miRTarBase - #MIRT036272


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pre-miRNA Information
pre-miRNA hsa-mir-1229   
Genomic Coordinates chr5: 179798278 - 179798346
Synonyms MIRN1229, hsa-mir-1229, MIR1229
Description Homo sapiens miR-1229 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-1229-3p
Sequence 47| CUCUCACCACUGCCCUCCCACAG |69
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN20086841 1 COSMIC
COSN16303113 8 COSMIC
COSM6273761 14 COSMIC
COSM1066702 23 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs754734738 1 dbSNP
rs1479021409 8 dbSNP
rs200647784 9 dbSNP
rs1429872559 12 dbSNP
rs1373546432 13 dbSNP
rs766644214 15 dbSNP
rs758465824 18 dbSNP
rs1396376879 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CDKN1A   
Synonyms CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
Description cyclin dependent kinase inhibitor 1A
Transcript NM_000389   
Other Transcripts NM_078467   
Expression
Putative miRNA Targets on CDKN1A
3'UTR of CDKN1A
(miRNA target sites are highlighted)		 
>CDKN1A|NM_000389|3'UTR
   1 TCCGCCCACAGGAAGCCTGCAGTCCTGGAAGCGCGAGGGCCTCAAAGGCCCGCTCTACATCTTCTGCCTTAGTCTCAGTT
  81 TGTGTGTCTTAATTATTATTTGTGTTTTAATTTAAACACCTCCTCATGTACATACCCTGGCCGCCCCCTGCCCCCCAGCC
 161 TCTGGCATTAGAATTATTTAAACAAAAACTAGGCGGTTGAATGAGAGGTTCCTAAGAGTGCTGGGCATTTTTATTTTATG
 241 AAATACTATTTAAAGCCTCCTCATCCCGTGTTCTCCTTTTCCTCTCTCCCGGAGGTTGGGTGGGCCGGCTTCATGCCAGC
 321 TACTTCCTCCTCCCCACTTGTCCGCTGGGTGGTACCCTCTGGAGGGGTGTGGCTCCTTCCCATCGCTGTCACAGGCGGTT
 401 ATGAAATTCACCCCCTTTCCTGGACACTCAGACCTGAATTCTTTTTCATTTGAGAAGTAAACAGATGGCACTTTGAAGGG
 481 GCCTCACCGAGTGGGGGCATCATCAAAAACTTTGGAGTCCCCTCACCTCCTCTAAGGTTGGGCAGGGTGACCCTGAAGTG
 561 AGCACAGCCTAGGGCTGAGCTGGGGACCTGGTACCCTCCTGGCTCTTGATACCCCCCTCTGTCTTGTGAAGGCAGGGGGA
 641 AGGTGGGGTCCTGGAGCAGACCACCCCGCCTGCCCTCATGGCCCCTCTGACCTGCACTGGGGAGCCCGTCTCAGTGTTGA
 721 GCCTTTTCCCTCTTTGGCTCCCCTGTACCTTTTGAGGAGCCCCAGCTACCCTTCTTCTCCAGCTGGGCTCTGCAATTCCC
 801 CTCTGCTGCTGTCCCTCCCCCTTGTCCTTTCCCTTCAGTACCCTCTCAGCTCCAGGTGGCTCTGAGGTGCCTGTCCCACC
 881 CCCACCCCCAGCTCAATGGACTGGAAGGGGAAGGGACACACAAGAAGAAGGGCACCCTAGTTCTACCTCAGGCAGCTCAA
 961 GCAGCGACCGCCCCCTCCTCTAGCTGTGGGGGTGAGGGTCCCATGTGGTGGCACAGGCCCCCTTGAGTGGGGTTATCTCT
1041 GTGTTAGGGGTATATGATGGGGGAGTAGATCTTTCTAGGAGGGAGACACTGGCCCCTCAAATCGTCCAGCGACCTTCCTC
1121 ATCCACCCCATCCCTCCCCAGTTCATTGCACTTTGATTAGCAGCGGAACAAGGAGTCAGACATTTTAAGATGGTGGCAGT
1201 AGAGGCTATGGACAGGGCATGCCACGTGGGCTCATATGGGGCTGGGAGTAGTTGTCTTTCCTGGCACTAACGTTGAGCCC
1281 CTGGAGGCACTGAAGTGCTTAGTGTACTTGGAGTATTGGGGTCTGACCCCAAACACCTTCCAGCTCCTGTAACATACTGG
1361 CCTGGACTGTTTTCTCTCGGCTCCCCATGTGTCCTGGTTCCCGTTTCTCCACCTAGACTGTAAACCTCTCGAGGGCAGGG
1441 ACCACACCCTGTACTGTTCTGTGTCTTTCACAGCTCCTCCCACAATGCTGAATATACAGCAGGTGCTCAATAAATGATTC
1521 TTAGTGACTTTACTTGTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacacccuccCGUCACCACUCUc 5'
                    |::| ||||||: 
Target 5' tcctctagctGTGGGGGTGAGGg 3'
 976 - 998 133.00 -23.90
2 
miRNA  3' gacACCCUCCCGUC-----ACCACUCUc 5'
             || || |||||      ||||:|: 
Target 5' tctTGTGAAGGCAGGGGGAAGGTGGGGt 3'
 622 - 649 128.00 -21.40
3 
miRNA  3' gacaCCCUCCCGUCACCACUcuc 5'
              ||  |||||| |||||   
Target 5' ctaaGGTTGGGCAG-GGTGAccc 3'
 532 - 553 126.00 -20.82
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN8871647 4 COSMIC
COSN30107428 13 COSMIC
COSN17136499 21 COSMIC
COSN24388178 36 COSMIC
