miRTarBase - #MIRT006957


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pre-miRNA Information
pre-miRNA hsa-mir-137   
Genomic Coordinates chr1: 98046070 - 98046171
Description Homo sapiens miR-137 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-137
Sequence 59| UUAUUGCUUAAGAAUACGCGUAG |81
Evidence Experimental
Experiments Cloned
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B41RDC miR-137 Safety Biomarker (SAF) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol ESRRA   
Synonyms ERR1, ERRa, ERRalpha, ESRL1, NR3B1
Description estrogen related receptor alpha
Transcript NM_004451   
Expression
Putative miRNA Targets on ESRRA
3'UTR of ESRRA
(miRNA target sites are highlighted)		 
>ESRRA|NM_004451|3'UTR
   1 GGCAAGGGGTGGGACTGGTGGGGGTTCTGGCAGGACCTGCCTAGCATGGGGTCAGCCCCAAGGGCTGGGGCGGAGCTGGG
  81 GTCTGGGCAGTGCCACAGCCTGCTGGCAGGGCCAGGGCAATGCCATCAGCCCCTGGGAACAGGCCCCACGCCCTCTCCTC
 161 CCCCTCCTAGGGGGTGTCAGAAGCTGGGAACGTGTGTCCAGGCTCTGGGCACAGTGCTGCCCCTTGCAAGCCATAACGTG
 241 CCCCCAGAGTGTAGGGGGCCTTGCGGAAGCCATAGGGGGCTGCACGGGATGCGTGGGAGGCAGAAACCTATCTCAGGGAG
 321 GGAAGGGGATGGAGGCCAGAGTCTCCCAGTGGGTGATGCTTTTGCTGCTGCTTAATCCTACCCCCTCTTCAAAGCAGAGT
 401 GGGACTTGGAGAGCAAAGGCCCATGCCCCCTTCGCTCCTCCTCTCATCATTTGCATTGGGCATTAGTGTCCCCCCTTGAA
 481 GCAATAACTCCAAGCAGACTCCAGCCCCTGGACCCCTGGGGTGGCCAGGGCTTCCCCATCAGCTCCCAACGAGCCTCCTC
 561 AGGGGGTAGGAGAGCACTGCCTCTATGCCCTGCAGAGCAATAACACTATATTTATTTTTGGGTTTGGCCAGGGAGGCGCA
 641 GGGACATGGGGCAAGCCAGGGCCCAGAGCCCTTGGCTGTACAGAGACTCTATTTTAATGTATATTTGCTGCAAAGAGAAA
 721 CCGCTTTTGGTTTTAAACCTTTAATGAGAAAAAAATATATAATACCGAGCTCAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaugcgcauaaGAA-UUCGUUAUu 5'
                     ||| |||||||| 
Target 5' tagtgtcccccCTTGAAGCAATAa 3'
 464 - 487 152.00 -10.80
2 
miRNA  3' gaugcgcauaagaaUUCGUUAUu 5'
                        :||||||| 
Target 5' ctctatgccctgcaGAGCAATAa 3'
 581 - 603 141.00 -12.64
3 
miRNA  3' gaugcgcauaaGAA--UUCGUUAUu 5'
                     |||  |||| ||| 
Target 5' cagtgctgcccCTTGCAAGCCATAa 3'
 212 - 236 118.00 -5.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26548000 5 COSMIC
COSN30175436 35 COSMIC
COSN30147687 49 COSMIC
COSN26678975 123 COSMIC
COSN13339049 137 COSMIC
COSN31540091 151 COSMIC
COSN26649288 220 COSMIC
COSN26564195 252 COSMIC
COSN10090520 402 COSMIC
COSN31960640 639 COSMIC
COSN31547245 718 COSMIC
COSN17076185 759 COSMIC
COSN30525184 768 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs373632323 2 dbSNP
rs1174626807 3 dbSNP
rs200939335 5 dbSNP
rs755538454 6 dbSNP
rs1377813942 10 dbSNP
rs765753980 14 dbSNP
rs752497198 15 dbSNP
rs1172022228 16 dbSNP
rs539293877 21 dbSNP
rs1249425751 30 dbSNP
rs756971618 33 dbSNP
rs1408607741 35 dbSNP
rs1326394899 41 dbSNP
rs202093461 43 dbSNP
rs745402851 44 dbSNP
rs755560680 46 dbSNP
rs1343164278 49 dbSNP
rs1222761542 53 dbSNP
rs914406919 61 dbSNP
rs1638554 63 dbSNP
rs538292483 69 dbSNP
rs1391509741 72 dbSNP
rs565652556 76 dbSNP
rs1274170663 79 dbSNP
rs1042054297 80 dbSNP
rs1344586273 81 dbSNP
rs1298348148 86 dbSNP
rs1452033437 89 dbSNP
rs1339187292 96 dbSNP
rs1336764159 106 dbSNP
