pre-miRNA Information
pre-miRNA hsa-mir-744   
Genomic Coordinates chr17: 12081899 - 12081996
Synonyms MIRN744, hsa-mir-744, MIR744
Description Homo sapiens miR-744 stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-744-5p
Sequence 11| UGCGGGGCUAGGGCUAACAGCA |32
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN23015028 1 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs557969425 1 dbSNP
rs748252260 4 dbSNP
rs1470408501 7 dbSNP
rs1178657616 10 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B6B8SM miR-744-5p Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Urine Real-time polymerase chain reaction
Gene Information
Gene Symbol PYGB   
Synonyms GPBB
Description glycogen phosphorylase B
Transcript NM_002862   
Expression
Putative miRNA Targets on PYGB
3'UTR of PYGB
(miRNA target sites are highlighted)
>PYGB|NM_002862|3'UTR
   1 GCACACCCTGCCTTGGCGGGACCAGCGGGCATTTGTTTTCTTGCTGACTTTGCACCTCCTTTTTTCCCCAAACACTTTGC
  81 CAGCCACTGGTGGTCCCTGCTTTTCTGAGTACCATGTTTCCAGGAGGGGCCATGGGGGTCAGGGTGGTTTTGAGAGAGCA
 161 GGGTAAGGAAGGAATGTGCTAGAAGTGCTCCTAGTTTCTTGTAAAGGAAGCCAGAGTTGACAGTACAAAGGGTCGTGGCC
 241 AGCCCTGCAGCTTCAGCACCTGCCCCACCCAGAGTGGGAGTCAGGTGGAGCCACCTGCTGGGCTCCCCCAGAACTTTGCA
 321 CACATCTTGCTATGTATTAGCCGATGTCTTTAGTGTTGAGCCTCTGGATTCTGGGGTCTGGGCCAGTGGCCATAGTGAAG
 401 CCTGGGAATGAGTGTTACTGCAGCATCTGGGCTGCCAGCCACAGGGAAGGGCCAAGCCCCATGTAGCCCCAGTCATCCTG
 481 CCCAGCCCTGCCTCCTGGCCATGCCGGGAGGGGTCGGATCCTCTAGGCATCGCCTTCACAGCCCCCTGCCCCCTGCCCTC
 561 TGTCCTGGCTCTGCACCTGGTATATGGGTCATGGACCCAGATGGGGCTTTCCCTTTGTAGCCATCCAATGGGCATTGTGT
 641 GGGTGCTTGGAACCCGGGATGACTGAGGGGGACACTGGAGTGGGTGCTTGTGTCTGCTGTCTCAGAGGCCTTGGTCAGGA
 721 TGAAGTTGGCTGACACAGCTTAGCTTGGTTTTGCTTATTCAAAAGAGAAAATAACTACACATGGAAATGAAACTAGCTGA
 801 AGCCTTTTCTTGTTTTAGCAACTGAAAATTGTACTTGGTCACTTTTGTGCTTGAGGAGGCCCATTTTCTGCCTGGCAGGG
 881 GGCAGGTCTGTGCCCTCCCGCTGACTCCTGCTGTGTCCTGAGGTGCATTTCCTGTTGTACACACAAGGGCCAGGCTCCAT
 961 TCTCCCTCCCTTTCCACCAGTGCCACAGCCTCGTCTGGAAAAAGGACCAGGGGTCCCGGAGGAACCCATTTGTGCTCTGC
1041 TTGGACAGCAGGCCTGGCACTGGGAGGTGGGGGTGAGCCCCTCACAGCCTTGCCCCTCCCCAAGGCTGGCAACCTGCCTC
1121 CCATTGCCCAAGAGAGAGGGCAGGGAACAGGCTACTGTCCTTCCCTGTGGAATTGCCGAGAAATCTAGCACCTTGCATGC
1201 TGGATCTGGGCTGCGGGGAGGCTCTTTTTCTCCCTGGCCTCCAGTGCCCACCAGGAGGATCTGCGCACGGTGCACAGCCC
1281 ACCAGAGCACTACAGCCTTTTATTGAGTGGGGCAAGTGCTGGGCTGTGGTCGTGCCCTGACAGCATCTTCCCCAGGCAGC
1361 GGCTCTGTGGAGGAGGCCATACTCCCCTAGTTGGCCACTGGGGCCACCACCCTGACCACCACTGTGCCCCTCATTGTTAC
1441 TGCCTTGTGAGATAAAAACTGATTAAACCTTTGTGGCTGTGGTTGGCTGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acgacaauCGGGAUCGGGGCGu 5'
                  |||| |||||:|| 
Target 5' gtcatcctGCCC-AGCCCTGCc 3'
472 - 492 141.00 -20.50
2
miRNA  3' acgacaAUCGGGAUCGGGGCGu 5'
                |:|||  |||||:|| 
Target 5' gggtcgTGGCC--AGCCCTGCa 3'
230 - 249 140.00 -20.70
3
miRNA  3' acGAC---AAUCGGGAUCGGGGCGu 5'
            |||   |  |:|||:||:|:|| 
Target 5' ccCTGCCCTCTGTCCTGGCTCTGCa 3'
551 - 575 132.00 -24.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24306993 9 COSMIC
COSN30522346 18 COSMIC
COSN30509032 19 COSMIC
COSN28891229 22 COSMIC
COSN30520582 57 COSMIC
COSN26991177 66 COSMIC
COSN23015482 112 COSMIC
COSN31534075 124 COSMIC
COSN8610633 153 COSMIC
COSN26592668 454 COSMIC
COSN7998028 745 COSMIC
COSN15933028 748 COSMIC
COSN30134873 843 COSMIC
COSN22063612 1255 COSMIC
COSN20116360 1313 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1280580029 5 dbSNP
rs1472759674 6 dbSNP
rs201916087 7 dbSNP
rs780792104 12 dbSNP
rs745519628 18 dbSNP
rs199901904 19 dbSNP
rs779839022 20 dbSNP
rs748510041 21 dbSNP
rs1310016548 23 dbSNP
rs200991582 27 dbSNP
rs202098395 28 dbSNP
rs749231664 30 dbSNP
rs200109245 31 dbSNP
rs1429242479 36 dbSNP
rs919101544 40 dbSNP
rs770926149 41 dbSNP
rs776621848 42 dbSNP
rs929115100 43 dbSNP
rs1265580335 44 dbSNP
rs759603088 51 dbSNP
rs1202598439 53 dbSNP
rs1423842168 55 dbSNP
rs1239626817 60 dbSNP
rs1185601226 66 dbSNP
rs1189743655 69 dbSNP
rs200841416 71 dbSNP
rs1257851618 72 dbSNP
rs41282340 74 dbSNP
rs1479390384 76 dbSNP
rs948759950 79 dbSNP
rs1035971166 86 dbSNP
rs9927 87 dbSNP
rs904645439 88 dbSNP
rs1000288218 90 dbSNP
rs1357732908 92 dbSNP
rs1294156345 93 dbSNP
rs1053164781 94 dbSNP
rs201712231 96 dbSNP
rs202155672 97 dbSNP
rs1394425815 100 dbSNP
rs570364649 108 dbSNP
rs998334056 114 dbSNP
rs200330727 115 dbSNP
rs1349293383 116 dbSNP
rs1162677523 117 dbSNP
rs1476078405 127 dbSNP
rs201108202 129 dbSNP
rs188832447 133 dbSNP
rs375020215 135 dbSNP
rs954409645 139 dbSNP
rs985813650 140 dbSNP
rs910320630 143 dbSNP
rs145042596 145 dbSNP
rs1380564931 146 dbSNP
rs1382192225 148 dbSNP
rs1273159507 155 dbSNP
rs1017276513 156 dbSNP
rs201286188 159 dbSNP
rs1276356760 161 dbSNP
rs1228029344 164 dbSNP
rs1334262402 165 dbSNP
rs199568690 166 dbSNP
rs1392086266 168 dbSNP
rs147078003 172 dbSNP
rs371271089 172 dbSNP
rs200669669 181 dbSNP
rs1394966221 183 dbSNP
rs202015775 185 dbSNP
rs1451358054 194 dbSNP
rs1311338077 200 dbSNP
rs1207786068 207 dbSNP
rs73343097 208 dbSNP
rs1046319047 211 dbSNP
rs200516357 212 dbSNP
rs201678685 214 dbSNP
rs1260400836 219 dbSNP
rs199977018 220 dbSNP
rs1192309533 223 dbSNP
rs201125215 227 dbSNP
rs202175497 235 dbSNP
rs191766656 236 dbSNP
rs935962644 249 dbSNP
rs1413080078 251 dbSNP
rs1053216996 255 dbSNP
rs1301272490 264 dbSNP
rs947527102 269 dbSNP
rs1043284902 273 dbSNP
rs903352304 289 dbSNP
rs1371728976 290 dbSNP
rs999477845 293 dbSNP
rs201069491 295 dbSNP
rs1380359116 299 dbSNP
rs577638354 302 dbSNP
rs376520305 304 dbSNP
rs1030595351 310 dbSNP
rs1342378785 313 dbSNP
rs202211637 315 dbSNP
rs200376699 319 dbSNP
