miRTarBase - #MIRT007346


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pre-miRNA Information
pre-miRNA hsa-mir-137   
Genomic Coordinates chr1: 98046070 - 98046171
Description Homo sapiens miR-137 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-137
Sequence 59| UUAUUGCUUAAGAAUACGCGUAG |81
Evidence Experimental
Experiments Cloned
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B41RDC miR-137 Safety Biomarker (SAF) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol PXN   
Synonyms -
Description paxillin
Transcript NM_001080855   
Other Transcripts NM_002859 , NM_025157   
Expression
Putative miRNA Targets on PXN
3'UTR of PXN
(miRNA target sites are highlighted)		 
>PXN|NM_001080855|3'UTR
   1 GTGCCCTGCCCCTGTCTCTGCCCCCCTTCCCCAGCCAGCATCCCCAACTGCGACTGTGACCTAGAGACTTCACCCGGGGG
  81 TGAAGGGGTAAACCCGACTGAAACTGGAACCCTTGTCCTCCGCTGGTGCGGGATGGACAGAGGGCCGTGAGGGGTCCCCC
 161 TGCTTGTCTTCACCCCTGCCAGAGCCTCTGGGCCCCCTCCTCCCTCCTGTAGCTCTCCCTAGGCTGCCCACTCTCCATCC
 241 TCCCCAGGGGTAGAGGCTGGGGGCTCCACCCCAGCCCATGTACGTCCCCACGAACTGGCCTGGCCAGCACCCCACACTGG
 321 AGCCATCTCTTCCTCATATTTCAGCAGTGCAGCCGGGGGGCAGGGAAGGGCAGGCAGGGTCTGTTGGGGTCTCTTTTTAT
 401 CCTTATTCCTCCCCCGACCTAATTGTCTTTGTTCTGTGATTATTGGGGGACACCCGGCTCCCTCCAGACAATGCCAGCAT
 481 AAATCCATCCATCCAAAGGCAGAGAACCAAAGGGGCCATGGAAGGTTCTCTGTGCTCCTCCTACCCTTCCAGTGCCCTAG
 561 GCCTGGCGACTGCCCCTGCCTTTTAGACCCGCCCTCCCCTTTTATACCTGCTCTTGTTCTACTGAGAAAAGCCTCTCCAG
 641 CAATAATGTTTTCTAGTCACTTCCTCCGTCTCCGGGACGGCGTGCCTGGACACTGTACCGACTTTGATAGATTTCTACAC
 721 TGAGGTTTGAATTCATATCGCCTGAGTTGCTTTTACTTCTCTATACAAAATGATTTTGAAGAGATTTTAAAGACGTTCCC
 801 TTTTGTATTCTCTTCCTCATCCACCGCCACTGGGCCTGTCACTGATGGTGGCTCTGGTGTGAAGTTTGCTTTGTACTGAG
 881 GGTTGGGGTGGGGAAGCAATTTGTATTTTATTGTTTCTTAGCACAAGCAGGTGAACTGGGAGCAGCTCTGTGACTCCCCC
 961 TCTTTCACTTCATAGCTCACCAGGACTGTTTTATAAACTGCTGTATTTGGAAACCCCTTCTTTACTTCCCAGGCCAGCAA
1041 GCTCTTCACTGAAACTGGTTGAAGGGTGTTGCACCCTTTTGGGCCTAGAATTCTGAACTTTATCTGTTCTGTTTCTGTGG
1121 GAGGAGAAGGGGAAGTATGTTTTGGGGGGCTGCTTCCTGTCTGAGTAAGCCCTCAGGAGCCTCTGCTCCCCTGTGAACCC
1201 ACTGAACCTTCTGAGCCCCCACTGCTTCTATGGGGCTCTCTCTTCTGCCTTCTCAGGAAAGCTGGTGTCTGATTTTGGCC
1281 ATCAGGACTCTGACGTCTCTTTGGTCTTGTTGATTTCCTCTGGGCATATCCCTTCCCCAGATCTGCTCCTCCCCTTTCAC
1361 AGGTGGGATCGGCACTCAGGGGGTCTGGAAAGAAGGTCATAAGGGAGCATGATAGGATTTGGGGCAGAGGGACAGGCTCC
1441 TCTGGGGAAACCCCCCAGAGCTCTTTACCAAGGATGAAAGAGGAGCCAGGCCTTGGGCTCCTGATGAGGAGAAAGGGGCC
1521 CCACCGGGGTCTAATGGTGACAGTCCAAACCACTCCACTGGCCTCCTGGCAGAAGCCGAGTGTGCTGGGGTCTCCGAAGA
1601 GGGTCCCTCCTTTTTGGGGGAAGGTCAGCCCAGCCCCTCCAAAGGTCTGATGTCTCCACTTTCACCCGCAGGCCTTACCG
1681 CTCTGTTTATAGTGACCCACCCTAGATCTTCCCCAAGAGGGACTGGGGTTTCTGGGGTCCATTCTCTGAGTCAGTGGTTA
1761 TTTGAAAATTTGATTTTGATTTTATTTTTTCTCTGTAAACTTCCAAGCTGGCTTTTCCCATTTCAATTCCTGTGATTTAT
1841 GCCAATAAAGTTTGCCCATGATTTTCACCTGTGCT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaugcgcauaAGAAUUCGUUAUu 5'
                    |||  ||||||| 
Target 5' gagaaaagccTCTCCAGCAATAa 3'
 624 - 646 149.00 -8.10
2 