rs928611879 110 dbSNP
rs938625994 118 dbSNP
rs771439016 120 dbSNP
rs1427350855 133 dbSNP
rs534444692 137 dbSNP
rs1168619707 138 dbSNP
rs1472199042 138 dbSNP
rs1345958209 144 dbSNP
rs554238999 148 dbSNP
rs769389335 150 dbSNP
rs1250712844 151 dbSNP
rs775203872 152 dbSNP
rs1202777946 171 dbSNP
rs1484130829 172 dbSNP
rs887305726 186 dbSNP
rs1004462251 192 dbSNP
rs1354395447 193 dbSNP
rs1265004314 194 dbSNP
rs1019864636 196 dbSNP
rs1246256892 203 dbSNP
rs901434390 203 dbSNP
rs997103864 206 dbSNP
rs1487618839 214 dbSNP
rs1211904438 216 dbSNP
rs1371982632 218 dbSNP
rs1028626219 220 dbSNP
rs1472445616 226 dbSNP
rs1404224153 227 dbSNP
rs960776483 228 dbSNP
rs953107071 234 dbSNP
rs990329036 238 dbSNP
rs1021445854 239 dbSNP
rs373869986 242 dbSNP
rs1159181938 243 dbSNP
rs1221189527 249 dbSNP
rs1449935227 250 dbSNP
rs1348845080 251 dbSNP
rs977363025 257 dbSNP
rs1329028719 259 dbSNP
rs536856764 261 dbSNP
rs928503890 263 dbSNP
rs1230595687 265 dbSNP
rs1351545475 266 dbSNP
rs1279762279 274 dbSNP
rs1435222449 276 dbSNP
rs1329007534 277 dbSNP
rs938594807 279 dbSNP
rs79941458 280 dbSNP
rs1387776343 284 dbSNP
rs1156918795 286 dbSNP
rs1458605329 287 dbSNP
rs1412525467 293 dbSNP
rs915938280 295 dbSNP
rs577084478 298 dbSNP
rs931403883 300 dbSNP
rs1248698249 304 dbSNP
rs1199626214 307 dbSNP
rs1048993404 309 dbSNP
rs887281778 311 dbSNP
rs1211191578 326 dbSNP
rs879870280 327 dbSNP
rs1408935155 335 dbSNP
rs940146718 338 dbSNP
rs1041203044 340 dbSNP
rs901403285 346 dbSNP
rs546063442 348 dbSNP
rs997071212 353 dbSNP
rs1276290102 356 dbSNP
rs1028596408 357 dbSNP
rs552030809 371 dbSNP
rs1224326228 375 dbSNP
rs1011316038 380 dbSNP
rs1021831437 381 dbSNP
rs967163028 383 dbSNP
rs558710973 386 dbSNP
rs1320036546 400 dbSNP
rs1187966042 403 dbSNP
rs1173430435 406 dbSNP
rs759326321 410 dbSNP
rs1448931486 412 dbSNP
rs768132860 419 dbSNP
rs959927449 421 dbSNP
rs991435912 424 dbSNP
rs1465704541 434 dbSNP
rs1237442567 435 dbSNP
rs1292712046 435 dbSNP
rs1208420575 437 dbSNP
rs1314358270 438 dbSNP
rs915908870 438 dbSNP
rs879108253 440 dbSNP
rs1234656491 456 dbSNP
rs952864064 457 dbSNP
rs190992629 471 dbSNP
rs775503688 474 dbSNP
rs1362527581 482 dbSNP
rs1404344261 485 dbSNP
rs1445516229 489 dbSNP
rs1360745929 491 dbSNP
rs984142546 496 dbSNP
rs908585227 500 dbSNP
rs41294424 506 dbSNP
rs1170520564 507 dbSNP
rs1181830488 509 dbSNP
rs1429237586 511 dbSNP
rs1413676307 513 dbSNP
rs1412303183 515 dbSNP
rs1180683934 519 dbSNP
rs1421495847 527 dbSNP
rs1166314308 538 dbSNP
rs1204911096 541 dbSNP
rs1482497750 546 dbSNP
rs1272082787 551 dbSNP
rs1307626489 553 dbSNP
rs1311910649 559 dbSNP
rs1226467391 563 dbSNP
rs1041170409 564 dbSNP
rs1428784565 565 dbSNP
rs761700423 566 dbSNP
rs1372228591 567 dbSNP
rs879483780 573 dbSNP
rs561379177 576 dbSNP
rs1162778561 577 dbSNP
rs530174517 579 dbSNP
rs1376912875 580 dbSNP
rs544054283 582 dbSNP
rs1315824478 584 dbSNP
rs3204919 584 dbSNP
rs183554515 588 dbSNP
rs888783404 592 dbSNP
rs1011618680 593 dbSNP
rs866252902 596 dbSNP
rs1264286551 606 dbSNP
rs1277175724 622 dbSNP
rs369242666 628 dbSNP
rs1308408132 631 dbSNP
rs187444371 633 dbSNP