rs1282832035 322 dbSNP
rs1392739205 325 dbSNP
rs1051267799 328 dbSNP
rs1365796931 331 dbSNP
rs1454327374 331 dbSNP
rs183892826 333 dbSNP
rs201699404 334 dbSNP
rs1007152993 336 dbSNP
rs1312625377 339 dbSNP
rs200280321 343 dbSNP
rs201185344 344 dbSNP
rs963138509 346 dbSNP
rs199776001 352 dbSNP
rs1488955931 354 dbSNP
rs898855552 358 dbSNP
rs200245809 359 dbSNP
rs1348660973 360 dbSNP
rs201407533 361 dbSNP
rs950594978 362 dbSNP
rs1225098643 369 dbSNP
rs199665352 376 dbSNP
rs1327981138 379 dbSNP
rs1026050438 385 dbSNP
rs1395223950 391 dbSNP
rs1476822306 397 dbSNP
rs1192622500 400 dbSNP
rs982415926 401 dbSNP
rs200767074 402 dbSNP
rs1314297650 409 dbSNP
rs1434850126 412 dbSNP
rs1388971873 415 dbSNP
rs927928227 419 dbSNP
rs201927795 421 dbSNP
rs199585314 423 dbSNP
rs573905844 425 dbSNP
rs542939619 427 dbSNP
rs200617277 430 dbSNP
rs1194428935 435 dbSNP
rs202025722 438 dbSNP
rs200135524 439 dbSNP
rs991519133 444 dbSNP
rs1418870729 447 dbSNP
rs993109376 449 dbSNP
rs1213224584 450 dbSNP
rs761084604 450 dbSNP
rs1272292177 452 dbSNP
rs201089148 462 dbSNP
rs1341456182 463 dbSNP
rs1270693039 466 dbSNP
rs201660832 467 dbSNP
rs1353306475 468 dbSNP
rs200012246 471 dbSNP
rs200958376 473 dbSNP
rs980061406 475 dbSNP
rs201892692 483 dbSNP
rs936014757 484 dbSNP
rs1411154675 486 dbSNP
rs1348259575 492 dbSNP
rs1399315062 497 dbSNP
rs1168977680 500 dbSNP
rs528302731 501 dbSNP
rs1416088013 505 dbSNP
rs200220651 506 dbSNP
rs201041203 507 dbSNP
rs1232501944 508 dbSNP
rs202212900 512 dbSNP
rs200500134 516 dbSNP
rs201397518 517 dbSNP
rs879275547 524 dbSNP
rs1212936348 525 dbSNP
rs913356649 532 dbSNP
rs199560060 533 dbSNP
rs1372244071 534 dbSNP
rs6083795 535 dbSNP
rs1277381457 539 dbSNP
rs1051584071 541 dbSNP
rs1443808048 541 dbSNP
rs1332662860 543 dbSNP
rs934863507 544 dbSNP
rs1355722959 549 dbSNP
rs200321694 550 dbSNP
rs1392749311 551 dbSNP
rs889976333 553 dbSNP
rs942840430 556 dbSNP
rs1157022016 557 dbSNP
rs1407581297 557 dbSNP
rs1471211849 558 dbSNP
rs564623954 559 dbSNP
rs890742071 560 dbSNP
rs201436579 561 dbSNP
rs1467128326 562 dbSNP
rs1007177451 564 dbSNP
rs1214144928 568 dbSNP
rs1223231624 569 dbSNP
rs1281734630 570 dbSNP
rs199819733 570 dbSNP
rs1225077189 574 dbSNP
rs767746313 578 dbSNP
rs1301987619 583 dbSNP
rs1457562457 584 dbSNP
rs200510961 585 dbSNP
rs201687769 586 dbSNP
rs898844237 587 dbSNP
rs1437691688 589 dbSNP
rs1382597237 594 dbSNP
rs994518989 596 dbSNP
rs199668988 597 dbSNP
rs1381138060 598 dbSNP
rs1173168809 601 dbSNP
rs1452625284 603 dbSNP
rs950589304 604 dbSNP
rs200834663 606 dbSNP
rs373743683 608 dbSNP
rs898739425 611 dbSNP
rs994497387 613 dbSNP
rs981998526 621 dbSNP
rs1440824265 622 dbSNP
rs75685904 629 dbSNP
rs756100189 630 dbSNP
rs202085052 636 dbSNP
rs199918488 637 dbSNP
rs200869260 638 dbSNP
rs1349389180 639 dbSNP
rs915878009 640 dbSNP
rs1163573683 645 dbSNP
rs201519976 648 dbSNP
rs1220276762 650 dbSNP
rs200137449 654 dbSNP
rs201008370 656 dbSNP
rs201997124 657 dbSNP
rs1433321768 658 dbSNP
rs1324391633 663 dbSNP
rs1312478321 665 dbSNP
rs200432068 666 dbSNP
rs924742457 670 dbSNP
rs1176715242 671 dbSNP
rs548508698 672 dbSNP
rs201184485 673 dbSNP
rs1427786531 675 dbSNP
rs1417275619 676 dbSNP
rs1188117028 680 dbSNP
rs1478006312 681 dbSNP
rs1354195071 682 dbSNP
rs202163870 691 dbSNP
rs200228766 694 dbSNP
rs886067188 698 dbSNP
rs1280332878 705 dbSNP
rs201341841 708 dbSNP
rs1307490034 709 dbSNP
rs569949607 711 dbSNP
rs1294023252 713 dbSNP
rs1051976829 714 dbSNP
rs6115132 719 dbSNP
rs535789113 721 dbSNP
rs753945479 726 dbSNP
rs1341469199 737 dbSNP
rs1292944108 738 dbSNP
rs202114172 739 dbSNP
rs200502686 750 dbSNP
rs549275405 752 dbSNP
rs1303552388 754 dbSNP
rs1378905018 761 dbSNP
rs1491404892 761 dbSNP
rs1491199954 762 dbSNP
rs1465964045 764 dbSNP
rs774197353 770 dbSNP
rs1185350212 772 dbSNP
rs201409304 781 dbSNP
rs199566079 782 dbSNP
rs943590190 785 dbSNP
rs1256416037 788 dbSNP
rs1176167322 790 dbSNP
rs1479360115 794 dbSNP
rs1353579704 795 dbSNP
rs1024450678 800 dbSNP
rs1207197822 802 dbSNP
rs1272886602 804 dbSNP
rs200805998 804 dbSNP
rs1039275630 809 dbSNP
rs1290101943 814 dbSNP
rs767219586 814 dbSNP
rs1802896 819 dbSNP
rs1032961055 823 dbSNP
rs1313667387 829 dbSNP
rs1316889898 829 dbSNP
rs898813076 829 dbSNP
rs8183962 830 dbSNP
rs771448712 831 dbSNP
rs1047924416 832 dbSNP
rs1196426161 835 dbSNP
rs188223720 838 dbSNP
rs534910307 839 dbSNP
rs199825528 841 dbSNP
rs557894647 844 dbSNP
rs1447339512 845 dbSNP
rs1393473786 847 dbSNP
rs180713603 848 dbSNP
rs1003782148 850 dbSNP
rs200469948 852 dbSNP
rs913242089 853 dbSNP
rs1157855246 854 dbSNP
rs148983514 857 dbSNP
rs556964683 858 dbSNP
rs1473794474 861 dbSNP
rs200039878 869 dbSNP
rs779241636 872 dbSNP
rs200801761 875 dbSNP
rs6115133 879 dbSNP
rs202090023 881 dbSNP
rs1163877706 883 dbSNP
rs1418954057 884 dbSNP
rs6115134 886 dbSNP
rs201199333 887 dbSNP
rs778202928 889 dbSNP
rs911280270 893 dbSNP
rs202110697 894 dbSNP
rs1315203547 895 dbSNP
rs200110189 900 dbSNP
rs1240960746 901 dbSNP
rs200846309 902 dbSNP
rs1370208743 903 dbSNP
rs377562510 906 dbSNP
rs1323785013 907 dbSNP
rs1442862926 908 dbSNP
rs942913231 909 dbSNP
rs968687156 911 dbSNP
rs898791831 918 dbSNP
rs369449659 919 dbSNP
rs1447268140 920 dbSNP
rs202019918 932 dbSNP
rs1333377542 935 dbSNP
rs1338664580 937 dbSNP
rs1450177699 938 dbSNP
rs573543990 939 dbSNP
rs745413049 943 dbSNP
rs1316822128 945 dbSNP
rs1347183235 956 dbSNP
rs769121385 963 dbSNP
rs1014318860 965 dbSNP
rs1045513069 974 dbSNP
rs956110562 976 dbSNP
rs1291490223 979 dbSNP
rs1380311885 982 dbSNP
rs987969401 986 dbSNP
rs200434404 988 dbSNP
rs201487903 990 dbSNP
