miRTarBase - #MIRT036428


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pre-miRNA Information
pre-miRNA hsa-mir-1226   
Genomic Coordinates chr3: 47849555 - 47849629
Synonyms MIRN1226, hsa-mir-1226, MIR1226
Description Homo sapiens miR-1226 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1226-3p
Sequence 54| UCACCAGCCCUGUGUUCCCUAG |75
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM111744 10 COSMIC
COSM8170291 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1472927902 1 dbSNP
rs370902478 2 dbSNP
rs750372577 5 dbSNP
rs754955605 6 dbSNP
rs373981655 9 dbSNP
rs1431438028 11 dbSNP
rs747968275 12 dbSNP
rs372320878 19 dbSNP
rs141645399 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HSP90AA1   
Synonyms EL52, HEL-S-65p, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp103, Hsp89, Hsp90, LAP-2, LAP2
Description heat shock protein 90 alpha family class A member 1
Transcript NM_001017963   
Other Transcripts NM_005348   
Expression
Putative miRNA Targets on HSP90AA1
3'UTR of HSP90AA1
(miRNA target sites are highlighted)		 
>HSP90AA1|NM_001017963|3'UTR
   1 TCTCTGGCTGAGGGATGACTTACCTGTTCAGTACTCTACAATTCCTCTGATAATATATTTTCAAGGATGTTTTTCTTTAT
  81 TTTTGTTAATATTAAAAAGTCTGTATGGCATGACAACTACTTTAAGGGGAAGATAAGATTTCTGTCTACTAAGTGATGCT
 161 GTGATACCTTAGGCACTAAAGCAGAGCTAGTAATGCTTTTTGAGTTTCATGTTGGTTTATTTTCACAGATTGGGGTAACG
 241 TGCACTGTAAGACGTATGTAACATGATGTTAACTTTGTGGTCTAAAGTGTTTAGCTGTCAAGCCGGATGCCTAAGTAGAC
 321 CAAATCTTGTTATTGAAGTGTTCTGAGCTGTATCTTGATGTTTAGAAAAGTATTCGTTACATCTTGTAGGATCTACTTTT
 401 TGAACTTTTCATTCCCTGTAGTTGACAATTCTGCATGTACTAGTCCTCTAGAAATAGGTTAAACTGAAGCAACTTGATGG
 481 AAGGATCTCTCCACAGGGCTTGTTTTCCAAAGAAAAGTATTGTTTGGAGGAGCAAAGTTAAAAGCCTACCTAAGCATATC
 561 GTAAAGCTGTTCAAAAATAACTCAGACCCAGTCTTGTGGATGGAAATGTAGTGCTCGAGTCACATTCTGCTTAAAGTTGT
 641 AACAAATACAGATGAGTTAAAAGATATTGTGTGACAGTGTCTTATTTAGGGGGAAAGGGGAGTATCTGGATGACAGTTAG
 721 TGCCAAAATGTAAAACATGAGGCGCTAGCAGGAGATGGTTAAACACTAGCTGCTCCAAGGGTTGACATGGTCTTCCCAGC
 801 ATGTACTCAGCAGGTGTGGGGTGGAGCACACGTAGGCACAGAAAACAGGAATGCAGACAACATGCATCCCCTGCGTCCAT
 881 GAGTTACATGTGTTCTCTTAGTGTCCACGTTGTTTTGATGTTATTCATGGAATACCTTCTGTGTTAAATACAGTCACTTA
 961 ATTCCTTGGCCTTAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaucccuuGUGUCCCGACCAcu 5'
                  ||||||||| ||  
Target 5' gatctctcCACAGGGCTTGTtt 3'
 484 - 505 118.00 -15.70
2 
miRNA  3' gauccCUUGUGUCCCGACCACu 5'
               | || ||  || |||| 
Target 5' agcatGTACTCA--GCAGGTGt 3'
 798 - 817 117.00 -7.50
3 
miRNA  3' gaucccUUGUGUCCCGACCAcu 5'
                || :||| ||| ||  
Target 5' ggcactAAAGCAGAGCTAGTaa 3'
 172 - 193 108.00 -5.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN508680 20 COSMIC
COSN31547687 31 COSMIC
COSN30488128 47 COSMIC
COSN5746133 64 COSMIC
COSN30121940 101 COSMIC
COSN30168907 107 COSMIC
COSN23530744 132 COSMIC
COSN22901869 135 COSMIC
COSN31537635 142 COSMIC
COSN22025006 151 COSMIC
COSN28822922 178 COSMIC
COSN31586258 181 COSMIC
COSN31961039 245 COSMIC
COSN17447622 264 COSMIC
COSN20111696 275 COSMIC
COSN14451687 577 COSMIC
COSN7429126 965 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs546002924 1 dbSNP
rs780659343 2 dbSNP
rs750719586 3 dbSNP
rs532698679 4 dbSNP
rs757476486 10 dbSNP
rs972436676 11 dbSNP
rs1353423079 13 dbSNP
rs202202735 16 dbSNP
rs764120109 18 dbSNP
rs1329326877 19 dbSNP
rs1351743545 22 dbSNP
rs758432856 22 dbSNP
rs143088106 23 dbSNP
rs777775631 23 dbSNP
rs766242959 24 dbSNP
rs377540509 29 dbSNP
rs760463855 30 dbSNP
rs772944294 36 dbSNP
rs1220800393 37 dbSNP
rs767323889 38 dbSNP
rs1279269265 39 dbSNP
rs1416319789 40 dbSNP
rs112417493 41 dbSNP
