pre-miRNA Information
pre-miRNA hsa-mir-744   
Genomic Coordinates chr17: 12081899 - 12081996
Synonyms MIRN744, hsa-mir-744, MIR744
Description Homo sapiens miR-744 stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-744-5p
Sequence 11| UGCGGGGCUAGGGCUAACAGCA |32
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN23015028 1 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs557969425 1 dbSNP
rs748252260 4 dbSNP
rs1470408501 7 dbSNP
rs1178657616 10 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B6B8SM miR-744-5p Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Urine Real-time polymerase chain reaction
Gene Information
Gene Symbol TSC2   
Synonyms LAM, PPP1R160, TSC4
Description TSC complex subunit 2
Transcript NM_000548   
Other Transcripts NM_001077183 , NM_001114382   
Expression
Putative miRNA Targets on TSC2
3'UTR of TSC2
(miRNA target sites are highlighted)
>TSC2|NM_000548|3'UTR
   1 GGCCGGGGCCCTCCCTCCTGCACTGGCCTTGGACGGTATTGCCTGTCAGTGAAATAAATAAAGTCCTGACCCCAGTGCAC
  81 AGACATAGAGGCACAGATTGCAGTCAGACAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' acGACAAUCGGGAUCGGGGCgu 5'
            ||  | || ||:|||::|  
Target 5' ccCTCCT-GCACTGGCCTTGga 3'
13 - 33 107.00 -14.10
2
miRNA  3' acgacaaUCGGGAUCGGGGcgu 5'
                 ||:|||: ||||   
Target 5' taaataaAGTCCTGACCCCagt 3'
55 - 76 95.00 -18.20
3
miRNA  3' acgacaaUCGGGAU---CGGGGCgu 5'
                 || | ||   || | |  
Target 5' agtgcacAGACATAGAGGCACAGat 3'
74 - 98 63.00 -6.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
486611 5 ClinVar
184450 6 ClinVar
65017 7 ClinVar
379639 8 ClinVar
1204303 13 ClinVar
318339 24 ClinVar
49662 27 ClinVar
256617 36 ClinVar
318340 45 ClinVar
49664 52 ClinVar
50172 60 ClinVar
65166 62 ClinVar
318341 72 ClinVar
50173 72 ClinVar
318342 78 ClinVar
885118 87 ClinVar
65144 128 ClinVar
65276 128 ClinVar
65208 129 ClinVar
65179 141 ClinVar
64862 148 ClinVar
1178576 256 ClinVar
1180280 263 ClinVar
1194539 270 ClinVar
1049696 272 ClinVar
COSN19618148 3 COSMIC
COSN30570356 60 COSMIC
COSN19658106 73 COSMIC
COSN31597361 125 COSMIC
COSN30554789 155 COSMIC
COSN20112544 273 COSMIC
COSN23987363 274 COSMIC
COSN22236664 283 COSMIC
COSN26257692 401 COSMIC
COSN6644781 517 COSMIC
COSN27564835 709 COSMIC
COSN30543727 814 COSMIC
COSN26769728 816 COSMIC
COSN7300909 821 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs139486245 2 dbSNP
rs760530789 3 dbSNP
rs766295684 4 dbSNP
rs368282661 5 dbSNP
rs201342697 6 dbSNP
rs397515008 7 dbSNP
rs757824592 8 dbSNP
rs765016970 8 dbSNP
rs574951361 9 dbSNP
rs928957040 10 dbSNP
rs369444910 11 dbSNP
rs757991038 12 dbSNP
rs544055911 13 dbSNP
rs746489853 14 dbSNP
rs530469388 15 dbSNP
rs1484665370 16 dbSNP
rs1212082573 19 dbSNP
rs1365017011 20 dbSNP
rs373380255 21 dbSNP
rs769209921 22 dbSNP
rs774841226 24 dbSNP
rs1403383726 25 dbSNP
rs748394239 26 dbSNP
rs13332015 27 dbSNP
rs1328003906 28 dbSNP
rs370169726 28 dbSNP
rs760755415 29 dbSNP
rs766343696 30 dbSNP
rs1336791445 31 dbSNP
rs1360235256 32 dbSNP
rs776701245 33 dbSNP
rs1287154411 34 dbSNP
rs1196043719 35 dbSNP
rs374553302 35 dbSNP
rs200025534 36 dbSNP
rs762627457 37 dbSNP
rs779268900 37 dbSNP
rs1345394159 38 dbSNP
rs763753895 39 dbSNP
rs1279318460 40 dbSNP
rs1446334813 41 dbSNP
rs1213083754 42 dbSNP
rs1249302788 44 dbSNP
rs745443833 44 dbSNP
rs188991734 45 dbSNP
rs770145679 45 dbSNP
rs756830558 46 dbSNP
rs559817267 47 dbSNP
rs1220020179 48 dbSNP
rs779647225 48 dbSNP
rs1192544800 49 dbSNP
rs1027547753 52 dbSNP
rs137854184 52 dbSNP
rs1392873365 52 dbSNP
rs755171087 52 dbSNP
rs1392660315 54 dbSNP
rs1397963208 54 dbSNP
rs983022985 55 dbSNP
rs1348132048 56 dbSNP
rs1457357803 56 dbSNP
rs1423276808 58 dbSNP
rs1423247320 60 dbSNP
rs36032671 60 dbSNP
rs908759763 60 dbSNP
rs993209148 60 dbSNP
rs1435235952 61 dbSNP
rs397515122 62 dbSNP
rs672601251 67 dbSNP
rs750251745 67 dbSNP
rs948797977 69 dbSNP
rs45498900 72 dbSNP
rs1478302208 73 dbSNP
rs1270723400 76 dbSNP
rs1277138382 77 dbSNP
rs548720772 77 dbSNP
rs886051799 78 dbSNP
rs1332550395 79 dbSNP
rs1470901735 80 dbSNP
rs1386141406 83 dbSNP
rs1365479893 85 dbSNP
rs977646071 85 dbSNP
rs1466246681 86 dbSNP
rs915706457 87 dbSNP
rs1008575454 88 dbSNP
rs941867219 89 dbSNP
rs1039094131 92 dbSNP
rs973161783 93 dbSNP
rs1431930770 97 dbSNP
rs567432587 99 dbSNP
rs918995030 100 dbSNP
rs1319785726 101 dbSNP
rs536065645 102 dbSNP
rs1051844894 103 dbSNP
rs550001058 104 dbSNP
rs1256886891 105 dbSNP
rs890728712 105 dbSNP
rs952864367 105 dbSNP
rs1346768812 107 dbSNP
rs1004345164 112 dbSNP
rs1316393843 114 dbSNP
rs34246147 115 dbSNP
rs1345608098 116 dbSNP
rs1311319790 121 dbSNP
rs1447448818 121 dbSNP
rs1376177111 124 dbSNP
rs1397997360 125 dbSNP
rs150008139 125 dbSNP
rs1172335318 126 dbSNP
rs943576288 126 dbSNP
rs1464890960 127 dbSNP
rs960266423 127 dbSNP
rs992866439 127 dbSNP
rs34379884 128 dbSNP
rs730882074 129 dbSNP
rs1483216769 131 dbSNP
rs970202456 132 dbSNP
rs1179126511 133 dbSNP
rs1198786097 134 dbSNP
rs979264685 135 dbSNP
rs1199556630 136 dbSNP
rs1345407745 139 dbSNP
rs926002084 140 dbSNP
rs1052857037 141 dbSNP
rs1240696715 141 dbSNP
rs202247051 141 dbSNP
rs894010540 141 dbSNP
rs538964708 142 dbSNP
rs558109446 144 dbSNP
rs1341260303 145 dbSNP
rs781421943 146 dbSNP
rs1333704645 148 dbSNP
rs1394525190 148 dbSNP
rs397514891 148 dbSNP
rs1362775126 149 dbSNP
rs1299264024 150 dbSNP
rs902572213 152 dbSNP
rs571731180 154 dbSNP
rs1038735192 155 dbSNP
rs1368565623 157 dbSNP
rs1003558653 159 dbSNP
rs534381681 160 dbSNP
rs1265049997 164 dbSNP
rs1217137451 168 dbSNP
rs994478294 168 dbSNP