miRNA  3' gaugcgcauaagaaUUCGUUAuu 5'
                        |||||||  
Target 5' gggttggggtggggAAGCAATtt 3'
 880 - 902 125.00 -9.00
3 
miRNA  3' gauGCGCAUAAGAAUUCGUUAUu 5'
             | | |||  || ||||:|: 
Target 5' ttcCTCATAT--TTCAGCAGTGc 3'
 330 - 350 124.00 -5.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30477417 3 COSMIC
COSN31488010 6 COSMIC
COSN5713193 19 COSMIC
COSN30462678 20 COSMIC
COSN30174304 29 COSMIC
COSN30133781 51 COSMIC
COSN31500016 56 COSMIC
COSN26600959 83 COSMIC
COSN31485917 122 COSMIC
COSN28658699 147 COSMIC
COSN26564926 173 COSMIC
COSN30188869 183 COSMIC
COSN1559940 189 COSMIC
COSN30497608 216 COSMIC
COSN30157422 253 COSMIC
COSN31499150 304 COSMIC
COSN26991167 312 COSMIC
COSN510288 318 COSMIC
COSN31492354 334 COSMIC
COSN20061169 346 COSMIC
COSN13243100 354 COSMIC
COSN30463405 356 COSMIC
COSN30447074 364 COSMIC
COSN31958755 418 COSMIC
COSN31596787 652 COSMIC
COSN31590178 686 COSMIC
COSN26538074 695 COSMIC
COSN28693242 825 COSMIC
COSN31606454 956 COSMIC
COSN8585463 1292 COSMIC
COSN26579882 1401 COSMIC
COSN31482979 1500 COSMIC
COSN31588018 1665 COSMIC
COSN17075712 1808 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1437346868 5 dbSNP
rs889369953 6 dbSNP
rs1051157851 7 dbSNP
rs140367844 8 dbSNP
rs750611347 9 dbSNP
rs1290948509 11 dbSNP
rs1243556182 13 dbSNP
rs769355352 14 dbSNP
rs772832049 14 dbSNP
rs765535652 16 dbSNP
rs762172536 21 dbSNP
rs769212427 22 dbSNP
rs761152303 24 dbSNP
rs1450582949 25 dbSNP
rs761311631 25 dbSNP
rs773894457 26 dbSNP
rs748911095 28 dbSNP
rs1320289807 29 dbSNP
rs777423522 39 dbSNP
rs769477361 47 dbSNP
rs920726681 51 dbSNP
rs1293695629 52 dbSNP
rs1309689827 65 dbSNP
rs972238764 75 dbSNP
rs1263067474 76 dbSNP
rs564545490 79 dbSNP
rs551071061 80 dbSNP
rs1474979150 81 dbSNP
rs1016264697 90 dbSNP
rs1184474762 95 dbSNP
rs555376512 96 dbSNP
rs889193993 104 dbSNP
rs562117346 110 dbSNP
rs982094583 111 dbSNP
rs765045352 114 dbSNP
rs770644352 121 dbSNP
rs541907834 122 dbSNP
rs1176667736 129 dbSNP
rs573194301 134 dbSNP
rs1052656746 139 dbSNP
rs3742039 147 dbSNP
rs924962171 155 dbSNP
rs1282981803 158 dbSNP
rs1333628365 162 dbSNP
rs576940787 163 dbSNP
rs1279939663 166 dbSNP
rs545967803 166 dbSNP
rs1315829965 168 dbSNP
rs957987473 169 dbSNP
rs1229696132 177 dbSNP
rs577042317 196 dbSNP
rs1488386100 198 dbSNP
rs1198212179 199 dbSNP
rs1278863962 200 dbSNP
rs1266561471 204 dbSNP
rs1439809906 209 dbSNP
rs73412896 228 dbSNP
rs1244609226 229 dbSNP
rs1423149171 234 dbSNP
rs781119381 236 dbSNP
rs755014207 238 dbSNP
rs947807610 242 dbSNP
rs1469768998 246 dbSNP
rs999341521 247 dbSNP
rs537952263 248 dbSNP
rs780020102 255 dbSNP
rs1268154750 260 dbSNP
rs758446793 263 dbSNP
rs1448554446 266 dbSNP
rs756951756 269 dbSNP
rs750616554 271 dbSNP
rs1204317153 275 dbSNP
rs991954810 278 dbSNP
rs535183529 279 dbSNP
rs1454007817 280 dbSNP
rs1284770717 281 dbSNP
rs765563957 283 dbSNP
rs762012866 284 dbSNP
rs1373196678 291 dbSNP
rs575081685 291 dbSNP
rs201063727 292 dbSNP
