miRTarBase - #MIRT006641


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pre-miRNA Information
pre-miRNA hsa-mir-519c   
Genomic Coordinates chr19: 53686469 - 53686555
Description Homo sapiens miR-519c stem-loop
Comment The 5' arm of this precursor expresses a product related to miR-526 (previously named miR-526c here). Landgraf et al. confirm mature miRNA expression from both arms of the precursor .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-519c-3p
Sequence 54| AAAGUGCAUCUUUUUAGAGGAU |75
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 19 + 53686523 29233923 MiREDiBase
A-to-I 3 19 + 53686524 29233923 MiREDiBase
A-to-I 8 19 + 53686529 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1164669230 4 dbSNP
rs764425172 8 dbSNP
rs1377433094 10 dbSNP
rs751997873 19 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CDKN1A   
Synonyms CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
Description cyclin dependent kinase inhibitor 1A
Transcript NM_000389   
Other Transcripts NM_078467   
Expression
Putative miRNA Targets on CDKN1A
3'UTR of CDKN1A
(miRNA target sites are highlighted)		 
>CDKN1A|NM_000389|3'UTR
   1 TCCGCCCACAGGAAGCCTGCAGTCCTGGAAGCGCGAGGGCCTCAAAGGCCCGCTCTACATCTTCTGCCTTAGTCTCAGTT
  81 TGTGTGTCTTAATTATTATTTGTGTTTTAATTTAAACACCTCCTCATGTACATACCCTGGCCGCCCCCTGCCCCCCAGCC
 161 TCTGGCATTAGAATTATTTAAACAAAAACTAGGCGGTTGAATGAGAGGTTCCTAAGAGTGCTGGGCATTTTTATTTTATG
 241 AAATACTATTTAAAGCCTCCTCATCCCGTGTTCTCCTTTTCCTCTCTCCCGGAGGTTGGGTGGGCCGGCTTCATGCCAGC
 321 TACTTCCTCCTCCCCACTTGTCCGCTGGGTGGTACCCTCTGGAGGGGTGTGGCTCCTTCCCATCGCTGTCACAGGCGGTT
 401 ATGAAATTCACCCCCTTTCCTGGACACTCAGACCTGAATTCTTTTTCATTTGAGAAGTAAACAGATGGCACTTTGAAGGG
 481 GCCTCACCGAGTGGGGGCATCATCAAAAACTTTGGAGTCCCCTCACCTCCTCTAAGGTTGGGCAGGGTGACCCTGAAGTG
 561 AGCACAGCCTAGGGCTGAGCTGGGGACCTGGTACCCTCCTGGCTCTTGATACCCCCCTCTGTCTTGTGAAGGCAGGGGGA
 641 AGGTGGGGTCCTGGAGCAGACCACCCCGCCTGCCCTCATGGCCCCTCTGACCTGCACTGGGGAGCCCGTCTCAGTGTTGA
 721 GCCTTTTCCCTCTTTGGCTCCCCTGTACCTTTTGAGGAGCCCCAGCTACCCTTCTTCTCCAGCTGGGCTCTGCAATTCCC
 801 CTCTGCTGCTGTCCCTCCCCCTTGTCCTTTCCCTTCAGTACCCTCTCAGCTCCAGGTGGCTCTGAGGTGCCTGTCCCACC
 881 CCCACCCCCAGCTCAATGGACTGGAAGGGGAAGGGACACACAAGAAGAAGGGCACCCTAGTTCTACCTCAGGCAGCTCAA
 961 GCAGCGACCGCCCCCTCCTCTAGCTGTGGGGGTGAGGGTCCCATGTGGTGGCACAGGCCCCCTTGAGTGGGGTTATCTCT
1041 GTGTTAGGGGTATATGATGGGGGAGTAGATCTTTCTAGGAGGGAGACACTGGCCCCTCAAATCGTCCAGCGACCTTCCTC
1121 ATCCACCCCATCCCTCCCCAGTTCATTGCACTTTGATTAGCAGCGGAACAAGGAGTCAGACATTTTAAGATGGTGGCAGT
1201 AGAGGCTATGGACAGGGCATGCCACGTGGGCTCATATGGGGCTGGGAGTAGTTGTCTTTCCTGGCACTAACGTTGAGCCC
1281 CTGGAGGCACTGAAGTGCTTAGTGTACTTGGAGTATTGGGGTCTGACCCCAAACACCTTCCAGCTCCTGTAACATACTGG
1361 CCTGGACTGTTTTCTCTCGGCTCCCCATGTGTCCTGGTTCCCGTTTCTCCACCTAGACTGTAAACCTCTCGAGGGCAGGG
1441 ACCACACCCTGTACTGTTCTGTGTCTTTCACAGCTCCTCCCACAATGCTGAATATACAGCAGGTGCTCAATAAATGATTC
1521 TTAGTGACTTTACTTGTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaggagAUUUUUCUA-CGUGAAa 5'
                |||| |||| |||||| 
Target 5' gagaagTAAACAGATGGCACTTt 3'
 452 - 474 140.00 -11.20
2 
miRNA  3' uaggagauuuuucuACGUGAAa 5'
                        ||||||| 
Target 5' cctccccagttcatTGCACTTt 3'
 1133 - 1154 140.00 -11.27
3 
miRNA  3' uagGAGAUUUUUC----UACGUGAAa 5'
             | ||:||: |    :||:|||| 
Target 5' aggCACTGAAGTGCTTAGTGTACTTg 3'
 1285 - 1310 137.00 -11.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN8871647 4 COSMIC
COSN30107428 13 COSMIC
COSN17136499 21 COSMIC
COSN24388178 36 COSMIC
COSN30512604 38 COSMIC
COSN26970192 40 COSMIC
COSN30166588 65 COSMIC
COSN24301745 80 COSMIC
COSN30488608 90 COSMIC
COSN30469357 137 COSMIC
COSN30533369 148 COSMIC
COSN32056942 195 COSMIC
COSN17181950 363 COSMIC
COSN21122568 516 COSMIC
COSN8514252 516 COSMIC
COSN20590362 520 COSMIC
COSN26644634 575 COSMIC
COSN32057748 625 COSMIC
COSN31576773 708 COSMIC
COSN15779126 787 COSMIC
COSN28791109 848 COSMIC
COSN8514253 848 COSMIC