COSN30512604 38 COSMIC
COSN26970192 40 COSMIC
COSN30166588 65 COSMIC
COSN24301745 80 COSMIC
COSN30488608 90 COSMIC
COSN30469357 137 COSMIC
COSN30533369 148 COSMIC
COSN32056942 195 COSMIC
COSN17181950 363 COSMIC
COSN21122568 516 COSMIC
COSN8514252 516 COSMIC
COSN20590362 520 COSMIC
COSN26644634 575 COSMIC
COSN32057748 625 COSMIC
COSN31576773 708 COSMIC
COSN15779126 787 COSMIC
COSN28791109 848 COSMIC
COSN8514253 848 COSMIC
COSN26566755 989 COSMIC
COSN31541982 1111 COSMIC
COSN31595516 1138 COSMIC
COSN9781735 1206 COSMIC
COSN21510222 1432 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs139304346 4 dbSNP
rs747014318 5 dbSNP
rs1184573689 9 dbSNP
rs1396765368 11 dbSNP
rs1445659229 11 dbSNP
rs777207887 12 dbSNP
rs1376040331 15 dbSNP
rs1226999329 17 dbSNP
rs1059234 21 dbSNP
rs770267002 22 dbSNP
rs775069456 23 dbSNP
rs945802868 24 dbSNP
rs1475096701 28 dbSNP
rs762632530 29 dbSNP
rs201408395 32 dbSNP
rs375173291 33 dbSNP
rs41272170 34 dbSNP
rs1482370511 35 dbSNP
rs150869821 36 dbSNP
rs3176357 39 dbSNP
rs754567385 40 dbSNP
rs1166992411 41 dbSNP
rs755968076 44 dbSNP
rs1423988118 48 dbSNP
rs111926164 52 dbSNP
rs575815855 53 dbSNP
rs998171288 56 dbSNP
rs1028124783 57 dbSNP
rs952159534 59 dbSNP
rs983400213 67 dbSNP
rs907923458 69 dbSNP
rs760541872 75 dbSNP
rs1428687704 80 dbSNP
rs976707693 105 dbSNP
rs1451995360 114 dbSNP
rs951389423 117 dbSNP
rs763632708 118 dbSNP
rs1394250512 125 dbSNP
rs1322653551 126 dbSNP
rs779826646 133 dbSNP
rs922225207 136 dbSNP
rs187742871 137 dbSNP
rs914304254 138 dbSNP
rs1443635232 139 dbSNP
rs564494785 143 dbSNP
rs112675295 144 dbSNP
rs1041396487 145 dbSNP
rs1317251949 152 dbSNP
rs1210788045 155 dbSNP
rs1489707452 157 dbSNP
rs866686724 158 dbSNP
rs1245438449 163 dbSNP
rs1343160898 179 dbSNP
rs546659289 182 dbSNP
rs756718995 195 dbSNP
rs191431994 196 dbSNP
rs529170426 208 dbSNP
rs755706954 209 dbSNP
rs1056094900 222 dbSNP
rs960959039 226 dbSNP
rs1301078579 240 dbSNP
rs1423551932 245 dbSNP
rs1370821103 248 dbSNP
rs543585485 249 dbSNP
rs114982296 258 dbSNP
rs778242620 260 dbSNP
rs781689614 268 dbSNP
rs1372999209 283 dbSNP
rs41272172 284 dbSNP
rs1043234187 287 dbSNP
rs1483485414 291 dbSNP
rs925724850 291 dbSNP
rs1277091698 292 dbSNP
rs796185918 297 dbSNP
rs184374036 305 dbSNP
rs1039501629 307 dbSNP
rs1275518074 308 dbSNP
rs1387758636 311 dbSNP
rs539152524 313 dbSNP
rs1233808733 315 dbSNP
rs1347344575 321 dbSNP
rs866398753 327 dbSNP
rs189270770 330 dbSNP
rs566360271 333 dbSNP
rs1370764937 336 dbSNP
rs1046926038 344 dbSNP
rs1374607192 345 dbSNP
rs1407714364 352 dbSNP
rs377595930 355 dbSNP
rs887116254 358 dbSNP
rs181350370 377 dbSNP
rs1017456404 381 dbSNP
rs1302198995 385 dbSNP
rs3176358 386 dbSNP
rs1002260135 397 dbSNP
rs373590939 397 dbSNP
rs1454501485 398 dbSNP
rs1338842504 412 dbSNP
rs1363084136 416 dbSNP
rs866383890 416 dbSNP
rs976121091 430 dbSNP
rs1179838684 434 dbSNP
rs1296509107 440 dbSNP
rs575126168 442 dbSNP
rs1035203096 443 dbSNP
rs535732427 444 dbSNP
rs1309634071 451 dbSNP
rs960823517 458 dbSNP
rs922162572 467 dbSNP
rs1261233743 476 dbSNP
rs953675606 478 dbSNP
rs532581570 482 dbSNP
rs1281079083 488 dbSNP
rs777824384 489 dbSNP
rs879879447 493 dbSNP
rs1245700146 494 dbSNP
rs749588003 497 dbSNP
rs879309299 498 dbSNP
rs1176417316 499 dbSNP
rs1458233139 501 dbSNP
rs1410545818 513 dbSNP
rs557591236 514 dbSNP
rs1469781325 526 dbSNP
