miRTarBase - #MIRT036434


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pre-miRNA Information
pre-miRNA hsa-mir-1226   
Genomic Coordinates chr3: 47849555 - 47849629
Synonyms MIRN1226, hsa-mir-1226, MIR1226
Description Homo sapiens miR-1226 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1226-3p
Sequence 54| UCACCAGCCCUGUGUUCCCUAG |75
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM111744 10 COSMIC
COSM8170291 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1472927902 1 dbSNP
rs370902478 2 dbSNP
rs750372577 5 dbSNP
rs754955605 6 dbSNP
rs373981655 9 dbSNP
rs1431438028 11 dbSNP
rs747968275 12 dbSNP
rs372320878 19 dbSNP
rs141645399 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SUN2   
Synonyms UNC84B
Description Sad1 and UNC84 domain containing 2
Transcript NM_015374   
Expression
Putative miRNA Targets on SUN2
3'UTR of SUN2
(miRNA target sites are highlighted)		 
>SUN2|NM_015374|3'UTR
   1 CCCTGCTTACTGGTGCCTGCTGCCAGCCATCTGGGAGTGGGTGAACAGCACCCCGCCGCTTCCCCCACACGCTTGCTCGG
  81 CGCTCTGACTTCTAGGAGCACAAGAGAGGAGCCTGTGGCCCCATGCAGATGAAAAGGACGGGCAGGGTCTCCTGAGCAGC
 161 AGGTGGCTCGAGGCGGTTAGCAGGCTCCAGCAGCTCCCTTCTTCCTTCCCTCTGTGCCCGTGGCGTCTGCTTCCCATCCT
 241 GGGAGTGTGTATATATGTAGCATATCATGGGGGACTGGGAAGTTGGGAGAGGTAGGACCTGACTGGTCTTGGCTGGGGTC
 321 AGGGGCTGGTGCCTGGGAGCTGATGAAGCAGGTGCCAGGGCTGTGGGAGGGGCAAGCTACGGCCTGGGCTAGGTGAGCTG
 401 CCTCTGCCCCTGGGCAAGGAAGCGAGGCCCTCTGGGAGGAGGGTGCTTAGCTCCAGAGCAGGATGGGACTTCCCCAGGCA
 481 GGAAGCACTTGATGGAGAGCTGCCCAGCTCTCCTACAAGGTTAGTGCCCTCCACCTAGGGAAGCATGAACCACAGGGTCC
 561 CTGAGGGCCTTCGACAAAAGTGTGTATTTGTCCCGGGGAGGGTAGCAGTGGGCCATGGGGCTTCTTGTGCCCTAAAGGGG
 641 ACTGGCTGCTGTGATCTTCTAAGGGGCCCAGGGCCAACCCTGTAGGCTTCCCCTCTGCTGGGGACGGTAGTTGCTTTTCT
 721 CTCTCCTGATGCTAGGTTGGGGCCCACCCTGCTCCCTGTTCCTGCTAGGGCCTGCCAGTGCCCCTGAGCTTGCTTTCCAC
 801 ATTCTCCCAGGGTATGGAGACCTAGACCTGTCTTTGGGGCCATTAGCATCTGGGGTTATAGCAAGAAGAGTGGGGAGCAT
 881 GGAACTCCTGGGCTCTTGTGGGGACGTTCAGGGTATCGGGGTGCGAGGTCTGTCTGCACCGGCCCCCACATCTAACCAGG
 961 CCCTGATGTAGGGGTCGTCCGCTCAGGCTGCCCCCTTGGGCTCTTGCAGCTCTTGTTCAGGTAGTCGCCCTTCTGGTTTG
1041 TTCTCTGTGGGGCAGTTGGTGGGGGCTGGGGGAAGAGGCTGGCAGAAGTTACCCTGGATAGGGAAGGGGGAGGAGGGGAC
1121 TTTTAGAGCCAGCAGGCCCCACTGTATTATGTATATATTTTTCAAGGTCTGTTTTTCTAACTGAAAAGCTAAGGGCTTGA
1201 TTCCTAGCCCCGTTCTGTGGGGCACTGGGTGATACTCAGTTTCTTGTTCCTGGCCGTGGAGAGGGGCCTGGGGCACTGGT
1281 TCCGGCTGTGTCTGGTGGTCTGGCTGCGGGGAAGGGGCAAGAAGGCGGGCAGGCCTTCACTGCAGCACTGAGCCTCAAAT
1361 CCGCTCTGGAGCATGAGGCTGGATGCAGTGGTGGTGAGGCCGCCCCGCTCCATCCCGAGGCAGCCAGGGTTTGTTTTGCG
1441 CTCTCCTGTCACAAATGCTGCACTATTGGTTCTTAAGTTTTTTATCTCCAGATCCTAATTTATGCCTATGCAAAAAATAA
1521 ATGACGCCCAAGAGCTGTGGGATGTGGCTTTCAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauCCCUUGUGUCCCGACCACu 5'
             |||: || :||||||||| 
Target 5' gctGGGGTCA-GGGGCTGGTGc 3'
 312 - 332 166.00 -29.80
2 
miRNA  3' gaucCCUUGUGUCCCGACC-ACu 5'
              |||:||:: |||||| || 
Target 5' ctctGGAGCATGAGGCTGGATGc 3'
 1364 - 1386 138.00 -22.80
3 
miRNA  3' gaucCCUUGUGUCCCGACCACu 5'
              ||::||    |:||||| 
Target 5' ctgtGGGGCA----GTTGGTGg 3'
 1045 - 1062 132.00 -17.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM7274828 54 COSMIC
COSM6858196 56 COSMIC
COSM5513714 58 COSMIC
COSM4970226 61 COSMIC
COSM5788753 68 COSMIC
COSM3740425 80 COSMIC
COSM7234064 81 COSMIC
COSM7690751 92 COSMIC
COSM7313166 103 COSMIC
COSM8924150 139 COSMIC
COSM5513713 142 COSMIC
COSM1632595 155 COSMIC
COSM9639833 183 COSMIC
COSM6035942 224 COSMIC
COSN30526812 333 COSMIC
COSN30531576 362 COSMIC
COSN29985369 452 COSMIC
COSN8018635 679 COSMIC
COSN31782863 1112 COSMIC
COSN30748069 1133 COSMIC
COSN31579402 1142 COSMIC
COSN31780678 1162 COSMIC
COSN1261922 1207 COSMIC
COSN20094002 1228 COSMIC
COSN28750653 1301 COSMIC
COSN28662101 1308 COSMIC
COSN26718195 1317 COSMIC
COSN28752038 1429 COSMIC
