miRTarBase - #MIRT038021


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pre-miRNA Information
pre-miRNA hsa-mir-423   
Genomic Coordinates chr17: 30117079 - 30117172
Synonyms MIRN423, hsa-mir-423, MIR423
Description Homo sapiens miR-423 stem-loop
Comment miR-423 (renamed miR-423-3p here) is expressed in human promyelocytic leukemia (HL-60) cells .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-423-5p
Sequence 17| UGAGGGGCAGAGAGCGAGACUUU |39
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31534005 8 COSMIC
COSN31546484 21 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1237323143 1 dbSNP
rs766187585 6 dbSNP
rs901641664 10 dbSNP
rs776372668 14 dbSNP
rs1410439654 23 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BW9LU5 miR-423 Safety Biomarker (SAF) Clinical/Experimental Data Expression Higher Urine Quantitative polymerase chain reaction
BW9LU5 miR-423 Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Serum exosomes SRNA-sequencing
Gene Information
Gene Symbol IGDCC4   
Synonyms DDM36, NOPE
Description immunoglobulin superfamily DCC subclass member 4
Transcript NM_020962   
Expression
Putative miRNA Targets on IGDCC4
3'UTR of IGDCC4
(miRNA target sites are highlighted)		 
>IGDCC4|NM_020962|3'UTR
   1 CTCTTCCCAGAGGATGTGGTTTGGGGCAGGCAGGTATGGATCACATAGGATGCGATACCTGTGGCCGTGTATGTCCACAT
  81 GTGTGCCTGTAGATACATCATCAAGCCCTTTGGAGCTTCCTAAGTTGCTTTGGCTGAGGGGAGAGGAAAACATGGATTAT
 161 TCACTCCCCCCATACTCTTTGTGATACACATGTGACATGTGAAAGACATACGAGACATAGCTACATGTGATGTGCACATG
 241 TGTGAAGTGCATGTATGCGTACTGGTTGTTGAGCTGGGAAACCGTGGCCCAGGCAGTGGTCACTACAGCCTGATTGGTCC
 321 TCCAGGTCAGAACGGTGCCCCACAGTGGTCAGTCCCCAGCCCTGTGGGCCCCCACCTCCATCGCCCAGCCTTTTATTACA
 401 CACTCTGAGAGTGTCTCCAATGCCTGTCTGACAAAGACAGTCCCAGCCCATTCTCCTGTCTGGCTGGGTTGGGTGCAAGC
 481 AGGCTCTGAATGCCTGGCATTTCAGCTGCATCACCTCCCAGCTCCTTATTGCCCAAATAGAGAGGGTGGCCCTGGCTCCC
 561 CTCCGAGCAACTCTGCATTTAATTTTGTAATCTGGGAAGTGCCTGGTTTTGAAAATCCGCTTTCTCTCACTCTTCCCCTC
 641 CTTCCTTGCCCCTGGCTGCTCTAGTGTTCTGTCTCCCAGTCACCTCGCTCTCCCAGCACCAGTGCCCTTCTCCTGCTCCC
 721 AGATACTCTTTCCTTTCCTCTCTCCTGTTTTCCTTCCTCTGCTATCTCTCACACCTCTCCCAGACTATGTCATCTTGTTC
 801 TCCTGCCTGGGTTCAAACTCTGCATCCTTCTCTAACAACGTGACTACCTCATGTCTGCTTCAAGGCCCCCGTGCCCTTCC
 881 TGTATCCGCGGCTGCCGCGCACTCGCCTGCCATCCTCCTGCCTCCTCTTCACTCAGTGCTTCTGCTTGCCCTGCCCCAGG
 961 CAGCCCACCCACGCCCAGTGCGGGTGTGGAGAAGATCTTCTGGCTTCCCTGCATCTTGCCTTTGGGATTGGGATCCAAGG
1041 GTTCTCCATGGATGGATCCAAGTCATAGAGGGGAATGTTTGAGACAGGGAAGGGGGCTGTGATCCAGAGGCTCAGAATAA
1121 AAAGATGCCCTCCCTTCTATGCAGGGGGGCAAGTTTACTGGATGGAGATGATTTGGGCCTCTCTTCCAGAAGAAGCTAAA
1201 GGAAGAGAAGGGGAGTGAGAGTTCAGGGAGGCCCTTCCCACCCTGTGAGGCTTGACTTGATCTGGATTGGGGATGACAGG
1281 AATCTCACCCTCTGGGGTGCTGGCAAGGAGGTCTTTGCACAGGAAAAGGGGTAGCTCATTTCAGTTTGTTTTTTCTTTAA
1361 ATTGAATCCTCAAGTCATTTTCTGTTCACCTGCCGCACAGGGACAAGCTTGACTTCTATTTTCTGTGTAGTGAAAACAAT
1441 GTCATTTATTTGGTTTTTCACCTCAGCCCTCTCATAGGAGCATAGAATGTTAGGGTCTTTACTCCCTAATGATGTCTGAT
1521 TGGCACATCAAGAGTTAACTCTGCCTTCTGGGCCAAATTCGAAATAACCAGTCCATTTTTCCTTTTTTTTTTTTTTTTTT
1601 TTAAATGGTGGAATGTCTCTCAGCACAGTTGCGGCTTCCTCAAACCCTGAAAGCATCTGTGTTTATTATACTCGGGTGTC
1681 ACTCACTGTTGATGTCTGCACCTACGTTTCCACCTCCTCCCCCTCCTTCAGCCAGCCTATGATAACACTAAAGATTATTA
1761 ATGTTGGTTTTGTATCTCGTTAAAGACAGAATTGTCACTTGTAGTATTTCTGTAGCATTCAGCGCTGCTGTGGCTAACAC
1841 CACTGTGTATGTTTCATCATTGCTCTGAAGGTCAAAAGCCTCATTTTATTTTGCTGGTTTGATTTTTTTTTTTTAAAGAA
1921 GAAAAAAAAACTGCCCTGAATTAAATGGCTGTTTTAACAGTAGGCTCTTAGCATTATACCACATAGTCATTTTTCATGTT
2001 CTTGTTTAACAGGCACTGAGGTTCTGGTTTAAATTAAATAGCTGCAAATGAGACAATTTATAACCCATTAGGTTGGGTGG
2081 AAAATTGTTTCTCAAAAGCAAATAAGTAATAAATCTGGTATCTGCCTATAACTCACAGTTGATAAGAAAGTGGCCATTTC
2161 TCACTAGCACTATATATGATTTGGGCTCTGGGTAATTTGGAAGTGTTAGGTTTGTGTCTTTGTAGCAGTATTTTTATTAG
2241 AAAAGAATCTATTGGCCTTTTACAGGGTATTAATCCCTTTGTCACCTACCATTGATGCCTTAAGTTTTCTGAGTCTCAAT
2321 TAAAAATCTTCCTTTTCTTGATGCATGACAAGTGTAATCAGTACTTGCTCATTTATTTGTCTGTATTTAGTTTATGCTGT
2401 ACTATTTAATTATCCTTCCAGCGTTTTTTTTTTCTCCTTACAAATATGATACTCTTTAGTGTTAAGCTAAGGCATTGATT
2481 CATGTATCTGTCCTTATAATGAATTAATAAACTATTTTCCAG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuUCA---GAGCGAGAG----------ACGGGGAGu 5'
            |||   |||||||||          |||||:|| 
Target 5' ccAGTCACCTCGCTCTCCCAGCACCAGTGCCCTTCt 3'
 676 - 711 151.00 -26.10
2 
miRNA  3' uuucAGAGCGAGAGACGGGGAGu 5'
              |||| | |||| |||||| 
Target 5' gcttTCTCTCACTCTTCCCCTCc 3'
 619 - 641 147.00 -20.90
3 
miRNA  3' uuuCAGAG---CGAGAG-ACGGGGAGu 5'
             | :||   || | | |||||:|| 
Target 5' tctGCTTCAAGGCCCCCGTGCCCTTCc 3'
 854 - 880 136.00 -13.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31519476 11 COSMIC
COSN31558868 21 COSMIC
COSN31512330 22 COSMIC
COSN31560324 26 COSMIC
COSN26979684 54 COSMIC
COSN16199728 65 COSMIC
COSN1179050 132 COSMIC
COSN19438986 209 COSMIC
COSN15843479 354 COSMIC
COSN28198069 618 COSMIC
COSN29357443 666 COSMIC
COSN28710771 802 COSMIC
COSN31539491 827 COSMIC
COSN31514995 861 COSMIC
COSN15662040 1234 COSMIC
COSN25872396 1453 COSMIC
COSN26572662 1495 COSMIC
COSN31565668 1520 COSMIC
COSN31550113 1575 COSMIC
COSN26578790 1581 COSMIC
COSN18749779 1583 COSMIC
COSN20112184 1583 COSMIC
COSN26574589 1584 COSMIC
COSN31545875 1588 COSMIC
COSN31545719 1589 COSMIC
COSN24933548 1696 COSMIC
COSN31544567 1736 COSMIC
COSN8590255 1843 COSMIC
COSN27589479 1903 COSMIC
COSN31487575 1921 COSMIC
COSN31541022 1948 COSMIC
