miRTarBase - #MIRT006419


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pre-miRNA Information
pre-miRNA hsa-mir-28   
Genomic Coordinates chr3: 188688781 - 188688866
Synonyms MIRN28, hsa-mir-28, miR-28, MIR28
Description Homo sapiens miR-28 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-28-5p
Sequence 14| AAGGAGCUCACAGUCUAUUGAG |35
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 3 + 188688795 29233923 MiREDiBase
A-to-I 5 3 + 188688798 29233923 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN18185224 6 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1466099417 7 dbSNP
rs1333243027 9 dbSNP
rs1211406812 12 dbSNP
rs1380324091 13 dbSNP
rs1350747725 14 dbSNP
rs564264103 17 dbSNP
rs1315387654 18 dbSNP
rs1380847802 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol E2F6   
Synonyms E2F-6
Description E2F transcription factor 6
Transcript NM_198256   
Expression
Putative miRNA Targets on E2F6
3'UTR of E2F6
(miRNA target sites are highlighted)		 
>E2F6|NM_198256|3'UTR
   1 TGGCATTTGAGAATTTATGTATCACTGAGTTTTTTGGGAATATCTTCGTGGAGAATTACGCATCAAATTTGATTCTCAGA
  81 GCAATAAATTATCCATGAAGTGCTCTCGTTCTCAGTAGCGGCATCATGGCCAGTAGTGTCTTTGAGGAGTTCACCACTTA
 161 GATTACTGAGTAATTGTGGTTTCCACATTTGAAAACAACTCCTTTTATAATTATTCACTGCTTTTTGTCAGTGAAATAGA
 241 CATCTTGCCTCCTGAAGTAGCTTCATCACAGAGTGTCATGAAGACAGACAGTCAGGCTGAAATGGACAGTTCTTTGTGGA
 321 CTCTACCCTTCCCTTCAAGGAGTATGTCATATATCACAAAAGAAATTGCCTTACACTGGTTCATGTTTGCAGTTACTGTT
 401 GTACATTGCATAGATGTACACACGAATTTAAATGTGATGTCTTTGTATATATCTGTATAATGTTGAGATTACTTACGAAA
 481 TATGTCTGAGTGACACTTTTCACCCTTGTACAGCCAAAATAATGTATATATGGAAAGTGACAGACAAATTCTCTAATCTC
 561 TTTGGTACCTATAACTTATTAGAATCCTCTGGATGAGGGTTAGAAGAGACTTTTTCCAAACTTCTACATGTAGAAGTATC
 641 ATAAATGTGCTACACATTTATGTTTGTGGATTTAATTAAAGTATTTTAATATGGTTTTCAGTGCTAAAATTGGAGTCAGA
 721 TACTTCTTGGTTTTAAGCTGTCTACCTAATTGCTGTCTCCCAGCAGACTGGTGGCATGCCCAGTGGCTTTGGGGGCAAGG
 801 ATAGAAATGCCATCAGGAAATAGCTGAATTCATTGTGAAACATGAATTCAGTCATGGTGATAATTGGAAACTCCTTTCAG
 881 GTTTTTGCAAGTAGATTTTGTAATGTTTGTGTATGCAGCCTTGCTGTTGAGTCAGTCCAAGGGGTTTTACTTAGGACAAG
 961 TTGTACCTTGCCCTCTCTCCAGCTCTGCTCCCACATTTTCACATACCTAGCTGTTTCTACCTCATTGGGTAAGTCATTTA
1041 CCACTCTGTGCCTCAGTTTACTCTGTAGTTTACCATTAGACTGTGAGCTCCTTGAGGGACTTTGTCATAATCACTGTTAC
1121 ATCCCAGTGCCTCACACCATGCCTGGCCCTTAAGAAGTGCTCAATAAATGTCTGAACAAATAAGTGAGTGGAGTGAGTGA
1201 ATTGTAAGATCAGAATAATAATATTTGGTTTGTCTATCGTACAAGATTCCTGTATCGTTTGAATATTGCTTTTAAAGAAA
1281 TATTTGAAGCGACTTCAAATTCAGACTGTGTTTAAAAAGATTTAAAATCGGAATCCAAAATCAAAGTATTAAAAAATAAT
1361 GCTGAGTGTTTAGGATTCACATACCTCTGAGCTCTGGTGGCTTTTGCCAGTCCTGTCCCTCTGCTGAGCACCAGCCCTTC
1441 CTGCAGCAGTCCTGCCGGTGTGTTTCTGTGCACCTGGGGATGAAGTGTGCTCCTCCCCCAGCGGTTAGCCTCAATGCTTT
1521 TCCTCCCTCTGTTTTATTATTTGAAATTAGCCAAAGAAAAGCTGCAGGGGGCACTGCTGATCATCACTGGACTGGTGGGT
1601 CGTACTGTTTGACAGAATAGGGAATACAGGAGGAGGAGCAAGCCTAGGGTAAAACTTAGGTTTGGGACATGCTTGATGAA
1681 AGCAAGAGTTGAGCAGGTTGTTGTGTGTATGTAGGTCAGGTGCTCAGCGGAAAAGTCTGAGCTGTGTAGTACGTCAGGCA
1761 GATGTCAGTTTAGATGCGATAGTTTAAGCCACAAGAGTAGGAGAGGTCATCTAAAGAGTACAGCAGGCCTAAGGGCATCT
1841 ATATTTAAGGAGAAATACAGAAGAAGTCTCCTGAGAAGGAATAATGGGGCGGGTGGGGAGGGAGAAGGCAGTGTCCCAAA
