miRTarBase - #MIRT016137


—
pre-miRNA Information
pre-miRNA hsa-mir-449b   
Genomic Coordinates chr5: 55170646 - 55170742
Description Homo sapiens miR-449b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-449b-5p
Sequence 16| AGGCAGUGUAUUGUUAGCUGGC |37
Evidence Experimental
Experiments Microarray
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN8871076 12 COSMIC
COSN17153496 22 COSMIC
COSN31576772 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322925717 3 dbSNP
rs769526811 10 dbSNP
rs10061133 12 dbSNP
rs1431829587 13 dbSNP
rs778042202 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CDK4   
Synonyms CMM3, PSK-J3
Description cyclin dependent kinase 4
Transcript NM_000075   
Expression
Putative miRNA Targets on CDK4
3'UTR of CDK4
(miRNA target sites are highlighted)		 
>CDK4|NM_000075|3'UTR
   1 GCAATGGAGTGGCTGCCATGGAAGGAAGAAAAGCTGCCATTTCCCTTCTGGACACTGAGAGGGCAATCTTTGCCTTTATC
  81 TCTGAGGCTATGGAGGGTCCTCCTCCATCTTTCTACAGAGATTACTTTGCTGCCTTAATGACATTCCCCTCCCACCTCTC
 161 CTTTTGAGGCTTCTCCTTCTCCTTCCCATTTCTCTACACTAAGGGGTATGTTCCCTCTTGTCCCTTTCCCTACCTTTATA
 241 TTTGGGGTCCTTTTTTATACAGGAAAAACAAAACAAAGAAATAATGGTCTTTTTTTTTTTTTTAATGTTTCTTCCTCTGT
 321 TTGGCTTTGCCATTGTGCGATTTGGAAAAACCACTTGGAAGAAGGGACTTTCCTGCAAAACCTTAAAGACTGGTTAAATT
 401 ACAGGGCCTAGGAAGTCAGTGGAGCCCCTTGACTGACAAAGCTTAGAAAGGAACTGAAATTGCTTCTTTGAATATGGATT
 481 TTAGGCGGGGCGTGGTGGCTCACGCCTATAATCCCAGCACGTTGGGAGGCCAACGCGGGTGGATCACCTGAGGTCAGGAG
 561 TTCGAGACCAGCCTGACTAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAATTAGTCAGGCGTGGTGGTGCACACC
 641 TGTAATCCCAGCTACTTGGGAGACTGAGGCAGGAGGATCGCTTGAACCCGGGAGGCAGAGGTTGCGGTGAGCCGAGATCA
 721 TGCCATTGCACTCCAGCCTGGGCAACAGAGCAAGACTCTGTGTCAAAAAAAAAAAAAGAATATAGATTTTTAAATGGCAA
 801 AAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgGUCGAUUGUUAUGUGACGGa 5'
            |||  | :| | ::||||| 
Target 5' taCAGAGATTACTTTGCTGCCt 3'
 114 - 135 124.00 -12.10
2 
miRNA  3' cggUCGAUUGU--UAU-GUGACGga 5'
             ||| :| |  ||: ||:|||  
Target 5' gtgAGCCGAGATCATGCCATTGCac 3'
 707 - 731 117.00 -11.50
3 
miRNA  3' cggucGAUUGU-----UAUGUGACGGa 5'
               ||||||     | || |||:| 
Target 5' cctgaCTAACATGGTGAAACCCTGTCt 3'
 572 - 598 113.00 -12.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
188065 5 ClinVar
384740 12 ClinVar
309977 210 ClinVar
309976 246 ClinVar
884129 271 ClinVar
309974 304 ClinVar
309975 304 ClinVar
309973 319 ClinVar
884128 333 ClinVar
309972 370 ClinVar
882420 424 ClinVar
309971 437 ClinVar
309970 479 ClinVar
309969 491 ClinVar
309968 521 ClinVar
309967 689 ClinVar
309966 690 ClinVar
309965 706 ClinVar
882173 734 ClinVar
882172 751 ClinVar
309964 764 ClinVar
309963 778 ClinVar
COSN31597858 16 COSMIC
COSN30504077 21 COSMIC
COSN30514110 30 COSMIC
COSN30481994 43 COSMIC
COSN27000280 56 COSMIC
COSN30140215 59 COSMIC