rs1227530253 639 dbSNP
rs1236176902 643 dbSNP
rs1042743595 649 dbSNP
rs373707219 651 dbSNP
rs1392113548 656 dbSNP
rs565583510 661 dbSNP
rs11541032 662 dbSNP
rs998629803 667 dbSNP
rs1459540952 673 dbSNP
rs1448477431 674 dbSNP
rs679730 676 dbSNP
rs572460127 677 dbSNP
rs1455966422 682 dbSNP
rs1035509985 686 dbSNP
rs1182998472 688 dbSNP
rs1419248910 708 dbSNP
rs1266267807 714 dbSNP
rs1410274107 716 dbSNP
rs959897966 718 dbSNP
rs1253533713 724 dbSNP
rs1357289462 725 dbSNP
rs1327001716 739 dbSNP
rs1467580819 745 dbSNP
rs1239474197 748 dbSNP
rs1012838753 749 dbSNP
rs1371741948 749 dbSNP
rs567342412 749 dbSNP
rs1023266425 752 dbSNP
rs149984080 755 dbSNP
rs1391447686 756 dbSNP
rs1159552492 757 dbSNP
rs1364600564 760 dbSNP
rs145155074 761 dbSNP
rs1455196292 764 dbSNP
rs1253159020 766 dbSNP
rs1187374559 774 dbSNP
rs760509012 775 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hep G2
Location of target site 3'UTR
Tools used in this research miRanda , PicTar , TargetScan
Original Description (Extracted from the article) ... ESRRA 3'UTR is a specific direct target of miR-137. ...

- Zhao Y; Li Y; Lou G; Zhao L; Xu Z; Zhang Y; He F, 2012, PloS one.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaugcgcauaagaaUUCGUUAUu 5'
                        :||||||| 
Target 5' cucuaugcccugcaGAGCAAUAa 3'
 		1 - 23
Article - Zhao Y; Li Y; Lou G; Zhao L; Xu Z; Zhang Y; He F
- PloS one, 2012
ERRalpha is an orphan nuclear receptor emerging as a novel biomarker of breast cancer. Over-expression of ERRalpha in breast tumor is considered as a prognostic factor of poor clinical outcome. The mechanisms underlying the dysexpression of this nuclear receptor, however, are poorly understood. MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level and play important roles in tumor initiation and progression. In the present study, we have identified that the expression of ERRalpha is regulated by miR-137, a potential tumor suppressor microRNA. The bioinformatics search revealed two putative and highly conserved target-sites for miR-137 located within the ERRalpha 3'UTR at nt 480-486 and nt 596-602 respectively. Luciferase-reporter assay demonstrated that the two predicted target sites were authentically functional. They mediated the repression of reporter gene expression induced by miR-137 in an additive manner. Moreover, ectopic expression of miR-137 down-regulated ERRalpha expression at both protein level and mRNA level, and the miR-137 induced ERRalpha-knockdown contributed to the impaired proliferative and migratory capacity of breast cancer cells. Furthermore, transfection with miR-137 mimics suppressed at least two downstream target genes of ERRalpha-CCNE1 and WNT11, which are important effectors of ERRalpha implicated in tumor proliferation and migration. Taken together, our results establish a role of miR-137 in negatively regulating ERRalpha expression and breast cancer cell proliferation and migration. They suggest that manipulating the expression level of ERRalpha by microRNAs has the potential to influence breast cancer progression.
