miRTarBase - #MIRT021696


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pre-miRNA Information
pre-miRNA hsa-mir-133a-1   
Genomic Coordinates chr18: 21825698 - 21825785
Synonyms MIRN133A1, MIR133A1
Description Homo sapiens miR-133a-1 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-133a-2   
Genomic Coordinates chr20: 62564912 - 62565013
Synonyms MIRN133A2, MIR133A2
Description Homo sapiens miR-133a-2 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-133a-3p
Sequence 53| UUUGGUCCCCUUCAACCAGCUG |74
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30104664 8 COSMIC
COSN30455205 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369575411 9 dbSNP
rs746815210 11 dbSNP
rs1382873526 13 dbSNP
rs553267926 15 dbSNP
rs1172821195 16 dbSNP
rs182673735 19 dbSNP
rs781929120 20 dbSNP
rs1296628341 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma .
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Muscle Reverse transcription-polymerase chain reaction
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma Real-time reverse transcription PCR
B2TV7U miR-133a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Serum Real-time polymerase chain reaction
Gene Information
Gene Symbol FAM120C   
Synonyms CXorf17, ORF34
Description family with sequence similarity 120C
Transcript NM_017848   
Other Transcripts NM_198456   
Expression
Putative miRNA Targets on FAM120C
3'UTR of FAM120C
(miRNA target sites are highlighted)		 
>FAM120C|NM_017848|3'UTR
   1 TAAGCTGAAGATGGCTTCACCAAACCAGGAAGAGGGAAAAACTTTTACTTTTCTGATTTTAGGCCCAAGCTAGAGGAGGA
  81 TATAAATGCTTACCCTAGATTTCTCCAGGATTTTGGTGGGATGTCCTATTGTGTCCATCTTTTCCCCTTCCCTGCCTGTT
 161 TCTGGGACTTCAGATTCAGTGGTCTGTTTCTGGAGAAGTTCTGGTCAAAGATGAATGGCAGTAAGACTAGGTCCTAGTCT
 241 CAAATTGAAGATATAGCACCAATAGTTTATTTATCTCCTCTGGGAGCCTAGTAAGGCAGTAGCTGTCAGAAATTGGGTAT
 321 CATCACATAAGGTCCTATAGAAAAGCTCTAGCTTTGGTTTTTCTGAGCATTTATAATGATACTCATTATCAAAGACTTAT
 401 ATGATAAACCTATGAGGTTGTGGGGACAGCTGTGGCCTCCTGAGGTTTTTTTTTGTTTTTTTTTTTTCTCTATGAAGTGG
 481 TATCTACCTCTTCTTCACTCCTTCCAACTTACCTACCCCTGGATTTTGTACCACCACCTCTAGCTTTGGCCTGACAATCA
 561 GATAGGTAGATGTTTTCAGAAAAGTAAGGTAGTATTGGTTATTTTAATTTTTATTTTTTATTTTATACACTTCAAAAAAA
 641 CTATCAATGGCCTTTGTACTGGGGGATTCAAGTGAATCAGAAAAGTACTGGGCAGATTTTTCCTGCCTCTCAACCAGTGC
 721 ATTGTTTGTAAAATAGAAGATGTGGCACAGTTCATTCACTCCCTATTGCCCACACCATGAAAGGGTGGGAATCAGTGTAA
 801 TGAACTTGAGTACGAAAGGGACTCAAGAGACTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAATGTGT
 881 GCTTGTGTGTGGGTGTGGGTGGATGTTGTGTGGGTGGGTGTATATATGAATGTGTGTATATGCATACACATACCCTTTAT
 961 ATAAAGAGACAGATCTATTTATCTATACATATTTTATATATATGTAAGTGTGTGTGTATGTGTGTATATATGTGTGTATA
1041 TATATATACACACATATATACACACATACATACATACATACATACATACATACATACATGGTGATGTCCCAGAGGATTTA
1121 CTCAATTTCCCAGAAATGCTTCCACTGCTATGGAGTGGAAGGTTTCAAAAGACCACACTTTTAATCTGAAATTCTTACTA
1201 AGTCACAGTGCATTCACAACTATGAGAAGTTGGATGGGCTTCTCTAAATCAGACAAAAAGTACTTTCCAGAAATTGCCTG
1281 TTCAGAACAATAAACTCTTGGGTTGTTACAAGCTTAATCTTGAACAGAGCCCTCACATCCCATATGGTGAAAACAGGAGG
1361 TTGGAATGGGATTGGGAAGAGTTGGGCATTTCCTTATGAAGGTTTGGAGAGAAAAGGGGGGATGGGAGGTGACTACCATT
1441 TGAAAGGGCTTTCAGCCAATTTGGAGGAAATCTCTTCTGGAACTCCAGGGTCAAATTGGTTTCAGGCTAGAATTGATTGA
1521 CATGAATCCCTGAAGGAGAGAGGACTAGCTTTGGAAAGATAGGGTAGGGAAGTGTGAGGAAACTATTTGATTTTACACGC
1601 CTAGATTGTTTCATTTGTTCATTGACATTCTGACTACTGGATCTTTTCATTTGCTTTGCAAGGAAGACTTTAGAGGACTC
1681 TGGCCTGGGCCTTGAGAAGAATTCTATTAAAAGATTCTCAGCCTCCTGTGTGGCCAGGATCTGCCCAGGATAAAGAGGCT
1761 ATTCCTCCTTGCTGGAGATAATCTTGAGACAACCTTGCATTTCCAGTTTCCCTCCTTGGGCAGCCTAACTATGAGGGAGG
1841 GAAACATGGCTTGCAATAAATTAGCATTGTGTCTTCATTCAGGAATTGAGGCTTCCAGCCTCATATACCTCCTTTTGGGC
1921 TTTGTGATATTCTTGCCCAAGAAGTACCATTTCTACAGAAATACAACTGACTAATCTTCTAGCAGGGTTCTTTTTGAAAA
2001 ACCCCATGCACCTTAACCCACAGCAGGTCCTTGGTGATTTTTGCCCAGACAACCAGAAGGCTATTTGCTTACTGCCCACT
2081 TACAATGACCAGATCATAGGAAATTGAAAACAGTGTCAGACTATTTAGTCCTAATCTGTCCCAGATTAAGAGAATCCATG
