miRTarBase - #MIRT036271


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pre-miRNA Information
pre-miRNA hsa-mir-1229   
Genomic Coordinates chr5: 179798278 - 179798346
Synonyms MIRN1229, hsa-mir-1229, MIR1229
Description Homo sapiens miR-1229 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1229-3p
Sequence 47| CUCUCACCACUGCCCUCCCACAG |69
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN20086841 1 COSMIC
COSN16303113 8 COSMIC
COSM6273761 14 COSMIC
COSM1066702 23 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs754734738 1 dbSNP
rs1479021409 8 dbSNP
rs200647784 9 dbSNP
rs1429872559 12 dbSNP
rs1373546432 13 dbSNP
rs766644214 15 dbSNP
rs758465824 18 dbSNP
rs1396376879 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CRISP3   
Synonyms Aeg2, CRISP-3, CRS3, SGP28, dJ442L6.3
Description cysteine rich secretory protein 3
Transcript NM_006061   
Expression
Putative miRNA Targets on CRISP3
3'UTR of CRISP3
(miRNA target sites are highlighted)		 
>CRISP3|NM_006061|3'UTR
   1 ATACGCATTACACACCGAGTAGGGCTATGTAGAGAGGAGTCAGATTATCTACTTAGATTTGGCATCTACTTAGATTTAAC
  81 ATATACTAGCTGAGAAATTGTAGGCATGTTTGATACACATTTGATTTCAAATGTTTTTCTTCTGGATCTGCTTTTTATTT
 161 TACAAAAATATTTTTCATACAAATGGTTAAAAAGAAACAAAATCTATAACAACAACTTTGGATTTTTATATATAAACTTT
 241 GTGATTTAAATTTACTGAATTTAATTAGGGTGAAAATTTTGAAAGTTGTATTCTCATATGACTAAGTTCACTAAAACCCT
 321 GGATTGAAAGTGAAAATTATGTTCCTAGAACAAAATGTACAAAAAGAACAATATAATTTTCACATGAACCCTTGGCTGTA
 401 GTTGCCTTTCCTAGCTCCACTCTAAGGCTAAGCATCTTCAAAGACGTTTTCCCATATGCTGTCTTAATTCTTTTCACTCA
 481 TTCACCCTTCTTCCCAATCATCTGGCTGGCATCCTCACAATTGAGTTGAAGCTGTTCCTCCTAAAACAATCCTGACTTTT
 561 ATTTTGCCAAAATCAATACAATCCTTTGAATTTTTTATCTGCATAAATTTTACAGTAGAATATGATCAAACCTTCATTTT
 641 TAAACCTCTCTTCTCTTTGACAAAACTTCCTTAAAAAAGAATACAAGATAATATAGGTAAATACCCTCCACTCAAGGAGG
 721 TAGAACTCAGTCCTCTCCCTTGTGAGTCTTCACTAAAATCAGTGACTCACTTCCAAAGAGTGGAGTATGGAAAGGGAAAC
 801 ATAGTAACTTTACAGGGGAGAAAAATGACAAATGACGTCTTCACCAAGTGATCAAAATTAACGTCACCAGTGATAAGTCA
 881 TTCAGATTTGTTCTAGATAATCTTTCTAAAAATTCATAATCCCAATCTAATTATGAGCTAAAACATCCAGCAAACTCAAG
 961 TTGAAGGACATTCTACAAAATATCCCTGGGGTATTTTAGAGTATTCCTCAAAACTGTAAAAATCATGGAAAATAAGGGAA
1041 TCCTGAGAAACAATCACAGACCACATGAGACTAAGGAGACATGTGAGCCAAATGCAATGTGCTTCTTGGATCAGATCCTG
1121 GAACAGAAAAAGATCAGTAATGAAAAAACTGATGAAGTCTGAATAGAATCTGGAGTATTTTTAACAGTAGTGTTGATTTC
1201 TTAATCTTGATAAATATAGCAGGGTAATGTAAGATGATAACGTTAGAGAAACTGAAACTGGGTGAGGGCTATCTAGGAAT
1281 TCTCTGTACTATCTTACCAAATTTTCGGTAAGTCTAAGAAAGCAATGCAAAATAAAAAGTGTCTTGAAAAAAAAAAAAAA
1361 AAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaCACCCUC-----CCGUCA-CCACUCUc 5'
            ||  |||     |  | | ||||||: 
Target 5' acGTTAGAGAAACTGAAACTGGGTGAGGg 3'
 1240 - 1268 125.00 -15.70
2 
miRNA  3' gacacccucccGUCACCACUCUc 5'
                     :|| ||||| | 
Target 5' ctgaatttaatTAG-GGTGAAAa 3'
 255 - 276 111.00 -7.31
3 
miRNA  3' gacacccucccgucaCCACUCUc 5'
                         || |||| 
Target 5' catagtaactttacaGGGGAGAa 3'
 800 - 822 108.00 -9.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN2165142 4 COSMIC
COSN30487522 32 COSMIC
COSN30184835 43 COSMIC
COSN30457124 49 COSMIC
COSN31509036 49 COSMIC
COSN30486565 56 COSMIC
COSN20075607 89 COSMIC
COSN30181098 90 COSMIC
COSN2165141 112 COSMIC
