miRTarBase - #MIRT006639


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pre-miRNA Information
pre-miRNA hsa-mir-519c   
Genomic Coordinates chr19: 53686469 - 53686555
Description Homo sapiens miR-519c stem-loop
Comment The 5' arm of this precursor expresses a product related to miR-526 (previously named miR-526c here). Landgraf et al. confirm mature miRNA expression from both arms of the precursor .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-519c-3p
Sequence 54| AAAGUGCAUCUUUUUAGAGGAU |75
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 19 + 53686523 29233923 MiREDiBase
A-to-I 3 19 + 53686524 29233923 MiREDiBase
A-to-I 8 19 + 53686529 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1164669230 4 dbSNP
rs764425172 8 dbSNP
rs1377433094 10 dbSNP
rs751997873 19 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TIMP2   
Synonyms CSC-21K, DDC8
Description TIMP metallopeptidase inhibitor 2
Transcript NM_003255   
Expression
Putative miRNA Targets on TIMP2
3'UTR of TIMP2
(miRNA target sites are highlighted)		 
>TIMP2|NM_003255|3'UTR
   1 GCAGGCCTCCAACGCCCCTGTGGCCAACTGCAAAAAAAGCCTCCAAGGGTTTCGACTGGTCCAGCTCTGACATCCCTTCC
  81 TGGAAACAGCATGAATAAAACACTCATCCCATGGGTCCAAATTAATATGATTCTGCTCCCCCCTTCTCCTTTTAGACATG
 161 GTTGTGGGTCTGGAGGGAGACGTGGGTCCAAGGTCCTCATCCCATCCTCCCTCTGCCAGGCACTATGTGTCTGGGGCTTC
 241 GATCCTTGGGTGCAGGCAGGGCTGGGACACGCGGCTTCCCTCCCAGTCCCTGCCTTGGCACCGTCACAGATGCCAAGCAG
 321 GCAGCACTTAGGGATCTCCCAGCTGGGTTAGGGCAGGGCCTGGAAATGTGCATTTTGCAGAAACTTTTGAGGGTCGTTGC
 401 AAGACTGTGTAGCAGGCCTACCAGGTCCCTTTCATCTTGAGAGGGACATGGCCCTTGTTTTCTGCAGCTTCCACGCCTCT
 481 GCACTCCCTGCCCCTGGCAAGTGCTCCCATCGCCCCGGTGCCCACCATGAGCTCCCAGCACCTGACTCCCCCCACATCCA
 561 AGGGCAGCCTGGAACCAGTGGCTAGTTCTTGAAGGAGCCCCATCAATCCTATTAATCCTCAGAATTCCAGTGGGAGCCTC
 641 CCTCTGAGCCTTGTAGAAATGGGAGCGAGAAACCCCAGCTGAGCTGCGTTCCAGCCTCAGCTGAGTCTTTTTGGTCTGCA
 721 CCCACCCCCCCACCCCCCCCCCCCCGCCCACATGCTCCCCAGCTTGCAGGAGGAATCGGTGAGGTCCTGTCCTGAGGCTG
 801 CTGTCCGGGGCCGGTGGCTGCCCTCAAGGTCCCTTCCCTAGCTGCTGCGGTTGCCATTGCTTCTTGCCTGTTCTGGCATC
 881 AGGCACCTGGATTGAGTTGCACAGCTTTGCTTTATCCGGGCTTGTGTGCAGGGCCCGGCTGGGCTCCCCATCTGCACATC
 961 CTGAGGACAGAAAAAGCTGGGTCTTGCTGTGCCCTCCCAGGCTTAGTGTTCCCTCCCTCAAAGACTGACAGCCATCGTTC
1041 TGCACGGGGCTTTCTGCATGTGACGCCAGCTAAGCATAGTAAGAAGTCCAGCCTAGGAAGGGAAGGATTTTGGAGGTAGG
1121 TGGCTTTGGTGACACACTCACTTCTTTCTCAGCCTCCAGGACACTATGGCCTGTTTTAAGAGACATCTTATTTTTCTAAA
1201 GGTGAATTCTCAGATGATAGGTGAACCTGAGTTGCAGATATACCAACTTCTGCTTGTATTTCTTAAATGACAAAGATTAC
1281 CTAGCTAAGAAACTTCCTAGGGAACTAGGGAACCTATGTGTTCCCTCAGTGTGGTTTCCTGAAGCCAGTGATATGGGGGT
1361 TAGGATAGGAAGAACTTTCTCGGTAATGATAAGGAGAATCTCTTGTTTCCTCCCACCTGTGTTGTAAAGATAAACTGACG
1441 ATATACAGGCACATTATGTAAACATACACACGCAATGAAACCGAAGCTTGGCGGCCTGGGCGTGGTCTTGCAAAATGCTT
1521 CCAAAGCCACCTTAGCCTGTTCTATTCAGCGGCAACCCCAAAGCACCTGTTAAGACTCCTGACCCCCAAGTGGCATGCAG
1601 CCCCCATGCCCACCGGGACCTGGTCAGCACAGATCTTGATGACTTCCCTTTCTAGGGCAGACTGGGAGGGTATCCAGGAA
1681 TCGGCCCCTGCCCCACGGGCGTTTTCATGCTGTACAGTGACCTAAAGTTGGTAAGATGTCATAATGGACCAGTCCATGTG
1761 ATTTCAGTATATACAACTCCACCAGACCCCTCCAACCCATATAACACCCCACCCCTGTTCGCTTCCTGTATGGTGATATC
1841 ATATGTAACATTTACTCCTGTTTCTGCTGATTGTTTTTTTAATGTTTTGGTTTGTTTTTGACATCAGCTGTAATCATTCC
1921 TGTGCTGTGTTTTTTATTACCCTTGGTAGGTATTAGACTTGCACTTTTTTAAAAAAAGGTTTCTGCATCGTGGAAGCATT
2001 TGACCCAGAGTGGAACGCGTGGCCTATGCAGGTGGATTCCTTCAGGTCTTTCCTTTGGTTCTTTGAGCATCTTTGCTTTC
2081 ATTCGTCTCCCGTCTTTGGTTCTCCAGTTCAAATTATTGCAAAGTAAAGGATCTTTGAGTAGGTTCGGTCTGAAAGGTGT
2161 GGCCTTTATATTTGATCCACACACGTTGGTCTTTTAACCGTGCTGAGCAGAAAACAAAACAGGTTAAGAAGAGCCGGGTG
2241 GCAGCTGACAGAGGAAGCCGCTCAAATACCTTCACAATAAATAGTGGCAATATATATATAGTTTAAGAAGGCTCTCCATT
2321 TGGCATCGTTTAATTTATATGTTATGTTCTAAGCACAGCTCTCTTCTCCTATTTTCATCCTGCAAGCAACTCAAAATATT
2401 TAAAATAAAGTTTACATTGTAGTTATTTTCAAATCTTTGCTTGATAAGTATTAAGAAATATTGGACTTGCTGCCGTAATT
2481 TAAAGCTCTGTTGATTTTGTTTCCGTTTGGATTTTTGGGGGAGGGGAGCACTGTGTTTATGCTGGAATATGAAGTCTGAG
2561 ACCTTCCGGTGCTGGGAACACACAAGAGTTGTTGAAAGTTGACAAGCAGACTGCGCATGTCTCTGATGCTTTGTATCATT
2641 CTTGAGCAATCGCTCGGTCCGTGGACAATAAACAGTATTATCAAAGAGAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaGGAG--AUUU-U--UCU--ACGUGAAa 5'
            |||:  ||:: |  |||  ||||||| 
Target 5' acCCTTGGTAGGTATTAGACTTGCACTTt 3'
 1939 - 1967 150.00 -12.30
2 
