miRTarBase - #MIRT038625


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pre-miRNA Information
pre-miRNA hsa-mir-125b-2   
Genomic Coordinates chr21: 16590237 - 16590325
Synonyms MIRN125B2, MIR125B2
Description Homo sapiens miR-125b-2 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-125b-2-3p
Sequence 54| UCACAAGUCAGGCUCUUGGGAC |75
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 21 + 16590292 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs575583557 6 dbSNP
rs1331783293 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KDELC2   
Synonyms -
Description KDEL motif containing 2
Transcript NM_153705   
Expression
Putative miRNA Targets on KDELC2
3'UTR of KDELC2
(miRNA target sites are highlighted)		 
>KDELC2|NM_153705|3'UTR
   1 GTCAGCCCAGAATCACACTCCTGTGTATCCCGGCTACACTTTAAGGAAAGATTGAATCTAAGCTGTGAAGGACAGTATAG
  81 AAGACTGCACCAAGTGGACTAGTTCTCCCGGTGGCTTTATATATGTAGATGGATATAGCAGTACTGGTTGAGTATCCCTC
 161 ATCTGAAATGCTTAGGACCAGGAGTGTTTCAGGCTTCAGATTTTTTAAGATTTGGGAATATTTGCATGTACATAATGAGG
 241 TATCTTGGGGATGAGATCCAAGTCTAAACACAAAATTCATTTATATTTTATATATACCTTGTTCACATACCCTGAAGGTA
 321 ATTTTATATAATATTTTTAATAATTTGTGCATGAAACAAAGTTTGTATACATTGAACTGTCAGAAAGCAAAGGTGTCACT
 401 ATCTTAGCGACCCAAGTGGTGGTGTCAGCACTCAAAAAGTTTTGGATTTTGGGGTATTTCAGATTTTAGATTTTTGTATG
 481 AGGAATGTTCAACCTGTATTTGAACAAGCATTACCAAATATCATTGAATATTAATATCTTTTGCGTAAAAACTGCTATTA
 561 TCAGCATCATAGTTTCTCTAAAAAGAAAACTTGGGGATCATAGCCGATAGAGAGACTTGCTAAAATATAAATCAGCCTCT
 641 GCAAAACTGTTTACATATTTATTGGTTTACATATTTTATTGGTTTATTTCTATCCCCTGTTCACTTTTTCTCTTCCACTT
 721 CCAATTATGAAGAGAAAATATTTGTTCAGGGTTGTCCCCCCGCCCCCCGTCACTGCATAATTTCTCCTCTTACAAGCTGC
 801 TTTTGGCTTTCATTAATAACAGCTTCCTTTTAGAAGGTCTGATAAGGATATTTAAGGAAGAAGAGAATGACTCTGTTATT
 881 AAAGGTGGCATGGAGACTGTGGAGGGAATATTTTTTAAAGCACTACTCATATCCTTTAAACTAAATTTTGCCAAAGCCCG
 961 AGACAACATTAAGGAGAAATTGTACCTTAAGTTAGTAATTCCAAATCTATCTGAGTTGTATACCCATCAAAGACAATACA
1041 GTTATTAACATAGATGAAGGTATGCTATAGGCATCATTCATTATCTCTATATTGAATAGGTGAAAGATAACTGTAGTCAG
1121 GTGAAAGGCATTCATTATTTTTAAGCTGAAAAGGGGATCCTTGAAAACACTGAAAACCTCTACAACAATCTTCAGGAAGC
1201 CTGCTATCTTGGGATTCACTAATAATAGGCCAAGAACAAAGGCAAGCATCCATTCCTCACTCCACCACTTTTCTATTTCA
1281 GTGGGTGTCGTTGCTACGATGAAGACTTTGGAAATTTCCTTTCTCTTTTAGGACAGGGTCAGGATTTAGGACTCATAGCC
1361 TGAAAGCTCATTACATACTCCTTGTAACCATCAGTCCAAGGTTCAGTTCACTAAAGTGCATGTTCTAAAACAAGAGCTAT
1441 CCTCATTCCAAATTTTAAAATATGTACTCTGGCCGGTTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGCAGGCCGA
1521 GATGGGCGGATCTTTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAA
1601 AAATTAGCCAGGCATGGTGGCATTTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGG
1681 AGGCAGAGGTTGCAGTGAGCTGAGATTACACCACTGCACTCCAGCCTGGGTGACAGAGTGAGACTCCATCTCAAAAACTG
1761 AAAATAAAAATAAAAATATGTATTCTCCTAACTGAAATATTTACTTAATCTGGAAAACAATGTAACTATTTTTAAAGTGG
1841 TTACATCTATTCTTGCTGAAGAACAATAAACAGAATTTTTTGACTAAGCATAACCAAATTTCAGAACAGTCTAATCAATG
1921 CCAAGTATCCAAGGCAAACTCTAATACCCATCCATTGTGCAAAACCACAAGCACGCAAGTATTAAATAAGAGCAAGCTGT
2001 CCTGAGCCCATACCTAATGAATTTGTGTCTTAAATATTGTACATTGTGTTTGAGGCTTGTCAAAACTGGGATTATGGCAA
2081 GAAAGGTTGCCTAACTCATACCTTTCTGCCTCAAATTCCAGGTGCTAAAGGCTAATGGCATTTTAAACATCTTACATTTT
2161 TAAAAATTTATATTGCCTCTGCCAAACAGGCCTAATAGTTAAAAGCAAGTTGAGACAAACCAGGCAGATTCAGTGTGTGG
2241 AACAGGAAGGATGTGCTTTAAAAAAAGGTGGAATCCCTCAAAAAATTCTATAGGGAGACAGCAGCCTTAATCTACATAAT
2321 TCTTCATCTCGCCAATTCAGCCGCAGCCTTTAAAGAGTTAGTGTTAATGGCTTTCTGGTTTGAAAACAAAAATGCATCTA
2401 TGTGGTTGAAAGTTTGGGAGGAGATTCACCAATATCTGAGGAGAAGATGGAGTGAAGGGAATTCTTACTTTTTGCTTTAT
2481 ACCTTTCTATAATATTTAGATTTTTTTTTACTGTAAGTATGGATCAAATTGCAAAATAAAGAAAAATGCCAACCTTAGAA
2561 AAGACAATAAATGCACAAAAGATATAAACAGGAACAGCAAATATTTATATTTTTTCCATTTTGCTCTTTTTAAATCTATG
2641 TTTAGAACTTTATATCTTGGGACTTATGTATATATATACCTTTTAAATAAAATAAATTTTCTAAATAAAAAGTTGAAAAA
2721 G
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cagGGUUCUCGG--AC-UGAACACu 5'
             || | | |:  || |:||||| 
Target 5' gagCCCATACCTAATGAATTTGTGt 3'
 2004 - 2028 133.00 -13.62
2 
miRNA  3' caggguucucggACUGAACACu 5'
                      | |:||||| 
Target 5' taatatttttaaTAATTTGTGc 3'
 329 - 350 126.00 -5.50
3 
miRNA  3' caggGUUCUCGGACUGAACacu 5'
              ||:|||  | |||||   
Target 5' gaggCAGGAGAATCACTTGaac 3'
 1654 - 1675 122.00 -11.82
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN22420264 6 COSMIC
COSN30494868 15 COSMIC
COSN20108718 38 COSMIC
COSN31599886 50 COSMIC
COSN31558177 54 COSMIC
COSN30705943 56 COSMIC
COSN24043296 58 COSMIC
COSN31558418 61 COSMIC
COSN30103666 166 COSMIC
COSN1126176 200 COSMIC
COSN31600335 286 COSMIC
COSN15662852 681 COSMIC
COSN16643829 1528 COSMIC
COSN15662619 1776 COSMIC
COSN25949185 1776 COSMIC
COSN5865624 1811 COSMIC
COSN8730852 2214 COSMIC
rs11374964 38 GWAS
rs7943203 1473 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1181750363 4 dbSNP
rs775326353 9 dbSNP
rs771883285 16 dbSNP
rs1168181243 17 dbSNP
rs1187770734 18 dbSNP
rs373401250 19 dbSNP
rs1016594337 20 dbSNP
rs1484667927 21 dbSNP
rs774380595 23 dbSNP
rs770726032 27 dbSNP
