6
MIRT153687 NCOA3 nuclear receptor coactivator 3 2 2
MIRT170929 FOXK1 forkhead box K1 2 2
MIRT219251 RREB1 ras responsive element binding protein 1 2 2
MIRT259552 KLHL15 kelch like family member 15 2 4
MIRT271869 ZNF678 zinc finger protein 678 2 2
MIRT280623 BCL11B B-cell CLL/lymphoma 11B 2 8
MIRT293284 DR1 down-regulator of transcription 1 2 2
MIRT314017 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 8
MIRT374677 AGO4 argonaute 4, RISC catalytic component 2 2
MIRT437385 FMNL2 formin like 2 1 1
MIRT437406 RORA RAR related orphan receptor A 1 1
MIRT437423 KIT KIT proto-oncogene receptor tyrosine kinase 3 1
MIRT437424 AKT2 AKT serine/threonine kinase 2 5 4
MIRT437425 TGFB2 transforming growth factor beta 2 3 1
MIRT437804 SERPINA3 serpin family A member 3 1 1
MIRT437978 COX2 cytochrome c oxidase subunit II 3 1
MIRT438078 TRIM13 tripartite motif containing 13 4 1
MIRT438287 TBX3 T-box 3 1 1
MIRT438288 KLF4 Kruppel like factor 4 1 1
MIRT438537 MTDH metadherin 2 1
MIRT438757 Nr1i3 nuclear receptor subfamily 1, group I, member 3 2 1
MIRT442564 CCDC59 coiled-coil domain containing 59 2 2
MIRT442778 JAG1 jagged 1 2 2
MIRT444302 SREK1IP1 SREK1 interacting protein 1 2 2
MIRT446969 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT448824 FKBP1A FK506 binding protein 1A 2 4
MIRT453617 SNRPE small nuclear ribonucleoprotein polypeptide E 2 4
MIRT459217 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT463490 ZC3H11A zinc finger CCCH-type containing 11A 2 12
MIRT470084 PTGES2 prostaglandin E synthase 2 2 2
MIRT475876 H3F3C H3 histone family member 3C 2 10
MIRT475912 H3F3B H3 histone family member 3B 2 8
MIRT476669 FUT11 fucosyltransferase 11 2 10
MIRT477346 EOGT EGF domain specific O-linked N-acetylglucosamine transferase 2 4
MIRT477596 EIF1 eukaryotic translation initiation factor 1 2 10
MIRT478367 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT479111 CNN2 calponin 2 2 2
MIRT482926 CTPS2 CTP synthase 2 2 2
MIRT485083 SNRK SNF related kinase 2 12
MIRT497120 NBEAL1 neurobeachin like 1 2 2
MIRT498029 UBXN4 UBX domain protein 4 2 8
MIRT500603 UBE2Z ubiquitin conjugating enzyme E2 Z 2 4
MIRT500927 SSFA2 sperm specific antigen 2 2 8
MIRT504324 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT504647 RPL9 ribosomal protein L9 2 6
MIRT506304 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT508007 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT510538 XKR7 XK related 7 2 2
MIRT513051 LYPD6 LY6/PLAUR domain containing 6 2 6
MIRT515223 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT519857 ZFP62 ZFP62 zinc finger protein 2 6
MIRT520508 TRAM2 translocation associated membrane protein 2 2 6
MIRT522047 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT524479 CHRM3 cholinergic receptor muscarinic 3 2 4
MIRT526904 ZNF772 zinc finger protein 772 2 6
MIRT527862 SLC39A14 solute carrier family 39 member 14 2 2
MIRT528601 ZNF326 zinc finger protein 326 2 2
MIRT532950 ZNF24 zinc finger protein 24 2 4
MIRT536275 LMOD2 leiomodin 2 2 2
MIRT537045 GRAMD4 GRAM domain containing 4 2 2
MIRT537124 GOLGA3 golgin A3 2 4
MIRT538884 BTBD1 BTB domain containing 1 2 2
MIRT541457 AURKA aurora kinase A 2 2
MIRT542924 HOXC8 homeobox C8 2 2
MIRT544580 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT545175 RFTN2 raftlin family member 2 2 2
MIRT545248 GTF2E1 general transcription factor IIE subunit 1 2 2
MIRT546473 SLC1A5 solute carrier family 1 member 5 2 2
MIRT547523 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT548071 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548200 FNIP1 folliculin interacting protein 1 2 2
MIRT551216 CIDEC cell death inducing DFFA like effector c 2 2
MIRT553046 USP28 ubiquitin specific peptidase 28 2 2
MIRT553875 SUPT7L SPT7 like, STAGA complex gamma subunit 2 4
MIRT554026 SPCS3 signal peptidase complex subunit 3 2 2
MIRT554153 SLX4 SLX4 structure-specific endonuclease subunit 2 2
