miRTarBase - #MIRT007068


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pre-miRNA Information
pre-miRNA hsa-mir-137   
Genomic Coordinates chr1: 98046070 - 98046171
Description Homo sapiens miR-137 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-137
Sequence 59| UUAUUGCUUAAGAAUACGCGUAG |81
Evidence Experimental
Experiments Cloned
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B41RDC miR-137 Safety Biomarker (SAF) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol ZNF804A   
Synonyms C2orf10
Description zinc finger protein 804A
Transcript NM_194250   
Expression
Putative miRNA Targets on ZNF804A
3'UTR of ZNF804A
(miRNA target sites are highlighted)		 
>ZNF804A|NM_194250|3'UTR
   1 TCATCACCATAATGGGAAAAAAATACTCTTGTGAAAACTATTGCTATATGCGTTAAGTGTTCATCTATGTGGGTACATGG
  81 CTATTTAACTGGTGGAAATAAACTGGCCGATACATGGCGTCATTGGTTTGAAATCATTTACTGTAAGTGCAATGATGCAA
 161 ATAAATCCCTAAGTTTCTGATATATAATATTATTAAAGCACTGAATAGTTTGAAAATCAATACAATATATGCTATATATT
 241 AAAATGATGTCTTAAGAGTATGTATAATGTACATAAAATATATTTATAGTACTCTAATTTATGTTGTAAAGTATGCTCCC
 321 TTGGTTTTTCTTAATCTTTGTGTATTTGCACCTATTTAATGTTTAGACAAAGCTGATGGCACTATGTTTTGTATCATGTT
 401 CCTTGAAACTGTAAATTCAGTGAAAAATATCTCTTGCAATAAATTTTTGTTAACTATTTAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaugcgcAUA-AGAAUUCGUUAUu 5'
                 ||| ||||  |||||| 
Target 5' tgaaaaaTATCTCTT--GCAATAa 3'
 421 - 442 131.00 -6.60
2 
miRNA  3' gaugcgcauaagaauuCGUUAUu 5'
                          |||||: 
Target 5' atcatttactgtaagtGCAATGa 3'
 133 - 155 104.00 -6.60
3 
miRNA  3' gaugcgcaUA-AGAAUUCGUUAUu 5'
                  || ||||||| |:|| 
Target 5' ttaaaatgATGTCTTAAG-AGTAt 3'
 239 - 261 99.00 -8.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN27006579 2 COSMIC
COSN31504589 3 COSMIC
COSN32074137 5 COSMIC
COSN31500310 9 COSMIC
COSN30186202 10 COSMIC
COSN13956495 17 COSMIC
COSN27006581 18 COSMIC
COSN31500461 21 COSMIC
COSN27006578 24 COSMIC
COSN28851952 24 COSMIC
COSN31587537 27 COSMIC
COSN30151511 29 COSMIC
COSN2534016 40 COSMIC
COSN30517631 47 COSMIC
COSN28709691 52 COSMIC
COSN30139044 52 COSMIC
COSN30148847 53 COSMIC
COSN15315299 54 COSMIC
COSN166349 59 COSMIC
COSN19705252 66 COSMIC
COSN30119481 86 COSMIC
COSN31596054 87 COSMIC
COSN30483850 88 COSMIC
COSN30458395 90 COSMIC
COSN30107561 95 COSMIC
COSN30519172 95 COSMIC
COSN30491651 96 COSMIC
COSN31516132 100 COSMIC
COSN13956498 110 COSMIC
COSN30657878 120 COSMIC
COSN30136771 121 COSMIC
COSN30179669 126 COSMIC
COSN30524558 127 COSMIC
COSN30178504 129 COSMIC
COSN31574534 136 COSMIC
COSN30521566 156 COSMIC
COSN31586081 158 COSMIC
COSN31483716 173 COSMIC
COSN8608193 200 COSMIC
COSN30126346 222 COSMIC
COSN30170825 231 COSMIC
COSN31585821 331 COSMIC
COSN31486953 349 COSMIC
COSN30174995 440 COSMIC
COSN31609940 447 COSMIC
COSN17078165 458 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs370441814 1 dbSNP
rs770847397 5 dbSNP
rs1453258532 6 dbSNP
rs1226488800 8 dbSNP
rs774203029 9 dbSNP
rs1267942282 11 dbSNP