COSN31545823 1477 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1052817307 1 dbSNP
rs369326957 6 dbSNP
rs1255819599 8 dbSNP
rs1180449203 15 dbSNP
rs1319946857 16 dbSNP
rs1484473658 17 dbSNP
rs1258775664 19 dbSNP
rs935167279 22 dbSNP
rs753127205 24 dbSNP
rs767974215 27 dbSNP
rs748307914 29 dbSNP
rs867376059 33 dbSNP
rs1310196621 38 dbSNP
rs1488181918 39 dbSNP
rs759788009 40 dbSNP
rs374929327 41 dbSNP
rs979124845 43 dbSNP
rs1297431314 44 dbSNP
rs771079463 46 dbSNP
rs763096775 47 dbSNP
rs773348534 50 dbSNP
rs1445878573 51 dbSNP
rs1164153486 52 dbSNP
rs769852557 54 dbSNP
rs748133609 55 dbSNP
rs1033817079 57 dbSNP
rs538539297 58 dbSNP
rs571499480 61 dbSNP
rs1193507114 63 dbSNP
rs146692436 66 dbSNP
rs779141062 67 dbSNP
rs758126218 68 dbSNP
rs750092949 69 dbSNP
rs756800474 70 dbSNP
rs753287130 71 dbSNP
rs528230600 72 dbSNP
rs760038731 78 dbSNP
rs567466607 79 dbSNP
rs377680508 81 dbSNP
rs763220478 82 dbSNP
rs773401691 85 dbSNP
rs755161148 86 dbSNP
rs1462358750 87 dbSNP
rs1382803304 91 dbSNP
rs769901902 93 dbSNP
rs761834197 94 dbSNP
rs1308817134 96 dbSNP
rs1459656389 100 dbSNP
rs776727703 102 dbSNP
rs530243555 103 dbSNP
rs1464432500 104 dbSNP
rs372361156 108 dbSNP
rs1160171425 109 dbSNP
rs544657139 112 dbSNP
rs745562110 124 dbSNP
rs1175657317 125 dbSNP
rs955253521 127 dbSNP
rs778676789 131 dbSNP
rs1468639101 134 dbSNP
rs191692906 139 dbSNP
rs1376237446 140 dbSNP
rs41280839 141 dbSNP
rs1008995657 146 dbSNP
rs755504957 147 dbSNP
rs962887548 151 dbSNP
rs1251780927 154 dbSNP
rs540939208 155 dbSNP
rs766779250 157 dbSNP
rs758732189 159 dbSNP
rs750749733 160 dbSNP
rs1017533492 168 dbSNP
rs754192471 168 dbSNP
rs765469369 169 dbSNP
rs573329414 170 dbSNP
rs1402913631 174 dbSNP
rs140105822 175 dbSNP
rs1465967217 178 dbSNP
rs1256888959 181 dbSNP
rs1376503096 184 dbSNP
rs1014257610 185 dbSNP
rs1038031322 186 dbSNP
rs1454373114 190 dbSNP
rs1237138368 191 dbSNP
rs1176432353 193 dbSNP
rs542299684 196 dbSNP
rs1052346050 197 dbSNP
rs369532619 198 dbSNP
rs1189291881 205 dbSNP
rs1431153653 212 dbSNP
rs185691254 219 dbSNP
rs775542638 220 dbSNP
rs1342742967 224 dbSNP
rs772028961 225 dbSNP
rs1236519034 239 dbSNP
rs1348722644 244 dbSNP
rs1308714376 245 dbSNP
rs745689048 249 dbSNP
rs942412220 252 dbSNP
rs1281836699 253 dbSNP
rs939117599 261 dbSNP
rs879025503 262 dbSNP
rs1223757204 264 dbSNP
rs556538305 265 dbSNP
rs980928456 267 dbSNP
rs1197090961 268 dbSNP
rs774238213 271 dbSNP
rs1400665461 278 dbSNP
rs1273061529 279 dbSNP
rs770501401 283 dbSNP
rs1219266238 291 dbSNP
rs1388343360 291 dbSNP
rs968321530 293 dbSNP
rs910967527 298 dbSNP
rs1423242529 301 dbSNP
rs986546106 303 dbSNP
rs1474529729 308 dbSNP
rs1430331472 314 dbSNP
rs988413920 315 dbSNP
rs1169790255 317 dbSNP
rs956887154 322 dbSNP
rs1405301147 336 dbSNP
rs538202164 338 dbSNP
rs1367886527 339 dbSNP
rs918271141 362 dbSNP
rs972981643 380 dbSNP
rs1465102333 381 dbSNP
rs1377882703 387 dbSNP
rs1200521027 389 dbSNP
rs1324364366 391 dbSNP
rs757047024 397 dbSNP
rs181405279 400 dbSNP
rs552956164 407 dbSNP
rs534936816 408 dbSNP
rs1243721846 409 dbSNP
rs1484331408 413 dbSNP
rs879147842 423 dbSNP
rs1256011271 424 dbSNP
rs1259389358 427 dbSNP
rs1200012601 435 dbSNP
rs73417426 437 dbSNP
rs756134153 443 dbSNP
rs1014375088 447 dbSNP
rs1162250064 450 dbSNP
rs1328666035 451 dbSNP
rs1387692575 468 dbSNP
rs1425816968 479 dbSNP
rs1038653327 496 dbSNP
rs1383245494 499 dbSNP
rs1287501184 500 dbSNP
rs1383575366 502 dbSNP
rs1410190838 504 dbSNP
rs113701094 505 dbSNP
rs530208392 515 dbSNP
rs569420839 519 dbSNP
rs999414332 525 dbSNP
rs903770830 526 dbSNP
rs1043663207 533 dbSNP
rs1394993369 535 dbSNP
rs1043312 545 dbSNP
rs1239317490 550 dbSNP
rs1258750562 551 dbSNP
rs1439384844 555 dbSNP
rs1207154695 556 dbSNP
rs939084975 557 dbSNP
rs372842507 566 dbSNP
rs1173779809 569 dbSNP
rs926410312 572 dbSNP