miRNA  3' uaggaGAUUUUUCUACGUGAAa 5'
               ||::||| :||||:|| 
Target 5' agggcCTGGAAATGTGCATTTt 3'
 355 - 376 149.00 -12.40
3 
miRNA  3' uaggAGAUUUUUCU-ACGUGAAa 5'
              |: |:||| | || |||| 
Target 5' agtaTTAAGAAATATTGGACTTg 3'
 2447 - 2469 126.00 -5.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30190591 14 COSMIC
COSN26998616 31 COSMIC
COSN18740213 32 COSMIC
COSN30146774 52 COSMIC
COSN26601095 53 COSMIC
COSN31573537 54 COSMIC
COSN31568356 240 COSMIC
COSN31562703 270 COSMIC
COSN31513076 272 COSMIC
COSN31489085 309 COSMIC
COSN31517797 403 COSMIC
COSN26562213 413 COSMIC
COSN26602846 418 COSMIC
COSN31532090 474 COSMIC
COSN20721760 731 COSMIC
COSN27212708 731 COSMIC
COSN5420970 1039 COSMIC
COSN25592315 1416 COSMIC
COSN2456121 1492 COSMIC
COSN1729703 1781 COSMIC
COSN22612787 1963 COSMIC
COSN31595996 2121 COSMIC
COSN16495784 2132 COSMIC
COSN17468642 2189 COSMIC
COSN31565655 2289 COSMIC
COSN31583339 2316 COSMIC
COSN26106372 2327 COSMIC
COSN26642240 2392 COSMIC
COSN30169728 2402 COSMIC
COSN7456351 2415 COSMIC
COSN31520610 2435 COSMIC
COSN22317942 2535 COSMIC
COSN26720693 2567 COSMIC
COSN31545878 2606 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs781058075 1 dbSNP
rs1323784162 5 dbSNP
rs767734813 6 dbSNP
rs201679056 13 dbSNP
rs766341437 14 dbSNP
rs1392812256 15 dbSNP
rs887866871 19 dbSNP
rs1324461652 20 dbSNP
rs1312121188 30 dbSNP
rs1445155423 32 dbSNP
rs763090188 37 dbSNP
rs1047542101 39 dbSNP
rs746869895 39 dbSNP
rs768539562 39 dbSNP
rs1293653407 41 dbSNP
rs773699815 48 dbSNP
rs138996168 49 dbSNP
rs567836204 53 dbSNP
rs1038172572 54 dbSNP
rs906057019 64 dbSNP
rs1469650960 70 dbSNP
rs1214022771 73 dbSNP
rs757541371 74 dbSNP
rs916311507 76 dbSNP
rs1056210490 82 dbSNP
rs747233974 89 dbSNP
rs939115666 97 dbSNP
rs1194835743 100 dbSNP
rs1242242689 102 dbSNP
rs1164915181 112 dbSNP
rs371521602 120 dbSNP
rs1327621382 128 dbSNP
rs547793057 133 dbSNP
rs7224825 142 dbSNP
rs1380785696 143 dbSNP
rs935042857 147 dbSNP
rs914822045 149 dbSNP
rs1414169745 150 dbSNP
rs750027188 151 dbSNP
rs757211624 152 dbSNP
rs921799929 159 dbSNP
rs990253715 163 dbSNP
rs964162536 164 dbSNP
rs1365555274 169 dbSNP
rs570207832 176 dbSNP
rs1206587377 180 dbSNP
rs1008259219 181 dbSNP
rs1286279719 182 dbSNP
rs28731049 183 dbSNP
rs1485061772 185 dbSNP
rs1185083065 191 dbSNP
rs1432783037 193 dbSNP
rs1268349848 200 dbSNP
rs1195871387 203 dbSNP
rs1463856016 204 dbSNP
rs965943841 212 dbSNP
rs955684385 219 dbSNP
rs1209967690 223 dbSNP
rs751565016 225 dbSNP
rs1025605867 240 dbSNP
rs551712963 241 dbSNP
rs994583419 248 dbSNP
rs1361399379 250 dbSNP
rs556893936 253 dbSNP
rs1231926452 266 dbSNP
rs983436174 267 dbSNP
rs76460777 271 dbSNP
rs536888348 272 dbSNP
rs1002050595 273 dbSNP
rs1306131885 286 dbSNP
rs1333773177 293 dbSNP
rs1321121545 295 dbSNP
rs563087100 296 dbSNP
rs1346674656 299 dbSNP
rs1012196258 301 dbSNP
rs543091357 302 dbSNP
rs1056349711 303 dbSNP
rs939041929 321 dbSNP
rs1014468006 322 dbSNP
rs1184405025 325 dbSNP
rs574580001 327 dbSNP
rs1381198944 333 dbSNP
rs1175836270 334 dbSNP
rs1448032193 338 dbSNP
rs752961618 341 dbSNP
rs1389875735 343 dbSNP
rs1042024134 346 dbSNP
rs946392893 348 dbSNP
rs1449196815 351 dbSNP
rs368628690 354 dbSNP
rs1254711020 355 dbSNP
rs1199364481 368 dbSNP
rs1394231919 370 dbSNP
rs1392969504 372 dbSNP
rs914935193 373 dbSNP
rs1369918571 380 dbSNP
rs990347485 383 dbSNP
rs1305096732 389 dbSNP
rs1052071084 396 dbSNP
rs942987925 405 dbSNP
rs1251295862 407 dbSNP
rs934970664 408 dbSNP
rs1201034451 411 dbSNP
rs1239197658 413 dbSNP
rs911388395 422 dbSNP
rs1483312776 425 dbSNP
rs377003248 427 dbSNP
rs1427523854 446 dbSNP
rs955451127 447 dbSNP
rs1169797593 450 dbSNP
rs1371304991 464 dbSNP
rs561101598 466 dbSNP
rs1463489035 473 dbSNP
rs143088973 474 dbSNP
rs963016905 475 dbSNP
rs1016977729 483 dbSNP
rs1367846678 486 dbSNP
rs921753127 491 dbSNP
rs115960150 511 dbSNP
rs944603490 512 dbSNP
rs907811291 514 dbSNP
rs558564985 516 dbSNP
rs1034814806 517 dbSNP
rs1248722428 538 dbSNP
rs1186106954 548 dbSNP
rs980175794 553 dbSNP
rs1003798336 561 dbSNP
rs1417070339 565 dbSNP
rs545466290 569 dbSNP
rs1166615688 570 dbSNP
rs1350216371 572 dbSNP
rs186579200 580 dbSNP
rs532896438 581 dbSNP
rs956221071 582 dbSNP
rs556732323 585 dbSNP