rs777352252 29 dbSNP
rs769637702 31 dbSNP
rs369930087 32 dbSNP
rs1343501624 36 dbSNP
rs758756012 37 dbSNP
rs750711847 38 dbSNP
rs11374964 39 dbSNP
rs201942465 39 dbSNP
rs757644547 41 dbSNP
rs753915164 51 dbSNP
rs951094490 52 dbSNP
rs1264056773 58 dbSNP
rs1488408721 68 dbSNP
rs1206302339 69 dbSNP
rs1261815604 72 dbSNP
rs150085579 76 dbSNP
rs997991027 78 dbSNP
rs1485694244 84 dbSNP
rs1422403168 88 dbSNP
rs552489585 91 dbSNP
rs1166739701 105 dbSNP
rs538240214 109 dbSNP
rs539435936 110 dbSNP
rs1289443012 122 dbSNP
rs558828735 123 dbSNP
rs903885298 129 dbSNP
rs1356261443 138 dbSNP
rs1043730458 152 dbSNP
rs774393876 171 dbSNP
rs780974586 177 dbSNP
rs1240346161 179 dbSNP
rs1263062605 182 dbSNP
rs547508372 207 dbSNP
rs1213780402 224 dbSNP
rs568918572 227 dbSNP
rs1056569095 236 dbSNP
rs1411354416 239 dbSNP
rs939496096 242 dbSNP
rs926904881 245 dbSNP
rs1319845319 252 dbSNP
rs567499618 255 dbSNP
rs1228697372 259 dbSNP
rs1376200642 269 dbSNP
rs1416849310 270 dbSNP
rs1360966673 273 dbSNP
rs962992610 279 dbSNP
rs1378868143 284 dbSNP
rs909564981 297 dbSNP
rs1392274515 301 dbSNP
rs982431295 304 dbSNP
rs550614026 305 dbSNP
rs77148558 307 dbSNP
rs1240081008 315 dbSNP
rs1348064301 317 dbSNP
rs200812998 317 dbSNP
rs1211761509 319 dbSNP
rs369177551 321 dbSNP
rs969900818 324 dbSNP
rs1482737507 330 dbSNP
rs1177502566 331 dbSNP
rs963837117 344 dbSNP
rs1360673714 346 dbSNP
rs185219231 348 dbSNP
rs750967528 350 dbSNP
rs1158041307 361 dbSNP
rs1395731160 364 dbSNP
rs1416287830 365 dbSNP
rs1423342018 367 dbSNP
rs995445580 371 dbSNP
rs1370683317 374 dbSNP
rs899336793 392 dbSNP
rs1443215738 400 dbSNP
rs1300207031 401 dbSNP
rs1166042396 408 dbSNP
rs1036448125 409 dbSNP
rs1000560731 421 dbSNP
rs140888299 423 dbSNP
rs1196132748 425 dbSNP
rs1478261346 429 dbSNP
rs1268350455 434 dbSNP
rs528732013 435 dbSNP
rs1220306635 443 dbSNP
rs904420905 453 dbSNP
rs762643678 469 dbSNP
rs1044143755 470 dbSNP
rs1009491904 478 dbSNP
rs1424571539 480 dbSNP
rs890680827 484 dbSNP
rs892567321 496 dbSNP
rs1398520938 500 dbSNP
rs1056433213 509 dbSNP
rs192734056 520 dbSNP
rs1397275193 524 dbSNP
rs1222133285 526 dbSNP
rs1272558143 531 dbSNP
rs1366371677 531 dbSNP
rs931650781 536 dbSNP
rs921719151 538 dbSNP
rs1279749640 543 dbSNP
rs1042805155 544 dbSNP
rs947091535 545 dbSNP
rs910106396 549 dbSNP
rs913073618 553 dbSNP
rs752374491 557 dbSNP
rs988621154 560 dbSNP
rs959973753 561 dbSNP
rs1196090139 563 dbSNP
rs922354875 567 dbSNP
rs1166032290 581 dbSNP