COSN26566755 989 COSMIC
COSN31541982 1111 COSMIC
COSN31595516 1138 COSMIC
COSN9781735 1206 COSMIC
COSN21510222 1432 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs139304346 4 dbSNP
rs747014318 5 dbSNP
rs1184573689 9 dbSNP
rs1396765368 11 dbSNP
rs1445659229 11 dbSNP
rs777207887 12 dbSNP
rs1376040331 15 dbSNP
rs1226999329 17 dbSNP
rs1059234 21 dbSNP
rs770267002 22 dbSNP
rs775069456 23 dbSNP
rs945802868 24 dbSNP
rs1475096701 28 dbSNP
rs762632530 29 dbSNP
rs201408395 32 dbSNP
rs375173291 33 dbSNP
rs41272170 34 dbSNP
rs1482370511 35 dbSNP
rs150869821 36 dbSNP
rs3176357 39 dbSNP
rs754567385 40 dbSNP
rs1166992411 41 dbSNP
rs755968076 44 dbSNP
rs1423988118 48 dbSNP
rs111926164 52 dbSNP
rs575815855 53 dbSNP
rs998171288 56 dbSNP
rs1028124783 57 dbSNP
rs952159534 59 dbSNP
rs983400213 67 dbSNP
rs907923458 69 dbSNP
rs760541872 75 dbSNP
rs1428687704 80 dbSNP
rs976707693 105 dbSNP
rs1451995360 114 dbSNP
rs951389423 117 dbSNP
rs763632708 118 dbSNP
rs1394250512 125 dbSNP
rs1322653551 126 dbSNP
rs779826646 133 dbSNP
rs922225207 136 dbSNP
rs187742871 137 dbSNP
rs914304254 138 dbSNP
rs1443635232 139 dbSNP
rs564494785 143 dbSNP
rs112675295 144 dbSNP
rs1041396487 145 dbSNP
rs1317251949 152 dbSNP
rs1210788045 155 dbSNP
rs1489707452 157 dbSNP
rs866686724 158 dbSNP
rs1245438449 163 dbSNP
rs1343160898 179 dbSNP
rs546659289 182 dbSNP
rs756718995 195 dbSNP
rs191431994 196 dbSNP
rs529170426 208 dbSNP
rs755706954 209 dbSNP
rs1056094900 222 dbSNP
rs960959039 226 dbSNP
rs1301078579 240 dbSNP
rs1423551932 245 dbSNP
rs1370821103 248 dbSNP
rs543585485 249 dbSNP
rs114982296 258 dbSNP
rs778242620 260 dbSNP
rs781689614 268 dbSNP
rs1372999209 283 dbSNP
rs41272172 284 dbSNP
rs1043234187 287 dbSNP
rs1483485414 291 dbSNP
rs925724850 291 dbSNP
rs1277091698 292 dbSNP
rs796185918 297 dbSNP
rs184374036 305 dbSNP
rs1039501629 307 dbSNP
rs1275518074 308 dbSNP
rs1387758636 311 dbSNP
rs539152524 313 dbSNP
rs1233808733 315 dbSNP
rs1347344575 321 dbSNP
rs866398753 327 dbSNP
rs189270770 330 dbSNP
rs566360271 333 dbSNP
rs1370764937 336 dbSNP
rs1046926038 344 dbSNP
rs1374607192 345 dbSNP
rs1407714364 352 dbSNP
rs377595930 355 dbSNP
rs887116254 358 dbSNP
rs181350370 377 dbSNP
rs1017456404 381 dbSNP
rs1302198995 385 dbSNP
rs3176358 386 dbSNP
rs1002260135 397 dbSNP
rs373590939 397 dbSNP
rs1454501485 398 dbSNP
rs1338842504 412 dbSNP
rs1363084136 416 dbSNP
rs866383890 416 dbSNP
rs976121091 430 dbSNP
rs1179838684 434 dbSNP
rs1296509107 440 dbSNP
rs575126168 442 dbSNP
rs1035203096 443 dbSNP
rs535732427 444 dbSNP
rs1309634071 451 dbSNP
rs960823517 458 dbSNP
rs922162572 467 dbSNP
rs1261233743 476 dbSNP
rs953675606 478 dbSNP
rs532581570 482 dbSNP
rs1281079083 488 dbSNP
rs777824384 489 dbSNP
rs879879447 493 dbSNP
rs1245700146 494 dbSNP
rs749588003 497 dbSNP
rs879309299 498 dbSNP
rs1176417316 499 dbSNP
rs1458233139 501 dbSNP
rs1410545818 513 dbSNP
rs557591236 514 dbSNP
rs1469781325 526 dbSNP
rs1238310449 527 dbSNP
rs914777007 529 dbSNP
rs978433655 530 dbSNP
rs1439329339 532 dbSNP
rs925725564 533 dbSNP
rs942480428 537 dbSNP
rs1039405016 541 dbSNP
rs575878563 545 dbSNP
rs1186756151 547 dbSNP
rs572991639 548 dbSNP
rs1241195720 553 dbSNP
rs946204604 587 dbSNP
rs1431092774 592 dbSNP
rs541799707 606 dbSNP
rs1286032990 612 dbSNP
rs1221894791 613 dbSNP
rs922442057 615 dbSNP
rs933792625 616 dbSNP
rs546335483 618 dbSNP
rs1047001332 625 dbSNP
rs1055493853 632 dbSNP
rs894366694 638 dbSNP
rs367706888 640 dbSNP
rs995702977 642 dbSNP
rs1316639627 646 dbSNP
rs1400543397 648 dbSNP
rs1414782201 651 dbSNP
rs184742749 655 dbSNP
rs941387040 656 dbSNP
rs1048397424 664 dbSNP
rs370572240 665 dbSNP
rs189202045 668 dbSNP
rs757862523 669 dbSNP
rs1289515919 683 dbSNP
rs540666701 692 dbSNP
rs1213364316 693 dbSNP
rs1446277683 700 dbSNP
rs1292232768 702 dbSNP
rs1247641087 708 dbSNP
rs774512258 709 dbSNP
rs1364417768 711 dbSNP
rs1004007357 717 dbSNP