rs768639613 993 dbSNP
rs143739159 994 dbSNP
rs200223376 997 dbSNP
rs1276997149 1002 dbSNP
rs1172319251 1003 dbSNP
rs1039244529 1009 dbSNP
rs1378705657 1009 dbSNP
rs1188919325 1010 dbSNP
rs201118954 1014 dbSNP
rs1262557758 1016 dbSNP
rs1192970912 1017 dbSNP
rs199705997 1018 dbSNP
rs200675322 1019 dbSNP
rs1217574760 1022 dbSNP
rs201284820 1023 dbSNP
rs1278217618 1026 dbSNP
rs199565904 1035 dbSNP
rs760005045 1036 dbSNP
rs1250656832 1040 dbSNP
rs1010172699 1044 dbSNP
rs1342087398 1045 dbSNP
rs1171750227 1047 dbSNP
rs200813779 1052 dbSNP
rs1399862359 1053 dbSNP
rs141982565 1057 dbSNP
rs1353034826 1059 dbSNP
rs201817562 1060 dbSNP
rs35739540 1069 dbSNP
rs1047427032 1071 dbSNP
rs200171542 1078 dbSNP
rs200647287 1080 dbSNP
rs201683910 1081 dbSNP
rs1279651700 1083 dbSNP
rs1340712195 1089 dbSNP
rs1232136679 1091 dbSNP
rs1426145688 1097 dbSNP
rs563763028 1101 dbSNP
rs964474383 1102 dbSNP
rs374010589 1104 dbSNP
rs7018 1104 dbSNP
rs752779715 1105 dbSNP
rs1201456298 1107 dbSNP
rs760820629 1117 dbSNP
rs7019 1121 dbSNP
rs1319741218 1123 dbSNP
rs1450806349 1124 dbSNP
rs1218931724 1125 dbSNP
rs949780519 1126 dbSNP
rs1332311189 1130 dbSNP
rs1285568816 1131 dbSNP
rs1448152180 1132 dbSNP
rs3210009 1133 dbSNP
rs35325816 1142 dbSNP
rs202159865 1145 dbSNP
rs967991026 1146 dbSNP
rs1328779262 1148 dbSNP
rs187294811 1149 dbSNP
rs1432798657 1155 dbSNP
rs1403073391 1156 dbSNP
rs1171919361 1157 dbSNP
rs201161778 1164 dbSNP
rs1802897 1165 dbSNP
rs905487196 1166 dbSNP
rs528743802 1167 dbSNP
rs764235280 1168 dbSNP
rs754151959 1174 dbSNP
rs202083577 1178 dbSNP
rs190439618 1179 dbSNP
rs1375716907 1184 dbSNP
rs200745668 1186 dbSNP
rs1174128548 1192 dbSNP
rs201696752 1194 dbSNP
rs571744574 1198 dbSNP
rs1291621380 1203 dbSNP
rs1049744 1207 dbSNP
rs1417827687 1208 dbSNP
rs537191094 1210 dbSNP
rs1277326320 1212 dbSNP
rs181745719 1214 dbSNP
rs200280130 1215 dbSNP
rs1299471678 1216 dbSNP
rs1332610881 1217 dbSNP
rs1440651708 1218 dbSNP
rs201187143 1219 dbSNP
rs1385117426 1221 dbSNP
rs567320900 1222 dbSNP
rs1385869812 1225 dbSNP
rs920839996 1226 dbSNP
rs1333127453 1232 dbSNP
rs955465384 1234 dbSNP
rs199820292 1235 dbSNP
rs930874118 1240 dbSNP
rs567231521 1246 dbSNP
rs1407513442 1250 dbSNP
rs1156967712 1254 dbSNP
rs1441586986 1254 dbSNP
rs984118867 1256 dbSNP
rs1192886473 1257 dbSNP
rs17173299 1262 dbSNP
rs200232389 1265 dbSNP
rs201525619 1266 dbSNP
rs147361834 1269 dbSNP
rs200773198 1270 dbSNP
rs573204159 1271 dbSNP
rs894926489 1272 dbSNP
rs1353733850 1273 dbSNP
rs1488237124 1275 dbSNP
rs947861987 1277 dbSNP
rs1310664262 1283 dbSNP
rs201924587 1284 dbSNP
rs199583513 1291 dbSNP
rs545321271 1293 dbSNP
rs999419560 1295 dbSNP
rs200618125 1296 dbSNP
rs1453075362 1300 dbSNP
rs201776654 1304 dbSNP
rs111759013 1307 dbSNP
rs75048118 1307 dbSNP
rs16438 1308 dbSNP
rs386393579 1309 dbSNP
rs201492201 1310 dbSNP
rs1172951207 1312 dbSNP
rs1431424491 1312 dbSNP
rs397742519 1313 dbSNP
rs200921977 1314 dbSNP
rs201921762 1315 dbSNP
rs199976602 1318 dbSNP
rs1474945316 1319 dbSNP
rs1240021199 1324 dbSNP
rs558759648 1330 dbSNP
rs200956605 1332 dbSNP
rs137886008 1333 dbSNP
rs951576863 1336 dbSNP
rs200223804 1338 dbSNP
rs1018976523 1339 dbSNP
rs1262642252 1340 dbSNP
rs1361650290 1344 dbSNP
rs1276545821 1349 dbSNP
rs964802175 1351 dbSNP
rs1402015407 1352 dbSNP
rs1392474454 1355 dbSNP
rs1312420189 1356 dbSNP
rs1464579715 1357 dbSNP
rs1360871028 1361 dbSNP
rs200849155 1362 dbSNP
rs1421126488 1366 dbSNP
rs202086871 1366 dbSNP
rs1195420068 1368 dbSNP
rs1331076362 1369 dbSNP
rs1477978334 1369 dbSNP
rs1179648552 1375 dbSNP
rs1483934713 1376 dbSNP
rs1045285774 1377 dbSNP
rs563654692 1379 dbSNP
rs1449649065 1380 dbSNP
rs1310636870 1383 dbSNP
rs1321138582 1384 dbSNP
rs200544904 1385 dbSNP
rs529313893 1386 dbSNP
rs952327572 1392 dbSNP
rs1318919138 1400 dbSNP
rs983698809 1403 dbSNP
rs1292878671 1405 dbSNP
rs1394383427 1406 dbSNP
rs1381371687 1410 dbSNP
rs908144953 1411 dbSNP
rs1441322599 1412 dbSNP
rs1267345318 1413 dbSNP
rs115790381 1415 dbSNP
rs1465919346 1418 dbSNP
rs1198315064 1423 dbSNP
rs1416781602 1423 dbSNP
rs1162202793 1427 dbSNP
rs561151055 1427 dbSNP
rs1413811213 1432 dbSNP
rs186939175 1437 dbSNP
rs779426754 1441 dbSNP
rs1236850179 1442 dbSNP
rs7020 1443 dbSNP
rs1458453674 1454 dbSNP
rs142608123 1460 dbSNP
rs892880706 1460 dbSNP
rs551777302 1461 dbSNP
rs1261169861 1464 dbSNP
rs916331050 1471 dbSNP
rs201435073 1480 dbSNP
rs199781314 1482 dbSNP
rs1162058920 1484 dbSNP
rs200516855 1487 dbSNP
rs1043507696 1488 dbSNP
rs143577934 1491 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1
miRNA  3' acgacaauCGGGAUCGGGGCGu 5'
                  |||| |||||:|| 
Target 5' -----cctGCCC-AGCCCTGCc 3'
1 - 16
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.761 4.9e-5 -0.838 2.0e-6 20 Click to see details
GSE28544 Breast cancer -0.53 3.9e-3 -0.512 5.3e-3 24 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.48 7.6e-3 0.337 5.0e-2 25 Click to see details
GSE38226 Liver fibrosis 0.355 5.7e-2 0.352 5.9e-2 21 Click to see details
GSE42095 Differentiated embryonic stem cells 0.294 8.7e-2 0.361 4.5e-2 23 Click to see details
GSE21687 Ependynoma primary tumors -0.167 9.4e-2 -0.074 2.8e-1 64 Click to see details
GSE21032 Prostate cancer -0.136 1.1e-1 -0.100 1.8e-1 83 Click to see details
GSE19350 CNS germ cell tumors -0.382 1.1e-1 -0.329 1.5e-1 12 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.412 1.4e-1 0.267 2.4e-1 9 Click to see details
GSE19783 ER+ ER+ breast cancer 0.242 1.5e-1 0.262 1.3e-1 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.198 1.7e-1 -0.310 6.6e-2 25 Click to see details