rs1393405861 598 dbSNP
rs976530508 604 dbSNP
rs928517287 605 dbSNP
rs982560014 606 dbSNP
rs1294635076 616 dbSNP
rs1018548112 619 dbSNP
rs1353181200 639 dbSNP
rs1173262020 641 dbSNP
rs1466369915 670 dbSNP
rs546485842 673 dbSNP
rs1197491163 677 dbSNP
rs1226508571 698 dbSNP
rs186902043 709 dbSNP
rs1447538106 713 dbSNP
rs994931986 720 dbSNP
rs1218835691 734 dbSNP
rs1261131083 743 dbSNP
rs963405905 746 dbSNP
rs1189002781 750 dbSNP
rs1015061460 756 dbSNP
rs1472041850 760 dbSNP
rs1191761638 761 dbSNP
rs1020132878 762 dbSNP
rs1449458347 762 dbSNP
rs761109112 763 dbSNP
rs1358143866 768 dbSNP
rs563296846 769 dbSNP
rs1334452574 782 dbSNP
rs1051966208 785 dbSNP
rs1342020691 786 dbSNP
rs1445481078 788 dbSNP
rs1283413417 790 dbSNP
rs996278840 796 dbSNP
rs1318274727 803 dbSNP
rs75432323 813 dbSNP
rs1242299997 823 dbSNP
rs900174269 831 dbSNP
rs1043077335 832 dbSNP
rs138083351 833 dbSNP
rs905266256 836 dbSNP
rs541915492 839 dbSNP
rs1211836718 864 dbSNP
rs947176291 873 dbSNP
rs1258467107 874 dbSNP
rs1332330660 877 dbSNP
rs1440938737 883 dbSNP
rs1045652880 890 dbSNP
rs1233827663 893 dbSNP
rs1442076696 895 dbSNP
rs781116598 899 dbSNP
rs1157455877 915 dbSNP
rs1377915251 917 dbSNP
rs1301344940 920 dbSNP
rs1418619289 926 dbSNP
rs1172679899 939 dbSNP
rs527747888 942 dbSNP
rs1391386141 944 dbSNP
rs1403856033 951 dbSNP
rs773725181 956 dbSNP
rs1412404648 958 dbSNP
rs772393419 959 dbSNP
rs565887867 960 dbSNP
rs938492877 967 dbSNP
rs553063235 969 dbSNP
rs928570084 977 dbSNP
rs182214686 985 dbSNP
rs1376091790 991 dbSNP
rs1234005649 1002 dbSNP
rs1257835485 1003 dbSNP
rs112140992 1005 dbSNP
rs1200147843 1009 dbSNP
rs1274149593 1011 dbSNP
rs1459403205 1013 dbSNP
rs1177293021 1017 dbSNP
rs1238052737 1018 dbSNP
rs916602816 1022 dbSNP
rs1047311796 1025 dbSNP
rs1198871363 1028 dbSNP
rs1158437580 1030 dbSNP
rs1418482359 1032 dbSNP
rs1378875695 1035 dbSNP
rs930202702 1036 dbSNP
rs774250918 1037 dbSNP
rs973781219 1040 dbSNP
rs145476091 1041 dbSNP
rs1014945428 1051 dbSNP
rs1399366637 1052 dbSNP
rs983625868 1053 dbSNP
rs954870576 1060 dbSNP
rs1242242044 1063 dbSNP
rs536948947 1066 dbSNP
rs768761350 1067 dbSNP
rs1030882801 1076 dbSNP
rs1279137721 1080 dbSNP
rs749413640 1089 dbSNP
rs1197098065 1092 dbSNP
rs979019096 1096 dbSNP
rs968539584 1099 dbSNP
rs1212213621 1100 dbSNP
rs900729213 1105 dbSNP
rs796722291 1108 dbSNP
rs140322747 1113 dbSNP
rs959932339 1116 dbSNP
rs1423843118 1120 dbSNP
rs780247892 1121 dbSNP
rs1168197379 1126 dbSNP
rs1422725854 1135 dbSNP