rs1238310449 527 dbSNP
rs914777007 529 dbSNP
rs978433655 530 dbSNP
rs1439329339 532 dbSNP
rs925725564 533 dbSNP
rs942480428 537 dbSNP
rs1039405016 541 dbSNP
rs575878563 545 dbSNP
rs1186756151 547 dbSNP
rs572991639 548 dbSNP
rs1241195720 553 dbSNP
rs946204604 587 dbSNP
rs1431092774 592 dbSNP
rs541799707 606 dbSNP
rs1286032990 612 dbSNP
rs1221894791 613 dbSNP
rs922442057 615 dbSNP
rs933792625 616 dbSNP
rs546335483 618 dbSNP
rs1047001332 625 dbSNP
rs1055493853 632 dbSNP
rs894366694 638 dbSNP
rs367706888 640 dbSNP
rs995702977 642 dbSNP
rs1316639627 646 dbSNP
rs1400543397 648 dbSNP
rs1414782201 651 dbSNP
rs184742749 655 dbSNP
rs941387040 656 dbSNP
rs1048397424 664 dbSNP
rs370572240 665 dbSNP
rs189202045 668 dbSNP
rs757862523 669 dbSNP
rs1289515919 683 dbSNP
rs540666701 692 dbSNP
rs1213364316 693 dbSNP
rs1446277683 700 dbSNP
rs1292232768 702 dbSNP
rs1247641087 708 dbSNP
rs774512258 709 dbSNP
rs1364417768 711 dbSNP
rs1004007357 717 dbSNP
rs1268992201 723 dbSNP
rs1014932119 733 dbSNP
rs1350764432 737 dbSNP
rs1305357860 741 dbSNP
rs1002289641 742 dbSNP
rs1365225649 743 dbSNP
rs1346497851 750 dbSNP
rs1225909893 754 dbSNP
rs1035067351 755 dbSNP
rs1169270853 760 dbSNP
rs997905489 770 dbSNP
rs1266718439 772 dbSNP
rs6457937 775 dbSNP
rs1269272527 778 dbSNP
rs529198430 781 dbSNP
rs990366166 796 dbSNP
rs544057426 812 dbSNP
rs1009737725 815 dbSNP
rs1021650885 821 dbSNP
rs968318210 822 dbSNP
rs1292832469 834 dbSNP
rs562367477 841 dbSNP
rs1214437185 843 dbSNP
rs139090547 846 dbSNP
rs967514962 851 dbSNP
rs980065929 853 dbSNP
rs1345101601 858 dbSNP
rs181534480 870 dbSNP
rs551145694 874 dbSNP
rs566590564 877 dbSNP
rs186592256 880 dbSNP
rs10046116 885 dbSNP
rs548971366 897 dbSNP
rs1401216744 907 dbSNP
rs567103693 914 dbSNP
rs772094412 918 dbSNP
rs991560468 919 dbSNP
rs1479367670 922 dbSNP
rs933848673 943 dbSNP
rs74801436 948 dbSNP
rs908342499 966 dbSNP
rs557652835 970 dbSNP
rs1203248566 971 dbSNP
rs1324860987 972 dbSNP
rs1265599057 987 dbSNP
rs1346545037 991 dbSNP
rs1323184962 998 dbSNP
rs1308173710 1008 dbSNP
rs1393307997 1013 dbSNP
rs1059247 1023 dbSNP
rs1486210553 1028 dbSNP
rs191000568 1031 dbSNP
rs1286834345 1032 dbSNP
rs1448911279 1043 dbSNP
rs1038653449 1049 dbSNP
rs1178582184 1050 dbSNP
rs375384268 1051 dbSNP
rs939842159 1055 dbSNP
rs1373329428 1061 dbSNP
rs1040878666 1067 dbSNP
rs540064877 1071 dbSNP
rs1258434302 1089 dbSNP
rs1308574600 1104 dbSNP
rs937985105 1105 dbSNP
rs776135188 1111 dbSNP
rs558063177 1112 dbSNP
rs889082589 1115 dbSNP
rs1261637880 1119 dbSNP
rs1011602474 1121 dbSNP
rs1315327520 1122 dbSNP
rs1306631788 1135 dbSNP
rs761473919 1142 dbSNP
rs1385000901 1148 dbSNP
rs1232064352 1152 dbSNP
rs1450298684 1161 dbSNP
rs573326094 1165 dbSNP
rs3176359 1166 dbSNP
rs903998141 1177 dbSNP
rs960052426 1184 dbSNP
rs1157825566 1190 dbSNP
rs555737213 1191 dbSNP
rs1386505260 1206 dbSNP
rs1181247844 1207 dbSNP
rs1461236031 1210 dbSNP
rs749899530 1213 dbSNP
rs1263105800 1224 dbSNP
rs1207246532 1226 dbSNP
rs573926464 1227 dbSNP
rs1223431084 1228 dbSNP
rs544119216 1234 dbSNP
rs1163000989 1236 dbSNP
rs930958513 1238 dbSNP
rs983778153 1243 dbSNP
rs1296287341 1251 dbSNP
rs1802569 1257 dbSNP
rs1383705783 1265 dbSNP
rs1382434582 1266 dbSNP
rs1297375941 1267 dbSNP
rs1424855287 1270 dbSNP
rs1426782231 1272 dbSNP
rs908447221 1273 dbSNP
rs1161106457 1277 dbSNP