1921 AACCAACAAAGGTTTTACCAAAGGTAATACCATCATTTCTGAGCAGCAGTTCCTTAACTTGTGAATGTGGCAAATGTTCT
2001 CCTTTACAAATTGTTCTGAAGGTAAAATGAGATCATGTAAACGAAAATCCTTTGTAAATTACAGATGTGTGTTATAAATG
2081 AAGTATCTCTCGAGTCACTCCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaGUUAUCUGACACUCGAGGAa 5'
            || |||||||||||||||| 
Target 5' acCATTAGACTGTGAGCTCCTt 3'
 1072 - 1093 192.00 -30.50
2 
miRNA  3' gagUUAUCUGACACUCGAGGAa 5'
             :||: | |||  |||||| 
Target 5' gggGATGAAGTGT--GCTCCTc 3'
 1476 - 1495 130.00 -14.20
3 
miRNA  3' gaGUUA-UCUGAC---AC---UCGAGGAa 5'
            ||:| ||:|||   ||   ||:||:| 
Target 5' gaCAGTCAGGCTGAAATGGACAGTTCTTt 3'
 287 - 315 128.00 -14.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30127735 48 COSMIC
COSN13930127 120 COSMIC
COSN30170674 186 COSMIC
COSN31564729 328 COSMIC
COSN28705221 384 COSMIC
COSN31571043 424 COSMIC
COSN26561585 472 COSMIC
COSN31961620 660 COSMIC
COSN19350529 793 COSMIC
COSN20903813 986 COSMIC
COSN16227297 1019 COSMIC
COSN26562312 1041 COSMIC
COSN7328977 1239 COSMIC
COSN21782622 1268 COSMIC
COSN29950848 1811 COSMIC
COSN9073535 2013 COSMIC
COSN32065433 2037 COSMIC
rs1047392 384 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs754945668 2 dbSNP
rs753044171 3 dbSNP
rs781333322 11 dbSNP
rs1311606096 15 dbSNP
rs755231264 18 dbSNP
rs751673273 25 dbSNP
rs747284605 27 dbSNP
rs560959422 28 dbSNP
rs1239379800 30 dbSNP
rs1275437272 36 dbSNP
rs763086890 38 dbSNP
rs753867441 40 dbSNP
rs1344051131 41 dbSNP
rs764101094 42 dbSNP
rs760605766 44 dbSNP
rs112341910 47 dbSNP
rs774624009 48 dbSNP
rs1174896991 52 dbSNP
rs1423861127 59 dbSNP
rs569484319 59 dbSNP
rs1177823175 60 dbSNP
rs1012750737 66 dbSNP
rs892932874 73 dbSNP
rs575306694 79 dbSNP
rs1352086530 87 dbSNP
rs1403104489 88 dbSNP
rs1208653643 92 dbSNP
rs1054225226 93 dbSNP
rs1353611530 96 dbSNP
rs1219842494 97 dbSNP
rs1280786624 103 dbSNP
rs1340363222 104 dbSNP
rs1204683787 105 dbSNP
rs1264407075 107 dbSNP
rs1244912753 108 dbSNP
rs1197389402 109 dbSNP
rs1246589681 113 dbSNP
rs1361103727 115 dbSNP
rs1192471778 119 dbSNP
rs552714154 120 dbSNP
rs1445697038 121 dbSNP
rs934716148 125 dbSNP
rs903294207 126 dbSNP
rs1372188645 133 dbSNP
rs1422459053 136 dbSNP
rs1051083345 144 dbSNP
rs1377448970 146 dbSNP
rs1330772998 149 dbSNP
rs1350436818 154 dbSNP
rs1438493006 168 dbSNP
rs1276744610 174 dbSNP
rs867318494 179 dbSNP
rs921516713 187 dbSNP
rs1227948412 194 dbSNP
rs1298535982 200 dbSNP
rs1208393329 201 dbSNP
rs1389952319 202 dbSNP
rs976107301 211 dbSNP
rs556433219 224 dbSNP
rs1245744475 230 dbSNP
rs1378635318 233 dbSNP
rs1391586298 235 dbSNP
rs1471586240 236 dbSNP
rs1158329973 239 dbSNP
rs1162483325 256 dbSNP
rs1391166499 266 dbSNP
rs1407079126 268 dbSNP
rs1440698147 270 dbSNP
rs771853817 272 dbSNP
rs1434403741 273 dbSNP
rs538487274 278 dbSNP
rs577603226 280 dbSNP
rs1242857600 286 dbSNP
rs1284037587 287 dbSNP
rs950431119 290 dbSNP
rs532617402 292 dbSNP
rs1209846826 296 dbSNP
rs981124267 301 dbSNP
rs971510549 302 dbSNP
rs1022632282 305 dbSNP
rs1012753066 310 dbSNP
rs773997109 321 dbSNP
rs189571566 333 dbSNP
rs1473622728 344 dbSNP
rs183996239 350 dbSNP
rs1411091976 356 dbSNP
rs1160063796 366 dbSNP
rs1387222006 368 dbSNP