2161 ATTTTCAGGGGGAGGGAGCCCTGCAATGCCTTGACCCCTGCCCAGATACTTCTTACATAAACCAAAGAAAAATGACAAGA
2241 GTGTACATCTAACCAGACAGAAGTAGAAACAAAGTATAGAAAAACCTCCTCTTTGGAATCAGCTCCCTTAATGTGGTCCC
2321 CCTTCTCTTGGACCTGCCCAACCTTTCACAACGTCTTGAAGGTAGGACTTCTATATCCAGCAAAGGAAGGGATAGTAGTA
2401 AATTTACATGGCTTGGAATTTTCTTTCTGGAGCCACAGAGGGATGAATCCTTTGGAGCTCTAAAAGCAACCAGTATCACT
2481 GAGCTGTGAGATACCTATATCTCCATTTTCTAATAGGAAGCACTTGGACTTAAAATTGCTAAGATATTTTTTGCAGTTGC
2561 TATTTCTGTGCATCTTGAATCTATCTGACACAATCAAATGACAGTATTGTTAACTCTCACACCATTAAGAAAATTTCTTA
2641 TTTTGTAGGCATTCACTGTGAGAGGTAAAATTGCTGCTTTGGCAGGTATGATTCCAGTTTGCCAAACGGCTTTTCTTCCT
2721 TCCACAACCTCTTTTTCCCCTAGCCCAGGGTGAAACAAGTGGGTCATCTCCAACCTTGATTTTTATTTGGATTCAGCATT
2801 TTGGGTTTGGAAGGTTACAAGAAGGAACCATAAATGGCCATATTCCTAGATTTTTATTTATCTGACAAAATACACAACTT
2881 AAAAGCCAGGAAAACTAAGGTTCATTACAGGGAGATGAACTTTTTCTAATTGGAGGACAAATTGTGGAAGGTGGGGTCTG
2961 ATCTTTGCTTCACCACTTGAAGAGACTGTCATCCTTCACCTGAGGTTCCATTTCTAGCTTTTATGTGACCTCTCTTGAAC
3041 AAAGTCATTTGGGAACCCCCAGAAATGACCCCTTTACATTGTAGGACCATAAGCAAAACACTGGTTGTGTATAGTCACTG
3121 ATCCCCAAGGACTTGCAGTTTTTTATTTCTGCTGGTGTGTCTTGGGATCAGCTTATAACTCCTACTCTTACTTAGTCAGT
3201 GACCAGTCCAGTCTGGTCTGGACCAGGCCTGACAAACTTCTGCTCACTTGCATCATTTTCATTCTGAGCCAGTAGGACTT
3281 TGGGTAGACTTTAAAGCCCAAGAATTGGTACTCGCTTTGGCTAGTGACATTTGATTTTTGTCTCCATCTTGATTTCTGAC
3361 ATCATTGGCCAAGTCACATTAACTTTTTTTGATCACTGAGAAAAACAGTCGAACAAGGCATTACAGAGGGTGGTTAAGGT
3441 AGAGGGTGGGGGGCAGGAATGCTTATGTAGGATAGAAAGAATGTGGGGGTAGCTGTTTGGTTATGGTGATCCAGTCCTTT
3521 GGAACCTTACAAGGCTCCTGTGGGCATGTCAATGTTACCATTACAGCCTCTACGACCCACCCACCTTTGAAAAGTCAGTA
3601 CAAGTAGACCACAGTTTAAAGTAGTTAGTATAATTCTACTAAGGTTTAATCATTATACTTGTTCACTTCCTGGTGCATAT
3681 TTCCTAAATATGCTTGGGGTGTGGGGTGGGGGGTTGAGTTTTCACTGTTCCATTGCGTGTCATCTTATATTTTTCTCCAT
3761 CCTGTGACTTTGGCATCTTACTCGACTTTCTATTTTCTTTTCCCTTGGCTTATTGCAGTAGTCTGCTGGTGCAGGTAGAG
3841 AGCTCAGTGCACCTATTCCCCTGTTACTGCTAATTATCTTGAATATTGTCAGAGGTTATTTTGATGTTCTAAGAATATAA
3921 AGTCATTTTTTACAAAATCATCTTTTCCAAGTTAAAAGCAAAATAAAAAAATCCCCTGTGCTAGGGTGCCCATTTCAGCT
4001 TTTGACATTGCCCCTGTACTTTTATAGATGCTCTTTTTGTCCGTGTTGGTAGTAACTAATGACTAGTGAATTTTCATGTA
4081 AATGAAGCAAAATAAATATTTCAGATTTTATTAATCTCTCATAACCCAGCCAAATCTGATGACTTCATTTTAATTGCTTC
4161 CCAGAAAGCACTTCCCCTCCTACCTTCTATTCTATTCTATTCTATTCTATTCTATTCTATTCTATTCTATTCTATTCTAT
4241 TCTGTTCTATTCTGTTCTATTCTGTTTTTAGAATAACACACTAGGTAAAGAAACTTTAACTGCAAGGAGTCAGTGACTTT
4321 TAGTGCTCCCTGATAAATGATGTTATTGACAAAAGTAAAAAATTATTTCATTGTTTTTTTCCTGTATTACTATCTCCTCT
4401 CCTGTGCTTTTGACAGTGTGTTTAGTGGATGGATAATATGTATTTCTCTTTCCCACTCCCAGATTCCAAATTCCCTGCCT
4481 TTTTGGCCCACCTCACCACAAAAGCTCCATAGTTTATTAATGTAAGTTTGAATGGATGCTTCTTTGGGGAAACTTCAGGA
4561 GTTAATGGAAGAGTTTCAGAAAGGAATGAGAATGCCTCAGGAGTTGTTCTGTGATGGAAATTGGTCTGTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gucGACCA-ACUUCCCCUGGUUu 5'
             ||||| |     ||||||: 
Target 5' agtCTGGTCT-----GGACCAGg 3'
 3210 - 3227 130.00 -15.70
2 
miRNA  3' guCGACCA-AC-UUCCCCUGGUUu 5'
            |||||| ||    ||||:||: 
Target 5' ctGCTGGTGTGTCTTGGGATCAGc 3'
 3149 - 3172 128.00 -19.40
3 
miRNA  3' gucgaccAACUUCCCCUGGUuu 5'
                 ||| |  ||||||  
Target 5' ctttacaTTGTA--GGACCAta 3'
 3072 - 3091 127.00 -8.60
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1183641378 37 dbSNP
rs782313813 39 dbSNP
rs1414686512 42 dbSNP
rs1428389039 47 dbSNP
rs1167297392 57 dbSNP
rs1372736779 78 dbSNP
rs1430792779 83 dbSNP
rs1312724022 94 dbSNP
rs1357041783 97 dbSNP
rs944438502 103 dbSNP
rs1284228589 107 dbSNP
rs1360702588 121 dbSNP
rs1225992700 137 dbSNP
rs911585730 144 dbSNP
rs1052754233 152 dbSNP
rs1299745967 161 dbSNP
rs1342849320 188 dbSNP
rs934577345 194 dbSNP
rs1276291593 221 dbSNP
rs1440887021 227 dbSNP
rs925871088 254 dbSNP
rs1238083561 256 dbSNP
rs1464512315 263 dbSNP
rs782310536 299 dbSNP
rs1392564458 305 dbSNP
rs969908455 307 dbSNP
rs915729089 308 dbSNP
rs1173382115 316 dbSNP
rs990943594 317 dbSNP
rs782103911 322 dbSNP
rs1415786317 326 dbSNP