rs1282113142 170 dbSNP
rs776059099 173 dbSNP
rs554255347 174 dbSNP
rs1004414028 175 dbSNP
rs554253529 177 dbSNP
rs1376991469 178 dbSNP
rs1012826356 179 dbSNP
rs1326057934 180 dbSNP
rs1464541497 180 dbSNP
rs1022828927 182 dbSNP
rs960359165 186 dbSNP
rs775937434 187 dbSNP
rs1162196107 188 dbSNP
rs1474012227 189 dbSNP
rs1194078522 190 dbSNP
rs1398874197 190 dbSNP
rs1240163904 191 dbSNP
rs1477348800 191 dbSNP
rs1452176020 194 dbSNP
rs368452156 194 dbSNP
rs1347011333 198 dbSNP
rs34182480 200 dbSNP
rs973194701 201 dbSNP
rs919027909 203 dbSNP
rs950491593 204 dbSNP
rs371125343 206 dbSNP
rs987163812 208 dbSNP
rs911585648 210 dbSNP
rs943040781 212 dbSNP
rs1039330269 213 dbSNP
rs35441076 218 dbSNP
rs763430709 218 dbSNP
rs1324604492 219 dbSNP
rs183689703 220 dbSNP
rs563951265 221 dbSNP
rs946885769 223 dbSNP
rs1042551574 224 dbSNP
rs1192763886 225 dbSNP
rs567880403 230 dbSNP
rs902604389 231 dbSNP
rs1266459512 232 dbSNP
rs1191706545 233 dbSNP
rs1459109429 234 dbSNP
rs1431347885 236 dbSNP
rs567025319 238 dbSNP
rs1003996646 240 dbSNP
rs978764456 242 dbSNP
rs1056551211 244 dbSNP
rs895173653 246 dbSNP
rs374108045 248 dbSNP
rs748318720 249 dbSNP
rs1012190291 250 dbSNP
rs928885380 250 dbSNP
rs1022861481 251 dbSNP
rs1352451539 251 dbSNP
rs1177932432 252 dbSNP
rs1418488339 252 dbSNP
rs1394279685 253 dbSNP
rs1156318445 254 dbSNP
rs1367036961 255 dbSNP
rs1178168657 256 dbSNP
rs1441475300 256 dbSNP
rs1479765725 256 dbSNP
rs1278648780 257 dbSNP
rs78282474 257 dbSNP
rs944671596 257 dbSNP
rs111648142 258 dbSNP
rs1222749825 259 dbSNP
rs13332377 259 dbSNP
rs930324355 260 dbSNP
rs1304175748 261 dbSNP
rs1448323908 261 dbSNP
rs570784945 261 dbSNP
rs1026534165 262 dbSNP
rs1048729638 263 dbSNP
rs1219312904 263 dbSNP
rs561630495 263 dbSNP
rs879324018 263 dbSNP
rs886213856 263 dbSNP
rs950575369 263 dbSNP
rs1214307779 264 dbSNP
rs1385472347 264 dbSNP
rs1491271779 264 dbSNP
rs1314556243 265 dbSNP
rs987659018 265 dbSNP
rs1354487874 266 dbSNP
rs1401656003 266 dbSNP
rs559752557 266 dbSNP
rs940419176 266 dbSNP
rs528508419 267 dbSNP
rs796836475 267 dbSNP
rs1196159945 268 dbSNP
rs1469733350 268 dbSNP
rs1478326984 268 dbSNP
rs542301182 268 dbSNP
rs915509688 269 dbSNP
rs1294591241 270 dbSNP
rs1371941622 270 dbSNP
rs895981838 270 dbSNP
rs946916774 270 dbSNP
rs562044040 271 dbSNP
rs142285430 272 dbSNP
rs1484079471 272 dbSNP
rs2855370 272 dbSNP
rs374706125 272 dbSNP
rs56279647 272 dbSNP
rs71827510 272 dbSNP
rs79778984 272 dbSNP
rs368632657 273 dbSNP
rs74002777 274 dbSNP
rs549700419 276 dbSNP
rs1311531741 277 dbSNP
rs200372958 278 dbSNP
rs895213866 278 dbSNP
rs1323698822 279 dbSNP
rs1012223154 280 dbSNP
rs386787811 280 dbSNP
rs762211174 280 dbSNP
rs1312722574 281 dbSNP
rs1222652018 282 dbSNP
rs754602023 282 dbSNP
rs772394688 282 dbSNP
rs867763743 283 dbSNP
rs569861397 284 dbSNP
rs201512489 287 dbSNP
rs532247261 287 dbSNP
rs1470156124 288 dbSNP
rs994676166 289 dbSNP
rs956161943 291 dbSNP
rs988846621 293 dbSNP
rs1209959991 294 dbSNP
rs778239438 295 dbSNP
rs886297772 296 dbSNP
rs1205666020 299 dbSNP
rs1349970515 300 dbSNP
rs1176232736 303 dbSNP
rs1277857563 305 dbSNP
rs187992537 306 dbSNP
rs565298575 308 dbSNP
rs1356403314 313 dbSNP
rs1293039413 317 dbSNP
rs1405567448 322 dbSNP
rs1342799987 325 dbSNP
rs577103612 328 dbSNP
rs568056589 329 dbSNP
rs568867686 330 dbSNP
rs572959816 332 dbSNP
rs984495309 337 dbSNP
rs1474073094 340 dbSNP
rs907531409 340 dbSNP
rs537187222 342 dbSNP
rs1381368270 344 dbSNP
rs758162646 345 dbSNP
rs1228996345 347 dbSNP
rs1231701088 348 dbSNP
rs974412944 349 dbSNP
rs1056230385 351 dbSNP
rs1312193120 357 dbSNP
rs1021929742 360 dbSNP
rs1320154059 360 dbSNP
rs967702702 363 dbSNP
rs1325255215 365 dbSNP
rs1258541403 367 dbSNP
rs868402230 367 dbSNP
rs978783873 368 dbSNP
rs771261310 371 dbSNP
rs1394606039 373 dbSNP
rs1163685077 374 dbSNP
rs896214489 376 dbSNP
rs191697830 379 dbSNP
rs577387279 380 dbSNP
rs1044559724 383 dbSNP
rs867318438 386 dbSNP
rs1200942487 389 dbSNP
rs1472816591 392 dbSNP
rs1180789393 393 dbSNP
rs1212054987 394 dbSNP
rs1320348921 395 dbSNP
rs916666157 396 dbSNP
rs1214394495 397 dbSNP
rs1337895323 399 dbSNP
rs777597080 400 dbSNP
rs1371003477 401 dbSNP
rs1324709579 402 dbSNP
rs1438241694 403 dbSNP
rs1038339239 404 dbSNP
rs1329261652 407 dbSNP
rs746657260 411 dbSNP
rs368013485 412 dbSNP
rs1454709740 415 dbSNP
rs1394547035 416 dbSNP
rs774921866 417 dbSNP
rs1191885624 418 dbSNP
rs1459236575 420 dbSNP
rs111786159 422 dbSNP
rs1204114312 423 dbSNP
rs891803760 427 dbSNP
rs1235658417 428 dbSNP
rs1010152405 430 dbSNP
rs553711172 431 dbSNP
rs756923313 432 dbSNP
rs1279712589 433 dbSNP
rs966125943 433 dbSNP
rs1173234001 435 dbSNP
rs886332968 436 dbSNP
rs1352541452 437 dbSNP
rs1314557101 438 dbSNP
rs1009159039 439 dbSNP
rs3743870 440 dbSNP
rs1424855757 442 dbSNP
rs996440305 446 dbSNP
rs1465457113 448 dbSNP
rs1028824293 449 dbSNP
rs1018745193 452 dbSNP
rs768097806 457 dbSNP
rs951976370 460 dbSNP
rs1278764122 461 dbSNP
rs1485612752 461 dbSNP
rs900255572 462 dbSNP
rs995965746 464 dbSNP
rs1284427532 465 dbSNP
rs1222839520 467 dbSNP
rs1022045835 469 dbSNP
rs984714341 469 dbSNP
rs1294871627 472 dbSNP
rs967735315 473 dbSNP
rs780683017 474 dbSNP
rs917690037 475 dbSNP
rs573226497 476 dbSNP
rs1345853942 478 dbSNP
rs542240060 480 dbSNP
rs1158546067 481 dbSNP
rs577209727 481 dbSNP
rs1420343599 482 dbSNP
rs947813833 482 dbSNP
rs1044995706 484 dbSNP
rs927473939 485 dbSNP
rs1317019506 487 dbSNP
rs1216604235 491 dbSNP
rs1214502012 492 dbSNP
rs1314645231 494 dbSNP
rs776141886 496 dbSNP
rs1274605142 497 dbSNP
rs977769185 499 dbSNP
