pre-miRNA Information
pre-miRNA hsa-mir-744   
Genomic Coordinates chr17: 12081899 - 12081996
Synonyms MIRN744, hsa-mir-744, MIR744
Description Homo sapiens miR-744 stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-744-5p
Sequence 11| UGCGGGGCUAGGGCUAACAGCA |32
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN23015028 1 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs557969425 1 dbSNP
rs748252260 4 dbSNP
rs1470408501 7 dbSNP
rs1178657616 10 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B6B8SM miR-744-5p Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Urine Real-time polymerase chain reaction
Gene Information
Gene Symbol ATP5S   
Synonyms ATPW, FB, HSU79253
Description ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B)
Transcript NM_001003805   
Other Transcripts NM_001003803 , NM_015684   
Expression
Putative miRNA Targets on ATP5S
3'UTR of ATP5S
(miRNA target sites are highlighted)
>ATP5S|NM_001003805|3'UTR
   1 GTGATCTTCCTGGAGTAAGAGAAAAAGAAAATCTTGTCCAAGCCTTTAAGACAGCACTGCCTTCTCTGGAACTAAAATTA
  81 CAATTGAAGTAAAATAATGTGTCTTATTTCAGTATAAAGGATCATTTGAAACTGTTGATTCCAAACATCAACTAATATTA
 161 TATAGTCATCAGTAGAATTATAAGGATGCCATATCATGACATTTTAGAAGTGGAGAGTGCATCATATGTAGAAAATAAAT
 241 ATTCAGACGTGGCTCATTAATGTTACTAAGTTGGAAGTGAGAATTTATGAACATTAATTCATTTTAAGAAAAGTGCAGCC
 321 AGGCGCAGTGGCTCATGCCTGTAATCCTAGCACTTTGGGAGGCCAAAGCGGGCAGATCACCTGAGGTCAGGAGTTCAAGA
 401 CCAACCATGGCCAACATGGTGAAACCCCATCTCTACTAAAAAAACAAAATTAGCTGAATGTGGTGGTGCACGCCTTTAAT
 481 CCCAGCTACTCTGGAGGCTGAGGCAGGAGAATCACTTGACTTGGGAGGTGGAGGTTGCAGGGACCCGAGATTGTGCCACT
 561 GCACTCCAGCCTGGGTGACAGAGCGAGACTGTCTCAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acGACA--AUCGGGA------UCGGGGCGu 5'
            :|||   ||||:|      ||| |:|| 
Target 5' tcTTGTCCAAGCCTTTAAGACAGCACTGCc 3'
32 - 61 108.00 -12.30
2
miRNA  3' acgacaaUCGGGAUCGG-GGCGu 5'
                 || ::  ||| |:|| 
Target 5' ggacccgAGATTGTGCCACTGCa 3'
541 - 563 95.00 -13.50
3
miRNA  3' acgACAAUCGGGA--UCGGGGCGu 5'
             ||   |||:|  | ||| || 
Target 5' tggTGCACGCCTTTAATCCCAGCt 3'
464 - 487 93.00 -14.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM4333132 4 COSMIC
COSM7615458 8 COSMIC
COSM956038 28 COSMIC
COSM7083475 32 COSMIC
COSM8917742 34 COSMIC
COSM6607982 60 COSMIC
COSM8771824 67 COSMIC
COSM3720921 78 COSMIC
COSM6309227 87 COSMIC
COSM80898 87 COSMIC
COSM5456436 91 COSMIC
COSN30167101 106 COSMIC
COSN30485867 190 COSMIC
COSN31486741 245 COSMIC
COSN22464974 482 COSMIC
COSN21793842 514 COSMIC
COSN16496024 629 COSMIC
COSN29576720 654 COSMIC
COSN23455468 1003 COSMIC
COSN8660129 1498 COSMIC
COSN16087008 1649 COSMIC
COSN17253021 1698 COSMIC
COSN23106493 1865 COSMIC
COSN16032048 2002 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs765080242 9 dbSNP
rs12839 12 dbSNP
rs368725017 16 dbSNP
rs777399185 19 dbSNP
rs748784549 28 dbSNP
rs112164857 34 dbSNP
rs922227062 37 dbSNP
rs774381451 39 dbSNP
rs745672927 40 dbSNP
rs140298574 47 dbSNP
rs771834416 51 dbSNP
rs1326671913 56 dbSNP
rs1261654896 57 dbSNP
rs775147044 62 dbSNP
rs1304591695 69 dbSNP
rs1380611453 82 dbSNP
rs369428246 84 dbSNP
rs1214481427 85 dbSNP
rs765359072 89 dbSNP
rs1326852613 90 dbSNP
rs1315032910 101 dbSNP
rs144057879 102 dbSNP
rs1313092777 107 dbSNP
rs1256028301 108 dbSNP
rs1450318167 113 dbSNP
rs1317232833 114 dbSNP
rs1019197167 116 dbSNP
rs766889535 121 dbSNP
rs752003281 124 dbSNP
rs1487292801 125 dbSNP
rs935955003 126 dbSNP
rs755299956 138 dbSNP
rs772523439 145 dbSNP
rs576036774 189 dbSNP
rs1359272235 191 dbSNP
rs187362588 199 dbSNP
rs1277177408 200 dbSNP
rs921588259 203 dbSNP
rs945428555 211 dbSNP
rs1343228119 214 dbSNP
rs1165070640 216 dbSNP
rs1444934239 218 dbSNP
rs1384040142 221 dbSNP
rs1042453710 225 dbSNP
rs535529629 227 dbSNP
rs906509480 229 dbSNP
rs1262992725 232 dbSNP
rs192264398 241 dbSNP
rs951887630 245 dbSNP
rs984520487 248 dbSNP
rs907607691 249 dbSNP
rs180857509 250 dbSNP
rs1238232574 256 dbSNP
rs77879028 262 dbSNP
rs547189951 268 dbSNP
rs895385155 291 dbSNP
rs776172576 293 dbSNP
rs1327105483 294 dbSNP
rs1017082357 296 dbSNP
rs1381635654 303 dbSNP
rs747630629 304 dbSNP
rs993896090 316 dbSNP
rs1424872627 317 dbSNP
rs1029841825 325 dbSNP
rs937211456 332 dbSNP
rs1463014951 334 dbSNP
rs1373167591 337 dbSNP
rs1193088553 338 dbSNP
rs1055553392 347 dbSNP
rs555619326 348 dbSNP
rs1271458491 354 dbSNP
rs985510554 362 dbSNP
rs1409104428 368 dbSNP
rs45586135 370 dbSNP
rs533095655 371 dbSNP
rs1034726364 374 dbSNP
rs185911677 378 dbSNP
rs140274537 386 dbSNP
rs1250896099 392 dbSNP
rs945901146 393 dbSNP
rs766201581 397 dbSNP
rs999673770 407 dbSNP
rs1316038736 408 dbSNP
rs1436439341 410 dbSNP
rs1019060223 412 dbSNP
rs978117810 415 dbSNP
rs1344640835 417 dbSNP
rs531630080 422 dbSNP
rs142078287 428 dbSNP
rs1392833969 434 dbSNP
rs996343175 435 dbSNP
rs1166851747 437 dbSNP
rs1396591607 437 dbSNP
rs1460898774 438 dbSNP
rs1029081777 439 dbSNP
rs1177829762 440 dbSNP
rs1279619837 444 dbSNP
rs1314151857 446 dbSNP
rs1480280140 449 dbSNP
rs951777919 460 dbSNP
rs939491489 462 dbSNP
rs1184241835 467 dbSNP
rs374028181 472 dbSNP
rs1262557155 473 dbSNP
rs1462735502 474 dbSNP
rs1264852948 478 dbSNP
rs895156727 484 dbSNP
rs774248237 488 dbSNP
rs1190456815 500 dbSNP
rs907640073 504 dbSNP
rs1322546906 509 dbSNP
rs961777026 518 dbSNP
rs759568650 529 dbSNP
rs1336038194 530 dbSNP
rs1327797642 547 dbSNP
rs1443889488 548 dbSNP
rs1407667758 559 dbSNP
rs375065534 560 dbSNP
rs1191490987 561 dbSNP
rs1426897154 564 dbSNP
rs928428851 567 dbSNP
rs868280707 570 dbSNP
rs897300354 571 dbSNP
rs1363397704 572 dbSNP
rs151168913 576 dbSNP
rs113015063 585 dbSNP