COSN31515382 2245 COSMIC
COSN23014842 2250 COSMIC
COSN20112178 2424 COSMIC
COSN15657848 2521 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs546179382 1 dbSNP
rs765907045 9 dbSNP
rs1418997003 10 dbSNP
rs1333964472 12 dbSNP
rs1330776385 14 dbSNP
rs1446949604 15 dbSNP
rs1393130805 16 dbSNP
rs1323268597 18 dbSNP
rs1462695721 19 dbSNP
rs1387081094 26 dbSNP
rs577397757 30 dbSNP
rs1164259350 31 dbSNP
rs1469945632 33 dbSNP
rs772971265 34 dbSNP
rs367727438 44 dbSNP
rs764767963 45 dbSNP
rs778812412 50 dbSNP
rs1211818589 51 dbSNP
rs913181284 53 dbSNP
rs1357507073 54 dbSNP
rs988661659 55 dbSNP
rs1266314693 57 dbSNP
rs1019176244 60 dbSNP
rs1351598669 62 dbSNP
rs1009120826 64 dbSNP
rs957054783 66 dbSNP
rs189570349 68 dbSNP
rs1332482349 71 dbSNP
rs1383681554 77 dbSNP
rs979886642 79 dbSNP
rs1458280375 90 dbSNP
rs1162422175 97 dbSNP
rs970248945 103 dbSNP
rs1449241829 107 dbSNP
rs1332254035 111 dbSNP
rs1024037836 116 dbSNP
rs1014198078 119 dbSNP
rs753943829 124 dbSNP
rs1444576607 130 dbSNP
rs1315438862 132 dbSNP
rs1025918244 134 dbSNP
rs186342912 138 dbSNP
rs1244589692 139 dbSNP
rs1264022638 140 dbSNP
rs777638624 144 dbSNP
rs1200175055 150 dbSNP
rs1472238223 153 dbSNP
rs1038805431 156 dbSNP
rs1006873526 163 dbSNP
rs1174970772 169 dbSNP
rs574565022 170 dbSNP
rs1424307530 172 dbSNP
rs1186629777 181 dbSNP
rs554547788 183 dbSNP
rs1051179291 184 dbSNP
rs1264435367 186 dbSNP
rs1216445894 187 dbSNP
rs755959390 191 dbSNP
rs933825619 198 dbSNP
rs1464193793 199 dbSNP
rs930590353 208 dbSNP
rs537808399 211 dbSNP
rs1228928003 212 dbSNP
rs913026061 226 dbSNP
rs1395926719 231 dbSNP
rs1355788539 240 dbSNP
rs1342791753 247 dbSNP
rs1052983147 251 dbSNP
rs1278521948 253 dbSNP
rs935890156 257 dbSNP
rs1201890260 258 dbSNP
rs752750635 259 dbSNP
rs1282628025 263 dbSNP
rs1483270123 268 dbSNP
rs925856729 271 dbSNP
rs980217874 276 dbSNP
rs1255240458 277 dbSNP
rs78283820 283 dbSNP
rs923569557 284 dbSNP
rs916995327 309 dbSNP
rs977789156 314 dbSNP
rs992552024 316 dbSNP
rs764682684 320 dbSNP
rs1178370376 325 dbSNP
rs552473027 327 dbSNP
rs960883940 333 dbSNP
rs968202660 334 dbSNP
rs1398017847 338 dbSNP
rs1301613017 341 dbSNP
rs1363002294 345 dbSNP
rs1401054374 346 dbSNP
rs1277939989 350 dbSNP
rs879453357 355 dbSNP
rs994324766 361 dbSNP
rs915023834 363 dbSNP
rs975295946 369 dbSNP
rs1312274882 370 dbSNP
rs1324173395 371 dbSNP
rs1404220740 375 dbSNP
rs1278187502 379 dbSNP
rs116139064 381 dbSNP
rs566673770 382 dbSNP
rs546448459 383 dbSNP
rs1424720131 389 dbSNP
rs889759021 390 dbSNP
rs180932476 396 dbSNP
rs573182725 412 dbSNP
rs998198990 439 dbSNP
rs1420812593 443 dbSNP
rs1223015874 451 dbSNP
rs1451102876 453 dbSNP
rs1287816679 455 dbSNP
rs1343828063 457 dbSNP
rs1438985529 480 dbSNP
rs1294925824 488 dbSNP
rs1367858874 501 dbSNP
rs891641740 514 dbSNP
rs1052910322 519 dbSNP
rs1385787831 524 dbSNP
rs1026730444 525 dbSNP
rs138064657 532 dbSNP
rs925898083 536 dbSNP
rs879399681 541 dbSNP
rs1277288921 548 dbSNP
rs1216536021 550 dbSNP
rs948394583 561 dbSNP
rs1285158878 564 dbSNP
rs765767037 565 dbSNP
rs116595224 567 dbSNP
rs1435757108 570 dbSNP
rs1347546909 572 dbSNP
rs993001285 576 dbSNP
rs1488267419 586 dbSNP
rs929070073 587 dbSNP
rs918991244 589 dbSNP
rs1398088610 592 dbSNP
rs1440344229 595 dbSNP
rs972936096 607 dbSNP
rs1158594051 614 dbSNP
rs762670950 618 dbSNP
rs78108291 619 dbSNP
rs1165909093 620 dbSNP
rs1168152565 621 dbSNP
rs985689981 623 dbSNP
rs1464376958 638 dbSNP
rs1427775802 639 dbSNP
rs772678942 655 dbSNP
rs894952701 660 dbSNP
rs1378501076 674 dbSNP
rs1446803737 676 dbSNP
rs116445399 677 dbSNP
rs879651157 681 dbSNP
rs1229871601 685 dbSNP
rs1290291321 686 dbSNP
rs998125859 687 dbSNP
rs1212083203 694 dbSNP
rs891902877 697 dbSNP
rs923895246 700 dbSNP
rs1042441384 702 dbSNP
rs1178090581 705 dbSNP
rs1231729428 708 dbSNP
rs1474045390 715 dbSNP
rs1031711214 721 dbSNP
rs1257638613 736 dbSNP
rs188131684 740 dbSNP
rs1162364904 748 dbSNP
rs761021456 749 dbSNP
rs1401941968 750 dbSNP
rs1465742832 752 dbSNP
rs756623204 756 dbSNP
rs776013541 758 dbSNP
rs142472543 765 dbSNP
rs1044725877 767 dbSNP
rs1284661912 774 dbSNP
rs1354598849 779 dbSNP
rs1218520107 795 dbSNP
rs1365438138 800 dbSNP
rs1310765215 806 dbSNP
rs551345586 808 dbSNP
rs1280411521 809 dbSNP
rs895709375 812 dbSNP
rs774498557 818 dbSNP
rs540382331 820 dbSNP
rs928953871 821 dbSNP
rs574603077 823 dbSNP
rs964436982 829 dbSNP
rs973115303 833 dbSNP
rs1270928648 836 dbSNP
rs1444161438 837 dbSNP
rs1361203156 839 dbSNP
rs912020266 840 dbSNP
rs554684725 845 dbSNP
rs370951747 847 dbSNP
rs1474433651 850 dbSNP
rs544278629 852 dbSNP
rs941527735 853 dbSNP
rs1196284623 864 dbSNP
rs910026420 866 dbSNP
rs986128032 870 dbSNP
rs575628252 872 dbSNP
rs1414361793 875 dbSNP
rs1026595871 879 dbSNP
rs1416803248 887 dbSNP
rs770862778 888 dbSNP
rs1030306939 889 dbSNP
rs1374772137 890 dbSNP
rs184897777 896 dbSNP
rs1299782617 897 dbSNP
rs558644242 898 dbSNP
rs1227004603 899 dbSNP
rs562935208 901 dbSNP
rs1023402131 902 dbSNP
rs538944538 904 dbSNP
rs1176933201 905 dbSNP
rs1000214909 917 dbSNP
rs1264388159 922 dbSNP
rs1056309402 924 dbSNP
rs1003412614 929 dbSNP
rs902408853 935 dbSNP
rs904369045 945 dbSNP
rs1042281783 946 dbSNP
rs1172647299 948 dbSNP
rs1394451111 949 dbSNP
rs946636739 950 dbSNP
rs1022826889 955 dbSNP
rs749583762 966 dbSNP
rs1360952840 973 dbSNP
rs566600562 977 dbSNP
rs35640355 978 dbSNP
