pre-miRNA Information | |
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pre-miRNA | mmu-mir-122 |
Genomic Coordinates | chr18: 65248861 - 65248926 |
Synonyms | Mirn122a, mmu-mir-122, Mir122a |
Description | Mus musculus miR-122 stem-loop |
Comment | The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies . |
RNA Secondary Structure | ![]() |
Mature miRNA Information | |
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Mature miRNA | mmu-miR-122-5p |
Sequence | 6| UGGAGUGUGACAAUGGUGUUUG |27 |
Evidence | Experimental |
Experiments | Cloned |
Putative Targets |
Biomarker Information |
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Gene Information | |
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Gene Symbol | Mir451 |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Article |
- Castoldi M; Vujic Spasic M; Altamura S; et al. - The Journal of clinical investigation, 2011
Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release. Here we show that the liver-specific microRNA miR-122 is important for regulating Hamp mRNA expression and tissue iron levels. Efficient and specific depletion of miR-122 by injection of a locked-nucleic-acid-modified (LNA-modified) anti-miR into WT mice caused systemic iron deficiency, characterized by reduced plasma and liver iron levels, mildly impaired hematopoiesis, and increased extramedullary erythropoiesis in the spleen. Moreover, miR-122 inhibition increased the amount of mRNA transcribed by genes that control systemic iron levels, such as hemochromatosis (Hfe), hemojuvelin (Hjv), bone morphogenetic protein receptor type 1A (Bmpr1a), and Hamp. Importantly, miR-122 directly targeted the 3' untranslated region of 2 mRNAs that encode activators of hepcidin expression, Hfe and Hjv. These data help to explain the increased Hamp mRNA levels and subsequent iron deficiency in mice with reduced miR-122 levels and establish a direct mechanistic link between miR-122 and the regulation of systemic iron metabolism.
LinkOut: [PMID: 21364282]
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86 mmu-miR-122-5p Target Genes:
Functional analysis:
ID![]() |
Target | Description | Validation methods |
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Strong evidence | Less strong evidence | |||||||||||
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MIRT003075 | Tmem50b | transmembrane protein 50B | ![]() |
1 | 1 | |||||||
MIRT003076 | Lass6 | ceramide synthase 6 | ![]() |
1 | 1 | |||||||
MIRT003077 | Gpx7 | glutathione peroxidase 7 | ![]() |
1 | 1 | |||||||
MIRT003113 | Tgfbr1 | transforming growth factor, beta receptor I | ![]() |
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3 | 1 | |||||
MIRT003114 | Sbk1 | SH3-binding kinase 1 | ![]() |
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3 | 1 | |||||
MIRT003117 | Hist1h1c | histone cluster 1, H1c | ![]() |
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3 | 1 | |||||
MIRT003118 | Ddc | dopa decarboxylase | ![]() |
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2 | 1 | ||||||
MIRT003120 | Rell1 | RELT-like 1 | ![]() |
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3 | 1 | |||||
MIRT003121 | Bach1 | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | ![]() |
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2 | 1 | ||||||
MIRT003122 | Apob | apolipoprotein B | ![]() |
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2 | 1 | ||||||
MIRT003123 | P4ha1 | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide | ![]() |
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2 | 1 | ||||||
MIRT003124 | Ccng1 | cyclin G1 | ![]() |
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2 | 1 | ||||||