rs369134679 573 dbSNP
rs376924365 575 dbSNP
rs1045233974 576 dbSNP
rs1160449150 580 dbSNP
rs946834811 584 dbSNP
rs1362429801 586 dbSNP
rs1455623680 586 dbSNP
rs1159485825 587 dbSNP
rs1401103452 589 dbSNP
rs1416393164 592 dbSNP
rs915420660 594 dbSNP
rs933748304 595 dbSNP
rs1258352121 596 dbSNP
rs918226172 599 dbSNP
rs972813517 603 dbSNP
rs1382806548 608 dbSNP
rs73417423 612 dbSNP
rs910129987 613 dbSNP
rs1337336015 618 dbSNP
rs980381858 621 dbSNP
rs1228819804 622 dbSNP
rs1330919628 626 dbSNP
rs1239567132 629 dbSNP
rs1255166879 635 dbSNP
rs1282162862 636 dbSNP
rs956997657 638 dbSNP
rs1265094609 639 dbSNP
rs1461773890 640 dbSNP
rs1177170084 642 dbSNP
rs1249094241 643 dbSNP
rs1421364954 650 dbSNP
rs1183070210 655 dbSNP
rs1429006405 656 dbSNP
rs970197870 660 dbSNP
rs917443722 665 dbSNP
rs1244013525 667 dbSNP
rs911879688 668 dbSNP
rs1340921517 669 dbSNP
rs1406210390 678 dbSNP
rs992895726 691 dbSNP
rs540549485 692 dbSNP
rs1031630627 698 dbSNP
rs1000600280 705 dbSNP
rs146613660 706 dbSNP
rs561317940 710 dbSNP
rs1022153973 717 dbSNP
rs36110716 719 dbSNP
rs994931867 722 dbSNP
rs962825345 723 dbSNP
rs542862478 726 dbSNP
rs1473417710 728 dbSNP
rs1249682750 734 dbSNP
rs1481940296 735 dbSNP
rs1006784748 737 dbSNP
rs1268627978 741 dbSNP
rs1191201665 750 dbSNP
rs1479636846 751 dbSNP
rs889593678 754 dbSNP
rs1429618638 758 dbSNP
rs1427529126 759 dbSNP
rs41274549 763 dbSNP
rs1355763918 764 dbSNP
rs997906477 765 dbSNP
rs1462446024 769 dbSNP
rs1248932105 770 dbSNP
rs1004514107 781 dbSNP
rs896895751 783 dbSNP
rs1303498503 786 dbSNP
rs1346460385 786 dbSNP
rs1467278587 800 dbSNP
rs1056043990 801 dbSNP
rs183781144 804 dbSNP
rs1309259831 814 dbSNP
rs941012434 815 dbSNP
rs946501569 821 dbSNP
rs915373685 822 dbSNP
rs1052642690 823 dbSNP
rs1485375977 824 dbSNP
rs1184344894 825 dbSNP
rs935558353 826 dbSNP
rs544716959 827 dbSNP
rs909574352 830 dbSNP
rs1225601852 836 dbSNP
rs577535760 847 dbSNP
rs948960894 848 dbSNP
rs1383348889 851 dbSNP
rs1426468249 857 dbSNP
rs1164036512 864 dbSNP
rs1363803548 866 dbSNP
rs1344325253 870 dbSNP
rs953318803 870 dbSNP
rs1287289565 871 dbSNP
rs550121266 880 dbSNP
rs1382894003 893 dbSNP
rs917386999 894 dbSNP
rs993405816 897 dbSNP
rs956270603 899 dbSNP
rs963511801 902 dbSNP
rs1292982181 903 dbSNP
rs924680828 905 dbSNP
rs552959087 906 dbSNP
rs1434758674 911 dbSNP
rs1379163259 914 dbSNP
rs1156398344 915 dbSNP
rs748901953 917 dbSNP
rs777207740 918 dbSNP
rs1186546580 920 dbSNP
rs755628765 923 dbSNP
rs1262465831 924 dbSNP
rs1017577659 925 dbSNP
rs867444362 928 dbSNP
rs1003423118 930 dbSNP
rs1006728920 933 dbSNP
rs1160989119 937 dbSNP
rs1486006324 939 dbSNP
rs41274547 940 dbSNP
rs772949903 941 dbSNP
rs1353077332 950 dbSNP
rs780570850 953 dbSNP
rs1274429771 957 dbSNP
rs1336229385 964 dbSNP
rs1244459761 968 dbSNP
rs374771065 969 dbSNP
rs1339112029 974 dbSNP
rs567591210 976 dbSNP
rs750804504 977 dbSNP
rs142956669 980 dbSNP
rs897016503 981 dbSNP
rs1401983324 990 dbSNP
rs757490603 992 dbSNP
rs935523946 994 dbSNP
rs1286773352 999 dbSNP
rs537195759 1007 dbSNP
rs1051980061 1010 dbSNP
rs1005326518 1018 dbSNP
rs1184157532 1022 dbSNP
rs1477452281 1026 dbSNP
rs1260991266 1027 dbSNP
rs1214513827 1035 dbSNP
rs569874651 1036 dbSNP
rs534313035 1040 dbSNP
rs921903952 1042 dbSNP
rs1285170519 1043 dbSNP
rs754075967 1048 dbSNP
rs1354621074 1055 dbSNP
rs1295488555 1061 dbSNP
rs888086054 1062 dbSNP
rs1175887044 1063 dbSNP
rs1048335680 1065 dbSNP
rs764126381 1065 dbSNP
rs1470970852 1072 dbSNP
rs1044090369 1082 dbSNP
rs1340420998 1093 dbSNP
rs1354512291 1097 dbSNP
rs948908983 1098 dbSNP
rs1418421444 1102 dbSNP
rs551068411 1106 dbSNP
rs539153256 1107 dbSNP
rs1222553825 1109 dbSNP
rs771828524 1111 dbSNP
rs1326509191 1112 dbSNP
rs527982754 1115 dbSNP
rs774939941 1116 dbSNP
rs917501184 1117 dbSNP
rs1403229849 1118 dbSNP