COSN31506932 116 COSMIC
COSN30485879 128 COSMIC
COSN30499755 148 COSMIC
COSN30477096 156 COSMIC
COSN5088779 313 COSMIC
COSN23088642 359 COSMIC
COSN6323079 465 COSMIC
COSN9785909 610 COSMIC
COSN15277205 740 COSMIC
COSN23478329 1019 COSMIC
COSN9908475 1119 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1438797159 2 dbSNP
rs141178581 4 dbSNP
rs370404275 5 dbSNP
rs539748550 8 dbSNP
rs376111781 9 dbSNP
rs904091605 11 dbSNP
rs773704892 14 dbSNP
rs770524164 15 dbSNP
rs201154922 16 dbSNP
rs369501319 17 dbSNP
rs1192229655 22 dbSNP
rs894100272 23 dbSNP
rs534573630 25 dbSNP
rs368533417 26 dbSNP
rs746138268 30 dbSNP
rs375047362 31 dbSNP
rs1283680494 32 dbSNP
rs753711448 34 dbSNP
rs1432583476 37 dbSNP
rs777798725 39 dbSNP
rs752505185 42 dbSNP
rs1231920487 44 dbSNP
rs767464289 49 dbSNP
rs567226221 51 dbSNP
rs938412104 62 dbSNP
rs998840917 71 dbSNP
rs548925728 73 dbSNP
rs1310694431 75 dbSNP
rs1230202174 81 dbSNP
rs1263104422 84 dbSNP
rs577024447 87 dbSNP
rs1287424261 97 dbSNP
rs530803281 105 dbSNP
rs943550468 108 dbSNP
rs865810915 112 dbSNP
rs910688502 117 dbSNP
rs1430773571 118 dbSNP
rs1175583692 119 dbSNP
rs1372328878 120 dbSNP
rs919849174 121 dbSNP
rs1315875140 124 dbSNP
rs1344455948 125 dbSNP
rs1399614722 131 dbSNP
rs569760879 139 dbSNP
rs964083849 143 dbSNP
rs1221721186 150 dbSNP
rs1018247954 156 dbSNP
rs1351956168 168 dbSNP
rs746704096 175 dbSNP
rs868298960 176 dbSNP
rs1282594220 179 dbSNP
rs556698013 192 dbSNP
rs1222746912 200 dbSNP
rs1347569650 202 dbSNP
rs1489730644 206 dbSNP
rs1166294715 217 dbSNP
rs1363877160 219 dbSNP
rs1471116043 224 dbSNP
rs549065110 225 dbSNP
rs551563183 228 dbSNP
rs533502947 231 dbSNP
rs1406948454 235 dbSNP
rs779871663 240 dbSNP
rs1475295658 242 dbSNP
rs971780007 244 dbSNP
rs1367629363 245 dbSNP
rs559656066 254 dbSNP
rs1031203455 255 dbSNP
rs960362619 256 dbSNP
rs999681110 260 dbSNP
rs191056264 264 dbSNP
rs541633739 268 dbSNP
rs1336502032 271 dbSNP
rs537021326 275 dbSNP
rs969195306 282 dbSNP
rs894164808 286 dbSNP
rs1022103664 288 dbSNP
rs1247127643 289 dbSNP
rs1055360447 290 dbSNP
rs1012086738 295 dbSNP
rs938464191 299 dbSNP
rs1439093404 300 dbSNP
rs1179531532 305 dbSNP
rs906945949 306 dbSNP
rs1445189821 312 dbSNP
rs957503432 319 dbSNP
rs1383169221 322 dbSNP
rs145862348 323 dbSNP
rs1488459349 346 dbSNP
rs1397261155 348 dbSNP
rs1393260585 349 dbSNP
rs1263690371 356 dbSNP
rs1326954787 360 dbSNP
rs1376731436 361 dbSNP
rs1454001919 362 dbSNP
rs919719028 372 dbSNP
rs998894990 375 dbSNP
rs1267819880 382 dbSNP
rs1251581673 385 dbSNP
rs1341067346 392 dbSNP
rs974019040 395 dbSNP
rs942586949 401 dbSNP
rs1461667297 403 dbSNP
rs562380028 411 dbSNP
rs901835736 420 dbSNP
rs1352157012 425 dbSNP
rs911238415 426 dbSNP
rs1307473315 430 dbSNP
rs1386078250 441 dbSNP
rs1040656197 445 dbSNP
rs149841297 446 dbSNP
rs575311140 452 dbSNP
rs1031089450 454 dbSNP
rs1399726506 454 dbSNP
rs139992512 455 dbSNP
rs889297656 457 dbSNP
rs1461569351 458 dbSNP
rs769882794 470 dbSNP
rs1156563930 472 dbSNP
rs930789022 484 dbSNP
rs1458508379 485 dbSNP
rs897615552 486 dbSNP
rs544741897 491 dbSNP
rs1036516027 500 dbSNP
rs968248387 504 dbSNP
rs1224804825 507 dbSNP
rs939030783 510 dbSNP
rs11962574 513 dbSNP
rs927595301 515 dbSNP
