miRTarBase - #MIRT026026


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pre-miRNA Information
pre-miRNA hsa-mir-196a-1   
Genomic Coordinates chr17: 48632490 - 48632559
Synonyms MIRN196-1, MIRN196A1, MIR196A1
Description Homo sapiens miR-196a-1 stem-loop
Comment Lagos-Quintana et al. .
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-196a-2   
Genomic Coordinates chr12: 53991738 - 53991847
Synonyms MIRN196-2, MIRN196A2, MIR196A2
Description Homo sapiens miR-196a-2 stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-196a-5p
Sequence 25| UAGGUAGUUUCAUGUUGUUGGG |46
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 6 17 - 48632548 29233923 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30188818 11 COSMIC
COSN30130427 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1449318187 1 dbSNP
rs1167097656 4 dbSNP
rs767877229 4 dbSNP
rs750731061 10 dbSNP
rs756640169 12 dbSNP
rs931027203 13 dbSNP
rs185070757 13 dbSNP
rs569910454 16 dbSNP
rs190478598 17 dbSNP
rs755062780 17 dbSNP
rs751887895 18 dbSNP
rs1422312414 20 dbSNP
rs372978481 21 dbSNP
rs1289240119 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol IKBKB   
Synonyms IKK-beta, IKK2, IKKB, IMD15, NFKBIKB
Description inhibitor of nuclear factor kappa B kinase subunit beta
Transcript NM_001190720   
Other Transcripts NM_001556   
Expression
Putative miRNA Targets on IKBKB
3'UTR of IKBKB
(miRNA target sites are highlighted)		 
>IKBKB|NM_001190720|3'UTR
   1 TGTGGGGGGACTCGACCCCCTGACATGGGGCAGCCCATAGCAGGCCTTGTGCAGTGGGGGGACTCGACCCCCTGACATGG
  81 GGCTGCCTGGAGCAGGCCGCGTGACGTGGGGCTGCCTGGCCGCGGCTCTCACATGGTGGTTCCTGCTGCACTGATGGCCC
 161 AGGGGTCTCTGGTATCCAGATGGAGCTCTCGCTTCCTCAGCAGCTGTGACTTTCACCCAGGACCCAGGACGCAGCCCTCC
 241 GTGGGCACTGCCGGCGCCTTGTCTGCACACTGGAGGTCCTCCATTACAGAGGCCCAGCGCACATCGCTGGCCCCACAAAC
 321 GTTCAGGGGTACAGCCATGGCAGCTCCTTCCTCTGCCGTGAGAAAAGTGCTTGGAGTACGGTTTGCCACACACGTGACTG
 401 GACAGTGTCCAATTCAAATCTTTCAGGGCAGAGTCCGAGCAGCGCTTGGTGACAGCCTGTCCTCTCCTGCTCTCCAAAGG
 481 CCCTGCTCCCTGTCCTCTCTCACTTTACAGCTTGTGTTTCTTCTGGATTCAGCTTCTCCTAAACAGACAGTTTAATTATA
 561 GTTGCGGCCTGGCCCCATCCTCACTTCCTCTTTTTATTTCACTGCTGCTAAAATTGTGTTTTTACCTACTACTTTGGTGG
 641 TTGTCCTCTTTTCGGCAAAGTTGGAGCGAGTGCCAAGCTCTCCATCTGTGGTCCTTTCTGCCAAGAGCGACTCATAGTAA
 721 CCAGGATGGGAGAGCAGCTGCCTTATTCTGAATCCCAAAAATTACTTGGGGGTGATTGTCACAGAGGAGGGACAGAAAGG
 801 GTATCTGCTGACCACCAGCCTGCCTACCCATGCCCATGTCTCCATTCCTGCTCAAGCGTGTGTGCTGGGCCGGGGAGTCC
 881 CTGTCTCTCACAGCATCTAGCAGTATTATTAAATGGATTCATTTTAAAAATAGCTCCTATATTTTGTAACATGTCTCAAA
 961 CACTCATACTGGGTTCCACAATCCACTGTTAGAATACCTATGGTTAGGGCTTCTGAACTAAAATAATGGAAAATTTTAAC
1041 AATTTGTATAGTGCCTGGATCATTACTAGTGCCATAACCCTGCTTCTTCAACATTTCACAGAACTTCTCTTTTATATAAA
1121 GGCAAGAGCACAAAATGAGTTCAGATGATCACAAACAGGTGAGTTTTGTTGGAGAAGAAAGTTGGAGTAGGAGACTTTCA
1201 CAAGTGGTTTCCATGGAGATAGAATGAAGCATTCTGTGGTCAAGTAAGTTTAGGGAGCTATTCATGTTTCACTTGCTTTG
1281 TGGAGATTCACACTATGCACTGGGAAAGTATCTGAAAAGTCTTATAATAAAGAAACAGGCTTAACTTTGTGTAAGAACAC
1361 TGTTTATCAATGTCATTTGGCTATAGAAACATTTTCTCCTGCTGATTGTGTGTGTGAAACATGTATTAACATTCCAATGA
1441 ACTAGCATTTAATAAAGCACAATTTTGGAAACCCTGGTAAATGACAGTGGGAAATAACACCCGAAAGGCAAGGACGGGCA
1521 GATTGGGGAGGGAAAGGATGTTGGGCTAAGGGCTGTGAGCTTATGTTACAGGCAACTGAGCCACTGAAGAATTTTGACGA
1601 AGAAAATGCCAACCAAAGCAGTCATTTTAAAAGTTTATGGCTGTTCAGTTACAGGACAAGTTGTGAAAAGAAAG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggguuGUUGUACUUUGAUGGAu 5'
               ::|||||:::||:||| 
Target 5' cccccTGACATGGGGCTGCCTg 3'
 68 - 89 137.00 -24.30
2 
miRNA  3' ggguUGUUGUACUUUGAUGGAu 5'
              :::||:||:::||:||| 
Target 5' ccgcGTGACGTGGGGCTGCCTg 3'
 97 - 118 134.00 -21.70
3 
miRNA  3' ggGUU--GUUGUACUUUGAUGGAu 5'
            |||  || ::| |:| ||||| 
Target 5' caCAATCCACTGTTAGAATACCTa 3'
 977 - 1000 130.00 -8.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30504063 53 COSMIC
COSN24311314 70 COSMIC
COSN31562517 80 COSMIC
COSN24401741 86 COSMIC
COSN30192211 109 COSMIC
COSN30192217 110 COSMIC
COSN30505529 125 COSMIC
COSN31493703 132 COSMIC
COSN31561975 254 COSMIC
COSN1365040 273 COSMIC
COSN31966296 306 COSMIC
COSN19731708 336 COSMIC
COSN1365041 358 COSMIC
COSN30682611 393 COSMIC
COSN30089715 463 COSMIC