rs1396306532 1122 dbSNP
rs1165337578 1136 dbSNP
rs1057402581 1140 dbSNP
rs1174693411 1142 dbSNP
rs1464952550 1142 dbSNP
rs1365126476 1146 dbSNP
rs771590276 1150 dbSNP
rs181971700 1155 dbSNP
rs979230465 1167 dbSNP
rs947488041 1183 dbSNP
rs1233247557 1204 dbSNP
rs1479967672 1208 dbSNP
rs910513794 1209 dbSNP
rs1427524821 1210 dbSNP
rs986092839 1212 dbSNP
rs749708520 1214 dbSNP
rs770279101 1217 dbSNP
rs1173290412 1224 dbSNP
rs1418816991 1227 dbSNP
rs547013634 1228 dbSNP
rs1331408902 1239 dbSNP
rs1170618635 1252 dbSNP
rs1029981577 1255 dbSNP
rs775992156 1256 dbSNP
rs759990889 1260 dbSNP
rs1301641637 1271 dbSNP
rs1424806123 1272 dbSNP
rs745416866 1273 dbSNP
rs976721604 1277 dbSNP
rs369065797 1283 dbSNP
rs71319011 1284 dbSNP
rs778625144 1285 dbSNP
rs1269093852 1293 dbSNP
rs1479094941 1295 dbSNP
rs9835 1301 dbSNP
rs893546057 1306 dbSNP
rs1022758769 1307 dbSNP
rs1043441 1308 dbSNP
rs895511097 1310 dbSNP
rs1270775803 1314 dbSNP
rs563560218 1317 dbSNP
rs1490905138 1325 dbSNP
rs890597245 1327 dbSNP
rs544753685 1328 dbSNP
rs1057499923 1346 dbSNP
rs934946957 1362 dbSNP
rs903321491 1363 dbSNP
rs1043464 1366 dbSNP
rs1162128546 1367 dbSNP
rs1043233386 1376 dbSNP
rs1367784827 1388 dbSNP
rs1309924214 1389 dbSNP
rs1317147221 1401 dbSNP
rs777437912 1402 dbSNP
rs1432347088 1406 dbSNP
rs190578127 1407 dbSNP
rs1358728573 1410 dbSNP
rs372888995 1416 dbSNP
rs756082854 1417 dbSNP
rs17032 1429 dbSNP
rs1390972916 1433 dbSNP
rs148581450 1437 dbSNP
rs372117076 1439 dbSNP
rs78370268 1440 dbSNP
rs770877157 1441 dbSNP
rs923316833 1458 dbSNP
rs1444578355 1466 dbSNP
rs1182213376 1477 dbSNP
rs938787934 1478 dbSNP
rs1445982943 1488 dbSNP
rs1458690245 1489 dbSNP
rs528217660 1493 dbSNP
rs1158335771 1496 dbSNP
rs1382380490 1499 dbSNP
rs555659229 1503 dbSNP
rs927785078 1504 dbSNP
rs1358664384 1509 dbSNP
rs1334836177 1519 dbSNP
rs977048527 1522 dbSNP
rs185667988 1523 dbSNP
rs1015801788 1525 dbSNP
rs1317010080 1531 dbSNP
rs1238112297 1534 dbSNP
rs576284168 1534 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site CDS
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaUCCCUUGUGUCCCGACCACu 5'
            |||||    :| | ||||| 
Target 5' ccAGGGA----GGTGGTGGTGg 3'
 		9 - 26
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.69 4.5e-3 -0.493 4.3e-2 13 Click to see details
GSE28544 Breast cancer 0.376 3.5e-2 0.548 2.8e-3 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.293 8.7e-2 0.474 1.1e-2 23 Click to see details
GSE21687 Ependynoma primary tumors -0.152 1.2e-1 -0.206 5.1e-2 64 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.53 1.4e-1 -0.257 3.1e-1 6 Click to see details
GSE32688 Pancreatic cancer -0.187 1.5e-1 -0.179 1.6e-1 32 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.172 2.1e-1 0.348 4.4e-2 25 Click to see details
GSE38226 Liver fibrosis -0.145 2.7e-1 -0.167 2.3e-1 21 Click to see details
GSE17498 Multiple myeloma 0.053 3.7e-1 0.106 2.6e-1 40 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.07 3.8e-1 -0.460 2.1e-2 20 Click to see details
GSE26953 Aortic valvular endothelial cells 0.047 4.1e-1 0.102 3.2e-1 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.008 4.8e-1 -0.110 3.0e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LIHC -0.444 0 -0.533 0 41 Click to see details
KICH -0.559 0.01 -0.305 0.1 19 Click to see details
ESCA -0.817 0.01 -0.714 0.02 8 Click to see details
THCA -0.287 0.02 -0.252 0.03 54 Click to see details
COAD -0.766 0.02 -0.714 0.04 7 Click to see details
CHOL -0.803 0.03 -0.886 0.01 6 Click to see details
KIRC -0.235 0.04 -0.302 0.01 56 Click to see details
PCPG -0.978 0.07 -1.000 0.5 3 Click to see details
BLCA -0.318 0.13 -0.376 0.09 14 Click to see details
BRCA 0.136 0.14 0.116 0.18 66 Click to see details
HNSC -0.189 0.16 0.001 0.5 30 Click to see details
