miRTarBase - #MIRT021695


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pre-miRNA Information
pre-miRNA hsa-mir-133a-1   
Genomic Coordinates chr18: 21825698 - 21825785
Synonyms MIRN133A1, MIR133A1
Description Homo sapiens miR-133a-1 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-133a-2   
Genomic Coordinates chr20: 62564912 - 62565013
Synonyms MIRN133A2, MIR133A2
Description Homo sapiens miR-133a-2 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-133a-3p
Sequence 53| UUUGGUCCCCUUCAACCAGCUG |74
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30104664 8 COSMIC
COSN30455205 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369575411 9 dbSNP
rs746815210 11 dbSNP
rs1382873526 13 dbSNP
rs553267926 15 dbSNP
rs1172821195 16 dbSNP
rs182673735 19 dbSNP
rs781929120 20 dbSNP
rs1296628341 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma .
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Muscle Reverse transcription-polymerase chain reaction
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma Real-time reverse transcription PCR
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Serum Real-time polymerase chain reaction
Gene Information
Gene Symbol FBN1   
Synonyms ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFLS, MFS1, OCTD, SGS, SSKS, WMS, WMS2
Description fibrillin 1
Transcript NM_000138   
Expression
Putative miRNA Targets on FBN1
3'UTR of FBN1
(miRNA target sites are highlighted)		 
>FBN1|NM_000138|3'UTR
   1 TTCACCATCCAGAGACCAAATAATTAAAAGAAAAACAAATATAGATAGGTAGAACTATATTTTCCCCCAATCAGAATCAT
  81 CATATCATAGGTACAATCTTTCACCAAGTAAATTTGTATAAATAAGCACTATTCTTTGTATTACCAAAGCAAGGTACAGG
 161 TGACTACCCTAGTTCAAAACAACCACTTTCTCAGGCTTCTCATGTGTGTAGCTAAGCTACCTTGTCATATGTGTTGATTC
 241 TTGAAAACTGGGACGTGTATTTCCATTGGGGGTTGGCCATTTATGCTGACATGCCATCCTTCCAGCAAACGTACGGGAAT
 321 GTGCTTTCAATTGATGGACTACTCTATTTTTTGCAAATTTGTAAACTTTGCTTCTCCAAATACAAGTACTAGGTTGTCCA
 401 TTTATGGTACCTATTTGGTGCTAGTAAATTTTCAAACTAGATTTATAAATGCACTGTAATATGTACACAACTTAGAAACC
 481 AAATTACAAGTATTCAGTTCCAATACTTCATTAATTTCAATCAACCAAAGTTAGTTCAGTAGCTTATCTCAGTTATGAGT
 561 ATAATACATTACATGTAAATTAAGTGTGTGTATACTGTAATCGTGCTATTTTTTATCATTGAAACATTTATAAACTAGAA
 641 TAATAATGCCCTTAATGTGAGGGTTTGTAATGGTGCTTATTAAGACCAAAGACTTGTTAAATGTATACACCAAGTGGTAA
 721 TGAAATTTCGGTGACTGGCCCACACGTGCATAGAGGTCTGGGAGGACCAGGAAACAGCCTCAGTGGCCAGAGGATCACCA
 801 GTGCATCCTTCATCACAGCATGTGCAATATGCCAAGATTACCCTCGGTCATTCCTGTCAACAAGGGGTCAATGTCATAAA
 881 TGTCACAATAAAACAATCTCTTCTTTTTTTTAGTTTACCCCTTGGCTTTGTGTTCTTGCATGGATTTGGGGTTGGAGGGG
 961 CCATTCCGGAGGCTAAATAAAGTCTCCTGGATTTAAATTATCCTGGGTCTCTTACTTATGGCTTATGAAAGTACCAAATG
1041 TATAACCACTAGAAGAAAATTTAACATATGAGTCGATCCCTTGTTTTATCCATTGAAAGTAGCAGAGTCTGGTGTCATTA
1121 ACCTGACTTGCTTGTGAGAAATTTAGATTGTAGAGTCATTTCTGAAACATGACCTAATTCATCTTGTGACTTTTAAATAG
1201 TCTTAAATACCAAGTTCAGTCATTGTCTTAGAGCACATGAATTTCATTATAATAGATTTATCATGCCCCCCTCTCAAATA
1281 TACACAGTTTTGGCAAGCCTTAGGTGTTCTGTTCCATTTTTTTTTCCCCTAAACATCTTTCGTTAGTCAATGCTCATCTA
1361 ATTACAAAGGGATAATCCCAGACTGTATCCAATTGCTGTAACTTTTGGTTTCTTAATGTCATAATTTTTAAAGTCTGTTT
1441 TATTTTAAGTGCAATATTGAGTATTTAGCTGTTAGGCTCAATCCGTCGATATGAAATAATTTTTTAAATCCCTAAGGGCA
1521 GGAAAGCATTTCGTGGTAGTGAAAATAAGAGGAAATAAGATGGCATGAAGGTGGTGGGCGGAGAAACTAGGTAGGACACA
1601 GGAAAGTGCTCTCAAAAATCTTTGAAGAGCTCAGCTGAAAAAAATGGAGTAGATTTGGCTCATACTATTCCGGAAGGCAA
1681 AACCAGGGTCAGCTGATGTCAGCCCCAGTTTAATACACACGGTCCCAATTATAGAGCTACTCACTGAAAGAATGGGTTTC
1761 CTTGCATTGTGGTGAGCTCCCTGTCACAAGATAGAAGAGTTTCAGTCTAGGCTTAATGGCAACCATTGGACAAAGATGCT
1841 TTCTTCCACCTAACAGGCCATTAACATCTTAAAGGTATTTTTGTATCTCTAATTTTGTTTATAATAGGTGCTCAACAGAA
1921 TGAGCTGAATGGCTGTTACAAAGGGGGTTTGTACCTTGGGTAAGAGATTAAAATATAACTCAAAATTTCCTTCTAACGCT
2001 GCACCTATGGAACCATGTGATAGAGGTGTATTAAAATTGTTATCGAAGAATATATAGCATATGGTAAACAACAGTTTGCA
2081 TATGGAAAATGTCTTTGATAATTTAACCAGAACTGCATTATATTCAATAACGGATTTTCTTTATAACAAACAACAGGGGA
2161 AAATGGAGTTGGCACACAGTGGATCACTTTGATATTTTTAATAGTCCAAGTCTGGATTTTATTTATTCCTGAGCCAACAA