rs1047392 384 dbSNP
rs903253538 392 dbSNP
rs1341461868 398 dbSNP
rs1051649756 405 dbSNP
rs934003009 408 dbSNP
rs899790155 412 dbSNP
rs1229533574 414 dbSNP
rs1269544618 415 dbSNP
rs55688939 419 dbSNP
rs1039713497 423 dbSNP
rs536310830 424 dbSNP
rs1443959334 439 dbSNP
rs1179801547 441 dbSNP
rs1358776490 443 dbSNP
rs1472912394 444 dbSNP
rs1161280988 447 dbSNP
rs1297789052 453 dbSNP
rs910161362 472 dbSNP
rs1464561722 476 dbSNP
rs982937734 476 dbSNP
rs930163398 477 dbSNP
rs1171148918 478 dbSNP
rs981559206 482 dbSNP
rs1410976775 492 dbSNP
rs1290691271 494 dbSNP
rs1231839441 495 dbSNP
rs971179404 499 dbSNP
rs12165224 504 dbSNP
rs915533770 516 dbSNP
rs1477910419 517 dbSNP
rs991132750 519 dbSNP
rs569341094 526 dbSNP
rs1483223902 532 dbSNP
rs957266812 534 dbSNP
rs1032919153 535 dbSNP
rs1432490167 536 dbSNP
rs1198304409 543 dbSNP
rs1378258885 550 dbSNP
rs1455797404 553 dbSNP
rs1166873388 558 dbSNP
rs1481113017 560 dbSNP
rs191583176 567 dbSNP
rs11203 568 dbSNP
rs1300452995 571 dbSNP
rs564813071 579 dbSNP
rs1285919258 582 dbSNP
rs546459775 594 dbSNP
rs998641683 599 dbSNP
rs1344107210 615 dbSNP
rs899935649 622 dbSNP
rs1342642635 626 dbSNP
rs1275362989 632 dbSNP
rs1263430992 640 dbSNP
rs1225317837 653 dbSNP
rs1488148501 655 dbSNP
rs1210352789 656 dbSNP
rs373978190 660 dbSNP
rs1005586316 666 dbSNP
rs1186933409 673 dbSNP
rs888694260 679 dbSNP
rs1450292201 681 dbSNP
rs1173053073 683 dbSNP
rs1367074225 689 dbSNP
rs1047384945 692 dbSNP
rs930215626 703 dbSNP
rs1396052426 705 dbSNP
rs928088262 706 dbSNP
rs1319512978 712 dbSNP
rs369121164 714 dbSNP
rs1215944671 715 dbSNP
rs528383811 719 dbSNP
rs915687045 732 dbSNP
rs1414251112 740 dbSNP
rs186783957 742 dbSNP
rs1274918403 764 dbSNP
rs12165151 768 dbSNP
rs12165239 769 dbSNP
rs749174746 771 dbSNP
rs1469902223 774 dbSNP
rs1403403218 778 dbSNP
rs1179177535 793 dbSNP
rs1465562241 795 dbSNP
rs529861706 796 dbSNP
rs1254518248 803 dbSNP
rs957067831 806 dbSNP
rs1423577763 814 dbSNP
rs1192218511 820 dbSNP
rs925868159 821 dbSNP
rs1243475130 841 dbSNP
rs977267602 844 dbSNP
rs1456087037 851 dbSNP
rs1157844897 853 dbSNP
rs1441602365 864 dbSNP
rs1279127686 866 dbSNP
rs575240301 867 dbSNP
rs1315944930 872 dbSNP
rs1378198378 878 dbSNP
rs1396352240 878 dbSNP
rs1257357872 879 dbSNP
rs967326697 883 dbSNP
rs1327056201 885 dbSNP
rs1227697869 887 dbSNP
rs1451597973 889 dbSNP
rs1267662732 893 dbSNP
rs1317527164 895 dbSNP
rs1219271317 900 dbSNP
rs563443600 909 dbSNP
rs1235899372 913 dbSNP
rs1483148347 913 dbSNP
rs1364246805 916 dbSNP
rs1260030167 918 dbSNP
rs1471933295 929 dbSNP
rs544797904 940 dbSNP
rs1029879512 942 dbSNP
rs1341318486 944 dbSNP
rs998055320 949 dbSNP
rs1339056335 950 dbSNP
rs1358257982 955 dbSNP
rs1466211528 959 dbSNP
rs577546934 966 dbSNP
rs1018407389 967 dbSNP
rs1005555122 973 dbSNP
rs1288165362 977 dbSNP
rs1225507234 980 dbSNP
rs1276536101 985 dbSNP
rs1311845046 990 dbSNP
rs1211788586 1003 dbSNP
rs1282999824 1006 dbSNP
rs888410132 1009 dbSNP
rs12165209 1013 dbSNP
rs1047102309 1019 dbSNP
rs994798519 1021 dbSNP
rs1421073743 1043 dbSNP
rs1161075007 1050 dbSNP
rs906802915 1054 dbSNP
rs1046981520 1055 dbSNP
rs1368537580 1065 dbSNP