COSN5681865 684 COSMIC
COSN22842175 704 COSMIC
COSN9262708 869 COSMIC
COSN9262709 1191 COSMIC
COSN2276335 1265 COSMIC
COSN8577221 1278 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs200330845 3 dbSNP
rs1207541310 4 dbSNP
rs1363591904 4 dbSNP
rs767853683 4 dbSNP
rs762696791 5 dbSNP
rs1423628839 7 dbSNP
rs373835648 9 dbSNP
rs751151171 10 dbSNP
rs1245744436 13 dbSNP
rs201269714 14 dbSNP
rs202224656 15 dbSNP
rs1314572216 16 dbSNP
rs781749402 16 dbSNP
rs200320303 20 dbSNP
rs1190241495 21 dbSNP
rs1047230219 27 dbSNP
rs1449247971 29 dbSNP
rs1280382141 30 dbSNP
rs371211963 31 dbSNP
rs201402040 32 dbSNP
rs1411767009 34 dbSNP
rs1314703885 36 dbSNP
rs756574798 39 dbSNP
rs778115250 50 dbSNP
rs749599516 52 dbSNP
rs771243791 53 dbSNP
rs1057741 54 dbSNP
rs1020370409 55 dbSNP
rs200298223 61 dbSNP
rs201181169 66 dbSNP
rs967492046 67 dbSNP
rs978756860 72 dbSNP
rs1032976791 78 dbSNP
rs199680842 80 dbSNP
rs1332337685 85 dbSNP
rs894508964 97 dbSNP
rs200758695 99 dbSNP
rs201847975 100 dbSNP
rs199682340 101 dbSNP
rs200665574 102 dbSNP
rs555051396 106 dbSNP
rs1198293731 107 dbSNP
rs1401210984 110 dbSNP
rs903005550 112 dbSNP
rs201622289 113 dbSNP
rs1453127725 116 dbSNP
rs934146069 121 dbSNP
rs199881086 122 dbSNP
rs200818066 123 dbSNP
rs1027247873 124 dbSNP
rs957235684 124 dbSNP
rs181422855 125 dbSNP
rs371084696 129 dbSNP
rs898804496 131 dbSNP
rs568751975 134 dbSNP
rs199990375 136 dbSNP
rs557997684 140 dbSNP
rs1316186026 147 dbSNP
rs1304785362 151 dbSNP
rs1225400456 157 dbSNP
rs1406407879 161 dbSNP
rs976221260 166 dbSNP
rs1396926863 169 dbSNP
rs1344066271 170 dbSNP
rs1294395861 173 dbSNP
rs1453491707 178 dbSNP
rs1204731024 187 dbSNP
rs201032413 191 dbSNP
rs202118433 192 dbSNP
rs1180468169 205 dbSNP
rs929074188 207 dbSNP
rs1475802642 213 dbSNP
rs577845678 215 dbSNP
rs200059646 218 dbSNP
rs1055697437 220 dbSNP
rs910060064 223 dbSNP
rs941606939 226 dbSNP
rs200851497 231 dbSNP
rs201783697 232 dbSNP
rs1467273896 233 dbSNP
rs200218265 234 dbSNP
rs1217807664 236 dbSNP
rs1354287740 237 dbSNP
rs866465689 238 dbSNP
rs70958394 240 dbSNP
rs775659098 241 dbSNP
rs1304341581 242 dbSNP
rs1373371781 245 dbSNP
rs17875738 247 dbSNP
rs1217887497 248 dbSNP
rs1381874842 249 dbSNP
rs1360248958 251 dbSNP
rs1276266401 252 dbSNP
rs200336072 253 dbSNP
rs1420739714 254 dbSNP
rs201418310 255 dbSNP
rs773150373 256 dbSNP
rs1032814053 257 dbSNP
rs1211848234 266 dbSNP
rs1260022974 279 dbSNP
rs199754384 284 dbSNP
rs1378870821 288 dbSNP
rs1193523242 293 dbSNP
rs1261657596 297 dbSNP
rs200976432 299 dbSNP
rs531097218 300 dbSNP
rs964057538 301 dbSNP
rs1412965234 303 dbSNP
rs997281695 304 dbSNP
rs1007889284 306 dbSNP
rs201441801 307 dbSNP
rs199657547 319 dbSNP
rs200560865 321 dbSNP
rs1342279878 322 dbSNP
rs201858324 327 dbSNP
rs1273696815 329 dbSNP
rs1473007638 330 dbSNP
rs773856585 331 dbSNP
rs550877176 336 dbSNP
rs1280635448 337 dbSNP
rs1348962004 338 dbSNP
rs1216358806 340 dbSNP
rs1362092556 344 dbSNP
rs908682127 347 dbSNP
rs200048057 358 dbSNP
rs200664132 359 dbSNP
rs1303548479 360 dbSNP
rs1194586097 361 dbSNP
rs756291627 369 dbSNP
rs201833459 370 dbSNP
rs199844219 373 dbSNP
rs201015542 374 dbSNP
rs984538580 377 dbSNP
rs937010700 380 dbSNP
rs546929428 381 dbSNP
rs1256558042 386 dbSNP
rs753070918 387 dbSNP
rs949910292 387 dbSNP
rs1350903211 392 dbSNP
rs566090154 394 dbSNP
rs910050249 395 dbSNP
rs941561823 403 dbSNP
rs754265891 413 dbSNP
rs1334552524 416 dbSNP
rs147482022 418 dbSNP
rs1291850165 421 dbSNP
rs1235640511 425 dbSNP
rs1286107699 427 dbSNP
rs555017525 431 dbSNP
rs1437991210 436 dbSNP
rs201846544 437 dbSNP
rs1054530423 438 dbSNP
rs199957605 444 dbSNP
rs200750621 445 dbSNP
rs1353320720 449 dbSNP
rs1206197921 450 dbSNP
rs202142707 450 dbSNP
rs1254357174 453 dbSNP
rs1289801839 458 dbSNP
rs1416845526 462 dbSNP
rs1449879928 476 dbSNP
rs950367359 477 dbSNP
rs1253781048 481 dbSNP
rs1439284883 483 dbSNP
rs1368974650 488 dbSNP
rs1181083953 492 dbSNP
rs1177056095 495 dbSNP
rs1365273634 497 dbSNP
rs200484139 498 dbSNP
rs201491309 499 dbSNP
rs1240120446 500 dbSNP
rs202198059 512 dbSNP
rs1403169391 517 dbSNP
rs1199458134 530 dbSNP
rs1468231780 533 dbSNP
rs1397932797 535 dbSNP
