miRTarBase - #MIRT036259


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pre-miRNA Information
pre-miRNA hsa-mir-1229   
Genomic Coordinates chr5: 179798278 - 179798346
Synonyms MIRN1229, hsa-mir-1229, MIR1229
Description Homo sapiens miR-1229 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1229-3p
Sequence 47| CUCUCACCACUGCCCUCCCACAG |69
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN20086841 1 COSMIC
COSN16303113 8 COSMIC
COSM6273761 14 COSMIC
COSM1066702 23 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs754734738 1 dbSNP
rs1479021409 8 dbSNP
rs200647784 9 dbSNP
rs1429872559 12 dbSNP
rs1373546432 13 dbSNP
rs766644214 15 dbSNP
rs758465824 18 dbSNP
rs1396376879 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SORBS3   
Synonyms SCAM-1, SCAM1, SH3D4
Description sorbin and SH3 domain containing 3
Transcript NM_001018003   
Other Transcripts NM_005775   
Expression
Putative miRNA Targets on SORBS3
3'UTR of SORBS3
(miRNA target sites are highlighted)		 
>SORBS3|NM_001018003|3'UTR
   1 GTGGTCTCCATGGCAACTTGGAGCCAGCCAGGATGGGGTGGGGAGCGGTGGCACTCGTGGGAGGGAGAGGACCCCCGCCC
  81 ACATCCTCCTTCCCCAGGACCTGAGCTCCCAGCATCTGCAGACGACCCCCGCAGCCTTTCCCTCGGACCCCCCTCGAAGC
 161 CCCCTGGACTGATTCCCACCCACGACTCACAGGCATTCCTCCCACAGCCCTTTCATTTCCTCCCCACCCCACTCCCCAAA
 241 TACAGAGGTCTGCTTTGAAGCGGAGACCATTTCCAGGCCTTATTGAGACCAGACCCCAAGTCCCCCACCCCCATCCTGCT
 321 CCAGCGTTTCCTCTAACAGGGACCAGCTCTCCGCTTTGCCCCCACGGGGTTCCTCTAACCAGAACCAGCTTCCTAGCCTC
 401 GTAGAGACCAAAGGCCGCCCCCGCCTGCTGGGGTTCCTCCCAGCACCCCAGCTTGCTGGCTGCCCTCTTTGCCTTCTGGC
 481 CTCCAGCTGGGTGTGGGGGGGCGGAGCAAGGCGGGGGACAGACGCAGCACCTTCTTAGCGATCTAGGCCTGGCAAGAGCT
 561 CTGGCCCCAAGGCCTCCTCTTCCCAGGGGCTGCCAAGTCCTGGCCCTGGCCCTGGCATATCACCCCGCACTGTGGGGCCA
 641 GGCACCACTAGCCTGGCTCAAATATTCCCCAGGGAGACTGCTGTGTGCTGCCCGCCTGCCTGCTGGCTCTCCCCCAGCCC
 721 CACATCCCCTCTGGAAGAGAATGTAAAATAAACCTGGACACAAGGGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaCA-CCCUC----CCGUCACCACUCUc 5'
            || |||||    |||| | |||:|| 
Target 5' ggGTGGGGAGCGGTGGCACTCGTGGGAg 3'
 36 - 63 127.00 -27.40
2 
miRNA  3' gaCACCCUCCCGUC----ACCACUCUc 5'
            |||||:||||:|     || |:|: 
Target 5' gtGTGGGGGGGCGGAGCAAGGCGGGGg 3'
 491 - 517 111.00 -32.90
3 
miRNA  3' gacacccucccgucaccACUCUc 5'
                           ||||| 
Target 5' ccatttccaggccttatTGAGAc 3'
 267 - 289 100.00 -6.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN29513587 2 COSMIC
COSN30163891 7 COSMIC
COSN31556137 14 COSMIC
COSN30554513 24 COSMIC
COSN20120493 40 COSMIC
COSN30468598 64 COSMIC
COSN30468370 65 COSMIC
COSN24391702 78 COSMIC
COSN23987348 82 COSMIC
COSN30486945 93 COSMIC
COSN30487575 94 COSMIC
COSN28854540 103 COSMIC
COSN31973007 109 COSMIC
COSN510870 136 COSMIC
COSN28162399 137 COSMIC
COSN30486376 156 COSMIC
COSN31964341 163 COSMIC
COSN32069829 166 COSMIC
COSN29822180 227 COSMIC
COSN28883102 348 COSMIC
COSN22890779 359 COSMIC
COSN26556893 402 COSMIC
COSN24294965 504 COSMIC
COSN31589124 513 COSMIC
COSN5678737 672 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1464285138 2 dbSNP
rs1265961336 10 dbSNP
rs750324261 12 dbSNP
rs995465713 16 dbSNP
rs758298245 25 dbSNP