rs370503599 1072 dbSNP
rs948274382 1075 dbSNP
rs915652483 1076 dbSNP
rs1055507373 1077 dbSNP
rs1243411730 1082 dbSNP
rs1185135217 1104 dbSNP
rs935753869 1107 dbSNP
rs1237484613 1120 dbSNP
rs1199271424 1124 dbSNP
rs1235376066 1130 dbSNP
rs12165150 1138 dbSNP
rs1305874096 1143 dbSNP
rs1340535175 1148 dbSNP
rs1228171635 1153 dbSNP
rs1309307277 1154 dbSNP
rs925586182 1155 dbSNP
rs1219923036 1159 dbSNP
rs977067765 1162 dbSNP
rs1360638290 1164 dbSNP
rs1227838536 1166 dbSNP
rs945938455 1169 dbSNP
rs922575377 1176 dbSNP
rs976985269 1186 dbSNP
rs968958391 1204 dbSNP
rs1317444011 1205 dbSNP
rs912869270 1211 dbSNP
rs988467103 1216 dbSNP
rs1403605564 1217 dbSNP
rs1322800241 1218 dbSNP
rs984171549 1221 dbSNP
rs1441693878 1224 dbSNP
rs185018108 1227 dbSNP
rs534464243 1229 dbSNP
rs1332592636 1234 dbSNP
rs1035486646 1236 dbSNP
rs1348671938 1238 dbSNP
rs573482860 1239 dbSNP
rs969883808 1246 dbSNP
rs1341904810 1248 dbSNP
rs1025626928 1250 dbSNP
rs1320969376 1253 dbSNP
rs756163793 1257 dbSNP
rs554624820 1259 dbSNP
rs768055439 1262 dbSNP
rs1215051837 1273 dbSNP
rs1245611009 1283 dbSNP
rs1464168139 1288 dbSNP
rs536687550 1290 dbSNP
rs995401597 1291 dbSNP
rs897089455 1303 dbSNP
rs569233176 1304 dbSNP
rs1379501404 1312 dbSNP
rs1036343627 1319 dbSNP
rs1004924139 1329 dbSNP
rs550697222 1330 dbSNP
rs895277079 1336 dbSNP
rs1053887528 1343 dbSNP
rs935721310 1346 dbSNP
rs1220848498 1348 dbSNP
rs1446232319 1351 dbSNP
rs193068999 1357 dbSNP
rs571082472 1358 dbSNP
rs1041765834 1366 dbSNP
rs775137907 1367 dbSNP
rs367662768 1376 dbSNP
rs1353407529 1390 dbSNP
rs746786066 1406 dbSNP
rs945768386 1409 dbSNP
rs1310390531 1415 dbSNP
rs922509506 1421 dbSNP
rs546394286 1425 dbSNP
rs976659319 1432 dbSNP
rs1440301263 1438 dbSNP
rs1186608918 1442 dbSNP
rs1257895011 1443 dbSNP
rs1366026638 1452 dbSNP
rs1051822262 1455 dbSNP
rs932061789 1456 dbSNP
rs879444659 1457 dbSNP
rs528334345 1458 dbSNP
rs1159404850 1460 dbSNP
rs1387453680 1467 dbSNP
rs1412931442 1474 dbSNP
rs1356421271 1479 dbSNP
rs911030220 1481 dbSNP
rs1286981926 1482 dbSNP
rs1365734035 1484 dbSNP
rs1349384409 1485 dbSNP
rs1043628614 1486 dbSNP
rs1280741508 1489 dbSNP
rs1417425585 1490 dbSNP
rs1199462358 1491 dbSNP
rs1280865107 1493 dbSNP
rs1486521855 1498 dbSNP
rs867766979 1502 dbSNP
rs1359529995 1503 dbSNP
rs1419556818 1503 dbSNP
rs913510595 1504 dbSNP
rs1365546567 1507 dbSNP
rs988434073 1511 dbSNP
rs1477163221 1513 dbSNP
rs142376780 1514 dbSNP
rs1376498914 1516 dbSNP
rs928299712 1518 dbSNP
rs973136032 1524 dbSNP
rs1190610356 1527 dbSNP
rs779281807 1531 dbSNP
rs1392422772 1536 dbSNP
rs1330315661 1539 dbSNP
rs979839476 1547 dbSNP
rs970232593 1551 dbSNP
rs973708371 1554 dbSNP
rs1349834551 1561 dbSNP
rs188947988 1568 dbSNP
rs1273587712 1572 dbSNP
rs1012465585 1583 dbSNP
rs761828279 1587 dbSNP
rs148715349 1593 dbSNP
rs563220306 1602 dbSNP
rs1001019698 1613 dbSNP
rs904276098 1614 dbSNP
rs545089756 1620 dbSNP
rs1261534627 1623 dbSNP
rs1218315610 1624 dbSNP
rs1463005599 1630 dbSNP
rs768304089 1632 dbSNP
rs145157313 1635 dbSNP
rs900804059 1649 dbSNP
rs1220355803 1651 dbSNP
rs1325945795 1659 dbSNP
rs890423178 1662 dbSNP