rs367774069 294 dbSNP
rs1221367266 295 dbSNP
rs1048067757 298 dbSNP
rs775923370 299 dbSNP
rs1490783026 301 dbSNP
rs770358126 310 dbSNP
rs762456329 311 dbSNP
rs772591086 313 dbSNP
rs769542203 316 dbSNP
rs200434219 318 dbSNP
rs1476319336 319 dbSNP
rs781172802 320 dbSNP
rs1192252880 322 dbSNP
rs1445043472 325 dbSNP
rs1264641432 328 dbSNP
rs1203859116 329 dbSNP
rs768522912 330 dbSNP
rs776054329 330 dbSNP
rs1322220697 336 dbSNP
rs143567159 339 dbSNP
rs1215801584 344 dbSNP
rs1363875355 345 dbSNP
rs779976594 350 dbSNP
rs372103577 354 dbSNP
rs746021059 355 dbSNP
rs1354290276 356 dbSNP
rs763443985 357 dbSNP
rs754024393 358 dbSNP
rs1470387946 359 dbSNP
rs139268715 361 dbSNP
rs1466719283 361 dbSNP
rs1459142926 362 dbSNP
rs948163870 369 dbSNP
rs746873094 372 dbSNP
rs1174449694 373 dbSNP
rs764460323 378 dbSNP
rs1420198109 379 dbSNP
rs756409382 380 dbSNP
rs1000212568 384 dbSNP
rs753145814 388 dbSNP
rs768133872 389 dbSNP
rs760695734 392 dbSNP
rs1460639962 397 dbSNP
rs989507354 400 dbSNP
rs772827116 403 dbSNP
rs764621183 404 dbSNP
rs1274355415 409 dbSNP
rs1214454232 412 dbSNP
rs1383644788 413 dbSNP
rs761589305 415 dbSNP
rs776365835 416 dbSNP
rs1453822705 417 dbSNP
rs772736242 422 dbSNP
rs768576484 423 dbSNP
rs746869375 425 dbSNP
rs1444487199 430 dbSNP
rs1355148133 435 dbSNP
rs570976594 436 dbSNP
rs1408081296 439 dbSNP
rs367869069 443 dbSNP
rs772098204 444 dbSNP
rs1443752762 449 dbSNP
rs916338025 450 dbSNP
rs1451317559 452 dbSNP
rs1334060293 454 dbSNP
rs745765622 455 dbSNP
rs779085013 456 dbSNP
rs757273638 459 dbSNP
rs1269220560 463 dbSNP
rs1231752191 464 dbSNP
rs10128770 467 dbSNP
rs972527574 468 dbSNP
rs1322673841 470 dbSNP
rs1452940998 485 dbSNP
rs1201670475 493 dbSNP
rs962963686 498 dbSNP
rs557223286 501 dbSNP
rs1444197535 504 dbSNP
rs953834611 504 dbSNP
rs1188581940 506 dbSNP
rs1027041753 514 dbSNP
rs180723672 515 dbSNP
rs1190149195 517 dbSNP
rs1485960741 518 dbSNP
rs899401819 519 dbSNP
rs1424998985 530 dbSNP
rs1241027866 532 dbSNP
rs1212949317 534 dbSNP
rs141268319 537 dbSNP
rs1280937449 540 dbSNP
rs188310937 541 dbSNP
rs1414527142 543 dbSNP
rs906658831 543 dbSNP
rs1324281766 544 dbSNP
rs531031723 545 dbSNP
rs976206785 549 dbSNP
rs1344606732 550 dbSNP
rs1221682195 551 dbSNP
rs35029538 562 dbSNP
rs948104500 567 dbSNP
rs916695181 568 dbSNP
rs1201044223 573 dbSNP
rs1283860769 579 dbSNP
rs1361454868 585 dbSNP
rs562083798 587 dbSNP
rs1287257549 588 dbSNP
rs1054184888 590 dbSNP
rs936722747 591 dbSNP
rs923859470 595 dbSNP
rs977939629 596 dbSNP
rs548551087 599 dbSNP
rs1480309583 607 dbSNP
rs1376649691 612 dbSNP
rs965273207 616 dbSNP
rs562741863 619 dbSNP
rs528496571 622 dbSNP
rs1312778039 636 dbSNP
rs763556842 647 dbSNP
rs1433362177 648 dbSNP
rs1372816893 653 dbSNP
rs985330168 656 dbSNP
rs1364797247 657 dbSNP
rs369147417 663 dbSNP
rs1026762705 664 dbSNP
rs974138035 667 dbSNP
rs767466857 668 dbSNP
rs759367894 672 dbSNP
rs546102457 673 dbSNP
rs142848708 674 dbSNP
rs1015268939 678 dbSNP