rs1334411259 338 dbSNP
rs1344030613 365 dbSNP
rs960815173 369 dbSNP
rs1322047663 374 dbSNP
rs1365796373 378 dbSNP
rs1035438387 394 dbSNP
rs1233536098 396 dbSNP
rs1004844856 400 dbSNP
rs951051985 409 dbSNP
rs1221088408 420 dbSNP
rs1279585871 425 dbSNP
rs1027834432 434 dbSNP
rs1206870921 435 dbSNP
rs995034541 438 dbSNP
rs1250035592 446 dbSNP
rs369193732 455 dbSNP
rs781954563 455 dbSNP
rs782397730 455 dbSNP
rs1173583546 456 dbSNP
rs782328681 457 dbSNP
rs1039174007 458 dbSNP
rs1388758068 458 dbSNP
rs1008633417 461 dbSNP
rs1321511810 462 dbSNP
rs1332820134 463 dbSNP
rs1436927043 464 dbSNP
rs1278782365 467 dbSNP
rs1226524866 468 dbSNP
rs1328728078 468 dbSNP
rs369853014 468 dbSNP
rs782037554 468 dbSNP
rs1329943273 469 dbSNP
rs1209709967 472 dbSNP
rs1288329172 483 dbSNP
rs1453899177 496 dbSNP
rs1199985686 497 dbSNP
rs1251605222 500 dbSNP
rs782204917 512 dbSNP
rs890174010 525 dbSNP
rs1053217749 528 dbSNP
rs1471376994 536 dbSNP
rs1183935501 544 dbSNP
rs1411971052 598 dbSNP
rs782407337 606 dbSNP
rs1456980110 607 dbSNP
rs1161020318 610 dbSNP
rs934318257 612 dbSNP
rs1405935695 615 dbSNP
rs1307128478 630 dbSNP
rs782199618 641 dbSNP
rs1348437898 643 dbSNP
rs1408163871 647 dbSNP
rs1290463541 655 dbSNP
rs782178319 662 dbSNP
rs1244149898 679 dbSNP
rs1043019076 704 dbSNP
rs1263796131 721 dbSNP
rs1359047663 724 dbSNP
rs1210981330 725 dbSNP
rs1274315534 775 dbSNP
rs1482281081 803 dbSNP
rs782565587 813 dbSNP
rs1252085004 814 dbSNP
rs1422921144 826 dbSNP
rs1184754891 827 dbSNP
rs868995644 830 dbSNP
rs868972832 831 dbSNP
rs1368411338 833 dbSNP
rs1473064221 833 dbSNP
rs1431390307 845 dbSNP
rs782477180 851 dbSNP
rs1308477010 853 dbSNP
rs1397437088 867 dbSNP
rs1395715619 872 dbSNP
rs1198405756 874 dbSNP
rs1231034055 874 dbSNP
rs1246081139 874 dbSNP
rs1257580957 874 dbSNP
rs1275859893 874 dbSNP
rs1297528282 874 dbSNP
rs1310600152 874 dbSNP
rs1340736347 874 dbSNP
rs1342373894 874 dbSNP
rs1442512185 874 dbSNP
rs1482697554 874 dbSNP
rs60802365 874 dbSNP
rs782063882 874 dbSNP
rs782204784 874 dbSNP
rs1491333318 875 dbSNP
rs782637779 875 dbSNP
rs1491179377 876 dbSNP
rs1257387626 880 dbSNP
rs1207513222 882 dbSNP
rs1345367620 882 dbSNP
rs782505230 882 dbSNP
rs781901160 883 dbSNP
rs1466158637 886 dbSNP
rs782722597 886 dbSNP
rs1189175056 892 dbSNP
rs1266324657 892 dbSNP
rs1431240649 913 dbSNP
rs1178037084 918 dbSNP
rs1379584383 922 dbSNP
rs1470453951 933 dbSNP
rs1158459757 951 dbSNP
rs948615969 959 dbSNP
rs1437822015 966 dbSNP
rs1289983628 972 dbSNP
rs1367592544 972 dbSNP
rs1385454158 974 dbSNP
rs1303920798 975 dbSNP
rs915782786 975 dbSNP
rs782523667 987 dbSNP
rs1227421219 1003 dbSNP
rs1265648278 1010 dbSNP
rs1209214547 1012 dbSNP
rs1330606340 1012 dbSNP
rs782286355 1014 dbSNP
rs1192685699 1018 dbSNP
rs1487503502 1018 dbSNP
rs781847884 1020 dbSNP
rs1480864250 1022 dbSNP
rs1181737987 1032 dbSNP
rs1409779972 1032 dbSNP
rs928046039 1037 dbSNP
rs782479836 1038 dbSNP
rs950776242 1043 dbSNP
rs1027591046 1047 dbSNP
rs1295602160 1049 dbSNP
rs1366614035 1055 dbSNP
rs1408767719 1055 dbSNP
rs973663619 1057 dbSNP
rs868924496 1061 dbSNP
rs201493547 1063 dbSNP
rs200850761 1067 dbSNP
rs1223847931 1070 dbSNP
rs1311439722 1071 dbSNP
rs1319805169 1073 dbSNP
rs1223720241 1075 dbSNP
rs1482614562 1081 dbSNP
rs1202835498 1092 dbSNP
rs1249888200 1094 dbSNP
rs1177834728 1100 dbSNP
rs1366518678 1100 dbSNP
rs1367446011 1100 dbSNP
rs1413189353 1100 dbSNP
rs1473720421 1100 dbSNP
rs782128038 1105 dbSNP
rs1429496455 1106 dbSNP
rs1306637053 1111 dbSNP
rs1371988953 1116 dbSNP
rs1442514677 1123 dbSNP
rs1301709588 1125 dbSNP
rs1376350648 1136 dbSNP
rs1229905857 1141 dbSNP
rs1315632646 1152 dbSNP
rs782270918 1162 dbSNP
rs1009045327 1174 dbSNP
rs1341457396 1198 dbSNP
rs781990334 1198 dbSNP
rs1225866138 1208 dbSNP
rs1276575150 1210 dbSNP
rs782638457 1211 dbSNP
rs1439722713 1215 dbSNP
rs1205524630 1221 dbSNP
rs890216965 1234 dbSNP