MIRT003125 | Slc7a1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | ![]() |
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3 | 3 | |||||
MIRT003126 | Gys1 | glycogen synthase 1, muscle | ![]() |
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2 | 2 | ||||||
MIRT003127 | Slc35a4 | solute carrier family 35, member A4 | ![]() |
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2 | 2 | ||||||
MIRT003128 | Hfe2 | hemochromatosis type 2 (juvenile) | ![]() |
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3 | 3 | |||||
MIRT003129 | Tmed3 | transmembrane p24 trafficking protein 3 | ![]() |
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2 | 2 | ||||||
MIRT003132 | Bckdk | branched chain ketoacid dehydrogenase kinase | ![]() |
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4 | 1 | ||||
MIRT003133 | Aldoa | aldolase A, fructose-bisphosphate | ![]() |
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4 | 7 | ||||
MIRT003134 | Ndrg3 | N-myc downstream regulated gene 3 | ![]() |
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4 | 2 | ||||
MIRT003135 | Cd320 | CD320 antigen | ![]() |
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4 | 1 | ||||
MIRT003724 | Smarcd1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 | ![]() |
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3 | 1 | |||||
MIRT003725 | Rcan1 | regulator of calcineurin 1 | ![]() |
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2 | 1 | ||||||
MIRT003726 | Gde1 | glycerophosphodiester phosphodiesterase 1 | ![]() |
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2 | 1 | ||||||
MIRT004536 | Ccrn4l | nocturnin | ![]() |
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4 | 1 | ||||
MIRT005975 | Klf6 | Kruppel-like factor 6 | ![]() |
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4 | 1 | ||||
MIRT005976 | B2m | beta-2 microglobulin | ![]() |
1 | 1 | |||||||
MIRT005977 | Afp | alpha fetoprotein | ![]() |
1 | 1 | |||||||
MIRT005978 | Ccl2 | chemokine (C-C motif) ligand 2 | ![]() |
1 | 1 | |||||||
MIRT005979 | Csf3r | colony stimulating factor 3 receptor (granulocyte) | ![]() |
1 | 1 | |||||||
MIRT005980 | Ctgf | connective tissue growth factor | ![]() |
1 | 1 | |||||||
MIRT005981 | Cxcl13 | chemokine (C-X-C motif) ligand 13 | ![]() |
1 | 1 | |||||||
MIRT005982 | Cyp2b13 | cytochrome P450, family 2, subfamily b, polypeptide 13 | ![]() |
1 | 1 | |||||||
MIRT005983 | Dbp | D site albumin promoter binding protein | ![]() |
1 | 1 | |||||||
MIRT005984 | Igf2 | insulin-like growth factor 2 | ![]() |
1 | 1 | |||||||
MIRT005985 | Il1b | interleukin 1 beta | ![]() |
1 | 1 | |||||||
MIRT005986 | Jun | jun proto-oncogene | ![]() |
1 | 1 | |||||||
MIRT005987 | Per1 | period circadian clock 1 | ![]() |
1 | 1 | |||||||
MIRT005988 | Alpl | alkaline phosphatase, liver/bone/kidney | ![]() |
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2 | 1 | ||||||
MIRT005989 | Cs | citrate synthase | ![]() |
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2 | 1 | ||||||
MIRT005990 | Prom1 | prominin 1 | ![]() |
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3 | 1 | |||||
MIRT005991 | Sox4 | SRY (sex determining region Y)-box 4 | ![]() |
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3 | 1 | |||||
MIRT013527 | Uros | uroporphyrinogen III synthase | ![]() |
1 | 1 | |||||||
MIRT013528 | Ppox | protoporphyrinogen oxidase | ![]() |
1 | 1 | |||||||
MIRT013529 | Urod | uroporphyrinogen decarboxylase | ![]() |
1 | 1 | |||||||
MIRT013530 | Cpox | coproporphyrinogen oxidase | ![]() |
1 | 1 | |||||||
MIRT013531 | Fech | ferrochelatase | ![]() |
1 | 1 | |||||||