rs1271556740 539 dbSNP
rs200234471 540 dbSNP
rs568875980 545 dbSNP
rs934726658 549 dbSNP
rs201560770 551 dbSNP
rs537980574 562 dbSNP
rs1237539792 564 dbSNP
rs199674990 566 dbSNP
rs892958788 567 dbSNP
rs186362479 571 dbSNP
rs1393252062 573 dbSNP
rs201253649 574 dbSNP
rs1323548168 575 dbSNP
rs199751650 576 dbSNP
rs1224948800 580 dbSNP
rs200969166 583 dbSNP
rs1250477397 585 dbSNP
rs201809170 591 dbSNP
rs1205033948 596 dbSNP
rs199635743 602 dbSNP
rs1251366184 614 dbSNP
rs1224051617 616 dbSNP
rs1452491198 619 dbSNP
rs1004393922 627 dbSNP
rs1356428830 632 dbSNP
rs200413060 632 dbSNP
rs201581925 640 dbSNP
rs1287426377 641 dbSNP
rs34177950 643 dbSNP
rs1240225612 649 dbSNP
rs1240677542 654 dbSNP
rs1272650560 662 dbSNP
rs1461290279 667 dbSNP
rs200049942 668 dbSNP
rs200856609 669 dbSNP
rs1264454885 671 dbSNP
rs950425375 679 dbSNP
rs140016896 683 dbSNP
rs1170189670 684 dbSNP
rs1434105475 685 dbSNP
rs920351952 695 dbSNP
rs1015995972 701 dbSNP
rs1478495974 709 dbSNP
rs199861667 710 dbSNP
rs991648406 711 dbSNP
rs201373746 717 dbSNP
rs202105886 723 dbSNP
rs1287363873 730 dbSNP
rs1210807840 739 dbSNP
rs1346447872 744 dbSNP
rs971639392 749 dbSNP
rs991258868 754 dbSNP
rs200259853 769 dbSNP
rs1269285398 770 dbSNP
rs1397903849 786 dbSNP
rs1174405569 790 dbSNP
rs1405488953 791 dbSNP
rs190717502 798 dbSNP
rs934674372 799 dbSNP
rs1298669041 811 dbSNP
rs1289431815 818 dbSNP
rs1054534043 831 dbSNP
rs1357459016 837 dbSNP
rs1041637104 839 dbSNP
rs1363982669 843 dbSNP
rs1415160638 848 dbSNP
rs554119772 854 dbSNP
rs202143222 858 dbSNP
rs200355207 859 dbSNP
rs1331350950 860 dbSNP
rs1484996511 872 dbSNP
rs943448605 873 dbSNP
rs1211596077 878 dbSNP
rs1442556907 894 dbSNP
rs1260832656 898 dbSNP
rs201486499 904 dbSNP
rs1216423218 915 dbSNP
rs145467277 935 dbSNP
rs901705669 941 dbSNP
rs10108113 944 dbSNP
rs1232495483 947 dbSNP
rs562143571 967 dbSNP
rs1304572686 968 dbSNP
rs1448844037 969 dbSNP
rs1051137764 971 dbSNP
rs886093562 973 dbSNP
rs1186314735 982 dbSNP
rs750967880 989 dbSNP
rs200299577 998 dbSNP
rs1424741530 1001 dbSNP
rs1164624839 1002 dbSNP
rs1474462104 1003 dbSNP
rs1005813263 1004 dbSNP
rs1268442121 1011 dbSNP
rs1015901844 1012 dbSNP
rs1483255315 1028 dbSNP
rs201777013 1040 dbSNP
rs199657942 1048 dbSNP
rs959113423 1049 dbSNP
rs200548523 1054 dbSNP
rs1004194107 1059 dbSNP
rs201345919 1062 dbSNP
rs1012418901 1066 dbSNP
rs544738195 1069 dbSNP
rs1197594785 1080 dbSNP
rs199563764 1091 dbSNP
rs1428842213 1100 dbSNP
rs34793002 1107 dbSNP
rs1319775530 1113 dbSNP
rs145169825 1114 dbSNP
rs1161295874 1115 dbSNP
rs1372642228 1116 dbSNP
rs1307219055 1118 dbSNP
rs1346909513 1136 dbSNP
rs1449146023 1138 dbSNP
rs1401279421 1148 dbSNP
rs780717347 1160 dbSNP
rs201822375 1166 dbSNP
rs200035161 1173 dbSNP
rs200923477 1180 dbSNP
rs1351995623 1188 dbSNP
rs1419034208 1202 dbSNP
rs1379042818 1204 dbSNP
rs373965574 1214 dbSNP
rs202045103 1221 dbSNP
rs199983960 1225 dbSNP
rs200975481 1229 dbSNP
rs149139440 1237 dbSNP
rs956291035 1239 dbSNP
rs1267018487 1242 dbSNP
rs1406522959 1242 dbSNP
rs1222166916 1249 dbSNP
rs995690314 1253 dbSNP
rs1283862992 1255 dbSNP
rs1281048592 1259 dbSNP
rs554424235 1279 dbSNP
rs1377834132 1283 dbSNP
rs990108179 1285 dbSNP
rs1302873889 1287 dbSNP
rs1385328040 1293 dbSNP
rs202052842 1294 dbSNP
rs1223860999 1304 dbSNP
rs200207727 1306 dbSNP
rs1294453580 1311 dbSNP
rs1453555632 1317 dbSNP
rs914563557 1326 dbSNP
rs1308450671 1329 dbSNP
rs1420915224 1335 dbSNP
rs943457780 1337 dbSNP
rs1315690707 1338 dbSNP
rs201369782 1340 dbSNP
rs142198097 1341 dbSNP
rs923109150 1346 dbSNP
rs1490959183 1353 dbSNP
rs1220711991 1354 dbSNP
rs373244977 1361 dbSNP
rs182602715 1362 dbSNP
rs971037262 1367 dbSNP
rs200387711 1370 dbSNP
rs1279741636 1392 dbSNP
rs1231208002 1396 dbSNP
rs201324109 1397 dbSNP
rs1382005569 1399 dbSNP
rs977116744 1399 dbSNP
rs1473008334 1405 dbSNP
rs1300524901 1409 dbSNP
rs199842325 1415 dbSNP
rs568863217 1423 dbSNP
rs200383405 1426 dbSNP
rs1464150697 1432 dbSNP
rs990091014 1438 dbSNP
rs201195467 1440 dbSNP
rs1418549555 1442 dbSNP
rs199692851 1466 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Article - Chen R; Alvero AB; Silasi DA; Kelly MG; et al.