rs946514923 594 dbSNP
rs1168803364 600 dbSNP
rs1279452136 602 dbSNP
rs1000488184 607 dbSNP
rs903513401 608 dbSNP
rs1476621218 609 dbSNP
rs1292504975 614 dbSNP
rs1367201106 620 dbSNP
rs1215344960 623 dbSNP
rs1259113789 624 dbSNP
rs1043792978 627 dbSNP
rs893454363 634 dbSNP
rs1187540985 647 dbSNP
rs1038716046 656 dbSNP
rs1256775448 660 dbSNP
rs1474205331 669 dbSNP
rs942916909 678 dbSNP
rs1258928863 682 dbSNP
rs1202454388 686 dbSNP
rs1414278365 687 dbSNP
rs995901325 688 dbSNP
rs911482060 691 dbSNP
rs900269470 692 dbSNP
rs986900852 694 dbSNP
rs1419832247 695 dbSNP
rs934173708 700 dbSNP
rs1197304690 702 dbSNP
rs1040180621 703 dbSNP
rs1413495608 715 dbSNP
rs989706236 720 dbSNP
rs1282461420 721 dbSNP
rs1305198497 722 dbSNP
rs1356092891 723 dbSNP
rs935743754 724 dbSNP
rs1245353432 725 dbSNP
rs1357293331 726 dbSNP
rs1295160450 728 dbSNP
rs1408100199 731 dbSNP
rs921708221 732 dbSNP
rs1381823852 733 dbSNP
rs1439953014 733 dbSNP
rs1351563420 734 dbSNP
rs1373108130 734 dbSNP
rs1221685437 735 dbSNP
rs1415615542 735 dbSNP
rs182866721 735 dbSNP
rs1241170690 736 dbSNP
rs1350076692 737 dbSNP
rs1329836136 738 dbSNP
rs1411993757 739 dbSNP
rs9905232 740 dbSNP
rs1389093465 741 dbSNP
rs1478756695 741 dbSNP
rs3809890 742 dbSNP
rs1163053150 743 dbSNP
rs1329842107 745 dbSNP
rs1212820777 746 dbSNP
rs1275549438 746 dbSNP
rs1283617510 746 dbSNP
rs1325551712 746 dbSNP
rs1329543363 746 dbSNP
rs1338771878 746 dbSNP
rs1340277521 746 dbSNP
rs1402916912 746 dbSNP
rs1447983454 746 dbSNP
rs71161632 746 dbSNP
rs1462392735 749 dbSNP
rs1250800930 750 dbSNP
rs1452940317 751 dbSNP
rs1420685656 752 dbSNP
rs3809891 755 dbSNP
rs1472003150 756 dbSNP
rs944952428 761 dbSNP
rs907739575 763 dbSNP
rs974773446 766 dbSNP
rs4467132 769 dbSNP
rs1426395754 775 dbSNP
rs973216543 777 dbSNP
rs191950560 778 dbSNP
rs1324381544 794 dbSNP
rs1325933655 802 dbSNP
rs536712433 806 dbSNP
rs908081222 807 dbSNP
rs990825783 807 dbSNP
rs970137110 808 dbSNP
rs959245848 812 dbSNP
rs1034950569 813 dbSNP
rs1210071475 814 dbSNP
rs1283117331 826 dbSNP
rs1444841215 834 dbSNP
rs1003485699 838 dbSNP
rs917307968 842 dbSNP
rs1336794007 848 dbSNP
rs1266213583 849 dbSNP
rs992935490 856 dbSNP
rs966932176 880 dbSNP
rs1384505255 886 dbSNP
rs1226615826 888 dbSNP
rs1300076829 892 dbSNP
rs1417991257 892 dbSNP
rs956190046 895 dbSNP
rs1020819467 903 dbSNP
rs1310411728 906 dbSNP
rs72849537 909 dbSNP
rs1245231537 915 dbSNP
rs36085442 917 dbSNP
rs1038641685 918 dbSNP
rs796228038 921 dbSNP
rs1218290544 922 dbSNP
rs1007193722 925 dbSNP
rs112688604 928 dbSNP
rs1485025061 931 dbSNP
rs1051270491 933 dbSNP
rs1021938907 935 dbSNP
rs996258722 936 dbSNP
rs866974496 937 dbSNP
rs1363476491 939 dbSNP
rs1319923528 949 dbSNP
rs1438097088 951 dbSNP
rs1397291061 952 dbSNP
rs1381009418 955 dbSNP
rs1434180962 956 dbSNP
rs1157679255 959 dbSNP
rs1040510533 963 dbSNP
rs186692593 965 dbSNP
rs1456236628 968 dbSNP
rs1408003541 976 dbSNP
rs1008643067 980 dbSNP
rs886268522 986 dbSNP
rs1272069516 1003 dbSNP
rs918744838 1005 dbSNP
rs1230420993 1006 dbSNP
rs1037242563 1013 dbSNP
rs1245791307 1023 dbSNP
rs941406825 1036 dbSNP
rs571946048 1037 dbSNP
rs920519135 1040 dbSNP
rs1180822951 1044 dbSNP
rs990793199 1045 dbSNP
rs959341857 1046 dbSNP
rs1246106504 1052 dbSNP
rs1044346859 1059 dbSNP
rs551651763 1064 dbSNP
rs767135219 1065 dbSNP
rs1167198741 1077 dbSNP
rs532005126 1116 dbSNP
rs181972805 1120 dbSNP
rs1397853321 1129 dbSNP
rs189313439 1136 dbSNP
rs982428946 1138 dbSNP
rs529766138 1146 dbSNP
rs1369759660 1150 dbSNP
rs1343114102 1151 dbSNP
rs560927741 1152 dbSNP
rs1274529874 1154 dbSNP
rs1010748508 1158 dbSNP
rs564657104 1165 dbSNP
rs957756106 1167 dbSNP
rs1318978599 1179 dbSNP
rs764042397 1180 dbSNP
rs1017326195 1185 dbSNP
rs1257977022 1187 dbSNP
rs1316508530 1190 dbSNP
rs761342164 1191 dbSNP
rs113538857 1213 dbSNP
rs1488296904 1218 dbSNP
rs1189642823 1219 dbSNP
rs148944344 1219 dbSNP
rs1319660647 1220 dbSNP
rs1018601620 1226 dbSNP
rs1192939617 1243 dbSNP
rs1008559780 1252 dbSNP
rs1467034855 1254 dbSNP
rs1171086532 1271 dbSNP
rs1393401981 1275 dbSNP
rs1456082115 1276 dbSNP
rs1294859809 1278 dbSNP
rs998843100 1287 dbSNP
rs763606194 1288 dbSNP
rs1037576552 1305 dbSNP
rs762839350 1316 dbSNP
rs1220961757 1319 dbSNP