rs943118989 978 dbSNP
rs553139264 979 dbSNP
rs1437341997 980 dbSNP
rs1302726124 981 dbSNP
rs1345767406 982 dbSNP
rs147688425 984 dbSNP
rs112013434 990 dbSNP
rs1350419562 994 dbSNP
rs1203754240 1003 dbSNP
rs897455253 1011 dbSNP
rs1352249031 1013 dbSNP
rs1259306272 1019 dbSNP
rs1452948341 1025 dbSNP
rs1198998200 1026 dbSNP
rs1306470455 1028 dbSNP
rs1037473041 1038 dbSNP
rs550725805 1040 dbSNP
rs530608258 1049 dbSNP
rs868522327 1056 dbSNP
rs140442930 1062 dbSNP
rs1325417474 1073 dbSNP
rs1049947490 1077 dbSNP
rs1301936324 1079 dbSNP
rs568294244 1081 dbSNP
rs1368891742 1082 dbSNP
rs1449007211 1086 dbSNP
rs1357847390 1093 dbSNP
rs375795091 1093 dbSNP
rs932808193 1095 dbSNP
rs2607876 1096 dbSNP
rs386784833 1097 dbSNP
rs1425271799 1098 dbSNP
rs566654055 1098 dbSNP
rs532845059 1103 dbSNP
rs1357443866 1104 dbSNP
rs1379710271 1110 dbSNP
rs751386626 1115 dbSNP
rs956060482 1125 dbSNP
rs560582977 1139 dbSNP
rs530119276 1144 dbSNP
rs1414767657 1149 dbSNP
rs75450422 1150 dbSNP
rs1251229771 1151 dbSNP
rs1418400161 1159 dbSNP
rs1181553372 1163 dbSNP
rs1482148660 1169 dbSNP
rs1370001875 1175 dbSNP
rs112860742 1181 dbSNP
rs960106490 1186 dbSNP
rs1187083591 1187 dbSNP
rs968854939 1194 dbSNP
rs1332094727 1203 dbSNP
rs757828570 1213 dbSNP
rs1023469221 1214 dbSNP
rs1390203419 1218 dbSNP
rs1315384116 1224 dbSNP
rs750152759 1232 dbSNP
rs112120191 1240 dbSNP
rs1292368065 1250 dbSNP
rs1332203912 1256 dbSNP
rs998955663 1264 dbSNP
rs1251416216 1267 dbSNP
rs960109213 1268 dbSNP
rs902313576 1273 dbSNP
rs1035609736 1276 dbSNP
rs993389989 1284 dbSNP
rs1246314132 1295 dbSNP
rs1321847728 1296 dbSNP
rs1258099023 1310 dbSNP
rs1311553942 1312 dbSNP
rs761409310 1321 dbSNP
rs1186939117 1328 dbSNP
rs775867959 1334 dbSNP
rs1416016856 1339 dbSNP
rs1478905162 1351 dbSNP
rs1037399063 1361 dbSNP
rs1171606837 1368 dbSNP
rs767807142 1370 dbSNP
rs1010782990 1372 dbSNP
rs1460481637 1376 dbSNP
rs1305119918 1378 dbSNP
rs537833847 1381 dbSNP
rs114833184 1384 dbSNP
rs888907622 1387 dbSNP
rs1353884086 1389 dbSNP
rs1050567138 1390 dbSNP
rs192798722 1394 dbSNP
rs943066668 1395 dbSNP
rs890184626 1400 dbSNP
rs1224605853 1403 dbSNP
rs575620770 1419 dbSNP
rs922752137 1434 dbSNP
rs1051437621 1435 dbSNP
rs1041296332 1439 dbSNP
rs779996915 1453 dbSNP
rs1360489975 1459 dbSNP
rs934943533 1462 dbSNP
rs558912688 1467 dbSNP
rs924848488 1469 dbSNP
rs1459460295 1470 dbSNP
rs929070742 1472 dbSNP
rs1426886474 1476 dbSNP
rs1178311295 1483 dbSNP
rs1396262261 1484 dbSNP
rs1350548179 1485 dbSNP
rs1164344712 1488 dbSNP
rs1434608759 1488 dbSNP
rs978824911 1489 dbSNP
rs1422348310 1491 dbSNP
rs1400920068 1502 dbSNP
rs1425480812 1507 dbSNP
rs749299073 1514 dbSNP
rs919400142 1518 dbSNP
rs1302720099 1524 dbSNP
rs1194169878 1526 dbSNP
rs916006057 1527 dbSNP
rs1477391791 1539 dbSNP
rs1355593874 1540 dbSNP
rs33998478 1548 dbSNP
rs148776639 1552 dbSNP
rs573178952 1558 dbSNP
rs189817848 1560 dbSNP
rs536531267 1561 dbSNP
rs1035493409 1562 dbSNP
rs567506121 1564 dbSNP
rs966270985 1565 dbSNP
rs991477084 1566 dbSNP
rs960054670 1570 dbSNP
rs557161087 1571 dbSNP
rs1280453873 1573 dbSNP
rs1035704911 1574 dbSNP
rs1167975644 1575 dbSNP
rs200155564 1581 dbSNP
rs1340316182 1582 dbSNP
rs1293979839 1583 dbSNP
rs977468228 1588 dbSNP
rs993316135 1590 dbSNP
rs1368383501 1591 dbSNP
rs1371114566 1594 dbSNP
rs1439439640 1597 dbSNP
rs879159190 1599 dbSNP
rs1460045053 1601 dbSNP
rs961977191 1602 dbSNP
rs1020783303 1603 dbSNP
rs1195929430 1603 dbSNP
rs1224065854 1603 dbSNP
rs1240623048 1603 dbSNP
rs1470779153 1603 dbSNP
rs754941677 1603 dbSNP
rs967867526 1603 dbSNP
rs1011188884 1604 dbSNP
rs1425869228 1607 dbSNP
rs79447611 1609 dbSNP
rs77762159 1610 dbSNP
rs1464856625 1615 dbSNP
rs1323287038 1616 dbSNP
rs1421213605 1617 dbSNP
rs1016183606 1620 dbSNP
rs893710047 1621 dbSNP
rs1442876711 1622 dbSNP
rs1017498644 1631 dbSNP
rs1370913724 1631 dbSNP
rs1229815744 1632 dbSNP
rs1007450298 1641 dbSNP
rs1334410333 1660 dbSNP
rs1266025383 1673 dbSNP
rs1005917185 1674 dbSNP
rs1438416863 1679 dbSNP
rs1204461288 1683 dbSNP
rs890092643 1689 dbSNP
rs1189082660 1693 dbSNP
rs888742643 1699 dbSNP
rs1458735275 1702 dbSNP
rs1258244452 1703 dbSNP
rs1050204647 1705 dbSNP
rs1474659541 1706 dbSNP
rs1051386543 1710 dbSNP
rs1421052976 1711 dbSNP
rs3169063 1713 dbSNP
rs537167190 1722 dbSNP
rs773618996 1723 dbSNP
rs1250039341 1724 dbSNP
rs879031819 1735 dbSNP
rs934828846 1739 dbSNP
rs1313225047 1746 dbSNP
rs1354539098 1748 dbSNP
rs903480081 1750 dbSNP
rs1236044958 1756 dbSNP
rs1249204574 1757 dbSNP
rs942223659 1761 dbSNP
rs1043667490 1767 dbSNP
rs1272084980 1770 dbSNP
rs1313340224 1772 dbSNP
rs1340163926 1778 dbSNP
rs1214062847 1779 dbSNP
rs947411096 1794 dbSNP
rs1212097186 1808 dbSNP
rs769739073 1811 dbSNP
rs1301225823 1823 dbSNP
rs76009112 1824 dbSNP
rs1243484503 1827 dbSNP
rs551366641 1828 dbSNP
rs1056026592 1830 dbSNP
rs938920617 1835 dbSNP
rs1436535582 1850 dbSNP
rs146112158 1858 dbSNP
rs1374637666 1878 dbSNP
rs977458310 1881 dbSNP
rs928684038 1882 dbSNP
rs1327237621 1885 dbSNP
rs1430167433 1894 dbSNP
rs971929503 1896 dbSNP
rs1466455350 1901 dbSNP
rs914670016 1904 dbSNP
rs1235699274 1907 dbSNP
rs1280174087 1911 dbSNP
rs1346248287 1912 dbSNP
rs555753230 1914 dbSNP
rs1017404411 1915 dbSNP
rs1194188314 1915 dbSNP
rs1322658450 1915 dbSNP
rs958086786 1915 dbSNP
rs1394402477 1916 dbSNP
rs1171705261 1918 dbSNP