LinkOut: [PMID: 22723937]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.775 9.3e-4 -0.588 1.7e-2 13 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.56 1.8e-3 0.530 3.2e-3 25 Click to see details
GSE27834 Pluripotent stem cells -0.497 2.5e-2 0.079 3.9e-1 16 Click to see details
GSE19350 CNS germ cell tumors 0.566 2.8e-2 0.577 2.5e-2 12 Click to see details
GSE38226 Liver fibrosis 0.404 3.5e-2 0.348 6.1e-2 21 Click to see details
GSE21687 Ependynoma primary tumors 0.185 7.2e-2 0.146 1.2e-1 64 Click to see details
GSE28544 Breast cancer -0.24 1.3e-1 -0.208 1.6e-1 24 Click to see details
GSE26953 Aortic valvular endothelial cells 0.223 1.5e-1 0.224 1.5e-1 24 Click to see details
GSE32688 Pancreatic cancer 0.117 2.6e-1 -0.113 2.7e-1 32 Click to see details
GSE21849 B cell lymphoma 0.121 2.7e-1 0.386 1.9e-2 29 Click to see details
GSE42095 Differentiated embryonic stem cells 0.125 2.8e-1 0.088 3.4e-1 23 Click to see details
GSE17498 Multiple myeloma -0.076 3.2e-1 -0.047 3.9e-1 40 Click to see details
GSE14794 Lymphoblastoid cells -0.014 4.5e-1 0.016 4.4e-1 90 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.001 5.0e-1 0.373 5.3e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.001 5.0e-1 0.373 5.3e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.001 5.0e-1 0.373 5.3e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.001 5.0e-1 0.373 5.3e-2 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA -0.921 0 -0.829 0.02 6 Click to see details
KICH -0.966 0.02 -0.800 0.1 4 Click to see details
PRAD 0.331 0.06 0.351 0.05 24 Click to see details
KIRP -0.597 0.06 -0.595 0.06 8 Click to see details
ESCA -0.797 0.1 -0.800 0.1 4 Click to see details
UCEC -0.732 0.13 -0.400 0.3 4 Click to see details
THCA 0.18 0.18 0.222 0.13 27 Click to see details
PCPG 0.765 0.22 0.500 0.33 3 Click to see details
CHOL 0.426 0.29 0.600 0.2 4 Click to see details
LUSC 0.21 0.33 0.214 0.32 7 Click to see details
PAAD 0.291 0.35 0.200 0.4 4 Click to see details
BLCA 0.202 0.4 0.600 0.2 4 Click to see details
LIHC 0.195 0.44 0.500 0.33 3 Click to see details
HNSC -0.026 0.45 -0.169 0.19 29 Click to see details
STAD -0.01 0.49 -0.253 0.2 13 Click to see details
STAD -0.01 0.49 -0.253 0.2 13 Click to see details
STAD -0.01 0.49 -0.253 0.2 13 Click to see details
STAD -0.01 0.49 -0.253 0.2 13 Click to see details
140 hsa-miR-137 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT002489 E2F6 E2F transcription factor 6 4 1
MIRT002490 CDK6 cyclin dependent kinase 6 4 7
MIRT004004 NCOA2 nuclear receptor coactivator 2 4 1
MIRT004579 KDM1A lysine demethylase 1A 5 3
MIRT005485 CDC42 cell division cycle 42 4 4
MIRT005605 CTBP1 C-terminal binding protein 1 4 1
MIRT005883 MITF melanogenesis associated transcription factor 3 1
MIRT006329 PTGS2 prostaglandin-endoperoxide synthase 2 2 1
MIRT006957 ESRRA estrogen related receptor alpha 1 1
MIRT007068 ZNF804A zinc finger protein 804A 1 1
MIRT007092 YBX1 Y-box binding protein 1 3 3
MIRT007252 CSE1L chromosome segregation 1 like 2 1
MIRT007346 PXN paxillin 3 1
MIRT053056 GLIPR1 GLI pathogenesis related 1 3 1
MIRT053225 MET MET proto-oncogene, receptor tyrosine kinase 3 1
MIRT054547 FUNDC1 FUN14 domain containing 1 3 1
MIRT054568 BNIP3L BCL2 interacting protein 3 like 3 1
MIRT090615 PLS1 plastin 1 2 2
MIRT093393 TMA16 translation machinery associated 16 homolog 2 2
MIRT109230 VMA21 VMA21, vacuolar ATPase assembly factor 2 6
MIRT153687 NCOA3 nuclear receptor coactivator 3 2 2
MIRT170929 FOXK1 forkhead box K1 2 2
MIRT219251 RREB1 ras responsive element binding protein 1 2 2
MIRT259552 KLHL15 kelch like family member 15 2 4
MIRT271869 ZNF678 zinc finger protein 678 2 2
MIRT280623 BCL11B B-cell CLL/lymphoma 11B 2 8
MIRT293284 DR1 down-regulator of transcription 1 2 2
