miRTarBase - #MIRT032106


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pre-miRNA Information
pre-miRNA hsa-let-7d   
Genomic Coordinates chr9: 94178834 - 94178920
Synonyms LET7D, MIRNLET7D, hsa-let-7d, let-7d, MIRLET7D
Description Homo sapiens let-7d stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-let-7d-5p
Sequence 8| AGAGGUAGUAGGUUGCAUAGUU |29
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 9 + 94178843 27292188 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1462778813 2 dbSNP
rs1467512593 13 dbSNP
rs1329655735 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CALCOCO2   
Synonyms NDP52
Description calcium binding and coiled-coil domain 2
Transcript NM_005831   
Expression
Putative miRNA Targets on CALCOCO2
3'UTR of CALCOCO2
(miRNA target sites are highlighted)		 
>CALCOCO2|NM_005831|3'UTR
   1 GTATCCCAACCTCTTGGATGTATACAGAGATTTTATAGAATAGAACCTATAGCTTCTACCATGAGTTATATGAGTCAAGA
  81 TCCTGCCTAACCTGAAATTATTAGGGATTTACTCAGCCCTGCTGCCGCTAACAGTGGAGTTATGTCACTGATCTGAAGGT
 161 CACTGTTAAGGGCTTCTGCTGCCATCCTTGTGGGTTGCTACCTTTAAGTCGCATAACTCTAGCTGTATCATCCTCTCACC
 241 TGTCATTCTTCTGAGGGTCTCAGTACAAGGGCCCTGGGATGGAGCCAACCTGGGTATTCACAACAGGCCTGACTTGATAC
 321 TAAGTGATTAGTTTTCCAAGTTGTCCCACTGCCATTCAAAGTCAGCCCTTGAGTGTATTTGTTCTCAGTCCTAACCCTGG
 401 GGCCAGAGATTGGTCCGAGGTTGAGAATTCCTTCCTCCTCATCCTTGGTGTTGCTTTCTCCAAATGATTGTTTTAGACTA
 481 GCCAAAAATGCCGTGGCAAAGAGCTCAGAAATCCAATTTGGATACCAAAGGTTTCTCATGTTAATTTCTCAGCCCCCAAA
 561 GAAGCATCTTACTCCTGAACCTTAGACAGGAAGTATTGTTTCAGTCACAGAAAGCTTTTCTGGGTACCTCTGGTTAGCAC
 641 TTTCTACTCTCTGATATTTCCTATGTACATAGCTTTTATTGTTGTAAATCCTTTCTTAATGGTTAAATAGGATTGTTAGC
 721 AACTATGGGTTTGCAGTTTTCTGAGTAGGTGAGTTTTGAATATGGGTAAATCAGAATAATGAGACAACTTGTTAATCTCT
 801 TTAATACTAAAAATAAATTACTCTTCTATTTCAGGGACTTAGGTAATTTAAAATAAACCTTCAATTTATGGTCTTCTGTT
 881 TTGAAGCTCATGGGAAAATTGTGATCAAAAGGGCTATGGGAAGGGCAGACCCCGCCAATGATTTCTCTTCACCTGTCTTA
 961 AGATTAAATAAAAAAGAGTGTCCTGGCAGTTATCTTGAGGTGGGGAAGGAGGTGATGAAACATTAGTTTGTGAAATCCAA
1041 GGCCCTGGCTTGCTTTCTTTCTTTTTTTTTTTTTTTTTTTGAAACAGTCTCTCTCTGTCACCCAGGCTGGCGTGCAATGG
1121 CGCAGTTGACTCACTACAGCCTCTGCCTCCCAGGTTCAAGCGATTCTCATGCCTTAGCCTCCCAAGTAGCTGGGATTACA
1201 GGTGTGTGCCGCAATGCCCAGCTAATTTTTGTGTTTTTAGTAGAGACAGGGTTTCACTATGTTGGCCAGGCTGGTCTCGA
1281 ACTCCTGGCCTCACGTGATCTGTCCACTTCAGCCGTCCAAAGTGCTGGGATTACAAGCGTGAGCCACTGTGCTGGGCCCG
1361 AGGCCCTGACTTCTTGCTGTAACTTTCCATGCATTTTTTTTAAAAGGAGCAGTGTGGATTTTCGCACCCTTTGTGAACTA
1441 AGTTCAATGCGCTCTATCCAAATTTGCCTAATTGAACTATAAGAAAGTAATAATTCCATTTTCTATCCCCTCAGGGACTG
1521 AACAAATGGAAATAACTCCCAGGCAGTATCAGGTGGTCACTACAGAGACTTCCACAAAAACTTTTGAATGATGTGAAACA
1601 CGATGTCATGAATAAGGGTTGAGCCAACTATAGCTCTGTGTTCCTACTGGGCTTTCCCTAATGTGGTTGGGAGTTATGCC
1681 CTAGACTAACTGTATTGTCCTAGTCACAGCTCCTTGCTTTGATTTCATCCTTGATAAAATGAAGATGAAACTTACACTAC
1761 TTCTCCAAGCCTTTTGCTGTCTTAAGAATAAGACCTGAGATTAACACTAACCCTAGAATAGAAATGTAATAGGGAGATGG
1841 TAATAAAGGAGTTTTTCTGGCACATACCCTCCCTACAGAATTTCTGTTGCTCCCCAGATCCAGTGAAGAATTGCAGTTTC
1921 ATTTATTTTGTACCAGTCAGCTCTTAATTAAGTACATGAATGGAGAGGAACAGTGGTGCACATAATCCAAATCAGTGAAT
2001 ACCATTTTCTGGTGAATTACCCACCCCTTTGCCCCTGCTACCCCGAGGGTTACCATGATTGTCAACAGCAGCAGGAGCCC
2081 TTCCACAGGGCTTGGTAAAAAAACCAGTTGAGGTGTTAATGACCCTTTTTGCTGGGTGTAAAACAAAGCATCTTTAACCA
2161 CTGTTCATTATCCCCAGCTGCTCTTACCAAGGCTTTGAAGGGGGAAATTATGCTCTAGGCAGCCACTAGTAGTAAACAAT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uugaUACGUUGGA--UGAUGGAGa 5'
              ||| |||:|  |||||:|| 
Target 5' gaagATGAAACTTACACTACTTCt 3'
 1741 - 1764 152.00 -14.30
2 
miRNA  3' uuGAUACGUUGGAUGAUGGAGa 5'
            |||  ||:||| ||:|||| 
Target 5' caCTA--CAGCCT-CTGCCTCc 3'
 1132 - 1150 147.00 -19.50
3 
miRNA  3' uuGAUACGUUGGAUGAUGGAGa 5'
            || ||::: :|:||||||: 
Target 5' tcCT-TGTGGGTTGCTACCTTt 3'
 185 - 205 143.00 -15.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26969031 2 COSMIC
COSN26969030 39 COSMIC
COSN507377 82 COSMIC
COSN1720837 155 COSMIC
COSN30141176 186 COSMIC
COSN20618412 818 COSMIC
COSN22426304 998 COSMIC
COSN20093308 1058 COSMIC
COSN20093310 1062 COSMIC
COSN5840532 1331 COSMIC
COSN30668363 1337 COSMIC
COSN30637877 1340 COSMIC
COSN20072265 1402 COSMIC
COSN30724145 1402 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs748873558 7 dbSNP
rs370021564 10 dbSNP
rs1324252241 11 dbSNP
rs773686834 12 dbSNP
rs1434565902 18 dbSNP
rs747585518 21 dbSNP
rs1379174229 26 dbSNP
rs760246354 26 dbSNP
rs368965437 29 dbSNP
rs955495651 35 dbSNP
rs777106523 37 dbSNP
rs770204009 39 dbSNP
rs987088562 40 dbSNP
rs367617158 42 dbSNP
rs763207480 44 dbSNP
rs369461455 47 dbSNP
rs3744605 50 dbSNP
rs763598403 52 dbSNP
rs767334646 54 dbSNP
rs750286398 57 dbSNP
rs755908643 60 dbSNP
rs779768956 61 dbSNP
rs974477900 62 dbSNP
rs767552503 66 dbSNP
rs920035622 71 dbSNP
rs753513090 75 dbSNP
rs754548944 79 dbSNP
rs551249541 93 dbSNP
rs142936561 103 dbSNP
rs1010179578 105 dbSNP
rs749298977 114 dbSNP
rs758380990 116 dbSNP
rs1287153684 119 dbSNP
rs1360959305 127 dbSNP
rs1055106950 128 dbSNP
rs968555196 133 dbSNP
rs917770579 140 dbSNP
rs1318993687 156 dbSNP
rs1246174183 159 dbSNP
rs1321733522 165 dbSNP
rs1294618619 166 dbSNP
rs949200318 183 dbSNP
rs1286990826 185 dbSNP
rs551604431 190 dbSNP
rs985265634 203 dbSNP
rs1388481559 208 dbSNP
rs1361195476 211 dbSNP
rs902418916 212 dbSNP
rs1000574443 213 dbSNP
rs1420065727 231 dbSNP
rs1053430476 233 dbSNP
rs111623438 234 dbSNP