rs1440934785 1921 dbSNP
rs1016187772 1923 dbSNP
rs985092053 1928 dbSNP
rs1029952442 1931 dbSNP
rs3830551 1931 dbSNP
rs539626541 1931 dbSNP
rs1396802848 1944 dbSNP
rs770160889 1946 dbSNP
rs953087976 1948 dbSNP
rs993605159 1954 dbSNP
rs1029106334 1958 dbSNP
rs897561766 1961 dbSNP
rs1241674330 1966 dbSNP
rs748339204 1967 dbSNP
rs901640705 1969 dbSNP
rs1204195138 1971 dbSNP
rs1265775416 1980 dbSNP
rs1469475307 1981 dbSNP
rs1213761538 1988 dbSNP
rs1252355338 1992 dbSNP
rs1452469732 1993 dbSNP
rs1005990767 1994 dbSNP
rs1183854419 1998 dbSNP
rs894612510 2001 dbSNP
rs1055974465 2004 dbSNP
rs1030700572 2014 dbSNP
rs1202506480 2020 dbSNP
rs1462077919 2034 dbSNP
rs1483797342 2039 dbSNP
rs781137808 2042 dbSNP
rs373173790 2044 dbSNP
rs144383449 2046 dbSNP
rs1330070907 2050 dbSNP
rs1237325956 2052 dbSNP
rs1286138150 2055 dbSNP
rs903321759 2056 dbSNP
rs938910706 2057 dbSNP
rs1272027401 2061 dbSNP
rs754671479 2064 dbSNP
rs1197501437 2065 dbSNP
rs758249675 2068 dbSNP
rs1251070455 2069 dbSNP
rs1437086673 2094 dbSNP
rs947597247 2099 dbSNP
rs1179722700 2111 dbSNP
rs747021701 2115 dbSNP
rs1056221673 2117 dbSNP
rs938660354 2119 dbSNP
rs1415782028 2120 dbSNP
rs1041705084 2124 dbSNP
rs1463528008 2128 dbSNP
rs1169063261 2129 dbSNP
rs1396395087 2141 dbSNP
rs530295627 2145 dbSNP
rs1315145337 2157 dbSNP
rs928736359 2162 dbSNP
rs1415044177 2163 dbSNP
rs2280345 2170 dbSNP
rs940525511 2172 dbSNP
rs370921784 2183 dbSNP
rs879107674 2191 dbSNP
rs1228969783 2201 dbSNP
rs878871494 2208 dbSNP
rs984629815 2214 dbSNP
rs1251866669 2216 dbSNP
rs953443418 2218 dbSNP
rs1338630544 2222 dbSNP
rs990610494 2223 dbSNP
rs1028908021 2228 dbSNP
rs544352192 2245 dbSNP
rs975755887 2246 dbSNP
rs1259381691 2247 dbSNP
rs965650076 2249 dbSNP
rs1336432783 2250 dbSNP
rs1030711851 2251 dbSNP
rs1396342933 2252 dbSNP
rs1430434058 2255 dbSNP
rs964169658 2256 dbSNP
rs1373051061 2264 dbSNP
rs531041948 2266 dbSNP
rs1401246192 2268 dbSNP
rs1176028261 2281 dbSNP
rs1376460310 2286 dbSNP
rs999207474 2289 dbSNP
rs903363758 2300 dbSNP
rs776468868 2302 dbSNP
rs757963677 2311 dbSNP
rs185316057 2320 dbSNP
rs954621615 2327 dbSNP
rs894756840 2328 dbSNP
rs1226101479 2334 dbSNP
rs1282291765 2336 dbSNP
rs375244566 2338 dbSNP
rs1002880624 2348 dbSNP
rs1209869762 2358 dbSNP
rs1157572243 2367 dbSNP
rs907181184 2368 dbSNP
rs961993122 2370 dbSNP
rs1036463500 2374 dbSNP
rs1261159728 2381 dbSNP
rs940784860 2382 dbSNP
rs1015936120 2415 dbSNP
rs545477800 2422 dbSNP
rs1454155210 2423 dbSNP
rs1347276366 2424 dbSNP
rs1369790496 2424 dbSNP
rs1187832678 2426 dbSNP
rs909282596 2427 dbSNP
rs371231890 2429 dbSNP
rs1289027381 2434 dbSNP
rs1432253389 2434 dbSNP
rs398078267 2434 dbSNP
rs5813350 2434 dbSNP
rs5813351 2434 dbSNP
rs869289458 2434 dbSNP
rs1257339178 2436 dbSNP
rs1209336539 2437 dbSNP
rs1489584078 2438 dbSNP
rs1049407016 2441 dbSNP
rs1286786260 2441 dbSNP
rs573182439 2443 dbSNP
rs559770672 2445 dbSNP
rs1348653822 2448 dbSNP
rs749910008 2451 dbSNP
rs894265809 2452 dbSNP
rs1034516020 2454 dbSNP
rs1298967922 2474 dbSNP
rs931827550 2482 dbSNP
rs1318458643 2484 dbSNP
rs1286112686 2486 dbSNP
rs542961915 2492 dbSNP
rs907441430 2494 dbSNP
rs1215623461 2497 dbSNP
rs1254234801 2499 dbSNP
rs1339644205 2516 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site CDS
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuucagagcgagagacGGGGAgu 5'
                          |||||  
Target 5' -----------gaccaCCCCTgc 3'
 		1 - 12
2 
miRNA  3' uuucaGAGCGAGAGACGGG-G-AGU------- 5'
               ||  ||| | |||| | ||        
Target 5' cacccCTGCCTC-CAGCCCACGTCCATGCGGA 3'
 		4 - 34
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21687 Ependynoma primary tumors 0.325 4.4e-3 0.220 4.0e-2 64 Click to see details
GSE42095 Differentiated embryonic stem cells -0.399 3.0e-2 -0.378 3.8e-2 23 Click to see details
GSE19783 ER- ER- breast cancer -0.145 1.0e-1 -0.113 1.6e-1 79 Click to see details
GSE28260 Renal cortex and medulla -0.342 1.3e-1 -0.115 3.5e-1 13 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.396 1.5e-1 -0.567 5.6e-2 9 Click to see details
GSE21032 Prostate cancer 0.108 1.7e-1 0.165 6.8e-2 83 Click to see details
GSE26953 Aortic valvular endothelial cells -0.184 1.9e-1 -0.142 2.5e-1 24 Click to see details
GSE28544 Breast cancer 0.147 2.5e-1 0.255 1.1e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.134 2.9e-1 -0.334 7.5e-2 20 Click to see details
GSE19783 ER+ ER+ breast cancer -0.126 3.0e-1 -0.144 2.7e-1 20 Click to see details
GSE19350 CNS germ cell tumors 0.114 3.6e-1 0.175 2.9e-1 12 Click to see details
GSE19536 Breast cancer -0.031 3.8e-1 -0.028 3.9e-1 100 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.064 3.8e-1 0.164 2.2e-1 25 Click to see details
GSE32688 Pancreatic cancer -0.045 4.0e-1 0.058 3.8e-1 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.016 4.7e-1 -0.125 2.8e-1 25 Click to see details
GSE38226 Liver fibrosis -0.012 4.8e-1 -0.104 3.3e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA -0.225 0.02 -0.135 0.11 84 Click to see details
COAD -0.699 0.03 -0.690 0.03 8 Click to see details
UCEC 0.432 0.03 0.518 0.01 19 Click to see details
CESC 0.991 0.04 1.000 0.5 3 Click to see details
CHOL -0.509 0.08 -0.517 0.08 9 Click to see details
KICH -0.262 0.1 -0.295 0.08 25 Click to see details
PRAD -0.182 0.1 -0.153 0.14 50 Click to see details
