miRTarBase - #MIRT007032


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pre-miRNA Information
pre-miRNA hsa-mir-133a-1   
Genomic Coordinates chr18: 21825698 - 21825785
Synonyms MIRN133A1, MIR133A1
Description Homo sapiens miR-133a-1 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-133a-2   
Genomic Coordinates chr20: 62564912 - 62565013
Synonyms MIRN133A2, MIR133A2
Description Homo sapiens miR-133a-2 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-133a-3p
Sequence 53| UUUGGUCCCCUUCAACCAGCUG |74
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30104664 8 COSMIC
COSN30455205 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369575411 9 dbSNP
rs746815210 11 dbSNP
rs1382873526 13 dbSNP
rs553267926 15 dbSNP
rs1172821195 16 dbSNP
rs182673735 19 dbSNP
rs781929120 20 dbSNP
rs1296628341 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma .
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Muscle Reverse transcription-polymerase chain reaction
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma Real-time reverse transcription PCR
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Serum Real-time polymerase chain reaction
Gene Information
Gene Symbol EGFR   
Synonyms ERBB, ERBB1, HER1, NISBD2, PIG61, mENA
Description epidermal growth factor receptor
Transcript NM_005228   
Other Transcripts NM_201282 , NM_201283 , NM_201284   
Expression
Putative miRNA Targets on EGFR
3'UTR of EGFR
(miRNA target sites are highlighted)		 
>EGFR|NM_005228|3'UTR
   1 CCACGGAGGATAGTATGAGCCCTAAAAATCCAGACTCTTTCGATACCCAGGACCAAGCCACAGCAGGTCCTCCATCCCAA
  81 CAGCCATGCCCGCATTAGCTCTTAGACCCACAGACTGGTTTTGCAACGTTTACACCGACTAGCCAGGAAGTACTTCCACC
 161 TCGGGCACATTTTGGGAAGTTGCATTCCTTTGTCTTCAAACTGTGAAGCATTTACAGAAACGCATCCAGCAAGAATATTG
 241 TCCCTTTGAGCAGAAATTTATCTTTCAAAGAGGTATATTTGAAAAAAAAAAAAAGTATATGTGAGGATTTTTATTGATTG
 321 GGGATCTTGGAGTTTTTCATTGTCGCTATTGATTTTTACTTCAATGGGCTCTTCCAACAAGGAAGAAGCTTGCTGGTAGC
 401 ACTTGCTACCCTGAGTTCATCCAGGCCCAACTGTGAGCAAGGAGCACAAGCCACAAGTCTTCCAGAGGATGCTTGATTCC
 481 AGTGGTTCTGCTTCAAGGCTTCCACTGCAAAACACTAAAGATCCAAGAAGGCCTTCATGGCCCCAGCAGGCCGGATCGGT
 561 ACTGTATCAAGTCATGGCAGGTACAGTAGGATAAGCCACTCTGTCCCTTCCTGGGCAAAGAAGAAACGGAGGGGATGGAA
 641 TTCTTCCTTAGACTTACTTTTGTAAAAATGTCCCCACGGTACTTACTCCCCACTGATGGACCAGTGGTTTCCAGTCATGA
 721 GCGTTAGACTGACTTGTTTGTCTTCCATTCCATTGTTTTGAAACTCAGTATGCTGCCCCTGTCTTGCTGTCATGAAATCA
 801 GCAAGAGAGGATGACACATCAAATAATAACTCGGATTCCAGCCCACATTGGATTCATCAGCATTTGGACCAATAGCCCAC
 881 AGCTGAGAATGTGGAATACCTAAGGATAGCACCGCTTTTGTTCTCGCAAAAACGTATCTCCTAATTTGAGGCTCAGATGA
 961 AATGCATCAGGTCCTTTGGGGCATAGATCAGAAGACTACAAAAATGAAGCTGCTCTGAAATCTCCTTTAGCCATCACCCC
1041 AACCCCCCAAAATTAGTTTGTGTTACTTATGGAAGATAGTTTTCTCCTTTTACTTCACTTCAAAAGCTTTTTACTCAAAG
1121 AGTATATGTTCCCTCCAGGTCAGCTGCCCCCAAACCCCCTCCTTACGCTTTGTCACACAAAAAGTGTCTCTGCCTTGAGT
1201 CATCTATTCAAGCACTTACAGCTCTGGCCACAACAGGGCATTTTACAGGTGCGAATGACAGTAGCATTATGAGTAGTGTG
1281 GAATTCAGGTAGTAAATATGAAACTAGGGTTTGAAATTGATAATGCTTTCACAACATTTGCAGATGTTTTAGAAGGAAAA
1361 AAGTTCCTTCCTAAAATAATTTCTCTACAATTGGAAGATTGGAAGATTCAGCTAGTTAGGAGCCCACCTTTTTTCCTAAT
1441 CTGTGTGTGCCCTGTAACCTGACTGGTTAACAGCAGTCCTTTGTAAACAGTGTTTTAAACTCTCCTAGTCAATATCCACC
1521 CCATCCAATTTATCAAGGAAGAAATGGTTCAGAAAATATTTTCAGCCTACAGTTATGTTCAGTCACACACACATACAAAA
1601 TGTTCCTTTTGCTTTTAAAGTAATTTTTGACTCCCAGATCAGTCAGAGCCCCTACAGCATTGTTAAGAAAGTATTTGATT
1681 TTTGTCTCAATGAAAATAAAACTATATTCATTTCCACTCTATTATGCTCTCAAATACCCCTAAGCATCTATACTAGCCTG
1761 GTATGGGTATGAAAGATACAAAGATAAATAAAACATAGTCCCTGATTCTAAGAAATTCACAATTTAGCAAAGGAAATGGA
1841 CTCATAGATGCTAACCTTAAAACAACGTGACAAATGCCAGACAGGACCCATCAGCCAGGCACTGTGAGAGCACAGAGCAG
1921 GGAGGTTGGGTCCTGCCTGAGGAGACCTGGAAGGGAGGCCTCACAGGAGGATGACCAGGTCTCAGTCAGCGGGGAGGTGG
2001 AAAGTGCAGGTGCATCAGGGGCACCCTGACCGAGGAAACAGCTGCCAGAGGCCTCCACTGCTAAAGTCCACATAAGGCTG
2081 AGGTCAGTCACCCTAAACAACCTGCTCCCTCTAAGCCAGGGGATGAGCTTGGAGCATCCCACAAGTTCCCTAAAAGTTGC
2161 AGCCCCCAGGGGGATTTTGAGCTATCATCTCTGCACATGCTTAGTGAGAAGACTACACAACATTTCTAAGAATCTGAGAT
2241 TTTATATTGTCAGTTAACCACTTTCATTATTCATTCACCTCAGGACATGCAGAAATATTTCAGTCAGAACTGGGAAACAG