rs1443541621 1279 dbSNP
rs1306606588 1281 dbSNP
rs1802570 1296 dbSNP
rs182235412 1299 dbSNP
rs185976780 1300 dbSNP
rs544851636 1304 dbSNP
rs1261412400 1309 dbSNP
rs1200644254 1311 dbSNP
rs1490893779 1314 dbSNP
rs1300371776 1319 dbSNP
rs1376345118 1321 dbSNP
rs1340234208 1328 dbSNP
rs1244523840 1350 dbSNP
rs963715824 1361 dbSNP
rs1324648171 1365 dbSNP
rs1277296198 1375 dbSNP
rs745953295 1380 dbSNP
rs1361208671 1382 dbSNP
rs932480638 1386 dbSNP
rs11550973 1388 dbSNP
rs527383432 1389 dbSNP
rs1396519804 1390 dbSNP
rs1169167214 1392 dbSNP
rs548775480 1394 dbSNP
rs1011571683 1397 dbSNP
rs1423597658 1398 dbSNP
rs73730143 1403 dbSNP
rs903433616 1404 dbSNP
rs982916069 1416 dbSNP
rs1267037831 1426 dbSNP
rs531369735 1431 dbSNP
rs778257166 1432 dbSNP
rs1194188901 1434 dbSNP
rs1183138065 1440 dbSNP
rs1337340457 1441 dbSNP
rs1257405417 1445 dbSNP
rs1223890425 1449 dbSNP
rs1036363838 1452 dbSNP
rs1385906506 1460 dbSNP
rs766360274 1460 dbSNP
rs1446722024 1461 dbSNP
rs1166317774 1462 dbSNP
rs564442732 1473 dbSNP
rs1419284609 1477 dbSNP
rs941154808 1479 dbSNP
rs1136646 1483 dbSNP
rs1471247583 1499 dbSNP
rs1427573585 1509 dbSNP
rs549777937 1512 dbSNP
rs1470615589 1515 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gacacccucccgucaccACUCUc 5'
                           ||||| 
Target 5' ---actaggcggttgaaTGAGAg 3'
 		1 - 20
2 
miRNA  3' gacACCCUCCCG------UCACCACUC-UC-- 5'
             || |||| :      |||| ||:| |   
Target 5' gaaTGAGAGGTTCCTAAGAGTGCTGGGCATTT 3'
 		12 - 43
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE19536 Breast cancer 0.182 3.5e-2 0.222 1.3e-2 100 Click to see details
GSE19783 ER+ ER+ breast cancer 0.377 5.1e-2 0.388 4.5e-2 20 Click to see details
GSE14794 Lymphoblastoid cells 0.163 6.2e-2 0.126 1.2e-1 90 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.348 6.6e-2 -0.386 4.6e-2 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.293 7.8e-2 -0.295 7.6e-2 25 Click to see details
GSE19783 ER- ER- breast cancer 0.149 9.5e-2 0.196 4.2e-2 79 Click to see details
GSE26953 Aortic valvular endothelial cells 0.241 1.3e-1 0.525 4.2e-3 24 Click to see details
GSE38226 Liver fibrosis 0.222 1.7e-1 0.229 1.6e-1 21 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.32 2.0e-1 -0.467 1.0e-1 9 Click to see details
GSE21687 Ependynoma primary tumors -0.104 2.1e-1 -0.068 3.0e-1 64 Click to see details
GSE28544 Breast cancer 0.151 2.4e-1 -0.035 4.4e-1 24 Click to see details
GSE28260 Renal cortex and medulla 0.206 2.5e-1 0.016 4.8e-1 13 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.13 2.7e-1 -0.222 1.4e-1 25 Click to see details
GSE42095 Differentiated embryonic stem cells -0.097 3.3e-1 -0.111 3.1e-1 23 Click to see details
GSE17498 Multiple myeloma -0.07 3.3e-1 -0.246 6.3e-2 40 Click to see details
GSE19350 CNS germ cell tumors -0.093 3.9e-1 0.058 4.3e-1 12 Click to see details
GSE21032 Prostate cancer -0.029 4.0e-1 -0.067 2.7e-1 83 Click to see details
GSE32688 Pancreatic cancer -0.034 4.3e-1 -0.080 3.3e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRP -0.352 0.05 -0.298 0.08 24 Click to see details
LUAD -0.886 0.06 -0.800 0.1 4 Click to see details
KIRC -0.191 0.09 -0.235 0.05 51 Click to see details
PAAD -0.815 0.09 -0.400 0.3 4 Click to see details
BLCA -0.512 0.15 -0.314 0.27 6 Click to see details
BRCA 0.164 0.15 0.159 0.16 42 Click to see details