- Oncogene, 2008
Cancer progression is an abnormal form of tissue repair characterized by chronic inflammation. IkappaB kinase-beta (IKKbeta) required for nuclear factor-kappaB (NF-kappaB) activation plays a critical role in this process. Using EOC cells isolated from malignant ovarian cancer ascites and solid tumors, we identified IKKbeta as a major factor promoting a functional TLR-MyD88-NF-kappaB pathway that confers to EOC cell the capacity to constitutively secrete proinflammatory/protumor cytokines and therefore promoting tumor progression and chemoresistance. Furthermore, we describe for the first time the identification of the microRNA hsa-miR-199a as a regulator of IKKbeta expression. Our study describes the property of ovarian cancer cells to enhance the inflammatory microenvironment as a result of the expression of an active IKKbeta pathway. Identification of these markers in patients' tumor samples may facilitate the adequate selection of treatment and open new venues for the development of effective therapy for chemoresistant ovarian cancers.
LinkOut: [PMID: 18408758]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer 0.354 2.3e-2 0.431 6.9e-3 32 Click to see details
GSE21032 Prostate cancer -0.211 2.8e-2 -0.222 2.2e-2 83 Click to see details
GSE14794 Lymphoblastoid cells -0.184 4.1e-2 -0.089 2.0e-1 90 Click to see details
GSE28544 Breast cancer 0.34 5.2e-2 0.492 7.3e-3 24 Click to see details
GSE26953 Aortic valvular endothelial cells 0.28 9.3e-2 0.006 4.9e-1 24 Click to see details
GSE27834 Pluripotent stem cells -0.284 1.4e-1 -0.341 9.8e-2 16 Click to see details
GSE19350 CNS germ cell tumors -0.295 1.8e-1 -0.252 2.1e-1 12 Click to see details
GSE21687 Ependynoma primary tumors -0.11 1.9e-1 -0.119 1.7e-1 64 Click to see details
GSE38226 Liver fibrosis -0.148 2.6e-1 -0.213 1.8e-1 21 Click to see details
GSE21849 B cell lymphoma -0.123 2.6e-1 -0.135 2.4e-1 29 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.202 3.0e-1 0.017 4.8e-1 9 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.097 3.4e-1 0.180 2.2e-1 20 Click to see details
GSE19783 ER- ER- breast cancer -0.044 3.5e-1 -0.041 3.6e-1 79 Click to see details
GSE19536 Breast cancer -0.037 3.6e-1 -0.026 4.0e-1 100 Click to see details
GSE17306 Multiple myeloma -0.046 3.8e-1 0.066 3.3e-1 49 Click to see details
GSE42095 Differentiated embryonic stem cells -0.068 3.8e-1 -0.295 8.6e-2 23 Click to see details
GSE17498 Multiple myeloma 0.05 3.8e-1 0.121 2.3e-1 40 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.03 4.4e-1 -0.034 4.4e-1 25 Click to see details
GSE19783 ER+ ER+ breast cancer 0.03 4.5e-1 0.156 2.6e-1 20 Click to see details
GSE28260 Renal cortex and medulla -0.026 4.7e-1 0.368 1.1e-1 13 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.009 4.8e-1 -0.053 4.0e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LIHC -0.363 0.01 -0.284 0.04 37 Click to see details
PCPG -0.996 0.03 -1.000 0.5 3 Click to see details
LUSC -0.292 0.04 -0.261 0.06 38 Click to see details
CHOL -0.498 0.1 -0.357 0.19 8 Click to see details
COAD 0.403 0.16 0.167 0.35 8 Click to see details
PRAD -0.14 0.17 -0.202 0.08 50 Click to see details
THCA 0.132 0.19 0.127 0.2 47 Click to see details
CESC 0.781 0.21 1.000 0.5 3 Click to see details
BRCA 0.087 0.22 0.091 0.21 84 Click to see details
KICH 0.159 0.22 0.212 0.15 25 Click to see details
KIRC 0.082 0.25 0.068 0.29 68 Click to see details
HNSC -0.077 0.31 -0.031 0.42 42 Click to see details
UCEC -0.088 0.36 -0.188 0.22 19 Click to see details
STAD -0.045 0.41 -0.002 0.5 31 Click to see details
BLCA 0.054 0.42 0.106 0.34 18 Click to see details
ESCA -0.058 0.43 -0.182 0.3 11 Click to see details
LUAD -0.056 0.44 0.027 0.47 11 Click to see details
PAAD -0.123 0.44 -0.400 0.3 4 Click to see details
KIRP -0.014 0.47 0.060 0.37 32 Click to see details
KIRP -0.014 0.47 0.060 0.37 32 Click to see details
KIRP -0.014 0.47 0.060 0.37 32 Click to see details
301 hsa-miR-196a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000218 BMP4 bone morphogenetic protein 4 1 1
MIRT000219 SPRR2C small proline rich protein 2C (pseudogene) 3 2
MIRT000220 S100A9 S100 calcium binding protein A9 3 2
MIRT000221 KRT5 keratin 5 3 2
MIRT000709 ANXA1 annexin A1 4 2
MIRT002266 HOXB8 homeobox B8 5 7
MIRT002940 HOXA7 homeobox A7 4 5
MIRT002941 HOXD8 homeobox D8 3 3
MIRT002942 HOXC8 homeobox C8 6 15
MIRT004244 HOXB7 homeobox B7 4 1
MIRT004718 BACH1 BTB domain and CNC homolog 1 6 3
MIRT004719 HMOX1 heme oxygenase 1 4 1
MIRT005065 CDKN1B cyclin dependent kinase inhibitor 1B 6 7
MIRT006802 HMGA1 high mobility group AT-hook 1 5 5
MIRT006803 HMGA2 high mobility group AT-hook 2 5 7
MIRT006906 HOXA5 homeobox A5 5 3
MIRT026026 IKBKB inhibitor of nuclear factor kappa B kinase subunit beta 1 1
MIRT026027 PDCD4 programmed cell death 4 1 1
MIRT026028 SRRT serrate, RNA effector molecule 2 9
MIRT026029 DIEXF digestive organ expansion factor homolog (zebrafish) 1 1
MIRT026030 ZBTB24 zinc finger and BTB domain containing 24 1 1
MIRT026031 NR4A1 nuclear receptor subfamily 4 group A member 1 1 1
MIRT026032 ABT1 activator of basal transcription 1 1 1
MIRT026033 SPATA2 spermatogenesis associated 2 1 1
MIRT026034 NHLRC3 NHL repeat containing 3 1 1
MIRT026035 RPUSD2 RNA pseudouridylate synthase domain containing 2 1 1
MIRT026036 CEP120 centrosomal protein 120 1 1
MIRT026037 PHC3 polyhomeotic homolog 3 1 1
MIRT026038 ZBTB6 zinc finger and BTB domain containing 6 1 1
MIRT026039 C9orf41 carnosine N-methyltransferase 1 1 1
MIRT026040 PNP purine nucleoside phosphorylase 1 1
MIRT026041 COPS3 COP9 signalosome subunit 3 1 1
MIRT026042 NUP50 nucleoporin 50 1 1
MIRT026043 ZNF763 zinc finger protein 763 1 1