2321 AAGGACCTACATTCTGCTGTCACTTATGTGTCAAGAAGCAGATGATCGATGAGGCAGGTCAGTTGTAAGTGAGTCACATT
2401 GTAGCATTAAATTCTAGTATTTTTGTAGTTTGAAACAGTAACTTAATAAAAGAGCAAAAGCTAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gucGACC-AACU--UC----CCCUGGUUu 5'
             :||| || |  ||     ||||||| 
Target 5' acaTTGGATTCATCAGCATTTGGACCAAt 3'
 845 - 873 143.00 -11.40
2 
miRNA  3' gucgaccaacuuccCCUGGUUu 5'
                        ||||||| 
Target 5' tctttcgatacccaGGACCAAg 3'
 36 - 57 140.00 -11.00
3 
miRNA  3' gucgaccaACUUCCCCUGGUUu 5'
                  |||   ||||||: 
Target 5' ctccccacTGA--TGGACCAGt 3'
 686 - 705 126.00 -10.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30166268 16 COSMIC
COSN30462442 38 COSMIC
COSN31515569 42 COSMIC
COSN30184467 50 COSMIC
COSN30151515 78 COSMIC
COSN30520259 92 COSMIC
COSN22155332 109 COSMIC
COSN31564140 209 COSMIC
COSN28881857 222 COSMIC
COSN30129898 223 COSMIC
COSN31543386 236 COSMIC
COSN16240588 237 COSMIC
COSN31598608 273 COSMIC
COSN22421942 277 COSMIC
COSN26669089 279 COSMIC
COSM96906 295 COSMIC
COSN9994282 367 COSMIC
COSN29235695 444 COSMIC
COSN17490771 583 COSMIC
COSN8029069 905 COSMIC
COSN9994283 915 COSMIC
COSN8029070 1063 COSMIC
COSN29604313 1127 COSMIC
COSN22842112 1149 COSMIC
COSN22294109 1162 COSMIC
COSN2229449 1282 COSMIC
COSN9994284 1326 COSMIC
COSN29272001 1363 COSMIC
COSN21087152 1655 COSMIC
COSN16524292 1666 COSMIC
COSN5102198 2133 COSMIC
COSN9767520 2267 COSMIC
COSN23838907 2602 COSMIC
COSN21470097 2658 COSMIC
COSN19343364 2749 COSMIC
COSN24420069 2887 COSMIC
COSN23841653 3145 COSMIC
COSN32201550 3317 COSMIC
COSN19083790 3378 COSMIC
COSN22708914 3388 COSMIC
COSN31849258 3503 COSMIC
COSN8304271 4116 COSMIC
COSN21119633 4576 COSMIC
COSN4870769 4626 COSMIC
COSN30215626 4805 COSMIC
COSN15866715 5598 COSMIC
COSN24864995 5628 COSMIC
COSN22655787 5828 COSMIC
COSN2485019 5859 COSMIC
COSN6886896 5967 COSMIC
COSN32062282 5995 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs750967444 5 dbSNP
rs1342670744 6 dbSNP
rs1230298401 8 dbSNP
rs200914796 10 dbSNP
rs754513957 17 dbSNP
rs781059291 18 dbSNP
rs1363762643 19 dbSNP
rs777270471 21 dbSNP
rs372860080 22 dbSNP
rs756092312 29 dbSNP
rs17290755 36 dbSNP
rs574296031 37 dbSNP
rs183176784 42 dbSNP
rs201214891 43 dbSNP
rs772251838 48 dbSNP
rs775765431 49 dbSNP
rs761254018 51 dbSNP
rs370844927 58 dbSNP
rs577626502 58 dbSNP
rs1260041771 61 dbSNP
rs1338508884 68 dbSNP
rs1222272664 73 dbSNP
rs868394989 74 dbSNP
rs1336653934 75 dbSNP
rs17290762 79 dbSNP
rs201415685 81 dbSNP
rs1252254814 92 dbSNP
rs1030033309 93 dbSNP
rs920921563 95 dbSNP
rs1340770188 97 dbSNP
rs954396966 109 dbSNP
rs562537911 119 dbSNP
rs868589579 120 dbSNP
rs1379999823 122 dbSNP
rs932599269 124 dbSNP
rs533969999 128 dbSNP
rs1043348062 134 dbSNP
rs548092170 135 dbSNP
rs771477460 137 dbSNP
rs17337528 138 dbSNP
rs1052924261 142 dbSNP
rs963554267 146 dbSNP
rs112336528 148 dbSNP
rs1191353722 151 dbSNP
rs1427972468 157 dbSNP
rs1268210285 158 dbSNP
rs1174832746 161 dbSNP
rs892558602 171 dbSNP
rs1469766257 177 dbSNP
rs1270973294 180 dbSNP
rs973186405 181 dbSNP
rs78669011 195 dbSNP
rs527602819 200 dbSNP
rs1224862405 207 dbSNP
rs145703432 215 dbSNP
rs1301368456 219 dbSNP
rs1443681571 222 dbSNP
rs17337535 223 dbSNP
rs1369457090 234 dbSNP
rs187461906 242 dbSNP
rs1373305144 251 dbSNP
rs1399143578 259 dbSNP
rs1002180046 261 dbSNP
rs761660869 272 dbSNP
rs1166353404 282 dbSNP
rs1491117863 282 dbSNP
rs5884404 282 dbSNP
rs796122027 282 dbSNP
rs886062380 282 dbSNP
rs1491469702 283 dbSNP
rs1438175546 285 dbSNP
rs1252487454 286 dbSNP
rs201581453 297 dbSNP
rs959476163 303 dbSNP
rs1256026123 304 dbSNP
rs1027661101 309 dbSNP
rs555208961 317 dbSNP
rs772169130 318 dbSNP
rs1448242676 331 dbSNP
rs886062381 335 dbSNP
rs865960719 339 dbSNP
rs1337893430 340 dbSNP
rs775721438 341 dbSNP
rs1318242911 343 dbSNP
rs1390977468 345 dbSNP
rs1212510693 346 dbSNP
rs949374187 348 dbSNP
rs760485005 349 dbSNP
rs1469425028 350 dbSNP
rs965133565 351 dbSNP
rs1043040229 362 dbSNP
rs976457802 365 dbSNP
rs1365268752 369 dbSNP
rs924188237 378 dbSNP
rs760980020 379 dbSNP