rs1012904725 679 dbSNP
rs1210115844 681 dbSNP
rs1490291592 682 dbSNP
rs1484617566 689 dbSNP
rs1208362820 690 dbSNP
rs1276516792 699 dbSNP
rs1204953713 700 dbSNP
rs1307194089 704 dbSNP
rs894853571 705 dbSNP
rs1378023420 708 dbSNP
rs1440985543 713 dbSNP
rs1056037829 717 dbSNP
rs563908171 722 dbSNP
rs1384151011 730 dbSNP
rs1005100885 735 dbSNP
rs1356214183 739 dbSNP
rs896881412 740 dbSNP
rs762491722 744 dbSNP
rs906795249 745 dbSNP
rs1037292018 746 dbSNP
rs1374835403 772 dbSNP
rs1242328826 773 dbSNP
rs1310267616 776 dbSNP
rs941166519 789 dbSNP
rs376623472 794 dbSNP
rs1012447562 795 dbSNP
rs774128735 798 dbSNP
rs1053916603 800 dbSNP
rs536915315 802 dbSNP
rs771201988 804 dbSNP
rs1458718252 812 dbSNP
rs764930237 813 dbSNP
rs143564345 821 dbSNP
rs902488594 824 dbSNP
rs1042383253 825 dbSNP
rs186156220 826 dbSNP
rs1299165118 830 dbSNP
rs1461784064 831 dbSNP
rs1421735575 833 dbSNP
rs912502351 840 dbSNP
rs921955017 843 dbSNP
rs1353609513 845 dbSNP
rs148534498 847 dbSNP
rs1461284147 851 dbSNP
rs976049624 859 dbSNP
rs966134501 870 dbSNP
rs536673690 871 dbSNP
rs1449128145 876 dbSNP
rs932534557 880 dbSNP
rs1031051641 885 dbSNP
rs978672432 907 dbSNP
rs968277386 927 dbSNP
rs1417968859 931 dbSNP
rs1322716732 935 dbSNP
rs919666804 949 dbSNP
rs1022883502 953 dbSNP
rs1256754513 957 dbSNP
rs1320563700 959 dbSNP
rs1186521561 960 dbSNP
rs1199793945 961 dbSNP
rs1012523331 964 dbSNP
rs1481984681 965 dbSNP
rs1183291052 966 dbSNP
rs895389704 969 dbSNP
rs1169463210 971 dbSNP
rs1191186465 988 dbSNP
rs1425714703 991 dbSNP
rs973808092 998 dbSNP
rs1177623039 1000 dbSNP
rs1034661033 1025 dbSNP
rs961121583 1030 dbSNP
rs1003139783 1033 dbSNP
rs1249366769 1038 dbSNP
rs1015239282 1046 dbSNP
rs896912668 1055 dbSNP
rs1036751483 1059 dbSNP
rs1276751526 1072 dbSNP
rs981120454 1072 dbSNP
rs970957183 1084 dbSNP
rs1050010133 1093 dbSNP
rs1335646030 1101 dbSNP
rs1272626368 1104 dbSNP
rs1256257082 1106 dbSNP
rs1231521927 1111 dbSNP
rs1265151485 1115 dbSNP
rs932566710 1121 dbSNP
rs1025260862 1124 dbSNP
rs1422898578 1127 dbSNP
rs1308309864 1134 dbSNP
rs541823552 1139 dbSNP
rs1359793762 1147 dbSNP
rs536493747 1148 dbSNP
rs1419370399 1150 dbSNP
rs1371670329 1164 dbSNP
rs1012829857 1172 dbSNP
rs1362907111 1175 dbSNP
rs1442655809 1180 dbSNP
rs572893225 1181 dbSNP
rs1163658856 1189 dbSNP
rs1366059616 1202 dbSNP
rs1032932654 1204 dbSNP
rs773349872 1208 dbSNP
rs902624993 1210 dbSNP
rs36019272 1211 dbSNP
rs113068849 1216 dbSNP
rs978238976 1220 dbSNP
rs1159787046 1222 dbSNP
rs944069885 1224 dbSNP
rs1418385309 1229 dbSNP
rs891028197 1230 dbSNP
rs1221413932 1234 dbSNP
rs1244935543 1237 dbSNP
rs1489453053 1239 dbSNP
rs915440392 1244 dbSNP
rs1426039836 1255 dbSNP
rs769725305 1256 dbSNP
rs1157091201 1288 dbSNP
rs1382330378 1292 dbSNP
rs932564025 1295 dbSNP
rs144770838 1299 dbSNP
rs1348476302 1317 dbSNP
rs974323920 1320 dbSNP
rs748715806 1326 dbSNP
rs1294619335 1329 dbSNP
rs1252595721 1341 dbSNP
rs908314131 1343 dbSNP
rs1211953474 1344 dbSNP