rs1343462995 239 dbSNP
rs995939527 240 dbSNP
rs182181766 258 dbSNP
rs1264248625 259 dbSNP
rs1195779496 262 dbSNP
rs1450169777 262 dbSNP
rs534791657 263 dbSNP
rs965452566 264 dbSNP
rs1210905395 266 dbSNP
rs1222491760 269 dbSNP
rs535828910 274 dbSNP
rs1278977679 276 dbSNP
rs977212382 282 dbSNP
rs918623827 289 dbSNP
rs555768599 292 dbSNP
rs1216307524 295 dbSNP
rs1316907712 298 dbSNP
rs1278516664 331 dbSNP
rs1229161267 338 dbSNP
rs1213040927 341 dbSNP
rs1329091095 345 dbSNP
rs1260607344 352 dbSNP
rs1030061427 359 dbSNP
rs929948115 364 dbSNP
rs1396662520 368 dbSNP
rs1329385168 375 dbSNP
rs1488916566 376 dbSNP
rs1424437046 381 dbSNP
rs984425059 402 dbSNP
rs1477173857 403 dbSNP
rs1267168621 404 dbSNP
rs1200068343 405 dbSNP
rs1470201137 416 dbSNP
rs1480350677 417 dbSNP
rs955574687 418 dbSNP
rs1008804038 420 dbSNP
rs186046835 422 dbSNP
rs961913100 432 dbSNP
rs367938946 436 dbSNP
rs1342491748 437 dbSNP
rs1274006921 440 dbSNP
rs974131954 446 dbSNP
rs1398959333 448 dbSNP
rs566366066 455 dbSNP
rs558844842 456 dbSNP
rs1373096226 459 dbSNP
rs990869225 479 dbSNP
rs1045276826 490 dbSNP
rs1445975524 493 dbSNP
rs572604711 494 dbSNP
rs1331009439 499 dbSNP
rs917963788 509 dbSNP
rs1300007542 517 dbSNP
rs1412948031 526 dbSNP
rs190271998 550 dbSNP
rs113174988 558 dbSNP
rs1057267468 560 dbSNP
rs771280775 565 dbSNP
rs891501415 573 dbSNP
rs1010308197 578 dbSNP
rs1440883372 584 dbSNP
rs1232923767 588 dbSNP
rs182496718 596 dbSNP
rs1440324114 598 dbSNP
rs866070146 604 dbSNP
rs1404123270 608 dbSNP
rs978325845 614 dbSNP
rs777093345 616 dbSNP
rs185391645 629 dbSNP
rs904449965 635 dbSNP
rs1239284537 643 dbSNP
rs1006736989 644 dbSNP
rs1305640376 645 dbSNP
rs1281326936 647 dbSNP
rs1353843017 651 dbSNP
rs1018076271 661 dbSNP
rs191171829 662 dbSNP
rs1053673325 664 dbSNP
rs900187023 665 dbSNP
rs1358968995 670 dbSNP
rs965169481 679 dbSNP
rs867685277 705 dbSNP
rs1420821117 707 dbSNP
rs931598024 712 dbSNP
rs1178428531 736 dbSNP
rs568460420 742 dbSNP
rs1248635158 750 dbSNP
rs182495082 754 dbSNP
rs1051546117 755 dbSNP
rs1468822327 761 dbSNP
rs1176889381 764 dbSNP
rs1380962798 775 dbSNP
rs34091460 783 dbSNP
rs1441697119 784 dbSNP
rs1160370468 789 dbSNP
rs1215687347 800 dbSNP
rs146106997 802 dbSNP
rs1286339063 804 dbSNP
rs1226540017 819 dbSNP
rs1355659085 822 dbSNP
rs545289073 824 dbSNP
rs535850856 833 dbSNP
rs1338780917 836 dbSNP
rs984531127 838 dbSNP
rs1401064149 859 dbSNP
rs1347325434 875 dbSNP
rs11434 879 dbSNP
rs775828489 883 dbSNP
rs948299811 890 dbSNP
rs995735404 891 dbSNP
rs1165058117 892 dbSNP
rs1475968723 904 dbSNP
rs1027156481 905 dbSNP
rs959371254 906 dbSNP
rs1323991707 914 dbSNP
rs376569257 917 dbSNP
rs1192657704 921 dbSNP
rs1351454497 926 dbSNP
rs1486032977 927 dbSNP
rs1253253681 931 dbSNP
rs189256497 934 dbSNP
rs1025095373 935 dbSNP
rs547222720 939 dbSNP
rs939513637 950 dbSNP
rs977978482 954 dbSNP
rs923784650 958 dbSNP
rs560628021 965 dbSNP
rs1297315944 971 dbSNP
rs1364467291 979 dbSNP
rs1376972832 988 dbSNP
rs936494394 989 dbSNP
rs891545835 994 dbSNP
rs140074280 1005 dbSNP
rs1395910100 1008 dbSNP
rs149773748 1016 dbSNP
rs1325977719 1022 dbSNP
rs1462621190 1025 dbSNP
rs921838268 1026 dbSNP
rs1359397999 1027 dbSNP
rs1421337841 1029 dbSNP
rs1189303910 1030 dbSNP
rs931675041 1040 dbSNP
rs1253622066 1041 dbSNP
rs1215493892 1048 dbSNP
rs1229203110 1048 dbSNP
rs1051409559 1049 dbSNP
rs6504584 1053 dbSNP
rs199578721 1054 dbSNP
rs538918273 1057 dbSNP
rs1219064515 1058 dbSNP
rs1372355467 1058 dbSNP
rs1204088488 1059 dbSNP
rs1445230560 1060 dbSNP
rs1177907454 1062 dbSNP
rs1209683222 1062 dbSNP
rs1237612233 1062 dbSNP
rs1254552619 1062 dbSNP
rs1437786622 1062 dbSNP
rs1457619489 1062 dbSNP
rs35356632 1062 dbSNP
rs982274977 1062 dbSNP
rs1239081945 1064 dbSNP
rs549706411 1065 dbSNP
rs1181856192 1066 dbSNP
rs1238560134 1066 dbSNP
rs552833066 1067 dbSNP
rs904168201 1067 dbSNP
rs1383249199 1068 dbSNP
rs1006790991 1070 dbSNP
rs1300657003 1071 dbSNP
rs1433740996 1074 dbSNP
rs1375798228 1080 dbSNP
rs1175330274 1081 dbSNP
rs1035857596 1082 dbSNP
rs1415687006 1084 dbSNP
rs1408054578 1086 dbSNP
rs1159913857 1088 dbSNP
rs1363210781 1088 dbSNP
rs1169441639 1097 dbSNP
rs566286206 1107 dbSNP
rs940447270 1112 dbSNP
rs1448303378 1113 dbSNP
rs1260011010 1122 dbSNP
rs193089215 1123 dbSNP
rs1353616324 1129 dbSNP
rs1339420233 1134 dbSNP
rs1241826885 1141 dbSNP
rs1449359393 1147 dbSNP
rs901051607 1150 dbSNP
rs1286535024 1152 dbSNP
rs1309998275 1153 dbSNP
rs1413758764 1154 dbSNP
rs763580909 1162 dbSNP
rs182916966 1163 dbSNP
rs1397981249 1165 dbSNP
rs1027230170 1175 dbSNP
rs765456779 1177 dbSNP
rs187215929 1181 dbSNP
rs1025384077 1187 dbSNP
rs537548143 1191 dbSNP
rs568407470 1194 dbSNP
rs750187158 1203 dbSNP
rs1164353561 1205 dbSNP
rs1443139327 1207 dbSNP
rs1420380174 1208 dbSNP
rs1191784653 1211 dbSNP
rs7216848 1212 dbSNP
rs1262896628 1217 dbSNP
rs1207371245 1219 dbSNP
rs545917016 1224 dbSNP
rs1239144284 1225 dbSNP
rs1474264121 1232 dbSNP
rs1263146160 1234 dbSNP
rs969362224 1235 dbSNP
rs1335065141 1236 dbSNP
rs766240452 1254 dbSNP
rs1294671322 1260 dbSNP
rs1031046089 1266 dbSNP
rs1196234126 1268 dbSNP
rs957866098 1270 dbSNP
rs1318760277 1273 dbSNP
rs1383817019 1279 dbSNP
rs755277942 1280 dbSNP
rs1325286524 1285 dbSNP
rs921869219 1288 dbSNP
rs953262002 1295 dbSNP
rs565170456 1296 dbSNP
rs191776532 1315 dbSNP