rs1204217432 586 dbSNP
rs1458325900 587 dbSNP
rs1460846213 588 dbSNP
rs1276217690 590 dbSNP
rs1206627947 594 dbSNP
rs749207326 595 dbSNP
rs776038172 595 dbSNP
rs1278524930 596 dbSNP
rs1320888337 596 dbSNP
rs1357883495 596 dbSNP
rs1452515681 596 dbSNP
rs1491186902 596 dbSNP
rs398025027 596 dbSNP
rs71118869 596 dbSNP
rs1325139987 600 dbSNP
rs1157034807 605 dbSNP
rs937244129 605 dbSNP
rs1446744950 606 dbSNP
rs1055682475 607 dbSNP
rs1183118690 609 dbSNP
rs540166229 609 dbSNP
rs1235629403 610 dbSNP
rs1370055153 610 dbSNP
rs1221887505 612 dbSNP
rs946778610 612 dbSNP
rs1282827933 613 dbSNP
rs1283376398 615 dbSNP
rs890866233 620 dbSNP
rs1361211185 624 dbSNP
rs1006672268 625 dbSNP
rs1244550059 633 dbSNP
rs1376348420 647 dbSNP
rs1272373778 648 dbSNP
rs868384611 653 dbSNP
rs1432181924 668 dbSNP
rs1326206443 669 dbSNP
rs375971812 671 dbSNP
rs1426761731 672 dbSNP
rs1366375237 675 dbSNP
rs116425757 677 dbSNP
rs990001495 678 dbSNP
rs1421759714 681 dbSNP
rs575960805 684 dbSNP
rs1446339548 689 dbSNP
rs1241279211 690 dbSNP
rs1222113873 691 dbSNP
rs1490788357 691 dbSNP
rs374964333 691 dbSNP
rs190157058 692 dbSNP
rs999539524 694 dbSNP
rs1221295614 703 dbSNP
rs1319388791 721 dbSNP
rs1248207509 726 dbSNP
rs1215637187 741 dbSNP
rs1339365084 743 dbSNP
rs1276880825 749 dbSNP
rs1020170437 752 dbSNP
rs1040540375 762 dbSNP
rs981679991 765 dbSNP
rs149907445 769 dbSNP
rs1356321464 775 dbSNP
rs1171279794 776 dbSNP
rs996738145 812 dbSNP
rs1409472053 814 dbSNP
rs939397964 825 dbSNP
rs1473297135 827 dbSNP
rs1481262137 828 dbSNP
rs1156291527 829 dbSNP
rs990925167 834 dbSNP
rs1190266274 840 dbSNP
rs377567904 841 dbSNP
rs1029284314 845 dbSNP
rs762552673 849 dbSNP
rs952376492 851 dbSNP
rs916546588 860 dbSNP
rs1005913800 863 dbSNP
rs1014569812 864 dbSNP
rs1324679168 866 dbSNP
rs941357376 870 dbSNP
rs571854789 872 dbSNP
rs540815766 878 dbSNP
rs117513134 886 dbSNP
rs1324702345 889 dbSNP
rs1283086532 891 dbSNP
rs533034731 895 dbSNP
rs958562038 896 dbSNP
rs930248502 901 dbSNP
rs370472521 907 dbSNP
rs1441481550 916 dbSNP
rs1398217707 927 dbSNP
rs1230367757 929 dbSNP
rs914520579 931 dbSNP
rs113426815 947 dbSNP
rs767539716 950 dbSNP
rs1406505940 952 dbSNP
rs78401946 966 dbSNP
rs923922559 980 dbSNP
rs935423541 982 dbSNP
rs1177432632 985 dbSNP
rs1011183128 990 dbSNP
rs1235892838 993 dbSNP
rs1040468111 1014 dbSNP
rs1489800882 1019 dbSNP
rs901931561 1026 dbSNP
rs1221390593 1027 dbSNP
rs1019948226 1028 dbSNP
rs967259457 1031 dbSNP
rs10133342 1036 dbSNP
rs531685296 1050 dbSNP
rs1362688224 1053 dbSNP
rs1035893462 1055 dbSNP
rs958585568 1058 dbSNP
rs991284507 1059 dbSNP
rs916656890 1064 dbSNP
rs1302225018 1068 dbSNP
rs962813004 1070 dbSNP
rs764277812 1074 dbSNP
rs1423144277 1075 dbSNP
rs1302906800 1076 dbSNP
rs113730157 1084 dbSNP
rs1444745117 1085 dbSNP
rs1255987026 1089 dbSNP
rs548340695 1094 dbSNP
rs1045886 1099 dbSNP
rs1487046309 1113 dbSNP
rs754102433 1133 dbSNP
rs568533881 1137 dbSNP
rs111453906 1138 dbSNP
rs897461690 1139 dbSNP
rs146476824 1140 dbSNP
rs1382133686 1141 dbSNP
rs111446193 1142 dbSNP
rs1128692 1143 dbSNP
rs958682282 1146 dbSNP
rs1015516833 1147 dbSNP
rs1363814850 1149 dbSNP
rs1245061829 1165 dbSNP
rs1275048918 1174 dbSNP
rs1399187606 1182 dbSNP
rs1358187332 1184 dbSNP
rs991368460 1199 dbSNP
rs1343921475 1200 dbSNP
rs571030844 1205 dbSNP
rs1165086705 1219 dbSNP
rs1342361792 1226 dbSNP
rs112034799 1231 dbSNP
rs1163288988 1235 dbSNP
rs1430849400 1237 dbSNP
rs968684652 1242 dbSNP
rs1041332092 1245 dbSNP
rs1487531763 1245 dbSNP
rs540056987 1256 dbSNP
rs1003182439 1257 dbSNP
rs1355718009 1259 dbSNP
rs1035626910 1263 dbSNP
rs958904500 1264 dbSNP
rs1012736151 1272 dbSNP
rs1309241484 1278 dbSNP
rs1442499898 1278 dbSNP
rs1188951694 1283 dbSNP
rs112774313 1288 dbSNP
rs924520852 1292 dbSNP
rs935371315 1300 dbSNP
rs112928084 1302 dbSNP
rs1463805594 1305 dbSNP
rs556778791 1310 dbSNP
rs1389346742 1322 dbSNP
rs918550915 1334 dbSNP
rs1463091530 1341 dbSNP
rs1374100339 1344 dbSNP
rs1202545954 1357 dbSNP
rs1166378223 1368 dbSNP
rs1170599342 1371 dbSNP
rs923385045 1374 dbSNP
rs570254769 1376 dbSNP
rs757351447 1387 dbSNP
rs1477013308 1391 dbSNP
rs932029352 1392 dbSNP
rs1431981628 1393 dbSNP
rs1050633508 1397 dbSNP
rs951431635 1399 dbSNP
rs887903807 1403 dbSNP
rs1265336486 1404 dbSNP
rs1197587020 1405 dbSNP
rs1415173777 1407 dbSNP
rs987429763 1413 dbSNP
rs1258562964 1421 dbSNP
rs1217994279 1422 dbSNP
rs1315831772 1433 dbSNP
rs942305227 1434 dbSNP
rs376139589 1444 dbSNP
rs1330098390 1450 dbSNP
rs182427567 1455 dbSNP
rs1002577828 1456 dbSNP
rs1035345911 1461 dbSNP
rs7147718 1466 dbSNP
rs1224882151 1468 dbSNP
rs139269206 1473 dbSNP
rs1013040610 1477 dbSNP
rs1021475314 1479 dbSNP
rs1376065402 1482 dbSNP
rs1184262992 1487 dbSNP
rs1419730626 1489 dbSNP
rs559076357 1500 dbSNP
rs1041467649 1501 dbSNP
rs1345266074 1506 dbSNP
rs190630091 1515 dbSNP
rs183619492 1517 dbSNP
rs544753631 1518 dbSNP
rs938349177 1523 dbSNP
rs1057227404 1543 dbSNP
rs1344039760 1554 dbSNP
rs1272660207 1555 dbSNP
rs1240817291 1557 dbSNP
rs894392468 1558 dbSNP
rs1460407016 1561 dbSNP
rs998629236 1566 dbSNP
rs1031591509 1569 dbSNP
rs577383734 1570 dbSNP
rs965258981 1573 dbSNP
rs976063492 1574 dbSNP
rs1400586712 1578 dbSNP
rs780536449 1579 dbSNP
rs953507223 1580 dbSNP
rs1379741991 1584 dbSNP
rs986592054 1588 dbSNP
rs1176802859 1591 dbSNP
rs1446552750 1602 dbSNP
rs909285868 1610 dbSNP
rs564929194 1621 dbSNP
rs995565469 1622 dbSNP
rs543261777 1630 dbSNP
rs1441620272 1631 dbSNP
rs1206498631 1637 dbSNP
rs1276328166 1637 dbSNP
rs942215581 1638 dbSNP
rs541892416 1644 dbSNP
rs527304439 1656 dbSNP