KIRC -0.143 0.12 -0.080 0.26 68 Click to see details
THCA 0.149 0.13 0.113 0.2 59 Click to see details
LIHC 0.161 0.13 0.131 0.18 49 Click to see details
PAAD -0.635 0.18 -0.800 0.1 4 Click to see details
LUAD 0.276 0.19 0.168 0.3 12 Click to see details
LUSC -0.144 0.19 -0.123 0.23 38 Click to see details
BLCA 0.138 0.29 0.193 0.22 18 Click to see details
ESCA 0.153 0.33 0.027 0.47 11 Click to see details
KIRP 0.075 0.34 0.097 0.3 32 Click to see details
HNSC 0.052 0.37 0.080 0.31 42 Click to see details
STAD 0.056 0.38 0.065 0.36 32 Click to see details
PCPG -0.043 0.49 -0.500 0.33 3 Click to see details
PCPG -0.043 0.49 -0.500 0.33 3 Click to see details
PCPG -0.043 0.49 -0.500 0.33 3 Click to see details
300 hsa-miR-423-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038011 RABAC1 Rab acceptor 1 1 1
MIRT038012 NMD3 NMD3 ribosome export adaptor 1 1
MIRT038013 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 1 1
MIRT038014 RGPD2 RANBP2-like and GRIP domain containing 2 1 1
MIRT038015 TSPYL6 TSPY like 6 1 1
MIRT038016 HIST2H2BE histone cluster 2 H2B family member e 1 1
MIRT038017 USP6 ubiquitin specific peptidase 6 1 1
MIRT038018 PGAM4 phosphoglycerate mutase family member 4 2 3
MIRT038019 DIP2A disco interacting protein 2 homolog A 1 1
MIRT038020 NOS1AP nitric oxide synthase 1 adaptor protein 2 3
MIRT038021 IGDCC4 immunoglobulin superfamily DCC subclass member 4 1 1
MIRT038022 RC3H1 ring finger and CCCH-type domains 1 1 1
MIRT038023 KIF1A kinesin family member 1A 1 1
MIRT038024 SRSF11 serine and arginine rich splicing factor 11 1 1
MIRT038025 BCLAF1 BCL2 associated transcription factor 1 1 1
MIRT038026 RPS15A ribosomal protein S15a 1 1
MIRT038027 CCNI cyclin I 1 1
MIRT038028 GDF11 growth differentiation factor 11 1 1
MIRT038029 FAM127A retrotransposon Gag like 8C 1 1
MIRT038030 NME2 NME/NM23 nucleoside diphosphate kinase 2 1 1
MIRT038031 COX1 cytochrome c oxidase subunit I 1 1
MIRT038032 ARPC1A actin related protein 2/3 complex subunit 1A 1 1
MIRT038033 MYBL2 MYB proto-oncogene like 2 1 1
MIRT038034 ND5 NADH dehydrogenase, subunit 5 (complex I) 1 1
MIRT038035 NDE1 nudE neurodevelopment protein 1 1 1
MIRT038036 CDKN2A cyclin dependent kinase inhibitor 2A 1 1
MIRT038037 TDRKH tudor and KH domain containing 1 1
MIRT038038 AKAP13 A-kinase anchoring protein 13 1 1
MIRT038039 RPS10 ribosomal protein S10 1 1
MIRT038040 PRPF38B pre-mRNA processing factor 38B 1 1
MIRT038041 PPIAL4G peptidylprolyl isomerase A like 4G 1 1
MIRT038042 MRPL34 mitochondrial ribosomal protein L34 1 1
MIRT038043 NDRG1 N-myc downstream regulated 1 1 1
MIRT038044 ZBTB34 zinc finger and BTB domain containing 34 1 1
MIRT038045 ATP6 ATP synthase F0 subunit 6 1 1
MIRT038046 ZFP36L1 ZFP36 ring finger protein like 1 1 1
MIRT038047 COQ6 coenzyme Q6, monooxygenase 1 1
MIRT038048 EPM2AIP1 EPM2A interacting protein 1 1 1
MIRT038049 REPS1 RALBP1 associated Eps domain containing 1 1 1
MIRT038050 AAR2 AAR2 splicing factor homolog 1 1
MIRT038051 PPIA peptidylprolyl isomerase A 1 1
MIRT038052 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 7
MIRT038053 DDX21 DExD-box helicase 21 1 1
MIRT038054 SLC6A6 solute carrier family 6 member 6 1 1
MIRT038055 RPS2 ribosomal protein S2 1 1
MIRT038056 CSTB cystatin B 1 1
MIRT038057 ABCC5 ATP binding cassette subfamily C member 5 2 5
MIRT038058 PAK1 p21 (RAC1) activated kinase 1 1 1
MIRT038059 ERRFI1 ERBB receptor feedback inhibitor 1 1 1
MIRT038060 CEACAM6 carcinoembryonic antigen related cell adhesion molecule 6 1 1
MIRT038061 FHOD1 formin homology 2 domain containing 1 1 1
MIRT038062 LMNB2 lamin B2 1 1
MIRT038063 NECAP1 NECAP endocytosis associated 1 1 1
MIRT038064 NPLOC4 NPL4 homolog, ubiquitin recognition factor 1 1
MIRT038065 PMPCA peptidase, mitochondrial processing alpha subunit 1 1
MIRT038066 C12orf10 chromosome 12 open reading frame 10 1 1
MIRT038067 DDX54 DEAD-box helicase 54 1 1
MIRT038068 VAC14 Vac14, PIKFYVE complex component 1 1
MIRT038069 RUNX1 runt related transcription factor 1 1 1
MIRT038070 FAM98A family with sequence similarity 98 member A 1 1
MIRT038071 EPN1 epsin 1 1 1
MIRT038072 TMUB1 transmembrane and ubiquitin like domain containing 1 1 1
MIRT038073 UBE2L3 ubiquitin conjugating enzyme E2 L3 1 1
MIRT038074 FAM110B family with sequence similarity 110 member B 1 1
MIRT038075 MICALL1 MICAL like 1 1 1
MIRT038076 PNRC1 proline rich nuclear receptor coactivator 1 1 1
MIRT038077 DLX5 distal-less homeobox 5 1 1
MIRT038078 ZNF655 zinc finger protein 655 1 1
MIRT038079 FAAH fatty acid amide hydrolase 1 1
MIRT038080 ATN1 atrophin 1 1 1
MIRT038081 ATP6V1E1 ATPase H+ transporting V1 subunit E1 1 1
MIRT038082 SLC9A3R1 SLC9A3 regulator 1 1 1
MIRT038083 NOLC1 nucleolar and coiled-body phosphoprotein 1 1 1
MIRT038084 PLCB1 phospholipase C beta 1 5 1
MIRT038085 SQSTM1 sequestosome 1 1 1
MIRT038086 CLSTN1 calsyntenin 1 1 1
MIRT038087 ULK1 unc-51 like autophagy activating kinase 1 1 1
MIRT038088 ATP2B4 ATPase plasma membrane Ca2+ transporting 4 1 1
MIRT038089 EPB41 erythrocyte membrane protein band 4.1 1 1
MIRT038090 HIST1H1C histone cluster 1 H1 family member c 1 1
MIRT038091 AGPAT6 glycerol-3-phosphate acyltransferase 4 1 1
MIRT038092 TPGS2 tubulin polyglutamylase complex subunit 2 1 1
MIRT038093 FKBP4 FK506 binding protein 4 1 1