MIRT013532 | Hamp | hepcidin antimicrobial peptide | ![]() |
1 | 1 | |||||||
MIRT013533 | Tfr2 | transferrin receptor 2 | ![]() |
1 | 1 | |||||||
MIRT013534 | Smad4 | SMAD family member 4 | ![]() |
1 | 1 | |||||||
MIRT013535 | Smad7 | SMAD family member 7 | ![]() |
1 | 1 | |||||||
MIRT013536 | Bmpr1a | bone morphogenetic protein receptor, type 1A | ![]() |
1 | 1 | |||||||
MIRT013537 | Hba-a1 | hemoglobin alpha, adult chain 1 | ![]() |
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2 | 1 | ||||||
MIRT013538 | Hmbs | hydroxymethylbilane synthase | ![]() |
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2 | 1 | ||||||
MIRT013539 | Mir17 | microRNA 17 | ![]() |
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2 | 1 | ||||||
MIRT013540 | Alas2 | aminolevulinic acid synthase 2, erythroid | ![]() |
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2 | 1 | ||||||
MIRT013541 | Mir451 | microRNA 451a | ![]() |
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2 | 1 | ||||||
MIRT013542 | Tfrc | transferrin receptor | ![]() |
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2 | 1 | ||||||
MIRT013543 | Socs2 | suppressor of cytokine signaling 2 | ![]() |
1 | 1 | |||||||
MIRT013544 | Slc35g1 | solute carrier family 35, member G1 | ![]() |
1 | 1 | |||||||
MIRT013545 | Camk2b | calcium/calmodulin-dependent protein kinase II, beta | ![]() |
1 | 1 | |||||||
MIRT013546 | Irf6 | interferon regulatory factor 6 | ![]() |
1 | 1 | |||||||
MIRT013547 | Rbl2 | RB transcriptional corepressor like 2 | ![]() |
1 | 1 | |||||||
MIRT013548 | Hfe | hemochromatosis | ![]() |
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2 | 1 | ||||||
MIRT013549 | Ccnd1 | cyclin D1 | ![]() |
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2 | 1 | ||||||
MIRT054338 | Pkm | pyruvate kinase, muscle | ![]() |
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3 | 1 | |||||
MIRT054339 | Tfdp2 | transcription factor Dp 2 | ![]() |
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3 | 1 | |||||
MIRT054340 | E2f1 | E2F transcription factor 1 | ![]() |
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3 | 1 | |||||
MIRT579817 | Zfp113 | zinc finger protein 113 | ![]() |
1 | 1 | |||||||
MIRT580378 | Tmem206 | transmembrane protein 206 | ![]() |
1 | 2 | |||||||
MIRT581166 | Sec23ip | Sec23 interacting protein | ![]() |
1 | 1 | |||||||
MIRT582514 | March5 | membrane-associated ring finger (C3HC4) 5 | ![]() |
1 | 2 | |||||||
MIRT586941 | H2-T24 | histocompatibility 2, T region locus 24 | ![]() |
1 | 2 | |||||||
MIRT591859 | Iffo2 | intermediate filament family orphan 2 | ![]() |
1 | 1 | |||||||
MIRT592160 | Paxip1 | PAX interacting (with transcription-activation domain) protein 1 | ![]() |
1 | 1 | |||||||
MIRT592189 | Nanog | Nanog homeobox | ![]() |
1 | 2 | |||||||
MIRT592792 | Cdh12 | cadherin 12 | ![]() |
1 | 1 | |||||||
MIRT597026 | Thap1 | THAP domain containing, apoptosis associated protein 1 | ![]() |
1 | 1 | |||||||
MIRT597210 | Snhg11 | small nucleolar RNA host gene 11 | ![]() |
1 | 1 | |||||||
MIRT601300 | Zfp949 | zinc finger protein 949 | ![]() |
1 | 1 | |||||||
MIRT602608 | Chrna1 | cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) | ![]() |
1 | 1 | |||||||
MIRT602960 | Xpo7 | exportin 7 | ![]() |
1 | 1 | |||||||
MIRT603391 | Sgol2 | shugoshin 2A | ![]() |
1 | 1 | |||||||
MIRT604008 | Ggps1 | geranylgeranyl diphosphate synthase 1 | ![]() |
1 | 1 | |||||||
MIRT605553 | Ppp1r16b | protein phosphatase 1, regulatory (inhibitor) subunit 16B | ![]() |
1 | 1 | |||||||
MIRT606204 | Sfxn4 | sideroflexin 4 | ![]() |
1 | 1 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||
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