KIRP 0.112 0.27 0.070 0.35 32 Click to see details
LUAD 0.295 0.29 0.257 0.31 6 Click to see details
PRAD 0.089 0.34 0.123 0.28 25 Click to see details
LUSC -0.07 0.34 0.045 0.4 36 Click to see details
PAAD -0.238 0.38 -0.200 0.4 4 Click to see details
STAD -0.057 0.39 -0.111 0.29 27 Click to see details
UCEC 0.044 0.43 -0.037 0.44 19 Click to see details
UCEC 0.044 0.43 -0.037 0.44 19 Click to see details
UCEC 0.044 0.43 -0.037 0.44 19 Click to see details
UCEC 0.044 0.43 -0.037 0.44 19 Click to see details
210 hsa-miR-1226-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005492 MUC1 mucin 1, cell surface associated 3 1
MIRT036409 IGF1R insulin like growth factor 1 receptor 1 1
MIRT036410 UBE2A ubiquitin conjugating enzyme E2 A 1 1
MIRT036411 WDR1 WD repeat domain 1 1 1
MIRT036412 HIST1H4B histone cluster 1 H4 family member b 1 1
MIRT036413 BLMH bleomycin hydrolase 1 1
MIRT036414 HSPA1B heat shock protein family A (Hsp70) member 1B 1 1
MIRT036415 KDM2A lysine demethylase 2A 1 1
MIRT036416 RPL35 ribosomal protein L35 1 1
MIRT036417 KARS lysyl-tRNA synthetase 1 1
MIRT036418 AVL9 AVL9 cell migration associated 1 1
MIRT036419 GLUD2 glutamate dehydrogenase 2 1 1
MIRT036420 GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 1 1
MIRT036421 CABIN1 calcineurin binding protein 1 1 1
MIRT036422 LEPREL4 prolyl 3-hydroxylase family member 4 (non-enzymatic) 1 1
MIRT036423 CSDE1 cold shock domain containing E1 1 1
MIRT036424 UBE2G1 ubiquitin conjugating enzyme E2 G1 1 1
MIRT036425 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 1 1
MIRT036426 CCDC47 coiled-coil domain containing 47 1 1
MIRT036427 SCAMP1 secretory carrier membrane protein 1 1 1
MIRT036428 HSP90AA1 heat shock protein 90 alpha family class A member 1 1 1
MIRT036429 GIMAP8 GTPase, IMAP family member 8 1 1
MIRT036430 MBTPS2 membrane bound transcription factor peptidase, site 2 1 1
MIRT036431 RCC2 regulator of chromosome condensation 2 1 1
MIRT036432 DUT deoxyuridine triphosphatase 1 1
MIRT036433 XYLT2 xylosyltransferase 2 1 1
MIRT036434 SUN2 Sad1 and UNC84 domain containing 2 1 1
MIRT036435 SACS sacsin molecular chaperone 1 1
MIRT036436 C12orf29 chromosome 12 open reading frame 29 1 1
MIRT036437 PSMB2 proteasome subunit beta 2 1 1
MIRT036438 PAF1 PAF1 homolog, Paf1/RNA polymerase II complex component 1 1
MIRT036439 SCAMP4 secretory carrier membrane protein 4 1 1
MIRT036440 PIM2 Pim-2 proto-oncogene, serine/threonine kinase 1 1
MIRT036441 JUNB JunB proto-oncogene, AP-1 transcription factor subunit 1 1
MIRT036442 TBX18 T-box 18 1 1
MIRT036443 ACIN1 apoptotic chromatin condensation inducer 1 1 1
MIRT036444 CYB5B cytochrome b5 type B 1 1
MIRT036445 ATXN2 ataxin 2 1 1
MIRT036446 TBX3 T-box 3 1 1
MIRT036447 EPB41L1 erythrocyte membrane protein band 4.1 like 1 1 1
MIRT036448 TMEM25 transmembrane protein 25 1 1
MIRT036449 ZBTB4 zinc finger and BTB domain containing 4 1 1
MIRT036450 NDRG3 NDRG family member 3 1 1
MIRT036451 CPSF3L integrator complex subunit 11 1 1
MIRT036452 SORBS2 sorbin and SH3 domain containing 2 1 1
MIRT036453 RPA2 replication protein A2 1 1
MIRT036454 LONRF1 LON peptidase N-terminal domain and ring finger 1 1 1
MIRT036455 ZNF629 zinc finger protein 629 1 1
MIRT036456 NOP2 NOP2 nucleolar protein 1 1
MIRT036457 KIAA1644 KIAA1644 1 1
MIRT036458 HSPA9 heat shock protein family A (Hsp70) member 9 1 1
MIRT036459 ITPR3 inositol 1,4,5-trisphosphate receptor type 3 1 1
MIRT036460 TM9SF4 transmembrane 9 superfamily member 4 1 1
MIRT036461 SLC1A5 solute carrier family 1 member 5 1 1
MIRT036462 EXOC8 exocyst complex component 8 1 1
MIRT036463 ATP6AP2 ATPase H+ transporting accessory protein 2 1 1
MIRT036464 HIST1H4C histone cluster 1 H4 family member c 1 1
MIRT036465 ZDHHC4 zinc finger DHHC-type containing 4 1 1