2241 TTTTGAACAGCATATTTTCCATGTTTCTGACTGTAACAAAACATTTTCCTCATTGTTCCATTGTAAATATTCCTCTTGTT
2321 GGAACTCTTTTTAATCCTGAGATTTAAACCTGTACCTTTCAATTGTCTGTGACCTTTCAATTTCACTTTCAATAGTTGAA
2401 GAACTTGGCTTTGTAAATCTCTCAGAAGCTTGAAAATATCTTGTCTCTACCCCCTCAGCCCATTTCATTTGCCAATAATT
2481 ATTTTGTAAGTAGGGTTGAAATGAACTCAGCTGGCCTTGTGAAATGTTTAAACTTGCACAAACAACTACATTTTTGTTCA
2561 ACAAATAGCAGTTTACTCAGCCAAAATCACTTTGGATATTGCCATTACAAATACTGTTAAACTTCAGAAATCATGTCTGT
2641 AAATTAGATGAGCCAAAATAAAGGACAATTGGGTTGATGCTGCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gucgaCCAACUUCCCCUGGUUu 5'
               |||  ::| ||||||: 
Target 5' atagaGGTCTGGGAGGACCAGg 3'
 750 - 771 137.00 -18.70
2 
miRNA  3' gucgaCCAACUUCCCCUGGUuu 5'
               |||||:| |||:|||  
Target 5' tttggGGTTGGA-GGGGCCAtt 3'
 945 - 965 132.00 -23.60
3 
miRNA  3' guCGACCAACUUCCCCUGGUUu 5'
            |||  || ||   |||||| 
Target 5' gtGCTTATT-AA---GACCAAa 3'
 673 - 690 123.00 -7.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
888468 43 ClinVar
316359 57 ClinVar
886213 107 ClinVar
316358 204 ClinVar
885309 235 ClinVar
885308 252 ClinVar
888414 253 ClinVar
316357 254 ClinVar
316356 268 ClinVar
316355 286 ClinVar
885246 300 ClinVar
885245 311 ClinVar
316354 314 ClinVar
886075 325 ClinVar
886074 399 ClinVar
316353 406 ClinVar
316352 724 ClinVar
316351 730 ClinVar
316350 764 ClinVar
885096 779 ClinVar
885095 845 ClinVar
316349 867 ClinVar
316348 938 ClinVar
316347 948 ClinVar
316346 961 ClinVar
316345 967 ClinVar
885033 968 ClinVar
316344 987 ClinVar
316343 1007 ClinVar
316342 1084 ClinVar
888152 1122 ClinVar
886871 1201 ClinVar
316341 1228 ClinVar
316340 1245 ClinVar
884967 1249 ClinVar
316339 1252 ClinVar
316338 1298 ClinVar
316337 1325 ClinVar
884892 1341 ClinVar
316336 1368 ClinVar
888017 1375 ClinVar
316335 1396 ClinVar
316334 1398 ClinVar
885745 1432 ClinVar
316333 1437 ClinVar
316332 1477 ClinVar
316331 1484 ClinVar
316330 1562 ClinVar
316329 1575 ClinVar
316328 1580 ClinVar
316327 1619 ClinVar
316326 1635 ClinVar
316325 1672 ClinVar
316324 1706 ClinVar
316323 1720 ClinVar
316322 1733 ClinVar
316321 1943 ClinVar
316320 1949 ClinVar
316319 1951 ClinVar
316318 1959 ClinVar
884680 1981 ClinVar
316317 1989 ClinVar
316316 2024 ClinVar
886579 2037 ClinVar
316315 2040 ClinVar
884620 2044 ClinVar
884619 2045 ClinVar
316314 2078 ClinVar
316313 2091 ClinVar
316312 2114 ClinVar
316311 2153 ClinVar
316310 2158 ClinVar
316309 2221 ClinVar
316308 2260 ClinVar
316307 2360 ClinVar
316306 2395 ClinVar
316305 2398 ClinVar
316304 2421 ClinVar
316303 2443 ClinVar
316302 2524 ClinVar
316301 2533 ClinVar
316300 2556 ClinVar
316299 2578 ClinVar
887646 2592 ClinVar
316298 2594 ClinVar
316297 2638 ClinVar
316296 2674 ClinVar
COSN30161704 9 COSMIC
COSN508227 19 COSMIC
COSN30144789 24 COSMIC
COSN30109518 25 COSMIC
COSN31612073 30 COSMIC
COSN30135760 77 COSMIC
COSN13624973 98 COSMIC
COSN13624972 107 COSMIC
COSN31580447 134 COSMIC
COSN31557771 190 COSMIC
COSN16526987 192 COSMIC
COSN30540081 355 COSMIC
COSN19144106 440 COSMIC
COSN31519758 522 COSMIC
COSN25129819 526 COSMIC
COSN31543834 559 COSMIC
COSN22120467 568 COSMIC
COSN31549780 723 COSMIC
COSN31537649 724 COSMIC
COSN26641098 737 COSMIC
COSN26565736 767 COSMIC
COSN8745698 879 COSMIC
COSN29195512 882 COSMIC
COSN31530502 952 COSMIC
COSN4621326 982 COSMIC
COSN15663092 1084 COSMIC
COSN21588740 1262 COSMIC
COSN15014485 1401 COSMIC
COSN26799488 1467 COSMIC
COSN27975846 1470 COSMIC
COSN8174173 1484 COSMIC
COSN17182128 1563 COSMIC
COSN26772816 1583 COSMIC
COSN22772111 1613 COSMIC
COSN18914420 1989 COSMIC
COSN20889568 2125 COSMIC
COSN28734475 2143 COSMIC
COSN30163118 2322 COSMIC
COSN31485769 2360 COSMIC
COSN9625747 2432 COSMIC
COSN31488749 2449 COSMIC
COSN6274619 2580 COSMIC
COSN31527752 2590 COSMIC
COSN25724146 2664 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1396465999 4 dbSNP
rs1455710929 8 dbSNP
rs756841264 9 dbSNP
rs1399815181 11 dbSNP
rs1408070561 13 dbSNP
rs1178440942 14 dbSNP