rs202029440 12 dbSNP
rs771615651 13 dbSNP
rs142431760 14 dbSNP
rs1171704644 15 dbSNP
rs1032230441 17 dbSNP
rs747215976 17 dbSNP
rs780160258 17 dbSNP
rs762401201 20 dbSNP
rs1449823162 23 dbSNP
rs373072311 29 dbSNP
rs768659748 29 dbSNP
rs931131419 30 dbSNP
rs750909266 31 dbSNP
rs1391462083 32 dbSNP
rs1407337037 34 dbSNP
rs763371442 39 dbSNP
rs766675028 42 dbSNP
rs1400962351 46 dbSNP
rs751786999 47 dbSNP
rs377185111 48 dbSNP
rs1226152877 49 dbSNP
rs370374059 52 dbSNP
rs777640485 53 dbSNP
rs77067231 54 dbSNP
rs879150486 57 dbSNP
rs192818983 59 dbSNP
rs1189436699 64 dbSNP
rs981587843 65 dbSNP
rs1466361034 68 dbSNP
rs555154291 73 dbSNP
rs1271692858 76 dbSNP
rs1316233313 85 dbSNP
rs570102875 92 dbSNP
rs879920058 107 dbSNP
rs185740197 109 dbSNP
rs984943037 110 dbSNP
rs757087016 114 dbSNP
rs1278894310 116 dbSNP
rs1314011866 119 dbSNP
rs901806712 120 dbSNP
rs145975390 124 dbSNP
rs1317898685 133 dbSNP
rs943664050 138 dbSNP
rs1351016496 146 dbSNP
rs190269692 153 dbSNP
rs974807809 155 dbSNP
rs1167498542 163 dbSNP
rs1404006815 165 dbSNP
rs544604114 174 dbSNP
rs1213808152 176 dbSNP
rs1284767765 179 dbSNP
rs893316939 184 dbSNP
rs1451494142 188 dbSNP
rs1194578084 192 dbSNP
rs1244143993 194 dbSNP
rs1477248579 197 dbSNP
rs1011738265 202 dbSNP
rs932986214 206 dbSNP
rs1395910622 214 dbSNP
rs1455798738 217 dbSNP
rs1156901303 219 dbSNP
rs1290686974 223 dbSNP
rs1228712316 231 dbSNP
rs1343806467 233 dbSNP
rs1294905884 236 dbSNP
rs1360039768 237 dbSNP
rs1381206524 246 dbSNP
rs551480596 247 dbSNP
rs1426354551 252 dbSNP
rs1434852546 255 dbSNP
rs1365350374 257 dbSNP
rs1320240430 264 dbSNP
rs1347832971 270 dbSNP
rs967116194 280 dbSNP
rs775610737 284 dbSNP
rs1435511428 287 dbSNP
rs1275278127 294 dbSNP
rs1433914943 295 dbSNP
rs1372720198 307 dbSNP
rs1192865700 312 dbSNP
rs1267958367 313 dbSNP
rs1237559504 316 dbSNP
rs902275202 317 dbSNP
rs936462960 318 dbSNP
rs1483900878 322 dbSNP
rs762986155 323 dbSNP
rs1226230787 325 dbSNP
rs1312267653 331 dbSNP
rs1302683809 337 dbSNP
rs895041186 345 dbSNP
rs1035777342 372 dbSNP
rs1012199010 374 dbSNP
rs1309154473 380 dbSNP
rs1412131791 382 dbSNP
rs1369094873 385 dbSNP
rs1297827865 388 dbSNP
rs756152082 393 dbSNP
rs1379469230 396 dbSNP
rs907162686 399 dbSNP
rs1428573169 410 dbSNP
rs1003293317 411 dbSNP
rs1473488340 430 dbSNP
rs1433357885 435 dbSNP
rs570035745 438 dbSNP
rs1373024708 445 dbSNP
rs1249258102 447 dbSNP
rs931183406 450 dbSNP
rs982579095 455 dbSNP
rs908346229 460 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Be2C , HEK293
Location of target site 3'UTR
Tools used in this research miRecord , PITA
Original Description (Extracted from the article) ... "Here ...

- Kim AH; Parker EK; Williamson V; McMichael et al., 2012, Schizophrenia research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaugcgcAUA-AGAAUUCGUUAUu 5'
                 ||| ||||  |||||| 
Target 5' ugaaaaaUAUCUCUU--GCAAUAa 3'
 		2 - 23
Article - Kim AH; Parker EK; Williamson V; McMichael et al.