MIRT036466 ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit 1 1
MIRT036467 LIMS1 LIM zinc finger domain containing 1 1 1
MIRT036468 RBM27 RNA binding motif protein 27 1 1
MIRT036469 EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase 1 1
MIRT036470 RABL6 RAB, member RAS oncogene family like 6 1 1
MIRT036471 RBM10 RNA binding motif protein 10 1 1
MIRT036472 RABGGTB Rab geranylgeranyltransferase beta subunit 1 1
MIRT036473 PFKL phosphofructokinase, liver type 1 1
MIRT036474 TOP2A DNA topoisomerase II alpha 1 1
MIRT036475 KIAA1671 KIAA1671 1 1
MIRT036476 EIF3C eukaryotic translation initiation factor 3 subunit C 1 1
MIRT036477 IPO7 importin 7 1 1
MIRT036478 CTDNEP1 CTD nuclear envelope phosphatase 1 1 1
MIRT036479 ZBTB7B zinc finger and BTB domain containing 7B 1 1
MIRT036480 GPBP1L1 GC-rich promoter binding protein 1 like 1 1 1
MIRT036481 PANK3 pantothenate kinase 3 1 1
MIRT036482 SLC35F6 solute carrier family 35 member F6 1 1
MIRT036483 RPL36A ribosomal protein L36a 1 1
MIRT036484 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1 1
MIRT036485 AKIP1 A-kinase interacting protein 1 1 1
MIRT036486 C1orf43 chromosome 1 open reading frame 43 1 1
MIRT036487 ACTG1 actin gamma 1 1 1
MIRT036488 EDC4 enhancer of mRNA decapping 4 1 1
MIRT036489 FTSJD2 cap methyltransferase 1 1 1
MIRT036490 GNB2L1 receptor for activated C kinase 1 1 1
MIRT036491 AP2M1 adaptor related protein complex 2 mu 1 subunit 1 1
MIRT036492 ASCC3 activating signal cointegrator 1 complex subunit 3 1 1
MIRT036493 PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha 1 1
MIRT036494 ZBTB40 zinc finger and BTB domain containing 40 1 1
MIRT036495 PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 1 1
MIRT036496 CTNNB1 catenin beta 1 1 1
MIRT036497 CEBPA CCAAT/enhancer binding protein alpha 1 1
MIRT036498 PKN3 protein kinase N3 1 1
MIRT036499 FAM3C family with sequence similarity 3 member C 1 1
MIRT036500 IDH1 isocitrate dehydrogenase (NADP(+)) 1, cytosolic 1 1
MIRT036501 CKAP4 cytoskeleton associated protein 4 1 1
MIRT036502 GCN1L1 GCN1, eIF2 alpha kinase activator homolog 1 1
MIRT036503 ASTL astacin like metalloendopeptidase 1 1
MIRT036504 ADAR adenosine deaminase, RNA specific 1 1
MIRT036505 IRAK1 interleukin 1 receptor associated kinase 1 1 1
MIRT036506 ALDH1B1 aldehyde dehydrogenase 1 family member B1 1 1
MIRT036507 HSPB8 heat shock protein family B (small) member 8 1 1
MIRT036508 MCM2 minichromosome maintenance complex component 2 1 1
MIRT036509 SGPL1 sphingosine-1-phosphate lyase 1 1 1
MIRT036510 SIMC1 SUMO interacting motifs containing 1 1 1
MIRT036511 PPIA peptidylprolyl isomerase A 1 1
MIRT036512 CENPF centromere protein F 1 1
MIRT036513 PRPF6 pre-mRNA processing factor 6 1 1
MIRT036514 CHD3 chromodomain helicase DNA binding protein 3 1 1
MIRT036515 PBRM1 polybromo 1 1 1
MIRT036516 USP24 ubiquitin specific peptidase 24 1 1
MIRT036517 UQCC ubiquinol-cytochrome c reductase complex assembly factor 1 1 1
MIRT036518 ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 2 3
MIRT036519 CNTNAP3 contactin associated protein like 3 1 1
MIRT036520 DDT D-dopachrome tautomerase 1 1
MIRT036521 ZNF395 zinc finger protein 395 1 1
MIRT036522 NDUFA5 NADH:ubiquinone oxidoreductase subunit A5 1 1
MIRT036523 SLC25A39 solute carrier family 25 member 39 1 1
MIRT036524 NCKIPSD NCK interacting protein with SH3 domain 1 1
MIRT036525 AAMP angio associated migratory cell protein 1 1
MIRT036526 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 1 1
MIRT036527 AGPAT6 glycerol-3-phosphate acyltransferase 4 1 1
MIRT036528 QPRT quinolinate phosphoribosyltransferase 1 1
MIRT036529 ABHD14B abhydrolase domain containing 14B 1 1
MIRT036530 BIRC5 baculoviral IAP repeat containing 5 1 1
MIRT036531 BAG6 BCL2 associated athanogene 6 1 1
MIRT036532 MRPS26 mitochondrial ribosomal protein S26 1 1