rs1382118579 27 dbSNP
rs1490198818 29 dbSNP
rs1026994593 30 dbSNP
rs1802146 31 dbSNP
rs779829297 35 dbSNP
rs746791214 37 dbSNP
rs1223992356 38 dbSNP
rs755210819 39 dbSNP
rs879076407 44 dbSNP
rs750614064 47 dbSNP
rs781437016 47 dbSNP
rs748209182 48 dbSNP
rs1310650182 50 dbSNP
rs769818184 55 dbSNP
rs528385361 57 dbSNP
rs1483471119 59 dbSNP
rs771357591 60 dbSNP
rs774764584 64 dbSNP
rs759886430 69 dbSNP
rs763807603 70 dbSNP
rs760906030 72 dbSNP
rs776472146 73 dbSNP
rs761578924 74 dbSNP
rs764799698 75 dbSNP
rs749902459 76 dbSNP
rs758295158 77 dbSNP
rs766280515 78 dbSNP
rs754820094 79 dbSNP
rs780991836 83 dbSNP
rs1365582841 84 dbSNP
rs1015150736 86 dbSNP
rs748331954 87 dbSNP
rs756335968 94 dbSNP
rs1327841442 95 dbSNP
rs1227553838 98 dbSNP
rs749388158 99 dbSNP
rs771464649 101 dbSNP
rs779330060 103 dbSNP
rs1251791043 107 dbSNP
rs546826080 108 dbSNP
rs759872054 110 dbSNP
rs776027066 111 dbSNP
rs953252619 118 dbSNP
rs1418213757 120 dbSNP
rs1427241112 122 dbSNP
rs1192996874 123 dbSNP
rs571373802 124 dbSNP
rs1414670718 126 dbSNP
rs769580470 127 dbSNP
rs772763639 129 dbSNP
rs974950552 130 dbSNP
rs762433051 131 dbSNP
rs1294233590 132 dbSNP
rs710098 137 dbSNP
rs1383104780 138 dbSNP
rs550294683 141 dbSNP
rs759503087 143 dbSNP
rs767236708 146 dbSNP
rs1220443610 147 dbSNP
rs1248828975 148 dbSNP
rs372859083 149 dbSNP
rs11986365 150 dbSNP
rs1319898667 151 dbSNP
rs777924894 153 dbSNP
rs753923889 154 dbSNP
rs1404552879 155 dbSNP
rs757329169 156 dbSNP
rs779072491 160 dbSNP
rs746335735 161 dbSNP
rs772710002 162 dbSNP
rs1407400027 163 dbSNP
rs142500132 166 dbSNP
rs1412218562 170 dbSNP
rs1041976433 175 dbSNP
rs928783367 176 dbSNP
rs747433591 180 dbSNP
rs1354021763 181 dbSNP
rs769561886 184 dbSNP
rs144092952 187 dbSNP
rs756580182 194 dbSNP
rs1351389901 196 dbSNP
rs762693399 198 dbSNP
rs1283451232 203 dbSNP
rs1384009789 204 dbSNP
rs1376867513 205 dbSNP
rs916276714 208 dbSNP
rs1229970651 209 dbSNP
rs188618445 211 dbSNP
rs867623624 215 dbSNP
rs1159994337 216 dbSNP
rs1237455717 218 dbSNP
rs1340882145 221 dbSNP
rs1310375210 226 dbSNP
rs1202523668 227 dbSNP
rs566420370 229 dbSNP
rs1276302607 231 dbSNP
rs1483200816 232 dbSNP
rs1187273749 242 dbSNP
rs773920041 244 dbSNP
rs778207621 253 dbSNP
rs1048423972 262 dbSNP
rs887127383 263 dbSNP
rs1288603562 268 dbSNP
rs1381142381 271 dbSNP
rs1447710472 278 dbSNP
rs1383275945 283 dbSNP
rs930876799 284 dbSNP
rs1371398895 294 dbSNP
rs1434400616 300 dbSNP
rs1443752533 307 dbSNP
rs1349945680 311 dbSNP
rs1439793775 312 dbSNP
rs1323403534 324 dbSNP
rs1047994047 326 dbSNP
rs1004788297 327 dbSNP
rs1369263913 332 dbSNP
rs1213845053 338 dbSNP
rs1355301407 352 dbSNP
rs1286279657 353 dbSNP
rs534249779 354 dbSNP
rs1242712361 363 dbSNP
rs1280680408 364 dbSNP
rs546373520 366 dbSNP
rs1008816469 367 dbSNP
rs1397079532 374 dbSNP
rs1361869958 378 dbSNP
rs1287127993 380 dbSNP
rs191193955 383 dbSNP
rs1222540111 386 dbSNP
rs997321252 398 dbSNP
rs1163152810 399 dbSNP
rs1423000909 401 dbSNP
rs1029253281 402 dbSNP
rs1166657207 408 dbSNP
rs1335539338 410 dbSNP
rs1260942058 415 dbSNP
rs1213303420 416 dbSNP
rs182555024 418 dbSNP
rs989899914 423 dbSNP