rs1268992201 723 dbSNP
rs1014932119 733 dbSNP
rs1350764432 737 dbSNP
rs1305357860 741 dbSNP
rs1002289641 742 dbSNP
rs1365225649 743 dbSNP
rs1346497851 750 dbSNP
rs1225909893 754 dbSNP
rs1035067351 755 dbSNP
rs1169270853 760 dbSNP
rs997905489 770 dbSNP
rs1266718439 772 dbSNP
rs6457937 775 dbSNP
rs1269272527 778 dbSNP
rs529198430 781 dbSNP
rs990366166 796 dbSNP
rs544057426 812 dbSNP
rs1009737725 815 dbSNP
rs1021650885 821 dbSNP
rs968318210 822 dbSNP
rs1292832469 834 dbSNP
rs562367477 841 dbSNP
rs1214437185 843 dbSNP
rs139090547 846 dbSNP
rs967514962 851 dbSNP
rs980065929 853 dbSNP
rs1345101601 858 dbSNP
rs181534480 870 dbSNP
rs551145694 874 dbSNP
rs566590564 877 dbSNP
rs186592256 880 dbSNP
rs10046116 885 dbSNP
rs548971366 897 dbSNP
rs1401216744 907 dbSNP
rs567103693 914 dbSNP
rs772094412 918 dbSNP
rs991560468 919 dbSNP
rs1479367670 922 dbSNP
rs933848673 943 dbSNP
rs74801436 948 dbSNP
rs908342499 966 dbSNP
rs557652835 970 dbSNP
rs1203248566 971 dbSNP
rs1324860987 972 dbSNP
rs1265599057 987 dbSNP
rs1346545037 991 dbSNP
rs1323184962 998 dbSNP
rs1308173710 1008 dbSNP
rs1393307997 1013 dbSNP
rs1059247 1023 dbSNP
rs1486210553 1028 dbSNP
rs191000568 1031 dbSNP
rs1286834345 1032 dbSNP
rs1448911279 1043 dbSNP
rs1038653449 1049 dbSNP
rs1178582184 1050 dbSNP
rs375384268 1051 dbSNP
rs939842159 1055 dbSNP
rs1373329428 1061 dbSNP
rs1040878666 1067 dbSNP
rs540064877 1071 dbSNP
rs1258434302 1089 dbSNP
rs1308574600 1104 dbSNP
rs937985105 1105 dbSNP
rs776135188 1111 dbSNP
rs558063177 1112 dbSNP
rs889082589 1115 dbSNP
rs1261637880 1119 dbSNP
rs1011602474 1121 dbSNP
rs1315327520 1122 dbSNP
rs1306631788 1135 dbSNP
rs761473919 1142 dbSNP
rs1385000901 1148 dbSNP
rs1232064352 1152 dbSNP
rs1450298684 1161 dbSNP
rs573326094 1165 dbSNP
rs3176359 1166 dbSNP
rs903998141 1177 dbSNP
rs960052426 1184 dbSNP
rs1157825566 1190 dbSNP
rs555737213 1191 dbSNP
rs1386505260 1206 dbSNP
rs1181247844 1207 dbSNP
rs1461236031 1210 dbSNP
rs749899530 1213 dbSNP
rs1263105800 1224 dbSNP
rs1207246532 1226 dbSNP
rs573926464 1227 dbSNP
rs1223431084 1228 dbSNP
rs544119216 1234 dbSNP
rs1163000989 1236 dbSNP
rs930958513 1238 dbSNP
rs983778153 1243 dbSNP
rs1296287341 1251 dbSNP
rs1802569 1257 dbSNP
rs1383705783 1265 dbSNP
rs1382434582 1266 dbSNP
rs1297375941 1267 dbSNP
rs1424855287 1270 dbSNP
rs1426782231 1272 dbSNP
rs908447221 1273 dbSNP
rs1161106457 1277 dbSNP
rs1443541621 1279 dbSNP
rs1306606588 1281 dbSNP
rs1802570 1296 dbSNP
rs182235412 1299 dbSNP
rs185976780 1300 dbSNP
rs544851636 1304 dbSNP
rs1261412400 1309 dbSNP
rs1200644254 1311 dbSNP
rs1490893779 1314 dbSNP
rs1300371776 1319 dbSNP
rs1376345118 1321 dbSNP
rs1340234208 1328 dbSNP
rs1244523840 1350 dbSNP
rs963715824 1361 dbSNP
rs1324648171 1365 dbSNP
rs1277296198 1375 dbSNP
rs745953295 1380 dbSNP
rs1361208671 1382 dbSNP
rs932480638 1386 dbSNP
rs11550973 1388 dbSNP
rs527383432 1389 dbSNP
rs1396519804 1390 dbSNP
rs1169167214 1392 dbSNP
rs548775480 1394 dbSNP
rs1011571683 1397 dbSNP
rs1423597658 1398 dbSNP
rs73730143 1403 dbSNP
rs903433616 1404 dbSNP
rs982916069 1416 dbSNP
rs1267037831 1426 dbSNP
rs531369735 1431 dbSNP
rs778257166 1432 dbSNP
rs1194188901 1434 dbSNP
rs1183138065 1440 dbSNP
rs1337340457 1441 dbSNP
rs1257405417 1445 dbSNP
rs1223890425 1449 dbSNP
rs1036363838 1452 dbSNP
rs1385906506 1460 dbSNP
rs766360274 1460 dbSNP
rs1446722024 1461 dbSNP
rs1166317774 1462 dbSNP
rs564442732 1473 dbSNP
rs1419284609 1477 dbSNP
rs941154808 1479 dbSNP
rs1136646 1483 dbSNP
rs1471247583 1499 dbSNP
rs1427573585 1509 dbSNP
rs549777937 1512 dbSNP
rs1470615589 1515 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HepG2 , Hep3B , Huh-7 , SNU398 , SNU449 , SNU182 , SNU475
Disease MIMAT0002832
Location of target site 3'UTR
Tools used in this research EMBL , miRanda , TargetScan
Original Description (Extracted from the article) ... "we investigated the regulation of PTEN ...