MIRT314017 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 8
MIRT374677 AGO4 argonaute 4, RISC catalytic component 2 2
MIRT437385 FMNL2 formin like 2 1 1
MIRT437406 RORA RAR related orphan receptor A 1 1
MIRT437423 KIT KIT proto-oncogene receptor tyrosine kinase 3 1
MIRT437424 AKT2 AKT serine/threonine kinase 2 5 4
MIRT437425 TGFB2 transforming growth factor beta 2 3 1
MIRT437804 SERPINA3 serpin family A member 3 1 1
MIRT437978 COX2 cytochrome c oxidase subunit II 3 1
MIRT438078 TRIM13 tripartite motif containing 13 4 1
MIRT438287 TBX3 T-box 3 1 1
MIRT438288 KLF4 Kruppel like factor 4 1 1
MIRT438537 MTDH metadherin 2 1
MIRT438757 Nr1i3 nuclear receptor subfamily 1, group I, member 3 2 1
MIRT442564 CCDC59 coiled-coil domain containing 59 2 2
MIRT442778 JAG1 jagged 1 2 2
MIRT444302 SREK1IP1 SREK1 interacting protein 1 2 2
MIRT446969 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT448824 FKBP1A FK506 binding protein 1A 2 4
MIRT453617 SNRPE small nuclear ribonucleoprotein polypeptide E 2 4
MIRT459217 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT463490 ZC3H11A zinc finger CCCH-type containing 11A 2 12
MIRT470084 PTGES2 prostaglandin E synthase 2 2 2
MIRT475876 H3F3C H3 histone family member 3C 2 10
MIRT475912 H3F3B H3 histone family member 3B 2 8
MIRT476669 FUT11 fucosyltransferase 11 2 10
MIRT477346 EOGT EGF domain specific O-linked N-acetylglucosamine transferase 2 4
MIRT477596 EIF1 eukaryotic translation initiation factor 1 2 10
MIRT478367 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT479111 CNN2 calponin 2 2 2
MIRT482926 CTPS2 CTP synthase 2 2 2
MIRT485083 SNRK SNF related kinase 2 12
MIRT497120 NBEAL1 neurobeachin like 1 2 2
MIRT498029 UBXN4 UBX domain protein 4 2 8
MIRT500603 UBE2Z ubiquitin conjugating enzyme E2 Z 2 4
MIRT500927 SSFA2 sperm specific antigen 2 2 8
MIRT504324 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT504647 RPL9 ribosomal protein L9 2 6
MIRT506304 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT508007 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT510538 XKR7 XK related 7 2 2
MIRT513051 LYPD6 LY6/PLAUR domain containing 6 2 6
MIRT515223 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT519857 ZFP62 ZFP62 zinc finger protein 2 6
MIRT520508 TRAM2 translocation associated membrane protein 2 2 6
MIRT522047 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT524479 CHRM3 cholinergic receptor muscarinic 3 2 4
MIRT526904 ZNF772 zinc finger protein 772 2 6
MIRT527862 SLC39A14 solute carrier family 39 member 14 2 2
MIRT528601 ZNF326 zinc finger protein 326 2 2
MIRT532950 ZNF24 zinc finger protein 24 2 4
MIRT536275 LMOD2 leiomodin 2 2 2
MIRT537045 GRAMD4 GRAM domain containing 4 2 2
MIRT537124 GOLGA3 golgin A3 2 4
MIRT538884 BTBD1 BTB domain containing 1 2 2
MIRT541457 AURKA aurora kinase A 2 2
MIRT542924 HOXC8 homeobox C8 2 2
MIRT544580 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT545175 RFTN2 raftlin family member 2 2 2
MIRT545248 GTF2E1 general transcription factor IIE subunit 1 2 2
MIRT546473 SLC1A5 solute carrier family 1 member 5 2 2
MIRT547523 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT548071 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548200 FNIP1 folliculin interacting protein 1 2 2
MIRT551216 CIDEC cell death inducing DFFA like effector c 2 2
MIRT553046 USP28 ubiquitin specific peptidase 28 2 2
MIRT553875 SUPT7L SPT7 like, STAGA complex gamma subunit 2 4
MIRT554026 SPCS3 signal peptidase complex subunit 3 2 2
MIRT554153 SLX4 SLX4 structure-specific endonuclease subunit 2 2
MIRT554192 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT554362 SFXN5 sideroflexin 5 2 4
MIRT555349 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT555822 PAX9 paired box 9 2 2