MIRT026044 FOXJ3 forkhead box J3 1 1
MIRT026045 BIN3 bridging integrator 3 1 1
MIRT026046 C12orf4 chromosome 12 open reading frame 4 1 1
MIRT026047 RAD9A RAD9 checkpoint clamp component A 1 1
MIRT026048 PCGF3 polycomb group ring finger 3 1 1
MIRT026049 KATNAL1 katanin catalytic subunit A1 like 1 1 1
MIRT026050 SLC10A7 solute carrier family 10 member 7 1 1
MIRT026051 LBR lamin B receptor 1 1
MIRT026052 BCL11A B-cell CLL/lymphoma 11A 1 1
MIRT026053 GLMN glomulin, FKBP associated protein 1 1
MIRT026054 STK40 serine/threonine kinase 40 1 1
MIRT026055 TMEM135 transmembrane protein 135 1 1
MIRT026056 GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 2 3
MIRT026057 POLR2D RNA polymerase II subunit D 2 5
MIRT026058 LGR4 leucine rich repeat containing G protein-coupled receptor 4 1 1
MIRT026059 IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 2 4
MIRT026060 ESPL1 extra spindle pole bodies like 1, separase 1 1
MIRT026061 RFX5 regulatory factor X5 1 1
MIRT026062 SYT9 synaptotagmin 9 1 1
MIRT026063 PEX13 peroxisomal biogenesis factor 13 1 1
MIRT026064 IGF1R insulin like growth factor 1 receptor 1 1
MIRT026065 SMCR7L mitochondrial elongation factor 1 1 4
MIRT026066 SLC30A6 solute carrier family 30 member 6 2 3
MIRT026067 RAB31 RAB31, member RAS oncogene family 1 1
MIRT026068 KPNA5 karyopherin subunit alpha 5 1 1
MIRT026069 SLC20A1 solute carrier family 20 member 1 1 1
MIRT026070 TIMM23 translocase of inner mitochondrial membrane 23 1 1
MIRT026071 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT026072 SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 1 1
MIRT026073 CCNT2 cyclin T2 1 1
MIRT026074 CCND2 cyclin D2 1 1
MIRT026075 USP24 ubiquitin specific peptidase 24 1 1
MIRT026076 TRPC3 transient receptor potential cation channel subfamily C member 3 2 4
MIRT026077 SMC3 structural maintenance of chromosomes 3 1 1
MIRT026078 TMEM2 transmembrane protein 2 1 1
MIRT026079 RDH10 retinol dehydrogenase 10 1 1
MIRT026080 C11orf57 chromosome 11 open reading frame 57 2 5
MIRT026081 FAM127A retrotransposon Gag like 8C 2 4
MIRT026082 PRUNE2 prune homolog 2 2 3
MIRT026083 SPRYD4 SPRY domain containing 4 1 1
MIRT026084 TMEM161B transmembrane protein 161B 1 1
MIRT026085 CPEB3 cytoplasmic polyadenylation element binding protein 3 1 1
MIRT026086 FAM104A family with sequence similarity 104 member A 2 2
MIRT026087 RAB7L1 RAB29, member RAS oncogene family 1 1
MIRT026088 ITGAV integrin subunit alpha V 1 1
MIRT026089 CPD carboxypeptidase D 1 1
MIRT026090 ZNF354B zinc finger protein 354B 1 1
MIRT026091 TMEM194A nuclear envelope integral membrane protein 1 1 1
MIRT026092 EPHA7 EPH receptor A7 1 1
MIRT026093 KIAA1804 mitogen-activated protein kinase kinase kinase 21 1 1
MIRT026094 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT026095 TSPAN12 tetraspanin 12 1 1
MIRT026096 LIN28B lin-28 homolog B 1 1
MIRT026097 ARHGAP28 Rho GTPase activating protein 28 1 1
MIRT026098 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 1 1
MIRT026099 CCDC47 coiled-coil domain containing 47 1 1
MIRT026100 HAND1 heart and neural crest derivatives expressed 1 4 2
MIRT026101 LLGL1 LLGL1, scribble cell polarity complex component 1 1
MIRT048150 PGAM1 phosphoglycerate mutase 1 1 1
MIRT048151 PSMC3 proteasome 26S subunit, ATPase 3 1 1
MIRT048152 TMX2 thioredoxin related transmembrane protein 2 1 1
MIRT048153 KLHL7 kelch like family member 7 1 1
MIRT048154 RFC2 replication factor C subunit 2 1 1
MIRT048155 GLUL glutamate-ammonia ligase 1 1
MIRT048156 NRXN1 neurexin 1 1 1
MIRT048157 GSTK1 glutathione S-transferase kappa 1 1 1
MIRT048158 HIST2H4B histone cluster 2 H4 family member b 1 1
MIRT048159 SPEN spen family transcriptional repressor 1 1
MIRT048160 TAF15 TATA-box binding protein associated factor 15 1 1
MIRT048161 SAP18 Sin3A associated protein 18 1 1
MIRT048162 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 1 1
MIRT048163 MSL3 MSL complex subunit 3 1 1
MIRT048164 TSKU tsukushi, small leucine rich proteoglycan 1 1
MIRT048165 KMT2C lysine methyltransferase 2C 1 1
MIRT048166 LYRM2 LYR motif containing 2 1 1
MIRT048167 UBE2Z ubiquitin conjugating enzyme E2 Z 1 1
MIRT048168 C19orf55 proline and serine rich 3 1 1
MIRT048169 LRP2 LDL receptor related protein 2 1 1
MIRT048170 ND4L NADH dehydrogenase, subunit 4L (complex I) 1 1
MIRT048171 NKX6-1 NK6 homeobox 1 1 1
MIRT048172 BRMS1L breast cancer metastasis-suppressor 1 like 1 1
MIRT048173 RPS2 ribosomal protein S2 1 1
MIRT048174 RBMX RNA binding motif protein, X-linked 1 1
MIRT048175 ZFP64 ZFP64 zinc finger protein 1 1
MIRT048176 REEP2 receptor accessory protein 2 1 1
MIRT048177 MED13 mediator complex subunit 13 1 1
MIRT048178 MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 1 1
MIRT048179 TRAPPC9 trafficking protein particle complex 9 1 1
MIRT048180 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 1 1
MIRT048181 VDAC3 voltage dependent anion channel 3 1 1
MIRT048182 ZNF529 zinc finger protein 529 1 1
MIRT048183 EWSR1 EWS RNA binding protein 1 1 1
MIRT048184 ATP6V1B2 ATPase H+ transporting V1 subunit B2 1 1
MIRT048185 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 1 1
MIRT048186 APP amyloid beta precursor protein 1 1
MIRT048187 PROSER1 proline and serine rich 1 1 1
MIRT048188 HIST1H2BB histone cluster 1 H2B family member b 1 1
MIRT048189 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 1 1
MIRT048190 TUBA1B tubulin alpha 1b 1 1
MIRT048191 USP19 ubiquitin specific peptidase 19 1 1
MIRT048192 COX3 cytochrome c oxidase III 1 1
MIRT048193 PSMD8 proteasome 26S subunit, non-ATPase 8 1 1
MIRT048194 TRA2B transformer 2 beta homolog 1 1
MIRT048195 MRPL35 mitochondrial ribosomal protein L35 1 1