rs910072553 1323 dbSNP
rs1055202001 1327 dbSNP
rs1388022887 1329 dbSNP
rs938110998 1349 dbSNP
rs1488880279 1354 dbSNP
rs775116585 1354 dbSNP
rs769819230 1359 dbSNP
rs1260990026 1365 dbSNP
rs1478778270 1371 dbSNP
rs1243828187 1381 dbSNP
rs565206025 1382 dbSNP
rs913833611 1384 dbSNP
rs1421761239 1405 dbSNP
rs989695421 1409 dbSNP
rs1350089288 1424 dbSNP
rs1452484125 1431 dbSNP
rs559501561 1436 dbSNP
rs770895644 1438 dbSNP
rs745801778 1439 dbSNP
rs1378988364 1440 dbSNP
rs1017422309 1452 dbSNP
rs1315163211 1453 dbSNP
rs1057157040 1470 dbSNP
rs985837689 1471 dbSNP
rs145763670 1472 dbSNP
rs1030372632 1482 dbSNP
rs924704049 1483 dbSNP
rs369616607 1492 dbSNP
rs1482182851 1493 dbSNP
rs1228159728 1496 dbSNP
rs978871228 1496 dbSNP
rs993189747 1501 dbSNP
rs897375713 1502 dbSNP
rs1381632482 1505 dbSNP
rs1468647150 1509 dbSNP
rs1419773605 1510 dbSNP
rs1015826176 1530 dbSNP
rs947526106 1550 dbSNP
rs771011496 1551 dbSNP
rs1358126540 1555 dbSNP
rs576522639 1561 dbSNP
rs556571593 1565 dbSNP
rs747039592 1566 dbSNP
rs1446334170 1568 dbSNP
rs1304994088 1578 dbSNP
rs1055339462 1581 dbSNP
rs1436122668 1584 dbSNP
rs1368346020 1588 dbSNP
rs1432111997 1601 dbSNP
rs1167706797 1602 dbSNP
rs1428943937 1607 dbSNP
rs1356026023 1609 dbSNP
rs976064671 1613 dbSNP
rs938037515 1614 dbSNP
rs778085385 1615 dbSNP
rs1018539343 1617 dbSNP
rs1256815182 1623 dbSNP
rs542759328 1627 dbSNP
rs1457101731 1635 dbSNP
rs987108773 1642 dbSNP
rs574040175 1647 dbSNP
rs1486749131 1648 dbSNP
rs1272812716 1657 dbSNP
rs1439822304 1663 dbSNP
rs869172 1666 dbSNP
rs1046801920 1667 dbSNP
rs945415797 1674 dbSNP
rs1275704450 1680 dbSNP
rs1025999609 1681 dbSNP
rs553962488 1682 dbSNP
rs1227044380 1683 dbSNP
rs758513650 1694 dbSNP
rs562343720 1696 dbSNP
rs141350155 1697 dbSNP
rs1293323317 1699 dbSNP
rs147833327 1701 dbSNP
rs1196501648 1715 dbSNP
rs1259635065 1716 dbSNP
rs185229231 1721 dbSNP
rs954431686 1724 dbSNP
rs1348209971 1727 dbSNP
rs1030099498 1730 dbSNP
rs1057126830 1735 dbSNP
rs972245106 1736 dbSNP
rs961722078 1741 dbSNP
rs1193491188 1752 dbSNP
rs1462296217 1757 dbSNP
rs1430589051 1759 dbSNP
rs903209901 1760 dbSNP
rs1162438168 1762 dbSNP
rs1404656523 1767 dbSNP
rs1418518623 1768 dbSNP
rs1402851638 1770 dbSNP
rs779135967 1782 dbSNP
rs538115473 1783 dbSNP
rs1329486418 1785 dbSNP
rs1165722999 1790 dbSNP
rs921401595 1791 dbSNP
rs947531394 1791 dbSNP
rs1279882534 1792 dbSNP
rs1318259741 1798 dbSNP
rs569330343 1801 dbSNP
rs1287293733 1809 dbSNP
rs1249883902 1813 dbSNP
rs754404104 1815 dbSNP
rs1452887811 1817 dbSNP
rs944256079 1820 dbSNP
rs1005803906 1821 dbSNP
rs1477795586 1828 dbSNP
rs1192062999 1842 dbSNP
rs1426240115 1843 dbSNP
rs1475944323 1843 dbSNP
rs549318393 1850 dbSNP
rs1388823126 1866 dbSNP
rs1407191351 1867 dbSNP
rs1303867509 1869 dbSNP
rs527370564 1872 dbSNP
rs1398084347 1873 dbSNP
rs1279936877 1874 dbSNP
rs1326871501 1881 dbSNP
rs1243775158 1889 dbSNP
rs767120626 1889 dbSNP
rs756851457 1894 dbSNP
rs763878643 1898 dbSNP
rs868190365 1912 dbSNP
rs529650209 1915 dbSNP
rs144496104 1919 dbSNP
rs1215169490 1920 dbSNP
rs1265959430 1929 dbSNP
rs1187247037 1931 dbSNP
rs1447988932 1931 dbSNP
rs945481761 1940 dbSNP
rs762808809 1941 dbSNP
rs763848756 1946 dbSNP
rs1164387610 1950 dbSNP
rs892459880 1954 dbSNP
rs1417927811 1959 dbSNP
rs1300020936 1965 dbSNP
rs1326543141 1970 dbSNP
rs1062704 1971 dbSNP
rs879221430 1971 dbSNP
rs571240068 1979 dbSNP
rs139665208 1984 dbSNP
rs936555059 1989 dbSNP
rs1391541853 1990 dbSNP
rs556667035 2004 dbSNP
rs1341985263 2007 dbSNP
rs551040753 2016 dbSNP
rs374801170 2017 dbSNP
rs180874642 2019 dbSNP
rs1395084703 2026 dbSNP
rs923124096 2033 dbSNP
rs1263060329 2034 dbSNP
rs188981011 2058 dbSNP
rs1200333064 2067 dbSNP
rs962141577 2076 dbSNP
rs1254521484 2079 dbSNP
rs1463065659 2084 dbSNP
rs150929572 2085 dbSNP
rs984462636 2087 dbSNP
rs1237786743 2091 dbSNP
rs952912087 2092 dbSNP
rs142516661 2097 dbSNP
rs1002480949 2104 dbSNP
rs1410462302 2106 dbSNP
rs1043072074 2107 dbSNP
rs1170675118 2119 dbSNP
rs1404169060 2120 dbSNP
rs1470116925 2129 dbSNP
rs970908273 2139 dbSNP
rs1012038876 2147 dbSNP
rs1448484286 2148 dbSNP
rs899924554 2165 dbSNP
rs776570768 2169 dbSNP
rs944190685 2184 dbSNP
rs573946597 2185 dbSNP
rs769995007 2186 dbSNP