rs764225764 382 dbSNP
rs1436822158 384 dbSNP
rs377284607 392 dbSNP
rs532167841 392 dbSNP
rs1261670283 406 dbSNP
rs1427087149 408 dbSNP
rs1279066544 416 dbSNP
rs1241420062 432 dbSNP
rs1353481050 434 dbSNP
rs1278095878 436 dbSNP
rs920952718 442 dbSNP
rs201854406 448 dbSNP
rs932338699 458 dbSNP
rs1341499584 474 dbSNP
rs900661244 475 dbSNP
rs1042700558 478 dbSNP
rs568552793 486 dbSNP
rs370498791 489 dbSNP
rs1401171303 494 dbSNP
rs1387090752 499 dbSNP
rs1051509624 511 dbSNP
rs1469416152 514 dbSNP
rs934557303 518 dbSNP
rs890123363 523 dbSNP
rs1256121591 524 dbSNP
rs117722337 525 dbSNP
rs1382600753 532 dbSNP
rs895646103 539 dbSNP
rs1384211086 553 dbSNP
rs554077237 554 dbSNP
rs1381852355 558 dbSNP
rs572674550 559 dbSNP
rs192601649 565 dbSNP
rs1316219639 566 dbSNP
rs994699006 574 dbSNP
rs905247850 576 dbSNP
rs958528707 577 dbSNP
rs558159912 578 dbSNP
rs869064669 583 dbSNP
rs1316113495 584 dbSNP
rs1291095037 585 dbSNP
rs1002622880 591 dbSNP
rs1394860645 596 dbSNP
rs1026946422 597 dbSNP
rs953115882 602 dbSNP
rs1004459251 607 dbSNP
rs1015743691 611 dbSNP
rs148966706 613 dbSNP
rs1476102205 615 dbSNP
rs923920472 622 dbSNP
rs762966852 628 dbSNP
rs543922323 629 dbSNP
rs922135655 635 dbSNP
rs55998486 637 dbSNP
rs1334659570 643 dbSNP
rs1273946059 652 dbSNP
rs573672231 654 dbSNP
rs978837793 661 dbSNP
rs1475103120 676 dbSNP
rs925640920 677 dbSNP
rs867800673 678 dbSNP
rs934609860 680 dbSNP
rs372331538 683 dbSNP
rs988734849 689 dbSNP
rs1371668142 693 dbSNP
rs1327621308 707 dbSNP
rs751311059 709 dbSNP
rs529371213 715 dbSNP
rs890185457 717 dbSNP
rs541978485 719 dbSNP
rs1170706973 720 dbSNP
rs3807362 722 dbSNP
rs1005019504 723 dbSNP
rs1044215514 724 dbSNP
rs1455056394 725 dbSNP
rs1255412177 727 dbSNP
rs1192357773 734 dbSNP
rs1468306009 738 dbSNP
rs1233883063 744 dbSNP
rs1158557622 748 dbSNP
rs1206802834 749 dbSNP
rs527564769 758 dbSNP
rs884225 775 dbSNP
rs780864405 776 dbSNP
rs1350195694 777 dbSNP
rs376712694 781 dbSNP
rs894320214 782 dbSNP
rs1366561458 783 dbSNP
rs1298548157 785 dbSNP
rs556198608 812 dbSNP
rs938104924 813 dbSNP
rs1443867806 823 dbSNP
rs1352436598 828 dbSNP
rs1327819918 829 dbSNP
rs1434778975 830 dbSNP
rs185437934 834 dbSNP
rs1048907157 847 dbSNP
rs577672719 849 dbSNP
rs1004894358 861 dbSNP
rs1015817244 867 dbSNP
rs901404939 874 dbSNP
rs1413964941 882 dbSNP
rs1310676354 886 dbSNP
rs549522612 890 dbSNP
rs1486693769 891 dbSNP
rs755795483 892 dbSNP
rs777241924 901 dbSNP
rs1311555978 905 dbSNP
rs1314615836 906 dbSNP
rs1028409907 908 dbSNP
rs1063486 910 dbSNP
rs953970357 915 dbSNP
rs978528819 925 dbSNP
rs1033121797 926 dbSNP
rs886062382 927 dbSNP
rs1376670222 928 dbSNP
rs886062383 934 dbSNP
rs988454507 935 dbSNP
rs1346337105 937 dbSNP
rs1485535046 940 dbSNP
rs1209225493 956 dbSNP
rs1161961485 958 dbSNP
rs917177149 959 dbSNP
rs1407801651 966 dbSNP
rs932154341 966 dbSNP
rs755487141 967 dbSNP
rs979969537 968 dbSNP
rs1483732828 975 dbSNP
rs1255430937 978 dbSNP
rs1210302003 981 dbSNP
rs1176855682 985 dbSNP
rs1486260315 987 dbSNP
rs1261220273 989 dbSNP
rs556908410 993 dbSNP
rs1405800044 1012 dbSNP
rs17337549 1013 dbSNP
rs111347164 1018 dbSNP
rs1380895161 1022 dbSNP
rs1356995942 1031 dbSNP
rs1290859945 1043 dbSNP
rs1394914755 1044 dbSNP
rs1036517767 1049 dbSNP
rs1291129702 1049 dbSNP
rs1048455572 1051 dbSNP
rs771422383 1061 dbSNP
rs554311191 1062 dbSNP
rs41486949 1071 dbSNP
rs1415919979 1072 dbSNP
rs940050115 1081 dbSNP
rs1055651772 1085 dbSNP
rs1264025462 1093 dbSNP
rs954311 1097 dbSNP
rs886062384 1099 dbSNP
rs574310057 1104 dbSNP
rs781572133 1105 dbSNP
rs1185819791 1108 dbSNP
rs998391866 1118 dbSNP
rs1376884493 1123 dbSNP
rs1214130521 1132 dbSNP
rs1336725921 1140 dbSNP
rs1448217250 1147 dbSNP
rs540131976 1148 dbSNP
rs779530410 1149 dbSNP
rs889949986 1154 dbSNP
rs1024171927 1160 dbSNP
rs368494495 1162 dbSNP
rs1000377809 1167 dbSNP
rs372235181 1168 dbSNP
rs576816290 1169 dbSNP
rs1347872046 1174 dbSNP
rs1462688912 1178 dbSNP
rs1232530856 1186 dbSNP
rs958034695 1197 dbSNP
rs1282838738 1201 dbSNP
rs1247306930 1203 dbSNP
rs1194237882 1207 dbSNP
rs1469638210 1214 dbSNP