rs35798224 43 dbSNP
rs748749956 44 dbSNP
rs1451713672 45 dbSNP
rs776145818 46 dbSNP
rs770491788 49 dbSNP
rs1244857785 50 dbSNP
rs1489247388 51 dbSNP
rs1194027193 56 dbSNP
rs1422668859 56 dbSNP
rs1477608573 57 dbSNP
rs776902863 57 dbSNP
rs1223006118 60 dbSNP
rs963863592 62 dbSNP
rs1019449876 63 dbSNP
rs1323001409 67 dbSNP
rs1008106440 68 dbSNP
rs373854012 72 dbSNP
rs1032129043 75 dbSNP
rs1402404388 75 dbSNP
rs979357162 78 dbSNP
rs1227880643 79 dbSNP
rs1356638592 80 dbSNP
rs966655171 83 dbSNP
rs903132894 84 dbSNP
rs1020266388 89 dbSNP
rs765372871 92 dbSNP
rs1191280796 97 dbSNP
rs1239384871 99 dbSNP
rs1473268819 99 dbSNP
rs1366707721 103 dbSNP
rs965739818 105 dbSNP
rs1019738497 111 dbSNP
rs1006970711 114 dbSNP
rs1293920868 118 dbSNP
rs554591656 119 dbSNP
rs893192002 120 dbSNP
rs116145388 122 dbSNP
rs1340631966 123 dbSNP
rs1157696958 124 dbSNP
rs1446849553 133 dbSNP
rs937454923 137 dbSNP
rs907379409 138 dbSNP
rs1281908470 139 dbSNP
rs1355308477 141 dbSNP
rs1240742947 142 dbSNP
rs555748267 146 dbSNP
rs940947200 148 dbSNP
rs908141653 149 dbSNP
rs1443161593 150 dbSNP
rs1431778524 153 dbSNP
rs1267048104 159 dbSNP
rs982454298 159 dbSNP
rs1441676435 161 dbSNP
rs538999062 163 dbSNP
rs1452266256 167 dbSNP
rs897421259 167 dbSNP
rs930984794 168 dbSNP
rs575335984 172 dbSNP
rs1174615081 173 dbSNP
rs186085934 175 dbSNP
rs919661551 182 dbSNP
rs538361947 186 dbSNP
rs1470179024 188 dbSNP
rs963812142 193 dbSNP
rs762176778 195 dbSNP
rs949105975 197 dbSNP
rs564969774 202 dbSNP
rs1307943075 206 dbSNP
rs1262692509 207 dbSNP
rs55980776 210 dbSNP
rs369711643 214 dbSNP
rs1200061307 218 dbSNP
rs1261439921 220 dbSNP
rs1199279351 228 dbSNP
rs1301633887 228 dbSNP
rs1237657508 229 dbSNP
rs1020634331 230 dbSNP
rs149051840 231 dbSNP
rs146487565 233 dbSNP
rs1174759532 236 dbSNP
rs567256737 239 dbSNP
rs1330025431 240 dbSNP
rs1465826045 240 dbSNP
rs979242729 242 dbSNP
rs375492660 243 dbSNP
rs1301947350 246 dbSNP
rs1330470783 249 dbSNP
rs1230737854 252 dbSNP
rs1435146685 253 dbSNP
rs1034401938 254 dbSNP
rs1320196687 255 dbSNP
rs1312334929 256 dbSNP
rs1219535666 260 dbSNP
rs1257495711 263 dbSNP
rs1479720757 266 dbSNP
rs1170318513 267 dbSNP
rs966922324 269 dbSNP
rs1465175695 273 dbSNP
rs200220551 275 dbSNP
rs397773688 277 dbSNP
rs1377859953 278 dbSNP
rs72520876 279 dbSNP
rs1169603641 280 dbSNP
rs1491132162 280 dbSNP
rs3831488 280 dbSNP
rs397717863 280 dbSNP
rs767388978 280 dbSNP
rs913843293 284 dbSNP
rs976391279 287 dbSNP
rs1293637739 290 dbSNP
rs1001614054 292 dbSNP
rs11547511 294 dbSNP
rs907328376 297 dbSNP
rs1045911909 299 dbSNP
rs2298878 304 dbSNP
rs531569646 305 dbSNP
rs569173401 307 dbSNP
rs1306003236 309 dbSNP
rs954116788 311 dbSNP
rs1465763962 312 dbSNP
rs1266116967 313 dbSNP
rs775842618 315 dbSNP
rs1049795723 316 dbSNP
rs1220981865 316 dbSNP
rs1265790545 323 dbSNP
rs1488846223 326 dbSNP
rs1192454265 331 dbSNP
rs1259179287 332 dbSNP
rs930954268 332 dbSNP
rs1164797766 335 dbSNP
rs1367442420 336 dbSNP
rs1422660414 336 dbSNP
rs115690563 337 dbSNP
rs1483014788 343 dbSNP
rs1256870615 348 dbSNP
rs761876180 352 dbSNP
rs1360053308 354 dbSNP
rs897299238 355 dbSNP
rs1339846410 362 dbSNP
rs1296748815 363 dbSNP
rs1039378197 375 dbSNP
rs942451252 376 dbSNP
rs182139510 378 dbSNP
rs1331563005 380 dbSNP
rs144076402 383 dbSNP
rs1402470925 385 dbSNP
rs540861447 388 dbSNP
rs1054722296 389 dbSNP
rs937644602 390 dbSNP
rs1436946262 393 dbSNP
rs776894543 395 dbSNP
rs1156601083 396 dbSNP
rs1058078 401 dbSNP
rs945257076 405 dbSNP
rs879155627 408 dbSNP
rs1450568020 410 dbSNP
rs1405413219 411 dbSNP
rs1450478753 415 dbSNP
rs1375297812 416 dbSNP
rs1311560692 417 dbSNP