rs1277003696 518 dbSNP
rs980672162 519 dbSNP
rs529394246 521 dbSNP
rs573251294 523 dbSNP
rs73441815 535 dbSNP
rs895391310 540 dbSNP
rs989350172 541 dbSNP
rs1408653639 543 dbSNP
rs1195579845 552 dbSNP
rs956743815 556 dbSNP
rs1191392351 558 dbSNP
rs1031789250 561 dbSNP
rs977468509 567 dbSNP
rs906993493 569 dbSNP
rs534517664 577 dbSNP
rs1465983393 581 dbSNP
rs1046817197 591 dbSNP
rs1387666188 598 dbSNP
rs1380164326 604 dbSNP
rs1297240188 606 dbSNP
rs1345567411 610 dbSNP
rs1207007375 617 dbSNP
rs745371685 625 dbSNP
rs1311462587 626 dbSNP
rs1239757866 627 dbSNP
rs1261031967 634 dbSNP
rs898345225 641 dbSNP
rs114410616 645 dbSNP
rs1214701818 646 dbSNP
rs1305588505 656 dbSNP
rs1007553223 659 dbSNP
rs942621536 659 dbSNP
rs1427304669 660 dbSNP
rs889399576 673 dbSNP
rs1028320732 675 dbSNP
rs1365878002 678 dbSNP
rs995052079 691 dbSNP
rs1452144304 694 dbSNP
rs1317990930 696 dbSNP
rs933987890 703 dbSNP
rs1365765889 704 dbSNP
rs897957063 705 dbSNP
rs568091309 708 dbSNP
rs753175347 710 dbSNP
rs1300677836 717 dbSNP
rs978220868 720 dbSNP
rs1159498136 721 dbSNP
rs968510085 723 dbSNP
rs939078478 724 dbSNP
rs1315082738 726 dbSNP
rs906220443 727 dbSNP
rs1176136895 733 dbSNP
rs1360368928 741 dbSNP
rs1225075833 743 dbSNP
rs1245050647 756 dbSNP
rs991379333 761 dbSNP
rs560203206 768 dbSNP
rs1253223176 769 dbSNP
rs1186768825 770 dbSNP
rs1448940773 774 dbSNP
rs947691756 775 dbSNP
rs1386258877 803 dbSNP
rs1035229675 807 dbSNP
rs1161329291 808 dbSNP
rs1348774548 810 dbSNP
rs1462009523 818 dbSNP
rs1299416606 821 dbSNP
rs915201233 828 dbSNP
rs989796036 833 dbSNP
rs935185230 836 dbSNP
rs971038020 837 dbSNP
rs923730150 844 dbSNP
rs780238828 850 dbSNP
rs1025706356 854 dbSNP
rs114021344 862 dbSNP
rs966147575 863 dbSNP
rs1019022224 865 dbSNP
rs1321372598 893 dbSNP
rs142931873 894 dbSNP
rs1341377938 897 dbSNP
rs1178624239 898 dbSNP
rs115082178 899 dbSNP
rs1006725357 900 dbSNP
rs547862968 917 dbSNP
rs1180504698 921 dbSNP
rs1412573637 932 dbSNP
rs533240448 937 dbSNP
rs139605287 938 dbSNP
rs1051011843 945 dbSNP
rs767922173 947 dbSNP
rs1326651740 949 dbSNP
rs933873718 951 dbSNP
rs995460278 953 dbSNP
rs1407999434 959 dbSNP
rs878909259 966 dbSNP
rs898014591 971 dbSNP
rs1450123816 977 dbSNP
rs534925417 984 dbSNP
rs946847191 986 dbSNP
rs1215391441 987 dbSNP
rs547973682 990 dbSNP
rs751881093 991 dbSNP
rs540302522 992 dbSNP
rs1044788316 994 dbSNP
rs766516083 997 dbSNP
rs982345408 1001 dbSNP
rs1208377384 1013 dbSNP
rs893428279 1015 dbSNP
rs1475530090 1018 dbSNP
rs1187967925 1023 dbSNP
rs377509588 1023 dbSNP
rs146340945 1025 dbSNP
rs1477237436 1041 dbSNP
rs935220638 1052 dbSNP
rs1431296673 1060 dbSNP
rs1333192577 1065 dbSNP
rs562317357 1067 dbSNP
rs923842541 1069 dbSNP
rs1187044347 1070 dbSNP
rs141953869 1085 dbSNP
rs1290910039 1088 dbSNP
rs1040924918 1089 dbSNP
rs943849877 1093 dbSNP
rs1326205058 1102 dbSNP
rs1006605504 1110 dbSNP
rs773222114 1113 dbSNP
rs889642252 1123 dbSNP
rs765353360 1137 dbSNP
rs532057494 1139 dbSNP
rs1217468885 1143 dbSNP
rs1211351431 1147 dbSNP
rs868455296 1151 dbSNP
rs920569858 1159 dbSNP
rs1272474900 1163 dbSNP
rs973695386 1173 dbSNP
rs1430802518 1188 dbSNP
rs902412194 1190 dbSNP
rs1171990643 1200 dbSNP
rs1042428923 1206 dbSNP
rs1402185910 1208 dbSNP