GSE19536 Breast cancer 0.092 1.8e-1 0.022 4.1e-1 100 Click to see details
GSE17498 Multiple myeloma 0.147 1.8e-1 0.227 7.9e-2 40 Click to see details
GSE26953 Aortic valvular endothelial cells -0.188 1.9e-1 -0.159 2.3e-1 24 Click to see details
GSE32688 Pancreatic cancer -0.059 3.7e-1 -0.008 4.8e-1 32 Click to see details
GSE28260 Renal cortex and medulla -0.077 4.0e-1 0.011 4.9e-1 13 Click to see details
GSE19783 ER- ER- breast cancer 0.003 4.9e-1 -0.055 3.2e-1 79 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.149 0.09 0.129 0.12 84 Click to see details
BLCA -0.25 0.16 -0.084 0.37 18 Click to see details
KICH -0.176 0.2 -0.097 0.32 25 Click to see details
HNSC -0.129 0.21 -0.188 0.12 42 Click to see details
CHOL -0.306 0.21 -0.033 0.47 9 Click to see details
LIHC 0.116 0.21 0.014 0.46 49 Click to see details
ESCA 0.237 0.24 0.373 0.13 11 Click to see details
LUAD -0.193 0.27 -0.091 0.39 12 Click to see details
UCEC -0.147 0.27 -0.240 0.16 19 Click to see details
THCA 0.06 0.33 0.061 0.32 59 Click to see details
KIRP -0.079 0.33 -0.043 0.41 32 Click to see details
LUSC -0.065 0.35 -0.063 0.35 38 Click to see details
KIRC 0.035 0.39 0.005 0.48 68 Click to see details
STAD 0.036 0.42 -0.014 0.47 32 Click to see details
PAAD 0.123 0.44 0.200 0.4 4 Click to see details
COAD 0.063 0.44 0.000 0.5 8 Click to see details
PRAD 0.01 0.47 0.135 0.17 50 Click to see details
PCPG -0.058 0.48 0.500 0.33 3 Click to see details
CESC 0.011 0.5 0.500 0.33 3 Click to see details
CESC 0.011 0.5 0.500 0.33 3 Click to see details
CESC 0.011 0.5 0.500 0.33 3 Click to see details
412 hsa-miR-744-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT016085 ARL15 ADP ribosylation factor like GTPase 15 1 1
MIRT016086 AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 1 2
MIRT016087 PPTC7 PTC7 protein phosphatase homolog 2 3
MIRT016088 RASSF1 Ras association domain family member 1 1 1
MIRT016089 IER5 immediate early response 5 1 1
MIRT037383 UFC1 ubiquitin-fold modifier conjugating enzyme 1 1 1
MIRT037384 STAM2 signal transducing adaptor molecule 2 1 1
MIRT037385 SRRM2 serine/arginine repetitive matrix 2 1 1
MIRT037386 DCXR dicarbonyl and L-xylulose reductase 1 1
MIRT037387 TSPAN17 tetraspanin 17 1 1
MIRT037388 ACTB actin beta 1 1
MIRT037389 HIST1H2BC histone cluster 1 H2B family member c 1 1
MIRT037390 ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 1 1
MIRT037391 VDAC1 voltage dependent anion channel 1 1 1
MIRT037392 RNASEK ribonuclease K 1 1
MIRT037393 CDK16 cyclin dependent kinase 16 1 1
MIRT037394 ZCCHC24 zinc finger CCHC-type containing 24 1 1
MIRT037395 ARRDC2 arrestin domain containing 2 1 1
MIRT037396 SGMS1 sphingomyelin synthase 1 1 1
MIRT037397 HSPD1 heat shock protein family D (Hsp60) member 1 1 1
MIRT037398 MRPL46 mitochondrial ribosomal protein L46 1 1
MIRT037399 RHEB Ras homolog, mTORC1 binding 1 1
MIRT037400 ND1 NADH dehydrogenase, subunit 1 (complex I) 1 1
MIRT037401 TP53I13 tumor protein p53 inducible protein 13 1 1
MIRT037402 CD44 CD44 molecule (Indian blood group) 1 1
MIRT037403 USP12 ubiquitin specific peptidase 12 1 1
MIRT037404 AP2B1 adaptor related protein complex 2 beta 1 subunit 1 1
MIRT037405 RPL18A ribosomal protein L18a 1 1
MIRT037406 PPP1CA protein phosphatase 1 catalytic subunit alpha 1 1
MIRT037407 TNRC6B trinucleotide repeat containing 6B 1 1
MIRT037408 PXK PX domain containing serine/threonine kinase like 1 1
MIRT037409 TDRKH tudor and KH domain containing 1 1
MIRT037410 PRRC2A proline rich coiled-coil 2A 1 1
MIRT037411 ATP11A ATPase phospholipid transporting 11A 1 1
MIRT037412 NDE1 nudE neurodevelopment protein 1 1 1
MIRT037413 STK16 serine/threonine kinase 16 1 1
MIRT037414 PSMB2 proteasome subunit beta 2 1 1
MIRT037415 EPN1 epsin 1 1 1
MIRT037416 EN2 engrailed homeobox 2 1 1
MIRT037417 LARP1 La ribonucleoprotein domain family member 1 1 1
MIRT037418 SRCAP Snf2 related CREBBP activator protein 1 1
MIRT037419 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 1 1
MIRT037420 AP2A2 adaptor related protein complex 2 alpha 2 subunit 1 1
MIRT037421 ACTG1 actin gamma 1 1 1
MIRT037422 PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing 1 1
MIRT037423 UBE2O ubiquitin conjugating enzyme E2 O 1 1
MIRT037424 KLHL15 kelch like family member 15 1 1
MIRT037425 SECISBP2 SECIS binding protein 2 1 1
MIRT037426 KIAA0922 transmembrane 131 like 1 1
MIRT037427 PTMA prothymosin, alpha 1 1
MIRT037428 WDR45B WD repeat domain 45B 1 1
MIRT037429 ZNF282 zinc finger protein 282 1 1
MIRT037430 GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 1 1
MIRT037431 TNKS tankyrase 1 1
MIRT037432 NOP2 NOP2 nucleolar protein 1 1
MIRT037433 GAK cyclin G associated kinase 1 1
MIRT037434 ATP6 ATP synthase F0 subunit 6 1 1
MIRT037435 DIDO1 death inducer-obliterator 1 1 1
MIRT037436 RPL3 ribosomal protein L3 1 1
MIRT037437 AIMP2 aminoacyl tRNA synthetase complex interacting multifunctional protein 2 1 1
MIRT037438 PIGC phosphatidylinositol glycan anchor biosynthesis class C 1 1
MIRT037439 ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 1 1
MIRT037440 USP21 ubiquitin specific peptidase 21 1 1
MIRT037441 NUFIP2 NUFIP2, FMR1 interacting protein 2 1 1
MIRT037442 RPS6 ribosomal protein S6 1 1
MIRT037443 ILKAP ILK associated serine/threonine phosphatase 1 1
MIRT037444 COX1 cytochrome c oxidase subunit I 1 1
MIRT037445 VPS37C VPS37C, ESCRT-I subunit 1 1
MIRT037446 CDK12 cyclin dependent kinase 12 1 1
MIRT037447 RBM8A RNA binding motif protein 8A 1 1
MIRT037448 CKB creatine kinase B 1 1