rs1477295183 17 dbSNP
rs1246665002 20 dbSNP
rs1425953034 24 dbSNP
rs1194844015 25 dbSNP
rs749239153 28 dbSNP
rs1364178173 30 dbSNP
rs375465265 33 dbSNP
rs200197842 35 dbSNP
rs747869849 37 dbSNP
rs1286360138 41 dbSNP
rs1158681567 42 dbSNP
rs1217567912 42 dbSNP
rs144710695 43 dbSNP
rs558426880 45 dbSNP
rs540032372 48 dbSNP
rs1194414727 49 dbSNP
rs751177817 50 dbSNP
rs779555895 51 dbSNP
rs1308750635 52 dbSNP
rs1360290864 55 dbSNP
rs363849 57 dbSNP
rs891030975 69 dbSNP
rs1012492700 80 dbSNP
rs895406015 82 dbSNP
rs181952614 87 dbSNP
rs1031307366 89 dbSNP
rs1038325459 92 dbSNP
rs942224869 103 dbSNP
rs562749473 107 dbSNP
rs1391683888 114 dbSNP
rs755780314 118 dbSNP
rs111609067 122 dbSNP
rs879588724 126 dbSNP
rs190757129 127 dbSNP
rs1445928733 131 dbSNP
rs1383989446 138 dbSNP
rs1457824719 140 dbSNP
rs767810836 140 dbSNP
rs1374799445 142 dbSNP
rs554631037 147 dbSNP
rs1190451205 152 dbSNP
rs1047830611 156 dbSNP
rs933378359 157 dbSNP
rs1449953745 158 dbSNP
rs1408528695 159 dbSNP
rs1330954442 171 dbSNP
rs1383720132 174 dbSNP
rs1454713823 175 dbSNP
rs1312979969 183 dbSNP
rs923299493 187 dbSNP
rs543028275 192 dbSNP
rs1247221545 195 dbSNP
rs1228100412 199 dbSNP
rs974737007 201 dbSNP
rs572498280 204 dbSNP
rs766125141 204 dbSNP
rs1290125068 208 dbSNP
rs1208791838 216 dbSNP
rs1350995921 218 dbSNP
rs16960899 223 dbSNP
rs752081445 227 dbSNP
rs1428552500 228 dbSNP
rs989782818 242 dbSNP
rs1342022761 245 dbSNP
rs376410505 246 dbSNP
rs1170409242 251 dbSNP
rs1407193739 252 dbSNP
rs539383558 253 dbSNP
rs886051243 254 dbSNP
rs571869753 255 dbSNP
rs970449151 265 dbSNP
rs200718684 266 dbSNP
rs886051242 268 dbSNP
rs1297642124 271 dbSNP
rs748707223 272 dbSNP
rs1283661557 273 dbSNP
rs1047737230 276 dbSNP
rs886051241 286 dbSNP
rs1201421568 291 dbSNP
rs1011876253 300 dbSNP
rs1485919046 302 dbSNP
rs1206319391 307 dbSNP
rs1169259382 310 dbSNP
rs894774727 311 dbSNP
rs1042078 314 dbSNP
rs1006865592 315 dbSNP
rs537505904 317 dbSNP
rs1481593497 318 dbSNP
rs920082241 319 dbSNP
rs537909430 325 dbSNP
rs974310310 330 dbSNP
rs763450242 332 dbSNP
rs773342320 338 dbSNP
rs933429195 341 dbSNP
rs963748087 346 dbSNP
rs1382758303 350 dbSNP
rs1399290379 351 dbSNP
rs1303647407 353 dbSNP
rs901928828 354 dbSNP
rs1347186642 380 dbSNP
rs1375886944 382 dbSNP
rs1478882079 383 dbSNP
rs186005462 386 dbSNP
rs548674669 388 dbSNP
rs943371991 389 dbSNP
rs1258413108 396 dbSNP
rs886051240 406 dbSNP
rs1487651039 412 dbSNP
rs1216546155 413 dbSNP
rs914541392 414 dbSNP
rs989443401 417 dbSNP
rs936579323 418 dbSNP
rs755147629 440 dbSNP
rs1189836146 442 dbSNP
rs986526476 451 dbSNP
rs533522969 454 dbSNP
rs923838873 467 dbSNP
rs1449464923 473 dbSNP
rs1161427862 478 dbSNP
rs955018922 481 dbSNP
rs1419119626 484 dbSNP
rs1164148470 489 dbSNP
rs977898891 492 dbSNP
rs1367302264 497 dbSNP
rs1434119665 498 dbSNP
rs140923867 501 dbSNP
rs761985133 503 dbSNP
rs990506418 520 dbSNP
rs1205214488 525 dbSNP
rs1342136926 526 dbSNP
rs968026887 527 dbSNP
rs1273102563 530 dbSNP
rs959092536 530 dbSNP
rs1022545724 532 dbSNP
rs1221371559 536 dbSNP
rs551258633 537 dbSNP
rs1006505865 546 dbSNP
rs1179195525 552 dbSNP
rs1274582387 552 dbSNP
rs1055858503 561 dbSNP
rs1417677535 563 dbSNP
rs1184285292 566 dbSNP
rs886686959 568 dbSNP
rs1002975429 573 dbSNP
rs1387079263 586 dbSNP
rs1403515772 592 dbSNP
rs1231380978 594 dbSNP
rs1354915116 602 dbSNP
rs1026526739 603 dbSNP
rs1328872126 609 dbSNP
rs1160163024 614 dbSNP
rs1375685503 615 dbSNP
rs997690529 618 dbSNP
rs780110628 634 dbSNP
rs1316504355 638 dbSNP
rs1047093313 643 dbSNP
rs1227138504 646 dbSNP
rs1289733063 647 dbSNP
rs1308460087 648 dbSNP
rs533061153 650 dbSNP
rs1206983665 651 dbSNP
rs1256479090 656 dbSNP
rs368918344 663 dbSNP
rs1409276996 682 dbSNP
rs1457477646 685 dbSNP
rs930220028 689 dbSNP
rs1245014710 693 dbSNP
rs1369941059 706 dbSNP
rs920215896 709 dbSNP
rs901981116 710 dbSNP
rs1430151095 712 dbSNP
rs1168253923 714 dbSNP
rs375866380 722 dbSNP
rs886051239 724 dbSNP