rs1233535642 502 dbSNP
rs371496391 504 dbSNP
rs960961194 505 dbSNP
rs1383841911 509 dbSNP
rs1280562010 511 dbSNP
rs1288334335 513 dbSNP
rs992746427 514 dbSNP
rs936136687 515 dbSNP
rs3087631 517 dbSNP
rs892023610 521 dbSNP
rs1235286089 522 dbSNP
rs1429595075 525 dbSNP
rs1261589936 528 dbSNP
rs544713931 531 dbSNP
rs1185305742 532 dbSNP
rs1463113897 537 dbSNP
rs776172110 538 dbSNP
rs563305714 539 dbSNP
rs901964044 541 dbSNP
rs1271018020 546 dbSNP
rs974154277 547 dbSNP
rs1212750775 548 dbSNP
rs749851663 549 dbSNP
rs532185158 550 dbSNP
rs769130086 551 dbSNP
rs764840200 552 dbSNP
rs774922931 552 dbSNP
rs762029876 553 dbSNP
rs1300143432 554 dbSNP
rs961944453 555 dbSNP
rs1175405885 565 dbSNP
rs1357548708 566 dbSNP
rs1372878470 567 dbSNP
rs1168866134 569 dbSNP
rs944599331 570 dbSNP
rs1040691772 571 dbSNP
rs772899303 572 dbSNP
rs995998310 574 dbSNP
rs2854588 575 dbSNP
rs1264780194 576 dbSNP
rs1397901251 576 dbSNP
rs980553044 577 dbSNP
rs1250555041 578 dbSNP
rs924992457 581 dbSNP
rs1350023749 583 dbSNP
rs1233605223 584 dbSNP
rs936190439 585 dbSNP
rs1345592862 591 dbSNP
rs1218626538 594 dbSNP
rs1276450855 597 dbSNP
rs1396214248 597 dbSNP
rs1437103279 599 dbSNP
rs1355180878 600 dbSNP
rs1043518994 602 dbSNP
rs183979118 603 dbSNP
rs565636902 604 dbSNP
rs1375443119 606 dbSNP
rs1487136580 608 dbSNP
rs946283973 609 dbSNP
rs1191477301 615 dbSNP
rs556570291 616 dbSNP
rs1249530471 618 dbSNP
rs1179796466 619 dbSNP
rs773297182 621 dbSNP
rs1210090435 625 dbSNP
rs1342874893 626 dbSNP
rs1262632179 627 dbSNP
rs1335453578 630 dbSNP
rs1478628296 630 dbSNP
rs999612084 632 dbSNP
rs1356530770 633 dbSNP
rs1030634516 635 dbSNP
rs1312745441 640 dbSNP
rs528412312 642 dbSNP
rs1013879243 644 dbSNP
rs1421519298 646 dbSNP
rs1159339894 648 dbSNP
rs1023827234 651 dbSNP
rs1156532485 656 dbSNP
rs969550464 657 dbSNP
rs1257967786 660 dbSNP
rs1187127746 662 dbSNP
rs1440683686 663 dbSNP
rs1205840255 669 dbSNP
rs974186957 669 dbSNP
rs887834107 672 dbSNP
rs920022480 673 dbSNP
rs1266421244 676 dbSNP
rs547863566 678 dbSNP
rs373639226 679 dbSNP
rs1382248077 681 dbSNP
rs367951136 681 dbSNP
rs762793687 681 dbSNP
rs912603398 681 dbSNP
rs1383632228 685 dbSNP
rs1013493799 687 dbSNP
rs897787085 687 dbSNP
rs944028454 688 dbSNP
rs568078250 689 dbSNP
rs1025276182 690 dbSNP
rs1331423414 690 dbSNP
rs545371620 691 dbSNP
rs1374687403 693 dbSNP
rs190152551 695 dbSNP
rs921828318 696 dbSNP
rs766489027 697 dbSNP
rs752613073 698 dbSNP
rs1043550238 699 dbSNP
rs957770047 701 dbSNP
rs990301126 702 dbSNP
rs903614823 703 dbSNP
rs999245923 704 dbSNP
rs1052613746 706 dbSNP
rs946172953 708 dbSNP
rs758383845 709 dbSNP
rs181780746 710 dbSNP
rs1290175680 713 dbSNP
rs1394818339 714 dbSNP
rs1322515397 716 dbSNP
rs923495188 719 dbSNP
rs540040398 720 dbSNP
rs1221299997 723 dbSNP
rs1050406101 725 dbSNP
rs887887822 726 dbSNP
rs1251612403 727 dbSNP
rs1388388206 727 dbSNP
rs1195619933 729 dbSNP
rs942093738 733 dbSNP
rs1252554414 738 dbSNP
rs1442160215 739 dbSNP
rs1036227896 740 dbSNP
rs1274228192 745 dbSNP
rs187331220 748 dbSNP
rs1013795627 749 dbSNP
rs573566934 749 dbSNP
rs751313275 750 dbSNP
rs756873400 752 dbSNP
rs73498118 753 dbSNP
rs982921818 754 dbSNP
rs912624205 756 dbSNP
rs1368587863 759 dbSNP
rs752234831 764 dbSNP
rs1435354719 765 dbSNP
rs1001905592 766 dbSNP
rs555453899 767 dbSNP
rs575611619 768 dbSNP
rs975387518 769 dbSNP
rs957822502 770 dbSNP
rs921861004 777 dbSNP
rs987859249 780 dbSNP
rs1020622120 781 dbSNP
rs1283034920 788 dbSNP
rs544340999 789 dbSNP
rs564609458 790 dbSNP
rs745341634 800 dbSNP
rs1277385607 807 dbSNP
rs925181097 810 dbSNP
rs1333424347 812 dbSNP
rs1408939851 813 dbSNP
rs755653968 814 dbSNP
rs1314572263 815 dbSNP
rs1246387958 816 dbSNP
rs1284354761 819 dbSNP
rs935155314 820 dbSNP
rs181814805 821 dbSNP
rs896198372 822 dbSNP
rs1158739459 823 dbSNP
rs1271709209 823 dbSNP
rs949067437 831 dbSNP
rs1044675322 832 dbSNP
rs545586456 833 dbSNP
rs1485665373 834 dbSNP
rs559158862 835 dbSNP
rs1207464260 840 dbSNP
rs995753401 840 dbSNP
rs1436089216 842 dbSNP
rs909207729 845 dbSNP
rs779759485 847 dbSNP
rs752472135 849 dbSNP
rs941974355 849 dbSNP
rs1004771537 850 dbSNP
rs1472632292 851 dbSNP
rs528351015 852 dbSNP
rs1162488321 853 dbSNP
rs766153620 853 dbSNP
rs919309114 853 dbSNP
rs1425565939 854 dbSNP
rs949259809 858 dbSNP
rs1046644604 860 dbSNP
rs1320066659 862 dbSNP
rs1330544126 865 dbSNP
rs905132047 868 dbSNP
rs139573366 874 dbSNP
rs769291648 875 dbSNP
rs1412197969 879 dbSNP
rs1053597274 882 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site CDS
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.639 1.2e-3 -0.602 2.5e-3 20 Click to see details
GSE28544 Breast cancer 0.519 4.7e-3 0.523 4.4e-3 24 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.427 1.3e-1 0.433 1.2e-1 9 Click to see details
GSE26953 Aortic valvular endothelial cells -0.236 1.3e-1 -0.290 8.5e-2 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.224 1.4e-1 -0.274 9.3e-2 25 Click to see details
GSE17498 Multiple myeloma 0.156 1.7e-1 0.295 3.2e-2 40 Click to see details
GSE19783 ER+ ER+ breast cancer -0.222 1.7e-1 -0.146 2.7e-1 20 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.185 1.9e-1 0.089 3.4e-1 25 Click to see details
GSE38226 Liver fibrosis 0.175 2.2e-1 0.219 1.7e-1 21 Click to see details
GSE21032 Prostate cancer 0.038 3.7e-1 -0.042 3.5e-1 83 Click to see details
GSE19536 Breast cancer 0.033 3.7e-1 0.004 4.8e-1 100 Click to see details
GSE21687 Ependynoma primary tumors -0.036 3.9e-1 0.048 3.5e-1 64 Click to see details
GSE28260 Renal cortex and medulla -0.064 4.2e-1 -0.137 3.3e-1 13 Click to see details