COSN13410063 63 COSMIC
COSN30514804 74 COSMIC
COSN30698275 100 COSMIC
COSN30155601 166 COSMIC
COSN30511504 171 COSMIC
COSN31542388 278 COSMIC
COSN26637072 330 COSMIC
COSN31565159 380 COSMIC
COSN32010263 489 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs786204045 5 dbSNP
rs1196923268 9 dbSNP
rs770044583 12 dbSNP
rs1191724475 14 dbSNP
rs748223579 16 dbSNP
rs1225004491 17 dbSNP
rs373442519 18 dbSNP
rs1172367214 19 dbSNP
rs754876640 23 dbSNP
rs1315410858 28 dbSNP
rs746950724 31 dbSNP
rs779845928 33 dbSNP
rs1309022049 35 dbSNP
rs1017192884 40 dbSNP
rs2069510 44 dbSNP
rs1460605718 48 dbSNP
rs758102242 50 dbSNP
rs1323224963 57 dbSNP
rs1396066642 66 dbSNP
rs982854686 72 dbSNP
rs1294675919 93 dbSNP
rs951446771 96 dbSNP
rs1221509321 107 dbSNP
rs1029790530 108 dbSNP
rs1395127864 115 dbSNP
rs1489692361 125 dbSNP
rs1293552957 128 dbSNP
rs573865135 133 dbSNP
rs1280507408 134 dbSNP
rs1042890478 137 dbSNP
rs1246031626 150 dbSNP
rs555555387 157 dbSNP
rs899861787 158 dbSNP
rs1271298523 181 dbSNP
rs1352426983 188 dbSNP
rs1323632337 191 dbSNP
rs187207546 193 dbSNP
rs1241728307 197 dbSNP
rs1000870693 203 dbSNP
rs1336872901 209 dbSNP
rs2069511 210 dbSNP
rs563404067 214 dbSNP
rs890445351 221 dbSNP
rs1367654009 224 dbSNP
rs1304056687 231 dbSNP
rs1415298343 236 dbSNP
rs763088789 246 dbSNP
rs1166097174 247 dbSNP
rs775148859 253 dbSNP
rs1429246268 257 dbSNP
rs1300396808 270 dbSNP
rs1051806760 271 dbSNP
rs3180722 274 dbSNP
rs1160378757 276 dbSNP
rs3179899 278 dbSNP
rs929538327 282 dbSNP
rs1471098856 286 dbSNP
rs1291708445 290 dbSNP
rs1381424006 291 dbSNP
rs945105324 292 dbSNP
rs1198394660 294 dbSNP
rs1283666175 299 dbSNP
rs3180723 303 dbSNP
rs1238908150 304 dbSNP
rs1314984297 304 dbSNP
rs372480061 304 dbSNP
rs59185470 304 dbSNP
rs78419156 304 dbSNP
rs886049711 304 dbSNP
rs886049712 304 dbSNP
rs1479356346 305 dbSNP
rs1472931647 306 dbSNP
rs1270587986 307 dbSNP
rs917883102 311 dbSNP
rs1446078911 314 dbSNP
rs1418358557 315 dbSNP
rs1161024667 319 dbSNP
rs775370483 319 dbSNP
rs1206405976 324 dbSNP
rs1434560470 324 dbSNP
rs1332419296 332 dbSNP
rs199606572 333 dbSNP
rs942188819 338 dbSNP
rs1274823483 339 dbSNP
rs1371301661 351 dbSNP
rs1475994409 354 dbSNP
rs1242194964 358 dbSNP
rs1309932398 362 dbSNP
rs1222065344 364 dbSNP
rs59273640 369 dbSNP
rs3473 370 dbSNP
rs990566844 372 dbSNP
rs1442604082 375 dbSNP
rs1056173330 381 dbSNP
rs1203405595 390 dbSNP
rs1230656395 394 dbSNP
rs939004598 397 dbSNP
rs926312287 424 dbSNP
rs1441045730 425 dbSNP
rs980685431 429 dbSNP
rs1381537920 433 dbSNP
rs3472 437 dbSNP
rs3211635 440 dbSNP
rs1048066 446 dbSNP
rs1404835029 466 dbSNP
rs1415205961 468 dbSNP
rs1328488290 473 dbSNP
rs1398159443 474 dbSNP
rs1449170919 475 dbSNP
rs1332147070 477 dbSNP
rs886049710 479 dbSNP
rs746139891 486 dbSNP
rs1034639609 487 dbSNP
rs112275916 491 dbSNP