rs782496765 1237 dbSNP
rs1482324002 1241 dbSNP
rs1185558759 1276 dbSNP
rs1386405387 1280 dbSNP
rs1449433851 1285 dbSNP
rs782804754 1307 dbSNP
rs1031450772 1309 dbSNP
rs1167075030 1309 dbSNP
rs1410118556 1317 dbSNP
rs782523984 1323 dbSNP
rs998993430 1329 dbSNP
rs904228938 1330 dbSNP
rs1357129301 1335 dbSNP
rs1449581895 1338 dbSNP
rs1336867485 1357 dbSNP
rs1364347251 1371 dbSNP
rs1042738090 1375 dbSNP
rs1432845333 1383 dbSNP
rs781798609 1401 dbSNP
rs1299491431 1404 dbSNP
rs1215323220 1416 dbSNP
rs1278166783 1417 dbSNP
rs948626943 1421 dbSNP
rs1464810006 1422 dbSNP
rs34782811 1422 dbSNP
rs1187233728 1428 dbSNP
rs1244136963 1437 dbSNP
rs782148650 1470 dbSNP
rs1172425226 1488 dbSNP
rs894357279 1492 dbSNP
rs1415866321 1519 dbSNP
rs45552536 1546 dbSNP
rs938500337 1563 dbSNP
rs1455517617 1564 dbSNP
rs1322486314 1567 dbSNP
rs1327015656 1584 dbSNP
rs782312394 1585 dbSNP
rs1272900724 1587 dbSNP
rs782231626 1588 dbSNP
rs983576378 1598 dbSNP
rs781944626 1599 dbSNP
rs782489727 1606 dbSNP
rs1286948435 1612 dbSNP
rs782724529 1613 dbSNP
rs1448119069 1634 dbSNP
rs1198566791 1639 dbSNP
rs1245361575 1640 dbSNP
rs1481188063 1642 dbSNP
rs1199709395 1643 dbSNP
rs1410512339 1651 dbSNP
rs189038554 1653 dbSNP
rs1471318260 1661 dbSNP
rs1159863882 1683 dbSNP
rs920628077 1694 dbSNP
rs1385543445 1703 dbSNP
rs1404744608 1706 dbSNP
rs1321283986 1714 dbSNP
rs781825513 1743 dbSNP
rs1406932236 1747 dbSNP
rs1284146312 1749 dbSNP
rs782236325 1758 dbSNP
rs1350171999 1761 dbSNP
rs1226613877 1774 dbSNP
rs1281393338 1793 dbSNP
rs964951325 1794 dbSNP
rs1351962016 1810 dbSNP
rs1209798578 1831 dbSNP
rs186126946 1832 dbSNP
rs1017785727 1835 dbSNP
rs1490947916 1840 dbSNP
rs371017503 1846 dbSNP
rs1223768472 1847 dbSNP
rs782778131 1864 dbSNP
rs782114740 1865 dbSNP
rs1183325712 1881 dbSNP
rs1363901832 1893 dbSNP
rs1472403431 1896 dbSNP
rs1161404246 1906 dbSNP
rs1387074545 1909 dbSNP
rs1425060865 1920 dbSNP
rs1032254294 1941 dbSNP
rs1408254355 1943 dbSNP
rs1330926855 1960 dbSNP
rs998649328 1986 dbSNP
rs1244631254 1996 dbSNP
rs1282933880 2020 dbSNP
rs1362305656 2034 dbSNP
rs376761100 2036 dbSNP
rs868929549 2045 dbSNP
rs1247137087 2063 dbSNP
rs1274435751 2079 dbSNP
rs1481842025 2085 dbSNP
rs782453158 2096 dbSNP
rs1250544391 2112 dbSNP
rs904239508 2116 dbSNP
rs1021304833 2136 dbSNP
rs782031363 2186 dbSNP
rs1441323457 2190 dbSNP
rs1184861413 2197 dbSNP
rs1012562992 2206 dbSNP
rs1445215105 2216 dbSNP
rs1167673216 2226 dbSNP
rs1388119610 2230 dbSNP
rs894409677 2238 dbSNP
rs1169888246 2246 dbSNP
rs782810747 2249 dbSNP
rs1395524170 2259 dbSNP
rs1334843374 2266 dbSNP
rs1003185647 2304 dbSNP
rs1454007881 2307 dbSNP
rs1297273873 2318 dbSNP
rs782066375 2335 dbSNP
rs886982937 2336 dbSNP
rs1251523594 2341 dbSNP
rs1343902069 2351 dbSNP
rs1198206707 2352 dbSNP
rs1244466092 2353 dbSNP
rs1461679036 2356 dbSNP
rs1187854633 2389 dbSNP
rs1245899628 2393 dbSNP
rs1430074251 2396 dbSNP
rs782186437 2409 dbSNP
rs1373831855 2427 dbSNP
rs782431697 2428 dbSNP
rs1465776591 2432 dbSNP
rs781920792 2448 dbSNP
rs782356165 2453 dbSNP
rs1408431975 2468 dbSNP
rs782626935 2475 dbSNP
rs181928320 2497 dbSNP
rs1320491447 2517 dbSNP
rs943404988 2519 dbSNP
rs910537181 2542 dbSNP
rs1360572194 2547 dbSNP
rs1384241916 2555 dbSNP
rs1296803102 2562 dbSNP
rs1221335514 2566 dbSNP
rs1330097172 2566 dbSNP
rs1264383582 2583 dbSNP
rs1323637174 2587 dbSNP
rs1207622863 2589 dbSNP
rs190626836 2590 dbSNP
rs987779814 2593 dbSNP
rs1486831406 2604 dbSNP
rs1205485026 2613 dbSNP
rs781876623 2618 dbSNP
rs1266436141 2620 dbSNP
rs955121795 2625 dbSNP
rs1432782882 2640 dbSNP
rs782162269 2645 dbSNP
rs1197543375 2666 dbSNP
rs184853719 2673 dbSNP
rs924812735 2679 dbSNP
rs977954621 2682 dbSNP
rs968473546 2686 dbSNP
rs1021355503 2694 dbSNP
rs781990995 2696 dbSNP
rs1480802036 2707 dbSNP
rs1012657841 2708 dbSNP
rs1343923180 2711 dbSNP
rs1455824444 2713 dbSNP
rs1289774308 2714 dbSNP
rs958382534 2731 dbSNP