- Schizophrenia research, 2012
MicroRNAs (miRNAs) are small non-coding RNAs that mainly function as negative regulators of gene expression (Lai, 2002) and have been shown to be involved in schizophrenia etiology through genetic and expression studies (Burmistrova et al., 2007; Hansen et al., 2007a; Perkins et al., 2007; Beveridge et al., 2010; Kim et al., 2010). In a mega analysis of genome-wide association study (GWAS) of schizophrenia (SZ) and bipolar disorders (BP), a polymorphism (rs1625579) located in the primary transcript of a miRNA gene, hsa-miR-137, was reported to be strongly associated with SZ. Four SZ loci (CACNA1C, TCF4, CSMD1, C10orf26) achieving genome-wide significance in the same study were predicted and later experimentally validated (Kwon et al., 2011) as hsa-miR-137 targets. Here, using in silico, cellular and luciferase based approaches we also provide evidence that another well replicated candidate schizophrenia gene, ZNF804A, is also target for hsa-miR-137.
LinkOut: [PMID: 22883350]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21687 Ependynoma primary tumors 0.456 7.6e-5 0.413 3.5e-4 64 Click to see details
GSE28260 Renal cortex and medulla -0.808 4.2e-4 -0.736 2.1e-3 13 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.364 3.7e-2 -0.308 6.7e-2 25 Click to see details
GSE28544 Breast cancer -0.307 7.2e-2 -0.244 1.3e-1 24 Click to see details
GSE21849 B cell lymphoma -0.252 9.4e-2 -0.082 3.4e-1 29 Click to see details
GSE32688 Pancreatic cancer -0.118 2.6e-1 0.162 1.9e-1 32 Click to see details
GSE38226 Liver fibrosis 0.145 2.7e-1 0.463 1.7e-2 21 Click to see details
GSE19350 CNS germ cell tumors 0.17 3.0e-1 0.458 6.7e-2 12 Click to see details
GSE17498 Multiple myeloma 0.043 4.0e-1 -0.049 3.8e-1 40 Click to see details
GSE14794 Lymphoblastoid cells 0.023 4.1e-1 0.052 3.1e-1 90 Click to see details
GSE27834 Pluripotent stem cells 0.045 4.3e-1 -0.271 1.5e-1 16 Click to see details
GSE26953 Aortic valvular endothelial cells 0.033 4.4e-1 0.189 1.9e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.018 4.7e-1 0.161 2.5e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.018 4.7e-1 0.161 2.5e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.018 4.7e-1 0.161 2.5e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.018 4.7e-1 0.161 2.5e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC -0.994 0 -0.800 0.1 4 Click to see details
CHOL 0.988 0.01 0.400 0.3 4 Click to see details
KICH 0.835 0.08 1.000 0.5 4 Click to see details
PCPG 0.912 0.13 1.000 0.5 3 Click to see details
KIRP -0.43 0.14 -0.357 0.19 8 Click to see details
LIHC -0.862 0.17 -1.000 0.5 3 Click to see details
BLCA 0.623 0.19 0.800 0.1 4 Click to see details
PAAD 0.48 0.26 0.400 0.3 4 Click to see details
HNSC -0.111 0.28 -0.064 0.37 29 Click to see details
ESCA -0.281 0.36 0.000 0.5 4 Click to see details
THCA 0.067 0.37 -0.010 0.48 27 Click to see details
PRAD -0.064 0.38 0.014 0.47 24 Click to see details
LUSC 0.118 0.4 0.071 0.44 7 Click to see details
STAD 0.007 0.49 -0.115 0.35 13 Click to see details
BRCA -0.011 0.49 0.200 0.35 6 Click to see details
BRCA -0.011 0.49 0.200 0.35 6 Click to see details
BRCA -0.011 0.49 0.200 0.35 6 Click to see details
BRCA -0.011 0.49 0.200 0.35 6 Click to see details
140 hsa-miR-137 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT002489 E2F6 E2F transcription factor 6 4 1
MIRT002490 CDK6 cyclin dependent kinase 6 4 7
MIRT004004 NCOA2 nuclear receptor coactivator 2 4 1
MIRT004579 KDM1A lysine demethylase 1A 5 3
MIRT005485 CDC42 cell division cycle 42 4 4
MIRT005605 CTBP1 C-terminal binding protein 1 4 1
MIRT005883 MITF melanogenesis associated transcription factor 3 1
MIRT006329 PTGS2 prostaglandin-endoperoxide synthase 2 2 1
MIRT006957 ESRRA estrogen related receptor alpha 1 1
MIRT007068 ZNF804A zinc finger protein 804A 1 1
MIRT007092 YBX1 Y-box binding protein 1 3 3
MIRT007252 CSE1L chromosome segregation 1 like 2 1
MIRT007346 PXN paxillin 3 1
MIRT053056 GLIPR1 GLI pathogenesis related 1 3 1