rs7217035 1316 dbSNP
rs1195845987 1320 dbSNP
rs940328471 1321 dbSNP
rs1036527078 1329 dbSNP
rs752831561 1330 dbSNP
rs1399729398 1339 dbSNP
rs931522603 1340 dbSNP
rs1279207140 1348 dbSNP
rs1048528619 1351 dbSNP
rs1221906884 1352 dbSNP
rs1196320150 1360 dbSNP
rs144652100 1361 dbSNP
rs560764610 1367 dbSNP
rs1345736574 1371 dbSNP
rs1046621437 1382 dbSNP
rs1329141045 1387 dbSNP
rs777929610 1390 dbSNP
rs1039311600 1392 dbSNP
rs1202250882 1394 dbSNP
rs901088948 1394 dbSNP
rs998089731 1402 dbSNP
rs1397558539 1403 dbSNP
rs1170007468 1410 dbSNP
rs1445235321 1412 dbSNP
rs1464795608 1413 dbSNP
rs529701801 1414 dbSNP
rs999499432 1417 dbSNP
rs1047352344 1418 dbSNP
rs1031543083 1424 dbSNP
rs886935503 1425 dbSNP
rs1192919533 1427 dbSNP
rs1436849026 1430 dbSNP
rs573028323 1431 dbSNP
rs1197197558 1440 dbSNP
rs1345411241 1445 dbSNP
rs1006076181 1446 dbSNP
rs1234894914 1448 dbSNP
rs7222365 1451 dbSNP
rs183862864 1452 dbSNP
rs1441657638 1462 dbSNP
rs1336436575 1477 dbSNP
rs189500022 1478 dbSNP
rs558100219 1487 dbSNP
rs1173840309 1488 dbSNP
rs781540416 1491 dbSNP
rs746140367 1514 dbSNP
rs770049226 1515 dbSNP
rs868407855 1518 dbSNP
rs988379601 1524 dbSNP
rs914084139 1527 dbSNP
rs573141012 1530 dbSNP
rs117327540 1537 dbSNP
rs555637449 1543 dbSNP
rs962046862 1546 dbSNP
rs1484509561 1550 dbSNP
rs1256517376 1553 dbSNP
rs1211408082 1558 dbSNP
rs1403505055 1563 dbSNP
rs925696569 1571 dbSNP
rs867434227 1578 dbSNP
rs1281987126 1579 dbSNP
rs117542323 1596 dbSNP
rs769157072 1602 dbSNP
rs568670928 1603 dbSNP
rs773812343 1610 dbSNP
rs1281378391 1613 dbSNP
rs1331930182 1619 dbSNP
rs1355115373 1632 dbSNP
rs1313855536 1638 dbSNP
rs1417081531 1639 dbSNP
rs920371029 1642 dbSNP
rs942415301 1644 dbSNP
rs1039363963 1662 dbSNP
rs1277833112 1668 dbSNP
rs1401827295 1672 dbSNP
rs930384482 1681 dbSNP
rs1055442550 1685 dbSNP
rs761336543 1686 dbSNP
rs1353128853 1695 dbSNP
rs916767644 1704 dbSNP
rs574038848 1709 dbSNP
rs948185492 1714 dbSNP
rs1159843607 1718 dbSNP
rs1408032365 1718 dbSNP
rs1474012451 1729 dbSNP
rs527246147 1730 dbSNP
rs922264230 1733 dbSNP
rs1486494449 1744 dbSNP
rs1489117836 1748 dbSNP
rs1240169078 1753 dbSNP
rs544362445 1754 dbSNP
rs1447556279 1767 dbSNP
rs1286407552 1769 dbSNP
rs1211965974 1771 dbSNP
rs1334438681 1776 dbSNP
rs748873609 1780 dbSNP
rs1046958762 1782 dbSNP
rs1235394856 1783 dbSNP
rs768370706 1784 dbSNP
rs1266182078 1800 dbSNP
rs116941442 1808 dbSNP
rs1052433759 1820 dbSNP
rs1361552530 1825 dbSNP
rs1038177180 1831 dbSNP
rs905279021 1847 dbSNP
rs1438602162 1850 dbSNP
rs1165141547 1851 dbSNP
rs893782362 1857 dbSNP
rs1476003704 1863 dbSNP
rs1011012540 1865 dbSNP
rs1417093948 1866 dbSNP
rs73989228 1870 dbSNP
rs1035441801 1872 dbSNP
rs953197502 1874 dbSNP
rs766078085 1885 dbSNP
rs1019316414 1887 dbSNP
rs896470816 1895 dbSNP
rs1306031260 1898 dbSNP
rs1272722584 1900 dbSNP
rs1215590065 1901 dbSNP
rs1364525924 1906 dbSNP
rs1301800042 1909 dbSNP
rs1440845808 1913 dbSNP
rs961972395 1914 dbSNP
rs1021203937 1915 dbSNP
rs753667536 1928 dbSNP
rs1169483669 1937 dbSNP
rs1391967402 1939 dbSNP
rs1191626432 1944 dbSNP
rs1421407690 1944 dbSNP
rs1388712247 1948 dbSNP
rs759503547 1949 dbSNP
rs979574094 1957 dbSNP
rs1327182471 1981 dbSNP
rs1253678982 1986 dbSNP
rs1027292143 1987 dbSNP
rs1195638132 1988 dbSNP
rs1017705327 1989 dbSNP
rs1232447605 1990 dbSNP
rs1205501935 1998 dbSNP
rs1240987577 2010 dbSNP
rs765286246 2021 dbSNP
rs1309577753 2027 dbSNP
rs1278681704 2043 dbSNP
rs539798015 2045 dbSNP
rs975120129 2046 dbSNP
rs922286841 2047 dbSNP
rs553113613 2048 dbSNP
rs991202870 2054 dbSNP
rs1297187705 2055 dbSNP
rs915628027 2063 dbSNP
rs1372144851 2066 dbSNP
rs948255031 2067 dbSNP
rs1434011487 2074 dbSNP
rs1356866082 2076 dbSNP
rs933672012 2084 dbSNP
rs1417333366 2097 dbSNP
rs983140414 2097 dbSNP
rs982284569 2098 dbSNP
rs1249934782 2099 dbSNP
rs908465829 2105 dbSNP
rs1255826977 2123 dbSNP
rs928234189 2125 dbSNP
rs35377200 2126 dbSNP
rs547296820 2126 dbSNP
rs1456880973 2136 dbSNP
rs1038227549 2149 dbSNP
rs904995553 2151 dbSNP
rs935608887 2154 dbSNP
rs1056533044 2173 dbSNP
rs1223970187 2175 dbSNP
rs752729899 2177 dbSNP
rs571975876 2203 dbSNP
rs540936522 2207 dbSNP
rs1310839303 2208 dbSNP
rs1413865806 2214 dbSNP
rs1375847421 2218 dbSNP
rs893813339 2223 dbSNP
rs946664089 2240 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KICH -0.66 0 -0.564 0 25 Click to see details
LIHC -0.355 0.01 -0.368 0 49 Click to see details
PAAD 0.929 0.04 0.800 0.1 4 Click to see details
CHOL 0.614 0.04 0.683 0.02 9 Click to see details
PRAD -0.227 0.06 -0.232 0.05 50 Click to see details
LUSC -0.229 0.08 -0.215 0.1 38 Click to see details
HNSC 0.2 0.1 0.161 0.15 42 Click to see details
STAD -0.216 0.12 -0.242 0.09 32 Click to see details
BLCA 0.259 0.15 0.084 0.37 18 Click to see details
UCEC -0.236 0.17 -0.360 0.07 19 Click to see details
PCPG 0.824 0.19 0.500 0.33 3 Click to see details
ESCA -0.277 0.2 -0.173 0.31 11 Click to see details
LUAD 0.221 0.25 0.385 0.11 12 Click to see details
CESC -0.608 0.29 -0.500 0.33 3 Click to see details
KIRC -0.041 0.37 -0.020 0.44 68 Click to see details
BRCA 0.027 0.4 0.026 0.41 84 Click to see details
KIRP 0.024 0.45 0.049 0.39 32 Click to see details
COAD -0.052 0.45 -0.214 0.31 8 Click to see details
THCA -0.004 0.49 -0.008 0.48 59 Click to see details
THCA -0.004 0.49 -0.008 0.48 59 Click to see details