rs779520720 1665 dbSNP
rs1432365240 1666 dbSNP
rs1294586369 1669 dbSNP
rs1030765268 1676 dbSNP
rs1263581219 1677 dbSNP
rs1355507043 1679 dbSNP
rs1213172182 1680 dbSNP
rs996245257 1684 dbSNP
rs1284597805 1691 dbSNP
rs1397591884 1693 dbSNP
rs1469998638 1696 dbSNP
rs771739300 1697 dbSNP
rs900611580 1700 dbSNP
rs1261544837 1702 dbSNP
rs1173212439 1705 dbSNP
rs1367266354 1705 dbSNP
rs1429459106 1705 dbSNP
rs942570694 1716 dbSNP
rs1339376896 1720 dbSNP
rs1043189014 1725 dbSNP
rs1455373836 1727 dbSNP
rs1455147728 1728 dbSNP
rs183447053 1729 dbSNP
rs1175242257 1735 dbSNP
rs1383741538 1735 dbSNP
rs778405270 1736 dbSNP
rs540836687 1739 dbSNP
rs1354760474 1743 dbSNP
rs145353287 1746 dbSNP
rs928299264 1752 dbSNP
rs555274945 1753 dbSNP
rs980190339 1756 dbSNP
rs1262679942 1759 dbSNP
rs753116745 1765 dbSNP
rs139734098 1766 dbSNP
rs116567929 1767 dbSNP
rs1188680442 1775 dbSNP
rs973892038 1777 dbSNP
rs1189258483 1795 dbSNP
rs1475168924 1795 dbSNP
rs991243620 1797 dbSNP
rs1326192191 1798 dbSNP
rs1455161527 1809 dbSNP
rs1157691002 1817 dbSNP
rs1345443572 1829 dbSNP
rs1454972981 1837 dbSNP
rs1300870784 1838 dbSNP
rs1374624206 1841 dbSNP
rs147434611 1842 dbSNP
rs755252900 1845 dbSNP
rs191669237 1851 dbSNP
rs1216237258 1852 dbSNP
rs1357491545 1864 dbSNP
rs1015439058 1870 dbSNP
rs1306480970 1870 dbSNP
rs986692351 1872 dbSNP
rs1383609521 1875 dbSNP
rs1376544155 1878 dbSNP
rs142795678 1879 dbSNP
rs1453109389 1882 dbSNP
rs1408134976 1884 dbSNP
rs1168519577 1885 dbSNP
rs1465168249 1886 dbSNP
rs763284157 1887 dbSNP
rs750732879 1890 dbSNP
rs996604971 1891 dbSNP
rs1172777471 1894 dbSNP
rs1176142757 1895 dbSNP
rs1407996592 1897 dbSNP
rs1422238302 1898 dbSNP
rs1418154430 1899 dbSNP
rs1255738729 1902 dbSNP
rs1410237128 1903 dbSNP
rs1184528208 1904 dbSNP
rs1462977682 1908 dbSNP
rs900583166 1913 dbSNP
rs1435071532 1915 dbSNP
rs966812923 1916 dbSNP
rs1236875414 1917 dbSNP
rs552740579 1924 dbSNP
rs1021550024 1926 dbSNP
rs534865663 1927 dbSNP
rs1011624490 1932 dbSNP
rs1374137105 1938 dbSNP
rs567427398 1942 dbSNP
rs1301495469 1944 dbSNP
rs1040697566 1946 dbSNP
rs1347381734 1946 dbSNP
rs549292839 1951 dbSNP
rs6712902 1952 dbSNP
rs763586272 1954 dbSNP
rs1313945314 1968 dbSNP
rs753155883 1979 dbSNP
rs1177924165 1989 dbSNP
rs1246424438 2007 dbSNP
rs1250992035 2009 dbSNP
rs1048379603 2012 dbSNP
rs1191405089 2015 dbSNP
rs1394132129 2029 dbSNP
rs1454408674 2031 dbSNP
rs931220221 2039 dbSNP
rs569640786 2042 dbSNP
rs907478676 2043 dbSNP
rs374206110 2044 dbSNP
rs1044063699 2046 dbSNP
rs1171038153 2049 dbSNP
rs1355235081 2053 dbSNP
rs1329191622 2062 dbSNP
rs1446015900 2066 dbSNP
rs1037283881 2068 dbSNP
rs949471030 2075 dbSNP
rs762022500 2080 dbSNP
rs551398009 2091 dbSNP
rs1214550509 2092 dbSNP
rs139583318 2092 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Mo7e
Location of target site 3'UTR
Original Description (Extracted from the article) ... "miR-28 and closely related miR-151 and miR-708 inhibit Tpodependent proliferation of Mo7e cells and target mRNAs coding for proteins involved in proliferation and apoptosis.//E2F6 (E2F transcription factor 6) was inhibited by miR-28 and -151 by 40% and 20% ...