MIRT038094 GNG12 G protein subunit gamma 12 1 1
MIRT038095 RPS9 ribosomal protein S9 1 1
MIRT038096 RPL18A ribosomal protein L18a 1 1
MIRT038097 CCND2 cyclin D2 1 1
MIRT038098 PCBP1 poly(rC) binding protein 1 1 1
MIRT038099 AP3M1 adaptor related protein complex 3 mu 1 subunit 1 1
MIRT038100 PDPK1 3-phosphoinositide dependent protein kinase 1 4 2
MIRT038101 WBP2 WW domain binding protein 2 1 1
MIRT038102 CLSPN claspin 1 1
MIRT038103 PTTG1 pituitary tumor-transforming 1 1 1
MIRT038104 GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 1 1
MIRT038105 GAPDH glyceraldehyde-3-phosphate dehydrogenase 1 1
MIRT038106 ARHGDIA Rho GDP dissociation inhibitor alpha 1 1
MIRT038107 KCTD2 potassium channel tetramerization domain containing 2 1 1
MIRT038108 RNF139 ring finger protein 139 1 1
MIRT038109 ARHGAP32 Rho GTPase activating protein 32 1 1
MIRT038110 HIST1H2BK histone cluster 1 H2B family member k 1 1
MIRT038111 SAR1B secretion associated Ras related GTPase 1B 1 1
MIRT038112 PA2G4 proliferation-associated 2G4 1 1
MIRT038113 UBE2D3 ubiquitin conjugating enzyme E2 D3 1 1
MIRT038114 GTPBP1 GTP binding protein 1 1 1
MIRT038115 HIST2H2BF histone cluster 2 H2B family member f 1 1
MIRT038116 NUTM1 NUT midline carcinoma family member 1 1 1
MIRT038117 COPS7A COP9 signalosome subunit 7A 1 1
MIRT038118 POLR3H RNA polymerase III subunit H 1 1
MIRT038119 HIST1H1E histone cluster 1 H1 family member e 1 1
MIRT038120 NFKB2 nuclear factor kappa B subunit 2 1 1
MIRT038121 SLC7A2 solute carrier family 7 member 2 1 1
MIRT038122 TIMP3 TIMP metallopeptidase inhibitor 3 1 1
MIRT038123 PTMA prothymosin, alpha 1 1
MIRT038124 CSDE1 cold shock domain containing E1 1 1
MIRT038125 CD81 CD81 molecule 1 1
MIRT038126 CCNF cyclin F 1 1
MIRT038127 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 1 1
MIRT038128 RCE1 Ras converting CAAX endopeptidase 1 1 1
MIRT038129 FAM83H family with sequence similarity 83 member H 1 1
MIRT038130 HES4 hes family bHLH transcription factor 4 1 1
MIRT038131 FAM189B family with sequence similarity 189 member B 2 3
MIRT038132 SLC48A1 solute carrier family 48 member 1 1 1
MIRT038133 SNX8 sorting nexin 8 1 1
MIRT038134 ZYX zyxin 1 1
MIRT038135 DRAP1 DR1 associated protein 1 1 1
MIRT038136 TEX2 testis expressed 2 1 1
MIRT038137 C15orf39 chromosome 15 open reading frame 39 1 1
MIRT038138 LRCH4 leucine rich repeats and calponin homology domain containing 4 1 1
MIRT038139 CHD8 chromodomain helicase DNA binding protein 8 1 1
MIRT038140 MYC MYC proto-oncogene, bHLH transcription factor 1 1
MIRT038141 TRIM28 tripartite motif containing 28 1 1
MIRT038142 SEPN1 selenoprotein N 1 1
MIRT038143 MIER2 MIER family member 2 1 1
MIRT038144 HOXA7 homeobox A7 1 1
MIRT038145 PRRC2A proline rich coiled-coil 2A 1 1
MIRT038146 SRP54 signal recognition particle 54 1 1
MIRT038147 PABPC1 poly(A) binding protein cytoplasmic 1 1 1
MIRT038148 SRM spermidine synthase 2 7
MIRT038149 GTF2F1 general transcription factor IIF subunit 1 1 1
MIRT038150 HIPK2 homeodomain interacting protein kinase 2 1 1
MIRT038151 NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 1 1
MIRT038152 COPZ1 coatomer protein complex subunit zeta 1 1 1
MIRT038153 GLUL glutamate-ammonia ligase 1 1
MIRT038154 PPARGC1B PPARG coactivator 1 beta 1 1
MIRT038155 PKM pyruvate kinase, muscle 1 1
MIRT038156 MTCH2 mitochondrial carrier 2 1 1
MIRT038157 ACTG1 actin gamma 1 1 1
MIRT038158 MTMR3 myotubularin related protein 3 1 1
MIRT038159 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 1 1
MIRT038160 DDX24 DEAD-box helicase 24 1 1
MIRT038161 TUBB tubulin beta class I 1 1
MIRT038162 NSD1 nuclear receptor binding SET domain protein 1 2 3
MIRT038163 PAX2 paired box 2 2 3
MIRT038164 ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 1 1
MIRT038165 CEBPB CCAAT/enhancer binding protein beta 1 1
MIRT038166 YARS tyrosyl-tRNA synthetase 1 1
MIRT038167 STRIP2 striatin interacting protein 2 1 1
MIRT038168 KCTD15 potassium channel tetramerization domain containing 15 1 1
MIRT038169 RPL23A ribosomal protein L23a 1 1
MIRT038170 MFGE8 milk fat globule-EGF factor 8 protein 1 1
MIRT038171 SF3B3 splicing factor 3b subunit 3 2 5
MIRT038172 RPL10 ribosomal protein L10 1 1
MIRT038173 SALL1 spalt like transcription factor 1 1 1
MIRT038174 BCCIP BRCA2 and CDKN1A interacting protein 1 1
MIRT038175 PSMD6 proteasome 26S subunit, non-ATPase 6 1 1
MIRT038176 MED28 mediator complex subunit 28 2 3
MIRT038177 MESDC1 talin rod domain containing 1 1 1
MIRT038178 DAG1 dystroglycan 1 1 1
MIRT053601 TFF1 trefoil factor 1 3 1
MIRT060312 RPS6KA4 ribosomal protein S6 kinase A4 2 2
MIRT113259 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 2
MIRT246175 TXNIP thioredoxin interacting protein 2 6
MIRT253003 CALM3 calmodulin 3 2 2
MIRT254645 NF2 neurofibromin 2 2 2
MIRT283307 UBFD1 ubiquitin family domain containing 1 2 4
MIRT348822 U2AF2 U2 small nuclear RNA auxiliary factor 2 2 2
MIRT369280 ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein like 2 2 2
MIRT448590 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT449933 TPST2 tyrosylprotein sulfotransferase 2 2 2
MIRT451072 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT451722 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT451796 TLR5 toll like receptor 5 2 2
MIRT454761 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2 2