THCA -0.004 0.49 -0.008 0.48 59 Click to see details
370 hsa-let-7d-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000401 BDNF brain derived neurotrophic factor 1 1
MIRT000402 CDK6 cyclin dependent kinase 6 1 1
MIRT000403 CDC25A cell division cycle 25A 1 1
MIRT000405 BCL2 BCL2, apoptosis regulator 1 1
MIRT000406 KRAS KRAS proto-oncogene, GTPase 1 1
MIRT002005 HMGA2 high mobility group AT-hook 2 6 8
MIRT003901 APP amyloid beta precursor protein 2 1
MIRT004347 DICER1 dicer 1, ribonuclease III 3 1
MIRT004505 SLC11A2 solute carrier family 11 member 2 6 5
MIRT005549 PDGFA platelet derived growth factor subunit A 3 1
MIRT006398 IL13 interleukin 13 2 1
MIRT006406 MPL MPL proto-oncogene, thrombopoietin receptor 1 1
MIRT032101 RABGAP1L RAB GTPase activating protein 1 like 1 1
MIRT032102 DRD3 dopamine receptor D3 1 1
MIRT032103 SMOX spermine oxidase 1 1
MIRT032104 DAD1 defender against cell death 1 1 1
MIRT032105 EIF4G2 eukaryotic translation initiation factor 4 gamma 2 3 5
MIRT032106 CALCOCO2 calcium binding and coiled-coil domain 2 1 1
MIRT032107 GPR63 G protein-coupled receptor 63 1 1
MIRT032108 FAM135A family with sequence similarity 135 member A 1 1
MIRT032109 CPNE1 copine 1 1 1
MIRT032110 NR4A1 nuclear receptor subfamily 4 group A member 1 1 1
MIRT032111 BUB3 BUB3, mitotic checkpoint protein 1 1
MIRT032112 TBC1D9B TBC1 domain family member 9B 1 1
MIRT032113 LARP4B La ribonucleoprotein domain family member 4B 1 1
MIRT032114 NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit 2 3
MIRT032115 FBXO3 F-box protein 3 1 1
MIRT032116 ZNF763 zinc finger protein 763 1 1
MIRT032117 PCNP PEST proteolytic signal containing nuclear protein 1 1
MIRT032118 HOMER1 homer scaffolding protein 1 1 1
MIRT032119 RBM12 RNA binding motif protein 12 1 1
MIRT032120 KMT2A lysine methyltransferase 2A 1 1
MIRT032121 CBR4 carbonyl reductase 4 1 1
MIRT032122 THBS1 thrombospondin 1 2 4
MIRT032123 TLE4 transducin like enhancer of split 4 1 1
MIRT032124 TOMM20 translocase of outer mitochondrial membrane 20 1 1
MIRT032125 TMED4 transmembrane p24 trafficking protein 4 1 1
MIRT032126 AKAP8 A-kinase anchoring protein 8 2 4
MIRT032127 TST thiosulfate sulfurtransferase 1 1
MIRT032128 GPR137B G protein-coupled receptor 137B 1 1
MIRT032129 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 1 1
MIRT032130 IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 2 4
MIRT032131 RPUSD2 RNA pseudouridylate synthase domain containing 2 1 1
MIRT032132 ZBTB24 zinc finger and BTB domain containing 24 1 1
MIRT032133 SPATA2 spermatogenesis associated 2 1 1
MIRT032134 GOLT1B golgi transport 1B 1 1
MIRT032135 ERC1 ELKS/RAB6-interacting/CAST family member 1 1 1
MIRT032136 SREK1IP1 SREK1 interacting protein 1 1 1
MIRT032137 RFX5 regulatory factor X5 1 1
MIRT032138 BIN3 bridging integrator 3 1 1
MIRT032139 CEP120 centrosomal protein 120 2 3
MIRT032140 ZNF526 zinc finger protein 526 1 1
MIRT032141 ISL1 ISL LIM homeobox 1 1 1
MIRT032142 POLR2D RNA polymerase II subunit D 2 5
MIRT032143 SMCR7L mitochondrial elongation factor 1 1 4
MIRT032144 TMEM194A nuclear envelope integral membrane protein 1 1 1
MIRT032145 KATNAL1 katanin catalytic subunit A1 like 1 1 1
MIRT032146 C12orf4 chromosome 12 open reading frame 4 2 3
MIRT032147 TMEM2 transmembrane protein 2 1 1
MIRT032148 DLC1 DLC1 Rho GTPase activating protein 1 1
MIRT032149 TMTC3 transmembrane and tetratricopeptide repeat containing 3 2 3
MIRT032150 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 1 1
MIRT032151 ZNF354B zinc finger protein 354B 1 1
MIRT032152 ZNF200 zinc finger protein 200 2 4
MIRT032153 ADCY9 adenylate cyclase 9 1 1
MIRT032154 TNRC6A trinucleotide repeat containing 6A 1 1
MIRT032155 STK40 serine/threonine kinase 40 1 1
MIRT032156 PCGF3 polycomb group ring finger 3 2 6
MIRT032157 ZBTB39 zinc finger and BTB domain containing 39 1 1
MIRT032158 LIN52 lin-52 DREAM MuvB core complex component 1 1
MIRT032159 RAD9A RAD9 checkpoint clamp component A 1 1
MIRT032160 ARRDC4 arrestin domain containing 4 1 1
MIRT032161 SLC30A6 solute carrier family 30 member 6 1 1
MIRT032162 LBR lamin B receptor 1 1
MIRT032163 C9orf41 carnosine N-methyltransferase 1 1 1
MIRT032164 ESPL1 extra spindle pole bodies like 1, separase 2 5
MIRT032165 ABT1 activator of basal transcription 1 2 9
MIRT032166 NHLRC3 NHL repeat containing 3 2 6
MIRT032167 GLMN glomulin, FKBP associated protein 1 1
MIRT032168 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT032169 ZNF644 zinc finger protein 644 2 3
MIRT032170 C11orf57 chromosome 11 open reading frame 57 2 5
MIRT032171 FAM104A family with sequence similarity 104 member A 2 2
MIRT032172 SPRYD4 SPRY domain containing 4 1 1
MIRT032173 ARID3A AT-rich interaction domain 3A 2 3
MIRT032174 SLC10A7 solute carrier family 10 member 7 2 6
MIRT032175 ONECUT2 one cut homeobox 2 2 3
MIRT032176 USP24 ubiquitin specific peptidase 24 1 1
MIRT032177 SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 2 4
MIRT032178 TGFBR1 transforming growth factor beta receptor 1 1 1
MIRT032179 HAND1 heart and neural crest derivatives expressed 1 2 3
MIRT032180 KPNA5 karyopherin subunit alpha 5 2 8
MIRT032181 IGF1R insulin like growth factor 1 receptor 2 9
MIRT032182 TMEM135 transmembrane protein 135 1 1