rs397702821 729 dbSNP
rs13598 730 dbSNP
rs1425634729 731 dbSNP
rs1356954010 732 dbSNP
rs1008046275 745 dbSNP
rs1479274847 746 dbSNP
rs893172116 750 dbSNP
rs1363266114 759 dbSNP
rs1413680758 760 dbSNP
rs55717426 764 dbSNP
rs181853264 765 dbSNP
rs1317565226 771 dbSNP
rs113200355 779 dbSNP
rs1248911845 781 dbSNP
rs1440772173 781 dbSNP
rs1209497223 790 dbSNP
rs1212890552 794 dbSNP
rs1443460689 798 dbSNP
rs1042256926 818 dbSNP
rs949238913 827 dbSNP
rs1422693633 828 dbSNP
rs917731291 833 dbSNP
rs771786987 834 dbSNP
rs1422541473 835 dbSNP
rs959375379 842 dbSNP
rs1022238055 845 dbSNP
rs1012181410 846 dbSNP
rs745618973 864 dbSNP
rs774436169 866 dbSNP
rs189749406 867 dbSNP
rs1340308929 876 dbSNP
rs950377853 893 dbSNP
rs1224429727 900 dbSNP
rs1034852153 912 dbSNP
rs1343117181 912 dbSNP
rs1026577551 914 dbSNP
rs1227941365 919 dbSNP
rs1355894492 926 dbSNP
rs997752209 928 dbSNP
rs572464177 931 dbSNP
rs886051238 938 dbSNP
rs1017779961 940 dbSNP
rs749224599 948 dbSNP
rs1244682075 949 dbSNP
rs893214024 951 dbSNP
rs1477480677 957 dbSNP
rs1158685518 959 dbSNP
rs527621676 961 dbSNP
rs56024388 967 dbSNP
rs999275120 968 dbSNP
rs1360438730 971 dbSNP
rs777471927 978 dbSNP
rs1405993891 981 dbSNP
rs898503215 982 dbSNP
rs903168255 984 dbSNP
rs886051237 987 dbSNP
rs1329605773 1002 dbSNP
rs886051236 1007 dbSNP
rs1436063791 1014 dbSNP
rs755618124 1018 dbSNP
rs1390479536 1025 dbSNP
rs1159461905 1031 dbSNP
rs1038566198 1034 dbSNP
rs1472031585 1040 dbSNP
rs1042308621 1046 dbSNP
rs949290458 1048 dbSNP
rs1051237557 1054 dbSNP
rs1211470608 1055 dbSNP
rs933732102 1056 dbSNP
rs917782192 1065 dbSNP
rs545672606 1068 dbSNP
rs578205853 1071 dbSNP
rs184921031 1074 dbSNP
rs1437347311 1075 dbSNP
rs1466970469 1080 dbSNP
rs3803350 1084 dbSNP
rs908961653 1088 dbSNP
rs1466536585 1099 dbSNP
rs1165463772 1100 dbSNP
rs1269104989 1101 dbSNP
rs984525410 1105 dbSNP
rs950450809 1109 dbSNP
rs914908419 1114 dbSNP
rs1444731367 1126 dbSNP
rs1308599155 1141 dbSNP
rs918915683 1150 dbSNP
rs976367422 1152 dbSNP
rs1282312604 1157 dbSNP
rs1292171404 1163 dbSNP
rs966282644 1169 dbSNP
rs959312326 1197 dbSNP
rs574181586 1201 dbSNP
rs1034850475 1202 dbSNP
rs1197499923 1206 dbSNP
rs1008150577 1210 dbSNP
rs569485265 1210 dbSNP
rs372333234 1228 dbSNP
rs1190238210 1233 dbSNP
rs1272384294 1235 dbSNP
rs1367166152 1236 dbSNP
rs1283531632 1237 dbSNP
rs1450284824 1241 dbSNP
rs181099623 1245 dbSNP
rs1320930990 1246 dbSNP
rs1456413075 1249 dbSNP
rs566419089 1252 dbSNP
rs1406956988 1264 dbSNP
rs994678310 1265 dbSNP
rs898458048 1268 dbSNP
rs1405437806 1269 dbSNP
rs1412365777 1270 dbSNP
rs368317202 1271 dbSNP
rs1016898550 1274 dbSNP
rs1318382503 1277 dbSNP
rs1227942798 1279 dbSNP
rs1279822861 1285 dbSNP
rs776894114 1287 dbSNP
rs1217659413 1290 dbSNP
rs1182306517 1297 dbSNP
rs1263314525 1297 dbSNP
rs143446014 1298 dbSNP
rs1249071167 1301 dbSNP
rs1188295111 1310 dbSNP
rs1254760377 1313 dbSNP
rs1442328499 1316 dbSNP
rs569152308 1325 dbSNP
rs796142696 1326 dbSNP
rs934204031 1326 dbSNP
rs1170257298 1328 dbSNP
rs751852028 1334 dbSNP
rs766719764 1341 dbSNP
rs1248659388 1342 dbSNP
rs1222490472 1343 dbSNP
rs896407852 1350 dbSNP
rs1055015933 1351 dbSNP
rs550626793 1353 dbSNP
rs1382737287 1355 dbSNP
rs1299904168 1360 dbSNP
rs1287754850 1365 dbSNP
rs77212138 1368 dbSNP
rs887593257 1370 dbSNP
rs1283600718 1371 dbSNP
rs1049315076 1375 dbSNP
rs1230502335 1379 dbSNP
rs573714136 1383 dbSNP
rs929034319 1392 dbSNP
rs918966645 1394 dbSNP
rs886051235 1396 dbSNP
rs886051234 1398 dbSNP
rs927897236 1399 dbSNP
rs561772776 1409 dbSNP
rs975750262 1410 dbSNP
rs1218018799 1417 dbSNP
rs1265908676 1418 dbSNP
rs1298124501 1424 dbSNP
rs750902806 1432 dbSNP
rs1359510024 1436 dbSNP
rs549498511 1437 dbSNP
rs1268375577 1448 dbSNP
rs1435093814 1463 dbSNP
rs1436685160 1467 dbSNP
rs1348820556 1468 dbSNP
rs1161092328 1469 dbSNP
rs1420321100 1476 dbSNP
rs886051233 1477 dbSNP
rs910820955 1479 dbSNP
rs533502309 1484 dbSNP
rs950556890 1485 dbSNP