MIRT048196 KCTD1 potassium channel tetramerization domain containing 1 1 1
MIRT048197 UBE2C ubiquitin conjugating enzyme E2 C 1 1
MIRT048198 ZNF581 zinc finger protein 581 1 1
MIRT048199 CNOT11 CCR4-NOT transcription complex subunit 11 1 1
MIRT048200 POTEG POTE ankyrin domain family member G 1 1
MIRT048201 MTRF1L mitochondrial translational release factor 1 like 1 1
MIRT048202 SRP9 signal recognition particle 9 2 5
MIRT048203 BCORL1 BCL6 corepressor like 1 1 1
MIRT048204 NRBP1 nuclear receptor binding protein 1 1 1
MIRT048205 LRRC41 leucine rich repeat containing 41 1 1
MIRT048206 ATP6 ATP synthase F0 subunit 6 1 1
MIRT048207 FKTN fukutin 1 1
MIRT048208 RANBP9 RAN binding protein 9 1 1
MIRT048209 SYVN1 synoviolin 1 1 1
MIRT048210 NR2F6 nuclear receptor subfamily 2 group F member 6 1 1
MIRT048211 ATG16L1 autophagy related 16 like 1 1 1
MIRT048212 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 1 1
MIRT048213 ECHDC1 ethylmalonyl-CoA decarboxylase 1 1 1
MIRT048214 HAUS6 HAUS augmin like complex subunit 6 1 1
MIRT048215 CKAP2L cytoskeleton associated protein 2 like 1 1
MIRT048216 IFNGR1 interferon gamma receptor 1 1 1
MIRT048217 ANXA7 annexin A7 1 1
MIRT048218 ENAH ENAH, actin regulator 1 1
MIRT048219 FOXO1 forkhead box O1 9 3
MIRT048220 NDFIP1 Nedd4 family interacting protein 1 1 1
MIRT048221 LSM14A LSM14A, mRNA processing body assembly factor 1 1
MIRT048222 ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 1 1
MIRT048223 SLC25A17 solute carrier family 25 member 17 1 1
MIRT048224 ZNF398 zinc finger protein 398 1 1
MIRT048225 RASSF7 Ras association domain family member 7 1 1
MIRT048226 SBF1 SET binding factor 1 1 1
MIRT048227 TP53RK TP53 regulating kinase 1 1
MIRT048228 MED12 mediator complex subunit 12 1 1
MIRT048229 FLNA filamin A 1 1
MIRT048230 CCNE2 cyclin E2 1 1
MIRT048231 CANX calnexin 1 1
MIRT048232 PRPF8 pre-mRNA processing factor 8 1 1
MIRT048233 FRS2 fibroblast growth factor receptor substrate 2 1 1
MIRT048234 KIF18B kinesin family member 18B 1 1
MIRT048235 U2AF2 U2 small nuclear RNA auxiliary factor 2 1 1
MIRT048236 SH3GL3 SH3 domain containing GRB2 like 3, endophilin A3 1 1
MIRT048237 VCP valosin containing protein 1 1
MIRT048238 ETV3 ETS variant 3 1 1
MIRT048239 BCS1L BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone 1 1
MIRT048240 ND5 NADH dehydrogenase, subunit 5 (complex I) 1 1
MIRT048241 ZCCHC11 zinc finger CCHC-type containing 11 1 1
MIRT048242 RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 1 1
MIRT048243 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 1 1
MIRT048244 ACTB actin beta 1 1
MIRT048245 UQCRC2 ubiquinol-cytochrome c reductase core protein II 1 1
MIRT048246 EIF2B4 eukaryotic translation initiation factor 2B subunit delta 1 1
MIRT048247 GMFB glia maturation factor beta 1 1
MIRT048248 PALLD palladin, cytoskeletal associated protein 1 1
MIRT048249 CASP3 caspase 3 1 1
MIRT048250 VCL vinculin 1 1
MIRT048251 IPO5 importin 5 1 1
MIRT048252 PATL1 PAT1 homolog 1, processing body mRNA decay factor 1 1
MIRT048253 NAP1L4 nucleosome assembly protein 1 like 4 1 1
MIRT048254 RUFY2 RUN and FYVE domain containing 2 2 1
MIRT048255 TUBB tubulin beta class I 1 1
MIRT048256 CCND1 cyclin D1 1 1
MIRT048257 GID8 GID complex subunit 8 homolog 1 1
MIRT048258 VDAC2 voltage dependent anion channel 2 1 1
MIRT048259 SLC6A8 solute carrier family 6 member 8 1 1
MIRT048260 FXR2 FMR1 autosomal homolog 2 1 1
MIRT048261 SCN11A sodium voltage-gated channel alpha subunit 11 1 1
MIRT048262 AHSA1 activator of HSP90 ATPase activity 1 1 1
MIRT048263 ATG9A autophagy related 9A 1 1
MIRT048264 NOTCH2 notch 2 1 1
MIRT048265 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 1 1
MIRT048266 ND4 NADH dehydrogenase, subunit 4 (complex I) 2 1
MIRT048267 OAT ornithine aminotransferase 1 1
MIRT048268 TRAP1 TNF receptor associated protein 1 1 1
MIRT048269 SKI SKI proto-oncogene 1 1
MIRT048270 GLTP glycolipid transfer protein 1 1
MIRT048271 EEF2 eukaryotic translation elongation factor 2 1 1
MIRT048272 LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated 1 1
MIRT048273 GRIK4 glutamate ionotropic receptor kainate type subunit 4 1 1
MIRT048274 PDE6D phosphodiesterase 6D 1 1
MIRT048275 MPP2 membrane palmitoylated protein 2 1 1
MIRT048276 SAR1B secretion associated Ras related GTPase 1B 2 3
MIRT048277 MAP4 microtubule associated protein 4 1 1
MIRT048278 RAB21 RAB21, member RAS oncogene family 1 1
MIRT048279 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 1 1
MIRT048280 OGFRL1 opioid growth factor receptor like 1 1 1
MIRT048281 GOT2 glutamic-oxaloacetic transaminase 2 1 1
MIRT048282 NRDE2 NRDE-2, necessary for RNA interference, domain containing 1 1
MIRT048283 SBNO1 strawberry notch homolog 1 1 1
MIRT053067 NTN4 netrin 4 2 1
MIRT054025 RDX radixin 5 5
MIRT056750 ARID5B AT-rich interaction domain 5B 2 2
MIRT057645 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT076226 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 6
MIRT083303 ZCCHC3 zinc finger CCHC-type containing 3 2 2
MIRT095769 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT187720 SUOX sulfite oxidase 2 2
MIRT191923 CALM1 calmodulin 1 2 2
MIRT205504 SP100 SP100 nuclear antigen 2 2
MIRT209857 ACVR2B activin A receptor type 2B 2 2
MIRT229841 YIPF6 Yip1 domain family member 6 2 2
MIRT230833 TBRG1 transforming growth factor beta regulator 1 2 2
MIRT235376 CALM3 calmodulin 3 2 2
MIRT251626 KCNJ2 potassium voltage-gated channel subfamily J member 2 2 2
MIRT252333 SALL3 spalt like transcription factor 3 2 2
MIRT255317 CDV3 CDV3 homolog 2 2
MIRT324734 ACER2 alkaline ceramidase 2 4 3
MIRT386075 ZNF609 zinc finger protein 609 2 2
MIRT402060 ATP6V1F ATPase H+ transporting V1 subunit F 2 4