rs961063736 1351 dbSNP
rs1353918942 1366 dbSNP
rs981097551 1367 dbSNP
rs1015675750 1370 dbSNP
rs781602972 1371 dbSNP
rs570806623 1379 dbSNP
rs1176812448 1380 dbSNP
rs915568044 1380 dbSNP
rs1238987081 1381 dbSNP
rs567503768 1382 dbSNP
rs991055941 1383 dbSNP
rs1162856888 1384 dbSNP
rs1412154718 1399 dbSNP
rs1315583831 1410 dbSNP
rs1407377447 1419 dbSNP
rs373029860 1421 dbSNP
rs959904266 1428 dbSNP
rs1032487618 1430 dbSNP
rs1400157590 1433 dbSNP
rs1443970217 1437 dbSNP
rs111453834 1440 dbSNP
rs1303955161 1444 dbSNP
rs867603035 1451 dbSNP
rs966754053 1452 dbSNP
rs1021027724 1455 dbSNP
rs996641823 1457 dbSNP
rs1257380096 1460 dbSNP
rs1315935018 1462 dbSNP
rs1008180516 1477 dbSNP
rs901096291 1491 dbSNP
rs1260120571 1493 dbSNP
rs891087721 1495 dbSNP
rs1050196783 1496 dbSNP
rs1288888340 1506 dbSNP
rs1235880709 1512 dbSNP
rs934561674 1517 dbSNP
rs1452968156 1526 dbSNP
rs1361987069 1532 dbSNP
rs1464559950 1541 dbSNP
rs996744184 1541 dbSNP
rs1173454747 1553 dbSNP
rs898423446 1554 dbSNP
rs1038190409 1556 dbSNP
rs1331791603 1560 dbSNP
rs1341847384 1563 dbSNP
rs1448510840 1566 dbSNP
rs1042769090 1570 dbSNP
rs1338110727 1577 dbSNP
rs939871643 1580 dbSNP
rs946835694 1595 dbSNP
rs1394747818 1596 dbSNP
rs915288591 1599 dbSNP
rs990951122 1600 dbSNP
rs1199902961 1604 dbSNP
rs908290361 1605 dbSNP
rs959499620 1619 dbSNP
rs149828972 1629 dbSNP
rs1262533666 1632 dbSNP
rs536885801 1638 dbSNP
rs12423375 1641 dbSNP
rs1015290976 1648 dbSNP
rs1283065022 1652 dbSNP
rs1424878530 1658 dbSNP
rs991581612 1663 dbSNP
rs1005604903 1667 dbSNP
rs548417005 1668 dbSNP
rs1403693972 1671 dbSNP
rs1301647025 1679 dbSNP
rs1414720039 1680 dbSNP
rs1231647574 1685 dbSNP
rs1327765565 1692 dbSNP
rs1295748709 1704 dbSNP
rs528432206 1705 dbSNP
rs181601418 1708 dbSNP
rs979561228 1713 dbSNP
rs1330400781 1715 dbSNP
rs1230952196 1716 dbSNP
rs753390851 1720 dbSNP
rs1382756609 1721 dbSNP
rs966888203 1722 dbSNP
rs1314609060 1725 dbSNP
rs1347214896 1736 dbSNP
rs1021081530 1739 dbSNP
rs1285502972 1744 dbSNP
rs777363403 1752 dbSNP
rs1219192387 1754 dbSNP
rs147333340 1754 dbSNP
rs1263071026 1755 dbSNP
rs1451586700 1764 dbSNP
rs1197333183 1768 dbSNP
rs901043951 1769 dbSNP
rs112475932 1770 dbSNP
rs1028299199 1772 dbSNP
rs1476551431 1782 dbSNP
rs1802681 1791 dbSNP
rs142692534 1807 dbSNP
rs1298633147 1817 dbSNP
rs1389713773 1826 dbSNP
rs1385079549 1828 dbSNP
rs759457705 1841 dbSNP
rs751371378 1845 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HCT116 , SW620 , HT-29
Location of target site 3'UTR
Tools used in this research miRanda , TargetScan
Original Description (Extracted from the article) ... The binding sites of miR-137 in the PXN 3芒鈧虏UTR. ...

- Chen DL; Wang DS; Wu WJ; Zeng ZL; Luo HY; et al., 2013, Carcinogenesis.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaugcgcauaAGAAUUCGUUAUu 5'
                    |||  ||||||| 
Target 5' gagaaaagccUCUCCAGCAAUAa 3'
 		1 - 23
Article - Chen DL; Wang DS; Wu WJ; Zeng ZL; Luo HY; et al.