rs754215028 424 dbSNP
rs1458942810 433 dbSNP
rs544800143 434 dbSNP
rs1267531499 436 dbSNP
rs556742671 441 dbSNP
rs574979052 452 dbSNP
rs1221057567 456 dbSNP
rs1276828164 456 dbSNP
rs1341161503 457 dbSNP
rs1030900130 464 dbSNP
rs960616138 465 dbSNP
rs992200813 466 dbSNP
rs916281222 467 dbSNP
rs938938915 470 dbSNP
rs542303279 471 dbSNP
rs1468592056 478 dbSNP
rs1372329340 481 dbSNP
rs1164925478 482 dbSNP
rs1168418781 485 dbSNP
rs916103299 486 dbSNP
rs188370599 489 dbSNP
rs751422180 495 dbSNP
rs973871990 495 dbSNP
rs931367460 496 dbSNP
rs1269000596 497 dbSNP
rs527656951 498 dbSNP
rs367730865 501 dbSNP
rs1319218920 502 dbSNP
rs887202334 503 dbSNP
rs939978562 504 dbSNP
rs778503203 513 dbSNP
rs565170362 514 dbSNP
rs997879280 518 dbSNP
rs1028825933 523 dbSNP
rs1391086723 523 dbSNP
rs532203187 524 dbSNP
rs745481602 528 dbSNP
rs781281137 532 dbSNP
rs550356186 535 dbSNP
rs1335563589 539 dbSNP
rs1047073 544 dbSNP
rs1171981955 549 dbSNP
rs1030846302 557 dbSNP
rs960604750 558 dbSNP
rs1164098810 559 dbSNP
rs1199076609 561 dbSNP
rs568650864 564 dbSNP
rs745861729 571 dbSNP
rs1271538392 574 dbSNP
rs967119881 577 dbSNP
rs969107916 580 dbSNP
rs1263059799 581 dbSNP
rs867924038 589 dbSNP
rs977076816 590 dbSNP
rs1347186083 595 dbSNP
rs1238550693 601 dbSNP
rs1374954919 603 dbSNP
rs1306729621 604 dbSNP
rs796285534 610 dbSNP
rs1272112685 615 dbSNP
rs1435797120 620 dbSNP
rs529746182 627 dbSNP
rs548218784 628 dbSNP
rs1403676109 637 dbSNP
rs960317218 638 dbSNP
rs1172664879 646 dbSNP
rs1418654622 658 dbSNP
rs758877824 658 dbSNP
rs566362434 662 dbSNP
rs1160157516 664 dbSNP
rs983576918 668 dbSNP
rs569543401 674 dbSNP
rs1444664962 677 dbSNP
rs944937588 683 dbSNP
rs559017501 684 dbSNP
rs1425120003 686 dbSNP
rs922191823 687 dbSNP
rs530642132 691 dbSNP
rs571159766 692 dbSNP
rs538482957 694 dbSNP
rs191722898 695 dbSNP
rs1445650140 699 dbSNP
rs1396224994 707 dbSNP
rs777326935 712 dbSNP
rs1334817781 714 dbSNP
rs1047146 723 dbSNP
rs1336742788 724 dbSNP
rs1398845671 727 dbSNP
rs111538363 729 dbSNP
rs1414670464 730 dbSNP
rs1291578709 732 dbSNP
rs1043749714 737 dbSNP
rs1047151 738 dbSNP
rs1161831599 740 dbSNP
rs903904332 758 dbSNP
rs1041045113 759 dbSNP
rs554204827 762 dbSNP
rs1487329838 766 dbSNP
rs1265460493 768 dbSNP
rs1217574928 770 dbSNP
rs1490250336 772 dbSNP
rs1288813395 775 dbSNP
rs1052265105 780 dbSNP
rs572382148 781 dbSNP
rs746504903 782 dbSNP
rs546155455 793 dbSNP
rs184028803 798 dbSNP
rs187583207 809 dbSNP
rs889045746 815 dbSNP
rs1400157927 816 dbSNP
rs1348953367 820 dbSNP
rs1337233990 827 dbSNP
rs779482020 831 dbSNP
rs1011341445 834 dbSNP
rs544057726 842 dbSNP
rs1201926962 845 dbSNP
rs1042873764 849 dbSNP
rs768626304 852 dbSNP
rs562343288 858 dbSNP
rs1391948922 863 dbSNP
rs547412023 872 dbSNP
rs371371372 874 dbSNP
rs1208620534 878 dbSNP
rs776482963 880 dbSNP
rs1194499549 883 dbSNP
rs1477773930 889 dbSNP
rs995142075 890 dbSNP
rs960004003 895 dbSNP
rs548831334 908 dbSNP
rs1273603006 912 dbSNP
rs1197885381 920 dbSNP
rs1315995228 928 dbSNP
rs1026643959 930 dbSNP
rs1218693067 937 dbSNP
rs1264785427 938 dbSNP
rs951132948 944 dbSNP
rs1438228392 945 dbSNP
rs1192037260 948 dbSNP