GSE19350 CNS germ cell tumors -0.035 4.6e-1 0.182 2.9e-1 12 Click to see details
GSE42095 Differentiated embryonic stem cells -0.02 4.6e-1 -0.096 3.3e-1 23 Click to see details
GSE19783 ER- ER- breast cancer -0.005 4.8e-1 -0.045 3.5e-1 79 Click to see details
GSE32688 Pancreatic cancer 0.005 4.9e-1 0.045 4.0e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
PRAD 0.363 0 0.234 0.05 50 Click to see details
CHOL -0.68 0.02 -0.417 0.13 9 Click to see details
LUSC -0.304 0.03 -0.242 0.07 38 Click to see details
THCA 0.226 0.04 0.313 0.01 59 Click to see details
PCPG 0.959 0.09 0.500 0.33 3 Click to see details
COAD -0.483 0.11 -0.595 0.06 8 Click to see details
BRCA -0.131 0.12 -0.121 0.14 84 Click to see details
KIRC -0.093 0.23 -0.064 0.3 68 Click to see details
LUAD 0.224 0.24 0.203 0.26 12 Click to see details
UCEC 0.157 0.26 0.163 0.25 19 Click to see details
CESC 0.667 0.27 1.000 0.5 3 Click to see details
BLCA -0.154 0.27 0.015 0.48 18 Click to see details
ESCA -0.2 0.28 -0.255 0.22 11 Click to see details
KICH -0.075 0.36 0.115 0.29 25 Click to see details
PAAD 0.246 0.38 -0.400 0.3 4 Click to see details
LIHC -0.034 0.41 0.016 0.46 49 Click to see details
STAD 0.041 0.41 -0.244 0.09 32 Click to see details
HNSC -0.009 0.48 -0.059 0.36 42 Click to see details
KIRP 0.01 0.48 0.150 0.21 32 Click to see details
KIRP 0.01 0.48 0.150 0.21 32 Click to see details
KIRP 0.01 0.48 0.150 0.21 32 Click to see details
412 hsa-miR-744-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT016085 ARL15 ADP ribosylation factor like GTPase 15 1 1
MIRT016086 AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 1 2
MIRT016087 PPTC7 PTC7 protein phosphatase homolog 2 3
MIRT016088 RASSF1 Ras association domain family member 1 1 1
MIRT016089 IER5 immediate early response 5 1 1
MIRT037383 UFC1 ubiquitin-fold modifier conjugating enzyme 1 1 1
MIRT037384 STAM2 signal transducing adaptor molecule 2 1 1
MIRT037385 SRRM2 serine/arginine repetitive matrix 2 1 1
MIRT037386 DCXR dicarbonyl and L-xylulose reductase 1 1
MIRT037387 TSPAN17 tetraspanin 17 1 1
MIRT037388 ACTB actin beta 1 1
MIRT037389 HIST1H2BC histone cluster 1 H2B family member c 1 1
MIRT037390 ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 1 1
MIRT037391 VDAC1 voltage dependent anion channel 1 1 1
MIRT037392 RNASEK ribonuclease K 1 1
MIRT037393 CDK16 cyclin dependent kinase 16 1 1
MIRT037394 ZCCHC24 zinc finger CCHC-type containing 24 1 1
MIRT037395 ARRDC2 arrestin domain containing 2 1 1
MIRT037396 SGMS1 sphingomyelin synthase 1 1 1
MIRT037397 HSPD1 heat shock protein family D (Hsp60) member 1 1 1
MIRT037398 MRPL46 mitochondrial ribosomal protein L46 1 1
MIRT037399 RHEB Ras homolog, mTORC1 binding 1 1
MIRT037400 ND1 NADH dehydrogenase, subunit 1 (complex I) 1 1
MIRT037401 TP53I13 tumor protein p53 inducible protein 13 1 1
MIRT037402 CD44 CD44 molecule (Indian blood group) 1 1
MIRT037403 USP12 ubiquitin specific peptidase 12 1 1
MIRT037404 AP2B1 adaptor related protein complex 2 beta 1 subunit 1 1
MIRT037405 RPL18A ribosomal protein L18a 1 1
MIRT037406 PPP1CA protein phosphatase 1 catalytic subunit alpha 1 1
MIRT037407 TNRC6B trinucleotide repeat containing 6B 1 1
MIRT037408 PXK PX domain containing serine/threonine kinase like 1 1
MIRT037409 TDRKH tudor and KH domain containing 1 1
MIRT037410 PRRC2A proline rich coiled-coil 2A 1 1
MIRT037411 ATP11A ATPase phospholipid transporting 11A 1 1
MIRT037412 NDE1 nudE neurodevelopment protein 1 1 1
MIRT037413 STK16 serine/threonine kinase 16 1 1
MIRT037414 PSMB2 proteasome subunit beta 2 1 1
MIRT037415 EPN1 epsin 1 1 1
MIRT037416 EN2 engrailed homeobox 2 1 1
MIRT037417 LARP1 La ribonucleoprotein domain family member 1 1 1
MIRT037418 SRCAP Snf2 related CREBBP activator protein 1 1
MIRT037419 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 1 1
MIRT037420 AP2A2 adaptor related protein complex 2 alpha 2 subunit 1 1
MIRT037421 ACTG1 actin gamma 1 1 1
MIRT037422 PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing 1 1
MIRT037423 UBE2O ubiquitin conjugating enzyme E2 O 1 1
MIRT037424 KLHL15 kelch like family member 15 1 1
MIRT037425 SECISBP2 SECIS binding protein 2 1 1
MIRT037426 KIAA0922 transmembrane 131 like 1 1
MIRT037427 PTMA prothymosin, alpha 1 1
MIRT037428 WDR45B WD repeat domain 45B 1 1
MIRT037429 ZNF282 zinc finger protein 282 1 1
MIRT037430 GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 1 1
MIRT037431 TNKS tankyrase 1 1
MIRT037432 NOP2 NOP2 nucleolar protein 1 1
MIRT037433 GAK cyclin G associated kinase 1 1
MIRT037434 ATP6 ATP synthase F0 subunit 6 1 1
MIRT037435 DIDO1 death inducer-obliterator 1 1 1
MIRT037436 RPL3 ribosomal protein L3 1 1
MIRT037437 AIMP2 aminoacyl tRNA synthetase complex interacting multifunctional protein 2 1 1
MIRT037438 PIGC phosphatidylinositol glycan anchor biosynthesis class C 1 1
MIRT037439 ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 1 1
MIRT037440 USP21 ubiquitin specific peptidase 21 1 1
MIRT037441 NUFIP2 NUFIP2, FMR1 interacting protein 2 1 1
MIRT037442 RPS6 ribosomal protein S6 1 1
MIRT037443 ILKAP ILK associated serine/threonine phosphatase 1 1
MIRT037444 COX1 cytochrome c oxidase subunit I 1 1
MIRT037445 VPS37C VPS37C, ESCRT-I subunit 1 1
MIRT037446 CDK12 cyclin dependent kinase 12 1 1
MIRT037447 RBM8A RNA binding motif protein 8A 1 1
MIRT037448 CKB creatine kinase B 1 1
MIRT037449 DHX57 DExH-box helicase 57 1 1
MIRT037450 DDX23 DEAD-box helicase 23 1 1
MIRT037451 ABI3 ABI family member 3 1 1