MIRT437422 NFKBIA NFKB inhibitor alpha 4 2
MIRT437980 TYMS thymidylate synthetase 1 1
MIRT437981 NRP2 neuropilin 2 1 1
MIRT437982 LSP1 lymphocyte-specific protein 1 1 1
MIRT439104 MYC MYC proto-oncogene, bHLH transcription factor 0 1
MIRT447143 KIF27 kinesin family member 27 2 2
MIRT447559 C14orf37 chromosome 14 open reading frame 37 2 2
MIRT449961 FMNL3 formin like 3 2 2
MIRT465087 TSPAN3 tetraspanin 3 2 2
MIRT470426 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 2
MIRT472726 MTUS1 microtubule associated scaffold protein 1 2 6
MIRT473801 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT474507 KLHDC8B kelch domain containing 8B 2 2
MIRT474917 KCTD21 potassium channel tetramerization domain containing 21 2 2
MIRT486549 DCTN4 dynactin subunit 4 2 2
MIRT492430 RGL2 ral guanine nucleotide dissociation stimulator like 2 2 2
MIRT493925 FAM127B retrotransposon Gag like 8A 2 4
MIRT500972 SPTSSA serine palmitoyltransferase small subunit A 2 2
MIRT501431 RAB11FIP4 RAB11 family interacting protein 4 2 2
MIRT502410 GATA6 GATA binding protein 6 2 8
MIRT506368 NUP155 nucleoporin 155 2 6
MIRT507497 E2F7 E2F transcription factor 7 2 6
MIRT520041 YOD1 YOD1 deubiquitinase 2 6
MIRT522366 NAP1L1 nucleosome assembly protein 1 like 1 2 4
MIRT531281 SLC7A7 solute carrier family 7 member 7 2 2
MIRT543674 FAM135A family with sequence similarity 135 member A 2 2
MIRT545199 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT546336 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT546452 SLC9A7 solute carrier family 9 member A7 2 2
MIRT546787 RCC2 regulator of chromosome condensation 2 2 4
MIRT547253 NXPE3 neurexophilin and PC-esterase domain family member 3 2 2
MIRT547454 MBD4 methyl-CpG binding domain 4, DNA glycosylase 2 2
MIRT547581 LRIG3 leucine rich repeats and immunoglobulin like domains 3 2 4
MIRT547902 HOXA9 homeobox A9 2 4
MIRT549503 ABHD2 abhydrolase domain containing 2 2 2
MIRT549583 ZNF850 zinc finger protein 850 2 2
MIRT551888 MMS22L MMS22 like, DNA repair protein 2 2
MIRT552125 MED10 mediator complex subunit 10 2 2
MIRT554188 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT555552 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT556285 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT556980 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT559183 BRAP BRCA1 associated protein 2 2
MIRT561215 ZSWIM1 zinc finger SWIM-type containing 1 2 2
MIRT562352 EXOC8 exocyst complex component 8 2 2
MIRT565603 SLC35G1 solute carrier family 35 member G1 2 2
MIRT575599 Gnl1 guanine nucleotide binding protein-like 1 2 3
MIRT610363 GNL1 G protein nucleolar 1 (putative) 2 3
MIRT617860 FMO4 flavin containing monooxygenase 4 2 2
MIRT698193 TMEM66 store-operated calcium entry associated regulatory factor 1 1
MIRT704411 CTPS1 CTP synthase 1 2 2
MIRT732864 NARS asparaginyl-tRNA synthetase 3 0
MIRT732867 AJAP1 adherens junctions associated protein 1 3 0
MIRT732868 COL24A1 collagen type XXIV alpha 1 chain 3 0
MIRT735738 RASSF4 Ras association domain family member 4 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-196a Curcumin NULL 969516 Microarray BxPC-3 human pancreatic carcinoma cell line 18347134 2008 down-regulated
miR-196a Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miR-196a Polylysine NULL 162282 Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
miR-196a Trypaflavine NULL NULL Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
miR-196a Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-196a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-196a Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-196a Narangin NULL 442428 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-196a Proanthocyanin NULL 108065 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-196a (S)-3,5-dihydroxyphenylglycine (DHPG) NULL 443586 Quantitative real-time PCR mouse brain 22309833 2012 up-regulated
miR-196a (S)-3,5-dihydroxyphenylglycine (DHPG) NULL 443586 Quantitative real-time PCR mouse brain 22309833 2012 up-regulated
miR-196a 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-196a (S)-3,5-dihydroxyphenylglycine (DHPG) NULL 443586 Quantitative real-time PCR mouse brain 22309833 2012 up-regulated
miR-196a Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-196a-5p (e)-2-methyl-1-[2-(2-methyl-1h-indol-3-yl)indolin-1-yl]but-2-en-1-one 5388204 NSC633484 resistant
hsa-miR-196a-5p (E)-3-[2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl]-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 54613570 NSC750335 sensitive
hsa-miR-196a-5p 1-[4-(5,6-diphenyl-1,2,4-triazin-3-yl)piperazin-1-yl]-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone 54612996 NSC749161 sensitive
hsa-miR-196a-5p 2-[(e)-[6-(4-chloro-3-nitrophenyl)-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl]methylideneamino]guanidine;hydrochloride 16099315 NSC728901 resistant
hsa-miR-196a-5p 2-amino-6-(benzylamino)-4-(2-chlorophenyl)pyridine-3,5-dicarbonitrile 24205132 NSC734396 resistant
hsa-miR-196a-5p 7-[(3,4-dimethoxyphenyl)methyl]-6-phenyl-4,5-dihydropyrrolo[3,4-g][1,2]benzoxazole 60148271 NSC754077 sensitive
hsa-miR-196a-5p Bisarylpurine 45028308 NSC742146 resistant
hsa-miR-196a-5p Camptothecin derivative 97226 NSC107124 sensitive
hsa-miR-196a-5p Dimethylarsinothious acid, 2,4-pyrimidinediyl ester 294741 NSC163664 resistant
hsa-miR-196a-5p Ethyl 5-(2,4-dichlorobenzoyl)oxy-4-oxo-1,3-diphenyl-2-thioxo-thieno[2,3-d]pyrimidine-6-carboxylate 383097 NSC671141 resistant
hsa-miR-196a-5p Gw620972x 766949 NSC756282 sensitive
hsa-miR-196a-5p Methyl 11h-pyrido[2,3-a]carbazole-5-carboxylate 13776879 NSC740203 sensitive