rs1378223517 418 dbSNP
rs913716905 422 dbSNP
rs976063707 424 dbSNP
rs957342013 426 dbSNP
rs1262067450 427 dbSNP
rs1459724917 431 dbSNP
rs1423386202 436 dbSNP
rs1257081139 439 dbSNP
rs1034346315 440 dbSNP
rs1175483573 442 dbSNP
rs1426971092 443 dbSNP
rs1001561838 445 dbSNP
rs1273600149 446 dbSNP
rs11547531 447 dbSNP
rs544933619 448 dbSNP
rs1005030045 449 dbSNP
rs1468441475 451 dbSNP
rs886610297 454 dbSNP
rs879027014 458 dbSNP
rs568538336 472 dbSNP
rs548709077 476 dbSNP
rs1401207536 477 dbSNP
rs995489817 478 dbSNP
rs900803204 480 dbSNP
rs1039331239 485 dbSNP
rs1297006094 486 dbSNP
rs1027097628 487 dbSNP
rs1370386298 487 dbSNP
rs1340608264 491 dbSNP
rs1294624119 492 dbSNP
rs942382721 492 dbSNP
rs912289152 495 dbSNP
rs974551065 496 dbSNP
rs1051288917 499 dbSNP
rs1202329277 508 dbSNP
rs945865634 512 dbSNP
rs1488785290 515 dbSNP
rs913046868 520 dbSNP
rs1410934768 521 dbSNP
rs1399250865 530 dbSNP
rs1162015542 531 dbSNP
rs1479576222 532 dbSNP
rs1173144665 537 dbSNP
rs575140426 541 dbSNP
rs1369081693 544 dbSNP
rs957253629 545 dbSNP
rs927225724 550 dbSNP
rs773910133 554 dbSNP
rs1302913721 557 dbSNP
rs191117771 558 dbSNP
rs186290063 559 dbSNP
rs1024355329 560 dbSNP
rs1212258045 561 dbSNP
rs35754658 561 dbSNP
rs1291412008 567 dbSNP
rs190137720 569 dbSNP
rs1266467374 584 dbSNP
rs1489176904 587 dbSNP
rs11547545 588 dbSNP
rs1242872836 592 dbSNP
rs1475209490 593 dbSNP
rs1166171432 595 dbSNP
rs1287615290 604 dbSNP
rs536071141 606 dbSNP
rs546245419 607 dbSNP
rs1364084023 609 dbSNP
rs1421854434 610 dbSNP
rs900734541 611 dbSNP
rs549111987 614 dbSNP
rs1017830031 616 dbSNP
rs1006472514 617 dbSNP
rs944491130 622 dbSNP
rs890799015 624 dbSNP
rs1355801856 627 dbSNP
rs1216982125 631 dbSNP
rs986030355 633 dbSNP
rs749124836 634 dbSNP
rs945781979 638 dbSNP
rs777749650 640 dbSNP
rs1054680467 641 dbSNP
rs1383887422 645 dbSNP
rs1288661133 649 dbSNP
rs149779281 651 dbSNP
rs935835621 653 dbSNP
rs1384779216 656 dbSNP
rs1398560878 662 dbSNP
rs1335834188 663 dbSNP
rs556803066 666 dbSNP
rs769688719 667 dbSNP
rs1183755168 668 dbSNP
rs1260637479 669 dbSNP
rs1378942161 670 dbSNP
rs1240856653 671 dbSNP
rs1278737743 675 dbSNP
rs34287031 676 dbSNP
rs1386664750 678 dbSNP
rs1002401794 679 dbSNP
rs1203044984 681 dbSNP
rs903568400 686 dbSNP
rs1395860299 687 dbSNP
rs1022379107 688 dbSNP
rs1183212938 697 dbSNP
rs1363559122 704 dbSNP
rs569231446 705 dbSNP
rs1468875883 706 dbSNP
rs983512336 709 dbSNP
rs1429470820 710 dbSNP
rs1468979357 716 dbSNP
rs1334102642 720 dbSNP
rs34767631 722 dbSNP
rs368736722 722 dbSNP
rs1328158532 723 dbSNP
rs552328672 729 dbSNP
rs1235098050 733 dbSNP
rs1275228329 735 dbSNP
rs780982911 743 dbSNP
rs115514898 744 dbSNP
rs1261300689 746 dbSNP
rs1232153544 754 dbSNP
rs566878846 755 dbSNP
rs1459180578 757 dbSNP
rs1244729499 764 dbSNP
rs1196474596 767 dbSNP
rs1250378727 770 dbSNP
rs888941210 773 dbSNP
rs930546203 778 dbSNP
rs973518262 781 dbSNP
rs1197916169 785 dbSNP
rs1452055796 786 dbSNP
rs964850714 787 dbSNP
rs1017777546 790 dbSNP
rs1462008221 791 dbSNP
rs1166842352 795 dbSNP
rs1206274819 795 dbSNP
rs1009094575 798 dbSNP
rs1327906907 799 dbSNP
rs547136209 801 dbSNP
rs974489235 803 dbSNP
rs1404541790 804 dbSNP
rs1281556881 806 dbSNP
rs1228160069 813 dbSNP
rs186947478 813 dbSNP
rs1029722383 814 dbSNP
rs1009931307 818 dbSNP
rs891513223 820 dbSNP
rs1212219445 821 dbSNP
rs1054231685 824 dbSNP
rs181396530 827 dbSNP
rs940009092 828 dbSNP
rs1197744022 829 dbSNP
rs1059623 831 dbSNP
rs992190538 832 dbSNP
rs905704357 833 dbSNP
rs1289448295 836 dbSNP
rs1191778444 839 dbSNP
rs1370902525 843 dbSNP
rs189791627 846 dbSNP
rs1436221466 853 dbSNP