MIRT032183 SLC20A1 solute carrier family 20 member 1 2 4
MIRT032184 ZNF280B zinc finger protein 280B 1 1
MIRT032185 LIN28B lin-28 homolog B 1 1
MIRT032186 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 3
MIRT051710 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 1 1
MIRT051711 PRR13 proline rich 13 1 1
MIRT051712 ZNF746 zinc finger protein 746 1 1
MIRT051713 SLC35A4 solute carrier family 35 member A4 1 1
MIRT051714 RPL31 ribosomal protein L31 1 1
MIRT051715 TPD52L2 tumor protein D52 like 2 1 1
MIRT051716 MRPL51 mitochondrial ribosomal protein L51 1 1
MIRT051717 CTDP1 CTD phosphatase subunit 1 1 1
MIRT051718 RPS6 ribosomal protein S6 1 1
MIRT051719 SENP5 SUMO1/sentrin specific peptidase 5 1 1
MIRT051720 PAXBP1 PAX3 and PAX7 binding protein 1 1 1
MIRT051721 DHX57 DExH-box helicase 57 1 1
MIRT051722 H2AFX H2A histone family member X 1 1
MIRT051723 DSC3 desmocollin 3 1 1
MIRT051724 CIZ1 CDKN1A interacting zinc finger protein 1 1 1
MIRT051725 NCOA1 nuclear receptor coactivator 1 1 1
MIRT051726 LRRC42 leucine rich repeat containing 42 1 1
MIRT051727 UTP6 UTP6, small subunit processome component 1 1
MIRT063194 ADIPOR2 adiponectin receptor 2 2 2
MIRT068153 TXLNA taxilin alpha 2 2
MIRT068788 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT073005 ARID3B AT-rich interaction domain 3B 2 6
MIRT076222 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 6
MIRT083299 ZCCHC3 zinc finger CCHC-type containing 3 2 2
MIRT084975 BACH1 BTB domain and CNC homolog 1 4 3
MIRT095765 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT112241 MDM4 MDM4, p53 regulator 2 4
MIRT118585 STK4 serine/threonine kinase 4 2 2
MIRT120920 PDE12 phosphodiesterase 12 2 8
MIRT123316 CALU calumenin 2 2
MIRT123975 POLR3D RNA polymerase III subunit D 2 2
MIRT152271 TNFSF9 TNF superfamily member 9 2 2
MIRT153846 NCOA3 nuclear receptor coactivator 3 2 2
MIRT168582 HMGA1 high mobility group AT-hook 1 2 4
MIRT180602 CRY2 cryptochrome circadian clock 2 2 2
MIRT187716 SUOX sulfite oxidase 2 2
MIRT191403 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT193100 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT215719 C5ORF51 chromosome 5 open reading frame 51 2 10
MIRT218814 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT240329 UBXN2B UBX domain protein 2B 2 2
MIRT243472 TRIM71 tripartite motif containing 71 2 2
MIRT244068 EDN1 endothelin 1 2 2
MIRT252329 SALL3 spalt like transcription factor 3 2 2
MIRT255313 CDV3 CDV3 homolog 2 2
MIRT259276 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT259478 TXLNG taxilin gamma 2 2
MIRT260706 CLDN12 claudin 12 2 6
MIRT266211 PEX11B peroxisomal biogenesis factor 11 beta 2 2
MIRT266625 CHTOP chromatin target of PRMT1 2 2
MIRT268838 C1ORF21 chromosome 1 open reading frame 21 2 2
MIRT284527 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT294445 ZNF264 zinc finger protein 264 2 2
MIRT297012 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT300036 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT300892 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT303319 MXD1 MAX dimerization protein 1 2 2
MIRT309845 NAT8L N-acetyltransferase 8 like 2 2
MIRT322427 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT324730 ACER2 alkaline ceramidase 2 2 2
MIRT402056 ATP6V1F ATPase H+ transporting V1 subunit F 2 4
MIRT437855 EIF2C1 argonaute 1, RISC catalytic component 3 1
MIRT438633 TNFRSF10B TNF receptor superfamily member 10b 2 1
MIRT439136 ZEB2 zinc finger E-box binding homeobox 2 0 1
MIRT439137 MYC MYC proto-oncogene, bHLH transcription factor 0 1
MIRT442021 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT445659 ATP6V1G1 ATPase H+ transporting V1 subunit G1 2 6
MIRT447137 KIF27 kinesin family member 27 2 2
MIRT448263 ZNF774 zinc finger protein 774 2 2
MIRT449006 ANKRD46 ankyrin repeat domain 46 2 2
MIRT449954 FMNL3 formin like 3 2 2
MIRT451156 C19orf53 chromosome 19 open reading frame 53 2 2
MIRT451625 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT451694 C1RL complement C1r subcomponent like 2 2
MIRT452093 NUCB2 nucleobindin 2 2 2
MIRT452432 QDPR quinoid dihydropteridine reductase 2 2
MIRT452944 DISC1 disrupted in schizophrenia 1 2 2
MIRT453402 RHD Rh blood group D antigen 2 6
MIRT454165 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT454281 FXN frataxin 2 2
MIRT454540 RABL2A RAB, member of RAS oncogene family like 2A 2 2
MIRT454855 ACOT9 acyl-CoA thioesterase 9 2 4
MIRT455677 GLO1 glyoxalase I 2 2
MIRT457249 RABL2B RAB, member of RAS oncogene family like 2B 2 2
MIRT457678 ZNF587 zinc finger protein 587 2 2
MIRT457888 THEM6 thioesterase superfamily member 6 2 4
MIRT458017 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT458280 FUT10 fucosyltransferase 10 2 2
MIRT459737 RRM1 ribonucleotide reductase catalytic subunit M1 2 2
MIRT460454 NOM1 nucleolar protein with MIF4G domain 1 2 4
MIRT460501 FAM105A family with sequence similarity 105 member A 2 6
MIRT460939 NOA1 nitric oxide associated 1 2 4
MIRT461093 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT461365 COL8A1 collagen type VIII alpha 1 chain 2 2
MIRT462383 YAE1D1 Yae1 domain containing 1 2 2
MIRT462781 ZNF8 zinc finger protein 8 2 2
MIRT463418 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463663 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT464266 VCL vinculin 2 2