rs1464473507 952 dbSNP
rs982521867 953 dbSNP
rs908039110 958 dbSNP
rs1023197340 959 dbSNP
rs952941444 961 dbSNP
rs1175962243 972 dbSNP
rs1193084124 976 dbSNP
rs966209062 978 dbSNP
rs1376419696 993 dbSNP
rs1177786805 1000 dbSNP
rs1456317578 1009 dbSNP
rs984253609 1011 dbSNP
rs922169497 1013 dbSNP
rs1311078881 1022 dbSNP
rs908746374 1032 dbSNP
rs1275937018 1035 dbSNP
rs1220532848 1041 dbSNP
rs369237872 1045 dbSNP
rs1308158942 1051 dbSNP
rs1445020904 1054 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.701 6.8e-5 0.635 4.3e-4 24 Click to see details
GSE28260 Renal cortex and medulla -0.624 1.1e-2 -0.505 3.9e-2 13 Click to see details
GSE42095 Differentiated embryonic stem cells 0.391 3.3e-2 0.593 1.4e-3 23 Click to see details
GSE21687 Ependynoma primary tumors -0.202 5.5e-2 -0.128 1.6e-1 64 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.541 6.6e-2 0.683 2.1e-2 9 Click to see details
GSE19783 ER+ ER+ breast cancer 0.313 9.0e-2 0.168 2.4e-1 20 Click to see details
GSE38226 Liver fibrosis 0.299 9.4e-2 0.219 1.7e-1 21 Click to see details
GSE19536 Breast cancer 0.09 1.9e-1 0.180 3.7e-2 100 Click to see details
GSE26953 Aortic valvular endothelial cells 0.184 1.9e-1 -0.067 3.8e-1 24 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.177 2.0e-1 0.164 2.2e-1 25 Click to see details
GSE19350 CNS germ cell tumors -0.175 2.9e-1 -0.173 3.0e-1 12 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.082 3.5e-1 0.106 3.1e-1 25 Click to see details
GSE14794 Lymphoblastoid cells 0.039 3.6e-1 0.010 4.6e-1 90 Click to see details
GSE21032 Prostate cancer 0.038 3.7e-1 0.037 3.7e-1 83 Click to see details
GSE32688 Pancreatic cancer -0.061 3.7e-1 -0.063 3.7e-1 32 Click to see details
GSE17498 Multiple myeloma 0.039 4.1e-1 0.219 8.7e-2 40 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.042 4.3e-1 0.192 2.1e-1 20 Click to see details
GSE19783 ER- ER- breast cancer 0.003 4.9e-1 0.087 2.2e-1 79 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KICH 0.672 0.01 0.703 0 13 Click to see details
PAAD -0.969 0.02 -0.800 0.1 4 Click to see details
LUSC -0.375 0.05 -0.135 0.28 21 Click to see details
KIRC -0.237 0.05 -0.244 0.04 51 Click to see details
BRCA -0.242 0.06 -0.234 0.07 42 Click to see details
LUAD 0.58 0.21 0.800 0.1 4 Click to see details
THCA 0.14 0.21 -0.139 0.22 34 Click to see details
STAD -0.164 0.27 -0.053 0.42 16 Click to see details
HNSC -0.214 0.28 -0.127 0.36 10 Click to see details
BLCA 0.274 0.3 0.543 0.13 6 Click to see details
UCEC 0.179 0.32 -0.183 0.32 9 Click to see details
COAD -0.33 0.34 -0.800 0.1 4 Click to see details
PRAD 0.202 0.37 0.100 0.44 5 Click to see details
KIRP -0.043 0.42 0.155 0.23 24 Click to see details
LIHC -0.018 0.46 0.006 0.49 30 Click to see details
CHOL -0.023 0.49 -0.400 0.3 4 Click to see details
CHOL -0.023 0.49 -0.400 0.3 4 Click to see details
CHOL -0.023 0.49 -0.400 0.3 4 Click to see details
CHOL -0.023 0.49 -0.400 0.3 4 Click to see details
CHOL -0.023 0.49 -0.400 0.3 4 Click to see details
CHOL -0.023 0.49 -0.400 0.3 4 Click to see details