- Fornari F; Milazzo M; Chieco P; Negrini M; et al., 2012, The Journal of pathology.

Article - Fornari F; Milazzo M; Chieco P; Negrini M; et al.
- The Journal of pathology, 2012
MiR-519d belongs to the chromosome 19 miRNA cluster (C19MC), the largest human miRNA cluster. One of its members, miR-519d, is over-expressed in hepatocellular carcinoma (HCC) and we characterized its contribution to hepatocarcinogenesis. In HCC cells, the over-expression of miR-519d promotes cell proliferation, invasion and impairs apoptosis following anticancer treatments. These functions are, at least in part, exerted through the direct targeting of CDKN1A/p21, PTEN, AKT3 and TIMP2. The mechanisms underlying miR-519d aberrant expression in HCC were assayed by genomic DNA amplification, methylation analysis and ChIP assay. The aberrant hypomethylation of C19MC and TP53 were respectively identified as an epigenetic change allowing the aberrant expression of miR-519d and one of the factors able to activate its transcription. In conclusion, we assessed the oncogenic role of miR-519d in HCC by characterizing its biological functions, including the modulation of response to anticancer treatments and by identifying CDKN1A/p21, PTEN, AKT3 and TIMP2 among its targets.
LinkOut: [PMID: 22262409]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_000389 | 3UTR | AGGAGGGAGACACUGGCCCCUCAAAUCGUCCAGCGACCUUCCUCAUCCACCCCAUCCCUCCCCAGUUCAUUGCACUUUGAUUAGCAGCGGAACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903826
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID21_NS
Location of target site NM_078467 | 3UTR | CACCCCAUCCCUCCCCAGUUCAUUGCACUUUGAUUAGCAGCGGAACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_000389 | 3UTR | UCAAUGGACUGGAAGGGGAAGGGACACACAAGAAGAAGGGCACCCUAGUUCUACCUCAGGCAGCUCAAGCAGCGACCGCCCCCUCCUCUAGCUGUGGGGGUGAGGGUCCCAUGUGGUGGCACAGGCCCCCUUGAGUGGGGUUAUCUCUGUGUUAGGGGUAUAUGAUGGGGGAGUAGAUCUUUCUAGGAGGGAGACACUGGCCCCUCAAAUCGUCCAGCGACCUUCCUCAUCCACCCCAUCCCUCCCCAGUUCAUUGCACUUUGAUUAGCAGCGGAACAAGGAGUCAGACAUUUUAAGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_000389 | 3UTR | UGGAAGGGGAAGGGACACACAAGAAGAAGGGCACCCUAGUUCUACCUCAGGCAGCUCAAGCAGCGACCGCCCCCUCCUCUAGCUGUGGGGGUGAGGGUCCCAUGUGGUGGCACAGGCCCCCUUGAGUGGGGUUAUCUCUGUGUUAGGGGUAUAUGAUGGGGGAGUAGAUCUUUCUAGGAGGGAGACACUGGCCCCUCAAAUCGUCCAGCGACCUUCCUCAUCCACCCCAUCCCUCCCCAGUUCAUUGCACUUUGAUUAGCAGCGGAACAAGGAGUCAGACAUUUUAAGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_000389 | 3UTR | UGGACUGGAAGGGGAAGGGACACACAAGAAGAAGGGCACCCUAGUUCUACCUCAGGCAGCUCAAGCAGCGACCGCCCCCUCCUCUAGCUGUGGGGGUGAGGGUCCCAUGUGGUGGCACAGGCCCCCUUGAGUGGGGUUAUCUCUGUGUUAGGGGUAUAUGAUGGGGGAGUAGAUCUUUCUAGGAGGGAGACACUGGCCCCUCAAAUCGUCCAGCGACCUUCCUCAUCCACCCCAUCCCUCCCCAGUUCAUUGCACUUUGAUUAGCAGCGGAACAAGGAGUCAGACAUUUUAAGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_000389 | 3UTR | GACUGGAAGGGGAAGGGACACACAAGAAGAAGGGCACCCUAGUUCUACCUCAGGCAGCUCAAGCAGCGACCGCCCCCUCCUCUAGCUGUGGGGGUGAGGGUCCCAUGUGGUGGCACAGGCCCCCUUGAGUGGGGUUAUCUCUGUGUUAGGGGUAUAUGAUGGGGGAGUAGAUCUUUCUAGGAGGGAGACACUGGCCCCUCAAAUCGUCCAGCGACCUUCCUCAUCCACCCCAUCCCUCCCCAGUUCAUUGCACUUUGAUUAGCAGCGGAACAAGGAGUCAGACAUUUUAAGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_078467 | 3UTR | GACUGGAAGGGGAAGGGACACACAAGAAGAAGGGCACCCUAGUUCUACCUCAGGCAGCUCAAGCAGCGACCGCCCCCUCCUCUAGCUGUGGGGGUGAGGGUCCCAUGUGGUGGCACAGGCCCCCUUGAGUGGGGUUAUCUCUGUGUUAGGGGUAUAUGAUGGGGGAGUAGAUCUUUCUAGGAGGGAGACACUGGCCCCUCAAAUCGUCCAGCGACCUUCCUCAUCCACCCCAUCCCUCCCCAGUUCAUUGCACUUUGAUUAGCAGCGGAACAAGGAGUCAGACAUUUUAAGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_000389 | 3UTR | GGACUGGAAGGGGAAGGGACACACAAGAAGAAGGGCACCCUAGUUCUACCUCAGGCAGCUCAAGCAGCGACCGCCCCCUCCUCUAGCUGUGGGGGUGAGGGUCCCAUGUGGUGGCACAGGCCCCCUUGAGUGGGGUUAUCUCUGUGUUAGGGGUAUAUGAUGGGGGAGUAGAUCUUUCUAGGAGGGAGACACUGGCCCCUCAAAUCGUCCAGCGACCUUCCUCAUCCACCCCAUCCCUCCCCAGUUCAUUGCACUUUGAUUAGCAGCGGAACAAGGAGUCAGACAUUUUAAGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.531 3.8e-3 -0.574 1.7e-3 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.403 2.3e-2 0.279 8.8e-2 25 Click to see details
GSE42095 Differentiated embryonic stem cells -0.371 4.1e-2 -0.639 5.2e-4 23 Click to see details
GSE17498 Multiple myeloma 0.271 4.5e-2 0.253 5.8e-2 40 Click to see details
GSE32688 Pancreatic cancer -0.26 7.5e-2 -0.273 6.5e-2 32 Click to see details
GSE38226 Liver fibrosis 0.322 7.7e-2 0.300 9.3e-2 21 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.282 1.1e-1 0.236 1.6e-1 20 Click to see details
GSE17306 Multiple myeloma -0.168 1.2e-1 0.428 1.1e-3 49 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.17 2.1e-1 0.229 1.4e-1 25 Click to see details
GSE14794 Lymphoblastoid cells -0.081 2.2e-1 -0.020 4.3e-1 90 Click to see details
GSE26953 Aortic valvular endothelial cells -0.154 2.4e-1 -0.254 1.2e-1 24 Click to see details
GSE28260 Renal cortex and medulla 0.201 2.6e-1 0.154 3.1e-1 13 Click to see details
GSE19350 CNS germ cell tumors -0.122 3.5e-1 0.068 4.2e-1 12 Click to see details