rs1399231612 1487 dbSNP
rs1391302549 1493 dbSNP
rs560481043 1500 dbSNP
rs1384749947 1501 dbSNP
rs1300109105 1512 dbSNP
rs1335850551 1518 dbSNP
rs370191313 1519 dbSNP
rs957796495 1526 dbSNP
rs1288872469 1527 dbSNP
rs545437535 1532 dbSNP
rs761904999 1533 dbSNP
rs1216391147 1535 dbSNP
rs1427106213 1536 dbSNP
rs1489641864 1537 dbSNP
rs963155212 1544 dbSNP
rs1266859003 1550 dbSNP
rs557225449 1561 dbSNP
rs78442438 1562 dbSNP
rs1378458397 1566 dbSNP
rs4775760 1575 dbSNP
rs1029839086 1577 dbSNP
rs574169581 1579 dbSNP
rs17352989 1580 dbSNP
rs557820296 1582 dbSNP
rs1292590596 1589 dbSNP
rs894451140 1596 dbSNP
rs1034030045 1598 dbSNP
rs774344373 1610 dbSNP
rs1042956547 1619 dbSNP
rs374297351 1619 dbSNP
rs1313988078 1621 dbSNP
rs1275254764 1629 dbSNP
rs886051232 1635 dbSNP
rs1323882298 1641 dbSNP
rs1002106856 1643 dbSNP
rs893584590 1644 dbSNP
rs552538828 1645 dbSNP
rs887643640 1647 dbSNP
rs1048886533 1650 dbSNP
rs1439113682 1652 dbSNP
rs1182392857 1654 dbSNP
rs929086444 1667 dbSNP
rs1305569038 1671 dbSNP
rs886051231 1672 dbSNP
rs1400623114 1700 dbSNP
rs770825180 1706 dbSNP
rs927633594 1715 dbSNP
rs572619690 1716 dbSNP
rs1448036638 1717 dbSNP
rs557301792 1720 dbSNP
rs539021839 1721 dbSNP
rs35929392 1727 dbSNP
rs886051230 1733 dbSNP
rs1227013004 1743 dbSNP
rs1312417542 1744 dbSNP
rs1318991660 1759 dbSNP
rs929224138 1760 dbSNP
rs568791870 1771 dbSNP
rs919089483 1772 dbSNP
rs189534565 1777 dbSNP
rs936258673 1779 dbSNP
rs962748908 1798 dbSNP
rs772970380 1811 dbSNP
rs977560524 1812 dbSNP
rs1177202541 1822 dbSNP
rs909998204 1825 dbSNP
rs967483418 1826 dbSNP
rs1422456092 1836 dbSNP
rs1024355910 1839 dbSNP
rs1432867759 1841 dbSNP
rs992846436 1842 dbSNP
rs1029618446 1844 dbSNP
rs1446489393 1848 dbSNP
rs1427443158 1849 dbSNP
rs1312760730 1860 dbSNP
rs763023832 1876 dbSNP
rs1034349142 1885 dbSNP
rs1341525144 1894 dbSNP
rs1402172768 1905 dbSNP
rs1276603327 1908 dbSNP
rs370279934 1925 dbSNP
rs1338973842 1930 dbSNP
rs183652996 1932 dbSNP
rs886051229 1943 dbSNP
rs1280858658 1946 dbSNP
rs534577080 1949 dbSNP
rs1027952961 1951 dbSNP
rs535798341 1951 dbSNP
rs12050562 1959 dbSNP
rs897639741 1960 dbSNP
rs1262073186 1971 dbSNP
rs1210537572 1975 dbSNP
rs1054860347 1981 dbSNP
rs56194244 1989 dbSNP
rs573501850 1991 dbSNP
rs187799549 1997 dbSNP
rs1413340123 1998 dbSNP
rs1046521878 2000 dbSNP
rs551933552 2003 dbSNP
rs1361715421 2004 dbSNP
rs533347412 2015 dbSNP
rs1350594832 2020 dbSNP
rs1305621902 2023 dbSNP
rs558488257 2024 dbSNP
rs1404950365 2025 dbSNP
rs1303849606 2026 dbSNP
rs544842106 2037 dbSNP
rs73390272 2040 dbSNP
rs561911965 2044 dbSNP
rs372254135 2045 dbSNP
rs1214241681 2048 dbSNP
rs1041921057 2052 dbSNP
rs573127207 2054 dbSNP
rs1200552683 2059 dbSNP
rs1244562202 2069 dbSNP
rs145666070 2070 dbSNP
rs977182970 2072 dbSNP
rs966976873 2076 dbSNP
rs886051228 2078 dbSNP
rs1021598518 2080 dbSNP
rs1238461028 2089 dbSNP
rs575922741 2091 dbSNP
rs1384710732 2108 dbSNP
rs545618801 2110 dbSNP
rs1258168186 2113 dbSNP
rs886051227 2114 dbSNP
rs992900190 2116 dbSNP
rs1460709183 2119 dbSNP
rs1001947627 2120 dbSNP
rs958817369 2131 dbSNP
rs780440382 2132 dbSNP
rs758726224 2135 dbSNP
rs750951818 2143 dbSNP
rs1024623658 2146 dbSNP
rs116443051 2153 dbSNP
rs1259680491 2154 dbSNP
rs11070641 2158 dbSNP
rs993396406 2164 dbSNP
rs1314069752 2165 dbSNP
rs537569325 2173 dbSNP
rs28399903 2190 dbSNP
rs567001419 2191 dbSNP
rs1322926954 2195 dbSNP
rs1177331871 2197 dbSNP
rs1363716052 2204 dbSNP
rs1046015 2207 dbSNP
rs1473370084 2211 dbSNP
rs1165333603 2219 dbSNP
rs886051226 2221 dbSNP
rs1461142726 2226 dbSNP
rs1388157221 2228 dbSNP
rs1018781679 2240 dbSNP
rs1402552872 2245 dbSNP
rs1156962629 2251 dbSNP
rs886051225 2260 dbSNP
rs1459507799 2261 dbSNP
rs1328164320 2266 dbSNP
rs888912207 2276 dbSNP
rs1050253265 2284 dbSNP
rs1282187068 2288 dbSNP
rs1333812877 2296 dbSNP
rs932734094 2298 dbSNP
rs1008691286 2304 dbSNP
rs566130871 2305 dbSNP
rs922708892 2307 dbSNP
rs1443886401 2315 dbSNP