rs1372359989 859 dbSNP
rs1364905750 860 dbSNP
rs926789577 861 dbSNP
rs150605311 865 dbSNP
rs917198702 869 dbSNP
rs1432964490 870 dbSNP
rs1387937390 872 dbSNP
rs544715118 874 dbSNP
rs372342215 875 dbSNP
rs1324800159 879 dbSNP
rs780168650 879 dbSNP
rs1423344436 883 dbSNP
rs1293077935 887 dbSNP
rs572874004 888 dbSNP
rs1177181687 891 dbSNP
rs558996333 896 dbSNP
rs1288624852 902 dbSNP
rs956379016 906 dbSNP
rs542330350 908 dbSNP
rs1008645480 909 dbSNP
rs1183698911 915 dbSNP
rs1396774555 915 dbSNP
rs888993336 916 dbSNP
rs1442717782 923 dbSNP
rs973465918 923 dbSNP
rs964798636 924 dbSNP
rs1454472143 926 dbSNP
rs1050255038 927 dbSNP
rs1383105807 934 dbSNP
rs754032436 935 dbSNP
rs1315826081 936 dbSNP
rs994639505 942 dbSNP
rs1059629 944 dbSNP
rs987621599 950 dbSNP
rs1238804112 951 dbSNP
rs1258536401 953 dbSNP
rs184420805 957 dbSNP
rs745651687 957 dbSNP
rs1459921956 961 dbSNP
rs139925232 964 dbSNP
rs1010296681 965 dbSNP
rs376414746 969 dbSNP
rs1156708658 970 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site CDS
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaucccuuGUGUCCCGACCACu 5'
                  ::|| |||||||| 
Target 5' --aagcttTGCA-GGCTGGTGc 3'
 		1 - 19
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells -0.549 3.3e-3 -0.619 8.2e-4 23 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.47 8.9e-3 0.469 9.0e-3 25 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.296 1.0e-1 0.388 4.5e-2 20 Click to see details
GSE38226 Liver fibrosis -0.265 1.2e-1 -0.300 9.3e-2 21 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.485 1.6e-1 0.657 7.8e-2 6 Click to see details
GSE17498 Multiple myeloma -0.134 2.0e-1 -0.074 3.2e-1 40 Click to see details
GSE21687 Ependynoma primary tumors 0.087 2.5e-1 0.132 1.5e-1 64 Click to see details
GSE28544 Breast cancer 0.136 2.6e-1 0.181 2.0e-1 24 Click to see details
GSE26953 Aortic valvular endothelial cells -0.066 3.8e-1 -0.162 2.2e-1 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.051 4.0e-1 0.065 3.8e-1 25 Click to see details
GSE32688 Pancreatic cancer -0.015 4.7e-1 -0.080 3.3e-1 32 Click to see details
GSE28260 Renal cortex and medulla 0.016 4.8e-1 -0.010 4.9e-1 13 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BLCA -0.626 0.01 -0.503 0.03 14 Click to see details
CHOL 0.795 0.03 0.600 0.1 6 Click to see details
KICH -0.433 0.03 -0.244 0.16 19 Click to see details
STAD 0.345 0.04 0.363 0.03 27 Click to see details
PAAD -0.908 0.05 -0.800 0.1 4 Click to see details
THCA -0.185 0.09 -0.274 0.02 54 Click to see details
LUAD 0.571 0.12 0.600 0.1 6 Click to see details
KIRP 0.211 0.12 0.304 0.05 32 Click to see details
PCPG 0.894 0.15 1.000 0.5 3 Click to see details
LIHC 0.165 0.15 0.140 0.19 41 Click to see details
ESCA 0.348 0.2 0.286 0.25 8 Click to see details
HNSC 0.139 0.23 0.027 0.44 30 Click to see details
COAD 0.25 0.29 0.393 0.19 7 Click to see details
KIRC -0.054 0.35 -0.163 0.12 56 Click to see details
BRCA 0.046 0.36 0.033 0.4 66 Click to see details
PRAD 0.072 0.37 0.083 0.35 25 Click to see details
UCEC 0.081 0.37 0.181 0.23 19 Click to see details
LUSC 0.027 0.44 0.093 0.29 36 Click to see details
LUSC 0.027 0.44 0.093 0.29 36 Click to see details
LUSC 0.027 0.44 0.093 0.29 36 Click to see details
LUSC 0.027 0.44 0.093 0.29 36 Click to see details
210 hsa-miR-1226-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005492 MUC1 mucin 1, cell surface associated 3 1
MIRT036409 IGF1R insulin like growth factor 1 receptor 1 1
MIRT036410 UBE2A ubiquitin conjugating enzyme E2 A 1 1
MIRT036411 WDR1 WD repeat domain 1 1 1