GSE27834 Pluripotent stem cells -0.09 3.7e-1 -0.103 3.5e-1 16 Click to see details
GSE21687 Ependynoma primary tumors 0.019 4.4e-1 0.125 1.6e-1 64 Click to see details
GSE21849 B cell lymphoma -0.012 4.8e-1 0.082 3.4e-1 29 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.001 5.0e-1 -0.167 3.5e-1 8 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.517 0.19 0.700 0.09 5 Click to see details
LIHC 0.599 0.2 0.800 0.1 4 Click to see details
HNSC -0.36 0.38 -0.500 0.33 3 Click to see details
HNSC -0.36 0.38 -0.500 0.33 3 Click to see details
HNSC -0.36 0.38 -0.500 0.33 3 Click to see details
HNSC -0.36 0.38 -0.500 0.33 3 Click to see details
325 hsa-miR-519c-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000496 HIF1A hypoxia inducible factor 1 alpha subunit 4 1
MIRT000998 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 4 3
MIRT003732 ELAVL1 ELAV like RNA binding protein 1 3 1
MIRT006639 TIMP2 TIMP metallopeptidase inhibitor 2 3 1
MIRT006640 PTEN phosphatase and tensin homolog 3 1
MIRT006641 CDKN1A cyclin dependent kinase inhibitor 1A 3 1
MIRT055028 TPRG1L tumor protein p63 regulated 1 like 2 2
MIRT055393 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT056828 REEP3 receptor accessory protein 3 2 2
MIRT060504 PPP6R3 protein phosphatase 6 regulatory subunit 3 2 2
MIRT061796 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 10
MIRT063354 ETNK1 ethanolamine kinase 1 2 2
MIRT064424 ARID4B AT-rich interaction domain 4B 2 2
MIRT064719 CCND2 cyclin D2 2 2
MIRT064805 ZBTB18 zinc finger and BTB domain containing 18 2 4
MIRT065609 DAZAP2 DAZ associated protein 2 2 10
MIRT065622 CLIC4 chloride intracellular channel 4 2 4
MIRT065872 GDF11 growth differentiation factor 11 2 2
MIRT065892 RAB5B RAB5B, member RAS oncogene family 2 8
MIRT068751 RB1 RB transcriptional corepressor 1 2 2
MIRT070050 FANCM Fanconi anemia complementation group M 2 2
MIRT071004 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT071334 CMPK1 cytidine/uridine monophosphate kinase 1 2 6
MIRT071912 ZFYVE9 zinc finger FYVE-type containing 9 2 2
MIRT072732 GLCE glucuronic acid epimerase 2 2
MIRT076028 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 6
MIRT076046 PITPNA phosphatidylinositol transfer protein alpha 2 2
MIRT079353 CCDC137 coiled-coil domain containing 137 2 2
MIRT080227 SMAD4 SMAD family member 4 2 6
MIRT081122 LDLR low density lipoprotein receptor 2 8
MIRT081205 MIDN midnolin 2 10
MIRT085098 IFNAR2 interferon alpha and beta receptor subunit 2 2 6
MIRT085149 SLC5A3 solute carrier family 5 member 3 2 4
MIRT086436 NABP1 nucleic acid binding protein 1 2 6
MIRT088037 UBXN2A UBX domain protein 2A 2 2
MIRT088132 SEPT2 septin 2 2 4
MIRT088343 MAPRE3 microtubule associated protein RP/EB family member 3 2 8
MIRT090645 U2SURP U2 snRNP associated SURP domain containing 2 6
MIRT090805 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT091692 TGFBR2 transforming growth factor beta receptor 2 2 4
MIRT092689 C3ORF38 chromosome 3 open reading frame 38 2 8
MIRT093954 SLAIN2 SLAIN motif family member 2 2 2
MIRT095727 ANKH ANKH inorganic pyrophosphate transport regulator 2 8
MIRT097158 FCHO2 FCH domain only 2 2 2
MIRT099319 QKI QKI, KH domain containing RNA binding 2 4
MIRT099835 SOX4 SRY-box 4 2 10
MIRT100773 ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2 2
MIRT100955 CENPQ centromere protein Q 2 4
MIRT102229 HBP1 HMG-box transcription factor 1 2 2
MIRT102299 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT102621 UBN2 ubinuclein 2 2 8
MIRT103780 PURB purine rich element binding protein B 2 2
MIRT104168 PHTF2 putative homeodomain transcription factor 2 2 6
MIRT107279 FAM73B mitoguardin 2 2 2
MIRT107945 TMEM2 transmembrane protein 2 2 2
MIRT108265 HABP4 hyaluronan binding protein 4 2 2
MIRT124812 BICD2 BICD cargo adaptor 2 2 2
MIRT138707 MPP5 membrane palmitoylated protein 5 2 2
MIRT139880 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT144312 NFAT5 nuclear factor of activated T-cells 5 2 8
MIRT145605 LASP1 LIM and SH3 protein 1 2 2
MIRT153350 MAVS mitochondrial antiviral signaling protein 2 4
MIRT153986 PRNP prion protein 2 2
MIRT159129 NRBP1 nuclear receptor binding protein 1 2 2
MIRT164533 MSMO1 methylsterol monooxygenase 1 2 2
MIRT165912 CREBRF CREB3 regulatory factor 2 2
MIRT170858 TAX1BP1 Tax1 binding protein 1 2 4
MIRT172157 FZD6 frizzled class receptor 6 2 8
MIRT173701 PRPF4 pre-mRNA processing factor 4 2 2
MIRT175003 ZBTB5 zinc finger and BTB domain containing 5 2 4
MIRT175400 ACSL4 acyl-CoA synthetase long chain family member 4 2 2
MIRT178069 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT178675 FAM102B family with sequence similarity 102 member B 2 2
MIRT180847 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 4
MIRT194911 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT195755 ATMIN ATM interactor 2 6
MIRT196623 TAOK1 TAO kinase 1 2 6
MIRT205286 STK11IP serine/threonine kinase 11 interacting protein 2 2