rs117051204 1142 dbSNP
rs1052848148 1153 dbSNP
rs1295266011 1155 dbSNP
rs1448096717 1173 dbSNP
rs1382583473 1174 dbSNP
rs1388642981 1180 dbSNP
rs938375622 1185 dbSNP
rs1386236688 1211 dbSNP
rs1298915724 1217 dbSNP
rs907035700 1219 dbSNP
rs535490070 1220 dbSNP
rs1044597499 1222 dbSNP
rs1398047873 1226 dbSNP
rs1322739722 1232 dbSNP
rs1247598515 1238 dbSNP
rs948676091 1246 dbSNP
rs568439048 1247 dbSNP
rs973454607 1248 dbSNP
rs1220996877 1258 dbSNP
rs1263286319 1266 dbSNP
rs1489056814 1268 dbSNP
rs1006141828 1275 dbSNP
rs888657112 1287 dbSNP
rs942035800 1288 dbSNP
rs72992191 1290 dbSNP
rs1366607617 1294 dbSNP
rs983508046 1297 dbSNP
rs1159269657 1298 dbSNP
rs1160397997 1308 dbSNP
rs954754139 1315 dbSNP
rs1398381463 1321 dbSNP
rs942354580 1324 dbSNP
rs1380193347 1334 dbSNP
rs1030518521 1336 dbSNP
rs1311033478 1359 dbSNP
rs1321577920 1367 dbSNP
rs1440222224 1368 dbSNP
rs1241572212 1375 dbSNP
rs975288135 1381 dbSNP
rs1286101003 1396 dbSNP
rs1355273898 1400 dbSNP
rs745601425 1409 dbSNP
rs1213982102 1410 dbSNP
rs1384451108 1414 dbSNP
rs1185098241 1418 dbSNP
rs1443833159 1419 dbSNP
rs566954152 1422 dbSNP
rs965012624 1444 dbSNP
rs1253834553 1448 dbSNP
rs1487031432 1451 dbSNP
rs1443919493 1457 dbSNP
rs1287527916 1462 dbSNP
rs1382223509 1471 dbSNP
rs7943203 1473 dbSNP
rs1158156410 1474 dbSNP
rs947124142 1475 dbSNP
rs146720845 1476 dbSNP
rs1301443489 1477 dbSNP
rs1247478079 1482 dbSNP
rs757101386 1490 dbSNP
rs751537513 1491 dbSNP
rs1312163994 1494 dbSNP
rs891475960 1497 dbSNP
rs959962845 1503 dbSNP
rs1341408609 1504 dbSNP
rs928531537 1505 dbSNP
rs1282952569 1514 dbSNP
rs552878804 1516 dbSNP
rs111695956 1518 dbSNP
rs189557021 1519 dbSNP
rs1254025725 1522 dbSNP
rs148953773 1526 dbSNP
rs1199060589 1527 dbSNP
rs1298875077 1528 dbSNP
rs948542790 1530 dbSNP
rs1437753253 1531 dbSNP
rs1176634637 1554 dbSNP
rs529760134 1555 dbSNP
rs559171907 1563 dbSNP
rs1420268108 1568 dbSNP
rs1389897366 1570 dbSNP
rs1435119237 1570 dbSNP
rs1161341204 1578 dbSNP
rs1038244941 1581 dbSNP
rs541129345 1582 dbSNP
rs1005673391 1583 dbSNP
rs186626143 1591 dbSNP
rs1446714269 1601 dbSNP
rs1047697441 1606 dbSNP
rs757948681 1615 dbSNP
rs933420802 1621 dbSNP
rs752315131 1622 dbSNP
rs1278433431 1627 dbSNP
rs1367779144 1635 dbSNP
rs1220567888 1638 dbSNP
rs1298675215 1645 dbSNP
rs764924801 1646 dbSNP
rs1025846067 1652 dbSNP
rs994308356 1676 dbSNP
rs974977074 1687 dbSNP
rs759268144 1692 dbSNP
rs1456373833 1699 dbSNP
rs1476634021 1707 dbSNP