rs370987013 2318 dbSNP
rs1250491962 2324 dbSNP
rs550343613 2325 dbSNP
rs1443477834 2327 dbSNP
rs1190163826 2338 dbSNP
rs1255886761 2340 dbSNP
rs999876424 2345 dbSNP
rs1190244413 2346 dbSNP
rs757291205 2348 dbSNP
rs1041973307 2350 dbSNP
rs1167372466 2352 dbSNP
rs144404153 2360 dbSNP
rs1397733232 2361 dbSNP
rs553177635 2365 dbSNP
rs1265462296 2366 dbSNP
rs989697756 2384 dbSNP
rs754018668 2385 dbSNP
rs1400370495 2387 dbSNP
rs184719603 2395 dbSNP
rs377530465 2398 dbSNP
rs1256098768 2401 dbSNP
rs1346456636 2404 dbSNP
rs1436264975 2419 dbSNP
rs886051224 2421 dbSNP
rs970488736 2430 dbSNP
rs551896957 2432 dbSNP
rs984589763 2436 dbSNP
rs1388682938 2440 dbSNP
rs886051223 2443 dbSNP
rs897442902 2447 dbSNP
rs1391573255 2449 dbSNP
rs533312404 2450 dbSNP
rs1302593393 2453 dbSNP
rs1467600797 2454 dbSNP
rs1170811862 2475 dbSNP
rs1374770321 2484 dbSNP
rs764066567 2486 dbSNP
rs1006084883 2490 dbSNP
rs569190265 2492 dbSNP
rs1299787127 2494 dbSNP
rs918578727 2494 dbSNP
rs1423992956 2495 dbSNP
rs1381333161 2508 dbSNP
rs1383288492 2514 dbSNP
rs75372203 2524 dbSNP
rs1449848700 2532 dbSNP
rs886051222 2533 dbSNP
rs1372229158 2537 dbSNP
rs1050206878 2538 dbSNP
rs961952413 2540 dbSNP
rs933127926 2542 dbSNP
rs1452931322 2545 dbSNP
rs901697000 2547 dbSNP
rs886051221 2556 dbSNP
rs1217866751 2557 dbSNP
rs1288628722 2562 dbSNP
rs529563402 2565 dbSNP
rs945489432 2567 dbSNP
rs573661935 2568 dbSNP
rs1204792264 2576 dbSNP
rs1268307633 2577 dbSNP
rs761025257 2578 dbSNP
rs913884128 2581 dbSNP
rs562022682 2582 dbSNP
rs987329080 2589 dbSNP
rs752936528 2592 dbSNP
rs886051220 2594 dbSNP
rs766307544 2595 dbSNP
rs193104707 2604 dbSNP
rs953304882 2606 dbSNP
rs1339157065 2608 dbSNP
rs936889900 2611 dbSNP
rs1293812383 2622 dbSNP
rs1392424768 2624 dbSNP
rs1384607763 2628 dbSNP
rs886051219 2638 dbSNP
rs762784470 2645 dbSNP
rs1268738664 2647 dbSNP
rs528649124 2650 dbSNP
rs1235747346 2658 dbSNP
rs1331877242 2660 dbSNP
rs926889846 2662 dbSNP
rs981032123 2669 dbSNP
rs371534201 2672 dbSNP
rs1238779822 2673 dbSNP
rs142196699 2674 dbSNP
rs1212006783 2678 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Article - Uchida Y; Chiyomaru T; Enokida H; Kawakami et al.
- Urologic oncology, 2013
OBJECTIVE: We previously demonstrated that miR-133a is a tumor-suppressive microRNA (miRNA) and is commonly down-regulated in human bladder cancer (BC). The aim of this study is to determine a novel oncogenic gene targeted by miR-133a in BC. METHODS: To identify genes targeted by miR-133a, an oligo-microarray analysis was performed using the miR-133a-transfected BC cell lines. For gain/loss-of-function studies, miR-133a/si-glutathione S-transferase pi1 (GSTP1)-transfectants were subjected to XTT assay and flow cytometry to evaluate their cell viability and apoptosis status. The luciferase reporter assay was used to confirm the actual binding sites between miR-133a and GSTP1 mRNA. The mRNA and protein expression of GSTP1 in BC cell lines and clinical samples were evaluated by real-time RT-PCR and Western blot, respectively. RESULTS: MiR-133a transfection induced cell viability inhibition and apoptosis in BC cell lines. We focused on the GSTP1 gene that was the top 7 down-regulated one in the gene profile from the miR-133a-transfectants. MiR-133a transfection repressed expression levels of mRNA and protein levels of GSTP1. A luciferase reporter assay suggested that the actual binding may occur between miR-133a and GSTP1 mRNA. Cell viability inhibition and apoptosis were induced in the si-GSTP1 transfectants compared with the controls (P < 0.005). GSTP1 mRNA expression levels in 43 clinical BCs were significantly higher than those in eight normal bladder epitheliums (P = 0.0277). CONCLUSION: Our data suggest that tumor suppressive miR-133a directly regulated oncogenic GSTP1 gene in BC, and that an anti-apoptotic effect mediated by GSTP1 is maintained by miR-133a down-regulation in human BC.