HNSC -0.342 0.17 -0.358 0.15 10 Click to see details
LUSC 0.168 0.23 0.192 0.2 21 Click to see details
UCEC 0.276 0.24 0.233 0.27 9 Click to see details
LIHC 0.117 0.27 0.112 0.28 30 Click to see details
STAD -0.151 0.29 -0.065 0.41 16 Click to see details
KICH 0.163 0.3 0.198 0.26 13 Click to see details
THCA -0.058 0.37 0.069 0.35 34 Click to see details
COAD 0.127 0.44 -0.400 0.3 4 Click to see details
CHOL -0.094 0.45 -0.200 0.4 4 Click to see details
PRAD 0.037 0.48 -0.100 0.44 5 Click to see details
PRAD 0.037 0.48 -0.100 0.44 5 Click to see details
PRAD 0.037 0.48 -0.100 0.44 5 Click to see details
PRAD 0.037 0.48 -0.100 0.44 5 Click to see details
PRAD 0.037 0.48 -0.100 0.44 5 Click to see details
PRAD 0.037 0.48 -0.100 0.44 5 Click to see details
196 hsa-miR-1229-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT036258 VWA8 von Willebrand factor A domain containing 8 1 1
MIRT036259 SORBS3 sorbin and SH3 domain containing 3 1 1
MIRT036260 HIST1H3A histone cluster 1 H3 family member a 1 1
MIRT036261 TIA1 TIA1 cytotoxic granule associated RNA binding protein 1 1
MIRT036262 COIL coilin 1 1
MIRT036263 PBRM1 polybromo 1 1 1
MIRT036264 KRT28 keratin 28 1 1
MIRT036265 RPL7A ribosomal protein L7a 1 1
MIRT036266 EEF2 eukaryotic translation elongation factor 2 1 1
MIRT036267 CEP152 centrosomal protein 152 1 1
MIRT036268 CPT1B carnitine palmitoyltransferase 1B 1 1
MIRT036269 CEP55 centrosomal protein 55 1 1
MIRT036270 ZMYM2 zinc finger MYM-type containing 2 1 1
MIRT036271 CRISP3 cysteine rich secretory protein 3 1 1
MIRT036272 CDKN1A cyclin dependent kinase inhibitor 1A 1 1
MIRT036273 ADPRHL2 ADP-ribosylhydrolase like 2 1 1
MIRT036274 PHRF1 PHD and ring finger domains 1 1 1
MIRT036275 RPL3 ribosomal protein L3 1 1
MIRT036276 CSDE1 cold shock domain containing E1 1 1
MIRT036277 PTPRF protein tyrosine phosphatase, receptor type F 1 1
MIRT036278 ZNF264 zinc finger protein 264 1 1
MIRT036279 AHCYL1 adenosylhomocysteinase like 1 1 1
MIRT036280 GAPDH glyceraldehyde-3-phosphate dehydrogenase 1 1
MIRT036281 INTS10 integrator complex subunit 10 1 1
MIRT036282 TARDBP TAR DNA binding protein 1 1
MIRT036283 CTNND1 catenin delta 1 1 1
MIRT036284 KCTD15 potassium channel tetramerization domain containing 15 1 1
MIRT036285 CEP350 centrosomal protein 350 1 1
MIRT036286 C19orf10 myeloid derived growth factor 1 1
MIRT036287 TNRC6B trinucleotide repeat containing 6B 1 1
MIRT036288 CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 1 1
MIRT036289 POLR2D RNA polymerase II subunit D 1 1
MIRT036290 PHC1 polyhomeotic homolog 1 1 1
MIRT036291 HNRNPD heterogeneous nuclear ribonucleoprotein D 1 1
MIRT036292 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 1 1
MIRT036293 AIF1L allograft inflammatory factor 1 like 1 1
MIRT036294 NEU3 neuraminidase 3 1 1
MIRT036295 DCTD dCMP deaminase 1 1
MIRT036296 TUBA1B tubulin alpha 1b 1 1
MIRT036297 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 1 1
MIRT036298 ACOT7 acyl-CoA thioesterase 7 1 1
MIRT036299 MDK midkine 1 1
MIRT036300 INO80D INO80 complex subunit D 1 1
MIRT036301 LDOC1L retrotransposon Gag like 6 1 1
MIRT036302 C2orf44 WD repeat and coiled coil containing 1 1
MIRT036303 SRCAP Snf2 related CREBBP activator protein 1 1
MIRT036304 EPB41L2 erythrocyte membrane protein band 4.1 like 2 1 1