MIRT555866 PAIP1 poly(A) binding protein interacting protein 1 2 2
MIRT555931 NUP43 nucleoporin 43 2 2
MIRT555993 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT556429 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT556582 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT557220 HNRNPDL heterogeneous nuclear ribonucleoprotein D like 2 2
MIRT558490 DBN1 drebrin 1 2 2
MIRT560986 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT562291 GLO1 glyoxalase I 2 2
MIRT564093 TLR3 toll like receptor 3 2 2
MIRT565312 TMEM41A transmembrane protein 41A 2 2
MIRT565424 TEF TEF, PAR bZIP transcription factor 2 2
MIRT566946 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT572369 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT686211 ZNF267 zinc finger protein 267 2 2
MIRT686935 SFT2D3 SFT2 domain containing 3 2 2
MIRT687448 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT710856 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT719484 RBM27 RNA binding motif protein 27 2 2
MIRT719813 TXNDC17 thioredoxin domain containing 17 2 2
MIRT720076 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT723920 ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 2 2
MIRT731305 CUL4A cullin 4A 3 1
MIRT732128 BMP7 bone morphogenetic protein 7 2 1
MIRT732466 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3 0
MIRT732962 TNC tenascin C 1 0
MIRT734856 KDM4A lysine demethylase 4A 3 0
MIRT735625 MEF2A myocyte enhancer factor 2A 2 0
MIRT735795 IL6 interleukin 6 3 0
MIRT736333 DELE1 KIAA0141 2 0
MIRT736610 RUNX2 runt related transcription factor 2 3 0
MIRT736830 NOTCH1 notch 1 3 0
MIRT736888 KCNA2 potassium voltage-gated channel subfamily A member 2 3 0
MIRT737349 EGFR epidermal growth factor receptor 3 0
MIRT755368 GLS glutaminase 2 1
MIRT755431 SPHK2 sphingosine kinase 2 3 1
MIRT756119 USP30 ubiquitin specific peptidase 30 4 1
MIRT756144 XIAP X-linked inhibitor of apoptosis 3 1
MIRT756170 COL5A1 collagen type V alpha 1 chain 3 1
MIRT756171 FSTL1 follistatin like 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-137 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-137 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-137 Emodin NULL 3220 Microarray K562 cells 23744534 2013 down-regualted
miR-137 Emodin NULL 3220 Quantitative real-time PCR K562 cells 23744534 2013 down-regualted
miR-137 Olea europaea leaf extract NULL NULL Quantitative real-time PCR Glioblastoma multiforme tumors cell lines 25232498 2014 up-regualted
miR-137 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-137 Ginsenoside Rh2 NULL 119307 Microarray human glioma cells U251 21372826 2011 up-regulated
miR-137 Interleukin 13 (IL-13) NULL NULL Quantitative real-time PCR esophageal squamous cells 22453679 2012 up-regulated
miR-137 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-137 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-137 Olea europaea leaf extract NULL NULL Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-137 Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-137 Nicotine approved 89594 Microarray Rat adrenal pheochromocytoma PC12 cell 18845019 2009 up-regulated
miR-137 Capecitabine approved 60953 Quantitative real-time PCR rectal cancer 18695884 2008 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-137 Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MDA-MB-231)
hsa-mir-137 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-137 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-137 Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-137 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-137 Topotecan 60699 NSC609699 approved resistant cell line (W1)

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