196 hsa-miR-1229-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT036258 VWA8 von Willebrand factor A domain containing 8 1 1
MIRT036259 SORBS3 sorbin and SH3 domain containing 3 1 1
MIRT036260 HIST1H3A histone cluster 1 H3 family member a 1 1
MIRT036261 TIA1 TIA1 cytotoxic granule associated RNA binding protein 1 1
MIRT036262 COIL coilin 1 1
MIRT036263 PBRM1 polybromo 1 1 1
MIRT036264 KRT28 keratin 28 1 1
MIRT036265 RPL7A ribosomal protein L7a 1 1
MIRT036266 EEF2 eukaryotic translation elongation factor 2 1 1
MIRT036267 CEP152 centrosomal protein 152 1 1
MIRT036268 CPT1B carnitine palmitoyltransferase 1B 1 1
MIRT036269 CEP55 centrosomal protein 55 1 1
MIRT036270 ZMYM2 zinc finger MYM-type containing 2 1 1
MIRT036271 CRISP3 cysteine rich secretory protein 3 1 1
MIRT036272 CDKN1A cyclin dependent kinase inhibitor 1A 1 1
MIRT036273 ADPRHL2 ADP-ribosylhydrolase like 2 1 1
MIRT036274 PHRF1 PHD and ring finger domains 1 1 1
MIRT036275 RPL3 ribosomal protein L3 1 1
MIRT036276 CSDE1 cold shock domain containing E1 1 1
MIRT036277 PTPRF protein tyrosine phosphatase, receptor type F 1 1
MIRT036278 ZNF264 zinc finger protein 264 1 1
MIRT036279 AHCYL1 adenosylhomocysteinase like 1 1 1
MIRT036280 GAPDH glyceraldehyde-3-phosphate dehydrogenase 1 1
MIRT036281 INTS10 integrator complex subunit 10 1 1
MIRT036282 TARDBP TAR DNA binding protein 1 1
MIRT036283 CTNND1 catenin delta 1 1 1
MIRT036284 KCTD15 potassium channel tetramerization domain containing 15 1 1
MIRT036285 CEP350 centrosomal protein 350 1 1
MIRT036286 C19orf10 myeloid derived growth factor 1 1
MIRT036287 TNRC6B trinucleotide repeat containing 6B 1 1
MIRT036288 CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 1 1
MIRT036289 POLR2D RNA polymerase II subunit D 1 1
MIRT036290 PHC1 polyhomeotic homolog 1 1 1
MIRT036291 HNRNPD heterogeneous nuclear ribonucleoprotein D 1 1
MIRT036292 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 1 1
MIRT036293 AIF1L allograft inflammatory factor 1 like 1 1
MIRT036294 NEU3 neuraminidase 3 1 1
MIRT036295 DCTD dCMP deaminase 1 1
MIRT036296 TUBA1B tubulin alpha 1b 1 1
MIRT036297 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 1 1
MIRT036298 ACOT7 acyl-CoA thioesterase 7 1 1
MIRT036299 MDK midkine 1 1
MIRT036300 INO80D INO80 complex subunit D 1 1
MIRT036301 LDOC1L retrotransposon Gag like 6 1 1
MIRT036302 C2orf44 WD repeat and coiled coil containing 1 1
MIRT036303 SRCAP Snf2 related CREBBP activator protein 1 1
MIRT036304 EPB41L2 erythrocyte membrane protein band 4.1 like 2 1 1
MIRT036305 REXO2 RNA exonuclease 2 1 1
MIRT036306 CTNNBL1 catenin beta like 1 1 1
MIRT036307 SAFB scaffold attachment factor B 1 1
MIRT036308 PPP6R1 protein phosphatase 6 regulatory subunit 1 1 1
MIRT036309 FEN1 flap structure-specific endonuclease 1 1 1
MIRT036310 LRBA LPS responsive beige-like anchor protein 1 1
MIRT036311 SCAMP5 secretory carrier membrane protein 5 1 1
MIRT036312 DAG1 dystroglycan 1 1 1
MIRT036313 HYPK huntingtin interacting protein K 1 1
MIRT036314 HIST1H4C histone cluster 1 H4 family member c 1 1
MIRT036315 CDC42EP4 CDC42 effector protein 4 1 1
MIRT036316 ERC1 ELKS/RAB6-interacting/CAST family member 1 1 1