MIRT036412 HIST1H4B histone cluster 1 H4 family member b 1 1
MIRT036413 BLMH bleomycin hydrolase 1 1
MIRT036414 HSPA1B heat shock protein family A (Hsp70) member 1B 1 1
MIRT036415 KDM2A lysine demethylase 2A 1 1
MIRT036416 RPL35 ribosomal protein L35 1 1
MIRT036417 KARS lysyl-tRNA synthetase 1 1
MIRT036418 AVL9 AVL9 cell migration associated 1 1
MIRT036419 GLUD2 glutamate dehydrogenase 2 1 1
MIRT036420 GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 1 1
MIRT036421 CABIN1 calcineurin binding protein 1 1 1
MIRT036422 LEPREL4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 1 1
MIRT036423 CSDE1 cold shock domain containing E1 1 1
MIRT036424 UBE2G1 ubiquitin conjugating enzyme E2 G1 1 1
MIRT036425 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 1 1
MIRT036426 CCDC47 coiled-coil domain containing 47 1 1
MIRT036427 SCAMP1 secretory carrier membrane protein 1 1 1
MIRT036428 HSP90AA1 heat shock protein 90 alpha family class A member 1 1 1
MIRT036429 GIMAP8 GTPase, IMAP family member 8 1 1
MIRT036430 MBTPS2 membrane bound transcription factor peptidase, site 2 1 1
MIRT036431 RCC2 regulator of chromosome condensation 2 1 1
MIRT036432 DUT deoxyuridine triphosphatase 1 1
MIRT036433 XYLT2 xylosyltransferase 2 1 1
MIRT036434 SUN2 Sad1 and UNC84 domain containing 2 1 1
MIRT036435 SACS sacsin molecular chaperone 1 1
MIRT036436 C12orf29 chromosome 12 open reading frame 29 1 1
MIRT036437 PSMB2 proteasome subunit beta 2 1 1
MIRT036438 PAF1 PAF1 homolog, Paf1/RNA polymerase II complex component 1 1
MIRT036439 SCAMP4 secretory carrier membrane protein 4 1 1
MIRT036440 PIM2 Pim-2 proto-oncogene, serine/threonine kinase 1 1
MIRT036441 JUNB JunB proto-oncogene, AP-1 transcription factor subunit 1 1
MIRT036442 TBX18 T-box 18 1 1
MIRT036443 ACIN1 apoptotic chromatin condensation inducer 1 1 1
MIRT036444 CYB5B cytochrome b5 type B 1 1
MIRT036445 ATXN2 ataxin 2 1 1
MIRT036446 TBX3 T-box 3 1 1
MIRT036447 EPB41L1 erythrocyte membrane protein band 4.1 like 1 1 1
MIRT036448 TMEM25 transmembrane protein 25 1 1
MIRT036449 ZBTB4 zinc finger and BTB domain containing 4 1 1
MIRT036450 NDRG3 NDRG family member 3 1 1
MIRT036451 CPSF3L integrator complex subunit 11 1 1
MIRT036452 SORBS2 sorbin and SH3 domain containing 2 1 1
MIRT036453 RPA2 replication protein A2 1 1
MIRT036454 LONRF1 LON peptidase N-terminal domain and ring finger 1 1 1
MIRT036455 ZNF629 zinc finger protein 629 1 1
MIRT036456 NOP2 NOP2 nucleolar protein 1 1
MIRT036457 KIAA1644 KIAA1644 1 1
MIRT036458 HSPA9 heat shock protein family A (Hsp70) member 9 1 1
MIRT036459 ITPR3 inositol 1,4,5-trisphosphate receptor type 3 1 1
MIRT036460 TM9SF4 transmembrane 9 superfamily member 4 1 1
MIRT036461 SLC1A5 solute carrier family 1 member 5 1 1
MIRT036462 EXOC8 exocyst complex component 8 1 1
MIRT036463 ATP6AP2 ATPase H+ transporting accessory protein 2 1 1
MIRT036464 HIST1H4C histone cluster 1 H4 family member c 1 1
MIRT036465 ZDHHC4 zinc finger DHHC-type containing 4 1 1
MIRT036466 ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit 1 1
MIRT036467 LIMS1 LIM zinc finger domain containing 1 1 1
MIRT036468 RBM27 RNA binding motif protein 27 1 1
MIRT036469 EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase 1 1
MIRT036470 RABL6 RAB, member RAS oncogene family like 6 1 1
MIRT036471 RBM10 RNA binding motif protein 10 1 1
MIRT036472 RABGGTB Rab geranylgeranyltransferase beta subunit 1 1
MIRT036473 PFKL phosphofructokinase, liver type 1 1
MIRT036474 TOP2A DNA topoisomerase II alpha 1 1
MIRT036475 KIAA1671 KIAA1671 1 1
MIRT036476 EIF3C eukaryotic translation initiation factor 3 subunit C 1 1