rs148421104 2199 dbSNP
rs370636811 2200 dbSNP
rs1047294147 2205 dbSNP
rs1053682477 2211 dbSNP
rs918883975 2215 dbSNP
rs1179111960 2216 dbSNP
rs1259589677 2219 dbSNP
rs1432667050 2233 dbSNP
rs1196747351 2234 dbSNP
rs1000838480 2235 dbSNP
rs146216849 2236 dbSNP
rs1298793739 2237 dbSNP
rs973105879 2240 dbSNP
rs760845569 2251 dbSNP
rs774179057 2254 dbSNP
rs1389465620 2257 dbSNP
rs1050289801 2259 dbSNP
rs141673049 2260 dbSNP
rs915644678 2263 dbSNP
rs1277980675 2270 dbSNP
rs531330737 2282 dbSNP
rs991674999 2286 dbSNP
rs773138627 2289 dbSNP
rs1252096217 2296 dbSNP
rs3809892 2298 dbSNP
rs772392351 2312 dbSNP
rs1035559603 2314 dbSNP
rs998731289 2323 dbSNP
rs1480737143 2324 dbSNP
rs1192776515 2326 dbSNP
rs908974408 2327 dbSNP
rs984433583 2328 dbSNP
rs958343118 2341 dbSNP
rs926975854 2345 dbSNP
rs981038967 2354 dbSNP
rs575491308 2358 dbSNP
rs1011560959 2359 dbSNP
rs555531992 2359 dbSNP
rs1491041762 2360 dbSNP
rs557604098 2360 dbSNP
rs899862225 2360 dbSNP
rs1454415472 2361 dbSNP
rs555639132 2361 dbSNP
rs1347179771 2362 dbSNP
rs184967828 2363 dbSNP
rs764001482 2371 dbSNP
rs1296615861 2386 dbSNP
rs891255744 2390 dbSNP
rs1242822869 2393 dbSNP
rs971428533 2401 dbSNP
rs1025105211 2405 dbSNP
rs1195928968 2406 dbSNP
rs1215884879 2410 dbSNP
rs1047228448 2413 dbSNP
rs1010159299 2415 dbSNP
rs1205176332 2416 dbSNP
rs1486599280 2417 dbSNP
rs1421708189 2422 dbSNP
rs1325528089 2426 dbSNP
rs1165016721 2435 dbSNP
rs748541420 2449 dbSNP
rs1253869795 2467 dbSNP
rs956786885 2471 dbSNP
rs192574865 2474 dbSNP
rs547485450 2475 dbSNP
rs920207891 2485 dbSNP
rs1359157650 2492 dbSNP
rs1433460448 2499 dbSNP
rs748318060 2504 dbSNP
rs559495059 2505 dbSNP
rs779128097 2518 dbSNP
rs889106175 2520 dbSNP
rs1239483851 2521 dbSNP
rs1283847280 2524 dbSNP
rs915594569 2529 dbSNP
rs1216347924 2534 dbSNP
rs991233211 2537 dbSNP
rs1050423682 2543 dbSNP
rs76936014 2550 dbSNP
rs1482152000 2560 dbSNP
rs146136964 2567 dbSNP
rs14526 2568 dbSNP
rs1296253490 2572 dbSNP
rs1438583857 2573 dbSNP
rs546230456 2582 dbSNP
rs1387162850 2583 dbSNP
rs149637701 2583 dbSNP
rs1160383197 2588 dbSNP
rs1359012991 2593 dbSNP
rs1468549104 2594 dbSNP
rs1036168680 2597 dbSNP
rs1021531235 2602 dbSNP
rs138332813 2614 dbSNP
rs531527755 2615 dbSNP
rs1434302269 2617 dbSNP
rs562678952 2621 dbSNP
rs780739152 2630 dbSNP
rs1018695555 2631 dbSNP
rs937108210 2645 dbSNP
rs111757117 2651 dbSNP
rs1460825579 2652 dbSNP
rs891224442 2655 dbSNP
rs542495900 2656 dbSNP
rs1234122787 2660 dbSNP
rs981519799 2661 dbSNP
rs1425050265 2668 dbSNP
rs1479681981 2673 dbSNP
rs1179070106 2675 dbSNP
rs1025744310 2679 dbSNP
rs949629340 2684 dbSNP
rs918179533 2691 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HepG2 , Hep3B , Huh-7 , SNU398 , SNU449 , SNU182 , SNU475
Disease MIMAT0002832
Location of target site 3'UTR
Tools used in this research EMBL , miRanda , TargetScan
Original Description (Extracted from the article) ... "we investigated the regulation of PTEN ...

- Fornari F; Milazzo M; Chieco P; Negrini M; et al., 2012, The Journal of pathology.

Article - Fornari F; Milazzo M; Chieco P; Negrini M; et al.
- The Journal of pathology, 2012
MiR-519d belongs to the chromosome 19 miRNA cluster (C19MC), the largest human miRNA cluster. One of its members, miR-519d, is over-expressed in hepatocellular carcinoma (HCC) and we characterized its contribution to hepatocarcinogenesis. In HCC cells, the over-expression of miR-519d promotes cell proliferation, invasion and impairs apoptosis following anticancer treatments. These functions are, at least in part, exerted through the direct targeting of CDKN1A/p21, PTEN, AKT3 and TIMP2. The mechanisms underlying miR-519d aberrant expression in HCC were assayed by genomic DNA amplification, methylation analysis and ChIP assay. The aberrant hypomethylation of C19MC and TP53 were respectively identified as an epigenetic change allowing the aberrant expression of miR-519d and one of the factors able to activate its transcription. In conclusion, we assessed the oncogenic role of miR-519d in HCC by characterizing its biological functions, including the modulation of response to anticancer treatments and by identifying CDKN1A/p21, PTEN, AKT3 and TIMP2 among its targets.