MIRT036317 GTF2I general transcription factor IIi 1 1
MIRT036318 RPGRIP1L RPGRIP1 like 1 1
MIRT036319 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 1 1
MIRT036320 TRRAP transformation/transcription domain associated protein 1 1
MIRT036321 PHF8 PHD finger protein 8 1 1
MIRT036322 TSC22D3 TSC22 domain family member 3 1 1
MIRT036323 MPP2 membrane palmitoylated protein 2 1 1
MIRT036324 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 1 1
MIRT036325 ALS2 ALS2, alsin Rho guanine nucleotide exchange factor 1 1
MIRT036326 KMT2D lysine methyltransferase 2D 1 1
MIRT036327 ITGA5 integrin subunit alpha 5 1 1
MIRT036328 ABCC5 ATP binding cassette subfamily C member 5 1 1
MIRT036329 KIF24 kinesin family member 24 1 1
MIRT036330 PPP4C protein phosphatase 4 catalytic subunit 1 1
MIRT036331 FMNL2 formin like 2 1 1
MIRT036332 NF2 neurofibromin 2 1 1
MIRT036333 NUP210 nucleoporin 210 1 1
MIRT036334 CTDNEP1 CTD nuclear envelope phosphatase 1 1 1
MIRT036335 EIF4G2 eukaryotic translation initiation factor 4 gamma 2 1 1
MIRT036336 CTCF CCCTC-binding factor 1 1
MIRT036337 LRIT1 leucine rich repeat, Ig-like and transmembrane domains 1 1 1
MIRT036338 SFPQ splicing factor proline and glutamine rich 1 1
MIRT036339 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1 1
MIRT036340 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 1 1
MIRT036341 SLC39A7 solute carrier family 39 member 7 1 1
MIRT036342 KDM5C lysine demethylase 5C 1 1
MIRT036343 ACLY ATP citrate lyase 1 1
MIRT036344 MED19 mediator complex subunit 19 1 1
MIRT036345 SRP72 signal recognition particle 72 1 1
MIRT036346 RUVBL2 RuvB like AAA ATPase 2 1 1
MIRT036347 CLSTN3 calsyntenin 3 1 1
MIRT036348 SAE1 SUMO1 activating enzyme subunit 1 1 1
MIRT036349 TUBG1 tubulin gamma 1 1 1
MIRT036350 FOXP1 forkhead box P1 1 1
MIRT036351 ZNF687 zinc finger protein 687 1 1
MIRT036352 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 1 1
MIRT036353 HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 1 1
MIRT036354 RNF40 ring finger protein 40 1 1
MIRT036355 KPNB1 karyopherin subunit beta 1 1 1
MIRT036356 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 1 1
MIRT036357 DDX23 DEAD-box helicase 23 1 1
MIRT036358 BET1L Bet1 golgi vesicular membrane trafficking protein like 1 1
MIRT036359 BRD2 bromodomain containing 2 1 1
MIRT036360 EML1 echinoderm microtubule associated protein like 1 1 1
MIRT036361 BAP1 BRCA1 associated protein 1 1 1
MIRT036362 STAT5B signal transducer and activator of transcription 5B 1 1
MIRT036363 SUPT5H SPT5 homolog, DSIF elongation factor subunit 1 1
MIRT036364 GPI glucose-6-phosphate isomerase 1 1
MIRT036365 PTBP3 polypyrimidine tract binding protein 3 1 1
MIRT036366 RPS15 ribosomal protein S15 1 1
MIRT036367 ZDHHC7 zinc finger DHHC-type containing 7 1 1
MIRT036368 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 1 1
MIRT036369 SNX12 sorting nexin 12 1 1
MIRT036370 OTUD7B OTU deubiquitinase 7B 1 1
MIRT036371 AP2M1 adaptor related protein complex 2 mu 1 subunit 1 1
MIRT036372 C9orf114 SPOUT domain containing methyltransferase 1 1 1