MIRT036477 IPO7 importin 7 1 1
MIRT036478 CTDNEP1 CTD nuclear envelope phosphatase 1 1 1
MIRT036479 ZBTB7B zinc finger and BTB domain containing 7B 1 1
MIRT036480 GPBP1L1 GC-rich promoter binding protein 1 like 1 1 1
MIRT036481 PANK3 pantothenate kinase 3 1 1
MIRT036482 SLC35F6 solute carrier family 35 member F6 1 1
MIRT036483 RPL36A ribosomal protein L36a 1 1
MIRT036484 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1 1
MIRT036485 AKIP1 A-kinase interacting protein 1 1 1
MIRT036486 C1orf43 chromosome 1 open reading frame 43 1 1
MIRT036487 ACTG1 actin gamma 1 1 1
MIRT036488 EDC4 enhancer of mRNA decapping 4 1 1
MIRT036489 FTSJD2 cap methyltransferase 1 1 1
MIRT036490 GNB2L1 receptor for activated C kinase 1 1 1
MIRT036491 AP2M1 adaptor related protein complex 2 mu 1 subunit 1 1
MIRT036492 ASCC3 activating signal cointegrator 1 complex subunit 3 1 1
MIRT036493 PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha 1 1
MIRT036494 ZBTB40 zinc finger and BTB domain containing 40 1 1
MIRT036495 PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 1 1
MIRT036496 CTNNB1 catenin beta 1 1 1
MIRT036497 CEBPA CCAAT/enhancer binding protein alpha 1 1
MIRT036498 PKN3 protein kinase N3 1 1
MIRT036499 FAM3C family with sequence similarity 3 member C 1 1
MIRT036500 IDH1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic 1 1
MIRT036501 CKAP4 cytoskeleton associated protein 4 1 1
MIRT036502 GCN1L1 GCN1, eIF2 alpha kinase activator homolog 1 1
MIRT036503 ASTL astacin like metalloendopeptidase 1 1
MIRT036504 ADAR adenosine deaminase, RNA specific 1 1
MIRT036505 IRAK1 interleukin 1 receptor associated kinase 1 1 1
MIRT036506 ALDH1B1 aldehyde dehydrogenase 1 family member B1 1 1
MIRT036507 HSPB8 heat shock protein family B (small) member 8 1 1
MIRT036508 MCM2 minichromosome maintenance complex component 2 1 1
MIRT036509 SGPL1 sphingosine-1-phosphate lyase 1 1 1
MIRT036510 SIMC1 SUMO interacting motifs containing 1 1 1
MIRT036511 PPIA peptidylprolyl isomerase A 1 1
MIRT036512 CENPF centromere protein F 1 1
MIRT036513 PRPF6 pre-mRNA processing factor 6 1 1
MIRT036514 CHD3 chromodomain helicase DNA binding protein 3 1 1
MIRT036515 PBRM1 polybromo 1 1 1
MIRT036516 USP24 ubiquitin specific peptidase 24 1 1
MIRT036517 UQCC ubiquinol-cytochrome c reductase complex assembly factor 1 1 1
MIRT036518 ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 2 3
MIRT036519 CNTNAP3 contactin associated protein like 3 1 1
MIRT036520 DDT D-dopachrome tautomerase 1 1
MIRT036521 ZNF395 zinc finger protein 395 1 1
MIRT036522 NDUFA5 NADH:ubiquinone oxidoreductase subunit A5 1 1
MIRT036523 SLC25A39 solute carrier family 25 member 39 1 1
MIRT036524 NCKIPSD NCK interacting protein with SH3 domain 1 1
MIRT036525 AAMP angio associated migratory cell protein 1 1
MIRT036526 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 1 1
MIRT036527 AGPAT6 glycerol-3-phosphate acyltransferase 4 1 1
MIRT036528 QPRT quinolinate phosphoribosyltransferase 1 1
MIRT036529 ABHD14B abhydrolase domain containing 14B 1 1
MIRT036530 BIRC5 baculoviral IAP repeat containing 5 1 1
MIRT036531 BAG6 BCL2 associated athanogene 6 1 1
MIRT036532 MRPS26 mitochondrial ribosomal protein S26 1 1
MIRT036533 KIF4B kinesin family member 4B 1 1
MIRT036534 TUBB4B tubulin beta 4B class IVb 1 1
MIRT036535 FAM168B family with sequence similarity 168 member B 1 1
MIRT036536 TUBB4A tubulin beta 4A class IVa 1 1
MIRT036537 AKR1B1 aldo-keto reductase family 1 member B 1 1
MIRT248779 ATXN7L3B ataxin 7 like 3B 2 2
MIRT279943 SLC39A9 solute carrier family 39 member 9 2 4