MIRT037449 DHX57 DExH-box helicase 57 1 1
MIRT037450 DDX23 DEAD-box helicase 23 1 1
MIRT037451 ABI3 ABI family member 3 1 1
MIRT037452 GATAD2B GATA zinc finger domain containing 2B 1 1
MIRT037453 PDPK1 3-phosphoinositide dependent protein kinase 1 1 1
MIRT037454 C17orf70 Fanconi anemia core complex associated protein 100 1 1
MIRT037455 SKI SKI proto-oncogene 1 1
MIRT037456 KCTD11 potassium channel tetramerization domain containing 11 1 1
MIRT037457 GNB2L1 receptor for activated C kinase 1 1 1
MIRT037458 NCOA3 nuclear receptor coactivator 3 1 1
MIRT037459 PAK4 p21 (RAC1) activated kinase 4 2 3
MIRT037460 GDI2 GDP dissociation inhibitor 2 1 1
MIRT037461 SLC2A4RG SLC2A4 regulator 1 1
MIRT037462 SLX4 SLX4 structure-specific endonuclease subunit 1 1
MIRT037463 COPA coatomer protein complex subunit alpha 1 1
MIRT037464 GPRASP2 G protein-coupled receptor associated sorting protein 2 1 1
MIRT037465 GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 1 1
MIRT037466 LIMS1 LIM zinc finger domain containing 1 1 1
MIRT037467 COTL1 coactosin like F-actin binding protein 1 1 1
MIRT037468 CAPNS1 calpain small subunit 1 1 1
MIRT037469 FRZB frizzled-related protein 1 1
MIRT037470 UBQLN4 ubiquilin 4 1 1
MIRT037471 NUP153 nucleoporin 153 1 1
MIRT037472 TMEM175 transmembrane protein 175 1 1
MIRT037473 HIST1H2BD histone cluster 1 H2B family member d 1 1
MIRT037474 SREBF1 sterol regulatory element binding transcription factor 1 1 1
MIRT037475 BCL2L12 BCL2 like 12 1 1
MIRT037476 HIST2H2AA3 histone cluster 2 H2A family member a3 1 1
MIRT037477 MINK1 misshapen like kinase 1 1 1
MIRT037478 PDXK pyridoxal kinase 1 1
MIRT037479 FAM110A family with sequence similarity 110 member A 1 1
MIRT037480 ZNF598 zinc finger protein 598 1 1
MIRT037481 ILK integrin linked kinase 1 1
MIRT037482 HINT1 histidine triad nucleotide binding protein 1 1 1
MIRT037483 WBP2 WW domain binding protein 2 1 1
MIRT037484 CYTB cytochrome b 1 1
MIRT037485 SCAMP2 secretory carrier membrane protein 2 1 1
MIRT037486 TRIM33 tripartite motif containing 33 1 1
MIRT037487 SLC25A3 solute carrier family 25 member 3 1 1
MIRT037488 IRS4 insulin receptor substrate 4 1 1
MIRT037489 TSR1 TSR1, ribosome maturation factor 1 1
MIRT037490 TCOF1 treacle ribosome biogenesis factor 1 1 1
MIRT037491 ATXN2L ataxin 2 like 1 1
MIRT037492 MTOR mechanistic target of rapamycin kinase 1 1
MIRT037493 ZNF318 zinc finger protein 318 1 1
MIRT037494 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 3
MIRT037495 SAMD4B sterile alpha motif domain containing 4B 1 1
MIRT037496 STMN1 stathmin 1 1 1
MIRT037497 SAT1 spermidine/spermine N1-acetyltransferase 1 1 1
MIRT037498 SALL1 spalt like transcription factor 1 1 1
MIRT037499 ZSCAN18 zinc finger and SCAN domain containing 18 1 1
MIRT037500 SLC35D1 solute carrier family 35 member D1 1 1
MIRT037501 TM9SF3 transmembrane 9 superfamily member 3 1 1
MIRT037502 TIAM1 T-cell lymphoma invasion and metastasis 1 1 1
MIRT037503 CHD5 chromodomain helicase DNA binding protein 5 1 1
MIRT037504 BAG6 BCL2 associated athanogene 6 1 1
MIRT037505 MED28 mediator complex subunit 28 1 1
MIRT037506 ANKRD52 ankyrin repeat domain 52 1 1
MIRT037507 MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 1 1
MIRT037508 PPDPF pancreatic progenitor cell differentiation and proliferation factor 1 1
MIRT037509 PRKACA protein kinase cAMP-activated catalytic subunit alpha 1 1
MIRT037510 HPCAL4 hippocalcin like 4 1 1
MIRT037511 ZNF256 zinc finger protein 256 1 1
MIRT037512 CGNL1 cingulin like 1 1 1
MIRT037513 TUBA1B tubulin alpha 1b 1 1
MIRT037514 LNPEP leucyl and cystinyl aminopeptidase 1 1
MIRT037515 PDE4A phosphodiesterase 4A 1 1
MIRT037516 HOXD11 homeobox D11 2 3
MIRT037517 QARS glutaminyl-tRNA synthetase 1 1
MIRT037518 G3BP1 G3BP stress granule assembly factor 1 1 1
MIRT037519 PLEKHM2 pleckstrin homology and RUN domain containing M2 1 1
MIRT037520 POLR2A RNA polymerase II subunit A 1 1
MIRT037521 KIAA1462 junctional cadherin 5 associated 1 1
MIRT037522 SF3A1 splicing factor 3a subunit 1 1 1
MIRT037523 YBX1 Y-box binding protein 1 1 1
MIRT037524 PTGES3 prostaglandin E synthase 3 1 1
MIRT037525 FOXO3 forkhead box O3 1 1
MIRT037526 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 1 1
MIRT037527 AARS alanyl-tRNA synthetase 1 1
MIRT037528 ZNF155 zinc finger protein 155 1 1
MIRT037529 NCS1 neuronal calcium sensor 1 1 1
MIRT037530 FKBP4 FK506 binding protein 4 1 1
MIRT037531 ARHGDIA Rho GDP dissociation inhibitor alpha 1 1
MIRT037532 MAPK7 mitogen-activated protein kinase 7 1 1
MIRT037533 AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 1 1
MIRT037534 HIST1H1E histone cluster 1 H1 family member e 1 1
MIRT037535 MLF2 myeloid leukemia factor 2 1 1
MIRT037536 EDC3 enhancer of mRNA decapping 3 1 1
MIRT037537 CHRAC1 chromatin accessibility complex 1 1 1
MIRT037538 WIPF3 WAS/WASL interacting protein family member 3 1 1
MIRT037539 COX2 cytochrome c oxidase subunit II 1 1
MIRT037540 SRSF1 serine and arginine rich splicing factor 1 1 1
MIRT037541 CTNNBIP1 catenin beta interacting protein 1 1 1
MIRT037542 RPL4 ribosomal protein L4 1 1
MIRT037543 COX3 cytochrome c oxidase III 1 1
MIRT037544 DDX54 DEAD-box helicase 54 1 1
MIRT037545 TOB2 transducer of ERBB2, 2 1 1
MIRT037546 MAN2C1 mannosidase alpha class 2C member 1 1 1
MIRT037547 SMCR7L mitochondrial elongation factor 1 1 1
MIRT037548 RPLP1 ribosomal protein lateral stalk subunit P1 1 1
MIRT037549 RAN RAN, member RAS oncogene family 1 1
MIRT037550 NONO non-POU domain containing octamer binding 1 1