MIRT206051 PPARA peroxisome proliferator activated receptor alpha 2 2
MIRT206198 RAB10 RAB10, member RAS oncogene family 2 4
MIRT208980 SKIL SKI like proto-oncogene 2 10
MIRT223637 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT224757 DPYSL2 dihydropyrimidinase like 2 2 2
MIRT227995 NFIB nuclear factor I B 2 4
MIRT230973 PRRG4 proline rich and Gla domain 4 2 2
MIRT238183 ANKRD33B ankyrin repeat domain 33B 2 10
MIRT242425 HAS3 hyaluronan synthase 3 2 2
MIRT242666 SALL3 spalt like transcription factor 3 2 4
MIRT242765 FNBP1L formin binding protein 1 like 2 6
MIRT243095 LCLAT1 lysocardiolipin acyltransferase 1 2 4
MIRT243437 PAK2 p21 (RAC1) activated kinase 2 2 2
MIRT243964 MAP1B microtubule associated protein 1B 2 2
MIRT244776 RABGAP1 RAB GTPase activating protein 1 2 2
MIRT246630 TMEM109 transmembrane protein 109 2 2
MIRT246968 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT266055 FJX1 four jointed box 1 2 4
MIRT266858 SLC25A44 solute carrier family 25 member 44 2 2
MIRT283184 C16ORF52 chromosome 16 open reading frame 52 2 2
MIRT286955 SOCS7 suppressor of cytokine signaling 7 2 2
MIRT293651 PVR poliovirus receptor 2 4
MIRT295178 ZNF317 zinc finger protein 317 2 4
MIRT302453 CLIP4 CAP-Gly domain containing linker protein family member 4 2 2
MIRT303499 NAGK N-acetylglucosamine kinase 2 6
MIRT368755 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT383207 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT383610 POU2F1 POU class 2 homeobox 1 2 2
MIRT396102 CASP2 caspase 2 2 2
MIRT441419 FAM9C family with sequence similarity 9 member C 2 2
MIRT446818 C5orf30 chromosome 5 open reading frame 30 2 2
MIRT448307 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT461781 MPDU1 mannose-P-dolichol utilization defect 1 2 2
MIRT462816 NTN1 netrin 1 2 2
MIRT463613 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT464560 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT464842 RPS27A ribosomal protein S27a 2 12
MIRT465225 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT466446 TFAM transcription factor A, mitochondrial 2 8
MIRT466836 STX6 syntaxin 6 2 6
MIRT467185 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468179 SGMS1 sphingomyelin synthase 1 2 2
MIRT469850 PXK PX domain containing serine/threonine kinase like 2 8
MIRT471612 PAQR5 progestin and adipoQ receptor family member 5 2 19
MIRT472008 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT472159 NIN ninein 2 4
MIRT472336 NETO2 neuropilin and tolloid like 2 2 4
MIRT473162 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT473623 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT473682 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT473805 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT474416 KLHL28 kelch like family member 28 2 8
MIRT474736 KIF13A kinesin family member 13A 2 6
MIRT474966 KCTD10 potassium channel tetramerization domain containing 10 2 4
MIRT475464 HSPA8 heat shock protein family A (Hsp70) member 8 2 6
MIRT476120 GPR157 G protein-coupled receptor 157 2 2
MIRT476203 GNS glucosamine (N-acetyl)-6-sulfatase 2 6
MIRT477180 F3 coagulation factor III, tissue factor 2 8
MIRT478103 DLG5 discs large MAGUK scaffold protein 5 2 6
MIRT478713 CSNK1A1 casein kinase 1 alpha 1 2 6
MIRT479055 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 8
MIRT480008 CAPRIN2 caprin family member 2 2 4
MIRT480519 C11orf30 EMSY, BRCA2 interacting transcriptional repressor 2 10
MIRT480822 BLCAP bladder cancer associated protein 2 10
MIRT480944 BBX BBX, HMG-box containing 2 8
MIRT481336 ATL3 atlastin GTPase 3 2 2
MIRT481598 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT481877 ANKRD50 ankyrin repeat domain 50 2 2
MIRT482471 ADAR adenosine deaminase, RNA specific 2 4
MIRT484875 ZNF652 zinc finger protein 652 2 2
MIRT485090 SLC30A1 solute carrier family 30 member 1 2 4
MIRT485579 FOXQ1 forkhead box Q1 2 2
MIRT485618 FBXL5 F-box and leucine rich repeat protein 5 2 10
MIRT486751 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT489599 ZDHHC20 zinc finger DHHC-type containing 20 2 10
MIRT489889 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT491654 PDRG1 p53 and DNA damage regulated 1 2 10
MIRT492038 TSG101 tumor susceptibility 101 2 4
MIRT492361 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT492776 PDGFB platelet derived growth factor subunit B 2 2
MIRT493336 LAPTM4A lysosomal protein transmembrane 4 alpha 2 12
MIRT493611 HMGB3 high mobility group box 3 2 6
MIRT497468 DDR2 discoidin domain receptor tyrosine kinase 2 2 2
MIRT498059 SNX5 sorting nexin 5 2 6
MIRT499901 KIAA1191 KIAA1191 2 4
MIRT500489 ZBTB4 zinc finger and BTB domain containing 4 2 6
MIRT500685 TRIM37 tripartite motif containing 37 2 2
MIRT500760 TMEM127 transmembrane protein 127 2 6
MIRT501456 PTPN4 protein tyrosine phosphatase, non-receptor type 4 2 8
MIRT501559 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501983 MAPK1 mitogen-activated protein kinase 1 2 10