rs983020823 492 dbSNP
rs966350391 497 dbSNP
rs1175702457 499 dbSNP
rs529424415 503 dbSNP
rs1431080377 504 dbSNP
rs190042114 508 dbSNP
rs1199883561 515 dbSNP
rs1474852876 520 dbSNP
rs113625101 521 dbSNP
rs549179019 522 dbSNP
rs1379709674 524 dbSNP
rs1478581811 528 dbSNP
rs1167548837 533 dbSNP
rs747329158 534 dbSNP
rs964014218 535 dbSNP
rs1447145497 537 dbSNP
rs186719311 546 dbSNP
rs1000416664 563 dbSNP
rs560181586 564 dbSNP
rs1331469318 572 dbSNP
rs778454087 591 dbSNP
rs1276085061 601 dbSNP
rs1319478688 604 dbSNP
rs1218893316 612 dbSNP
rs1010348804 617 dbSNP
rs1271930470 618 dbSNP
rs545299499 625 dbSNP
rs774948009 626 dbSNP
rs1337672390 635 dbSNP
rs1452710930 652 dbSNP
rs1192843590 657 dbSNP
rs1261522786 675 dbSNP
rs1272188263 676 dbSNP
rs890580623 678 dbSNP
rs1051857809 679 dbSNP
rs1340006761 680 dbSNP
rs1456515519 684 dbSNP
rs1334802187 685 dbSNP
rs886049709 689 dbSNP
rs886049708 690 dbSNP
rs904823018 700 dbSNP
rs1037928322 701 dbSNP
rs942299991 702 dbSNP
rs1045132515 705 dbSNP
rs184712 706 dbSNP
rs1409203233 710 dbSNP
rs1246420268 713 dbSNP
rs1056401055 714 dbSNP
rs938859233 719 dbSNP
rs909780892 724 dbSNP
rs184047546 733 dbSNP
rs1047001789 734 dbSNP
rs1194650649 740 dbSNP
rs1257152369 743 dbSNP
rs1475547553 748 dbSNP
rs192347082 751 dbSNP
rs1181253656 756 dbSNP
rs966319292 761 dbSNP
rs866662376 763 dbSNP
rs1156825828 764 dbSNP
rs886049707 764 dbSNP
rs79045565 766 dbSNP
rs573384320 772 dbSNP
rs1204229635 774 dbSNP
rs1362179846 777 dbSNP
rs1311879820 778 dbSNP
rs146863045 778 dbSNP
rs374953569 778 dbSNP
rs886049706 778 dbSNP
rs989396191 778 dbSNP
rs1312754391 780 dbSNP
rs958236270 782 dbSNP
rs1306187762 783 dbSNP
rs2859601 787 dbSNP
rs1240017737 790 dbSNP
Experimental Support 1 for Non-Functional miRNA-Target Interaction
miRNA:Target xx
Validation Method
Article - Yang X; Feng M; Jiang X; Wu Z; Li Z; Aau M; Yu Q
- Genes & development, 2009
The Rb-E2F pathway drives cell cycle progression and cell proliferation, and the molecular strategies safeguarding its activity are not fully understood. Here we report that E2F1 directly transactivates miR-449a/b. miR-449a/b targets and inhibits oncogenic CDK6 and CDC25A, resulting in pRb dephosphorylation and cell cycle arrest at G1 phase, revealing a negative feedback regulation of the pRb-E2F1 pathway. Moreover, miR-449a/b expression in cancer cells is epigenetically repressed through histone H3 Lys27 trimethylation, and epigenetic drug treatment targeting histone methylation results in strong induction of miR-449a/b. Our study reveals a tumor suppressor function of miR-449a/b through regulating Rb/E2F1 activity, and suggests that escape from this regulation through an aberrant epigenetic event contributes to E2F1 deregulation and unrestricted proliferation in human cancer.