MIRT037551 CYB5R3 cytochrome b5 reductase 3 1 1
MIRT037552 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 1 1
MIRT037553 COLGALT1 collagen beta(1-O)galactosyltransferase 1 1 1
MIRT037554 MGRN1 mahogunin ring finger 1 1 1
MIRT037555 ANAPC1 anaphase promoting complex subunit 1 1 1
MIRT037556 TBX1 T-box 1 1 1
MIRT037557 NXPH4 neurexophilin 4 1 1
MIRT037558 HSPA1B heat shock protein family A (Hsp70) member 1B 1 1
MIRT037559 UBE2A ubiquitin conjugating enzyme E2 A 1 1
MIRT037560 KPNB1 karyopherin subunit beta 1 1 1
MIRT037561 NDUFB10 NADH:ubiquinone oxidoreductase subunit B10 1 1
MIRT037562 SYMPK symplekin 1 1
MIRT037563 SYPL1 synaptophysin like 1 1 1
MIRT037564 LRP3 LDL receptor related protein 3 1 1
MIRT037565 DDX24 DEAD-box helicase 24 1 1
MIRT037566 WDR37 WD repeat domain 37 1 1
MIRT037567 RPS14 ribosomal protein S14 1 1
MIRT037568 FAM53C family with sequence similarity 53 member C 1 1
MIRT037569 NMT1 N-myristoyltransferase 1 1 1
MIRT037570 PAGR1 PAXIP1 associated glutamate rich protein 1 1 1
MIRT037571 AKT2 AKT serine/threonine kinase 2 1 1
MIRT037572 TMEM14C transmembrane protein 14C 1 1
MIRT037573 MEX3D mex-3 RNA binding family member D 1 1
MIRT037574 BRAF B-Raf proto-oncogene, serine/threonine kinase 1 1
MIRT037575 POLR2L RNA polymerase II subunit L 1 1
MIRT037576 SERP1 stress associated endoplasmic reticulum protein 1 1 1
MIRT037577 C8orf33 chromosome 8 open reading frame 33 1 1
MIRT037578 NR1D2 nuclear receptor subfamily 1 group D member 2 1 1
MIRT037579 POLD3 DNA polymerase delta 3, accessory subunit 1 1
MIRT037580 HMGA1 high mobility group AT-hook 1 1 1
MIRT037581 SLC35B4 solute carrier family 35 member B4 1 1
MIRT037582 PELP1 proline, glutamate and leucine rich protein 1 1 1
MIRT037583 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 1 1
MIRT037584 RPL7A ribosomal protein L7a 1 1
MIRT037585 LAIR1 leukocyte associated immunoglobulin like receptor 1 1 1
MIRT037586 RPL10 ribosomal protein L10 1 1
MIRT037587 MRPS16 mitochondrial ribosomal protein S16 1 1
MIRT037588 SRM spermidine synthase 1 1
MIRT037589 EIF3K eukaryotic translation initiation factor 3 subunit K 1 1
MIRT037590 DESI1 desumoylating isopeptidase 1 1 1
MIRT037591 BET1 Bet1 golgi vesicular membrane trafficking protein 1 1
MIRT037592 HTRA2 HtrA serine peptidase 2 1 1
MIRT037593 LARP6 La ribonucleoprotein domain family member 6 1 1
MIRT037594 NOTCH2 notch 2 1 1
MIRT037595 ADCY9 adenylate cyclase 9 1 1
MIRT037596 C6orf62 chromosome 6 open reading frame 62 1 1
MIRT037597 FBXL19 F-box and leucine rich repeat protein 19 1 1
MIRT037598 L3MBTL2 L3MBTL2, polycomb repressive complex 1 subunit 1 1
MIRT037599 TRIM28 tripartite motif containing 28 1 1
MIRT037600 LGALS3 galectin 3 1 1
MIRT037601 IGSF8 immunoglobulin superfamily member 8 1 1
MIRT037602 LIN37 lin-37 DREAM MuvB core complex component 1 1
MIRT037603 PTPRF protein tyrosine phosphatase, receptor type F 1 1
MIRT037604 MTSS1L MTSS1L, I-BAR domain containing 1 1
MIRT037605 TRMT2A tRNA methyltransferase 2 homolog A 1 1
MIRT037606 DVL1 dishevelled segment polarity protein 1 1 1
MIRT037607 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 1 1
MIRT037608 TOR2A torsin family 2 member A 1 1
MIRT037609 RPS6KA5 ribosomal protein S6 kinase A5 1 1
MIRT037610 SMYD4 SET and MYND domain containing 4 1 1
MIRT037611 TJAP1 tight junction associated protein 1 1 1
MIRT037612 IRAK1 interleukin 1 receptor associated kinase 1 1 1
MIRT037613 PPM1M protein phosphatase, Mg2+/Mn2+ dependent 1M 1 1
MIRT037614 EIF4A2 eukaryotic translation initiation factor 4A2 1 1
MIRT037615 GFER growth factor, augmenter of liver regeneration 1 1
MIRT037616 PKP2 plakophilin 2 1 1
MIRT037617 FARSB phenylalanyl-tRNA synthetase beta subunit 1 1
MIRT037618 OPRD1 opioid receptor delta 1 1 1
MIRT037619 CCNY cyclin Y 1 1
MIRT037620 CNOT1 CCR4-NOT transcription complex subunit 1 1 1
MIRT037621 CXCL16 C-X-C motif chemokine ligand 16 1 1
MIRT037622 CEBPA CCAAT/enhancer binding protein alpha 1 1
MIRT037623 DDX11 DEAD/H-box helicase 11 1 1
MIRT037624 URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 1 1
MIRT037625 SBF1 SET binding factor 1 1 1
MIRT037626 GNB2 G protein subunit beta 2 1 1
MIRT037627 KMT2D lysine methyltransferase 2D 2 3
MIRT037628 DDX17 DEAD-box helicase 17 1 1
MIRT037629 SORBS3 sorbin and SH3 domain containing 3 1 1
MIRT037630 TAPBP TAP binding protein 1 1
MIRT037631 BCR BCR, RhoGEF and GTPase activating protein 1 1
MIRT037632 RPL18 ribosomal protein L18 1 1
MIRT037633 INTS3 integrator complex subunit 3 1 1
MIRT037634 CDC25B cell division cycle 25B 1 1
MIRT037635 LDOC1L retrotransposon Gag like 6 1 1
MIRT037636 TUB tubby bipartite transcription factor 1 1
MIRT037637 NUDT2 nudix hydrolase 2 1 1
MIRT037638 CDAN1 codanin 1 1 1
MIRT037639 MRS2 MRS2, magnesium transporter 1 1
MIRT037640 PYGB glycogen phosphorylase B 1 1
MIRT037641 LDLRAD3 low density lipoprotein receptor class A domain containing 3 1 1
MIRT037642 COL5A1 collagen type V alpha 1 chain 1 1
MIRT037643 ATF7IP activating transcription factor 7 interacting protein 1 1
MIRT037644 AGO1 argonaute 1, RISC catalytic component 1 1
MIRT037645 ZNF212 zinc finger protein 212 1 1
MIRT037646 TSC2 TSC complex subunit 2 1 1
MIRT037647 FASN fatty acid synthase 1 1
MIRT037648 NOL9 nucleolar protein 9 1 1
MIRT037649 CLUH clustered mitochondria homolog 1 1
MIRT037650 PHF8 PHD finger protein 8 1 1
MIRT037651 EIF4G1 eukaryotic translation initiation factor 4 gamma 1 1 1
MIRT037652 TRAPPC12 trafficking protein particle complex 12 1 1
MIRT037653 HOXC11 homeobox C11 1 1