rs510770 1211 dbSNP
rs187716422 1217 dbSNP
rs140044329 1223 dbSNP
rs1303825781 1225 dbSNP
rs1347539924 1226 dbSNP
rs553022711 1241 dbSNP
rs928151509 1242 dbSNP
rs1225789746 1254 dbSNP
rs1284327908 1255 dbSNP
rs1352448104 1258 dbSNP
rs540772760 1262 dbSNP
rs1023349395 1272 dbSNP
rs144238110 1275 dbSNP
rs776684165 1284 dbSNP
rs893490645 1291 dbSNP
rs555178041 1292 dbSNP
rs1471123759 1300 dbSNP
rs536915578 1306 dbSNP
rs999183731 1307 dbSNP
rs73441811 1322 dbSNP
rs1164494691 1326 dbSNP
rs1471901010 1334 dbSNP
rs1392941161 1338 dbSNP
rs1040975716 1339 dbSNP
rs1323004943 1339 dbSNP
rs696717 1341 dbSNP
rs1188387748 1342 dbSNP
rs1307513070 1346 dbSNP
rs1029523846 1347 dbSNP
rs1246213152 1355 dbSNP
rs1472165730 1355 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site CDS
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gacacccucccguCACCACUCUc 5'
                       ||||||||| 
Target 5' ----------aatGTGGTGAGAa 3'
 		1 - 13
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.654 2.6e-4 -0.365 4.0e-2 24 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.395 1.5e-1 0.100 4.0e-1 9 Click to see details
GSE32688 Pancreatic cancer -0.191 1.5e-1 -0.227 1.1e-1 32 Click to see details
GSE19783 ER+ ER+ breast cancer -0.246 1.5e-1 -0.218 1.8e-1 20 Click to see details
GSE14794 Lymphoblastoid cells -0.105 1.6e-1 -0.025 4.1e-1 90 Click to see details
GSE21687 Ependynoma primary tumors -0.122 1.7e-1 -0.131 1.5e-1 64 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.177 2.0e-1 -0.145 2.4e-1 25 Click to see details
GSE28260 Renal cortex and medulla 0.183 2.7e-1 0.143 3.2e-1 13 Click to see details
GSE17498 Multiple myeloma -0.097 2.8e-1 -0.124 2.2e-1 40 Click to see details
GSE19536 Breast cancer -0.048 3.2e-1 -0.055 2.9e-1 100 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.074 3.6e-1 0.047 4.1e-1 25 Click to see details
GSE21032 Prostate cancer 0.029 4.0e-1 0.068 2.7e-1 83 Click to see details
GSE19350 CNS germ cell tumors 0.067 4.2e-1 -0.026 4.7e-1 12 Click to see details
GSE19783 ER- ER- breast cancer -0.023 4.2e-1 -0.035 3.8e-1 79 Click to see details
GSE26953 Aortic valvular endothelial cells -0.028 4.5e-1 -0.153 2.4e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.009 4.8e-1 -0.296 1.0e-1 20 Click to see details
GSE38226 Liver fibrosis -0.006 4.9e-1 -0.198 1.9e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUAD -0.935 0.03 -1.000 0.5 4 Click to see details
KIRC -0.17 0.12 -0.246 0.04 51 Click to see details
BRCA -0.156 0.16 -0.150 0.17 42 Click to see details
KIRP -0.204 0.17 -0.224 0.15 24 Click to see details
PAAD -0.653 0.17 -0.800 0.1 4 Click to see details
LUSC 0.211 0.18 0.427 0.03 21 Click to see details
LIHC -0.106 0.29 0.106 0.29 30 Click to see details
UCEC -0.206 0.3 -0.100 0.4 9 Click to see details
STAD 0.142 0.3 0.089 0.37 16 Click to see details
HNSC 0.176 0.31 0.261 0.23 10 Click to see details
CHOL 0.151 0.42 0.400 0.3 4 Click to see details
BLCA 0.088 0.43 0.371 0.23 6 Click to see details
THCA -0.022 0.45 0.307 0.04 34 Click to see details
PRAD -0.012 0.49 0.500 0.2 5 Click to see details
KICH -0.004 0.49 -0.044 0.44 13 Click to see details
KICH -0.004 0.49 -0.044 0.44 13 Click to see details