- Carcinogenesis, 2013
The deregulation of paxillin (PXN) has been involved in the progression and metastasis of different malignancies including colorectal cancer (CRC). miR-137 is frequently suppressed in CRC. PXN is predicted to be a direct target of miR-137 in CRC cells. On this basis, we hypothesized that overexpression of PXN induced by suppression of miR-137 may promote tumor progression and metastasis and predicts poor prognosis. We detected the expression of PXN and miR-137 in clinical tumor tissues by immunohistochemical analysis and real-time PCR, positive PXN staining was observed in 198 of the 247 (80.1%) cases, whereas no or weak PXN staining was observed in the adjacent non-cancerous area. Higher level of PXN messenger RNA (mRNA) and lower level of miR-137 was observed in cancer tissues than adjacent non-cancerous tissues. High expression of PXN and low expression of miR-137 was associated with aggressive tumor phenotype and adverse prognosis. Moreover, the expression of PXN was negatively correlated with miR-137 expression. A dual-luciferase reporter gene assay validated that PXN was a direct target of miR-137. The use of miR-137 mimics or inhibitor could decrease or increase PXN mRNA and protein levels in CRC cell lines. Knockdown of PXN or ectopic expression of miR-137 could markedly inhibit cell proliferation, migration and invasion in vitro and repress tumor growth and metastasis in vivo. Taken together, these results demonstrated that overexpression of PXN induced by suppression of miR-137 promotes tumor progression and metastasis and could serve as an independent prognostic indicator in CRC patients.
LinkOut: [PMID: 23275153]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21687 Ependynoma primary tumors -0.262 1.8e-2 -0.057 3.3e-1 64 Click to see details
GSE28260 Renal cortex and medulla 0.525 3.3e-2 0.467 5.4e-2 13 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.344 4.6e-2 -0.335 5.1e-2 25 Click to see details
GSE28544 Breast cancer -0.298 7.9e-2 -0.368 3.8e-2 24 Click to see details
GSE27834 Pluripotent stem cells -0.339 9.9e-2 -0.479 3.0e-2 16 Click to see details
GSE19350 CNS germ cell tumors 0.358 1.3e-1 0.458 6.7e-2 12 Click to see details
GSE17498 Multiple myeloma -0.168 1.5e-1 -0.248 6.1e-2 40 Click to see details
GSE14794 Lymphoblastoid cells -0.082 2.2e-1 -0.055 3.0e-1 90 Click to see details
GSE38226 Liver fibrosis 0.144 2.7e-1 -0.040 4.3e-1 21 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.086 3.6e-1 0.179 2.3e-1 20 Click to see details
GSE32688 Pancreatic cancer 0.065 3.6e-1 0.087 3.2e-1 32 Click to see details
GSE42095 Differentiated embryonic stem cells -0.03 4.5e-1 0.240 1.4e-1 23 Click to see details
GSE26953 Aortic valvular endothelial cells -0.011 4.8e-1 -0.204 1.7e-1 24 Click to see details
GSE26953 Aortic valvular endothelial cells -0.011 4.8e-1 -0.204 1.7e-1 24 Click to see details
GSE26953 Aortic valvular endothelial cells -0.011 4.8e-1 -0.204 1.7e-1 24 Click to see details
GSE26953 Aortic valvular endothelial cells -0.011 4.8e-1 -0.204 1.7e-1 24 Click to see details
GSE26953 Aortic valvular endothelial cells -0.011 4.8e-1 -0.204 1.7e-1 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
CHOL 0.888 0.06 0.200 0.4 4 Click to see details
STAD -0.298 0.16 -0.159 0.3 13 Click to see details
UCEC -0.504 0.25 -0.400 0.3 4 Click to see details
PRAD 0.139 0.26 0.153 0.24 24 Click to see details
BRCA -0.196 0.35 -0.543 0.13 6 Click to see details
HNSC 0.07 0.36 -0.009 0.48 29 Click to see details
LUSC -0.146 0.38 -0.179 0.35 7 Click to see details
PAAD 0.244 0.38 0.400 0.3 4 Click to see details
KIRP 0.122 0.39 0.048 0.46 8 Click to see details
KICH -0.141 0.43 0.600 0.2 4 Click to see details
PCPG 0.124 0.46 -0.500 0.33 3 Click to see details
THCA 0.018 0.46 0.010 0.48 27 Click to see details
BLCA -0.039 0.48 -0.200 0.4 4 Click to see details
ESCA -0.039 0.48 -0.200 0.4 4 Click to see details
LIHC 0.026 0.49 -0.500 0.33 3 Click to see details
LIHC 0.026 0.49 -0.500 0.33 3 Click to see details
LIHC 0.026 0.49 -0.500 0.33 3 Click to see details
LIHC 0.026 0.49 -0.500 0.33 3 Click to see details
140 hsa-miR-137 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT002489 E2F6 E2F transcription factor 6 4 1
MIRT002490 CDK6 cyclin dependent kinase 6 4 7
MIRT004004 NCOA2 nuclear receptor coactivator 2 4 1