MIRT037654 DGCR14 ess-2 splicing factor homolog 1 1
MIRT037655 SLC25A1 solute carrier family 25 member 1 1 1
MIRT037656 MEX3C mex-3 RNA binding family member C 1 1
MIRT037657 RAI1 retinoic acid induced 1 1 1
MIRT037658 LY6E lymphocyte antigen 6 family member E 1 1
MIRT037659 SEC16A SEC16 homolog A, endoplasmic reticulum export factor 1 1
MIRT037660 RPL37 ribosomal protein L37 1 1
MIRT037661 CNN2 calponin 2 1 1
MIRT037662 ALDH18A1 aldehyde dehydrogenase 18 family member A1 1 1
MIRT037663 POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 1 1
MIRT037664 EIF4A1 eukaryotic translation initiation factor 4A1 1 1
MIRT037665 PIM3 Pim-3 proto-oncogene, serine/threonine kinase 1 1
MIRT037666 PTPMT1 protein tyrosine phosphatase, mitochondrial 1 1 1
MIRT037667 NCEH1 neutral cholesterol ester hydrolase 1 1 1
MIRT037668 ART5 ADP-ribosyltransferase 5 1 1
MIRT037669 MRPS2 mitochondrial ribosomal protein S2 1 1
MIRT037670 NCL nucleolin 1 1
MIRT037671 NCKAP5L NCK associated protein 5 like 1 1
MIRT037672 ZCCHC14 zinc finger CCHC-type containing 14 1 1
MIRT037673 CCDC71 coiled-coil domain containing 71 1 1
MIRT037674 SURF4 surfeit 4 1 1
MIRT037675 RPL13 ribosomal protein L13 1 1
MIRT037676 ACTN4 actinin alpha 4 1 1
MIRT037677 PA2G4 proliferation-associated 2G4 1 1
MIRT037678 MIF macrophage migration inhibitory factor 1 1
MIRT037679 UBE2N ubiquitin conjugating enzyme E2 N 1 1
MIRT037680 LYNX1 Ly6/neurotoxin 1 1 1
MIRT037681 TACC3 transforming acidic coiled-coil containing protein 3 1 1
MIRT037682 GSR glutathione-disulfide reductase 1 1
MIRT037683 GSK3A glycogen synthase kinase 3 alpha 1 1
MIRT037684 ZMYM3 zinc finger MYM-type containing 3 1 1
MIRT037685 ERP29 endoplasmic reticulum protein 29 1 1
MIRT037686 MATR3 matrin 3 1 1
MIRT037687 FANCG Fanconi anemia complementation group G 1 1
MIRT037688 FAM83G family with sequence similarity 83 member G 1 1
MIRT037689 DUSP18 dual specificity phosphatase 18 1 1
MIRT037690 MYC MYC proto-oncogene, bHLH transcription factor 3 2
MIRT037691 TSPAN7 tetraspanin 7 1 1
MIRT037692 ATMIN ATM interactor 1 1
MIRT037693 SEPT2 septin 2 1 1
MIRT037694 FOXRED2 FAD dependent oxidoreductase domain containing 2 1 1
MIRT037695 TECR trans-2,3-enoyl-CoA reductase 1 1
MIRT037696 MRPL11 mitochondrial ribosomal protein L11 1 1
MIRT037697 IP6K1 inositol hexakisphosphate kinase 1 1 1
MIRT037698 PSMD4 proteasome 26S subunit, non-ATPase 4 1 1
MIRT037699 SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 1 1
MIRT037700 CTNNB1 catenin beta 1 1 1
MIRT037701 TMEM189 transmembrane protein 189 1 1
MIRT037702 LDLR low density lipoprotein receptor 1 1
MIRT037703 OGFR opioid growth factor receptor 1 1
MIRT037704 ADAP2 ArfGAP with dual PH domains 2 1 1
MIRT037705 LIPA lipase A, lysosomal acid type 1 1
MIRT037706 SNAPC4 small nuclear RNA activating complex polypeptide 4 1 1
MIRT037707 FBN2 fibrillin 2 1 1
MIRT037708 ZNF704 zinc finger protein 704 1 1
MIRT037709 EIF3M eukaryotic translation initiation factor 3 subunit M 1 1
MIRT037710 SMC1A structural maintenance of chromosomes 1A 1 1
MIRT037711 FZR1 fizzy and cell division cycle 20 related 1 1 1
MIRT037712 NANOS1 nanos C2HC-type zinc finger 1 1 1
MIRT037713 PRR12 proline rich 12 1 1
MIRT037714 PHC2 polyhomeotic homolog 2 1 1
MIRT037715 NOP9 NOP9 nucleolar protein 1 1
MIRT037716 HM13 histocompatibility minor 13 1 1
MIRT037717 PRDX5 peroxiredoxin 5 1 1
MIRT037718 IRGQ immunity related GTPase Q 1 1
MIRT037719 TGFB1 transforming growth factor beta 1 7 2
MIRT037720 MARCH3 membrane associated ring-CH-type finger 3 1 1
MIRT037721 TBX2 T-box 2 1 1
MIRT037722 TSC22D3 TSC22 domain family member 3 1 1
MIRT037723 DUT deoxyuridine triphosphatase 1 1
MIRT037724 FAM171A2 family with sequence similarity 171 member A2 1 1
MIRT037725 FGFR1 fibroblast growth factor receptor 1 1 1
MIRT037726 FRAT1 FRAT1, WNT signaling pathway regulator 1 1
MIRT037727 PSMD11 proteasome 26S subunit, non-ATPase 11 1 1
MIRT037728 PABPC1 poly(A) binding protein cytoplasmic 1 1 1
MIRT037729 ENO1 enolase 1 1 1
MIRT037730 AP3D1 adaptor related protein complex 3 delta 1 subunit 1 1
MIRT037731 TUBA1A tubulin alpha 1a 1 1
MIRT037732 ULK3 unc-51 like kinase 3 1 1
MIRT037733 PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha 1 1
MIRT037734 SLC25A46 solute carrier family 25 member 46 1 1
MIRT037735 MED15 mediator complex subunit 15 1 1
MIRT037736 IRF2BP1 interferon regulatory factor 2 binding protein 1 1 1
MIRT037737 UBA1 ubiquitin like modifier activating enzyme 1 1 1
MIRT037738 ATHL1 protein-glucosylgalactosylhydroxylysine glucosidase 1 1
MIRT037739 CTNNA1 catenin alpha 1 1 1
MIRT037740 ADRM1 adhesion regulating molecule 1 1 1
MIRT037741 CCDC106 coiled-coil domain containing 106 1 1
MIRT054493 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 3 1
MIRT451195 PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 2 2
MIRT452931 DISC1 disrupted in schizophrenia 1 2 2
MIRT455468 LYPLA2 lysophospholipase II 2 2
MIRT457068 TOR4A torsin family 4 member A 2 2
MIRT464195 VGLL4 vestigial like family member 4 2 4
MIRT483030 KHSRP KH-type splicing regulatory protein 2 4
MIRT486062 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT486120 INO80E INO80 complex subunit E 2 2
MIRT486866 DPF1 double PHD fingers 1 2 2
MIRT488343 PAX2 paired box 2 2 2
MIRT488790 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT490249 MFI2 melanotransferrin 2 2
MIRT490264 HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2 2
MIRT490756 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT492321 SETD1B SET domain containing 1B 2 2