rs989454659 1220 dbSNP
rs746372291 1225 dbSNP
rs1009906681 1234 dbSNP
rs1252514721 1235 dbSNP
rs112622335 1236 dbSNP
rs141571614 1253 dbSNP
rs535434354 1254 dbSNP
rs1239601128 1260 dbSNP
rs574044240 1265 dbSNP
rs35473039 1280 dbSNP
rs397740131 1280 dbSNP
rs367884402 1299 dbSNP
rs541201884 1300 dbSNP
rs748540519 1305 dbSNP
rs1296707153 1309 dbSNP
rs1429161675 1310 dbSNP
rs927142766 1313 dbSNP
rs920315649 1314 dbSNP
rs951930848 1317 dbSNP
rs985001970 1318 dbSNP
rs1375674105 1323 dbSNP
rs775744651 1326 dbSNP
rs940060846 1331 dbSNP
rs1252208268 1333 dbSNP
rs1202662964 1335 dbSNP
rs1037034484 1336 dbSNP
rs922598976 1346 dbSNP
rs1482441365 1353 dbSNP
rs1280429308 1357 dbSNP
rs1055412180 1358 dbSNP
rs934275353 1359 dbSNP
rs894133658 1360 dbSNP
rs1240165945 1363 dbSNP
rs1337953035 1368 dbSNP
rs1171687800 1373 dbSNP
rs1409513550 1375 dbSNP
rs1426957642 1382 dbSNP
rs760928408 1385 dbSNP
rs546535772 1388 dbSNP
rs150522314 1395 dbSNP
rs1436464543 1399 dbSNP
rs796815853 1402 dbSNP
rs116203092 1420 dbSNP
rs1000385273 1424 dbSNP
rs35700282 1427 dbSNP
rs903021630 1429 dbSNP
rs1365394911 1430 dbSNP
rs41454444 1435 dbSNP
rs769052522 1436 dbSNP
rs1439262000 1437 dbSNP
rs891580042 1446 dbSNP
rs1189478835 1455 dbSNP
rs1473541453 1461 dbSNP
rs1009979930 1477 dbSNP
rs1206299821 1478 dbSNP
rs1306313305 1489 dbSNP
rs1368691926 1491 dbSNP
rs893916239 1498 dbSNP
rs1024005104 1500 dbSNP
rs1356375515 1509 dbSNP
rs971032397 1519 dbSNP
rs1165200715 1520 dbSNP
rs1412991629 1522 dbSNP
rs564000382 1524 dbSNP
rs531507773 1525 dbSNP
rs1001176209 1526 dbSNP
rs1340011096 1529 dbSNP
rs776825406 1530 dbSNP
rs952022012 1531 dbSNP
rs1401225105 1537 dbSNP
rs1309555451 1549 dbSNP
rs984644479 1552 dbSNP
rs762053455 1554 dbSNP
rs1456341220 1570 dbSNP
rs1418080552 1571 dbSNP
rs1189685086 1575 dbSNP
rs766216876 1576 dbSNP
rs1467219463 1581 dbSNP
rs549724089 1584 dbSNP
rs1236456709 1585 dbSNP
rs1194432164 1587 dbSNP
rs972618657 1588 dbSNP
rs961476450 1590 dbSNP
rs139451510 1604 dbSNP
rs774288678 1605 dbSNP
rs920744308 1613 dbSNP
rs1335981257 1616 dbSNP
rs528969997 1617 dbSNP
rs547219627 1634 dbSNP
rs41347952 1635 dbSNP
rs1355652695 1643 dbSNP
rs368218939 1647 dbSNP
rs377500657 1647 dbSNP
rs1431330115 1653 dbSNP
rs886062385 1656 dbSNP
rs934013780 1659 dbSNP
rs1434055822 1660 dbSNP
rs759398265 1660 dbSNP
rs911478266 1669 dbSNP
rs767303455 1672 dbSNP
rs949714398 1674 dbSNP
rs371801373 1681 dbSNP
rs886062386 1690 dbSNP
rs539995759 1691 dbSNP
rs1168025592 1694 dbSNP
rs1476131676 1701 dbSNP
rs891944433 1701 dbSNP
rs1388835254 1702 dbSNP
rs1351017578 1703 dbSNP
rs770091936 1705 dbSNP
rs1188551204 1711 dbSNP
rs373680498 1718 dbSNP
rs1430457138 1720 dbSNP
rs1268849684 1725 dbSNP
rs1219583454 1727 dbSNP
rs1273748224 1728 dbSNP
rs934532621 1731 dbSNP
rs552005129 1734 dbSNP
rs1054316267 1736 dbSNP
rs1010012364 1743 dbSNP
rs1295291109 1749 dbSNP
rs570334434 1751 dbSNP
rs1364543969 1754 dbSNP
rs1327684889 1755 dbSNP
rs752512770 1757 dbSNP
rs1348908149 1758 dbSNP
rs906922745 1761 dbSNP
rs537359645 1764 dbSNP
rs1397171825 1767 dbSNP
rs1329187233 1783 dbSNP
rs755732077 1788 dbSNP
rs1411144998 1796 dbSNP
rs1292930041 1799 dbSNP
rs763803308 1800 dbSNP
rs889129999 1805 dbSNP
rs1168436627 1808 dbSNP
rs187916888 1817 dbSNP
rs1397222516 1823 dbSNP
rs1189876651 1830 dbSNP
rs1477926764 1834 dbSNP
rs1009283413 1838 dbSNP
rs115114373 1846 dbSNP
rs1482111793 1856 dbSNP
rs777979455 1857 dbSNP
rs1291927637 1867 dbSNP
rs887734050 1868 dbSNP
rs1348531620 1873 dbSNP
rs1006547865 1883 dbSNP
rs1014782588 1886 dbSNP
rs1217243508 1901 dbSNP
rs1366722282 1909 dbSNP
rs1279767075 1910 dbSNP
rs375134220 1912 dbSNP
rs1368101280 1925 dbSNP
rs1306901694 1929 dbSNP
rs1435845802 1931 dbSNP
rs975857662 1938 dbSNP
rs1174629178 1940 dbSNP
rs1414246860 1945 dbSNP
rs753331023 1948 dbSNP
rs1027813426 1959 dbSNP
rs1179099995 1960 dbSNP
rs1029718066 1963 dbSNP
rs1471740293 1974 dbSNP
rs761836227 1982 dbSNP
rs57296344 1986 dbSNP
rs558461702 1991 dbSNP
rs553533152 1992 dbSNP
rs573391801 1996 dbSNP
rs1208020433 1997 dbSNP
rs1311326654 1998 dbSNP