LinkOut: [PMID: 22262409]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.627 1.1e-2 0.659 7.1e-3 13 Click to see details
GSE42095 Differentiated embryonic stem cells -0.452 1.5e-2 -0.667 2.5e-4 23 Click to see details
GSE28544 Breast cancer -0.428 1.8e-2 -0.424 1.9e-2 24 Click to see details
GSE26953 Aortic valvular endothelial cells 0.369 3.8e-2 0.311 7.0e-2 24 Click to see details
GSE38226 Liver fibrosis -0.285 1.1e-1 0.352 5.9e-2 21 Click to see details
GSE32688 Pancreatic cancer 0.223 1.1e-1 0.227 1.1e-1 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.221 1.4e-1 -0.298 7.4e-2 25 Click to see details
GSE27834 Pluripotent stem cells -0.209 2.2e-1 -0.482 2.9e-2 16 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.159 2.2e-1 0.303 7.0e-2 25 Click to see details
GSE14794 Lymphoblastoid cells 0.076 2.4e-1 0.002 4.9e-1 90 Click to see details
GSE17306 Multiple myeloma -0.084 2.8e-1 0.433 9.4e-4 49 Click to see details
GSE17498 Multiple myeloma 0.086 3.0e-1 0.173 1.4e-1 40 Click to see details
GSE21687 Ependynoma primary tumors -0.067 3.0e-1 -0.080 2.6e-1 64 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.193 3.2e-1 -0.286 2.5e-1 8 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.067 3.9e-1 0.424 3.1e-2 20 Click to see details
GSE21849 B cell lymphoma 0.021 4.6e-1 0.311 5.0e-2 29 Click to see details
GSE19350 CNS germ cell tumors -0.03 4.6e-1 -0.110 3.7e-1 12 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LIHC -0.84 0.08 -1.000 0.5 4 Click to see details
HNSC -0.928 0.12 -0.500 0.33 3 Click to see details
BRCA -0.319 0.3 0.200 0.37 5 Click to see details
BRCA -0.319 0.3 0.200 0.37 5 Click to see details
BRCA -0.319 0.3 0.200 0.37 5 Click to see details
BRCA -0.319 0.3 0.200 0.37 5 Click to see details
325 hsa-miR-519c-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000496 HIF1A hypoxia inducible factor 1 alpha subunit 4 1
MIRT000998 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 4 3
MIRT003732 ELAVL1 ELAV like RNA binding protein 1 3 1
MIRT006639 TIMP2 TIMP metallopeptidase inhibitor 2 3 1
MIRT006640 PTEN phosphatase and tensin homolog 3 1
MIRT006641 CDKN1A cyclin dependent kinase inhibitor 1A 3 1
MIRT055028 TPRG1L tumor protein p63 regulated 1 like 2 2
MIRT055393 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT056828 REEP3 receptor accessory protein 3 2 2
MIRT060504 PPP6R3 protein phosphatase 6 regulatory subunit 3 2 2
MIRT061796 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 10
MIRT063354 ETNK1 ethanolamine kinase 1 2 2
MIRT064424 ARID4B AT-rich interaction domain 4B 2 2
MIRT064719 CCND2 cyclin D2 2 2
MIRT064805 ZBTB18 zinc finger and BTB domain containing 18 2 4
MIRT065609 DAZAP2 DAZ associated protein 2 2 10
MIRT065622 CLIC4 chloride intracellular channel 4 2 4
MIRT065872 GDF11 growth differentiation factor 11 2 2
MIRT065892 RAB5B RAB5B, member RAS oncogene family 2 8
MIRT068751 RB1 RB transcriptional corepressor 1 2 2
MIRT070050 FANCM Fanconi anemia complementation group M 2 2
MIRT071004 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT071334 CMPK1 cytidine/uridine monophosphate kinase 1 2 6
MIRT071912 ZFYVE9 zinc finger FYVE-type containing 9 2 2
MIRT072732 GLCE glucuronic acid epimerase 2 2
MIRT076028 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 6
MIRT076046 PITPNA phosphatidylinositol transfer protein alpha 2 2
MIRT079353 CCDC137 coiled-coil domain containing 137 2 2
MIRT080227 SMAD4 SMAD family member 4 2 6
MIRT081122 LDLR low density lipoprotein receptor 2 8
MIRT081205 MIDN midnolin 2 10
MIRT085098 IFNAR2 interferon alpha and beta receptor subunit 2 2 6
MIRT085149 SLC5A3 solute carrier family 5 member 3 2 4
MIRT086436 NABP1 nucleic acid binding protein 1 2 6
MIRT088037 UBXN2A UBX domain protein 2A 2 2
MIRT088132 SEPT2 septin 2 2 4
MIRT088343 MAPRE3 microtubule associated protein RP/EB family member 3 2 8
MIRT090645 U2SURP U2 snRNP associated SURP domain containing 2 6
MIRT090805 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT091692 TGFBR2 transforming growth factor beta receptor 2 2 4
MIRT092689 C3ORF38 chromosome 3 open reading frame 38 2 8
MIRT093954 SLAIN2 SLAIN motif family member 2 2 2
MIRT095727 ANKH ANKH inorganic pyrophosphate transport regulator 2 8
MIRT097158 FCHO2 FCH domain only 2 2 2
MIRT099319 QKI QKI, KH domain containing RNA binding 2 4
MIRT099835 SOX4 SRY-box 4 2 10
MIRT100773 ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2 2
MIRT100955 CENPQ centromere protein Q 2 4
MIRT102229 HBP1 HMG-box transcription factor 1 2 2
MIRT102299 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT102621 UBN2 ubinuclein 2 2 8
MIRT103780 PURB purine rich element binding protein B 2 2
MIRT104168 PHTF2 putative homeodomain transcription factor 2 2 6
MIRT107279 FAM73B mitoguardin 2 2 2
MIRT107945 TMEM2 transmembrane protein 2 2 2
MIRT108265 HABP4 hyaluronan binding protein 4 2 2
MIRT124812 BICD2 BICD cargo adaptor 2 2 2
MIRT138707 MPP5 membrane palmitoylated protein 5 2 2
MIRT139880 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT144312 NFAT5 nuclear factor of activated T-cells 5 2 8
MIRT145605 LASP1 LIM and SH3 protein 1 2 2
MIRT153350 MAVS mitochondrial antiviral signaling protein 2 4
MIRT153986 PRNP prion protein 2 2
MIRT159129 NRBP1 nuclear receptor binding protein 1 2 2
MIRT164533 MSMO1 methylsterol monooxygenase 1 2 2
MIRT165912 CREBRF CREB3 regulatory factor 2 2
MIRT170858 TAX1BP1 Tax1 binding protein 1 2 4
MIRT172157 FZD6 frizzled class receptor 6 2 8
MIRT173701 PRPF4 pre-mRNA processing factor 4 2 2
MIRT175003 ZBTB5 zinc finger and BTB domain containing 5 2 4
MIRT175400 ACSL4 acyl-CoA synthetase long chain family member 4 2 2
MIRT178069 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT178675 FAM102B family with sequence similarity 102 member B 2 2
MIRT180847 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 4
MIRT194911 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT195755 ATMIN ATM interactor 2 6
MIRT196623 TAOK1 TAO kinase 1 2 6
MIRT205286 STK11IP serine/threonine kinase 11 interacting protein 2 2
MIRT206051 PPARA peroxisome proliferator activated receptor alpha 2 2
MIRT206198 RAB10 RAB10, member RAS oncogene family 2 4
MIRT208980 SKIL SKI like proto-oncogene 2 10
MIRT223637 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT224757 DPYSL2 dihydropyrimidinase like 2 2 2
MIRT227995 NFIB nuclear factor I B 2 4
MIRT230973 PRRG4 proline rich and Gla domain 4 2 2
MIRT238183 ANKRD33B ankyrin repeat domain 33B 2 10
MIRT242425 HAS3 hyaluronan synthase 3 2 2
MIRT242666 SALL3 spalt like transcription factor 3 2 4
MIRT242765 FNBP1L formin binding protein 1 like 2 6
MIRT243095 LCLAT1 lysocardiolipin acyltransferase 1 2 4
MIRT243437 PAK2 p21 (RAC1) activated kinase 2 2 2
MIRT243964 MAP1B microtubule associated protein 1B 2 2
MIRT244776 RABGAP1 RAB GTPase activating protein 1 2 2
MIRT246630 TMEM109 transmembrane protein 109 2 2
MIRT246968 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT266055 FJX1 four jointed box 1 2 4