MIRT037452 GATAD2B GATA zinc finger domain containing 2B 1 1
MIRT037453 PDPK1 3-phosphoinositide dependent protein kinase 1 1 1
MIRT037454 C17orf70 Fanconi anemia core complex associated protein 100 1 1
MIRT037455 SKI SKI proto-oncogene 1 1
MIRT037456 KCTD11 potassium channel tetramerization domain containing 11 1 1
MIRT037457 GNB2L1 receptor for activated C kinase 1 1 1
MIRT037458 NCOA3 nuclear receptor coactivator 3 1 1
MIRT037459 PAK4 p21 (RAC1) activated kinase 4 2 3
MIRT037460 GDI2 GDP dissociation inhibitor 2 1 1
MIRT037461 SLC2A4RG SLC2A4 regulator 1 1
MIRT037462 SLX4 SLX4 structure-specific endonuclease subunit 1 1
MIRT037463 COPA coatomer protein complex subunit alpha 1 1
MIRT037464 GPRASP2 G protein-coupled receptor associated sorting protein 2 1 1
MIRT037465 GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 1 1
MIRT037466 LIMS1 LIM zinc finger domain containing 1 1 1
MIRT037467 COTL1 coactosin like F-actin binding protein 1 1 1
MIRT037468 CAPNS1 calpain small subunit 1 1 1
MIRT037469 FRZB frizzled-related protein 1 1
MIRT037470 UBQLN4 ubiquilin 4 1 1
MIRT037471 NUP153 nucleoporin 153 1 1
MIRT037472 TMEM175 transmembrane protein 175 1 1
MIRT037473 HIST1H2BD histone cluster 1 H2B family member d 1 1
MIRT037474 SREBF1 sterol regulatory element binding transcription factor 1 1 1
MIRT037475 BCL2L12 BCL2 like 12 1 1
MIRT037476 HIST2H2AA3 histone cluster 2 H2A family member a3 1 1
MIRT037477 MINK1 misshapen like kinase 1 1 1
MIRT037478 PDXK pyridoxal kinase 1 1
MIRT037479 FAM110A family with sequence similarity 110 member A 1 1
MIRT037480 ZNF598 zinc finger protein 598 1 1
MIRT037481 ILK integrin linked kinase 1 1
MIRT037482 HINT1 histidine triad nucleotide binding protein 1 1 1
MIRT037483 WBP2 WW domain binding protein 2 1 1
MIRT037484 CYTB cytochrome b 1 1
MIRT037485 SCAMP2 secretory carrier membrane protein 2 1 1
MIRT037486 TRIM33 tripartite motif containing 33 1 1
MIRT037487 SLC25A3 solute carrier family 25 member 3 1 1
MIRT037488 IRS4 insulin receptor substrate 4 1 1
MIRT037489 TSR1 TSR1, ribosome maturation factor 1 1
MIRT037490 TCOF1 treacle ribosome biogenesis factor 1 1 1
MIRT037491 ATXN2L ataxin 2 like 1 1
MIRT037492 MTOR mechanistic target of rapamycin kinase 1 1
MIRT037493 ZNF318 zinc finger protein 318 1 1
MIRT037494 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 3
MIRT037495 SAMD4B sterile alpha motif domain containing 4B 1 1
MIRT037496 STMN1 stathmin 1 1 1
MIRT037497 SAT1 spermidine/spermine N1-acetyltransferase 1 1 1
MIRT037498 SALL1 spalt like transcription factor 1 1 1
MIRT037499 ZSCAN18 zinc finger and SCAN domain containing 18 1 1
MIRT037500 SLC35D1 solute carrier family 35 member D1 1 1
MIRT037501 TM9SF3 transmembrane 9 superfamily member 3 1 1
MIRT037502 TIAM1 T-cell lymphoma invasion and metastasis 1 1 1
MIRT037503 CHD5 chromodomain helicase DNA binding protein 5 1 1
MIRT037504 BAG6 BCL2 associated athanogene 6 1 1
MIRT037505 MED28 mediator complex subunit 28 1 1
MIRT037506 ANKRD52 ankyrin repeat domain 52 1 1
MIRT037507 MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 1 1
MIRT037508 PPDPF pancreatic progenitor cell differentiation and proliferation factor 1 1
MIRT037509 PRKACA protein kinase cAMP-activated catalytic subunit alpha 1 1
MIRT037510 HPCAL4 hippocalcin like 4 1 1
MIRT037511 ZNF256 zinc finger protein 256 1 1
MIRT037512 CGNL1 cingulin like 1 1 1
MIRT037513 TUBA1B tubulin alpha 1b 1 1
MIRT037514 LNPEP leucyl and cystinyl aminopeptidase 1 1
MIRT037515 PDE4A phosphodiesterase 4A 1 1
MIRT037516 HOXD11 homeobox D11 2 3
MIRT037517 QARS glutaminyl-tRNA synthetase 1 1
MIRT037518 G3BP1 G3BP stress granule assembly factor 1 1 1
MIRT037519 PLEKHM2 pleckstrin homology and RUN domain containing M2 1 1
MIRT037520 POLR2A RNA polymerase II subunit A 1 1
MIRT037521 KIAA1462 junctional cadherin 5 associated 1 1
MIRT037522 SF3A1 splicing factor 3a subunit 1 1 1
MIRT037523 YBX1 Y-box binding protein 1 1 1
MIRT037524 PTGES3 prostaglandin E synthase 3 1 1
MIRT037525 FOXO3 forkhead box O3 1 1
MIRT037526 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 1 1
MIRT037527 AARS alanyl-tRNA synthetase 1 1
MIRT037528 ZNF155 zinc finger protein 155 1 1
MIRT037529 NCS1 neuronal calcium sensor 1 1 1
MIRT037530 FKBP4 FK506 binding protein 4 1 1
MIRT037531 ARHGDIA Rho GDP dissociation inhibitor alpha 1 1
MIRT037532 MAPK7 mitogen-activated protein kinase 7 1 1
MIRT037533 AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 1 1
MIRT037534 HIST1H1E histone cluster 1 H1 family member e 1 1
MIRT037535 MLF2 myeloid leukemia factor 2 1 1
MIRT037536 EDC3 enhancer of mRNA decapping 3 1 1
MIRT037537 CHRAC1 chromatin accessibility complex 1 1 1
MIRT037538 WIPF3 WAS/WASL interacting protein family member 3 1 1
MIRT037539 COX2 cytochrome c oxidase subunit II 1 1
MIRT037540 SRSF1 serine and arginine rich splicing factor 1 1 1
MIRT037541 CTNNBIP1 catenin beta interacting protein 1 1 1
MIRT037542 RPL4 ribosomal protein L4 1 1
MIRT037543 COX3 cytochrome c oxidase III 1 1
MIRT037544 DDX54 DEAD-box helicase 54 1 1
MIRT037545 TOB2 transducer of ERBB2, 2 1 1
MIRT037546 MAN2C1 mannosidase alpha class 2C member 1 1 1
MIRT037547 SMCR7L mitochondrial elongation factor 1 1 1
MIRT037548 RPLP1 ribosomal protein lateral stalk subunit P1 1 1
MIRT037549 RAN RAN, member RAS oncogene family 1 1
MIRT037550 NONO non-POU domain containing octamer binding 1 1
MIRT037551 CYB5R3 cytochrome b5 reductase 3 1 1
MIRT037552 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 1 1