rs1284711904 2001 dbSNP
rs971102532 2007 dbSNP
rs1416785687 2031 dbSNP
rs536514360 2032 dbSNP
rs911213192 2033 dbSNP
rs756732299 2046 dbSNP
rs924284879 2052 dbSNP
rs778287459 2054 dbSNP
rs1400578468 2064 dbSNP
rs746342816 2068 dbSNP
rs946216230 2073 dbSNP
rs17290771 2077 dbSNP
rs906958961 2090 dbSNP
rs937065664 2093 dbSNP
rs914409223 2095 dbSNP
rs932437629 2102 dbSNP
rs545527430 2110 dbSNP
rs1312466464 2112 dbSNP
rs889175181 2126 dbSNP
rs1055503673 2133 dbSNP
rs887421505 2135 dbSNP
rs1006164199 2143 dbSNP
rs1353872783 2152 dbSNP
rs897818502 2157 dbSNP
rs112723392 2158 dbSNP
rs1284792785 2159 dbSNP
rs897721139 2161 dbSNP
rs1309969968 2164 dbSNP
rs1395905998 2168 dbSNP
rs1350047055 2169 dbSNP
rs1027824800 2172 dbSNP
rs884904 2173 dbSNP
rs1388450699 2174 dbSNP
rs1326752182 2175 dbSNP
rs563963496 2182 dbSNP
rs1459655252 2183 dbSNP
rs1030116383 2191 dbSNP
rs41399446 2202 dbSNP
rs985932184 2209 dbSNP
rs543388808 2214 dbSNP
rs957615754 2216 dbSNP
rs1256364435 2218 dbSNP
rs1420119491 2219 dbSNP
rs3088198 2223 dbSNP
rs1190492296 2228 dbSNP
rs1463370933 2237 dbSNP
rs1247184707 2238 dbSNP
rs1213862494 2239 dbSNP
rs1489269846 2254 dbSNP
rs1484519834 2255 dbSNP
rs990144726 2258 dbSNP
rs981204594 2267 dbSNP
rs1300443078 2269 dbSNP
rs1226845509 2282 dbSNP
rs913489036 2287 dbSNP
rs946247204 2288 dbSNP
rs774470715 2290 dbSNP
rs955692645 2291 dbSNP
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rs1041302159 5915 dbSNP
rs949156862 5916 dbSNP
rs568755098 5918 dbSNP
rs553731234 5924 dbSNP
rs1387773087 5925 dbSNP
rs1296890302 5929 dbSNP
rs1358403073 5934 dbSNP
rs899652070 5945 dbSNP
rs764486818 5948 dbSNP
rs1000516005 5950 dbSNP
rs1368164881 5950 dbSNP
rs1193980951 5952 dbSNP
rs1050520053 5954 dbSNP
rs754261875 5956 dbSNP
rs536194477 5959 dbSNP
rs1357973 5971 dbSNP
rs748901449 5974 dbSNP
rs1214381450 5976 dbSNP
rs71714368 5980 dbSNP
rs10644261 5981 dbSNP
rs3065295 5981 dbSNP
rs746933682 5981 dbSNP
rs761978864 5981 dbSNP
rs1211463236 5989 dbSNP
rs1353800621 5990 dbSNP
rs1283305636 5997 dbSNP
rs1285679879 6002 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions PC3 , DU145
Disease 1956.0
Location of target site 3'UTR
Original Description (Extracted from the article) ... "EGFR was significantly lowered in both DU145 and PC3 cell lines 72 h after transfection of miR-133a/b ...

- Tao J; Wu D; Xu B; Qian W; Li P; Lu Q; Yin et al., 2012, Oncology reports.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gucgaccaacuuccCCUGGUUu 5'
                        ||||||| 
Target 5' -----ucagcauuuGGACCAAu 3'
 		1 - 17
Article - Tao J; Wu D; Xu B; Qian W; Li P; Lu Q; Yin et al.
- Oncology reports, 2012
It has been shown that regulation of EGFR expression in prostate cancer cells is mostly at the transcriptional level. microRNA-133 (miR-133) has long been recognized as a muscle-specific miRNA which may regulate myoblast differentiation and participate in many myogenic diseases. Recently, it has been reported that miR-133 is also involved in other tumors, such as bladder cancer, esophageal cancer and may regulate cell motility in these cancer cells. In the present study, we examined the expression and effects of miR-133 in two hormone-insensitive prostate cancer cell lines. The expression of miR-133a and miR-133b were analyzed by quantitative RT-PCR. After transfection of miR-133a and miR-133b, cell viability assay, luciferase assay, western blot analysis, cell migration and invasion assay were conducted in Du145 and PC3 cells. In this study, we showed that miR133a and miR-133b are expressed at the detection limit in two hormone-insensitive prostate cancer cell lines, PC3 and DU145. Ectopic expression of miR-133 inhibited cell proliferation, migration and invasion in these cells. We also provide the first evidence that miR-133 may target EGFR. Our study provided the first glimpse of the functional role of miR-133 in two hormone-independent prostate cancer cell lines. These results may add to our knowledge on the molecular basis of prostate cancer progression.