MIRT036533 KIF4B kinesin family member 4B 1 1
MIRT036534 TUBB4B tubulin beta 4B class IVb 1 1
MIRT036535 FAM168B family with sequence similarity 168 member B 1 1
MIRT036536 TUBB4A tubulin beta 4A class IVa 1 1
MIRT036537 AKR1B1 aldo-keto reductase family 1 member B 1 1
MIRT248779 ATXN7L3B ataxin 7 like 3B 2 2
MIRT279943 SLC39A9 solute carrier family 39 member 9 2 4
MIRT337171 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 4
MIRT443071 ABLIM1 actin binding LIM protein 1 2 2
MIRT451814 CDCA3 cell division cycle associated 3 2 2
MIRT467748 SLC36A1 solute carrier family 36 member 1 2 2
MIRT473511 MAZ MYC associated zinc finger protein 2 2
MIRT476233 GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2 2
MIRT486918 GPX1 glutathione peroxidase 1 2 2
MIRT489205 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT495363 AATF apoptosis antagonizing transcription factor 2 2
MIRT495390 VPS51 VPS51, GARP complex subunit 2 2
MIRT495594 ARHGEF28 Rho guanine nucleotide exchange factor 28 2 2
MIRT495692 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT495833 EHD1 EH domain containing 1 2 2
MIRT499765 CIRH1A UTP4, small subunit processome component 2 10
MIRT504903 CCDC86 coiled-coil domain containing 86 2 2
MIRT513211 RFT1 RFT1 homolog 2 2
MIRT519628 ZNF781 zinc finger protein 781 2 2
MIRT519843 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT530064 PLXNA4 plexin A4 2 2
MIRT531308 GPR26 G protein-coupled receptor 26 2 2
MIRT533268 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT534128 SNX13 sorting nexin 13 2 2
MIRT534291 SLAIN2 SLAIN motif family member 2 2 2
MIRT535866 MORF4L1 mortality factor 4 like 1 2 2
MIRT536022 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT539500 ACTN4 actinin alpha 4 2 2
MIRT547451 MBD4 methyl-CpG binding domain 4, DNA glycosylase 2 2
MIRT560019 ZNF525 zinc finger protein 525 2 2
MIRT560084 ZNF195 zinc finger protein 195 2 2
MIRT568722 GRASP general receptor for phosphoinositides 1 associated scaffold protein 2 2
MIRT570893 ZNF780A zinc finger protein 780A 2 2
MIRT571250 FADS6 fatty acid desaturase 6 2 2
MIRT573401 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT576568 Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 2 2
MIRT612131 NDUFA10 NADH:ubiquinone oxidoreductase subunit A10 2 2
MIRT613022 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT613861 TNFRSF9 TNF receptor superfamily member 9 2 4
MIRT614966 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 2
MIRT616581 FAM107A family with sequence similarity 107 member A 2 2
MIRT626205 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT640512 ANTXR1 anthrax toxin receptor 1 2 2
MIRT640536 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT641548 MOCOS molybdenum cofactor sulfurase 2 2
MIRT641683 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT642859 RNF135 ring finger protein 135 2 2
MIRT649106 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT651844 USP1 ubiquitin specific peptidase 1 2 2
MIRT659044 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659663 CDC73 cell division cycle 73 2 2
MIRT659959 CXCL10 C-X-C motif chemokine ligand 10 2 2
MIRT672556 BRMS1L breast cancer metastasis-suppressor 1 like 2 2
MIRT675601 ZNF106 zinc finger protein 106 2 2
MIRT676034 C9orf69 transmembrane protein 250 2 2
MIRT678691 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT682730 MSANTD1 Myb/SANT DNA binding domain containing 1 2 2
MIRT682993 RNF40 ring finger protein 40 2 2
MIRT687354 NUP98 nucleoporin 98 2 2
MIRT697178 INMT indolethylamine N-methyltransferase 2 2
MIRT698735 STX12 syntaxin 12 2 2
MIRT699632 SH3BP5 SH3 domain binding protein 5 2 2
MIRT704560 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT704708 CHEK1 checkpoint kinase 1 2 2