MIRT037553 COLGALT1 collagen beta(1-O)galactosyltransferase 1 1 1
MIRT037554 MGRN1 mahogunin ring finger 1 1 1
MIRT037555 ANAPC1 anaphase promoting complex subunit 1 1 1
MIRT037556 TBX1 T-box 1 1 1
MIRT037557 NXPH4 neurexophilin 4 1 1
MIRT037558 HSPA1B heat shock protein family A (Hsp70) member 1B 1 1
MIRT037559 UBE2A ubiquitin conjugating enzyme E2 A 1 1
MIRT037560 KPNB1 karyopherin subunit beta 1 1 1
MIRT037561 NDUFB10 NADH:ubiquinone oxidoreductase subunit B10 1 1
MIRT037562 SYMPK symplekin 1 1
MIRT037563 SYPL1 synaptophysin like 1 1 1
MIRT037564 LRP3 LDL receptor related protein 3 1 1
MIRT037565 DDX24 DEAD-box helicase 24 1 1
MIRT037566 WDR37 WD repeat domain 37 1 1
MIRT037567 RPS14 ribosomal protein S14 1 1
MIRT037568 FAM53C family with sequence similarity 53 member C 1 1
MIRT037569 NMT1 N-myristoyltransferase 1 1 1
MIRT037570 PAGR1 PAXIP1 associated glutamate rich protein 1 1 1
MIRT037571 AKT2 AKT serine/threonine kinase 2 1 1
MIRT037572 TMEM14C transmembrane protein 14C 1 1
MIRT037573 MEX3D mex-3 RNA binding family member D 1 1
MIRT037574 BRAF B-Raf proto-oncogene, serine/threonine kinase 1 1
MIRT037575 POLR2L RNA polymerase II subunit L 1 1
MIRT037576 SERP1 stress associated endoplasmic reticulum protein 1 1 1
MIRT037577 C8orf33 chromosome 8 open reading frame 33 1 1
MIRT037578 NR1D2 nuclear receptor subfamily 1 group D member 2 1 1
MIRT037579 POLD3 DNA polymerase delta 3, accessory subunit 1 1
MIRT037580 HMGA1 high mobility group AT-hook 1 1 1
MIRT037581 SLC35B4 solute carrier family 35 member B4 1 1
MIRT037582 PELP1 proline, glutamate and leucine rich protein 1 1 1
MIRT037583 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 1 1
MIRT037584 RPL7A ribosomal protein L7a 1 1
MIRT037585 LAIR1 leukocyte associated immunoglobulin like receptor 1 1 1
MIRT037586 RPL10 ribosomal protein L10 1 1
MIRT037587 MRPS16 mitochondrial ribosomal protein S16 1 1
MIRT037588 SRM spermidine synthase 1 1
MIRT037589 EIF3K eukaryotic translation initiation factor 3 subunit K 1 1
MIRT037590 DESI1 desumoylating isopeptidase 1 1 1
MIRT037591 BET1 Bet1 golgi vesicular membrane trafficking protein 1 1
MIRT037592 HTRA2 HtrA serine peptidase 2 1 1
MIRT037593 LARP6 La ribonucleoprotein domain family member 6 1 1
MIRT037594 NOTCH2 notch 2 1 1
MIRT037595 ADCY9 adenylate cyclase 9 1 1
MIRT037596 C6orf62 chromosome 6 open reading frame 62 1 1
MIRT037597 FBXL19 F-box and leucine rich repeat protein 19 1 1
MIRT037598 L3MBTL2 L3MBTL2, polycomb repressive complex 1 subunit 1 1
MIRT037599 TRIM28 tripartite motif containing 28 1 1
MIRT037600 LGALS3 galectin 3 1 1
MIRT037601 IGSF8 immunoglobulin superfamily member 8 1 1
MIRT037602 LIN37 lin-37 DREAM MuvB core complex component 1 1
MIRT037603 PTPRF protein tyrosine phosphatase, receptor type F 1 1
MIRT037604 MTSS1L MTSS1L, I-BAR domain containing 1 1
MIRT037605 TRMT2A tRNA methyltransferase 2 homolog A 1 1
MIRT037606 DVL1 dishevelled segment polarity protein 1 1 1
MIRT037607 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 1 1
MIRT037608 TOR2A torsin family 2 member A 1 1
MIRT037609 RPS6KA5 ribosomal protein S6 kinase A5 1 1
MIRT037610 SMYD4 SET and MYND domain containing 4 1 1
MIRT037611 TJAP1 tight junction associated protein 1 1 1
MIRT037612 IRAK1 interleukin 1 receptor associated kinase 1 1 1
MIRT037613 PPM1M protein phosphatase, Mg2+/Mn2+ dependent 1M 1 1
MIRT037614 EIF4A2 eukaryotic translation initiation factor 4A2 1 1
MIRT037615 GFER growth factor, augmenter of liver regeneration 1 1
MIRT037616 PKP2 plakophilin 2 1 1
MIRT037617 FARSB phenylalanyl-tRNA synthetase beta subunit 1 1
MIRT037618 OPRD1 opioid receptor delta 1 1 1
MIRT037619 CCNY cyclin Y 1 1
MIRT037620 CNOT1 CCR4-NOT transcription complex subunit 1 1 1
MIRT037621 CXCL16 C-X-C motif chemokine ligand 16 1 1
MIRT037622 CEBPA CCAAT/enhancer binding protein alpha 1 1
MIRT037623 DDX11 DEAD/H-box helicase 11 1 1
MIRT037624 URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 1 1
MIRT037625 SBF1 SET binding factor 1 1 1
MIRT037626 GNB2 G protein subunit beta 2 1 1
MIRT037627 KMT2D lysine methyltransferase 2D 2 3
MIRT037628 DDX17 DEAD-box helicase 17 1 1
MIRT037629 SORBS3 sorbin and SH3 domain containing 3 1 1
MIRT037630 TAPBP TAP binding protein 1 1
MIRT037631 BCR BCR, RhoGEF and GTPase activating protein 1 1
MIRT037632 RPL18 ribosomal protein L18 1 1
MIRT037633 INTS3 integrator complex subunit 3 1 1
MIRT037634 CDC25B cell division cycle 25B 1 1
MIRT037635 LDOC1L retrotransposon Gag like 6 1 1
MIRT037636 TUB tubby bipartite transcription factor 1 1
MIRT037637 NUDT2 nudix hydrolase 2 1 1
MIRT037638 CDAN1 codanin 1 1 1
MIRT037639 MRS2 MRS2, magnesium transporter 1 1
MIRT037640 PYGB glycogen phosphorylase B 1 1
MIRT037641 LDLRAD3 low density lipoprotein receptor class A domain containing 3 1 1
MIRT037642 COL5A1 collagen type V alpha 1 chain 1 1
MIRT037643 ATF7IP activating transcription factor 7 interacting protein 1 1
MIRT037644 AGO1 argonaute 1, RISC catalytic component 1 1
MIRT037645 ZNF212 zinc finger protein 212 1 1
MIRT037646 TSC2 TSC complex subunit 2 1 1
MIRT037647 FASN fatty acid synthase 1 1
MIRT037648 NOL9 nucleolar protein 9 1 1
MIRT037649 CLUH clustered mitochondria homolog 1 1
MIRT037650 PHF8 PHD finger protein 8 1 1
MIRT037651 EIF4G1 eukaryotic translation initiation factor 4 gamma 1 1 1
MIRT037652 TRAPPC12 trafficking protein particle complex 12 1 1
MIRT037653 HOXC11 homeobox C11 1 1
MIRT037654 DGCR14 ess-2 splicing factor homolog 1 1
MIRT037655 SLC25A1 solute carrier family 25 member 1 1 1