rs561658214 1664 dbSNP
rs1025746323 1675 dbSNP
rs1297245421 1688 dbSNP
rs1469321269 1690 dbSNP
rs1321145039 1697 dbSNP
rs1339042643 1699 dbSNP
rs112635475 1700 dbSNP
rs764149606 1703 dbSNP
rs772342450 1703 dbSNP
rs11295551 1704 dbSNP
rs1235502360 1704 dbSNP
rs1491098235 1704 dbSNP
rs398025028 1704 dbSNP
rs572873116 1704 dbSNP
rs75453465 1704 dbSNP
rs74332015 1706 dbSNP
rs1195007838 1717 dbSNP
rs938879605 1720 dbSNP
rs1056818197 1723 dbSNP
rs1331365041 1729 dbSNP
rs894106936 1734 dbSNP
rs1012679398 1738 dbSNP
rs1043224449 1744 dbSNP
rs1224939098 1747 dbSNP
rs1280914743 1754 dbSNP
rs1360966383 1763 dbSNP
rs904271608 1764 dbSNP
rs1290014146 1765 dbSNP
rs1228228715 1769 dbSNP
rs1354800819 1771 dbSNP
rs144862473 1778 dbSNP
rs1219557622 1784 dbSNP
rs1340312624 1788 dbSNP
rs374510361 1793 dbSNP
rs372205602 1796 dbSNP
rs188961144 1802 dbSNP
rs914719946 1806 dbSNP
rs1411488555 1807 dbSNP
rs1172743043 1809 dbSNP
rs1478016699 1812 dbSNP
rs1422736563 1814 dbSNP
rs1191016379 1816 dbSNP
rs1490752154 1822 dbSNP
rs1246946185 1827 dbSNP
rs1220135069 1828 dbSNP
rs1491533985 1828 dbSNP
rs1168209288 1829 dbSNP
rs1225560948 1829 dbSNP
rs1274521568 1829 dbSNP
rs1275653392 1829 dbSNP
rs1333275551 1829 dbSNP
rs1356408390 1829 dbSNP
rs1399243002 1829 dbSNP
rs1434316386 1829 dbSNP
rs1434717973 1829 dbSNP
rs1466111086 1829 dbSNP
rs1491189908 1829 dbSNP
rs555068519 1829 dbSNP
rs750138701 1829 dbSNP
rs758016227 1829 dbSNP
rs761957738 1829 dbSNP
rs773565273 1829 dbSNP
rs1190286368 1830 dbSNP
rs1476748774 1831 dbSNP
rs1203796679 1835 dbSNP
rs1261443444 1837 dbSNP
rs1434076692 1839 dbSNP
rs1201903815 1840 dbSNP
rs1427376821 1841 dbSNP
rs1239535015 1846 dbSNP
rs1179781450 1850 dbSNP
rs1457749841 1851 dbSNP
rs1480157612 1852 dbSNP
rs1205930092 1853 dbSNP
rs1313161269 1853 dbSNP
rs1159980248 1854 dbSNP
rs1365527477 1860 dbSNP
rs111657658 1861 dbSNP
rs1288120716 1862 dbSNP
rs1391214908 1867 dbSNP
rs1376008404 1870 dbSNP
rs1406499168 1872 dbSNP
rs1329232444 1879 dbSNP
rs1467336343 1884 dbSNP
rs548413212 1889 dbSNP
rs1174910792 1895 dbSNP
rs1412445239 1897 dbSNP
rs1381605027 1900 dbSNP
rs547880729 1916 dbSNP
rs370797512 1920 dbSNP
rs1228543097 1922 dbSNP
rs986130881 1929 dbSNP
rs1236818459 1931 dbSNP
rs909327541 1949 dbSNP
rs924368414 1950 dbSNP
rs1237303528 1954 dbSNP
rs938471446 1955 dbSNP
rs1260611322 1958 dbSNP
rs1056789840 1962 dbSNP
rs963448267 1965 dbSNP
rs948578095 1966 dbSNP
rs146766928 1969 dbSNP
rs1239430986 1975 dbSNP
rs1351615008 1977 dbSNP
rs533519564 1979 dbSNP
rs972232373 1980 dbSNP
rs1037638148 1983 dbSNP
rs1302098060 1984 dbSNP
rs550151473 1985 dbSNP
rs898968724 1987 dbSNP
rs1225108207 1991 dbSNP
rs149136376 1992 dbSNP
rs1490245503 1993 dbSNP
rs1418502976 1995 dbSNP
rs938931891 1997 dbSNP
rs1378013444 2005 dbSNP
rs1183030894 2006 dbSNP
rs1026175725 2007 dbSNP
rs887196560 2023 dbSNP
rs1008736823 2024 dbSNP
rs1057496981 2026 dbSNP
rs1180438317 2032 dbSNP
rs1489477057 2033 dbSNP
rs1264098671 2035 dbSNP
rs1216236793 2046 dbSNP
rs1487347097 2051 dbSNP
rs1417345841 2062 dbSNP
rs1158330741 2066 dbSNP
rs1267346470 2067 dbSNP
rs1019572564 2072 dbSNP
rs1322205655 2074 dbSNP
rs921287373 2076 dbSNP
rs964411244 2079 dbSNP
rs916150066 2080 dbSNP
rs948432133 2085 dbSNP
rs1042723858 2089 dbSNP
rs1358044328 2103 dbSNP
rs1294721975 2110 dbSNP
rs1457995401 2112 dbSNP
rs116849769 2113 dbSNP
rs769361970 2115 dbSNP
rs1478999566 2118 dbSNP
rs1424873103 2120 dbSNP
rs548940735 2127 dbSNP
rs565307234 2131 dbSNP
rs959780789 2134 dbSNP
rs1269767209 2157 dbSNP
rs900985995 2171 dbSNP
rs1488201944 2179 dbSNP
rs915554707 2182 dbSNP
rs193207924 2193 dbSNP
rs1319735511 2195 dbSNP
rs1337905642 2204 dbSNP
rs60103816 2204 dbSNP
rs894481777 2204 dbSNP
rs920491986 2213 dbSNP
rs1306928664 2217 dbSNP
rs929247002 2218 dbSNP
rs111985271 2219 dbSNP
rs890288823 2227 dbSNP
rs1389458573 2230 dbSNP
rs1292285257 2233 dbSNP
rs1248707539 2234 dbSNP
rs1008289575 2235 dbSNP
rs1401455562 2239 dbSNP
rs757380688 2245 dbSNP
rs749001770 2246 dbSNP
rs1379524189 2247 dbSNP
rs1359053914 2248 dbSNP
rs112533600 2249 dbSNP
rs770442036 2253 dbSNP
rs1265445625 2256 dbSNP
rs866918211 2257 dbSNP
rs1234777342 2258 dbSNP
rs1479700253 2262 dbSNP
rs1458994890 2268 dbSNP
rs899945479 2270 dbSNP
rs1197703945 2272 dbSNP
rs1176679518 2274 dbSNP
rs1257381629 2286 dbSNP
rs1233603730 2296 dbSNP
rs1243747859 2309 dbSNP
rs1016230666 2310 dbSNP
rs1181578742 2312 dbSNP
rs550272080 2321 dbSNP
rs963457635 2321 dbSNP
rs750496634 2323 dbSNP
rs972117712 2324 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 5'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acgacaaUCGGGAUCGGGG-CGu 5'
                 | ||| :||||| || 
Target 5' cgtctccATCCC-GGCCCCAGCc 3'
5 - 26
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38974 Chronic obstructive pulmonary disease 0.695 5.8e-5 0.687 7.4e-5 25 Click to see details
GSE26953 Aortic valvular endothelial cells 0.604 8.9e-4 0.510 5.4e-3 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.604 2.4e-3 0.612 2.1e-3 20 Click to see details
GSE19536 Breast cancer 0.217 1.5e-2 0.215 1.6e-2 100 Click to see details
GSE21687 Ependynoma primary tumors -0.258 2.0e-2 -0.163 9.9e-2 64 Click to see details
GSE42095 Differentiated embryonic stem cells -0.396 3.1e-2 -0.422 2.2e-2 23 Click to see details
GSE21032 Prostate cancer 0.196 3.8e-2 0.195 3.9e-2 83 Click to see details
GSE28544 Breast cancer -0.327 5.9e-2 -0.399 2.7e-2 24 Click to see details
GSE19783 ER- ER- breast cancer 0.164 7.4e-2 0.153 8.9e-2 79 Click to see details
GSE32688 Pancreatic cancer 0.234 9.9e-2 0.150 2.1e-1 32 Click to see details