MIRT036305 REXO2 RNA exonuclease 2 1 1
MIRT036306 CTNNBL1 catenin beta like 1 1 1
MIRT036307 SAFB scaffold attachment factor B 1 1
MIRT036308 PPP6R1 protein phosphatase 6 regulatory subunit 1 1 1
MIRT036309 FEN1 flap structure-specific endonuclease 1 1 1
MIRT036310 LRBA LPS responsive beige-like anchor protein 1 1
MIRT036311 SCAMP5 secretory carrier membrane protein 5 1 1
MIRT036312 DAG1 dystroglycan 1 1 1
MIRT036313 HYPK huntingtin interacting protein K 1 1
MIRT036314 HIST1H4C histone cluster 1 H4 family member c 1 1
MIRT036315 CDC42EP4 CDC42 effector protein 4 1 1
MIRT036316 ERC1 ELKS/RAB6-interacting/CAST family member 1 1 1
MIRT036317 GTF2I general transcription factor IIi 1 1
MIRT036318 RPGRIP1L RPGRIP1 like 1 1
MIRT036319 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 1 1
MIRT036320 TRRAP transformation/transcription domain associated protein 1 1
MIRT036321 PHF8 PHD finger protein 8 1 1
MIRT036322 TSC22D3 TSC22 domain family member 3 1 1
MIRT036323 MPP2 membrane palmitoylated protein 2 1 1
MIRT036324 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 1 1
MIRT036325 ALS2 ALS2, alsin Rho guanine nucleotide exchange factor 1 1
MIRT036326 KMT2D lysine methyltransferase 2D 1 1
MIRT036327 ITGA5 integrin subunit alpha 5 1 1
MIRT036328 ABCC5 ATP binding cassette subfamily C member 5 1 1
MIRT036329 KIF24 kinesin family member 24 1 1
MIRT036330 PPP4C protein phosphatase 4 catalytic subunit 1 1
MIRT036331 FMNL2 formin like 2 1 1
MIRT036332 NF2 neurofibromin 2 1 1
MIRT036333 NUP210 nucleoporin 210 1 1
MIRT036334 CTDNEP1 CTD nuclear envelope phosphatase 1 1 1
MIRT036335 EIF4G2 eukaryotic translation initiation factor 4 gamma 2 1 1
MIRT036336 CTCF CCCTC-binding factor 1 1
MIRT036337 LRIT1 leucine rich repeat, Ig-like and transmembrane domains 1 1 1
MIRT036338 SFPQ splicing factor proline and glutamine rich 1 1
MIRT036339 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1 1
MIRT036340 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 1 1
MIRT036341 SLC39A7 solute carrier family 39 member 7 1 1
MIRT036342 KDM5C lysine demethylase 5C 1 1
MIRT036343 ACLY ATP citrate lyase 1 1
MIRT036344 MED19 mediator complex subunit 19 1 1
MIRT036345 SRP72 signal recognition particle 72 1 1
MIRT036346 RUVBL2 RuvB like AAA ATPase 2 1 1
MIRT036347 CLSTN3 calsyntenin 3 1 1
MIRT036348 SAE1 SUMO1 activating enzyme subunit 1 1 1
MIRT036349 TUBG1 tubulin gamma 1 1 1
MIRT036350 FOXP1 forkhead box P1 1 1
MIRT036351 ZNF687 zinc finger protein 687 1 1
MIRT036352 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 1 1
MIRT036353 HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 1 1
MIRT036354 RNF40 ring finger protein 40 1 1
MIRT036355 KPNB1 karyopherin subunit beta 1 1 1
MIRT036356 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 1 1
MIRT036357 DDX23 DEAD-box helicase 23 1 1
MIRT036358 BET1L Bet1 golgi vesicular membrane trafficking protein like 1 1
MIRT036359 BRD2 bromodomain containing 2 1 1
MIRT036360 EML1 echinoderm microtubule associated protein like 1 1 1
MIRT036361 BAP1 BRCA1 associated protein 1 1 1
MIRT036362 STAT5B signal transducer and activator of transcription 5B 1 1
MIRT036363 SUPT5H SPT5 homolog, DSIF elongation factor subunit 1 1
MIRT036364 GPI glucose-6-phosphate isomerase 1 1
MIRT036365 PTBP3 polypyrimidine tract binding protein 3 1 1