rs1264754269 1709 dbSNP
rs1247331243 1714 dbSNP
rs558737266 1715 dbSNP
rs1041257756 1722 dbSNP
rs990403715 1724 dbSNP
rs1006973675 1728 dbSNP
rs1478276127 1738 dbSNP
rs1173204659 1739 dbSNP
rs1422004911 1742 dbSNP
rs889493146 1767 dbSNP
rs1324829938 1772 dbSNP
rs1490030790 1779 dbSNP
rs1437937671 1781 dbSNP
rs1291290741 1782 dbSNP
rs1288389340 1785 dbSNP
rs956252275 1792 dbSNP
rs1357510528 1799 dbSNP
rs1218926517 1819 dbSNP
rs145729180 1828 dbSNP
rs947187701 1836 dbSNP
rs1002526774 1837 dbSNP
rs1217101199 1846 dbSNP
rs1290441277 1847 dbSNP
rs1052904403 1851 dbSNP
rs971195854 1852 dbSNP
rs1023135429 1853 dbSNP
rs116714119 1861 dbSNP
rs898330300 1873 dbSNP
rs1278971020 1890 dbSNP
rs1196204414 1903 dbSNP
rs1261444732 1907 dbSNP
rs1404435505 1909 dbSNP
rs928564468 1915 dbSNP
rs1164228689 1928 dbSNP
rs1416502533 1929 dbSNP
rs1404110456 1935 dbSNP
rs1329375821 1941 dbSNP
rs1364483402 1943 dbSNP
rs1038131242 1949 dbSNP
rs767951621 1958 dbSNP
rs980077842 1959 dbSNP
rs1299703911 1974 dbSNP
rs970378354 1975 dbSNP
rs1284576322 1977 dbSNP
rs916607966 1979 dbSNP
rs1407004915 1981 dbSNP
rs1004105853 1986 dbSNP
rs952785958 1987 dbSNP
rs1219046630 1993 dbSNP
rs1284089093 1997 dbSNP
rs886999861 1999 dbSNP
rs1391271858 2000 dbSNP
rs1188608720 2014 dbSNP
rs1239638818 2015 dbSNP
rs1025710429 2018 dbSNP
rs1047750799 2036 dbSNP
rs1384048574 2044 dbSNP
rs1419719703 2046 dbSNP
rs1159961510 2061 dbSNP
rs1382241681 2066 dbSNP
rs1399770064 2070 dbSNP
rs1334553803 2074 dbSNP
rs1169658355 2076 dbSNP
rs149760534 2078 dbSNP
rs1425360774 2083 dbSNP
rs1193888425 2091 dbSNP
rs923412119 2103 dbSNP
rs965500946 2106 dbSNP
rs542723766 2111 dbSNP
rs1350210496 2119 dbSNP
rs1201311928 2125 dbSNP
rs1244416755 2130 dbSNP
rs1441093269 2135 dbSNP
rs1039534885 2138 dbSNP
rs943425304 2148 dbSNP
rs1007167823 2151 dbSNP
rs1442093832 2152 dbSNP
rs762136468 2155 dbSNP
rs1452684203 2159 dbSNP
rs535449519 2161 dbSNP
rs914743591 2168 dbSNP
rs1197112498 2171 dbSNP
rs990287740 2177 dbSNP
rs1469309275 2184 dbSNP
rs1172842229 2186 dbSNP
rs956304010 2188 dbSNP
rs568451639 2191 dbSNP
rs553146349 2197 dbSNP
rs1335878547 2205 dbSNP
rs1400866282 2208 dbSNP
rs535141314 2209 dbSNP
rs774893325 2214 dbSNP
rs570925307 2220 dbSNP
rs1335289456 2223 dbSNP
rs1365596792 2224 dbSNP
rs1234204219 2227 dbSNP
rs1276687246 2233 dbSNP
rs17108054 2234 dbSNP
rs374709653 2240 dbSNP
rs1331587373 2245 dbSNP
rs1321708324 2246 dbSNP
rs971464456 2249 dbSNP
rs531159602 2260 dbSNP
rs1013083857 2267 dbSNP