- Girardot M; Pecquet C; Boukour S; Knoops L; et al., 2010, Blood.

Article - Girardot M; Pecquet C; Boukour S; Knoops L; et al.
- Blood, 2010
BCR-ABL negative myeloproliferative neoplasms (MPNs; polycythemia vera, essential thrombocythemia, primary myelofibrosis) are malignant diseases arising from a multipotent hematopoietic progenitor, frequently altered by JAK2 V617F or other JAK/STAT activating mutations. The thrombopoietin receptor (TpoR, MPL) is one of the major dimeric cytokine receptors that use JAK2 in the myeloid lineage, and was found to be down-modulated in certain MPN patients. We searched for negative regulators of MPL expression. Here we report that miR-28 targets the 3' untranslated (3'UTR) region of MPL, inhibiting its translation, as well as other proteins potentially involved in megakaryocyte differentiation, such as E2F6. Expression of miR-28 in CD34-derived megakaryocytes inhibited terminal differentiation. miR-28 was found to be overexpressed in platelets of a fraction of MPN patients, while it was expressed at constant low levels in platelets from healthy subjects. Constitutive activation of STAT5 leading to autonomous growth of hematopoietic cell lines was associated with increased miR-28 expression. We discuss how down-modulating MPL and other targets of miR-28, and of related miR-708 and miR-151, could contribute to MPN pathogenicity.
LinkOut: [PMID: 20445018]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_198256 | 3UTR | AGACUGUGAGCUCCUUGAGGGAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE14794 Lymphoblastoid cells -0.407 3.4e-5 -0.356 2.9e-4 90 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.501 1.2e-2 0.684 4.4e-4 20 Click to see details
GSE26953 Aortic valvular endothelial cells 0.425 1.9e-2 0.328 5.9e-2 24 Click to see details
GSE28544 Breast cancer 0.422 2.0e-2 0.506 5.8e-3 24 Click to see details
GSE17306 Multiple myeloma 0.259 3.6e-2 0.235 5.2e-2 49 Click to see details
GSE19783 ER+ ER+ breast cancer 0.397 4.2e-2 0.235 1.6e-1 20 Click to see details
GSE19350 CNS germ cell tumors -0.486 5.5e-2 -0.538 3.6e-2 12 Click to see details
GSE19536 Breast cancer 0.115 1.3e-1 0.050 3.1e-1 100 Click to see details
GSE27834 Pluripotent stem cells -0.263 1.6e-1 -0.176 2.6e-1 16 Click to see details
GSE28260 Renal cortex and medulla -0.288 1.7e-1 -0.165 3.0e-1 13 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.184 1.9e-1 0.254 1.1e-1 25 Click to see details
GSE38226 Liver fibrosis 0.2 1.9e-1 0.137 2.8e-1 21 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.277 2.4e-1 -0.167 3.3e-1 9 Click to see details
GSE17498 Multiple myeloma -0.111 2.5e-1 -0.112 2.5e-1 40 Click to see details
GSE19783 ER- ER- breast cancer 0.07 2.7e-1 -0.005 4.8e-1 79 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.118 2.9e-1 -0.012 4.8e-1 25 Click to see details
GSE21687 Ependynoma primary tumors -0.059 3.2e-1 -0.022 4.3e-1 64 Click to see details
GSE42095 Differentiated embryonic stem cells 0.069 3.8e-1 -0.035 4.4e-1 23 Click to see details
GSE21032 Prostate cancer 0.034 3.8e-1 -0.055 3.1e-1 83 Click to see details
GSE32688 Pancreatic cancer 0.002 5.0e-1 -0.052 3.9e-1 32 Click to see details
GSE32688 Pancreatic cancer 0.002 5.0e-1 -0.052 3.9e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
ESCA 0.706 0.01 0.645 0.02 11 Click to see details
PCPG -0.972 0.08 -1.000 0.5 3 Click to see details
KIRP -0.255 0.08 -0.163 0.19 32 Click to see details
UCEC 0.314 0.1 0.207 0.2 19 Click to see details
HNSC 0.201 0.1 0.170 0.14 42 Click to see details
BLCA -0.243 0.17 -0.261 0.15 18 Click to see details
CHOL 0.36 0.17 0.383 0.15 9 Click to see details
COAD -0.376 0.18 -0.333 0.21 8 Click to see details
BRCA 0.1 0.18 0.022 0.42 84 Click to see details
LUAD -0.273 0.2 -0.357 0.13 12 Click to see details
KIRC 0.103 0.2 0.084 0.25 68 Click to see details
LUSC 0.119 0.24 0.113 0.25 38 Click to see details
THCA -0.067 0.31 -0.074 0.29 59 Click to see details
PAAD -0.35 0.33 -0.600 0.2 4 Click to see details
CESC 0.281 0.41 -0.500 0.33 3 Click to see details
KICH -0.043 0.42 -0.138 0.26 25 Click to see details