MIRT053225 MET MET proto-oncogene, receptor tyrosine kinase 3 1
MIRT054547 FUNDC1 FUN14 domain containing 1 3 1
MIRT054568 BNIP3L BCL2 interacting protein 3 like 3 1
MIRT090615 PLS1 plastin 1 2 2
MIRT093393 TMA16 translation machinery associated 16 homolog 2 2
MIRT109230 VMA21 VMA21, vacuolar ATPase assembly factor 2 6
MIRT153687 NCOA3 nuclear receptor coactivator 3 2 2
MIRT170929 FOXK1 forkhead box K1 2 2
MIRT219251 RREB1 ras responsive element binding protein 1 2 2
MIRT259552 KLHL15 kelch like family member 15 2 4
MIRT271869 ZNF678 zinc finger protein 678 2 2
MIRT280623 BCL11B B-cell CLL/lymphoma 11B 2 8
MIRT293284 DR1 down-regulator of transcription 1 2 2
MIRT314017 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 8
MIRT374677 AGO4 argonaute 4, RISC catalytic component 2 2
MIRT437385 FMNL2 formin like 2 1 1
MIRT437406 RORA RAR related orphan receptor A 1 1
MIRT437423 KIT KIT proto-oncogene receptor tyrosine kinase 3 1
MIRT437424 AKT2 AKT serine/threonine kinase 2 5 4
MIRT437425 TGFB2 transforming growth factor beta 2 3 1
MIRT437804 SERPINA3 serpin family A member 3 1 1
MIRT437978 COX2 cytochrome c oxidase subunit II 3 1
MIRT438078 TRIM13 tripartite motif containing 13 4 1
MIRT438287 TBX3 T-box 3 1 1
MIRT438288 KLF4 Kruppel like factor 4 1 1
MIRT438537 MTDH metadherin 2 1
MIRT438757 Nr1i3 nuclear receptor subfamily 1, group I, member 3 2 1
MIRT442564 CCDC59 coiled-coil domain containing 59 2 2
MIRT442778 JAG1 jagged 1 2 2
MIRT444302 SREK1IP1 SREK1 interacting protein 1 2 2
MIRT446969 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT448824 FKBP1A FK506 binding protein 1A 2 4
MIRT453617 SNRPE small nuclear ribonucleoprotein polypeptide E 2 4
MIRT459217 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT463490 ZC3H11A zinc finger CCCH-type containing 11A 2 12
MIRT470084 PTGES2 prostaglandin E synthase 2 2 2
MIRT475876 H3F3C H3 histone family member 3C 2 10
MIRT475912 H3F3B H3 histone family member 3B 2 8
MIRT476669 FUT11 fucosyltransferase 11 2 10
MIRT477346 EOGT EGF domain specific O-linked N-acetylglucosamine transferase 2 4
MIRT477596 EIF1 eukaryotic translation initiation factor 1 2 10
MIRT478367 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT479111 CNN2 calponin 2 2 2
MIRT482926 CTPS2 CTP synthase 2 2 2
MIRT485083 SNRK SNF related kinase 2 12
MIRT497120 NBEAL1 neurobeachin like 1 2 2
MIRT498029 UBXN4 UBX domain protein 4 2 8
MIRT500603 UBE2Z ubiquitin conjugating enzyme E2 Z 2 4
MIRT500927 SSFA2 sperm specific antigen 2 2 8
MIRT504324 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT504647 RPL9 ribosomal protein L9 2 6
MIRT506304 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT508007 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT510538 XKR7 XK related 7 2 2
MIRT513051 LYPD6 LY6/PLAUR domain containing 6 2 6
MIRT515223 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT519857 ZFP62 ZFP62 zinc finger protein 2 6
MIRT520508 TRAM2 translocation associated membrane protein 2 2 6
MIRT522047 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT524479 CHRM3 cholinergic receptor muscarinic 3 2 4
MIRT526904 ZNF772 zinc finger protein 772 2 6
MIRT527862 SLC39A14 solute carrier family 39 member 14 2 2
MIRT528601 ZNF326 zinc finger protein 326 2 2
MIRT532950 ZNF24 zinc finger protein 24 2 4
MIRT536275 LMOD2 leiomodin 2 2 2
MIRT537045 GRAMD4 GRAM domain containing 4 2 2
MIRT537124 GOLGA3 golgin A3 2 4
MIRT538884 BTBD1 BTB domain containing 1 2 2
MIRT541457 AURKA aurora kinase A 2 2
MIRT542924 HOXC8 homeobox C8 2 2
MIRT544580 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT545175 RFTN2 raftlin family member 2 2 2
MIRT545248 GTF2E1 general transcription factor IIE subunit 1 2 2
MIRT546473 SLC1A5 solute carrier family 1 member 5 2 2
MIRT547523 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT548071 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548200 FNIP1 folliculin interacting protein 1 2 2
MIRT551216 CIDEC cell death inducing DFFA like effector c 2 2
MIRT553046 USP28 ubiquitin specific peptidase 28 2 2
MIRT553875 SUPT7L SPT7 like, STAGA complex gamma subunit 2 4