LinkOut: [PMID: 19833767]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.748 1.6e-3 -0.747 1.7e-3 13 Click to see details
GSE21687 Ependynoma primary tumors -0.324 4.5e-3 -0.277 1.3e-2 64 Click to see details
GSE42095 Differentiated embryonic stem cells -0.475 1.1e-2 -0.667 2.5e-4 23 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.764 1.4e-2 0.762 1.4e-2 8 Click to see details
GSE14794 Lymphoblastoid cells -0.162 6.4e-2 -0.217 2.0e-2 90 Click to see details
GSE19536 Breast cancer -0.143 7.8e-2 -0.087 1.9e-1 100 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.328 7.9e-2 0.681 4.7e-4 20 Click to see details
GSE32688 Pancreatic cancer -0.243 9.0e-2 -0.343 2.7e-2 32 Click to see details
GSE38226 Liver fibrosis 0.302 9.2e-2 0.095 3.4e-1 21 Click to see details
GSE19783 ER+ ER+ breast cancer -0.226 1.7e-1 -0.035 4.4e-1 20 Click to see details
GSE19783 ER- ER- breast cancer -0.094 2.0e-1 -0.044 3.5e-1 79 Click to see details
GSE17306 Multiple myeloma -0.116 2.1e-1 -0.002 4.9e-1 49 Click to see details
GSE17498 Multiple myeloma -0.126 2.2e-1 -0.008 4.8e-1 40 Click to see details
GSE21849 B cell lymphoma -0.148 2.2e-1 -0.141 2.3e-1 29 Click to see details
GSE26953 Aortic valvular endothelial cells -0.095 3.3e-1 -0.121 2.9e-1 24 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.072 3.7e-1 -0.035 4.3e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.051 4.0e-1 -0.040 4.2e-1 25 Click to see details
GSE19350 CNS germ cell tumors -0.078 4.0e-1 -0.070 4.1e-1 12 Click to see details
GSE27834 Pluripotent stem cells -0.044 4.4e-1 -0.106 3.5e-1 16 Click to see details
GSE28544 Breast cancer 0.03 4.4e-1 0.024 4.6e-1 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA 0.996 0.03 1.000 0.5 3 Click to see details
BRCA 0.704 0.15 0.800 0.1 4 Click to see details
LUSC -0.322 0.34 -0.200 0.4 4 Click to see details
UCEC 0.028 0.47 -0.048 0.46 8 Click to see details
UCEC 0.028 0.47 -0.048 0.46 8 Click to see details
UCEC 0.028 0.47 -0.048 0.46 8 Click to see details
UCEC 0.028 0.47 -0.048 0.46 8 Click to see details
UCEC 0.028 0.47 -0.048 0.46 8 Click to see details
109 hsa-miR-449b-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006349 SIRT1 sirtuin 1 2 1
MIRT006350 CCNE2 cyclin E2 4 3
MIRT006351 MET MET proto-oncogene, receptor tyrosine kinase 2 1
MIRT006352 GMNN geminin, DNA replication inhibitor 2 1
MIRT006353 HDAC1 histone deacetylase 1 2 1
MIRT016137 CDK4 cyclin dependent kinase 4 1 1
MIRT016138 CDC25A cell division cycle 25A 2 1
MIRT016139 CDK6 cyclin dependent kinase 6 4 3
MIRT057740 ZDHHC16 zinc finger DHHC-type containing 16 2 2
MIRT078636 FAM104A family with sequence similarity 104 member A 2 2
MIRT100407 HSPA1B heat shock protein family A (Hsp70) member 1B 2 2
MIRT115552 MAZ MYC associated zinc finger protein 2 2
MIRT130146 TXNIP thioredoxin interacting protein 2 4
MIRT142254 DCTN5 dynactin subunit 5 2 2
MIRT143724 CCL22 C-C motif chemokine ligand 22 2 2
MIRT168101 E2F3 E2F transcription factor 3 2 2
MIRT169809 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT183694 MDM4 MDM4, p53 regulator 2 2
MIRT198922 SMAD4 SMAD family member 4 2 2
MIRT202950 TSN translin 2 4
MIRT221565 CBX3 chromobox 3 2 2
MIRT253418 EVI5L ecotropic viral integration site 5 like 2 2
MIRT294759 ZNF551 zinc finger protein 551 2 4
MIRT307053 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT331273 TM9SF3 transmembrane 9 superfamily member 3 2 6
MIRT372293 UBXN2B UBX domain protein 2B 2 2
MIRT374317 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT445817 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT447158 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT447823 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448798 GMFB glia maturation factor beta 2 2
MIRT451580 HIRIP3 HIRA interacting protein 3 2 2
MIRT452679 GPR156 G protein-coupled receptor 156 2 2
MIRT453158 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT453634 SLC4A2 solute carrier family 4 member 2 2 2
MIRT455384 PLA2G2D phospholipase A2 group IID 2 2
MIRT456958 SPAM1 sperm adhesion molecule 1 2 2
MIRT462739 EFNB1 ephrin B1 2 2
MIRT464321 UST uronyl 2-sulfotransferase 2 2