KICH -0.004 0.49 -0.044 0.44 13 Click to see details
KICH -0.004 0.49 -0.044 0.44 13 Click to see details
KICH -0.004 0.49 -0.044 0.44 13 Click to see details
KICH -0.004 0.49 -0.044 0.44 13 Click to see details
KICH -0.004 0.49 -0.044 0.44 13 Click to see details
196 hsa-miR-1229-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT036258 VWA8 von Willebrand factor A domain containing 8 1 1
MIRT036259 SORBS3 sorbin and SH3 domain containing 3 1 1
MIRT036260 HIST1H3A histone cluster 1 H3 family member a 1 1
MIRT036261 TIA1 TIA1 cytotoxic granule associated RNA binding protein 1 1
MIRT036262 COIL coilin 1 1
MIRT036263 PBRM1 polybromo 1 1 1
MIRT036264 KRT28 keratin 28 1 1
MIRT036265 RPL7A ribosomal protein L7a 1 1
MIRT036266 EEF2 eukaryotic translation elongation factor 2 1 1
MIRT036267 CEP152 centrosomal protein 152 1 1
MIRT036268 CPT1B carnitine palmitoyltransferase 1B 1 1
MIRT036269 CEP55 centrosomal protein 55 1 1
MIRT036270 ZMYM2 zinc finger MYM-type containing 2 1 1
MIRT036271 CRISP3 cysteine rich secretory protein 3 1 1
MIRT036272 CDKN1A cyclin dependent kinase inhibitor 1A 1 1
MIRT036273 ADPRHL2 ADP-ribosylhydrolase like 2 1 1
MIRT036274 PHRF1 PHD and ring finger domains 1 1 1
MIRT036275 RPL3 ribosomal protein L3 1 1
MIRT036276 CSDE1 cold shock domain containing E1 1 1
MIRT036277 PTPRF protein tyrosine phosphatase, receptor type F 1 1
MIRT036278 ZNF264 zinc finger protein 264 1 1
MIRT036279 AHCYL1 adenosylhomocysteinase like 1 1 1
MIRT036280 GAPDH glyceraldehyde-3-phosphate dehydrogenase 1 1
MIRT036281 INTS10 integrator complex subunit 10 1 1
MIRT036282 TARDBP TAR DNA binding protein 1 1
MIRT036283 CTNND1 catenin delta 1 1 1
MIRT036284 KCTD15 potassium channel tetramerization domain containing 15 1 1
MIRT036285 CEP350 centrosomal protein 350 1 1
MIRT036286 C19orf10 myeloid derived growth factor 1 1
MIRT036287 TNRC6B trinucleotide repeat containing 6B 1 1
MIRT036288 CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 1 1
MIRT036289 POLR2D RNA polymerase II subunit D 1 1
MIRT036290 PHC1 polyhomeotic homolog 1 1 1
MIRT036291 HNRNPD heterogeneous nuclear ribonucleoprotein D 1 1
MIRT036292 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 1 1
MIRT036293 AIF1L allograft inflammatory factor 1 like 1 1
MIRT036294 NEU3 neuraminidase 3 1 1
MIRT036295 DCTD dCMP deaminase 1 1
MIRT036296 TUBA1B tubulin alpha 1b 1 1
MIRT036297 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 1 1
MIRT036298 ACOT7 acyl-CoA thioesterase 7 1 1
MIRT036299 MDK midkine 1 1
MIRT036300 INO80D INO80 complex subunit D 1 1
MIRT036301 LDOC1L retrotransposon Gag like 6 1 1
MIRT036302 C2orf44 WD repeat and coiled coil containing 1 1
MIRT036303 SRCAP Snf2 related CREBBP activator protein 1 1
MIRT036304 EPB41L2 erythrocyte membrane protein band 4.1 like 2 1 1
MIRT036305 REXO2 RNA exonuclease 2 1 1
MIRT036306 CTNNBL1 catenin beta like 1 1 1
MIRT036307 SAFB scaffold attachment factor B 1 1
MIRT036308 PPP6R1 protein phosphatase 6 regulatory subunit 1 1 1
MIRT036309 FEN1 flap structure-specific endonuclease 1 1 1
MIRT036310 LRBA LPS responsive beige-like anchor protein 1 1
MIRT036311 SCAMP5 secretory carrier membrane protein 5 1 1