MIRT337171 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 4
MIRT443071 ABLIM1 actin binding LIM protein 1 2 2
MIRT451814 CDCA3 cell division cycle associated 3 2 2
MIRT467748 SLC36A1 solute carrier family 36 member 1 2 2
MIRT473511 MAZ MYC associated zinc finger protein 2 2
MIRT476233 GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2 2
MIRT486918 GPX1 glutathione peroxidase 1 2 2
MIRT489205 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT495363 AATF apoptosis antagonizing transcription factor 2 2
MIRT495390 VPS51 VPS51, GARP complex subunit 2 2
MIRT495594 ARHGEF28 Rho guanine nucleotide exchange factor 28 2 2
MIRT495692 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT495833 EHD1 EH domain containing 1 2 2
MIRT499765 CIRH1A UTP4, small subunit processome component 2 10
MIRT504903 CCDC86 coiled-coil domain containing 86 2 2
MIRT513211 RFT1 RFT1 homolog 2 2
MIRT519628 ZNF781 zinc finger protein 781 2 2
MIRT519843 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT530064 PLXNA4 plexin A4 2 2
MIRT531308 GPR26 G protein-coupled receptor 26 2 2
MIRT533268 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT534128 SNX13 sorting nexin 13 2 2
MIRT534291 SLAIN2 SLAIN motif family member 2 2 2
MIRT535866 MORF4L1 mortality factor 4 like 1 2 2
MIRT536022 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT539500 ACTN4 actinin alpha 4 2 2
MIRT547451 MBD4 methyl-CpG binding domain 4, DNA glycosylase 2 2
MIRT560019 ZNF525 zinc finger protein 525 2 2
MIRT560084 ZNF195 zinc finger protein 195 2 2
MIRT568722 GRASP general receptor for phosphoinositides 1 associated scaffold protein 2 2
MIRT570893 ZNF780A zinc finger protein 780A 2 2
MIRT571250 FADS6 fatty acid desaturase 6 2 2
MIRT573401 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT576568 Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 2 2
MIRT612131 NDUFA10 NADH:ubiquinone oxidoreductase subunit A10 2 2
MIRT613022 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT613861 TNFRSF9 TNF receptor superfamily member 9 2 4
MIRT614966 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT616581 FAM107A family with sequence similarity 107 member A 2 2
MIRT626205 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT640512 ANTXR1 anthrax toxin receptor 1 2 2
MIRT640536 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT641548 MOCOS molybdenum cofactor sulfurase 2 2
MIRT641683 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT642859 RNF135 ring finger protein 135 2 2
MIRT649106 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT651844 USP1 ubiquitin specific peptidase 1 2 2
MIRT659044 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659663 CDC73 cell division cycle 73 2 2
MIRT659959 CXCL10 C-X-C motif chemokine ligand 10 2 2
MIRT672556 BRMS1L breast cancer metastasis-suppressor 1 like 2 2
MIRT675601 ZNF106 zinc finger protein 106 2 2
MIRT676034 C9orf69 transmembrane protein 250 2 2
MIRT678691 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT682730 MSANTD1 Myb/SANT DNA binding domain containing 1 2 2
MIRT682993 RNF40 ring finger protein 40 2 2
MIRT687354 NUP98 nucleoporin 98 2 2
MIRT697178 INMT indolethylamine N-methyltransferase 2 2
MIRT698735 STX12 syntaxin 12 2 2
MIRT699632 SH3BP5 SH3 domain binding protein 5 2 2
MIRT704560 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT704708 CHEK1 checkpoint kinase 1 2 2
MIRT709863 PDIK1L PDLIM1 interacting kinase 1 like 2 2
MIRT712792 ZNF154 zinc finger protein 154 2 2
MIRT712918 MRGPRF MAS related GPR family member F 2 2
MIRT714040 ELMO1 engulfment and cell motility 1 2 2