rs1402646948 2740 dbSNP
rs1284786636 2763 dbSNP
rs1345828190 2786 dbSNP
rs1304297767 2837 dbSNP
rs1318606097 2843 dbSNP
rs1216449911 2845 dbSNP
rs1264570931 2847 dbSNP
rs1487390717 2871 dbSNP
rs1035759329 2873 dbSNP
rs1002823900 2875 dbSNP
rs1271278671 2878 dbSNP
rs886989684 2882 dbSNP
rs1490588342 2901 dbSNP
rs1181486751 2908 dbSNP
rs1405920980 2911 dbSNP
rs1421326771 2914 dbSNP
rs1160481813 2916 dbSNP
rs1046894305 2922 dbSNP
rs1423128436 2930 dbSNP
rs1305387178 2936 dbSNP
rs1365790200 2940 dbSNP
rs192040271 2955 dbSNP
rs1295907844 2963 dbSNP
rs781887802 2971 dbSNP
rs1374887155 2979 dbSNP
rs1224213851 2997 dbSNP
rs1311904603 2999 dbSNP
rs189054269 3006 dbSNP
rs1247870955 3008 dbSNP
rs1292254166 3017 dbSNP
rs1360387575 3041 dbSNP
rs1204094913 3044 dbSNP
rs1231186596 3046 dbSNP
rs781916483 3051 dbSNP
rs1481649097 3063 dbSNP
rs1177919498 3065 dbSNP
rs782380728 3069 dbSNP
rs1443383508 3081 dbSNP
rs1165812587 3085 dbSNP
rs1386284960 3086 dbSNP
rs1428635099 3093 dbSNP
rs1167899372 3143 dbSNP
rs1037775920 3161 dbSNP
rs1442296612 3169 dbSNP
rs1301804098 3180 dbSNP
rs1380427235 3182 dbSNP
rs1315395225 3183 dbSNP
rs1454541006 3183 dbSNP
rs373776926 3190 dbSNP
rs1364205595 3193 dbSNP
rs1212643287 3195 dbSNP
rs1271136415 3201 dbSNP
rs1309531010 3213 dbSNP
rs943457324 3233 dbSNP
rs1205285844 3251 dbSNP
rs910587523 3252 dbSNP
rs1460342743 3290 dbSNP
rs1185970941 3297 dbSNP
rs1244068586 3312 dbSNP
rs782303614 3313 dbSNP
rs183885948 3333 dbSNP
rs1185213754 3334 dbSNP
rs1421176235 3344 dbSNP
rs140147561 3353 dbSNP
rs1174694225 3361 dbSNP
rs1403270578 3368 dbSNP
rs1470880440 3370 dbSNP
rs1337294613 3385 dbSNP
rs924834710 3389 dbSNP
rs1428344202 3394 dbSNP
rs1271769293 3410 dbSNP
rs782727798 3411 dbSNP
rs1215416078 3414 dbSNP
rs1282653998 3425 dbSNP
rs1321525885 3448 dbSNP
rs1205713986 3466 dbSNP
rs1446973577 3468 dbSNP
rs1214027704 3472 dbSNP
rs1244224365 3478 dbSNP
rs1475499151 3497 dbSNP
rs1198251597 3499 dbSNP
rs782128203 3501 dbSNP
rs1481128120 3502 dbSNP
rs782284978 3505 dbSNP
rs781978694 3510 dbSNP
rs1398907213 3513 dbSNP
rs914724621 3513 dbSNP
rs1345573910 3532 dbSNP
rs1431682361 3536 dbSNP
rs1302767848 3548 dbSNP
rs1343945954 3552 dbSNP
rs1225396665 3557 dbSNP
rs991275907 3561 dbSNP
rs1284025208 3575 dbSNP
rs958433636 3582 dbSNP
rs1222568988 3609 dbSNP
rs1286712152 3611 dbSNP
rs1447921777 3622 dbSNP
rs1222294163 3624 dbSNP
rs1266285415 3664 dbSNP
rs1490751692 3694 dbSNP
rs1199450246 3716 dbSNP
rs1362743876 3719 dbSNP
rs1035368137 3721 dbSNP
rs1468481103 3722 dbSNP
rs1002911589 3725 dbSNP
rs1408704992 3729 dbSNP
rs951347151 3735 dbSNP
rs1026012283 3736 dbSNP
rs782411260 3737 dbSNP
rs1363921799 3748 dbSNP
rs192927291 3749 dbSNP
rs781925149 3783 dbSNP
rs898376523 3784 dbSNP
rs1440185825 3803 dbSNP
rs1018055184 3808 dbSNP
rs1352083992 3842 dbSNP
rs1245671562 3878 dbSNP
rs1290075973 3891 dbSNP
rs1007606502 3899 dbSNP
rs1361105403 3928 dbSNP
rs1222781042 3948 dbSNP
rs1249146632 3959 dbSNP
rs1435555537 3965 dbSNP
rs1233357084 3972 dbSNP
rs782364406 3972 dbSNP
rs1443988376 3983 dbSNP
rs889160499 3984 dbSNP
rs782221777 4010 dbSNP
rs1161395598 4017 dbSNP
rs374610596 4023 dbSNP
rs782658160 4025 dbSNP
rs1426722987 4042 dbSNP
rs187433638 4043 dbSNP
rs1396124070 4062 dbSNP
rs1408242948 4068 dbSNP
rs782299908 4088 dbSNP
rs782445671 4089 dbSNP
rs1331029276 4091 dbSNP
rs1336816834 4096 dbSNP
rs1452593769 4115 dbSNP
rs933287432 4118 dbSNP
rs903170181 4121 dbSNP
rs1042013807 4125 dbSNP
rs1250410320 4126 dbSNP
rs1337085640 4146 dbSNP
rs1197012852 4175 dbSNP
rs1273126964 4176 dbSNP
rs1181688834 4178 dbSNP
rs1460764439 4178 dbSNP
rs1244954210 4184 dbSNP
rs1445012765 4191 dbSNP
rs1192251139 4194 dbSNP
rs1372695489 4199 dbSNP
rs782676921 4200 dbSNP
rs1460676075 4204 dbSNP
rs1169687412 4205 dbSNP
rs1401134217 4207 dbSNP
rs1469690580 4209 dbSNP
rs1335305209 4214 dbSNP
rs141694648 4219 dbSNP