GSE19350 CNS germ cell tumors 0.335 1.4e-1 0.385 1.1e-1 12 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.218 1.5e-1 0.337 5.0e-2 25 Click to see details
GSE19783 ER+ ER+ breast cancer 0.229 1.7e-1 0.185 2.2e-1 20 Click to see details
GSE38226 Liver fibrosis 0.18 2.2e-1 0.152 2.6e-1 21 Click to see details
GSE28260 Renal cortex and medulla 0.234 2.2e-1 0.302 1.6e-1 13 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.162 3.4e-1 -0.100 4.0e-1 9 Click to see details
GSE17498 Multiple myeloma -0.058 3.6e-1 -0.028 4.3e-1 40 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
PRAD -0.312 0.01 -0.277 0.03 50 Click to see details
BRCA 0.221 0.02 0.241 0.01 84 Click to see details
LUSC 0.228 0.08 0.232 0.08 38 Click to see details
CESC -0.965 0.08 -1.000 0.5 3 Click to see details
PAAD 0.797 0.1 0.600 0.2 4 Click to see details
COAD 0.469 0.12 0.190 0.33 8 Click to see details
BLCA 0.271 0.14 0.273 0.14 18 Click to see details
LIHC -0.137 0.17 -0.182 0.11 49 Click to see details
KICH -0.183 0.19 -0.308 0.07 25 Click to see details
THCA 0.09 0.25 0.097 0.23 59 Click to see details
KIRP -0.106 0.28 -0.168 0.18 32 Click to see details
CHOL 0.209 0.29 0.067 0.43 9 Click to see details
STAD 0.099 0.29 0.169 0.18 32 Click to see details
UCEC 0.122 0.31 0.158 0.26 19 Click to see details
LUAD 0.139 0.33 0.126 0.35 12 Click to see details
PCPG -0.4 0.37 -0.500 0.33 3 Click to see details
KIRC 0.029 0.41 0.108 0.19 68 Click to see details
ESCA -0.063 0.43 0.109 0.37 11 Click to see details
HNSC 0.007 0.48 0.091 0.28 42 Click to see details
HNSC 0.007 0.48 0.091 0.28 42 Click to see details
HNSC 0.007 0.48 0.091 0.28 42 Click to see details
412 hsa-miR-744-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT016085 ARL15 ADP ribosylation factor like GTPase 15 1 1
MIRT016086 AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 1 2
MIRT016087 PPTC7 PTC7 protein phosphatase homolog 2 3
MIRT016088 RASSF1 Ras association domain family member 1 1 1
MIRT016089 IER5 immediate early response 5 1 1
MIRT037383 UFC1 ubiquitin-fold modifier conjugating enzyme 1 1 1
MIRT037384 STAM2 signal transducing adaptor molecule 2 1 1
MIRT037385 SRRM2 serine/arginine repetitive matrix 2 1 1
MIRT037386 DCXR dicarbonyl and L-xylulose reductase 1 1
MIRT037387 TSPAN17 tetraspanin 17 1 1
MIRT037388 ACTB actin beta 1 1
MIRT037389 HIST1H2BC histone cluster 1 H2B family member c 1 1
MIRT037390 ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 1 1
MIRT037391 VDAC1 voltage dependent anion channel 1 1 1
MIRT037392 RNASEK ribonuclease K 1 1
MIRT037393 CDK16 cyclin dependent kinase 16 1 1
MIRT037394 ZCCHC24 zinc finger CCHC-type containing 24 1 1
MIRT037395 ARRDC2 arrestin domain containing 2 1 1
MIRT037396 SGMS1 sphingomyelin synthase 1 1 1
MIRT037397 HSPD1 heat shock protein family D (Hsp60) member 1 1 1
MIRT037398 MRPL46 mitochondrial ribosomal protein L46 1 1
MIRT037399 RHEB Ras homolog, mTORC1 binding 1 1
MIRT037400 ND1 NADH dehydrogenase, subunit 1 (complex I) 1 1
MIRT037401 TP53I13 tumor protein p53 inducible protein 13 1 1
MIRT037402 CD44 CD44 molecule (Indian blood group) 1 1
MIRT037403 USP12 ubiquitin specific peptidase 12 1 1
MIRT037404 AP2B1 adaptor related protein complex 2 beta 1 subunit 1 1
MIRT037405 RPL18A ribosomal protein L18a 1 1
MIRT037406 PPP1CA protein phosphatase 1 catalytic subunit alpha 1 1
MIRT037407 TNRC6B trinucleotide repeat containing 6B 1 1
MIRT037408 PXK PX domain containing serine/threonine kinase like 1 1
MIRT037409 TDRKH tudor and KH domain containing 1 1
MIRT037410 PRRC2A proline rich coiled-coil 2A 1 1
MIRT037411 ATP11A ATPase phospholipid transporting 11A 1 1
MIRT037412 NDE1 nudE neurodevelopment protein 1 1 1
MIRT037413 STK16 serine/threonine kinase 16 1 1
MIRT037414 PSMB2 proteasome subunit beta 2 1 1
MIRT037415 EPN1 epsin 1 1 1
MIRT037416 EN2 engrailed homeobox 2 1 1
MIRT037417 LARP1 La ribonucleoprotein domain family member 1 1 1
MIRT037418 SRCAP Snf2 related CREBBP activator protein 1 1
MIRT037419 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 1 1
MIRT037420 AP2A2 adaptor related protein complex 2 alpha 2 subunit 1 1
MIRT037421 ACTG1 actin gamma 1 1 1
MIRT037422 PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing 1 1
MIRT037423 UBE2O ubiquitin conjugating enzyme E2 O 1 1
MIRT037424 KLHL15 kelch like family member 15 1 1
MIRT037425 SECISBP2 SECIS binding protein 2 1 1
MIRT037426 KIAA0922 transmembrane 131 like 1 1
MIRT037427 PTMA prothymosin, alpha 1 1
MIRT037428 WDR45B WD repeat domain 45B 1 1
MIRT037429 ZNF282 zinc finger protein 282 1 1
MIRT037430 GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 1 1
MIRT037431 TNKS tankyrase 1 1
MIRT037432 NOP2 NOP2 nucleolar protein 1 1
MIRT037433 GAK cyclin G associated kinase 1 1
MIRT037434 ATP6 ATP synthase F0 subunit 6 1 1
MIRT037435 DIDO1 death inducer-obliterator 1 1 1
MIRT037436 RPL3 ribosomal protein L3 1 1
MIRT037437 AIMP2 aminoacyl tRNA synthetase complex interacting multifunctional protein 2 1 1
MIRT037438 PIGC phosphatidylinositol glycan anchor biosynthesis class C 1 1
MIRT037439 ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 1 1
MIRT037440 USP21 ubiquitin specific peptidase 21 1 1
MIRT037441 NUFIP2 NUFIP2, FMR1 interacting protein 2 1 1
MIRT037442 RPS6 ribosomal protein S6 1 1
MIRT037443 ILKAP ILK associated serine/threonine phosphatase 1 1
MIRT037444 COX1 cytochrome c oxidase subunit I 1 1
MIRT037445 VPS37C VPS37C, ESCRT-I subunit 1 1
MIRT037446 CDK12 cyclin dependent kinase 12 1 1
MIRT037447 RBM8A RNA binding motif protein 8A 1 1