MIRT004579 KDM1A lysine demethylase 1A 5 3
MIRT005485 CDC42 cell division cycle 42 4 4
MIRT005605 CTBP1 C-terminal binding protein 1 4 1
MIRT005883 MITF melanogenesis associated transcription factor 3 1
MIRT006329 PTGS2 prostaglandin-endoperoxide synthase 2 2 1
MIRT006957 ESRRA estrogen related receptor alpha 1 1
MIRT007068 ZNF804A zinc finger protein 804A 1 1
MIRT007092 YBX1 Y-box binding protein 1 3 3
MIRT007252 CSE1L chromosome segregation 1 like 2 1
MIRT007346 PXN paxillin 3 1
MIRT053056 GLIPR1 GLI pathogenesis related 1 3 1
MIRT053225 MET MET proto-oncogene, receptor tyrosine kinase 3 1
MIRT054547 FUNDC1 FUN14 domain containing 1 3 1
MIRT054568 BNIP3L BCL2 interacting protein 3 like 3 1
MIRT090615 PLS1 plastin 1 2 2
MIRT093393 TMA16 translation machinery associated 16 homolog 2 2
MIRT109230 VMA21 VMA21, vacuolar ATPase assembly factor 2 6
MIRT153687 NCOA3 nuclear receptor coactivator 3 2 2
MIRT170929 FOXK1 forkhead box K1 2 2
MIRT219251 RREB1 ras responsive element binding protein 1 2 2
MIRT259552 KLHL15 kelch like family member 15 2 4
MIRT271869 ZNF678 zinc finger protein 678 2 2
MIRT280623 BCL11B B-cell CLL/lymphoma 11B 2 8
MIRT293284 DR1 down-regulator of transcription 1 2 2
MIRT314017 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 8
MIRT374677 AGO4 argonaute 4, RISC catalytic component 2 2
MIRT437385 FMNL2 formin like 2 1 1
MIRT437406 RORA RAR related orphan receptor A 1 1
MIRT437423 KIT KIT proto-oncogene receptor tyrosine kinase 3 1
MIRT437424 AKT2 AKT serine/threonine kinase 2 5 4
MIRT437425 TGFB2 transforming growth factor beta 2 3 1
MIRT437804 SERPINA3 serpin family A member 3 1 1
MIRT437978 COX2 cytochrome c oxidase subunit II 3 1
MIRT438078 TRIM13 tripartite motif containing 13 4 1
MIRT438287 TBX3 T-box 3 1 1
MIRT438288 KLF4 Kruppel like factor 4 1 1
MIRT438537 MTDH metadherin 2 1
MIRT438757 Nr1i3 nuclear receptor subfamily 1, group I, member 3 2 1
MIRT442564 CCDC59 coiled-coil domain containing 59 2 2
MIRT442778 JAG1 jagged 1 2 2
MIRT444302 SREK1IP1 SREK1 interacting protein 1 2 2
MIRT446969 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT448824 FKBP1A FK506 binding protein 1A 2 4
MIRT453617 SNRPE small nuclear ribonucleoprotein polypeptide E 2 4
MIRT459217 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT463490 ZC3H11A zinc finger CCCH-type containing 11A 2 12
MIRT470084 PTGES2 prostaglandin E synthase 2 2 2
MIRT475876 H3F3C H3 histone family member 3C 2 10
MIRT475912 H3F3B H3 histone family member 3B 2 8
MIRT476669 FUT11 fucosyltransferase 11 2 10
MIRT477346 EOGT EGF domain specific O-linked N-acetylglucosamine transferase 2 4
MIRT477596 EIF1 eukaryotic translation initiation factor 1 2 10
MIRT478367 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT479111 CNN2 calponin 2 2 2
MIRT482926 CTPS2 CTP synthase 2 2 2
MIRT485083 SNRK SNF related kinase 2 12
MIRT497120 NBEAL1 neurobeachin like 1 2 2
MIRT498029 UBXN4 UBX domain protein 4 2 8
MIRT500603 UBE2Z ubiquitin conjugating enzyme E2 Z 2 4
MIRT500927 SSFA2 sperm specific antigen 2 2 8
MIRT504324 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT504647 RPL9 ribosomal protein L9 2 6
MIRT506304 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT508007 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT510538 XKR7 XK related 7 2 2
MIRT513051 LYPD6 LY6/PLAUR domain containing 6 2 6
MIRT515223 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT519857 ZFP62 ZFP62 zinc finger protein 2 6
MIRT520508 TRAM2 translocation associated membrane protein 2 2 6
MIRT522047 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT524479 CHRM3 cholinergic receptor muscarinic 3 2 4
MIRT526904 ZNF772 zinc finger protein 772 2 6
MIRT527862 SLC39A14 solute carrier family 39 member 14 2 2
MIRT528601 ZNF326 zinc finger protein 326 2 2
MIRT532950 ZNF24 zinc finger protein 24 2 4
MIRT536275 LMOD2 leiomodin 2 2 2
MIRT537045 GRAMD4 GRAM domain containing 4 2 2
MIRT537124 GOLGA3 golgin A3 2 4
MIRT538884 BTBD1 BTB domain containing 1 2 2
MIRT541457 AURKA aurora kinase A 2 2
MIRT542924 HOXC8 homeobox C8 2 2
MIRT544580 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT545175 RFTN2 raftlin family member 2 2 2
MIRT545248 GTF2E1 general transcription factor IIE subunit 1 2 2
MIRT546473 SLC1A5 solute carrier family 1 member 5 2 2