MIRT465125 TSC22D2 TSC22 domain family member 2 2 4
MIRT466186 TMED5 transmembrane p24 trafficking protein 5 2 4
MIRT466720 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT469103 RNF144B ring finger protein 144B 2 2
MIRT469713 RAB40C RAB40C, member RAS oncogene family 2 2
MIRT470424 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 2
MIRT470860 PLXND1 plexin D1 2 2
MIRT471270 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT471965 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT472738 MTUS1 microtubule associated scaffold protein 1 2 6
MIRT473135 MLLT10 MLLT10, histone lysine methyltransferase DOT1L cofactor 2 2
MIRT473829 MAP2K7 mitogen-activated protein kinase kinase 7 2 2
MIRT473941 LYN LYN proto-oncogene, Src family tyrosine kinase 2 2
MIRT474024 LRRC20 leucine rich repeat containing 20 2 2
MIRT474501 KLHDC8B kelch domain containing 8B 2 2
MIRT474760 KIAA0930 KIAA0930 2 2
MIRT474908 KCTD21 potassium channel tetramerization domain containing 21 2 2
MIRT475332 IFNLR1 interferon lambda receptor 1 2 2
MIRT475380 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT475734 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT476549 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT476974 FAM83G family with sequence similarity 83 member G 2 4
MIRT477679 EFHD2 EF-hand domain family member D2 2 2
MIRT479750 CCND1 cyclin D1 2 2
MIRT481194 ATXN7L3B ataxin 7 like 3B 2 4
MIRT481239 ATXN7L3 ataxin 7 like 3 2 2
MIRT481364 ATG9A autophagy related 9A 2 2
MIRT481389 ATG12 autophagy related 12 2 2
MIRT481653 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT481853 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT482185 AHR aryl hydrocarbon receptor 2 2
MIRT482221 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT485297 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT486660 ZNF28 zinc finger protein 28 2 2
MIRT489414 TUBB2A tubulin beta 2A class IIa 2 2
MIRT491865 ZBTB5 zinc finger and BTB domain containing 5 2 8
MIRT492211 SOCS1 suppressor of cytokine signaling 1 2 2
MIRT492625 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT493322 LIMD2 LIM domain containing 2 2 2
MIRT493902 FAM43A family with sequence similarity 43 member A 2 4
MIRT495969 TBC1D19 TBC1 domain family member 19 2 2
MIRT496113 SNX17 sorting nexin 17 2 2
MIRT497876 SLC12A7 solute carrier family 12 member 7 2 2
MIRT498118 PLEKHO1 pleckstrin homology domain containing O1 2 4
MIRT499406 PLCG2 phospholipase C gamma 2 2 4
MIRT499494 GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 2 2
MIRT499654 SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 2 2
MIRT499943 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT499998 HIST1H2BD histone cluster 1 H2B family member d 2 4
MIRT500899 STRN striatin 2 4
MIRT501113 SLC5A6 solute carrier family 5 member 6 2 4
MIRT501209 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT501247 SEMA4C semaphorin 4C 2 6
MIRT501327 RNFT1 ring finger protein, transmembrane 1 2 2
MIRT501349 RNF44 ring finger protein 44 2 4
MIRT501388 RBFOX2 RNA binding protein, fox-1 homolog 2 2 10
MIRT501442 RAB11FIP4 RAB11 family interacting protein 4 2 2
MIRT501752 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT501941 MBD2 methyl-CpG binding domain protein 2 2 8
MIRT502121 KMT2D lysine methyltransferase 2D 2 4
MIRT502783 CEP135 centrosomal protein 135 2 2
MIRT502840 CELF1 CUGBP Elav-like family member 1 2 2
MIRT505579 SMC1A structural maintenance of chromosomes 1A 2 6
MIRT506360 NUP155 nucleoporin 155 2 6
MIRT507243 FIGN fidgetin, microtubule severing factor 2 8
MIRT507689 COIL coilin 2 6
MIRT508402 C1orf210 chromosome 1 open reading frame 210 2 6
MIRT508666 DIABLO diablo IAP-binding mitochondrial protein 2 4
MIRT508933 AK4 adenylate kinase 4 2 4
MIRT510392 ZNF566 zinc finger protein 566 2 6
MIRT510514 YOD1 YOD1 deubiquitinase 2 6
MIRT511387 IKZF3 IKAROS family zinc finger 3 2 4
MIRT512747 CD59 CD59 molecule (CD59 blood group) 2 4
MIRT515955 C9orf156 tRNA methyltransferase O 2 2
MIRT516084 ZBTB8OS zinc finger and BTB domain containing 8 opposite strand 2 4
MIRT521390 RDX radixin 2 4
MIRT522349 NCKIPSD NCK interacting protein with SH3 domain 2 4
MIRT523627 FZD9 frizzled class receptor 9 2 4
MIRT523734 FBXW2 F-box and WD repeat domain containing 2 2 4
MIRT523983 DVL3 dishevelled segment polarity protein 3 2 2
MIRT524115 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT525728 SOD2 superoxide dismutase 2 2 2
MIRT527764 RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator 2 2
MIRT529728 OPRL1 opioid related nociceptin receptor 1 2 2
MIRT533189 WASL Wiskott-Aldrich syndrome like 2 6
MIRT536379 LEFTY1 left-right determination factor 1 2 2
MIRT543786 RBM12B RNA binding motif protein 12B 2 4
MIRT543869 SLC16A9 solute carrier family 16 member 9 2 2
MIRT545388 PM20D2 peptidase M20 domain containing 2 2 2
MIRT546329 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT547372 MSI2 musashi RNA binding protein 2 2 2
MIRT547573 LRIG3 leucine rich repeats and immunoglobulin like domains 3 2 4
MIRT548266 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT548346 EPHA4 EPH receptor A4 2 2
MIRT548535 DUSP1 dual specificity phosphatase 1 2 2
MIRT548564 DNAL1 dynein axonemal light chain 1 2 2