LinkOut: [PMID: 21396852]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LIHC 0.515 0 0.480 0 49 Click to see details
STAD 0.606 0 0.606 0 32 Click to see details
KIRP 0.58 0 0.471 0 30 Click to see details
KIRC 0.374 0 0.235 0.03 67 Click to see details
BRCA 0.338 0 0.407 0 77 Click to see details
ESCA 0.772 0 0.673 0.01 11 Click to see details
THCA 0.31 0.01 0.353 0 59 Click to see details
HNSC 0.276 0.04 0.203 0.1 42 Click to see details
COAD 0.648 0.04 0.619 0.05 8 Click to see details
KICH 0.348 0.05 0.323 0.06 24 Click to see details
PRAD 0.217 0.07 0.160 0.13 50 Click to see details
BLCA 0.331 0.09 0.300 0.11 18 Click to see details
PAAD -0.749 0.13 -0.400 0.3 4 Click to see details
CESC 0.895 0.15 1.000 0.5 3 Click to see details
UCEC -0.195 0.21 -0.156 0.26 19 Click to see details
LUAD -0.235 0.23 -0.119 0.36 12 Click to see details
LUSC -0.112 0.25 -0.112 0.25 38 Click to see details
CHOL 0.214 0.29 0.350 0.18 9 Click to see details
PCPG 0.136 0.46 0.500 0.33 3 Click to see details
PCPG 0.136 0.46 0.500 0.33 3 Click to see details
PCPG 0.136 0.46 0.500 0.33 3 Click to see details
122 hsa-miR-133a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000325 RHOA ras homolog family member A 1 2
MIRT000327 CDC42 cell division cycle 42 4 2
MIRT000328 ERG ERG, ETS transcription factor 1 1
MIRT000329 HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2 1
MIRT000330 UCP2 uncoupling protein 2 2 2
MIRT000331 KRT7 keratin 7 2 2
MIRT001203 CACNA1C calcium voltage-gated channel subunit alpha1 C 3 1
MIRT001204 HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 4 2
MIRT001816 PKM pyruvate kinase, muscle 1 1
MIRT001986 CASP9 caspase 9 3 3
MIRT002925 KCNQ1 potassium voltage-gated channel subfamily Q member 1 4 1
MIRT003542 FSCN1 fascin actin-bundling protein 1 5 4
MIRT004831 KCNH2 potassium voltage-gated channel subfamily H member 2 4 1
MIRT005604 TAGLN2 transgelin 2 5 4
MIRT005813 LASP1 LIM and SH3 protein 1 3 2
MIRT006571 PNP purine nucleoside phosphorylase 4 2
MIRT006680 MSN moesin 2 1
MIRT007032 EGFR epidermal growth factor receptor 3 5
MIRT007088 VKORC1 vitamin K epoxide reductase complex subunit 1 1 1
MIRT007383 PRDM16 PR/SET domain 16 1 2
MIRT021693 TPM1 tropomyosin 1 1 1
MIRT021695 FBN1 fibrillin 1 1 1
MIRT021696 FAM120C family with sequence similarity 120C 1 1
MIRT021697 BCAN brevican 1 1
MIRT021698 TCTEX1D2 Tctex1 domain containing 2 1 1
MIRT021699 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 1 1
MIRT021700 RFT1 RFT1 homolog 1 1
MIRT021701 SENP1 SUMO1/sentrin specific peptidase 1 1 1
MIRT021702 SMIM14 small integral membrane protein 14 1 1
MIRT021703 PRELID1 PRELI domain containing 1 1 1
MIRT021704 CNN2 calponin 2 3 3
MIRT021705 ARPC5 actin related protein 2/3 complex subunit 5 4 2
MIRT021706 FTL ferritin light chain 2 2
MIRT021707 CERS2 ceramide synthase 2 1 1
MIRT021708 SEC61B Sec61 translocon beta subunit 1 1
MIRT021709 PLEKHA3 pleckstrin homology domain containing A3 1 1
MIRT021710 EGFL7 EGF like domain multiple 7 1 1
MIRT021711 VEGFA vascular endothelial growth factor A 1 1
MIRT021712 PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 1 1
MIRT021713 RGS3 regulator of G protein signaling 3 1 1
MIRT021714 COL1A1 collagen type I alpha 1 chain 4 1
MIRT021715 GSTP1 glutathione S-transferase pi 1 2 1
MIRT035537 SP1 Sp1 transcription factor 2 2
MIRT035579 KLF15 Kruppel like factor 15 1 1
MIRT045837 NR4A2 nuclear receptor subfamily 4 group A member 2 1 1
MIRT052647 BCL2L1 BCL2 like 1 4 2
MIRT052648 MCL1 MCL1, BCL2 family apoptosis regulator 4 2
MIRT053333 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 4 1
MIRT054310 IGF1R insulin like growth factor 1 receptor 3 2
MIRT055599 FAM160B1 family with sequence similarity 160 member B1 2 2
MIRT081957 UBA2 ubiquitin like modifier activating enzyme 2 4 1
MIRT437400 MMP14 matrix metallopeptidase 14 3 1
MIRT437953 ANXA2 annexin A2 4 1
MIRT437954 SNX30 sorting nexin family member 30 4 1
MIRT437955 SGMS2 sphingomyelin synthase 2 4 1
MIRT438719 PDLIM5 PDZ and LIM domain 5 3 1
MIRT452802 PACS2 phosphofurin acidic cluster sorting protein 2 2 2
MIRT462823 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT468494 SESN2 sestrin 2 2 2
MIRT477714 EFHD2 EF-hand domain family member D2 2 2
MIRT483852 EMID1 EMI domain containing 1 2 2
MIRT490039 PRRT2 proline rich transmembrane protein 2 2 2
MIRT491349 CDKN1A cyclin dependent kinase inhibitor 1A 2 4
MIRT504443 MC2R melanocortin 2 receptor 2 2
MIRT505701 SESN3 sestrin 3 2 2
MIRT513521 RHOQ ras homolog family member Q 2 4
MIRT517423 HIST2H2AC histone cluster 2 H2A family member c 2 2
MIRT526599 DCAKD dephospho-CoA kinase domain containing 2 2
MIRT528904 THBS2 thrombospondin 2 2 2
MIRT533060 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT534126 SNX33 sorting nexin 33 2 2
MIRT534700 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 4
MIRT535732 MYPN myopalladin 2 2
MIRT538529 CHMP3 charged multivesicular body protein 3 2 4
MIRT550878 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT551260 PSMG1 proteasome assembly chaperone 1 2 2
MIRT551981 UGT2B10 UDP glucuronosyltransferase family 2 member B10 2 2
MIRT553866 SYAP1 synapse associated protein 1 2 2
MIRT558810 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 2
MIRT559367 ATP13A3 ATPase 13A3 2 2
MIRT560941 ZFP28 ZFP28 zinc finger protein 2 2