MIRT502000 MAP7 microtubule associated protein 7 2 8
MIRT502049 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 6
MIRT502423 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT503044 CAMSAP2 calmodulin regulated spectrin associated protein family member 2 2 2
MIRT503821 TMEM242 transmembrane protein 242 2 4
MIRT504290 PARP1 poly(ADP-ribose) polymerase 1 2 6
MIRT504560 ZNF417 zinc finger protein 417 2 6
MIRT505054 ZNF202 zinc finger protein 202 2 6
MIRT505486 SRSF2 serine and arginine rich splicing factor 2 2 4
MIRT505836 POLR1B RNA polymerase I subunit B 2 4
MIRT506372 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT506451 NACC2 NACC family member 2 2 4
MIRT506673 LZIC leucine zipper and CTNNBIP1 domain containing 2 4
MIRT506834 KIF23 kinesin family member 23 2 4
MIRT506880 KIAA0101 PCNA clamp associated factor 2 6
MIRT507359 FAM129A family with sequence similarity 129 member A 2 6
MIRT507957 BNIP2 BCL2 interacting protein 2 2 6
MIRT509433 MCM7 minichromosome maintenance complex component 7 2 6
MIRT510872 RAN RAN, member RAS oncogene family 2 8
MIRT511078 NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 2 4
MIRT511254 KLHL36 kelch like family member 36 2 6
MIRT513699 RBM20 RNA binding motif protein 20 2 4
MIRT513742 PKNOX1 PBX/knotted 1 homeobox 1 2 2
MIRT513981 CEP97 centrosomal protein 97 2 2
MIRT514092 EPS15L1 epidermal growth factor receptor pathway substrate 15 like 1 2 6
MIRT515928 MFAP2 microfibril associated protein 2 2 4
MIRT519574 ZNFX1 zinc finger NFX1-type containing 1 2 4
MIRT521297 RRAGD Ras related GTP binding D 2 4
MIRT521348 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT521693 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 8
MIRT521778 PPIG peptidylprolyl isomerase G 2 8
MIRT522191 NR2C2 nuclear receptor subfamily 2 group C member 2 2 6
MIRT524696 BTG3 BTG anti-proliferation factor 3 2 8
MIRT525663 NHSL2 NHS like 2 2 2
MIRT527252 TMEM196 transmembrane protein 196 2 2
MIRT527466 CLEC12B C-type lectin domain family 12 member B 2 2
MIRT529535 ICMT isoprenylcysteine carboxyl methyltransferase 2 2
MIRT530146 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2 2
MIRT530851 RAG1 recombination activating 1 2 4
MIRT531109 PEX13 peroxisomal biogenesis factor 13 2 2
MIRT534263 SLC12A7 solute carrier family 12 member 7 2 2
MIRT534756 RASGEF1A RasGEF domain family member 1A 2 2
MIRT535175 PLEKHB2 pleckstrin homology domain containing B2 2 2
MIRT535246 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 4
MIRT535401 PER1 period circadian clock 1 2 2
MIRT536036 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT536347 LEFTY1 left-right determination factor 1 2 2
MIRT536413 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT536437 KMT2B lysine methyltransferase 2B 2 6
MIRT536604 IRF2 interferon regulatory factor 2 2 2
MIRT536642 INO80D INO80 complex subunit D 2 2
MIRT536860 HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2 2
MIRT537241 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2 2
MIRT537728 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT537988 DPP8 dipeptidyl peptidase 8 2 2
MIRT538037 DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 2 2
MIRT538255 CUL3 cullin 3 2 4
MIRT538525 CLCN3 chloride voltage-gated channel 3 2 2
MIRT538659 CCSAP centriole, cilia and spindle associated protein 2 2
MIRT538779 C7orf60 base methyltransferase of 25S rRNA 2 homolog 2 4
MIRT538849 BTG1 BTG anti-proliferation factor 1 2 2
MIRT538923 BRI3BP BRI3 binding protein 2 6
MIRT539114 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT539454 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT541085 RLIM ring finger protein, LIM domain interacting 2 2
MIRT543117 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT543181 FICD FIC domain containing 2 2
MIRT543575 RPF2 ribosome production factor 2 homolog 2 4
MIRT544113 IPMK inositol polyphosphate multikinase 2 2
MIRT544625 CSDE1 cold shock domain containing E1 2 2
MIRT544699 ZNF224 zinc finger protein 224 2 4
MIRT544992 MFF mitochondrial fission factor 2 4
MIRT546248 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT546282 TMEM30A transmembrane protein 30A 2 4
MIRT546290 TMEM200C transmembrane protein 200C 2 4
MIRT546558 SATB2 SATB homeobox 2 2 2
MIRT546815 RAP2C RAP2C, member of RAS oncogene family 2 2
MIRT547046 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT547474 MBNL3 muscleblind like splicing regulator 3 2 4
MIRT547761 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT547892 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT548315 EPHA4 EPH receptor A4 2 2
MIRT548383 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 4
MIRT548460 EGLN3 egl-9 family hypoxia inducible factor 3 2 2
MIRT548579 DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 2 2
MIRT548858 CERCAM cerebral endothelial cell adhesion molecule 2 2
MIRT548896 CHEK2 checkpoint kinase 2 2 4