rs782419115 4224 dbSNP
rs1295375656 4226 dbSNP
rs3213576 4229 dbSNP
rs2495795 4234 dbSNP
rs3213577 4239 dbSNP
rs879953859 4240 dbSNP
rs1195620638 4244 dbSNP
rs1204274177 4244 dbSNP
rs1259433693 4244 dbSNP
rs1264889217 4244 dbSNP
rs1291862005 4244 dbSNP
rs1461747620 4244 dbSNP
rs201443649 4244 dbSNP
rs531470908 4244 dbSNP
rs60166177 4244 dbSNP
rs782233800 4244 dbSNP
rs1298427937 4249 dbSNP
rs200175983 4249 dbSNP
rs868980012 4249 dbSNP
rs951146156 4250 dbSNP
rs782472291 4251 dbSNP
rs1238253828 4252 dbSNP
rs1197306063 4254 dbSNP
rs1205572497 4254 dbSNP
rs1258680160 4254 dbSNP
rs1264133646 4254 dbSNP
rs1486719388 4254 dbSNP
rs868970881 4254 dbSNP
rs1025306618 4258 dbSNP
rs11798270 4259 dbSNP
rs1434201215 4259 dbSNP
rs1362634674 4267 dbSNP
rs1455642864 4285 dbSNP
rs1159675291 4293 dbSNP
rs1364512016 4298 dbSNP
rs1402749202 4316 dbSNP
rs1304358330 4323 dbSNP
rs1367714114 4327 dbSNP
rs973995788 4334 dbSNP
rs1304783962 4355 dbSNP
rs1318704268 4366 dbSNP
rs1240575173 4369 dbSNP
rs1290787671 4370 dbSNP
rs1358948793 4373 dbSNP
rs962571965 4381 dbSNP
rs1271390968 4402 dbSNP
rs1488845146 4404 dbSNP
rs1176728156 4416 dbSNP
rs1249006084 4429 dbSNP
rs1421416095 4431 dbSNP
rs781865593 4439 dbSNP
rs1179604578 4447 dbSNP
rs1385009131 4468 dbSNP
rs1422304030 4471 dbSNP
rs1165075063 4478 dbSNP
rs1018068165 4479 dbSNP
rs1350180508 4487 dbSNP
rs1461020308 4496 dbSNP
rs1295996499 4497 dbSNP
rs1375380895 4503 dbSNP
rs1447465997 4505 dbSNP
rs1006656963 4521 dbSNP
rs1314025718 4524 dbSNP
rs1380286300 4555 dbSNP
rs889221485 4556 dbSNP
rs1322604945 4561 dbSNP
rs1203842158 4573 dbSNP
rs1249719122 4586 dbSNP
rs1030859822 4598 dbSNP
rs1459427806 4602 dbSNP
rs1199833655 4604 dbSNP
rs782754476 4641 dbSNP
rs1243133493 4647 dbSNP
rs1443162190 4654 dbSNP
rs1185858375 4656 dbSNP
rs997590924 4664 dbSNP
rs903220124 4665 dbSNP
rs1167654100 4671 dbSNP
rs879984379 4672 dbSNP
rs782603137 4680 dbSNP
rs1355778583 4684 dbSNP
rs1466026880 4687 dbSNP
rs1335994743 4691 dbSNP
rs1403866738 4699 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Article - Uchida Y; Chiyomaru T; Enokida H; Kawakami et al.
- Urologic oncology, 2013
OBJECTIVE: We previously demonstrated that miR-133a is a tumor-suppressive microRNA (miRNA) and is commonly down-regulated in human bladder cancer (BC). The aim of this study is to determine a novel oncogenic gene targeted by miR-133a in BC. METHODS: To identify genes targeted by miR-133a, an oligo-microarray analysis was performed using the miR-133a-transfected BC cell lines. For gain/loss-of-function studies, miR-133a/si-glutathione S-transferase pi1 (GSTP1)-transfectants were subjected to XTT assay and flow cytometry to evaluate their cell viability and apoptosis status. The luciferase reporter assay was used to confirm the actual binding sites between miR-133a and GSTP1 mRNA. The mRNA and protein expression of GSTP1 in BC cell lines and clinical samples were evaluated by real-time RT-PCR and Western blot, respectively. RESULTS: MiR-133a transfection induced cell viability inhibition and apoptosis in BC cell lines. We focused on the GSTP1 gene that was the top 7 down-regulated one in the gene profile from the miR-133a-transfectants. MiR-133a transfection repressed expression levels of mRNA and protein levels of GSTP1. A luciferase reporter assay suggested that the actual binding may occur between miR-133a and GSTP1 mRNA. Cell viability inhibition and apoptosis were induced in the si-GSTP1 transfectants compared with the controls (P < 0.005). GSTP1 mRNA expression levels in 43 clinical BCs were significantly higher than those in eight normal bladder epitheliums (P = 0.0277). CONCLUSION: Our data suggest that tumor suppressive miR-133a directly regulated oncogenic GSTP1 gene in BC, and that an anti-apoptotic effect mediated by GSTP1 is maintained by miR-133a down-regulation in human BC.