MIRT037656 MEX3C mex-3 RNA binding family member C 1 1
MIRT037657 RAI1 retinoic acid induced 1 1 1
MIRT037658 LY6E lymphocyte antigen 6 family member E 1 1
MIRT037659 SEC16A SEC16 homolog A, endoplasmic reticulum export factor 1 1
MIRT037660 RPL37 ribosomal protein L37 1 1
MIRT037661 CNN2 calponin 2 1 1
MIRT037662 ALDH18A1 aldehyde dehydrogenase 18 family member A1 1 1
MIRT037663 POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 1 1
MIRT037664 EIF4A1 eukaryotic translation initiation factor 4A1 1 1
MIRT037665 PIM3 Pim-3 proto-oncogene, serine/threonine kinase 1 1
MIRT037666 PTPMT1 protein tyrosine phosphatase, mitochondrial 1 1 1
MIRT037667 NCEH1 neutral cholesterol ester hydrolase 1 1 1
MIRT037668 ART5 ADP-ribosyltransferase 5 1 1
MIRT037669 MRPS2 mitochondrial ribosomal protein S2 1 1
MIRT037670 NCL nucleolin 1 1
MIRT037671 NCKAP5L NCK associated protein 5 like 1 1
MIRT037672 ZCCHC14 zinc finger CCHC-type containing 14 1 1
MIRT037673 CCDC71 coiled-coil domain containing 71 1 1
MIRT037674 SURF4 surfeit 4 1 1
MIRT037675 RPL13 ribosomal protein L13 1 1
MIRT037676 ACTN4 actinin alpha 4 1 1
MIRT037677 PA2G4 proliferation-associated 2G4 1 1
MIRT037678 MIF macrophage migration inhibitory factor 1 1
MIRT037679 UBE2N ubiquitin conjugating enzyme E2 N 1 1
MIRT037680 LYNX1 Ly6/neurotoxin 1 1 1
MIRT037681 TACC3 transforming acidic coiled-coil containing protein 3 1 1
MIRT037682 GSR glutathione-disulfide reductase 1 1
MIRT037683 GSK3A glycogen synthase kinase 3 alpha 1 1
MIRT037684 ZMYM3 zinc finger MYM-type containing 3 1 1
MIRT037685 ERP29 endoplasmic reticulum protein 29 1 1
MIRT037686 MATR3 matrin 3 1 1
MIRT037687 FANCG Fanconi anemia complementation group G 1 1
MIRT037688 FAM83G family with sequence similarity 83 member G 1 1
MIRT037689 DUSP18 dual specificity phosphatase 18 1 1
MIRT037690 MYC MYC proto-oncogene, bHLH transcription factor 3 2
MIRT037691 TSPAN7 tetraspanin 7 1 1
MIRT037692 ATMIN ATM interactor 1 1
MIRT037693 SEPT2 septin 2 1 1
MIRT037694 FOXRED2 FAD dependent oxidoreductase domain containing 2 1 1
MIRT037695 TECR trans-2,3-enoyl-CoA reductase 1 1
MIRT037696 MRPL11 mitochondrial ribosomal protein L11 1 1
MIRT037697 IP6K1 inositol hexakisphosphate kinase 1 1 1
MIRT037698 PSMD4 proteasome 26S subunit, non-ATPase 4 1 1
MIRT037699 SH3GL1 SH3 domain containing GRB2 like 1, endophilin A2 1 1
MIRT037700 CTNNB1 catenin beta 1 1 1
MIRT037701 TMEM189 transmembrane protein 189 1 1
MIRT037702 LDLR low density lipoprotein receptor 1 1
MIRT037703 OGFR opioid growth factor receptor 1 1
MIRT037704 ADAP2 ArfGAP with dual PH domains 2 1 1
MIRT037705 LIPA lipase A, lysosomal acid type 1 1
MIRT037706 SNAPC4 small nuclear RNA activating complex polypeptide 4 1 1
MIRT037707 FBN2 fibrillin 2 1 1
MIRT037708 ZNF704 zinc finger protein 704 1 1
MIRT037709 EIF3M eukaryotic translation initiation factor 3 subunit M 1 1
MIRT037710 SMC1A structural maintenance of chromosomes 1A 1 1
MIRT037711 FZR1 fizzy and cell division cycle 20 related 1 1 1
MIRT037712 NANOS1 nanos C2HC-type zinc finger 1 1 1
MIRT037713 PRR12 proline rich 12 1 1
MIRT037714 PHC2 polyhomeotic homolog 2 1 1
MIRT037715 NOP9 NOP9 nucleolar protein 1 1
MIRT037716 HM13 histocompatibility minor 13 1 1
MIRT037717 PRDX5 peroxiredoxin 5 1 1
MIRT037718 IRGQ immunity related GTPase Q 1 1
MIRT037719 TGFB1 transforming growth factor beta 1 7 2
MIRT037720 MARCH3 membrane associated ring-CH-type finger 3 1 1
MIRT037721 TBX2 T-box 2 1 1
MIRT037722 TSC22D3 TSC22 domain family member 3 1 1
MIRT037723 DUT deoxyuridine triphosphatase 1 1
MIRT037724 FAM171A2 family with sequence similarity 171 member A2 1 1
MIRT037725 FGFR1 fibroblast growth factor receptor 1 1 1
MIRT037726 FRAT1 FRAT1, WNT signaling pathway regulator 1 1
MIRT037727 PSMD11 proteasome 26S subunit, non-ATPase 11 1 1
MIRT037728 PABPC1 poly(A) binding protein cytoplasmic 1 1 1
MIRT037729 ENO1 enolase 1 1 1
MIRT037730 AP3D1 adaptor related protein complex 3 delta 1 subunit 1 1
MIRT037731 TUBA1A tubulin alpha 1a 1 1
MIRT037732 ULK3 unc-51 like kinase 3 1 1
MIRT037733 PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha 1 1
MIRT037734 SLC25A46 solute carrier family 25 member 46 1 1
MIRT037735 MED15 mediator complex subunit 15 1 1
MIRT037736 IRF2BP1 interferon regulatory factor 2 binding protein 1 1 1
MIRT037737 UBA1 ubiquitin like modifier activating enzyme 1 1 1
MIRT037738 ATHL1 protein-glucosylgalactosylhydroxylysine glucosidase 1 1
MIRT037739 CTNNA1 catenin alpha 1 1 1
MIRT037740 ADRM1 adhesion regulating molecule 1 1 1
MIRT037741 CCDC106 coiled-coil domain containing 106 1 1
MIRT054493 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 3 1
MIRT451195 PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 2 2
MIRT452931 DISC1 disrupted in schizophrenia 1 2 2
MIRT455468 LYPLA2 lysophospholipase II 2 2
MIRT457068 TOR4A torsin family 4 member A 2 2
MIRT464195 VGLL4 vestigial like family member 4 2 4
MIRT483030 KHSRP KH-type splicing regulatory protein 2 4
MIRT486062 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT486120 INO80E INO80 complex subunit E 2 2
MIRT486866 DPF1 double PHD fingers 1 2 2
MIRT488343 PAX2 paired box 2 2 2
MIRT488790 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT490249 MFI2 melanotransferrin 2 2
MIRT490264 HAAO 3-hydroxyanthranilate 3,4-dioxygenase 2 2
MIRT490756 SRCIN1 SRC kinase signaling inhibitor 1 2 2
MIRT492321 SETD1B SET domain containing 1B 2 2
MIRT492851 NRGN neurogranin 2 2
MIRT499604 ANKRD45 ankyrin repeat domain 45 2 2