MIRT465641 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT466748 SYNGR2 synaptogyrin 2 2 2
MIRT468345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT469324 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT474361 KMT2D lysine methyltransferase 2D 2 2
MIRT475316 IFNLR1 interferon lambda receptor 1 2 2
MIRT477759 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT477824 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478265 DDX19B DEAD-box helicase 19B 2 2
MIRT481042 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT481289 ATXN1L ataxin 1 like 2 2
MIRT482730 COPZ1 coatomer protein complex subunit zeta 1 2 2
MIRT488780 CYTH3 cytohesin 3 2 2
MIRT489578 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489659 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT490527 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT492949 NEUROD2 neuronal differentiation 2 2 2
MIRT493154 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT493845 FOXN3 forkhead box N3 2 4
MIRT494743 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT496491 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT503312 FICD FIC domain containing 2 4
MIRT503507 ZNF623 zinc finger protein 623 2 2
MIRT504182 FAM127B retrotransposon Gag like 8A 2 2
MIRT505010 ZNF644 zinc finger protein 644 2 2
MIRT505352 TMEM167A transmembrane protein 167A 2 2
MIRT505645 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT505710 SESN2 sestrin 2 2 2
MIRT505777 SATB2 SATB homeobox 2 2 6
MIRT506208 PHF19 PHD finger protein 19 2 2
MIRT506251 PEG10 paternally expressed 10 2 2
MIRT507786 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT508005 BCL2L13 BCL2 like 13 2 4
MIRT508857 ZRSR1 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1 2 4
MIRT510546 XBP1P1 X-box binding protein 1 pseudogene 1 2 4
MIRT511892 GAS1 growth arrest specific 1 2 6
MIRT512907 UBL4A ubiquitin like 4A 2 2
MIRT513600 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT521241 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT521321 RRAGD Ras related GTP binding D 2 4
MIRT525281 C18orf32 chromosome 18 open reading frame 32 2 2
MIRT528650 RWDD2A RWD domain containing 2A 2 4
MIRT535101 PODXL podocalyxin like 2 2
MIRT547752 KBTBD6 kelch repeat and BTB domain containing 6 2 4
MIRT547865 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT549170 BMP3 bone morphogenetic protein 3 2 2
MIRT550115 SLC35G2 solute carrier family 35 member G2 2 2
MIRT556097 MOAP1 modulator of apoptosis 1 2 2
MIRT557172 HOXA13 homeobox A13 2 2
MIRT557422 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT557931 FAM73A mitoguardin 1 2 2
MIRT568804 VPS37D VPS37D, ESCRT-I subunit 2 2
MIRT571326 TPCN2 two pore segment channel 2 2 2
MIRT572598 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT573437 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT574092 VASN vasorin 2 2
MIRT608688 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT608800 ITGA11 integrin subunit alpha 11 2 4
MIRT610332 SSX5 SSX family member 5 2 2
MIRT613158 DDA1 DET1 and DDB1 associated 1 2 2
MIRT625407 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT636603 CLIC5 chloride intracellular channel 5 2 2
MIRT638573 IER5 immediate early response 5 2 2
MIRT639686 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT677979 ITGB3 integrin subunit beta 3 2 2
MIRT685217 POTED POTE ankyrin domain family member D 2 2
MIRT702570 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT706259 MKLN1 muskelin 1 2 2
MIRT734675 HMGB1 high mobility group box 1 3 0
MIRT736369 HSPA1A heat shock protein family A (Hsp70) member 1A 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-449b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-449b Doxorubicin approved 31703 Quantitative real-time PCR ovarian carcinoma cell line A2780 cells 22340095 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SUIT-2, CAPAN-1)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Panobinostat 6918837 NSC761190 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-449b-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (HeyA8)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-449b-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

Error report submission