LinkOut: [PMID: 22407299]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Disease 1956.0
Location of target site 3'UTR
Tools used in this research TargetScan
Original Description (Extracted from the article) ... "the EGFR is a target of miR-133a ...

- Lee SY; Ham O; Cha MJ; Song BW; Choi E; Kim et al., 2013, Biomaterials.

Article - Lee SY; Ham O; Cha MJ; Song BW; Choi E; Kim et al.
- Biomaterials, 2013
Human bone marrow-derived mesenchymal stem cells (hMSCs) are an attractive candidate for cell therapy in heart disease. Low survival and incomplete electromechanical integration between resident cardiomyocytes and transplanted hMSCs remain unsolved. In order for an infarcted heart to tolerate transplantation, differentiation capacity in stem cells must be reinforced. In this study, we found that compound 56, an epidermal growth factor receptor (EGFR) inhibitor, promotes cardiogenic differentiation of hMSCs and the transplantation of hMSCs treated with compound 56 resulted in enhancement of heart functions. Furthermore, hMSCs transfected with microRNA-133a (miR-133a), which targets EGFR, were observed to express cardiac-specific markers. We also discovered that luciferase activity is exclusively decreased by targeting EGFR in hMSCs transfected with miR-133a mimic. These results suggest that EGFR plays a key role in the regulation of cardiogenic differentiation in hMSCs.
LinkOut: [PMID: 23069713]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HBL-100 , MCF-7
Location of target site 3'UTR
Tools used in this research DIANA-microT , TargetScan
Original Description (Extracted from the article) ... These data manifest that the miR-133a functions by directly targeting to the 3芒鈧鈩UTR of EGFR. ...

- Cui W; Zhang S; Shan C; Zhou L; Zhou Z, 2013, The FEBS journal.

Article - Cui W; Zhang S; Shan C; Zhou L; Zhou Z
- The FEBS journal, 2013
microRNAs are small, highly conserved, non-coding RNAs that regulate gene expression of target mRNAs through cleavage or translational inhibition, and are widely involved in carcinogenesis and cancer development. In this study, the expression profile of microRNA-133a (miR-133a) was examined in breast cancer cells and breast cancer tissues. The results showed that expression of miR-133a in both breast cancer cells and breast cancer tissues was significantly down-regulated. Over-expression of miR-133a in tumor cells arrested the cell cycle by drastically decreasing the G2 /S phase and retarded the newly synthesized DNA, suggesting a regulatory role for miR-133a in proliferation of breast cancer cells. Bioinformatics prediction showed that epidermal growth factor receptor (EGFR) is a potential target for miR-133a. A dual luciferase reporter gene assay showed that miR-133a bound to the 3' UTR of EGFR but not a mutated 3' UTR, thereby down-regulating the protein expression level. Accordingly, we found that expression of EGFR protein decreased with increased expression of miR-133a in MCF-7 and MDA-MB-231 cells. Over-expression of miR-133a in breast cancer cells resulted in suppression of the level of phosphorylated Akt protein (p-Akt) and inhibition of p-Akt nuclear translocation. These results demonstrate that miR-133a, which may act as a tumor suppressor in breast cancer, regulates the cell cycle and proliferation in tumorigenesis by targeting EGFR through the downstream signal molecule Akt. Overall, these results show that miR-133a may be used as biomarker and/or therapeutic target for diagnosis and therapy of breast cancer.
LinkOut: [PMID: 23786162]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions A549 , H1299
Disease non-small cell lung carcinoma
Location of target site 3'UTR
Original Description (Extracted from the article) ... MiR133a is downregulated in malignant lung cancer cells and inhibits the cell invasive capacity ...

- Wang LK; Hsiao TH; Hong TM; Chen HY; Kao et al., 2014, PloS one.

Article - Wang LK; Hsiao TH; Hong TM; Chen HY; Kao et al.
- PloS one, 2014
Non-small cell lung cancers (NSCLCs) cause high mortality worldwide, and the cancer progression can be activated by several genetic events causing receptor dysregulation, including mutation or amplification. MicroRNAs are a group of small non-coding RNA molecules that function in gene silencing and have emerged as the fine-tuning regulators during cancer progression. MiR-133a is known as a key regulator in skeletal and cardiac myogenesis, and it acts as a tumor suppressor in various cancers. This study demonstrates that miR-133a expression negatively correlates with cell invasiveness in both transformed normal bronchial epithelial cells and lung cancer cell lines. The oncogenic receptors in lung cancer cells, including insulin-like growth factor 1 receptor (IGF-1R), TGF-beta receptor type-1 (TGFBR1), and epidermal growth factor receptor (EGFR), are direct targets of miR-133a. MiR-133a can inhibit cell invasiveness and cell growth through suppressing the expressions of IGF-1R, TGFBR1 and EGFR, which then influences the downstream signaling in lung cancer cell lines. The cell invasive ability is suppressed in IGF-1R- and TGFBR1-repressed cells and this phenomenon is mediated through AKT signaling in highly invasive cell lines. In addition, by using the in vivo animal model, we find that ectopically-expressing miR-133a dramatically suppresses the metastatic ability of lung cancer cells. Accordingly, patients with NSCLCs who have higher expression levels of miR-133a have longer survival rates compared with those who have lower miR-133a expression levels. In summary, we identified the tumor suppressor role of miR-133a in lung cancer outcome prognosis, and we demonstrated that it targets several membrane receptors, which generally produce an activating signaling network during the progression of lung cancer.
LinkOut: [PMID: 24816813]
Experimental Support 5 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Disease cervical cancer
Location of target site 3'UTR
Tools used in this research miRanda , TargetScan
Original Description (Extracted from the article) ... The epidermal growth factor receptor (EGFR) was confirmed to be a direct target of miR-133a in cervical cancer cells using luciferase assay and western blotting ...

- Song X; Shi B; Huang K; Zhang W, 2015, Oncology reports.