MIRT492851 NRGN neurogranin 2 2
MIRT499604 ANKRD45 ankyrin repeat domain 45 2 2
MIRT500189 BARX1 BARX homeobox 1 2 4
MIRT516765 FAM212B family with sequence similarity 212 member B 2 4
MIRT517949 TRIM59 tripartite motif containing 59 2 2
MIRT521182 SCAF4 SR-related CTD associated factor 4 2 2
MIRT526462 OSBPL5 oxysterol binding protein like 5 2 2
MIRT535148 PLEKHG5 pleckstrin homology and RhoGEF domain containing G5 2 2
MIRT569528 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 2
MIRT570593 NFIX nuclear factor I X 2 2
MIRT571219 F2R coagulation factor II thrombin receptor 2 2
MIRT574145 MARVELD1 MARVEL domain containing 1 2 2
MIRT608758 CACNA1A calcium voltage-gated channel subunit alpha1 A 2 2
MIRT649509 RAB17 RAB17, member RAS oncogene family 2 2
MIRT692165 RNF207 ring finger protein 207 2 2
MIRT703495 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT711081 NEUROD2 neuronal differentiation 2 2 2
MIRT712090 UNC13A unc-13 homolog A 2 2
MIRT712531 CYTH2 cytohesin 2 2 2
MIRT712755 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT712893 TGFA transforming growth factor alpha 2 2
MIRT714684 PRX periaxin 2 2
MIRT714723 VPS8 VPS8, CORVET complex subunit 2 2
MIRT714814 NOB1 NIN1/PSMD8 binding protein 1 homolog 2 2
MIRT716774 C1orf229 chromosome 1 open reading frame 229 2 2
MIRT717511 HRNR hornerin 2 2
MIRT717653 THBS2 thrombospondin 2 2 2
MIRT719595 PIAS4 protein inhibitor of activated STAT 4 2 2
MIRT720525 PTGR2 prostaglandin reductase 2 2 2
MIRT724925 VPS18 VPS18, CORVET/HOPS core subunit 2 2
MIRT737146 NOS3 nitric oxide synthase 3 1 0
MIRT756003 SLC7A5 solute carrier family 7 member 5 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-744 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-744 Tert-butyl hydroperoxide (t-BHP) NULL 6410 Microarray mouse auditory cells 20510889 2010 up-regulated
miR-744 Ursodeoxycholic acid (UDCA) approved 31401 Microarray rat Liver 20689055 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-744 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901)
hsa-mir-744 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-744 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-744 Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-mir-744 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-744 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-744 Cisplatin 5460033 NSC119875 approved resistant cell line (SGC-7901)
hsa-miR-744-5p [1,1'-binaphthalene]-2,2',3,3'-tetrol 316673 NSC245006 sensitive
hsa-miR-744-5p 4-n-[12-[(5-amino-6-chloropyrimidin-4-yl)amino]dodecyl]-6-chloropyrimidine-4,5-diamine 358989 NSC619196 sensitive
hsa-miR-744-5p 5,7-dibromo-2-[(e)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]quinolin-8-ol 135460261 NSC67090 sensitive
hsa-miR-744-5p Benzyl 2-(dibenzylamino)-3-phenylpropanoate 375616 NSC655438 sensitive
hsa-miR-744-5p N'-[(Z)-[(4Z)-2-(1,3-benzodioxol-5-yl)-4-[[4-oxo-4-[2-(trifluoromethyl)anilino]butanoyl]hydrazinylidene]chromen-3-ylidene]amino]-N-[2-(trifluoromethyl)phenyl]butanediamide 6399328 NSC641210 sensitive
hsa-miR-744-5p Paullone analog 47 396411 NSC702373 sensitive
hsa-miR-744-5p Ursa-11,13(18)-dien-28-oic acid-3.beta.-ol 378695 NSC661747 sensitive
hsa-miR-744-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7, LY2)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3)
hsa-miR-744-5p Carboplatin 38904 NSC241240 approved sensitive High Ovarian Cancer tissue and cell line (MDAH-2274, SKOV3)
hsa-miR-744-5p Gefitinib 123631 NSC715055 approved resistant High Lung Adenocarcinoma cell line (A549)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved sensitive High Esophageal Squamous Cell Carcinoma cell line (KYSE410)
hsa-miR-744-5p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-744-5p Vinorelbine 44424639 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-744-5p Epirubicin 41867 NSC256942 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-744-5p Erlotinib 176870 NSC718781 approved sensitive High Non-Small Cell Lung Cancer tissue
hsa-miR-744-5p Gefitinib 123631 NSC715055 approved sensitive High Non-Small Cell Lung Cancer tissue
hsa-miR-744-5p Sunitinib 5329102 NSC750690 approved sensitive High Renal Cell Cancer tissue
hsa-miR-744-5p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-744-5p Sorafenib 216239 NSC747971 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901, BGC-823)
hsa-miR-744-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Colorectal Cancer cell line (HCT-116)
hsa-miR-744-5p Bortezomib 387447 NSC681239 approved sensitive Low Multiple Myeloma tissue
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-744-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-744-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-744-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-744-5p Fluorouracil 3385 NSC19893 approved sensitive cell line (HCT15)
hsa-miR-744-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-744-5p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-744-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-744-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-744-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-744-5p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-744-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-744-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-744-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-744-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (H23)

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