MIRT037448 CKB creatine kinase B 1 1
MIRT037449 DHX57 DExH-box helicase 57 1 1
MIRT037450 DDX23 DEAD-box helicase 23 1 1
MIRT037451 ABI3 ABI family member 3 1 1
MIRT037452 GATAD2B GATA zinc finger domain containing 2B 1 1
MIRT037453 PDPK1 3-phosphoinositide dependent protein kinase 1 1 1
MIRT037454 C17orf70 Fanconi anemia core complex associated protein 100 1 1
MIRT037455 SKI SKI proto-oncogene 1 1
MIRT037456 KCTD11 potassium channel tetramerization domain containing 11 1 1
MIRT037457 GNB2L1 receptor for activated C kinase 1 1 1
MIRT037458 NCOA3 nuclear receptor coactivator 3 1 1
MIRT037459 PAK4 p21 (RAC1) activated kinase 4 2 3
MIRT037460 GDI2 GDP dissociation inhibitor 2 1 1
MIRT037461 SLC2A4RG SLC2A4 regulator 1 1
MIRT037462 SLX4 SLX4 structure-specific endonuclease subunit 1 1
MIRT037463 COPA coatomer protein complex subunit alpha 1 1
MIRT037464 GPRASP2 G protein-coupled receptor associated sorting protein 2 1 1
MIRT037465 GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 1 1
MIRT037466 LIMS1 LIM zinc finger domain containing 1 1 1
MIRT037467 COTL1 coactosin like F-actin binding protein 1 1 1
MIRT037468 CAPNS1 calpain small subunit 1 1 1
MIRT037469 FRZB frizzled-related protein 1 1
MIRT037470 UBQLN4 ubiquilin 4 1 1
MIRT037471 NUP153 nucleoporin 153 1 1
MIRT037472 TMEM175 transmembrane protein 175 1 1
MIRT037473 HIST1H2BD histone cluster 1 H2B family member d 1 1
MIRT037474 SREBF1 sterol regulatory element binding transcription factor 1 1 1
MIRT037475 BCL2L12 BCL2 like 12 1 1
MIRT037476 HIST2H2AA3 histone cluster 2 H2A family member a3 1 1
MIRT037477 MINK1 misshapen like kinase 1 1 1
MIRT037478 PDXK pyridoxal kinase 1 1
MIRT037479 FAM110A family with sequence similarity 110 member A 1 1
MIRT037480 ZNF598 zinc finger protein 598 1 1
MIRT037481 ILK integrin linked kinase 1 1
MIRT037482 HINT1 histidine triad nucleotide binding protein 1 1 1
MIRT037483 WBP2 WW domain binding protein 2 1 1
MIRT037484 CYTB cytochrome b 1 1
MIRT037485 SCAMP2 secretory carrier membrane protein 2 1 1
MIRT037486 TRIM33 tripartite motif containing 33 1 1
MIRT037487 SLC25A3 solute carrier family 25 member 3 1 1
MIRT037488 IRS4 insulin receptor substrate 4 1 1
MIRT037489 TSR1 TSR1, ribosome maturation factor 1 1
MIRT037490 TCOF1 treacle ribosome biogenesis factor 1 1 1
MIRT037491 ATXN2L ataxin 2 like 1 1
MIRT037492 MTOR mechanistic target of rapamycin kinase 1 1
MIRT037493 ZNF318 zinc finger protein 318 1 1
MIRT037494 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 3
MIRT037495 SAMD4B sterile alpha motif domain containing 4B 1 1
MIRT037496 STMN1 stathmin 1 1 1
MIRT037497 SAT1 spermidine/spermine N1-acetyltransferase 1 1 1
MIRT037498 SALL1 spalt like transcription factor 1 1 1
MIRT037499 ZSCAN18 zinc finger and SCAN domain containing 18 1 1
MIRT037500 SLC35D1 solute carrier family 35 member D1 1 1
MIRT037501 TM9SF3 transmembrane 9 superfamily member 3 1 1
MIRT037502 TIAM1 T-cell lymphoma invasion and metastasis 1 1 1
MIRT037503 CHD5 chromodomain helicase DNA binding protein 5 1 1
MIRT037504 BAG6 BCL2 associated athanogene 6 1 1
MIRT037505 MED28 mediator complex subunit 28 1 1
MIRT037506 ANKRD52 ankyrin repeat domain 52 1 1
MIRT037507 MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 1 1
MIRT037508 PPDPF pancreatic progenitor cell differentiation and proliferation factor 1 1
MIRT037509 PRKACA protein kinase cAMP-activated catalytic subunit alpha 1 1
MIRT037510 HPCAL4 hippocalcin like 4 1 1
MIRT037511 ZNF256 zinc finger protein 256 1 1
MIRT037512 CGNL1 cingulin like 1 1 1
MIRT037513 TUBA1B tubulin alpha 1b 1 1
MIRT037514 LNPEP leucyl and cystinyl aminopeptidase 1 1
MIRT037515 PDE4A phosphodiesterase 4A 1 1
MIRT037516 HOXD11 homeobox D11 2 3
MIRT037517 QARS glutaminyl-tRNA synthetase 1 1
MIRT037518 G3BP1 G3BP stress granule assembly factor 1 1 1
MIRT037519 PLEKHM2 pleckstrin homology and RUN domain containing M2 1 1
MIRT037520 POLR2A RNA polymerase II subunit A 1 1
MIRT037521 KIAA1462 junctional cadherin 5 associated 1 1
MIRT037522 SF3A1 splicing factor 3a subunit 1 1 1
MIRT037523 YBX1 Y-box binding protein 1 1 1
MIRT037524 PTGES3 prostaglandin E synthase 3 1 1
MIRT037525 FOXO3 forkhead box O3 1 1
MIRT037526 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 1 1
MIRT037527 AARS alanyl-tRNA synthetase 1 1
MIRT037528 ZNF155 zinc finger protein 155 1 1
MIRT037529 NCS1 neuronal calcium sensor 1 1 1
MIRT037530 FKBP4 FK506 binding protein 4 1 1
MIRT037531 ARHGDIA Rho GDP dissociation inhibitor alpha 1 1
MIRT037532 MAPK7 mitogen-activated protein kinase 7 1 1
MIRT037533 AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 1 1
MIRT037534 HIST1H1E histone cluster 1 H1 family member e 1 1
MIRT037535 MLF2 myeloid leukemia factor 2 1 1
MIRT037536 EDC3 enhancer of mRNA decapping 3 1 1
MIRT037537 CHRAC1 chromatin accessibility complex 1 1 1
MIRT037538 WIPF3 WAS/WASL interacting protein family member 3 1 1
MIRT037539 COX2 cytochrome c oxidase subunit II 1 1
MIRT037540 SRSF1 serine and arginine rich splicing factor 1 1 1
MIRT037541 CTNNBIP1 catenin beta interacting protein 1 1 1
MIRT037542 RPL4 ribosomal protein L4 1 1
MIRT037543 COX3 cytochrome c oxidase III 1 1
MIRT037544 DDX54 DEAD-box helicase 54 1 1
MIRT037545 TOB2 transducer of ERBB2, 2 1 1
MIRT037546 MAN2C1 mannosidase alpha class 2C member 1 1 1
MIRT037547 SMCR7L mitochondrial elongation factor 1 1 1
MIRT037548 RPLP1 ribosomal protein lateral stalk subunit P1 1 1
MIRT037549 RAN RAN, member RAS oncogene family 1 1
MIRT037550 NONO non-POU domain containing octamer binding 1 1