MIRT714417 TBC1D16 TBC1 domain family member 16 2 2
MIRT714539 ZBTB39 zinc finger and BTB domain containing 39 2 2
MIRT715975 FADS3 fatty acid desaturase 3 2 2
MIRT716452 TMPRSS11BNL TMPRSS11B N-terminal like, pseudogene 2 2
MIRT716996 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT718745 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT719103 PCYT1A phosphate cytidylyltransferase 1, choline, alpha 2 2
MIRT721047 TRIM67 tripartite motif containing 67 2 2
MIRT721082 FTSJ2 mitochondrial rRNA methyltransferase 2 2 2
MIRT722291 PMPCA peptidase, mitochondrial processing alpha subunit 2 2
MIRT722940 NHP2L1 small nuclear ribonucleoprotein 13 2 2
MIRT725148 SLC43A1 solute carrier family 43 member 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1226 Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma tissue
hsa-mir-1226 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-1226 Androstenedione 6128 NSC9563 resistant cell line (MCF-7)
hsa-mir-1226 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-mir-1226 Cisplatin 5460033 NSC119875 approved sensitive cell line (KYSE)
hsa-mir-1226 Fluorouracil 3385 NSC19893 approved sensitive cell line (KYSE)
hsa-mir-1226 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-1226-3p Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-1226-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-1226-3p Fluorouracil 3385 NSC19893 approved sensitive High Esophageal Squamous Cell Carcinoma cell line (KYSE410)
hsa-miR-1226-3p Doxorubicin 31703 NSC123127 approved sensitive High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-1226-3p Aromatase Inhibitor resistant Low Breast Cancer cell line (MCF-7)
hsa-miR-1226-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-1226-3p Cisplatin 5460033 NSC119875 approved sensitive Low Esophageal Squamous Cell Carcinoma cell line (KYSE-70, KYSE-140, KYSE-180, KYSE-270, KYSE-410, KYSE-520)
hsa-miR-1226-3p Fluorouracil 3385 NSC19893 approved sensitive Low Esophageal Squamous Cell Carcinoma cell line (KYSE-70, KYSE-140, KYSE-180, KYSE-270, KYSE-410, KYSE-520)
hsa-miR-1226-3p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-1226-3p Sorafenib 216239 NSC747971 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2, SK-HEP-1)
hsa-miR-1226-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-1226-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1226-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-1226-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1226-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-miR-1226-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-1226-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM43)
hsa-miR-1226-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-1226-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-1226-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-1226-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (HS578T)
hsa-miR-1226-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-1226-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-1226-3p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-1226-3p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-1226-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-1226-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1226-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-1226-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (OVCAR3)
hsa-miR-1226-3p Cisplatin 5460033 NSC119875 approved resistant cell line (H460)

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