PRAD 0.014 0.46 0.053 0.36 50 Click to see details
LIHC 0.007 0.48 -0.022 0.44 49 Click to see details
STAD -0.005 0.49 -0.078 0.34 32 Click to see details
STAD -0.005 0.49 -0.078 0.34 32 Click to see details
STAD -0.005 0.49 -0.078 0.34 32 Click to see details
82 hsa-miR-28-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000595 CDKN1A cyclin dependent kinase inhibitor 1A 4 1
MIRT006402 MPL MPL proto-oncogene, thrombopoietin receptor 3 1
MIRT006411 N4BP1 NEDD4 binding protein 1 1 1
MIRT006414 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 1 1
MIRT006416 TEX261 testis expressed 261 1 1
MIRT006418 MAPK1 mitogen-activated protein kinase 1 1 1
MIRT006419 E2F6 E2F transcription factor 6 1 1
MIRT049989 ZCCHC3 zinc finger CCHC-type containing 3 1 1
MIRT049990 TPM4 tropomyosin 4 1 1
MIRT049991 TULP4 tubby like protein 4 1 1
MIRT049992 SNX1 sorting nexin 1 1 1
MIRT049993 IMPDH1 inosine monophosphate dehydrogenase 1 1 1
MIRT049994 AAAS aladin WD repeat nucleoporin 1 1
MIRT049995 CENPV centromere protein V 1 1
MIRT049996 NRN1 neuritin 1 1 1
MIRT049997 GEMIN4 gem nuclear organelle associated protein 4 1 1
MIRT049998 ZBTB47 zinc finger and BTB domain containing 47 1 1
MIRT049999 UNG uracil DNA glycosylase 1 1
MIRT050000 CNN3 calponin 3 1 1
MIRT050001 KLHL12 kelch like family member 12 1 1
MIRT050002 TLK1 tousled like kinase 1 1 1
MIRT050003 SREBF2 sterol regulatory element binding transcription factor 2 4 1
MIRT050004 RAB36 RAB36, member RAS oncogene family 1 1
MIRT050005 ZNF106 zinc finger protein 106 1 1
MIRT050006 SETD7 SET domain containing lysine methyltransferase 7 1 1
MIRT050007 DENND4B DENN domain containing 4B 1 1
MIRT050008 CS citrate synthase 1 1
MIRT050009 CD276 CD276 molecule 1 1
MIRT050010 TUFM Tu translation elongation factor, mitochondrial 1 1
MIRT050011 SMYD1 SET and MYND domain containing 1 2 5
MIRT050012 SIK1 salt inducible kinase 1 1 1
MIRT054748 MAD2L1 mitotic arrest deficient 2 like 1 3 1
MIRT054749 BAG1 BCL2 associated athanogene 1 3 1
MIRT054750 RAP1B RAP1B, member of RAS oncogene family 3 1
MIRT317835 CCND3 cyclin D3 2 2
MIRT367642 ARHGAP42 Rho GTPase activating protein 42 2 4
MIRT443876 DDTL D-dopachrome tautomerase like 2 2
MIRT447544 RNF165 ring finger protein 165 2 2
MIRT447611 PCYOX1 prenylcysteine oxidase 1 2 2
MIRT447838 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448193 FAM168A family with sequence similarity 168 member A 2 2
MIRT448713 KLHL11 kelch like family member 11 2 2
MIRT450179 KLF7 Kruppel like factor 7 2 2
MIRT450312 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT460792 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT466332 THRA thyroid hormone receptor, alpha 2 2
MIRT467610 SLC7A5 solute carrier family 7 member 5 2 2
MIRT471609 PAQR5 progestin and adipoQ receptor family member 5 2 2
MIRT472144 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 4
MIRT476588 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT486265 LINC00346 long intergenic non-protein coding RNA 346 2 4
MIRT486480 TSC22D1 TSC22 domain family member 1 2 2
MIRT487978 IQSEC2 IQ motif and Sec7 domain 2 2 2
MIRT489428 TUBB2A tubulin beta 2A class IIa 2 2
MIRT500781 TMED4 transmembrane p24 trafficking protein 4 2 6
MIRT501235 SEMA4C semaphorin 4C 2 6
MIRT511045 NRF1 nuclear respiratory factor 1 2 2
MIRT512837 IER3 immediate early response 3 2 2
MIRT513091 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT513543 PRDM2 PR/SET domain 2 2 4
MIRT532391 UMPS uridine monophosphate synthetase 2 2
MIRT535846 MSI2 musashi RNA binding protein 2 2 2
MIRT537892 EDA2R ectodysplasin A2 receptor 2 2
MIRT552769 YIPF6 Yip1 domain family member 6 2 2
MIRT553549 TMEM167A transmembrane protein 167A 2 4
MIRT557228 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT566756 MORF4L1 mortality factor 4 like 1 2 2
MIRT567505 FOXJ3 forkhead box J3 2 2
MIRT568165 CCDC6 coiled-coil domain containing 6 2 2
MIRT570263 PRSS16 protease, serine 16 2 2
MIRT614727 TEAD3 TEA domain transcription factor 3 2 2
MIRT668894 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT691021 CRTC3 CREB regulated transcription coactivator 3 2 2