MIRT565461 SUPT16H SPT16 homolog, facilitates chromatin remodeling subunit 2 2
MIRT566234 PTMA prothymosin, alpha 2 2
MIRT568217 C11orf24 chromosome 11 open reading frame 24 2 2
MIRT608912 NCDN neurochondrin 2 6
MIRT613229 CCDC39 coiled-coil domain containing 39 2 2
MIRT623563 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT637224 TMEM59 transmembrane protein 59 2 2
MIRT641669 CCNI cyclin I 2 2
MIRT644440 ALDOC aldolase, fructose-bisphosphate C 2 2
MIRT644755 TXNRD3NB thioredoxin reductase 3 neighbor 2 2
MIRT646711 PDE1A phosphodiesterase 1A 2 2
MIRT647577 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT647760 RNF168 ring finger protein 168 2 2
MIRT649267 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT651238 ZMAT4 zinc finger matrin-type 4 2 2
MIRT652146 TRIM71 tripartite motif containing 71 2 2
MIRT657168 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT668302 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT687546 MLEC malectin 2 2
MIRT690857 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT697060 PSMC4 proteasome 26S subunit, ATPase 4 2 2
MIRT699725 SERPINH1 serpin family H member 1 2 2
MIRT700858 PER2 period circadian clock 2 2 2
MIRT705068 C4orf29 abhydrolase domain containing 18 2 2
MIRT709496 ANGPT4 angiopoietin 4 2 2
MIRT713925 PIGR polymeric immunoglobulin receptor 2 2
MIRT716058 SFTPB surfactant protein B 2 2
MIRT716724 APOL6 apolipoprotein L6 2 2
MIRT721677 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT723379 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT731340 IGF1 insulin like growth factor 1 1 1
MIRT731591 ZEB1 zinc finger E-box binding homeobox 1 1 1
MIRT732526 PTBP1 polypyrimidine tract binding protein 1 2 0
MIRT732527 KDM5C lysine demethylase 5C 2 0
MIRT732589 BCL2 BCL2, apoptosis regulator 2 0
MIRT732590 CASP3 caspase 3 2 0
MIRT733594 PPP2CA protein phosphatase 2 catalytic subunit alpha 3 0
MIRT735355 MB myoglobin 1 0
MIRT735744 CDCA8 cell division cycle associated 8 3 0
MIRT736984 SET SET nuclear proto-oncogene 1 0
MIRT737550 TGFB1 transforming growth factor beta 1 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-133a Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-133a Proanthocyanin NULL 108065 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-133a Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-133a Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-133a Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miR-133a Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miR-133a Benzene NULL 241 MiRNA PCR array white blood cell 24780745 2014 down-regulated
miR-133a Benzene NULL 241 MiRNA PCR array blood mononuclear cells 24780745 2014 down-regulated
miR-133a Ibandronate approved 60852 Quantitative real-time PCR Periodontal ligament stem cells (PDLSCs) 21108928 2011 down-regulated
miR-133a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-133a Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-133a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 down-regulated
miR-133a Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-133a Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-133a 5-Fluorouracil approved 3385 Quantitative real-time PCR colon cancer cells 17702597 2007 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H358, H1993)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H1155, H358, H1993)
hsa-miR-133a-3p Sunitinib 5329102 NSC750690 approved resistant High Metastatic Renal Cell Carcinoma tissue and cell line (Caki-2)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant Low Esophageal Squamous Cell Carcinoma tissue
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Head And Neck Squamous Cell Carcinoma cell line (Hep-2, NP69)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer tissue
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Urothelial Bladder Cancer cell line (T24)
hsa-miR-133a-3p Gemcitabine 60750 NSC613327 approved sensitive Low Urothelial Bladder Cancer cell line (T24)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant Low Prostate Cancer cell line (PC-3-R)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved sensitive Low Nasopharyngeal Cancer cell line (HONE1, SUNE1)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer cell line (MGC-803)
hsa-miR-133a-3p Bromocriptine 31101 NSC169774 approved resistant Low Prolactinoma tissue
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-133a-3p Gefitinib 123631 NSC715055 approved sensitive Low Non-Small Cell Lung Cancer cell line (PC-9)
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Etoposide 36462 NSC141540 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Vinorelbine 44424639 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Vincristine 5978 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (SKOV3, A2780)
hsa-miR-133a-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-133a-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-133a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-133a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-133a-3p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-133a-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-133a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-133a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine sensitive cell line (Bats-72)

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