MIRT036312 DAG1 dystroglycan 1 1 1
MIRT036313 HYPK huntingtin interacting protein K 1 1
MIRT036314 HIST1H4C histone cluster 1 H4 family member c 1 1
MIRT036315 CDC42EP4 CDC42 effector protein 4 1 1
MIRT036316 ERC1 ELKS/RAB6-interacting/CAST family member 1 1 1
MIRT036317 GTF2I general transcription factor IIi 1 1
MIRT036318 RPGRIP1L RPGRIP1 like 1 1
MIRT036319 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 1 1
MIRT036320 TRRAP transformation/transcription domain associated protein 1 1
MIRT036321 PHF8 PHD finger protein 8 1 1
MIRT036322 TSC22D3 TSC22 domain family member 3 1 1
MIRT036323 MPP2 membrane palmitoylated protein 2 1 1
MIRT036324 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 1 1
MIRT036325 ALS2 ALS2, alsin Rho guanine nucleotide exchange factor 1 1
MIRT036326 KMT2D lysine methyltransferase 2D 1 1
MIRT036327 ITGA5 integrin subunit alpha 5 1 1
MIRT036328 ABCC5 ATP binding cassette subfamily C member 5 1 1
MIRT036329 KIF24 kinesin family member 24 1 1
MIRT036330 PPP4C protein phosphatase 4 catalytic subunit 1 1
MIRT036331 FMNL2 formin like 2 1 1
MIRT036332 NF2 neurofibromin 2 1 1
MIRT036333 NUP210 nucleoporin 210 1 1
MIRT036334 CTDNEP1 CTD nuclear envelope phosphatase 1 1 1
MIRT036335 EIF4G2 eukaryotic translation initiation factor 4 gamma 2 1 1
MIRT036336 CTCF CCCTC-binding factor 1 1
MIRT036337 LRIT1 leucine rich repeat, Ig-like and transmembrane domains 1 1 1
MIRT036338 SFPQ splicing factor proline and glutamine rich 1 1
MIRT036339 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1 1
MIRT036340 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 1 1
MIRT036341 SLC39A7 solute carrier family 39 member 7 1 1
MIRT036342 KDM5C lysine demethylase 5C 1 1
MIRT036343 ACLY ATP citrate lyase 1 1
MIRT036344 MED19 mediator complex subunit 19 1 1
MIRT036345 SRP72 signal recognition particle 72 1 1
MIRT036346 RUVBL2 RuvB like AAA ATPase 2 1 1
MIRT036347 CLSTN3 calsyntenin 3 1 1
MIRT036348 SAE1 SUMO1 activating enzyme subunit 1 1 1
MIRT036349 TUBG1 tubulin gamma 1 1 1
MIRT036350 FOXP1 forkhead box P1 1 1
MIRT036351 ZNF687 zinc finger protein 687 1 1
MIRT036352 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 1 1
MIRT036353 HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 1 1
MIRT036354 RNF40 ring finger protein 40 1 1
MIRT036355 KPNB1 karyopherin subunit beta 1 1 1
MIRT036356 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 1 1
MIRT036357 DDX23 DEAD-box helicase 23 1 1
MIRT036358 BET1L Bet1 golgi vesicular membrane trafficking protein like 1 1
MIRT036359 BRD2 bromodomain containing 2 1 1
MIRT036360 EML1 echinoderm microtubule associated protein like 1 1 1
MIRT036361 BAP1 BRCA1 associated protein 1 1 1
MIRT036362 STAT5B signal transducer and activator of transcription 5B 1 1
MIRT036363 SUPT5H SPT5 homolog, DSIF elongation factor subunit 1 1
MIRT036364 GPI glucose-6-phosphate isomerase 1 1
MIRT036365 PTBP3 polypyrimidine tract binding protein 3 1 1
MIRT036366 RPS15 ribosomal protein S15 1 1
MIRT036367 ZDHHC7 zinc finger DHHC-type containing 7 1 1
MIRT036368 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 1 1
MIRT036369 SNX12 sorting nexin 12 1 1
MIRT036370 OTUD7B OTU deubiquitinase 7B 1 1