MIRT266858 SLC25A44 solute carrier family 25 member 44 2 2
MIRT283184 C16ORF52 chromosome 16 open reading frame 52 2 2
MIRT286955 SOCS7 suppressor of cytokine signaling 7 2 2
MIRT293651 PVR poliovirus receptor 2 4
MIRT295178 ZNF317 zinc finger protein 317 2 4
MIRT302453 CLIP4 CAP-Gly domain containing linker protein family member 4 2 2
MIRT303499 NAGK N-acetylglucosamine kinase 2 6
MIRT368755 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT383207 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT383610 POU2F1 POU class 2 homeobox 1 2 2
MIRT396102 CASP2 caspase 2 2 2
MIRT441419 FAM9C family with sequence similarity 9 member C 2 2
MIRT446818 C5orf30 chromosome 5 open reading frame 30 2 2
MIRT448307 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT461781 MPDU1 mannose-P-dolichol utilization defect 1 2 2
MIRT462816 NTN1 netrin 1 2 2
MIRT463613 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT464560 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT464842 RPS27A ribosomal protein S27a 2 12
MIRT465225 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT466446 TFAM transcription factor A, mitochondrial 2 8
MIRT466836 STX6 syntaxin 6 2 6
MIRT467185 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468179 SGMS1 sphingomyelin synthase 1 2 2
MIRT469850 PXK PX domain containing serine/threonine kinase like 2 8
MIRT471612 PAQR5 progestin and adipoQ receptor family member 5 2 19
MIRT472008 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT472159 NIN ninein 2 4
MIRT472336 NETO2 neuropilin and tolloid like 2 2 4
MIRT473162 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT473623 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT473682 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT473805 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT474416 KLHL28 kelch like family member 28 2 8
MIRT474736 KIF13A kinesin family member 13A 2 6
MIRT474966 KCTD10 potassium channel tetramerization domain containing 10 2 4
MIRT475464 HSPA8 heat shock protein family A (Hsp70) member 8 2 6
MIRT476120 GPR157 G protein-coupled receptor 157 2 2
MIRT476203 GNS glucosamine (N-acetyl)-6-sulfatase 2 6
MIRT477180 F3 coagulation factor III, tissue factor 2 8
MIRT478103 DLG5 discs large MAGUK scaffold protein 5 2 6
MIRT478713 CSNK1A1 casein kinase 1 alpha 1 2 6
MIRT479055 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 8
MIRT480008 CAPRIN2 caprin family member 2 2 4
MIRT480519 C11orf30 EMSY, BRCA2 interacting transcriptional repressor 2 10
MIRT480822 BLCAP bladder cancer associated protein 2 10
MIRT480944 BBX BBX, HMG-box containing 2 8
MIRT481336 ATL3 atlastin GTPase 3 2 2
MIRT481598 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT481877 ANKRD50 ankyrin repeat domain 50 2 2
MIRT482471 ADAR adenosine deaminase, RNA specific 2 4
MIRT484875 ZNF652 zinc finger protein 652 2 2
MIRT485090 SLC30A1 solute carrier family 30 member 1 2 4
MIRT485579 FOXQ1 forkhead box Q1 2 2
MIRT485618 FBXL5 F-box and leucine rich repeat protein 5 2 10
MIRT486751 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT489599 ZDHHC20 zinc finger DHHC-type containing 20 2 10
MIRT489889 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT491654 PDRG1 p53 and DNA damage regulated 1 2 10
MIRT492038 TSG101 tumor susceptibility 101 2 4
MIRT492361 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT492776 PDGFB platelet derived growth factor subunit B 2 2
MIRT493336 LAPTM4A lysosomal protein transmembrane 4 alpha 2 12
MIRT493611 HMGB3 high mobility group box 3 2 6
MIRT497468 DDR2 discoidin domain receptor tyrosine kinase 2 2 2
MIRT498059 SNX5 sorting nexin 5 2 6
MIRT499901 KIAA1191 KIAA1191 2 4
MIRT500489 ZBTB4 zinc finger and BTB domain containing 4 2 6
MIRT500685 TRIM37 tripartite motif containing 37 2 2
MIRT500760 TMEM127 transmembrane protein 127 2 6
MIRT501456 PTPN4 protein tyrosine phosphatase, non-receptor type 4 2 8
MIRT501559 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501983 MAPK1 mitogen-activated protein kinase 1 2 10
MIRT502000 MAP7 microtubule associated protein 7 2 8
MIRT502049 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 6
MIRT502423 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT503044 CAMSAP2 calmodulin regulated spectrin associated protein family member 2 2 2
MIRT503821 TMEM242 transmembrane protein 242 2 4
MIRT504290 PARP1 poly(ADP-ribose) polymerase 1 2 6
MIRT504560 ZNF417 zinc finger protein 417 2 6
MIRT505054 ZNF202 zinc finger protein 202 2 6
MIRT505486 SRSF2 serine and arginine rich splicing factor 2 2 4
MIRT505836 POLR1B RNA polymerase I subunit B 2 4
MIRT506372 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT506451 NACC2 NACC family member 2 2 4
MIRT506673 LZIC leucine zipper and CTNNBIP1 domain containing 2 4
MIRT506834 KIF23 kinesin family member 23 2 4
MIRT506880 KIAA0101 PCNA clamp associated factor 2 6
MIRT507359 FAM129A family with sequence similarity 129 member A 2 6
MIRT507957 BNIP2 BCL2 interacting protein 2 2 6
MIRT509433 MCM7 minichromosome maintenance complex component 7 2 6
MIRT510872 RAN RAN, member RAS oncogene family 2 8
MIRT511078 NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 2 4
MIRT511254 KLHL36 kelch like family member 36 2 6
MIRT513699 RBM20 RNA binding motif protein 20 2 4
MIRT513742 PKNOX1 PBX/knotted 1 homeobox 1 2 2
MIRT513981 CEP97 centrosomal protein 97 2 2
MIRT514092 EPS15L1 epidermal growth factor receptor pathway substrate 15 like 1 2 6
MIRT515928 MFAP2 microfibril associated protein 2 2 4
MIRT519574 ZNFX1 zinc finger NFX1-type containing 1 2 4
MIRT521297 RRAGD Ras related GTP binding D 2 4
MIRT521348 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT521693 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 8
MIRT521778 PPIG peptidylprolyl isomerase G 2 8
MIRT522191 NR2C2 nuclear receptor subfamily 2 group C member 2 2 6
MIRT524696 BTG3 BTG anti-proliferation factor 3 2 8
MIRT525663 NHSL2 NHS like 2 2 2
MIRT527252 TMEM196 transmembrane protein 196 2 2
MIRT527466 CLEC12B C-type lectin domain family 12 member B 2 2
MIRT529535 ICMT isoprenylcysteine carboxyl methyltransferase 2 2
MIRT530146 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2 2
MIRT530851 RAG1 recombination activating 1 2 4
MIRT531109 PEX13 peroxisomal biogenesis factor 13 2 2
MIRT534263 SLC12A7 solute carrier family 12 member 7 2 2
MIRT534756 RASGEF1A RasGEF domain family member 1A 2 2
MIRT535175 PLEKHB2 pleckstrin homology domain containing B2 2 2
MIRT535246 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 4
MIRT535401 PER1 period circadian clock 1 2 2
MIRT536036 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT536347 LEFTY1 left-right determination factor 1 2 2
MIRT536413 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT536437 KMT2B lysine methyltransferase 2B 2 6
MIRT536604 IRF2 interferon regulatory factor 2 2 2
MIRT536642 INO80D INO80 complex subunit D 2 2