MIRT454905 SEPT8 septin 8 2 17
MIRT455511 C6orf106 chromosome 6 open reading frame 106 2 2
MIRT455534 GJB1 gap junction protein beta 1 2 2
MIRT456322 ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 2 2
MIRT456420 MTRF1L mitochondrial translational release factor 1 like 2 2
MIRT456577 NID1 nidogen 1 2 2
MIRT457530 ZMAT5 zinc finger matrin-type 5 2 2
MIRT458422 KLHL38 kelch like family member 38 2 6
MIRT459072 WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 2 2
MIRT459510 TACR3 tachykinin receptor 3 2 2
MIRT460957 MUL1 mitochondrial E3 ubiquitin protein ligase 1 2 2
MIRT462614 C20orf27 chromosome 20 open reading frame 27 2 2
MIRT463958 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT464328 UST uronyl 2-sulfotransferase 2 2
MIRT464375 URM1 ubiquitin related modifier 1 2 2
MIRT466752 SYNGR2 synaptogyrin 2 2 2
MIRT467206 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT467294 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT467370 SP1 Sp1 transcription factor 2 2
MIRT468366 SETD8 lysine methyltransferase 5A 2 2
MIRT470189 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT470469 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT470813 PLXND1 plexin D1 2 2
MIRT471415 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472958 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT473207 MINK1 misshapen like kinase 1 2 4
MIRT473434 MDM4 MDM4, p53 regulator 2 2
MIRT473741 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT474273 LASP1 LIM and SH3 protein 1 2 2
MIRT477211 EVI5L ecotropic viral integration site 5 like 2 2
MIRT477700 EFHD2 EF-hand domain family member D2 2 2
MIRT477781 E2F3 E2F transcription factor 3 2 2
MIRT478657 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479241 CHTF8 chromosome transmission fidelity factor 8 2 2
MIRT481453 ARRB2 arrestin beta 2 2 2
MIRT482151 AK2 adenylate kinase 2 2 2
MIRT482660 FAM195B MAPK regulated corepressor interacting protein 1 2 4
MIRT483709 ASPH aspartate beta-hydroxylase 2 2
MIRT484556 BARHL1 BarH like homeobox 1 2 6
MIRT484675 ZBTB46 zinc finger and BTB domain containing 46 2 8
MIRT485697 CCDC64 BICD family like cargo adaptor 1 2 4
MIRT485948 BRSK1 BR serine/threonine kinase 1 2 2
MIRT486535 CLCN7 chloride voltage-gated channel 7 2 2
MIRT487030 LIMS2 LIM zinc finger domain containing 2 2 4
MIRT487048 C10orf55 chromosome 10 open reading frame 55 2 2
MIRT487089 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT487463 ANKRD42 ankyrin repeat domain 42 2 2
MIRT487485 BANP BTG3 associated nuclear protein 2 4
MIRT487882 CASZ1 castor zinc finger 1 2 4
MIRT488413 NKX6-2 NK6 homeobox 2 2 4
MIRT489230 ASCL2 achaete-scute family bHLH transcription factor 2 2 4
MIRT489300 B4GALNT4 beta-1,4-N-acetyl-galactosaminyltransferase 4 2 2
MIRT489364 SYNGR1 synaptogyrin 1 2 4
MIRT489480 SLITRK5 SLIT and NTRK like family member 5 2 2
MIRT489647 ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2 4
MIRT489664 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT490918 STRN4 striatin 4 2 2
MIRT491504 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT491626 RIN3 Ras and Rab interactor 3 2 2
MIRT491691 MNT MAX network transcriptional repressor 2 4
MIRT491894 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT491991 UNK unkempt family zinc finger 2 2
MIRT492114 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT492189 SOX12 SRY-box 12 5 2
MIRT492992 NAV1 neuron navigator 1 2 2
MIRT493009 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT493231 MEX3A mex-3 RNA binding family member A 2 2
MIRT493434 KCNK3 potassium two pore domain channel subfamily K member 3 2 2
MIRT493726 GPRIN1 G protein regulated inducer of neurite outgrowth 1 2 2
MIRT493983 EIF1 eukaryotic translation initiation factor 1 2 4
MIRT494370 SOLH calpain 15 1 1
MIRT494585 ATG9A autophagy related 9A 2 2
MIRT494665 ARL8A ADP ribosylation factor like GTPase 8A 2 2
MIRT494794 ANKRD13B ankyrin repeat domain 13B 2 4
MIRT496595 TAGLN transgelin 2 2
MIRT496775 ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 2 2
MIRT497819 STAT5B signal transducer and activator of transcription 5B 2 2
MIRT498182 CREB1 cAMP responsive element binding protein 1 2 2
MIRT499186 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT500208 MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2 4
MIRT501015 SPATA2 spermatogenesis associated 2 2 6
MIRT501095 SLC5A6 solute carrier family 5 member 6 2 4
MIRT507872 CBX6 chromobox 6 2 2
MIRT509415 MCM7 minichromosome maintenance complex component 7 2 6
MIRT544297 TSPYL1 TSPY like 1 2 2
MIRT552011 RAD18 RAD18, E3 ubiquitin protein ligase 2 2
MIRT561765 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT568305 BAK1 BCL2 antagonist/killer 1 2 2
MIRT573517 MMP17 matrix metallopeptidase 17 2 2
MIRT574579 NFIX nuclear factor I X 2 2
MIRT575680 Map1b microtubule-associated protein 1B 2 2
MIRT606935 CDK15 cyclin dependent kinase 15 2 2
MIRT642007 NCS1 neuronal calcium sensor 1 2 2
MIRT644451 ALDOC aldolase, fructose-bisphosphate C 2 2
MIRT654231 RNF165 ring finger protein 165 2 2
MIRT655874 NFASC neurofascin 2 2
MIRT661923 MLN motilin 2 2
MIRT692263 SLC2A5 solute carrier family 2 member 5 2 2
MIRT694387 MTA1 metastasis associated 1 2 2
MIRT705555 ARID5B AT-rich interaction domain 5B 2 2