MIRT036366 RPS15 ribosomal protein S15 1 1
MIRT036367 ZDHHC7 zinc finger DHHC-type containing 7 1 1
MIRT036368 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 1 1
MIRT036369 SNX12 sorting nexin 12 1 1
MIRT036370 OTUD7B OTU deubiquitinase 7B 1 1
MIRT036371 AP2M1 adaptor related protein complex 2 mu 1 subunit 1 1
MIRT036372 C9orf114 SPOUT domain containing methyltransferase 1 1 1
MIRT036373 MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 1 1
MIRT036374 FOXK1 forkhead box K1 1 1
MIRT036375 SIK2 salt inducible kinase 2 1 1
MIRT036376 SCD stearoyl-CoA desaturase 1 1
MIRT036377 PHGDH phosphoglycerate dehydrogenase 1 1
MIRT036378 PITPNB phosphatidylinositol transfer protein beta 1 1
MIRT036379 MAD2L2 mitotic arrest deficient 2 like 2 1 1
MIRT036380 TUSC3 tumor suppressor candidate 3 1 1
MIRT036381 PRKRIP1 PRKR interacting protein 1 1 1
MIRT036382 DCAF7 DDB1 and CUL4 associated factor 7 1 1
MIRT036383 NME2 NME/NM23 nucleoside diphosphate kinase 2 1 1
MIRT036384 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 1 1
MIRT036385 SLC16A13 solute carrier family 16 member 13 1 1
MIRT036386 PRDX4 peroxiredoxin 4 1 1
MIRT036387 NXPE3 neurexophilin and PC-esterase domain family member 3 1 1
MIRT036388 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 1 1
MIRT036389 CPNE1 copine 1 1 1
MIRT036390 PSMC5 proteasome 26S subunit, ATPase 5 1 1
MIRT036391 PAK4 p21 (RAC1) activated kinase 4 1 1
MIRT059262 CELF1 CUGBP Elav-like family member 1 2 2
MIRT061283 IPO7 importin 7 2 2
MIRT080097 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT345981 BIRC5 baculoviral IAP repeat containing 5 2 8
MIRT366471 KLHL15 kelch like family member 15 2 2
MIRT379534 HNRNPK heterogeneous nuclear ribonucleoprotein K 2 2
MIRT443697 HUNK hormonally up-regulated Neu-associated kinase 2 4
MIRT472347 NETO2 neuropilin and tolloid like 2 2 2
MIRT497842 GATA6 GATA binding protein 6 2 4
MIRT510408 ZNF268 zinc finger protein 268 2 4
MIRT519621 ZNF781 zinc finger protein 781 2 2
MIRT519830 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT530712 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT530802 GPR182 G protein-coupled receptor 182 2 2
MIRT534374 SETD7 SET domain containing lysine methyltransferase 7 2 2
MIRT535541 P2RY2 purinergic receptor P2Y2 2 2
MIRT536016 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT556019 MYBL1 MYB proto-oncogene like 1 2 2
MIRT560009 ZNF525 zinc finger protein 525 2 2
MIRT560072 ZNF195 zinc finger protein 195 2 2
MIRT565948 RRAGD Ras related GTP binding D 2 2
MIRT570131 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT570887 ZNF780A zinc finger protein 780A 2 4
MIRT609775 VWC2L von Willebrand factor C domain containing protein 2 like 2 4
MIRT611445 NRIP3 nuclear receptor interacting protein 3 2 2
MIRT611975 ZNF175 zinc finger protein 175 2 2
MIRT612871 IGFBP5 insulin like growth factor binding protein 5 2 4
MIRT613012 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT617515 PTDSS1 phosphatidylserine synthase 1 2 2
MIRT636095 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT637442 ZNF324B zinc finger protein 324B 2 2
MIRT638303 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT638920 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT640590 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT646760 WDR3 WD repeat domain 3 2 2