MIRT500189 BARX1 BARX homeobox 1 2 4
MIRT516765 FAM212B family with sequence similarity 212 member B 2 4
MIRT517949 TRIM59 tripartite motif containing 59 2 2
MIRT521182 SCAF4 SR-related CTD associated factor 4 2 2
MIRT526462 OSBPL5 oxysterol binding protein like 5 2 2
MIRT535148 PLEKHG5 pleckstrin homology and RhoGEF domain containing G5 2 2
MIRT569528 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 2
MIRT570593 NFIX nuclear factor I X 2 2
MIRT571219 F2R coagulation factor II thrombin receptor 2 2
MIRT574145 MARVELD1 MARVEL domain containing 1 2 2
MIRT608758 CACNA1A calcium voltage-gated channel subunit alpha1 A 2 2
MIRT649509 RAB17 RAB17, member RAS oncogene family 2 2
MIRT692165 RNF207 ring finger protein 207 2 2
MIRT703495 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT711081 NEUROD2 neuronal differentiation 2 2 2
MIRT712090 UNC13A unc-13 homolog A 2 2
MIRT712531 CYTH2 cytohesin 2 2 2
MIRT712755 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT712893 TGFA transforming growth factor alpha 2 2
MIRT714684 PRX periaxin 2 2
MIRT714723 VPS8 VPS8, CORVET complex subunit 2 2
MIRT714814 NOB1 NIN1/PSMD8 binding protein 1 homolog 2 2
MIRT716774 C1orf229 chromosome 1 open reading frame 229 2 2
MIRT717511 HRNR hornerin 2 2
MIRT717653 THBS2 thrombospondin 2 2 2
MIRT719595 PIAS4 protein inhibitor of activated STAT 4 2 2
MIRT720525 PTGR2 prostaglandin reductase 2 2 2
MIRT724925 VPS18 VPS18, CORVET/HOPS core subunit 2 2
MIRT737146 NOS3 nitric oxide synthase 3 1 0
MIRT756003 SLC7A5 solute carrier family 7 member 5 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-744 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-744 Tert-butyl hydroperoxide (t-BHP) NULL 6410 Microarray mouse auditory cells 20510889 2010 up-regulated
miR-744 Ursodeoxycholic acid (UDCA) approved 31401 Microarray rat Liver 20689055 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-744 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901)
hsa-mir-744 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-744 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-744 Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-mir-744 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-744 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-744 Cisplatin 5460033 NSC119875 approved resistant cell line (SGC-7901)
hsa-miR-744-5p [1,1'-binaphthalene]-2,2',3,3'-tetrol 316673 NSC245006 sensitive
hsa-miR-744-5p 4-n-[12-[(5-amino-6-chloropyrimidin-4-yl)amino]dodecyl]-6-chloropyrimidine-4,5-diamine 358989 NSC619196 sensitive
hsa-miR-744-5p 5,7-dibromo-2-[(e)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]quinolin-8-ol 135460261 NSC67090 sensitive
hsa-miR-744-5p Benzyl 2-(dibenzylamino)-3-phenylpropanoate 375616 NSC655438 sensitive
hsa-miR-744-5p N'-[(Z)-[(4Z)-2-(1,3-benzodioxol-5-yl)-4-[[4-oxo-4-[2-(trifluoromethyl)anilino]butanoyl]hydrazinylidene]chromen-3-ylidene]amino]-N-[2-(trifluoromethyl)phenyl]butanediamide 6399328 NSC641210 sensitive
hsa-miR-744-5p Paullone analog 47 396411 NSC702373 sensitive
hsa-miR-744-5p Ursa-11,13(18)-dien-28-oic acid-3.beta.-ol 378695 NSC661747 sensitive
hsa-miR-744-5p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7, LY2)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3)
hsa-miR-744-5p Carboplatin 38904 NSC241240 approved sensitive High Ovarian Cancer tissue and cell line (MDAH-2274, SKOV3)
hsa-miR-744-5p Gefitinib 123631 NSC715055 approved resistant High Lung Adenocarcinoma cell line (A549)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved sensitive High Esophageal Squamous Cell Carcinoma cell line (KYSE410)
hsa-miR-744-5p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-744-5p Vinorelbine 44424639 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-744-5p Epirubicin 41867 NSC256942 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-744-5p Erlotinib 176870 NSC718781 approved sensitive High Non-Small Cell Lung Cancer tissue
hsa-miR-744-5p Gefitinib 123631 NSC715055 approved sensitive High Non-Small Cell Lung Cancer tissue
hsa-miR-744-5p Sunitinib 5329102 NSC750690 approved sensitive High Renal Cell Cancer tissue
hsa-miR-744-5p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-744-5p Sorafenib 216239 NSC747971 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901, BGC-823)
hsa-miR-744-5p Oxaliplatin 6857599 NSC266046 approved resistant Low Colorectal Cancer cell line (HCT-116)
hsa-miR-744-5p Bortezomib 387447 NSC681239 approved sensitive Low Multiple Myeloma tissue
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-744-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-744-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-744-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-744-5p Fluorouracil 3385 NSC19893 approved sensitive cell line (HCT15)
hsa-miR-744-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-744-5p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-744-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-744-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-744-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-744-5p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-744-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-744-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-744-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-744-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-744-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (H23)

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