MIRT036371 AP2M1 adaptor related protein complex 2 mu 1 subunit 1 1
MIRT036372 C9orf114 SPOUT domain containing methyltransferase 1 1 1
MIRT036373 MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 1 1
MIRT036374 FOXK1 forkhead box K1 1 1
MIRT036375 SIK2 salt inducible kinase 2 1 1
MIRT036376 SCD stearoyl-CoA desaturase 1 1
MIRT036377 PHGDH phosphoglycerate dehydrogenase 1 1
MIRT036378 PITPNB phosphatidylinositol transfer protein beta 1 1
MIRT036379 MAD2L2 mitotic arrest deficient 2 like 2 1 1
MIRT036380 TUSC3 tumor suppressor candidate 3 1 1
MIRT036381 PRKRIP1 PRKR interacting protein 1 1 1
MIRT036382 DCAF7 DDB1 and CUL4 associated factor 7 1 1
MIRT036383 NME2 NME/NM23 nucleoside diphosphate kinase 2 1 1
MIRT036384 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 1 1
MIRT036385 SLC16A13 solute carrier family 16 member 13 1 1
MIRT036386 PRDX4 peroxiredoxin 4 1 1
MIRT036387 NXPE3 neurexophilin and PC-esterase domain family member 3 1 1
MIRT036388 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 1 1
MIRT036389 CPNE1 copine 1 1 1
MIRT036390 PSMC5 proteasome 26S subunit, ATPase 5 1 1
MIRT036391 PAK4 p21 (RAC1) activated kinase 4 1 1
MIRT059262 CELF1 CUGBP Elav-like family member 1 2 2
MIRT061283 IPO7 importin 7 2 2
MIRT080097 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT345981 BIRC5 baculoviral IAP repeat containing 5 2 8
MIRT366471 KLHL15 kelch like family member 15 2 2
MIRT379534 HNRNPK heterogeneous nuclear ribonucleoprotein K 2 2
MIRT443697 HUNK hormonally up-regulated Neu-associated kinase 2 4
MIRT472347 NETO2 neuropilin and tolloid like 2 2 2
MIRT497842 GATA6 GATA binding protein 6 2 4
MIRT510408 ZNF268 zinc finger protein 268 2 4
MIRT519621 ZNF781 zinc finger protein 781 2 2
MIRT519830 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT530712 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT530802 GPR182 G protein-coupled receptor 182 2 2
MIRT534374 SETD7 SET domain containing lysine methyltransferase 7 2 2
MIRT535541 P2RY2 purinergic receptor P2Y2 2 2
MIRT536016 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT556019 MYBL1 MYB proto-oncogene like 1 2 2
MIRT560009 ZNF525 zinc finger protein 525 2 2
MIRT560072 ZNF195 zinc finger protein 195 2 2
MIRT565948 RRAGD Ras related GTP binding D 2 2
MIRT570131 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT570887 ZNF780A zinc finger protein 780A 2 4
MIRT609775 VWC2L von Willebrand factor C domain containing protein 2 like 2 4
MIRT611445 NRIP3 nuclear receptor interacting protein 3 2 2
MIRT611975 ZNF175 zinc finger protein 175 2 2
MIRT612871 IGFBP5 insulin like growth factor binding protein 5 2 4
MIRT613012 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT617515 PTDSS1 phosphatidylserine synthase 1 2 2
MIRT636095 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT637442 ZNF324B zinc finger protein 324B 2 2
MIRT638303 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT638920 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT640590 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT646760 WDR3 WD repeat domain 3 2 2
MIRT652591 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654866 PPL periplakin 2 2