MIRT036373 MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 1 1
MIRT036374 FOXK1 forkhead box K1 1 1
MIRT036375 SIK2 salt inducible kinase 2 1 1
MIRT036376 SCD stearoyl-CoA desaturase 1 1
MIRT036377 PHGDH phosphoglycerate dehydrogenase 1 1
MIRT036378 PITPNB phosphatidylinositol transfer protein beta 1 1
MIRT036379 MAD2L2 mitotic arrest deficient 2 like 2 1 1
MIRT036380 TUSC3 tumor suppressor candidate 3 1 1
MIRT036381 PRKRIP1 PRKR interacting protein 1 1 1
MIRT036382 DCAF7 DDB1 and CUL4 associated factor 7 1 1
MIRT036383 NME2 NME/NM23 nucleoside diphosphate kinase 2 1 1
MIRT036384 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 1 1
MIRT036385 SLC16A13 solute carrier family 16 member 13 1 1
MIRT036386 PRDX4 peroxiredoxin 4 1 1
MIRT036387 NXPE3 neurexophilin and PC-esterase domain family member 3 1 1
MIRT036388 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 1 1
MIRT036389 CPNE1 copine 1 1 1
MIRT036390 PSMC5 proteasome 26S subunit, ATPase 5 1 1
MIRT036391 PAK4 p21 (RAC1) activated kinase 4 1 1
MIRT059262 CELF1 CUGBP Elav-like family member 1 2 2
MIRT061283 IPO7 importin 7 2 2
MIRT080097 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT345981 BIRC5 baculoviral IAP repeat containing 5 2 8
MIRT366471 KLHL15 kelch like family member 15 2 2
MIRT379534 HNRNPK heterogeneous nuclear ribonucleoprotein K 2 2
MIRT443697 HUNK hormonally up-regulated Neu-associated kinase 2 4
MIRT472347 NETO2 neuropilin and tolloid like 2 2 2
MIRT497842 GATA6 GATA binding protein 6 2 4
MIRT510408 ZNF268 zinc finger protein 268 2 4
MIRT519621 ZNF781 zinc finger protein 781 2 2
MIRT519830 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT530712 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT530802 GPR182 G protein-coupled receptor 182 2 2
MIRT534374 SETD7 SET domain containing lysine methyltransferase 7 2 2
MIRT535541 P2RY2 purinergic receptor P2Y2 2 2
MIRT536016 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT556019 MYBL1 MYB proto-oncogene like 1 2 2
MIRT560009 ZNF525 zinc finger protein 525 2 2
MIRT560072 ZNF195 zinc finger protein 195 2 2
MIRT565948 RRAGD Ras related GTP binding D 2 2
MIRT570131 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT570887 ZNF780A zinc finger protein 780A 2 4
MIRT609775 VWC2L von Willebrand factor C domain containing protein 2 like 2 4
MIRT611445 NRIP3 nuclear receptor interacting protein 3 2 2
MIRT611975 ZNF175 zinc finger protein 175 2 2
MIRT612871 IGFBP5 insulin like growth factor binding protein 5 2 4
MIRT613012 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT617515 PTDSS1 phosphatidylserine synthase 1 2 2
MIRT636095 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT637442 ZNF324B zinc finger protein 324B 2 2
MIRT638303 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT638920 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT640590 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT646760 WDR3 WD repeat domain 3 2 2
MIRT652591 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654866 PPL periplakin 2 2
MIRT654952 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT656021 MYO5B myosin VB 2 2