MIRT554192 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT554362 SFXN5 sideroflexin 5 2 4
MIRT555349 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT555822 PAX9 paired box 9 2 2
MIRT555866 PAIP1 poly(A) binding protein interacting protein 1 2 2
MIRT555931 NUP43 nucleoporin 43 2 2
MIRT555993 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT556429 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT556582 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT557220 HNRNPDL heterogeneous nuclear ribonucleoprotein D like 2 2
MIRT558490 DBN1 drebrin 1 2 2
MIRT560986 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT562291 GLO1 glyoxalase I 2 2
MIRT564093 TLR3 toll like receptor 3 2 2
MIRT565312 TMEM41A transmembrane protein 41A 2 2
MIRT565424 TEF TEF, PAR bZIP transcription factor 2 2
MIRT566946 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT572369 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT686211 ZNF267 zinc finger protein 267 2 2
MIRT686935 SFT2D3 SFT2 domain containing 3 2 2
MIRT687448 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT710856 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT719484 RBM27 RNA binding motif protein 27 2 2
MIRT719813 TXNDC17 thioredoxin domain containing 17 2 2
MIRT720076 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT723920 ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 2 2
MIRT731305 CUL4A cullin 4A 3 1
MIRT732128 BMP7 bone morphogenetic protein 7 2 1
MIRT732466 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3 0
MIRT732962 TNC tenascin C 1 0
MIRT734856 KDM4A lysine demethylase 4A 3 0
MIRT735625 MEF2A myocyte enhancer factor 2A 2 0
MIRT735795 IL6 interleukin 6 3 0
MIRT736333 DELE1 KIAA0141 2 0
MIRT736610 RUNX2 runt related transcription factor 2 3 0
MIRT736830 NOTCH1 notch 1 3 0
MIRT736888 KCNA2 potassium voltage-gated channel subfamily A member 2 3 0
MIRT737349 EGFR epidermal growth factor receptor 3 0
MIRT755368 GLS glutaminase 2 1
MIRT755431 SPHK2 sphingosine kinase 2 3 1
MIRT756119 USP30 ubiquitin specific peptidase 30 4 1
MIRT756144 XIAP X-linked inhibitor of apoptosis 3 1
MIRT756170 COL5A1 collagen type V alpha 1 chain 3 1
MIRT756171 FSTL1 follistatin like 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-137 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-137 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-137 Emodin NULL 3220 Microarray K562 cells 23744534 2013 down-regualted
miR-137 Emodin NULL 3220 Quantitative real-time PCR K562 cells 23744534 2013 down-regualted
miR-137 Olea europaea leaf extract NULL NULL Quantitative real-time PCR Glioblastoma multiforme tumors cell lines 25232498 2014 up-regualted
miR-137 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-137 Ginsenoside Rh2 NULL 119307 Microarray human glioma cells U251 21372826 2011 up-regulated
miR-137 Interleukin 13 (IL-13) NULL NULL Quantitative real-time PCR esophageal squamous cells 22453679 2012 up-regulated
miR-137 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-137 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-137 Olea europaea leaf extract NULL NULL Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-137 Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-137 Nicotine approved 89594 Microarray Rat adrenal pheochromocytoma PC12 cell 18845019 2009 up-regulated
miR-137 Capecitabine approved 60953 Quantitative real-time PCR rectal cancer 18695884 2008 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-137 Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MDA-MB-231)
hsa-mir-137 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-137 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-137 Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-137 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-137 Topotecan 60699 NSC609699 approved resistant cell line (W1)

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