Article - Song X; Shi B; Huang K; Zhang W
- Oncology reports, 2015
MicroRNAs (miRNAs) are small non-coding RNAs that play critical roles in cervical carcinogenesis and progression. microRNA-133a (miR-133a) has been reported to play a tumor-suppressor role in a range of cancers. However, the role and underlying molecular mechanism of miR-133a in cervical cancer have not been investigated. In the present study, we investigated the role of miR-133a in the tumorigenicity of cervical cancer cells in vivo and in vitro. The expression of miR-133a was investigated using real-time reverse transcription-polymerase chain reaction (qRT-PCR) in 30 cervical specimens and matched adjacent normal tissues and cervical cancer cell lines. We found that the expression level of miR133a was significantly downregulated in cervical cancer tissues and cervical cancer cell lines, and the aberrant expression of miR-133a was correlated with lymph node metastasis, histological grade and FIGO stage. The role of miR-133a in tumorigenicity of cervical cancer cells was assessed by the restoration of miR-133a. We found that restoration of miR133a inhibited cell proliferation, colony formation, migration and invasion, promoted cell apoptosis in vitro and suppressed tumorigenicity in vivo. The epidermal growth factor receptor (EGFR) was confirmed to be a direct target of miR-133a in cervical cancer cells using luciferase assay and western blotting. Restoration of miR-133a inhibited EGFR expression and activated the AKT and ERK signaling pathways. These results showed that miR-133a suppresses cervical cancer growth in vitro and in vivo through targeting EGFR, suggesting that miR-133a can be a potential target for the treatment of cervical cancer.
LinkOut: [PMID: 26134491]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
STAD 0.548 0 0.698 0 32 Click to see details
KIRC -0.287 0.01 -0.290 0.01 67 Click to see details
KICH 0.402 0.03 0.380 0.03 24 Click to see details
UCEC -0.37 0.06 -0.133 0.29 19 Click to see details
LUAD -0.455 0.07 -0.364 0.12 12 Click to see details
THCA 0.143 0.14 0.162 0.11 59 Click to see details
PAAD -0.476 0.26 -0.200 0.4 4 Click to see details
CHOL -0.184 0.32 -0.433 0.12 9 Click to see details
PRAD -0.061 0.34 -0.027 0.43 50 Click to see details
LIHC -0.059 0.34 0.028 0.42 49 Click to see details
KIRP 0.076 0.34 0.070 0.36 30 Click to see details
ESCA -0.09 0.4 0.127 0.35 11 Click to see details
BRCA 0.023 0.42 0.112 0.17 77 Click to see details
BLCA -0.024 0.46 -0.015 0.48 18 Click to see details
PCPG 0.094 0.47 0.500 0.33 3 Click to see details
CESC 0.086 0.47 0.500 0.33 3 Click to see details
COAD 0.025 0.48 0.048 0.46 8 Click to see details
HNSC 0.004 0.49 -0.077 0.31 42 Click to see details
LUSC -0.001 0.5 -0.057 0.37 38 Click to see details
LUSC -0.001 0.5 -0.057 0.37 38 Click to see details
LUSC -0.001 0.5 -0.057 0.37 38 Click to see details
122 hsa-miR-133a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000325 RHOA ras homolog family member A 1 2
MIRT000327 CDC42 cell division cycle 42 4 2
MIRT000328 ERG ERG, ETS transcription factor 1 1
MIRT000329 HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2 1
MIRT000330 UCP2 uncoupling protein 2 2 2
MIRT000331 KRT7 keratin 7 2 2
MIRT001203 CACNA1C calcium voltage-gated channel subunit alpha1 C 3 1
MIRT001204 HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 4 2
MIRT001816 PKM pyruvate kinase, muscle 1 1
MIRT001986 CASP9 caspase 9 3 3
MIRT002925 KCNQ1 potassium voltage-gated channel subfamily Q member 1 4 1
MIRT003542 FSCN1 fascin actin-bundling protein 1 5 4
MIRT004831 KCNH2 potassium voltage-gated channel subfamily H member 2 4 1
MIRT005604 TAGLN2 transgelin 2 5 4
MIRT005813 LASP1 LIM and SH3 protein 1 3 2
MIRT006571 PNP purine nucleoside phosphorylase 4 2
MIRT006680 MSN moesin 2 1
MIRT007032 EGFR epidermal growth factor receptor 3 5
MIRT007088 VKORC1 vitamin K epoxide reductase complex subunit 1 1 1
MIRT007383 PRDM16 PR/SET domain 16 1 2
MIRT021693 TPM1 tropomyosin 1 1 1
MIRT021695 FBN1 fibrillin 1 1 1
MIRT021696 FAM120C family with sequence similarity 120C 1 1
MIRT021697 BCAN brevican 1 1
MIRT021698 TCTEX1D2 Tctex1 domain containing 2 1 1
MIRT021699 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 1 1
MIRT021700 RFT1 RFT1 homolog 1 1
MIRT021701 SENP1 SUMO1/sentrin specific peptidase 1 1 1
MIRT021702 SMIM14 small integral membrane protein 14 1 1
MIRT021703 PRELID1 PRELI domain containing 1 1 1
MIRT021704 CNN2 calponin 2 3 3
MIRT021705 ARPC5 actin related protein 2/3 complex subunit 5 4 2
MIRT021706 FTL ferritin light chain 2 2
MIRT021707 CERS2 ceramide synthase 2 1 1
MIRT021708 SEC61B Sec61 translocon beta subunit 1 1
MIRT021709 PLEKHA3 pleckstrin homology domain containing A3 1 1
MIRT021710 EGFL7 EGF like domain multiple 7 1 1
MIRT021711 VEGFA vascular endothelial growth factor A 1 1
MIRT021712 PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 1 1
MIRT021713 RGS3 regulator of G protein signaling 3 1 1
MIRT021714 COL1A1 collagen type I alpha 1 chain 4 1
MIRT021715 GSTP1 glutathione S-transferase pi 1 2 1
MIRT035537 SP1 Sp1 transcription factor 2 2
MIRT035579 KLF15 Kruppel like factor 15 1 1
MIRT045837 NR4A2 nuclear receptor subfamily 4 group A member 2 1 1
MIRT052647 BCL2L1 BCL2 like 1 4 2
MIRT052648 MCL1 MCL1, BCL2 family apoptosis regulator 4 2
MIRT053333 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 4 1
MIRT054310 IGF1R insulin like growth factor 1 receptor 3 2
MIRT055599 FAM160B1 family with sequence similarity 160 member B1 2 2
MIRT081957 UBA2 ubiquitin like modifier activating enzyme 2 4 1
MIRT437400 MMP14 matrix metallopeptidase 14 3 1
MIRT437953 ANXA2 annexin A2 4 1
MIRT437954 SNX30 sorting nexin family member 30 4 1
MIRT437955 SGMS2 sphingomyelin synthase 2 4 1
MIRT438719 PDLIM5 PDZ and LIM domain 5 3 1
MIRT452802 PACS2 phosphofurin acidic cluster sorting protein 2 2 2
MIRT462823 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT468494 SESN2 sestrin 2 2 2
MIRT477714 EFHD2 EF-hand domain family member D2 2 2
MIRT483852 EMID1 EMI domain containing 1 2 2
MIRT490039 PRRT2 proline rich transmembrane protein 2 2 2
MIRT491349 CDKN1A cyclin dependent kinase inhibitor 1A 2 4
MIRT504443 MC2R melanocortin 2 receptor 2 2