LinkOut: [PMID: 21396852]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
STAD 0.486 0 0.454 0 32 Click to see details
BLCA 0.437 0.03 0.370 0.07 18 Click to see details
HNSC -0.166 0.15 -0.217 0.08 42 Click to see details
KICH 0.218 0.15 0.135 0.26 24 Click to see details
LUSC 0.153 0.18 0.171 0.15 38 Click to see details
CHOL 0.289 0.23 0.300 0.22 9 Click to see details
BRCA -0.082 0.24 -0.010 0.47 77 Click to see details
ESCA 0.224 0.25 0.436 0.09 11 Click to see details
LIHC 0.096 0.26 -0.039 0.4 49 Click to see details
UCEC -0.153 0.27 -0.198 0.21 19 Click to see details
KIRP 0.107 0.29 0.066 0.36 30 Click to see details
THCA 0.072 0.29 -0.087 0.26 59 Click to see details
COAD 0.226 0.3 0.190 0.33 8 Click to see details
PAAD -0.326 0.34 -0.800 0.1 4 Click to see details
LUAD -0.12 0.36 -0.126 0.35 12 Click to see details
PRAD 0.051 0.36 0.130 0.18 50 Click to see details
CESC -0.41 0.37 -0.500 0.33 3 Click to see details
KIRC 0.03 0.4 0.002 0.49 67 Click to see details
PCPG -0.043 0.49 0.500 0.33 3 Click to see details
PCPG -0.043 0.49 0.500 0.33 3 Click to see details
PCPG -0.043 0.49 0.500 0.33 3 Click to see details
122 hsa-miR-133a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000325 RHOA ras homolog family member A 1 2
MIRT000327 CDC42 cell division cycle 42 4 2
MIRT000328 ERG ERG, ETS transcription factor 1 1
MIRT000329 HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 2 1
MIRT000330 UCP2 uncoupling protein 2 2 2
MIRT000331 KRT7 keratin 7 2 2
MIRT001203 CACNA1C calcium voltage-gated channel subunit alpha1 C 3 1
MIRT001204 HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 4 2
MIRT001816 PKM pyruvate kinase, muscle 1 1
MIRT001986 CASP9 caspase 9 3 3
MIRT002925 KCNQ1 potassium voltage-gated channel subfamily Q member 1 4 1
MIRT003542 FSCN1 fascin actin-bundling protein 1 5 4
MIRT004831 KCNH2 potassium voltage-gated channel subfamily H member 2 4 1
MIRT005604 TAGLN2 transgelin 2 5 4
MIRT005813 LASP1 LIM and SH3 protein 1 3 2
MIRT006571 PNP purine nucleoside phosphorylase 4 2
MIRT006680 MSN moesin 2 1
MIRT007032 EGFR epidermal growth factor receptor 3 5
MIRT007088 VKORC1 vitamin K epoxide reductase complex subunit 1 1 1
MIRT007383 PRDM16 PR/SET domain 16 1 2
MIRT021693 TPM1 tropomyosin 1 1 1
MIRT021695 FBN1 fibrillin 1 1 1
MIRT021696 FAM120C family with sequence similarity 120C 1 1
MIRT021697 BCAN brevican 1 1
MIRT021698 TCTEX1D2 Tctex1 domain containing 2 1 1
MIRT021699 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 1 1
MIRT021700 RFT1 RFT1 homolog 1 1
MIRT021701 SENP1 SUMO1/sentrin specific peptidase 1 1 1
MIRT021702 SMIM14 small integral membrane protein 14 1 1
MIRT021703 PRELID1 PRELI domain containing 1 1 1
MIRT021704 CNN2 calponin 2 3 3
MIRT021705 ARPC5 actin related protein 2/3 complex subunit 5 4 2
MIRT021706 FTL ferritin light chain 2 2
MIRT021707 CERS2 ceramide synthase 2 1 1
MIRT021708 SEC61B Sec61 translocon beta subunit 1 1
MIRT021709 PLEKHA3 pleckstrin homology domain containing A3 1 1
MIRT021710 EGFL7 EGF like domain multiple 7 1 1
MIRT021711 VEGFA vascular endothelial growth factor A 1 1
MIRT021712 PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 1 1
MIRT021713 RGS3 regulator of G protein signaling 3 1 1
MIRT021714 COL1A1 collagen type I alpha 1 chain 4 1
MIRT021715 GSTP1 glutathione S-transferase pi 1 2 1
MIRT035537 SP1 Sp1 transcription factor 2 2
MIRT035579 KLF15 Kruppel like factor 15 1 1
MIRT045837 NR4A2 nuclear receptor subfamily 4 group A member 2 1 1
MIRT052647 BCL2L1 BCL2 like 1 4 2
MIRT052648 MCL1 MCL1, BCL2 family apoptosis regulator 4 2
MIRT053333 RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase 4 1
MIRT054310 IGF1R insulin like growth factor 1 receptor 3 2
MIRT055599 FAM160B1 family with sequence similarity 160 member B1 2 2
MIRT081957 UBA2 ubiquitin like modifier activating enzyme 2 4 1
MIRT437400 MMP14 matrix metallopeptidase 14 3 1
MIRT437953 ANXA2 annexin A2 4 1
MIRT437954 SNX30 sorting nexin family member 30 4 1
MIRT437955 SGMS2 sphingomyelin synthase 2 4 1
MIRT438719 PDLIM5 PDZ and LIM domain 5 3 1
MIRT452802 PACS2 phosphofurin acidic cluster sorting protein 2 2 2
MIRT462823 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT468494 SESN2 sestrin 2 2 2
MIRT477714 EFHD2 EF-hand domain family member D2 2 2
MIRT483852 EMID1 EMI domain containing 1 2 2
MIRT490039 PRRT2 proline rich transmembrane protein 2 2 2
MIRT491349 CDKN1A cyclin dependent kinase inhibitor 1A 2 4
MIRT504443 MC2R melanocortin 2 receptor 2 2
MIRT505701 SESN3 sestrin 3 2 2
MIRT513521 RHOQ ras homolog family member Q 2 4
MIRT517423 HIST2H2AC histone cluster 2 H2A family member c 2 2
MIRT526599 DCAKD dephospho-CoA kinase domain containing 2 2
MIRT528904 THBS2 thrombospondin 2 2 2
MIRT533060 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT534126 SNX33 sorting nexin 33 2 2
MIRT534700 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 4
MIRT535732 MYPN myopalladin 2 2
MIRT538529 CHMP3 charged multivesicular body protein 3 2 4
MIRT550878 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT551260 PSMG1 proteasome assembly chaperone 1 2 2
MIRT551981 UGT2B10 UDP glucuronosyltransferase family 2 member B10 2 2
MIRT553866 SYAP1 synapse associated protein 1 2 2
MIRT558810 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 2
MIRT559367 ATP13A3 ATPase 13A3 2 2
MIRT560941 ZFP28 ZFP28 zinc finger protein 2 2
MIRT565461 SUPT16H SPT16 homolog, facilitates chromatin remodeling subunit 2 2
MIRT566234 PTMA prothymosin, alpha 2 2
MIRT568217 C11orf24 chromosome 11 open reading frame 24 2 2
MIRT608912 NCDN neurochondrin 2 6