MIRT548780 COLEC12 collectin subfamily member 12 2 2
MIRT548972 CCNT2 cyclin T2 2 2
MIRT549022 CBX5 chromobox 5 2 2
MIRT549207 BEND4 BEN domain containing 4 2 4
MIRT549764 ZNF611 zinc finger protein 611 2 6
MIRT549800 KIAA0391 KIAA0391 2 2
MIRT549848 ECHDC1 ethylmalonyl-CoA decarboxylase 1 2 2
MIRT550727 PMPCA peptidase, mitochondrial processing alpha subunit 2 4
MIRT550899 ACTA1 actin, alpha 1, skeletal muscle 2 2
MIRT551284 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 6
MIRT551319 GSG2 histone H3 associated protein kinase 2 6
MIRT552004 RAD18 RAD18, E3 ubiquitin protein ligase 2 2
MIRT552411 ZNF460 zinc finger protein 460 2 4
MIRT553018 USP38 ubiquitin specific peptidase 38 2 2
MIRT555551 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT555717 PDZD8 PDZ domain containing 8 2 2
MIRT557967 FAM222B family with sequence similarity 222 member B 2 2
MIRT559088 C19orf47 chromosome 19 open reading frame 47 2 4
MIRT559498 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 2
MIRT561776 PEG10 paternally expressed 10 2 2
MIRT564403 EMILIN2 elastin microfibril interfacer 2 2 4
MIRT565450 SURF4 surfeit 4 2 2
MIRT566519 PARP16 poly(ADP-ribose) polymerase family member 16 2 2
MIRT567430 GNG5 G protein subunit gamma 5 2 2
MIRT567718 E2F6 E2F transcription factor 6 2 2
MIRT568649 ABHD17C abhydrolase domain containing 17C 2 2
MIRT569499 THYN1 thymocyte nuclear protein 1 2 2
MIRT573821 TGOLN2 trans-golgi network protein 2 2 2
MIRT574364 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT574749 GOLGA4 golgin A4 2 2
MIRT576088 Poteg POTE ankyrin domain family, member G 2 2
MIRT576807 Thbs1 thrombospondin 1 2 3
MIRT616371 RWDD1 RWD domain containing 1 2 2
MIRT617852 FMO4 flavin containing monooxygenase 4 2 2
MIRT642395 ZNF556 zinc finger protein 556 2 2
MIRT680520 PRIM2 DNA primase subunit 2 2 2
MIRT680548 ZNF584 zinc finger protein 584 2 2
MIRT680801 ZNF578 zinc finger protein 578 2 2
MIRT680839 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT681142 INTS7 integrator complex subunit 7 2 2
MIRT681272 RFC2 replication factor C subunit 2 2 2
MIRT681324 ZFAND4 zinc finger AN1-type containing 4 2 4
MIRT681360 BRI3BP BRI3 binding protein 2 2
MIRT681507 STAT2 signal transducer and activator of transcription 2 2 2
MIRT681537 ZNF738 zinc finger protein 738 2 2
MIRT681659 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT681739 RAB19 RAB19, member RAS oncogene family 2 4
MIRT681761 CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 2 2
MIRT681798 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT681870 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT681942 SLC19A3 solute carrier family 19 member 3 2 2
MIRT682103 ITGA3 integrin subunit alpha 3 2 4
MIRT682182 SLC38A7 solute carrier family 38 member 7 2 2
MIRT682239 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT682385 PHACTR4 phosphatase and actin regulator 4 2 2
MIRT682445 MTX3 metaxin 3 2 2
MIRT682605 CPA4 carboxypeptidase A4 2 2
MIRT682641 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT689328 FPR1 formyl peptide receptor 1 2 2
MIRT689731 ATXN2 ataxin 2 2 2
MIRT691037 ZNF799 zinc finger protein 799 2 2
MIRT691936 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT694885 ZNF417 zinc finger protein 417 2 2
MIRT695256 ZNF443 zinc finger protein 443 2 2
MIRT695414 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT700588 PRSS22 protease, serine 22 2 2
MIRT701425 NHLRC2 NHL repeat containing 2 2 2
MIRT702485 KIAA1328 KIAA1328 2 2
MIRT702714 IPO9 importin 9 2 2
MIRT704030 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT704422 CTPS1 CTP synthase 1 2 2
MIRT705751 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT712372 NAP1L1 nucleosome assembly protein 1 like 1 2 2
MIRT713521 PAFAH2 platelet activating factor acetylhydrolase 2 2 2
MIRT734116 Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 3 0
MIRT734252 OPRM1 opioid receptor mu 1 3 0
MIRT735524 CD274 CD274 molecule 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
let-7d Benzene NULL 241 MiRNA PCR array white blood cell 24780745 2014 up-regulated
let-7d Benzene NULL 241 MiRNA PCR array blood mononuclear cells 24780745 2014 up-regulated
let-7d Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 down-regulated
let-7d Gemcitabine approved 60750 Northern blot Mz-ChA-1 human cholangiocarcinoma cell lines 16762633 2006 up-regulated
let-7d All-trans-retinoic acid (ATRA) approved 444795 Microarray acute promyelocytic leukemia 17260024 2008 up-regulated
let-7d 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
let-7d Cocaine NULL 446220 Quantitative real-time PCR HEK293 cells or rat brain parts 19703567 2009 down-regulated
let-7d Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
let-7d Ginsenoside Rh2 NULL 119307 Microarray human glioma cells U251 21372826 2011 up-regulated
let-7d 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 up-regulated
let-7d Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
let-7d CDF(analogues of curcumin) NULL NULL Quantitative real-time PCR pancreatic cancer cells 22108826 2012 up-regulated
let-7d Marine fungal metabolite 1386A NULL NULL Microarray MCF-7 breast cancer cells. 22159329 2012 down-regulated
let-7d 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
let-7d Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