MIRT709863 PDIK1L PDLIM1 interacting kinase 1 like 2 2
MIRT712792 ZNF154 zinc finger protein 154 2 2
MIRT712918 MRGPRF MAS related GPR family member F 2 2
MIRT714040 ELMO1 engulfment and cell motility 1 2 2
MIRT714417 TBC1D16 TBC1 domain family member 16 2 2
MIRT714539 ZBTB39 zinc finger and BTB domain containing 39 2 2
MIRT715975 FADS3 fatty acid desaturase 3 2 2
MIRT716452 TMPRSS11BNL TMPRSS11B N-terminal like, pseudogene 2 2
MIRT716996 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT718745 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT719103 PCYT1A phosphate cytidylyltransferase 1, choline, alpha 2 2
MIRT721047 TRIM67 tripartite motif containing 67 2 2
MIRT721082 FTSJ2 mitochondrial rRNA methyltransferase 2 2 2
MIRT722291 PMPCA peptidase, mitochondrial processing alpha subunit 2 2
MIRT722940 NHP2L1 small nuclear ribonucleoprotein 13 2 2
MIRT725148 SLC43A1 solute carrier family 43 member 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1226 Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma tissue
hsa-mir-1226 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-1226 Androstenedione 6128 NSC9563 resistant cell line (MCF-7)
hsa-mir-1226 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-mir-1226 Cisplatin 5460033 NSC119875 approved sensitive cell line (KYSE)
hsa-mir-1226 Fluorouracil 3385 NSC19893 approved sensitive cell line (KYSE)
hsa-mir-1226 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-1226-3p Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-1226-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-1226-3p Fluorouracil 3385 NSC19893 approved sensitive High Esophageal Squamous Cell Carcinoma cell line (KYSE410)
hsa-miR-1226-3p Doxorubicin 31703 NSC123127 approved sensitive High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-1226-3p Aromatase Inhibitor resistant Low Breast Cancer cell line (MCF-7)
hsa-miR-1226-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-1226-3p Cisplatin 5460033 NSC119875 approved sensitive Low Esophageal Squamous Cell Carcinoma cell line (KYSE-70, KYSE-140, KYSE-180, KYSE-270, KYSE-410, KYSE-520)
hsa-miR-1226-3p Fluorouracil 3385 NSC19893 approved sensitive Low Esophageal Squamous Cell Carcinoma cell line (KYSE-70, KYSE-140, KYSE-180, KYSE-270, KYSE-410, KYSE-520)
hsa-miR-1226-3p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-1226-3p Sorafenib 216239 NSC747971 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2, SK-HEP-1)
hsa-miR-1226-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-1226-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1226-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-1226-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1226-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-miR-1226-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-1226-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM43)
hsa-miR-1226-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-1226-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-1226-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-1226-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (HS578T)
hsa-miR-1226-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-1226-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-1226-3p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-1226-3p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-1226-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-1226-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1226-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-1226-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (OVCAR3)
hsa-miR-1226-3p Cisplatin 5460033 NSC119875 approved resistant cell line (H460)

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