MIRT652591 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT654866 PPL periplakin 2 2
MIRT654952 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT656021 MYO5B myosin VB 2 2
MIRT657078 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657880 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT659231 CXCR5 C-X-C motif chemokine receptor 5 2 2
MIRT662904 MED18 mediator complex subunit 18 2 2
MIRT685610 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT687424 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT692293 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT693749 ZNF383 zinc finger protein 383 2 2
MIRT695121 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695138 PRY PTPN13-like, Y-linked 2 2
MIRT709581 LETMD1 LETM1 domain containing 1 2 2
MIRT709737 TRIM27 tripartite motif containing 27 2 2
MIRT711058 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT714189 TRAF7 TNF receptor associated factor 7 2 2
MIRT715924 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT719463 SRF serum response factor 2 2
MIRT720172 PANK2 pantothenate kinase 2 2 2
MIRT720456 RAB31 RAB31, member RAS oncogene family 2 2
MIRT721642 ZNF207 zinc finger protein 207 2 2
MIRT721996 CLLU1OS chronic lymphocytic leukemia up-regulated 1 opposite strand 2 2
MIRT722187 DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 2 2
MIRT725196 PTRF caveolae associated protein 1 2 2
MIRT725518 FAM229B family with sequence similarity 229 member B 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1229 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 down-regulated
miR-1229 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-1229 Goserelin approved 47725 Microarray prostate 22674191 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1229 Fluorouracil 3385 NSC19893 approved sensitive cell line (KYSE)
hsa-miR-1229-3p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-1229-3p Doxorubicin 31703 NSC123127 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-1229-3p Fluorouracil 3385 NSC19893 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-1229-3p Vincristine 5978 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-1229-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-1229-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-1229-3p Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma cell line (Huh-7, PLC)
hsa-miR-1229-3p Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-1229-3p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-miR-1229-3p Fluorouracil 3385 NSC19893 approved resistant Low Gastric Cancer cell line (HGC-27, GFP-MKN45)
hsa-miR-1229-3p Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma cell line (Huh-7, PLC)
hsa-miR-1229-3p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-1229-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-1229-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-1229-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-1229-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1229-3p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-1229-3p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-1229-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1229-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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