let-7d Olea europaea leaf extract NULL NULL Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
let-7d Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
let-7d Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 up-regulated
let-7d Sevoflurane approved 5206 Quantitative real-time PCR lung cell 23124245 2012 down-regulated
let-7d Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 down-regulated
let-7d Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
let-7d Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-let-7d Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-let-7d Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (MIA-PaCa-2, PANC-1, Aspc-1, L3.6pl, Colo357, BXPC-3, HPAC)
hsa-let-7d Cisplatin 5460033 NSC119875 approved resistant High Tongue Squamous Cell Carcinoma cell line (Tca8113)
hsa-let-7d Imatinib 5291 NSC743414 approved resistant High Myelogenous Leukemia cell line (MYL)
hsa-let-7d Cisplatin 5460033 NSC119875 approved sensitive Low Oral Cancer Oral Cancer Tumor Initiating Cells
hsa-let-7d Paclitaxel 36314 NSC125973 approved sensitive Low Oral Cancer Oral Cancer Tumor Initiating Cells
hsa-let-7d Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3)
hsa-let-7d Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-let-7d Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (C13*, A2780, OV2008)
hsa-let-7d Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-let-7d Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-let-7d Imatinib 5291 NSC743414 approved resistant High Gastrointestinal Stromal Tumor tissue
hsa-let-7d Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-let-7d Cisplatin 5460033 NSC119875 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-let-7d Mitoxantrone 4212 NSC279836 approved resistant High Breast Cancer cell line (MCF-7)
hsa-let-7d Gefitinib 123631 NSC715055 approved sensitive High Non-Small Cell Lung Cancer cell line (HCC827)
hsa-let-7d 7-Difluoromethoxyl-5,4’-Di-N-Octylgenistein sensitive Low Ovarian Cancer cell line (SKOV3, OVCAR)
hsa-let-7d Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-let-7d Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-let-7d Gefitinib 123631 NSC715055 approved sensitive Low Non-Small Cell Lung Cancer cell line (PC-9)
hsa-let-7d Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375)
hsa-let-7d Osimertinib 71496458 NSC779217 approved sensitive Low Non-Small Cell Lung Cancer cell line (H1975)
hsa-let-7d Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-let-7d Vincristine 5978 approved sensitive cell line (W1)
hsa-let-7d Ribavirin+Pegylated IFNa-2b resistant tissue (chronic hepatitis C)
hsa-let-7d Methotrexate 126941 NSC740 approved sensitive cell line (HT29)
hsa-let-7d Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-let-7d Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-let-7d Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-let-7d Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR70)
hsa-let-7d Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-let-7d Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-let-7d Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-let-7d Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-let-7d-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-let-7d-5p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-let-7d-5p Platinum 23939 resistant Low Ovarian Cancer tissue
hsa-let-7d-5p Imatinib 5291 NSC743414 approved resistant High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-let-7d-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-let-7d-5p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-let-7d-5p Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-let-7d-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-let-7d-5p Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (2uM)
hsa-let-7d-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (2uM)
hsa-let-7d-5p Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (SKOV3, A2780, OVCAR-3, CaOV3)
hsa-let-7d-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-let-7d-5p Tivantinib 11494412 NSC758242 sensitive High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-let-7d-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CP20)
hsa-let-7d-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CIS)
hsa-let-7d-5p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-let-7d-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-let-7d-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-let-7d-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-let-7d-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-let-7d-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-let-7d-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-let-7d-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-let-7d-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-let-7d-5p Fluorouracil 3385 NSC19893 approved sensitive cell line (HCT15)
hsa-let-7d-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-let-7d-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-let-7d-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-let-7d-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (OVSAHO)

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