MIRT547523 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT548071 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548200 FNIP1 folliculin interacting protein 1 2 2
MIRT551216 CIDEC cell death inducing DFFA like effector c 2 2
MIRT553046 USP28 ubiquitin specific peptidase 28 2 2
MIRT553875 SUPT7L SPT7 like, STAGA complex gamma subunit 2 4
MIRT554026 SPCS3 signal peptidase complex subunit 3 2 2
MIRT554153 SLX4 SLX4 structure-specific endonuclease subunit 2 2
MIRT554192 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT554362 SFXN5 sideroflexin 5 2 4
MIRT555349 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT555822 PAX9 paired box 9 2 2
MIRT555866 PAIP1 poly(A) binding protein interacting protein 1 2 2
MIRT555931 NUP43 nucleoporin 43 2 2
MIRT555993 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT556429 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT556582 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT557220 HNRNPDL heterogeneous nuclear ribonucleoprotein D like 2 2
MIRT558490 DBN1 drebrin 1 2 2
MIRT560986 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT562291 GLO1 glyoxalase I 2 2
MIRT564093 TLR3 toll like receptor 3 2 2
MIRT565312 TMEM41A transmembrane protein 41A 2 2
MIRT565424 TEF TEF, PAR bZIP transcription factor 2 2
MIRT566946 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT572369 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT686211 ZNF267 zinc finger protein 267 2 2
MIRT686935 SFT2D3 SFT2 domain containing 3 2 2
MIRT687448 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT710856 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT719484 RBM27 RNA binding motif protein 27 2 2
MIRT719813 TXNDC17 thioredoxin domain containing 17 2 2
MIRT720076 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT723920 ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 2 2
MIRT731305 CUL4A cullin 4A 3 1
MIRT732128 BMP7 bone morphogenetic protein 7 2 1
MIRT732466 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3 0
MIRT732962 TNC tenascin C 1 0
MIRT734856 KDM4A lysine demethylase 4A 3 0
MIRT735625 MEF2A myocyte enhancer factor 2A 2 0
MIRT735795 IL6 interleukin 6 3 0
MIRT736333 DELE1 KIAA0141 2 0
MIRT736610 RUNX2 runt related transcription factor 2 3 0
MIRT736830 NOTCH1 notch 1 3 0
MIRT736888 KCNA2 potassium voltage-gated channel subfamily A member 2 3 0
MIRT737349 EGFR epidermal growth factor receptor 3 0
MIRT755368 GLS glutaminase 2 1
MIRT755431 SPHK2 sphingosine kinase 2 3 1
MIRT756119 USP30 ubiquitin specific peptidase 30 4 1
MIRT756144 XIAP X-linked inhibitor of apoptosis 3 1
MIRT756170 COL5A1 collagen type V alpha 1 chain 3 1
MIRT756171 FSTL1 follistatin like 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-137 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-137 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-137 Emodin NULL 3220 Microarray K562 cells 23744534 2013 down-regualted
miR-137 Emodin NULL 3220 Quantitative real-time PCR K562 cells 23744534 2013 down-regualted
miR-137 Olea europaea leaf extract NULL NULL Quantitative real-time PCR Glioblastoma multiforme tumors cell lines 25232498 2014 up-regualted
miR-137 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-137 Ginsenoside Rh2 NULL 119307 Microarray human glioma cells U251 21372826 2011 up-regulated
miR-137 Interleukin 13 (IL-13) NULL NULL Quantitative real-time PCR esophageal squamous cells 22453679 2012 up-regulated
miR-137 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-137 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-137 Olea europaea leaf extract NULL NULL Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-137 Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-137 Nicotine approved 89594 Microarray Rat adrenal pheochromocytoma PC12 cell 18845019 2009 up-regulated
miR-137 Capecitabine approved 60953 Quantitative real-time PCR rectal cancer 18695884 2008 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-137 Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MDA-MB-231)
hsa-mir-137 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-137 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-137 Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-137 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-137 Topotecan 60699 NSC609699 approved resistant cell line (W1)

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