MIRT657078 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657880 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT659231 CXCR5 C-X-C motif chemokine receptor 5 2 2
MIRT662904 MED18 mediator complex subunit 18 2 2
MIRT685610 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT687424 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT692293 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT693749 ZNF383 zinc finger protein 383 2 2
MIRT695121 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695138 PRY PTPN13-like, Y-linked 2 2
MIRT709581 LETMD1 LETM1 domain containing 1 2 2
MIRT709737 TRIM27 tripartite motif containing 27 2 2
MIRT711058 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT714189 TRAF7 TNF receptor associated factor 7 2 2
MIRT715924 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT719463 SRF serum response factor 2 2
MIRT720172 PANK2 pantothenate kinase 2 2 2
MIRT720456 RAB31 RAB31, member RAS oncogene family 2 2
MIRT721642 ZNF207 zinc finger protein 207 2 2
MIRT721996 CLLU1OS chronic lymphocytic leukemia up-regulated 1 opposite strand 2 2
MIRT722187 DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 2 2
MIRT725196 PTRF caveolae associated protein 1 2 2
MIRT725518 FAM229B family with sequence similarity 229 member B 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1229 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 down-regulated
miR-1229 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1229 Goserelin approved 47725 Microarray prostate 22674191 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1229 Fluorouracil 3385 NSC19893 approved sensitive cell line (KYSE)
hsa-miR-1229-3p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-1229-3p Doxorubicin 31703 NSC123127 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-1229-3p Fluorouracil 3385 NSC19893 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-1229-3p Vincristine 5978 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-1229-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-1229-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-1229-3p Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma cell line (Huh-7, PLC)
hsa-miR-1229-3p Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-1229-3p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-1229-3p Fluorouracil 3385 NSC19893 approved resistant Low Gastric Cancer cell line (HGC-27, GFP-MKN45)
hsa-miR-1229-3p Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma cell line (Huh-7, PLC)
hsa-miR-1229-3p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-1229-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-1229-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-1229-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-1229-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1229-3p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-1229-3p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-1229-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1229-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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