MIRT613229 CCDC39 coiled-coil domain containing 39 2 2
MIRT623563 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT637224 TMEM59 transmembrane protein 59 2 2
MIRT641669 CCNI cyclin I 2 2
MIRT644440 ALDOC aldolase, fructose-bisphosphate C 2 2
MIRT644755 TXNRD3NB thioredoxin reductase 3 neighbor 2 2
MIRT646711 PDE1A phosphodiesterase 1A 2 2
MIRT647577 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT647760 RNF168 ring finger protein 168 2 2
MIRT649267 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT651238 ZMAT4 zinc finger matrin-type 4 2 2
MIRT652146 TRIM71 tripartite motif containing 71 2 2
MIRT657168 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT668302 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 2
MIRT687546 MLEC malectin 2 2
MIRT690857 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT697060 PSMC4 proteasome 26S subunit, ATPase 4 2 2
MIRT699725 SERPINH1 serpin family H member 1 2 2
MIRT700858 PER2 period circadian clock 2 2 2
MIRT705068 C4orf29 abhydrolase domain containing 18 2 2
MIRT709496 ANGPT4 angiopoietin 4 2 2
MIRT713925 PIGR polymeric immunoglobulin receptor 2 2
MIRT716058 SFTPB surfactant protein B 2 2
MIRT716724 APOL6 apolipoprotein L6 2 2
MIRT721677 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT723379 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT731340 IGF1 insulin like growth factor 1 1 1
MIRT731591 ZEB1 zinc finger E-box binding homeobox 1 1 1
MIRT732526 PTBP1 polypyrimidine tract binding protein 1 2 0
MIRT732527 KDM5C lysine demethylase 5C 2 0
MIRT732589 BCL2 BCL2, apoptosis regulator 2 0
MIRT732590 CASP3 caspase 3 2 0
MIRT733594 PPP2CA protein phosphatase 2 catalytic subunit alpha 3 0
MIRT735355 MB myoglobin 1 0
MIRT735744 CDCA8 cell division cycle associated 8 3 0
MIRT736984 SET SET nuclear proto-oncogene 1 0
MIRT737550 TGFB1 transforming growth factor beta 1 4 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-133a Catechin approved 9064 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-133a Proanthocyanin NULL 108065 Microarray apoE−/− mice 22253797 2012 up-regulated
miR-133a Sulfonyl-hydrazone-1 (SHZ) NULL NULL Quantitative real-time PCR Murine broblast-derived Induced pluripotent stem cells 21445862 2011 up-regulated
miR-133a Atorvastatin approved 60823 Quantitative real-time PCR Cardiomyocyte 23860036 2013 down-regualted
miR-133a Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miR-133a Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miR-133a Benzene NULL 241 MiRNA PCR array white blood cell 24780745 2014 down-regulated
miR-133a Benzene NULL 241 MiRNA PCR array blood mononuclear cells 24780745 2014 down-regulated
miR-133a Ibandronate approved 60852 Quantitative real-time PCR Periodontal ligament stem cells (PDLSCs) 21108928 2011 down-regulated
miR-133a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-133a Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-133a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 down-regulated
miR-133a Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 up-regulated
miR-133a Thiourea (TU) NULL 737139 Quantitative real-time PCR skeletal muscle and heart 22142802 2012 down-regulated
miR-133a 5-Fluorouracil approved 3385 Quantitative real-time PCR colon cancer cells 17702597 2007 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H358, H1993)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H1155, H358, H1993)
hsa-miR-133a-3p Sunitinib 5329102 NSC750690 approved resistant High Metastatic Renal Cell Carcinoma tissue and cell line (Caki-2)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant Low Esophageal Squamous Cell Carcinoma tissue
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Head And Neck Squamous Cell Carcinoma cell line (Hep-2, NP69)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer tissue
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Urothelial Bladder Cancer cell line (T24)
hsa-miR-133a-3p Gemcitabine 60750 NSC613327 approved sensitive Low Urothelial Bladder Cancer cell line (T24)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant Low Prostate Cancer cell line (PC-3-R)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved sensitive Low Nasopharyngeal Cancer cell line (HONE1, SUNE1)
hsa-miR-133a-3p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer cell line (MGC-803)
hsa-miR-133a-3p Bromocriptine 31101 NSC169774 approved resistant Low Prolactinoma tissue
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-133a-3p Gefitinib 123631 NSC715055 approved sensitive Low Non-Small Cell Lung Cancer cell line (PC-9)
hsa-miR-133a-3p Doxorubicin 31703 NSC123127 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Etoposide 36462 NSC141540 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Vinorelbine 44424639 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Vincristine 5978 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (SKOV3, A2780)
hsa-miR-133a-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-133a-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-133a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-133a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-133a-3p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-133a-3p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-133a-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-133a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-133a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-133a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine sensitive cell line (Bats-72)

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