MIRT554026 SPCS3 signal peptidase complex subunit 3 2 2
MIRT554153 SLX4 SLX4 structure-specific endonuclease subunit 2 2
MIRT554192 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT554362 SFXN5 sideroflexin 5 2 4
MIRT555349 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT555822 PAX9 paired box 9 2 2
MIRT555866 PAIP1 poly(A) binding protein interacting protein 1 2 2
MIRT555931 NUP43 nucleoporin 43 2 2
MIRT555993 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT556429 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT556582 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT557220 HNRNPDL heterogeneous nuclear ribonucleoprotein D like 2 2
MIRT558490 DBN1 drebrin 1 2 2
MIRT560986 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT562291 GLO1 glyoxalase I 2 2
MIRT564093 TLR3 toll like receptor 3 2 2
MIRT565312 TMEM41A transmembrane protein 41A 2 2
MIRT565424 TEF TEF, PAR bZIP transcription factor 2 2
MIRT566946 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT572369 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT686211 ZNF267 zinc finger protein 267 2 2
MIRT686935 SFT2D3 SFT2 domain containing 3 2 2
MIRT687448 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT710856 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT719484 RBM27 RNA binding motif protein 27 2 2
MIRT719813 TXNDC17 thioredoxin domain containing 17 2 2
MIRT720076 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT723920 ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 2 2
MIRT731305 CUL4A cullin 4A 3 1
MIRT732128 BMP7 bone morphogenetic protein 7 2 1
MIRT732466 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3 0
MIRT732962 TNC tenascin C 1 0
MIRT734856 KDM4A lysine demethylase 4A 3 0
MIRT735625 MEF2A myocyte enhancer factor 2A 2 0
MIRT735795 IL6 interleukin 6 3 0
MIRT736333 DELE1 KIAA0141 2 0
MIRT736610 RUNX2 runt related transcription factor 2 3 0
MIRT736830 NOTCH1 notch 1 3 0
MIRT736888 KCNA2 potassium voltage-gated channel subfamily A member 2 3 0
MIRT737349 EGFR epidermal growth factor receptor 3 0
MIRT755368 GLS glutaminase 2 1
MIRT755431 SPHK2 sphingosine kinase 2 3 1
MIRT756119 USP30 ubiquitin specific peptidase 30 4 1
MIRT756144 XIAP X-linked inhibitor of apoptosis 3 1
MIRT756170 COL5A1 collagen type V alpha 1 chain 3 1
MIRT756171 FSTL1 follistatin like 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-137 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-137 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-137 Emodin NULL 3220 Microarray K562 cells 23744534 2013 down-regualted
miR-137 Emodin NULL 3220 Quantitative real-time PCR K562 cells 23744534 2013 down-regualted
miR-137 Olea europaea leaf extract NULL NULL Quantitative real-time PCR Glioblastoma multiforme tumors cell lines 25232498 2014 up-regualted
miR-137 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-137 Ginsenoside Rh2 NULL 119307 Microarray human glioma cells U251 21372826 2011 up-regulated
miR-137 Interleukin 13 (IL-13) NULL NULL Quantitative real-time PCR esophageal squamous cells 22453679 2012 up-regulated
miR-137 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-137 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-137 Olea europaea leaf extract NULL NULL Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-137 Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-137 Nicotine approved 89594 Microarray Rat adrenal pheochromocytoma PC12 cell 18845019 2009 up-regulated
miR-137 Capecitabine approved 60953 Quantitative real-time PCR rectal cancer 18695884 2008 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-137 Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MDA-MB-231)
hsa-mir-137 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-137 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-137 Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-137 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-137 Topotecan 60699 NSC609699 approved resistant cell line (W1)

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