MIRT697421 ZFP91 ZFP91 zinc finger protein 2 2
MIRT711474 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT720189 CMC4 C-X9-C motif containing 4 2 2
MIRT720622 PIANP PILR alpha associated neural protein 2 2
MIRT731420 IGF1 insulin like growth factor 1 3 1
MIRT732850 LINC00265 long intergenic non-protein coding RNA 265 3 0
MIRT732851 PCNA proliferating cell nuclear antigen 3 0
MIRT736342 FOXO1 forkhead box O1 3 0
MIRT755341 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-28 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-28 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer HB2 22076154 2011 down-regulated
miR-28 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer MDA-MB231 22076154 2011 down-regulated
miR-28 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer SKBR3 22076154 2011 down-regulated
miR-28 Tamoxifen approved 2733526 Microarray rat liver 17343880 2007 down-regulated
miR-28 Tamoxifen approved 2733526 Quantitative real-time PCR rat liver 17343880 2007 down-regulated
miR-28 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-28 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
miR-28 Morphine approved 5288826 Quantitative real-time PCR HIV 21224041 2011 down-regulated
miR-28-5p Methamphetamine approved 10836 Quantitative real-time PCR CD4+ T cells 24434277 2014 up-regulated
miR-28-5p Trastuzumab approved NULL Microarray SKBR3 cells. 22384020 2012 up-regulated
miR-28-5p Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
miR-28-5p Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-28 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-28 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-mir-28 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-28 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-mir-28 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-28-5p 2-[[6-[[bis(carboxymethyl)amino]methyl]-4-[2-[4-(2-phenylethynyl)phenyl]ethynyl]pyridin-2-yl]methyl-(carboxymethyl)amino]acetic acid 369524 NSC641379 resistant
hsa-miR-28-5p 2-[3-hydroxy-4-(acetylamino)phenyl]benzothiazole 395431 NSC699969 resistant
hsa-miR-28-5p Kinetin riboside 3832 NSC120958 resistant
hsa-miR-28-5p Michicarcin NSC191959 resistant
hsa-miR-28-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-28-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-28-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved sensitive High Laryngeal Cancer cell line (Hep2)
hsa-miR-28-5p Gemcitabine 60750 NSC613327 approved resistant High Bladder Cancer cell line (RT4, J82,TCCSUP, UM-UC-3,RT112,CUBIII)
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved resistant High Breast Cancer tissue
hsa-miR-28-5p Epirubicin 41867 NSC256942 approved resistant High Breast Cancer tissue
hsa-miR-28-5p Doxorubicin 31703 NSC123127 approved sensitive High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-28-5p Taxane 9548828 sensitive High Prostate Cancer cell line (PC-3, PR200)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-28-5p Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-28-5p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-28-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-28-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-28-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-28-5p Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-28-5p Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-28-5p Testosterone+Exemestane resistant cell line (MCF-7)
hsa-miR-28-5p Testosterone+Letrozole resistant cell line (MCF-7)
hsa-miR-28-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-28-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-28-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-28-5p Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-28-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR70)
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR200)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-28-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (H460)

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