MIRT654952 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT656021 MYO5B myosin VB 2 2
MIRT657078 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657880 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT659231 CXCR5 C-X-C motif chemokine receptor 5 2 2
MIRT662904 MED18 mediator complex subunit 18 2 2
MIRT685610 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT687424 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT692293 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT693749 ZNF383 zinc finger protein 383 2 2
MIRT695121 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695138 PRY PTPN13-like, Y-linked 2 2
MIRT709581 LETMD1 LETM1 domain containing 1 2 2
MIRT709737 TRIM27 tripartite motif containing 27 2 2
MIRT711058 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT714189 TRAF7 TNF receptor associated factor 7 2 2
MIRT715924 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT719463 SRF serum response factor 2 2
MIRT720172 PANK2 pantothenate kinase 2 2 2
MIRT720456 RAB31 RAB31, member RAS oncogene family 2 2
MIRT721642 ZNF207 zinc finger protein 207 2 2
MIRT721996 CLLU1OS chronic lymphocytic leukemia up-regulated 1 opposite strand 2 2
MIRT722187 DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 2 2
MIRT725196 PTRF caveolae associated protein 1 2 2
MIRT725518 FAM229B family with sequence similarity 229 member B 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1229 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 down-regulated
miR-1229 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1229 Goserelin approved 47725 Microarray prostate 22674191 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1229 Fluorouracil 3385 NSC19893 approved sensitive cell line (KYSE)
hsa-miR-1229-3p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-1229-3p Doxorubicin 31703 NSC123127 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-1229-3p Fluorouracil 3385 NSC19893 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-1229-3p Vincristine 5978 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-1229-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-1229-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-1229-3p Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma cell line (Huh-7, PLC)
hsa-miR-1229-3p Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-1229-3p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-1229-3p Fluorouracil 3385 NSC19893 approved resistant Low Gastric Cancer cell line (HGC-27, GFP-MKN45)
hsa-miR-1229-3p Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma cell line (Huh-7, PLC)
hsa-miR-1229-3p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-1229-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-1229-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-1229-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-1229-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1229-3p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-1229-3p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-1229-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1229-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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