MIRT037551 CYB5R3 cytochrome b5 reductase 3 1 1
MIRT037552 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 1 1
MIRT037553 COLGALT1 collagen beta(1-O)galactosyltransferase 1 1 1
MIRT037554 MGRN1 mahogunin ring finger 1 1 1
MIRT037555 ANAPC1 anaphase promoting complex subunit 1 1 1
MIRT037556 TBX1 T-box 1 1 1
MIRT037557 NXPH4 neurexophilin 4 1 1
MIRT037558 HSPA1B heat shock protein family A (Hsp70) member 1B 1 1
MIRT037559 UBE2A ubiquitin conjugating enzyme E2 A 1 1
MIRT037560 KPNB1 karyopherin subunit beta 1 1 1
MIRT037561 NDUFB10 NADH:ubiquinone oxidoreductase subunit B10 1 1
MIRT037562 SYMPK symplekin 1 1
MIRT037563 SYPL1 synaptophysin like 1 1 1
MIRT037564 LRP3 LDL receptor related protein 3 1 1
MIRT037565 DDX24 DEAD-box helicase 24 1 1
MIRT037566 WDR37 WD repeat domain 37 1 1
MIRT037567 RPS14 ribosomal protein S14 1 1
MIRT037568 FAM53C family with sequence similarity 53 member C 1 1
MIRT037569 NMT1 N-myristoyltransferase 1 1 1
MIRT037570 PAGR1 PAXIP1 associated glutamate rich protein 1 1 1
MIRT037571 AKT2 AKT serine/threonine kinase 2 1 1
MIRT037572 TMEM14C transmembrane protein 14C 1 1
MIRT037573 MEX3D mex-3 RNA binding family member D 1 1
MIRT037574 BRAF B-Raf proto-oncogene, serine/threonine kinase 1 1
MIRT037575 POLR2L RNA polymerase II subunit L 1 1
MIRT037576 SERP1 stress associated endoplasmic reticulum protein 1 1 1
MIRT037577 C8orf33 chromosome 8 open reading frame 33 1 1
MIRT037578 NR1D2 nuclear receptor subfamily 1 group D member 2 1 1
MIRT037579 POLD3 DNA polymerase delta 3, accessory subunit 1 1
MIRT037580 HMGA1 high mobility group AT-hook 1 1 1
MIRT037581 SLC35B4 solute carrier family 35 member B4 1 1
MIRT037582 PELP1 proline, glutamate and leucine rich protein 1 1 1
MIRT037583 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 1 1
MIRT037584 RPL7A ribosomal protein L7a 1 1
MIRT037585 LAIR1 leukocyte associated immunoglobulin like receptor 1 1 1
MIRT037586 RPL10 ribosomal protein L10 1 1
MIRT037587 MRPS16 mitochondrial ribosomal protein S16 1 1
MIRT037588 SRM spermidine synthase 1 1
MIRT037589 EIF3K eukaryotic translation initiation factor 3 subunit K 1 1
MIRT037590 DESI1 desumoylating isopeptidase 1 1 1
MIRT037591 BET1 Bet1 golgi vesicular membrane trafficking protein 1 1
MIRT037592 HTRA2 HtrA serine peptidase 2 1 1
MIRT037593 LARP6 La ribonucleoprotein domain family member 6 1 1
MIRT037594 NOTCH2 notch 2 1 1
MIRT037595 ADCY9 adenylate cyclase 9 1 1
MIRT037596 C6orf62 chromosome 6 open reading frame 62 1 1
MIRT037597 FBXL19 F-box and leucine rich repeat protein 19 1 1
MIRT037598 L3MBTL2 L3MBTL2, polycomb repressive complex 1 subunit 1 1
MIRT037599 TRIM28 tripartite motif containing 28 1 1
MIRT037600 LGALS3 galectin 3 1 1
MIRT037601 IGSF8 immunoglobulin superfamily member 8 1 1
MIRT037602 LIN37 lin-37 DREAM MuvB core complex component 1 1
MIRT037603 PTPRF protein tyrosine phosphatase, receptor type F 1 1
MIRT037604 MTSS1L MTSS1L, I-BAR domain containing 1 1
MIRT037605 TRMT2A tRNA methyltransferase 2 homolog A 1 1
MIRT037606 DVL1 dishevelled segment polarity protein 1 1 1
MIRT037607 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 1 1
MIRT037608 TOR2A torsin family 2 member A 1 1
MIRT037609 RPS6KA5 ribosomal protein S6 kinase A5 1 1
MIRT037610 SMYD4 SET and MYND domain containing 4 1 1
MIRT037611 TJAP1 tight junction associated protein 1 1 1
MIRT037612 IRAK1 interleukin 1 receptor associated kinase 1 1 1
MIRT037613 PPM1M protein phosphatase, Mg2+/Mn2+ dependent 1M 1 1
MIRT037614 EIF4A2 eukaryotic translation initiation factor 4A2 1 1
MIRT037615 GFER growth factor, augmenter of liver regeneration 1 1
MIRT037616 PKP2 plakophilin 2 1 1
MIRT037617 FARSB phenylalanyl-tRNA synthetase beta subunit 1 1
MIRT037618 OPRD1 opioid receptor delta 1 1 1
MIRT037619 CCNY cyclin Y 1 1
MIRT037620 CNOT1 CCR4-NOT transcription complex subunit 1 1 1
MIRT037621 CXCL16 C-X-C motif chemokine ligand 16 1 1
MIRT037622 CEBPA CCAAT/enhancer binding protein alpha 1 1
MIRT037623 DDX11 DEAD/H-box helicase 11 1 1
MIRT037624 URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 1 1
MIRT037625 SBF1 SET binding factor 1 1 1
MIRT037626 GNB2 G protein subunit beta 2 1 1
MIRT037627 KMT2D lysine methyltransferase 2D 2 3
MIRT037628 DDX17 DEAD-box helicase 17 1 1
MIRT037629 SORBS3 sorbin and SH3 domain containing 3 1 1
MIRT037630 TAPBP TAP binding protein 1 1
MIRT037631 BCR BCR, RhoGEF and GTPase activating protein 1 1
MIRT037632 RPL18 ribosomal protein L18 1 1
MIRT037633 INTS3 integrator complex subunit 3 1 1
MIRT037634 CDC25B cell division cycle 25B 1 1
MIRT037635 LDOC1L retrotransposon Gag like 6 1 1
MIRT037636 TUB tubby bipartite transcription factor 1 1
MIRT037637 NUDT2 nudix hydrolase 2 1 1
MIRT037638 CDAN1 codanin 1 1 1
MIRT037639 MRS2 MRS2, magnesium transporter 1 1
MIRT037640 PYGB glycogen phosphorylase B 1 1
MIRT037641 LDLRAD3 low density lipoprotein receptor class A domain containing 3 1 1
MIRT037642 COL5A1 collagen type V alpha 1 chain 1 1
MIRT037643 ATF7IP activating transcription factor 7 interacting protein 1 1
MIRT037644 AGO1 argonaute 1, RISC catalytic component 1 1
MIRT037645 ZNF212 zinc finger protein 212 1 1
MIRT037646 TSC2 TSC complex subunit 2 1 1
MIRT037647 FASN fatty acid synthase 1 1
MIRT037648 NOL9 nucleolar protein 9 1 1
MIRT037649 CLUH clustered mitochondria homolog 1 1
MIRT037650 PHF8 PHD finger protein 8 1 1
MIRT037651 EIF4G1 eukaryotic translation initiation factor 4 gamma 1 1 1
MIRT037652 TRAPPC12 trafficking protein particle complex 12 1 1
MIRT037653 HOXC11 homeobox C11 1 1