MIRT710756 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT711005 CCDC106 coiled-coil domain containing 106 2 2
MIRT712118 TMEM11 transmembrane protein 11 2 2
MIRT713436 AJAP1 adherens junctions associated protein 1 2 2
MIRT722673 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT731653 FAM3A family with sequence similarity 3 member A 3 1
MIRT735672 USF2 upstream transcription factor 2, c-fos interacting 3 0
MIRT736182 CXCL12 C-X-C motif chemokine ligand 12 2 0
MIRT736539 TNIP2 TNFAIP3 interacting protein 2 2 0
MIRT737112 LOC105371414 uncharacterized LOC105371414 3 0
MIRT737113 ADCY3 adenylate cyclase 3 3 0
MIRT737402 CASC9 cancer susceptibility 9 (non-protein coding) 3 0
MIRT755749 SRF serum response factor 4 1
MIRT755800 CACNA2D2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 3 1
MIRT755861 MTM1 myotubularin 1 4 1
MIRT756274 SLIT2 slit guidance ligand 2 5 1
MIRT756275 PGM5-AS1 PGM5 antisense RNA 1 5 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-423 Bio-Oss NULL NULL Microarray osteoblast-like cell line (MG63) 20224834 2010 up-regulated
miR-423 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-423-5p 5-Fluorouracil approved 3385 Microarray HCT-116 colon cancer cell line 19956872 2010 down-regulated
miR-423-5p 5-Fluorouracil approved 3385 Microarray HCT-8 colon cancer cell line 19956872 2010 down-regulated
miR-423-5p Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-423-5p Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 down-regulated
miR-423-5p N-ethyl-N-nitrosourea NULL 12967 Quantitative real-time PCR mouse liver 21029445 2010 up-regulated
miR-423-5p Morphine approved 5288826 Microarray human monocyte-derived macrophages (h-mdms) infection with HIV-1 20564181 2010 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-423 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901)
hsa-mir-423 Paclitaxel 36314 NSC125973 approved sensitive cell line (HS578T)
hsa-mir-423 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-mir-423 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-423 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-423 Cisplatin 5460033 NSC119875 approved sensitive cell line (KYSE)
hsa-mir-423 Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-mir-423 Cisplatin 5460033 NSC119875 approved resistant cell line (SGC-7901)
hsa-miR-423-5p Cisplatin 5460033 NSC119875 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-423-5p Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-423-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7, PLC)
hsa-miR-423-5p Temozolomide 5394 NSC362856 approved resistant Low Glioma cell line (U87, U251)
hsa-miR-423-5p Epirubicin 41867 NSC256942 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-423-5p Vinorelbine 44424639 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-423-5p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-423-5p Fluorouracil 3385 NSC19893 approved sensitive High Colorectal Cancer cell line (DLD-1)
hsa-miR-423-5p Cisplatin 5460033 NSC119875 approved resistant Low Triple-Negative Breast Cancer cell line (MDA-MB-231)
hsa-miR-423-5p Cisplatin 5460033 NSC119875 approved resistant Low Triple-Negative Breast Cancer cell line (MDA-MB-231)
hsa-miR-423-5p Erlotinib 176870 NSC718781 approved resistant High Head And Neck Squamous Cell Carcinoma cell line (HN6)
hsa-miR-423-5p Paclitaxel 36314 NSC125973 approved sensitive High Breast Cancer cell line (BCap37)
hsa-miR-423-5p Imatinib 5291 NSC743414 approved sensitive Low Chronic Myelogenous Leukemia tissue
hsa-miR-423-5p Taxane 9548828 resistant Low Prostate Cancer cell line (LNCaP, 22Rv-1, C4-2)
hsa-miR-423-5p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (Huh-7, PLC)
hsa-miR-423-5p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-423-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-423-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (mitochondrial RNA)
hsa-miR-423-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-423-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-miR-423-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-423-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-423-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-423-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-423-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-423-5p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-423-5p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-423-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-423-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-423-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-423-5p Bortezomib 387447 NSC681239 approved resistant cell line (CCRF-CEM) (200 nM)
hsa-miR-423-5p Bortezomib 387447 NSC681239 approved resistant cell line (CCRF-CEM) (100 nM)
hsa-miR-423-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-423-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-423-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-423-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine sensitive cell line (Bats-72)
hsa-miR-423-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (OVSAHO)
hsa-miR-423-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (MDAH-2774)

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