MIRT536860 HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2 2
MIRT537241 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2 2
MIRT537728 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT537988 DPP8 dipeptidyl peptidase 8 2 2
MIRT538037 DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 2 2
MIRT538255 CUL3 cullin 3 2 4
MIRT538525 CLCN3 chloride voltage-gated channel 3 2 2
MIRT538659 CCSAP centriole, cilia and spindle associated protein 2 2
MIRT538779 C7orf60 base methyltransferase of 25S rRNA 2 homolog 2 4
MIRT538849 BTG1 BTG anti-proliferation factor 1 2 2
MIRT538923 BRI3BP BRI3 binding protein 2 6
MIRT539114 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT539454 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT541085 RLIM ring finger protein, LIM domain interacting 2 2
MIRT543117 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT543181 FICD FIC domain containing 2 2
MIRT543575 RPF2 ribosome production factor 2 homolog 2 4
MIRT544113 IPMK inositol polyphosphate multikinase 2 2
MIRT544625 CSDE1 cold shock domain containing E1 2 2
MIRT544699 ZNF224 zinc finger protein 224 2 4
MIRT544992 MFF mitochondrial fission factor 2 4
MIRT546248 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT546282 TMEM30A transmembrane protein 30A 2 4
MIRT546290 TMEM200C transmembrane protein 200C 2 4
MIRT546558 SATB2 SATB homeobox 2 2 2
MIRT546815 RAP2C RAP2C, member of RAS oncogene family 2 2
MIRT547046 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT547474 MBNL3 muscleblind like splicing regulator 3 2 4
MIRT547761 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT547892 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT548315 EPHA4 EPH receptor A4 2 2
MIRT548383 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 4
MIRT548460 EGLN3 egl-9 family hypoxia inducible factor 3 2 2
MIRT548579 DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 2 2
MIRT548858 CERCAM cerebral endothelial cell adhesion molecule 2 2
MIRT548896 CHEK2 checkpoint kinase 2 2 4
MIRT549319 ARHGAP12 Rho GTPase activating protein 12 2 4
MIRT550302 ZNF681 zinc finger protein 681 2 2
MIRT551120 ZNF107 zinc finger protein 107 2 2
MIRT551406 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT552173 DAD1 defender against cell death 1 2 2
MIRT552856 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT552892 WASL Wiskott-Aldrich syndrome like 2 4
MIRT553075 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT553668 TFAP4 transcription factor AP-4 2 4
MIRT553700 TCF7L2 transcription factor 7 like 2 2 2
MIRT554608 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT554860 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT556157 MECP2 methyl-CpG binding protein 2 2 2
MIRT556179 MCC mutated in colorectal cancers 2 2
MIRT556529 LIN52 lin-52 DREAM MuvB core complex component 2 2
MIRT556723 KLHL21 kelch like family member 21 2 4
MIRT557054 HOXB3 homeobox B3 2 2
MIRT557587 GNPTAB N-acetylglucosamine-1-phosphate transferase alpha and beta subunits 2 2
MIRT557661 GATA6 GATA binding protein 6 2 2
MIRT557753 FRS2 fibroblast growth factor receptor substrate 2 2 2
MIRT557881 FEM1B fem-1 homolog B 2 4
MIRT558215 EFCAB14 EF-hand calcium binding domain 14 2 4
MIRT558264 DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 2 2
MIRT558327 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT558766 CFL2 cofilin 2 2 2
MIRT561037 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT561324 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT561641 RUNX3 runt related transcription factor 3 2 2
MIRT562555 CCDC71L coiled-coil domain containing 71 like 2 4
MIRT562961 LRPAP1 LDL receptor related protein associated protein 1 2 2
MIRT564680 ZNF35 zinc finger protein 35 2 2
MIRT565694 SESN3 sestrin 3 2 2
MIRT565910 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT566141 RACGAP1 Rac GTPase activating protein 1 2 2
MIRT567047 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT567076 KBTBD2 kelch repeat and BTB domain containing 2 2 2
MIRT567539 FGFR1OP FGFR1 oncogene partner 2 2
MIRT567624 FAM210A family with sequence similarity 210 member A 2 2
MIRT570321 ZNF70 zinc finger protein 70 2 2
MIRT571759 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT571857 NKIRAS1 NFKB inhibitor interacting Ras like 1 2 2
MIRT573372 LIMA1 LIM domain and actin binding 1 2 2
MIRT574561 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT614729 ATAT1 alpha tubulin acetyltransferase 1 2 4
MIRT617877 ESR1 estrogen receptor 1 2 2
MIRT624421 CBX8 chromobox 8 2 2
MIRT625865 SLC35C2 solute carrier family 35 member C2 2 2
MIRT630703 DICER1 dicer 1, ribonuclease III 2 4
MIRT632514 PTPN9 protein tyrosine phosphatase, non-receptor type 9 2 2
MIRT641797 USP32 ubiquitin specific peptidase 32 2 2
MIRT663625 SEC23B Sec23 homolog B, coat complex II component 2 2
MIRT680135 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT702388 KLF10 Kruppel like factor 10 2 2
MIRT707830 TMEM133 transmembrane protein 133 2 2
MIRT708885 MOCS2 molybdenum cofactor synthesis 2 2 2
MIRT709122 C3orf18 chromosome 3 open reading frame 18 2 2
MIRT709635 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT710596 CDCA4 cell division cycle associated 4 2 2
MIRT710802 IFNLR1 interferon lambda receptor 1 2 2
MIRT711782 RFXAP regulatory factor X associated protein 2 2
MIRT713344 KLRD1 killer cell lectin like receptor D1 2 2
MIRT713640 MED8 mediator complex subunit 8 2 2
MIRT713916 IGF2R insulin like growth factor 2 receptor 2 2
MIRT715068 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715206 FKTN fukutin 2 2
MIRT717819 FAM114A1 family with sequence similarity 114 member A1 2 2
MIRT720543 CHERP calcium homeostasis endoplasmic reticulum protein 2 2
MIRT720636 ELF5 E74 like ETS transcription factor 5 2 2
MIRT721703 ISY1 ISY1 splicing factor homolog 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-519c Bilobalide NULL 73581 Quantitative real-time PCR Human breast cancer MCF-7 cells 21796641 2011 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-519c Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-519c-3p Mitoxantrone 4212 NSC279836 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-519c-3p Cisplatin 5460033 NSC119875 approved resistant High Germ Cell Tumor cell line (NTERA-2)
hsa-miR-519c-3p Vinorelbine 44424639 approved resistant High Non-Small Cell Lung Cancer cell line (H358, H1993)
hsa-miR-519c-3p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-519c-3p Gemcitabine 60750 NSC613327 approved sensitive Low Pancreatic Cancer cell line (MIA-PaCa-2)
hsa-miR-519c-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-519c-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-519c-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-519c-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-519c-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-519c-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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