MIRT037654 DGCR14 ess-2 splicing factor homolog 1 1
MIRT037655 SLC25A1 solute carrier family 25 member 1 1 1
MIRT037656 MEX3C mex-3 RNA binding family member C 1 1
MIRT037657 RAI1 retinoic acid induced 1 1 1
MIRT037658 LY6E lymphocyte antigen 6 family member E 1 1
MIRT037659 SEC16A SEC16 homolog A, endoplasmic reticulum export factor 1 1
MIRT037660 RPL37 ribosomal protein L37 1 1
MIRT037661 CNN2 calponin 2 1 1
MIRT037662 ALDH18A1 aldehyde dehydrogenase 18 family member A1 1 1
MIRT037663 POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 1 1
MIRT037664 EIF4A1 eukaryotic translation initiation factor 4A1 1 1
MIRT037665 PIM3 Pim-3 proto-oncogene, serine/threonine kinase 1 1
MIRT037666 PTPMT1 protein tyrosine phosphatase, mitochondrial 1 1 1
MIRT037667 NCEH1 neutral cholesterol ester hydrolase 1 1 1
MIRT037668 ART5 ADP-ribosyltransferase 5 1 1
MIRT037669 MRPS2 mitochondrial ribosomal protein S2 1 1
MIRT037670 NCL nucleolin 1 1
MIRT037671 NCKAP5L NCK associated protein 5 like 1 1
MIRT037672 ZCCHC14 zinc finger CCHC-type containing 14 1 1
MIRT037673 CCDC71 coiled-coil domain containing 71 1 1
MIRT037674 SURF4 surfeit 4 1 1
MIRT037675 RPL13 ribosomal protein L13 1 1
MIRT037676 ACTN4 actinin alpha 4 1 1
MIRT037677 PA2G4 proliferation-associated 2G4 1 1
MIRT037678 MIF macrophage migration inhibitory factor 1 1
MIRT037679 UBE2N ubiquitin conjugating enzyme E2 N 1 1
MIRT037680 LYNX1 Ly6/neurotoxin 1 1 1
MIRT037681 TACC3 transforming acidic coiled-coil containing protein 3 1 1
MIRT037682 GSR glutathione-disulfide reductase 1 1
MIRT037683 GSK3A glycogen synthase kinase 3 alpha 1 1
MIRT037684 ZMYM3 zinc finger MYM-type containing 3 1 1
MIRT037685 ERP29 endoplasmic reticulum protein 29 1 1
MIRT037686 MATR3 matrin 3 1 1
MIRT037687 FANCG Fanconi anemia complementation group G 1 1
MIRT037688 FAM83G family with sequence similarity 83 member G 1 1
MIRT037689 DUSP18 dual specificity phosphatase 18 1 1
MIRT037690 MYC MYC proto-oncogene, bHLH transcription factor 3 2
MIRT037691 TSPAN7 tetraspanin 7 1 1
MIRT037692 ATMIN ATM interactor 1 1
MIRT037693 SEPT2 septin 2 1 1
MIRT037694 FOXRED2 FAD dependent oxidoreductase domain containing 2 1 1
MIRT037695 TECR trans-2,3-enoyl-CoA reductase 1 1
MIRT037696 MRPL11 mitochondrial ribosomal protein L11 1 1
MIRT037697 IP6K1 inositol hexakisphosphate kinase 1 1 1
MIRT037698 PSMD4 proteasome 26S subunit, non-ATPase 4 1 1
MIRT037699 SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 1 1
MIRT037700 CTNNB1 catenin beta 1 1 1
MIRT037701 TMEM189 transmembrane protein 189 1 1
MIRT037702 LDLR low density lipoprotein receptor 1 1
MIRT037703 OGFR opioid growth factor receptor 1 1
MIRT037704 ADAP2 ArfGAP with dual PH domains 2 1 1
MIRT037705 LIPA lipase A, lysosomal acid type 1 1
MIRT037706 SNAPC4 small nuclear RNA activating complex polypeptide 4 1 1
MIRT037707 FBN2 fibrillin 2 1 1
MIRT037708 ZNF704 zinc finger protein 704 1 1
MIRT037709 EIF3M eukaryotic translation initiation factor 3 subunit M 1 1
MIRT037710 SMC1A structural maintenance of chromosomes 1A 1 1
MIRT037711 FZR1 fizzy and cell division cycle 20 related 1 1 1
MIRT037712 NANOS1 nanos C2HC-type zinc finger 1 1 1
MIRT037713 PRR12 proline rich 12 1 1
MIRT037714 PHC2 polyhomeotic homolog 2 1 1
MIRT037715 NOP9 NOP9 nucleolar protein 1 1
MIRT037716 HM13 histocompatibility minor 13 1 1
MIRT037717 PRDX5 peroxiredoxin 5 1 1
MIRT037718 IRGQ immunity related GTPase Q 1 1
MIRT037719 TGFB1 transforming growth factor beta 1 7 2
MIRT037720 MARCH3 membrane associated ring-CH-type finger 3 1 1
MIRT037721 TBX2 T-box 2 1 1
MIRT037722 TSC22D3 TSC22 domain family member 3 1 1
MIRT037723 DUT deoxyuridine triphosphatase 1 1
MIRT037724 FAM171A2 family with sequence similarity 171 member A2 1 1
MIRT037725 FGFR1 fibroblast growth factor receptor 1 1 1
MIRT037726 FRAT1 FRAT1, WNT signaling pathway regulator 1 1
MIRT037727 PSMD11 proteasome 26S subunit, non-ATPase 11 1 1
MIRT037728 PABPC1 poly(A) binding protein cytoplasmic 1 1 1
MIRT037729 ENO1 enolase 1 1 1
MIRT037730 AP3D1 adaptor related protein complex 3 delta 1 subunit 1 1
MIRT037731 TUBA1A tubulin alpha 1a 1 1
MIRT037732 ULK3 unc-51 like kinase 3 1 1
MIRT037733 PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha 1 1
MIRT037734 SLC25A46 solute carrier family 25 member 46 1 1
MIRT037735 MED15 mediator complex subunit 15 1 1
MIRT037736 IRF2BP1 interferon regulatory factor 2 binding protein 1 1 1
MIRT037737 UBA1 ubiquitin like modifier activating enzyme 1 1 1
MIRT037738 ATHL1 protein-glucosylgalactosylhydroxylysine glucosidase 1 1
MIRT037739 CTNNA1 catenin alpha 1 1 1
MIRT037740 ADRM1 adhesion regulating molecule 1 1 1
MIRT037741 CCDC106 coiled-coil domain containing 106 1 1
MIRT054493 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 3 1
MIRT451195 PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 2 2
MIRT452931 DISC1 disrupted in schizophrenia 1 2 2
MIRT455468 LYPLA2 lysophospholipase II 2 2
MIRT457068 TOR4A torsin family 4 member A 2 2
MIRT464195 VGLL4 vestigial like family member 4 2 4
MIRT483030 KHSRP KH-type splicing regulatory protein 2 4
MIRT486062 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT486120 INO80E INO80 complex subunit E 2 2
MIRT486866 DPF1 double PHD fingers 1 2 2
MIRT488343 PAX2 paired box 2 2 2
MIRT488790 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT490249 MFI2 melanotransferrin 2 2
MIRT490264 HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2 2
MIRT490756 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT492321 SETD1B SET domain containing 1B 2 2