hsa-miR-196a-5p Methyl 6-[2-(diethylamino)ethoxy]-7-[(E)-3-(4-methoxyphenyl)prop-2-enoyl]-3-methyl-1-benzofuran-2-carboxylate;hydrochloride 24204523 NSC732112 resistant
hsa-miR-196a-5p N'-[2-(1,3-benzoxazol-2-ylamino)-6-methylpyrimidin-4-yl]-2-hydroxybenzohydrazide 24205702 NSC736401 resistant
hsa-miR-196a-5p N-(1,3-benzothiazol-2-yl)-2-[4-[(Z)-(3-oxo-1-benzofuran-2-ylidene)methyl]phenoxy]acetamide 45028625 NSC743506 resistant
hsa-miR-196a-5p N,n'-bis[(z)-(2-hydroxyphenyl)methylideneamino]decanediamide 135408549 NSC49488 resistant
hsa-miR-196a-5p NSC617562 NSC617562 resistant
hsa-miR-196a-5p NSC756998 NSC756998 sensitive
hsa-miR-196a-5p Tellurium, trichloro[1,2-hexanedioato(2-)-o,o']-, ammonium 498945 NSC641009 resistant
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3, 2008, OVCAR10, OVCAR3, HeLa, MCF7, MDA-MB-468)
hsa-miR-196a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-196a-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-196a-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (HepG2, Hep-394, Hep-SWX, Huh-7)
hsa-miR-196a-5p Imatinib 5291 NSC743414 approved resistant High Myelogenous Leukemia cell line (MYL)
hsa-miR-196a-5p 10-Hydroxycamptothecin 97226 NSC107124 sensitive High Gastric Cancer cell line (BGC823, SGC-7901, MGC-803, HGC-27, NCI-N87, AGS)
hsa-miR-196a-5p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7, LY2)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-196a-5p Fulvestrant 17756771 NSC719276 approved resistant Low Breast Cancer cell line (MCF-7)
hsa-miR-196a-5p Tamoxifen 2733525 NSC180973 approved resistant Low Breast Cancer cell line (MCF-7)
hsa-miR-196a-5p Doxorubicin 31703 NSC123127 approved resistant High Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-196a-5p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-196a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-196a-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-196a-5p Docetaxel 148124 NSC628503 approved resistant Low Breast Cancer tissue and cell line (MCF-7)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-196a-5p Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-196a-5p Doxorubicin 31703 NSC123127 approved sensitive High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-196a-5p Tamoxifen 2733525 NSC180973 approved sensitive Low Breast Cancer cell line (TAMR1, TAMR4, TAMR8)
hsa-miR-196a-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-196a-5p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-196a-5p Cytoxan + Doxorubicin + Fluorouracil resistant High Breast Cancer tissue
hsa-miR-196a-5p Cytoxan + Epirubicin + Fluorouracil resistant High Breast Cancer tissue
hsa-miR-196a-5p Cytoxan + Pirarubicin + Fluorouracil resistant High Breast Cancer tissue
hsa-miR-196a-5p Doxorubicin + Taxol resistant High Breast Cancer tissue
hsa-miR-196a-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-196a-5p Gefitinib 123631 NSC715055 approved resistant High Non-Small Cell Lung Cancer cell line (PC-9)
hsa-miR-196a-5p Yuanhuadine 6440572 resistant High Non-Small Cell Lung Cancer cell line (PC-9)
hsa-miR-196a-5p Paclitaxel 36314 NSC125973 approved sensitive Low Prostate Cancer cell line (DU-145R)
hsa-miR-196a-5p Paclitaxel + Cisplatin sensitive Low Esophageal Squamous Cell Carcinoma tissue
hsa-miR-196a-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (WM266) (2uM)
hsa-miR-196a-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (WM266) (1uM)
hsa-miR-196a-5p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (WM266) (2uM)
hsa-miR-196a-5p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (WM266) (1uM)
hsa-miR-196a-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-196a-5p Paclitaxel 36314 NSC125973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-196a-5p Trastuzumab resistant High Breast Cancer cell line (MDA‐MB‐231, SKBR3, HEK‐293T)
hsa-miR-196a-5p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CIS)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved resistant High Epithelial Ovarian Cancer cell line (SKOV3)
hsa-miR-196a-5p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-196a-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-196a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-196a-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (total RNA)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-196a-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-196a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-196a-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-196a-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-196a-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-196a-5p Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-196a-5p Testosterone+Exemestane sensitive cell line (MCF-7)
hsa-miR-196a-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-196a-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-196a-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-196a-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR8)
hsa-miR-196a-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (TamR1)
hsa-miR-196a-5p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-196a-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR70)
hsa-miR-196a-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR200)
hsa-miR-196a-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-196a-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-196a-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-196a-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (H460)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (OVCAR3)
hsa-miR-196a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (TOV-112D)

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