MIRT549319 ARHGAP12 Rho GTPase activating protein 12 2 4
MIRT550302 ZNF681 zinc finger protein 681 2 2
MIRT551120 ZNF107 zinc finger protein 107 2 2
MIRT551406 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT552173 DAD1 defender against cell death 1 2 2
MIRT552856 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT552892 WASL Wiskott-Aldrich syndrome like 2 4
MIRT553075 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT553668 TFAP4 transcription factor AP-4 2 4
MIRT553700 TCF7L2 transcription factor 7 like 2 2 2
MIRT554608 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT554860 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT556157 MECP2 methyl-CpG binding protein 2 2 2
MIRT556179 MCC mutated in colorectal cancers 2 2
MIRT556529 LIN52 lin-52 DREAM MuvB core complex component 2 2
MIRT556723 KLHL21 kelch like family member 21 2 4
MIRT557054 HOXB3 homeobox B3 2 2
MIRT557587 GNPTAB N-acetylglucosamine-1-phosphate transferase alpha and beta subunits 2 2
MIRT557661 GATA6 GATA binding protein 6 2 2
MIRT557753 FRS2 fibroblast growth factor receptor substrate 2 2 2
MIRT557881 FEM1B fem-1 homolog B 2 4
MIRT558215 EFCAB14 EF-hand calcium binding domain 14 2 4
MIRT558264 DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 2 2
MIRT558327 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT558766 CFL2 cofilin 2 2 2
MIRT561037 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT561324 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT561641 RUNX3 runt related transcription factor 3 2 2
MIRT562555 CCDC71L coiled-coil domain containing 71 like 2 4
MIRT562961 LRPAP1 LDL receptor related protein associated protein 1 2 2
MIRT564680 ZNF35 zinc finger protein 35 2 2
MIRT565694 SESN3 sestrin 3 2 2
MIRT565910 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT566141 RACGAP1 Rac GTPase activating protein 1 2 2
MIRT567047 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT567076 KBTBD2 kelch repeat and BTB domain containing 2 2 2
MIRT567539 FGFR1OP FGFR1 oncogene partner 2 2
MIRT567624 FAM210A family with sequence similarity 210 member A 2 2
MIRT570321 ZNF70 zinc finger protein 70 2 2
MIRT571759 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT571857 NKIRAS1 NFKB inhibitor interacting Ras like 1 2 2
MIRT573372 LIMA1 LIM domain and actin binding 1 2 2
MIRT574561 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT614729 ATAT1 alpha tubulin acetyltransferase 1 2 4
MIRT617877 ESR1 estrogen receptor 1 2 2
MIRT624421 CBX8 chromobox 8 2 2
MIRT625865 SLC35C2 solute carrier family 35 member C2 2 2
MIRT630703 DICER1 dicer 1, ribonuclease III 2 4
MIRT632514 PTPN9 protein tyrosine phosphatase, non-receptor type 9 2 2
MIRT641797 USP32 ubiquitin specific peptidase 32 2 2
MIRT663625 SEC23B Sec23 homolog B, coat complex II component 2 2
MIRT680135 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT702388 KLF10 Kruppel like factor 10 2 2
MIRT707830 TMEM133 transmembrane protein 133 2 2
MIRT708885 MOCS2 molybdenum cofactor synthesis 2 2 2
MIRT709122 C3orf18 chromosome 3 open reading frame 18 2 2
MIRT709635 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT710596 CDCA4 cell division cycle associated 4 2 2
MIRT710802 IFNLR1 interferon lambda receptor 1 2 2
MIRT711782 RFXAP regulatory factor X associated protein 2 2
MIRT713344 KLRD1 killer cell lectin like receptor D1 2 2
MIRT713640 MED8 mediator complex subunit 8 2 2
MIRT713916 IGF2R insulin like growth factor 2 receptor 2 2
MIRT715068 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715206 FKTN fukutin 2 2
MIRT717819 FAM114A1 family with sequence similarity 114 member A1 2 2
MIRT720543 CHERP calcium homeostasis endoplasmic reticulum protein 2 2
MIRT720636 ELF5 E74 like ETS transcription factor 5 2 2
MIRT721703 ISY1 ISY1 splicing factor homolog 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-519c Bilobalide NULL 73581 Quantitative real-time PCR Human breast cancer MCF-7 cells 21796641 2011 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-519c Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-519c-3p Mitoxantrone 4212 NSC279836 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-519c-3p Cisplatin 5460033 NSC119875 approved resistant High Germ Cell Tumor cell line (NTERA-2)
hsa-miR-519c-3p Vinorelbine 44424639 approved resistant High Non-Small Cell Lung Cancer cell line (H358, H1993)
hsa-miR-519c-3p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-519c-3p Gemcitabine 60750 NSC613327 approved sensitive Low Pancreatic Cancer cell line (MIA-PaCa-2)
hsa-miR-519c-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-519c-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-519c-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-519c-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-519c-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-519c-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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