MIRT492851 NRGN neurogranin 2 2
MIRT499604 ANKRD45 ankyrin repeat domain 45 2 2
MIRT500189 BARX1 BARX homeobox 1 2 4
MIRT516765 FAM212B family with sequence similarity 212 member B 2 4
MIRT517949 TRIM59 tripartite motif containing 59 2 2
MIRT521182 SCAF4 SR-related CTD associated factor 4 2 2
MIRT526462 OSBPL5 oxysterol binding protein like 5 2 2
MIRT535148 PLEKHG5 pleckstrin homology and RhoGEF domain containing G5 2 2
MIRT569528 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 2
MIRT570593 NFIX nuclear factor I X 2 2
MIRT571219 F2R coagulation factor II thrombin receptor 2 2
MIRT574145 MARVELD1 MARVEL domain containing 1 2 2
MIRT608758 CACNA1A calcium voltage-gated channel subunit alpha1 A 2 2
MIRT649509 RAB17 RAB17, member RAS oncogene family 2 2
MIRT692165 RNF207 ring finger protein 207 2 2
MIRT703495 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT711081 NEUROD2 neuronal differentiation 2 2 2
MIRT712090 UNC13A unc-13 homolog A 2 2
MIRT712531 CYTH2 cytohesin 2 2 2
MIRT712755 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT712893 TGFA transforming growth factor alpha 2 2
MIRT714684 PRX periaxin 2 2
MIRT714723 VPS8 VPS8, CORVET complex subunit 2 2
MIRT714814 NOB1 NIN1/PSMD8 binding protein 1 homolog 2 2
MIRT716774 C1orf229 chromosome 1 open reading frame 229 2 2
MIRT717511 HRNR hornerin 2 2
MIRT717653 THBS2 thrombospondin 2 2 2
MIRT719595 PIAS4 protein inhibitor of activated STAT 4 2 2
MIRT720525 PTGR2 prostaglandin reductase 2 2 2
MIRT724925 VPS18 VPS18, CORVET/HOPS core subunit 2 2
MIRT737146 NOS3 nitric oxide synthase 3 1 0
MIRT756003 SLC7A5 solute carrier family 7 member 5 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-744 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-744 Tert-butyl hydroperoxide (t-BHP) NULL 6410 Microarray mouse auditory cells 20510889 2010 up-regulated
miR-744 Ursodeoxycholic acid (UDCA) approved 31401 Microarray rat Liver 20689055 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-744 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901)
hsa-mir-744 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-744 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-744 Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-mir-744 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-744 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-744 Cisplatin 5460033 NSC119875 approved resistant cell line (SGC-7901)
hsa-miR-744-5p [1,1'-binaphthalene]-2,2',3,3'-tetrol 316673 NSC245006 sensitive
hsa-miR-744-5p 4-n-[12-[(5-amino-6-chloropyrimidin-4-yl)amino]dodecyl]-6-chloropyrimidine-4,5-diamine 358989 NSC619196 sensitive
hsa-miR-744-5p 5,7-dibromo-2-[(e)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]quinolin-8-ol 135460261 NSC67090 sensitive
hsa-miR-744-5p Benzyl 2-(dibenzylamino)-3-phenylpropanoate 375616 NSC655438 sensitive
hsa-miR-744-5p N'-[(Z)-[(4Z)-2-(1,3-benzodioxol-5-yl)-4-[[4-oxo-4-[2-(trifluoromethyl)anilino]butanoyl]hydrazinylidene]chromen-3-ylidene]amino]-N-[2-(trifluoromethyl)phenyl]butanediamide 6399328 NSC641210 sensitive
hsa-miR-744-5p Paullone analog 47 396411 NSC702373 sensitive
hsa-miR-744-5p Ursa-11,13(18)-dien-28-oic acid-3.beta.-ol 378695 NSC661747 sensitive
hsa-miR-744-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7, LY2)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3)
hsa-miR-744-5p Carboplatin 38904 NSC241240 approved sensitive High Ovarian Cancer tissue and cell line (MDAH-2274, SKOV3)
hsa-miR-744-5p Gefitinib 123631 NSC715055 approved resistant High Lung Adenocarcinoma cell line (A549)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved sensitive High Esophageal Squamous Cell Carcinoma cell line (KYSE410)
hsa-miR-744-5p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-744-5p Vinorelbine 44424639 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-744-5p Epirubicin 41867 NSC256942 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-744-5p Erlotinib 176870 NSC718781 approved sensitive High Non-Small Cell Lung Cancer tissue
hsa-miR-744-5p Gefitinib 123631 NSC715055 approved sensitive High Non-Small Cell Lung Cancer tissue
hsa-miR-744-5p Sunitinib 5329102 NSC750690 approved sensitive High Renal Cell Cancer tissue
hsa-miR-744-5p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-744-5p Sorafenib 216239 NSC747971 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901, BGC-823)
hsa-miR-744-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Colorectal Cancer cell line (HCT-116)
hsa-miR-744-5p Bortezomib 387447 NSC681239 approved sensitive Low Multiple Myeloma tissue
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-744-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-744-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-744-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-744-5p Fluorouracil 3385 NSC19893 approved sensitive cell line (HCT15)
hsa-miR-744-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-744-5p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-744-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-744-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-744-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-744-5p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-744-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-744-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-744-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-744-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (H23)

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