MIRT505701 SESN3 sestrin 3 2 2
MIRT513521 RHOQ ras homolog family member Q 2 4
MIRT517423 HIST2H2AC histone cluster 2 H2A family member c 2 2
MIRT526599 DCAKD dephospho-CoA kinase domain containing 2 2
MIRT528904 THBS2 thrombospondin 2 2 2
MIRT533060 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT534126 SNX33 sorting nexin 33 2 2
MIRT534700 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 4
MIRT535732 MYPN myopalladin 2 2
MIRT538529 CHMP3 charged multivesicular body protein 3 2 4
MIRT550878 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT551260 PSMG1 proteasome assembly chaperone 1 2 2
MIRT551981 UGT2B10 UDP glucuronosyltransferase family 2 member B10 2 2
MIRT553866 SYAP1 synapse associated protein 1 2 2
MIRT558810 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 2
MIRT559367 ATP13A3 ATPase 13A3 2 2
MIRT560941 ZFP28 ZFP28 zinc finger protein 2 2
MIRT565461 SUPT16H SPT16 homolog, facilitates chromatin remodeling subunit 2 2
MIRT566234 PTMA prothymosin, alpha 2 2
MIRT568217 C11orf24 chromosome 11 open reading frame 24 2 2
MIRT608912 NCDN neurochondrin 2 6
MIRT613229 CCDC39 coiled-coil domain containing 39 2 2
MIRT623563 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT637224 TMEM59 transmembrane protein 59 2 2
MIRT641669 CCNI cyclin I 2 2
MIRT644440 ALDOC aldolase, fructose-bisphosphate C 2 2
MIRT644755 TXNRD3NB thioredoxin reductase 3 neighbor 2 2
MIRT646711 PDE1A phosphodiesterase 1A 2 2
MIRT647577 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT647760 RNF168 ring finger protein 168 2 2
MIRT649267 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT651238 ZMAT4 zinc finger matrin-type 4 2 2
MIRT652146 TRIM71 tripartite motif containing 71 2 2
MIRT657168 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT668302 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT687546 MLEC malectin 2 2
MIRT690857 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT697060 PSMC4 proteasome 26S subunit, ATPase 4 2 2
MIRT699725 SERPINH1 serpin family H member 1 2 2
MIRT700858 PER2 period circadian clock 2 2 2
MIRT705068 C4orf29 abhydrolase domain containing 18 2 2
MIRT709496 ANGPT4 angiopoietin 4 2 2
MIRT713925 PIGR polymeric immunoglobulin receptor 2 2
MIRT716058 SFTPB surfactant protein B 2 2
MIRT716724 APOL6 apolipoprotein L6 2 2
MIRT721677 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT723379 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT731340 IGF1 insulin like growth factor 1 1 1
MIRT731591 ZEB1 zinc finger E-box binding homeobox 1 1 1
MIRT732526 PTBP1 polypyrimidine tract binding protein 1 2 0
MIRT732527 KDM5C lysine demethylase 5C 2 0
MIRT732589 BCL2 BCL2, apoptosis regulator 2 0
MIRT732590 CASP3 caspase 3 2 0
MIRT733594 PPP2CA protein phosphatase 2 catalytic subunit alpha 3 0
MIRT735355 MB myoglobin 1 0
MIRT735744 CDCA8 cell division cycle associated 8 3 0
MIRT736984 SET SET nuclear proto-oncogene 1 0
MIRT737550 TGFB1 transforming growth factor beta 1 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-133a Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-133a Proanthocyanin NULL 108065 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-133a Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-133a Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-133a Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miR-133a Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miR-133a Benzene NULL 241 MiRNA PCR array white blood cell 24780745 2014 down-regulated
miR-133a Benzene NULL 241 MiRNA PCR array blood mononuclear cells 24780745 2014 down-regulated
miR-133a Ibandronate approved 60852 Quantitative real-time PCR Periodontal ligament stem cells (PDLSCs) 21108928 2011 down-regulated
miR-133a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-133a Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-133a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 down-regulated
miR-133a Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-133a Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-133a 5-Fluorouracil approved 3385 Quantitative real-time PCR colon cancer cells 17702597 2007 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H358, H1993)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H1155, H358, H1993)
hsa-miR-133a-3p Sunitinib 5329102 NSC750690 approved resistant High Metastatic Renal Cell Carcinoma tissue and cell line (Caki-2)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant Low Esophageal Squamous Cell Carcinoma tissue
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Head And Neck Squamous Cell Carcinoma cell line (Hep-2, NP69)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer tissue
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Urothelial Bladder Cancer cell line (T24)
hsa-miR-133a-3p Gemcitabine 60750 NSC613327 approved sensitive Low Urothelial Bladder Cancer cell line (T24)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant Low Prostate Cancer cell line (PC-3-R)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved sensitive Low Nasopharyngeal Cancer cell line (HONE1, SUNE1)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer cell line (MGC-803)
hsa-miR-133a-3p Bromocriptine 31101 NSC169774 approved resistant Low Prolactinoma tissue
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-133a-3p Gefitinib 123631 NSC715055 approved sensitive Low Non-Small Cell Lung Cancer cell line (PC-9)
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Etoposide 36462 NSC141540 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Vinorelbine 44424639 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Vincristine 5978 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (SKOV3, A2780)
hsa-miR-133a-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-133a-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-133a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-133a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-133a-3p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-133a-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-133a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-133a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine sensitive cell line (Bats-72)

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