rs962470757 2270 dbSNP
rs1197380180 2271 dbSNP
rs1247773865 2276 dbSNP
rs1016739588 2291 dbSNP
rs1003991138 2297 dbSNP
rs1198982971 2300 dbSNP
rs1177969520 2302 dbSNP
rs1378965478 2313 dbSNP
rs1479258655 2314 dbSNP
rs1175426006 2316 dbSNP
rs570362563 2322 dbSNP
rs548937592 2330 dbSNP
rs371750370 2331 dbSNP
rs529615961 2333 dbSNP
rs1387382037 2339 dbSNP
rs984157077 2342 dbSNP
rs1413540376 2343 dbSNP
rs931261008 2346 dbSNP
rs1320500620 2347 dbSNP
rs1422524841 2351 dbSNP
rs1225847367 2354 dbSNP
rs901841364 2356 dbSNP
rs57618209 2357 dbSNP
rs201350383 2373 dbSNP
rs1357714104 2377 dbSNP
rs147842700 2382 dbSNP
rs386757317 2382 dbSNP
rs1270481689 2392 dbSNP
rs965448787 2396 dbSNP
rs1198288738 2401 dbSNP
rs1177269919 2408 dbSNP
rs878904254 2412 dbSNP
rs1019810069 2414 dbSNP
rs943461620 2417 dbSNP
rs559303050 2418 dbSNP
rs893212496 2425 dbSNP
rs1054650798 2426 dbSNP
rs1458357246 2433 dbSNP
rs1022256110 2436 dbSNP
rs1011207407 2449 dbSNP
rs934814839 2451 dbSNP
rs11686 2454 dbSNP
rs982109888 2464 dbSNP
rs1380848039 2473 dbSNP
rs1295315811 2478 dbSNP
rs950291776 2481 dbSNP
rs1350001222 2482 dbSNP
rs1051141 2483 dbSNP
rs1293282504 2494 dbSNP
rs991144450 2499 dbSNP
rs962807807 2500 dbSNP
rs1237800418 2502 dbSNP
rs1002603060 2510 dbSNP
rs1286233791 2510 dbSNP
rs531984632 2511 dbSNP
rs1184497649 2512 dbSNP
rs1260852509 2515 dbSNP
rs1424326932 2520 dbSNP
rs1189591856 2522 dbSNP
rs1378914837 2526 dbSNP
rs1383436410 2529 dbSNP
rs1331784276 2560 dbSNP
rs906931935 2567 dbSNP
rs1362623755 2573 dbSNP
rs1446883790 2576 dbSNP
rs1288647814 2588 dbSNP
rs1403403015 2589 dbSNP
rs1044248439 2591 dbSNP
rs1016621674 2592 dbSNP
rs1335722039 2595 dbSNP
rs982612005 2607 dbSNP
rs1414575492 2615 dbSNP
rs1379083313 2623 dbSNP
rs951223671 2626 dbSNP
rs1029409027 2628 dbSNP
rs1213297130 2629 dbSNP
rs746272755 2638 dbSNP
rs184087061 2639 dbSNP
rs1482453998 2648 dbSNP
rs1241158351 2661 dbSNP
rs1443940214 2662 dbSNP
rs373903026 2667 dbSNP
rs1410334075 2678 dbSNP
rs192206150 2679 dbSNP
rs887701412 2680 dbSNP
rs1007540325 2695 dbSNP
rs1048974144 2697 dbSNP
rs1467864467 2701 dbSNP
rs1237950326 2708 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cagGGUUCUCGG--AC-UGAACACu 5'
             || | | |:  || |:||||| 
Target 5' gagCCCATACCTAATGAATTTGTGt 3'
 		12 - 36
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38226 Liver fibrosis 0.677 3.7e-4 0.379 4.5e-2 21 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.527 3.4e-3 0.389 2.7e-2 25 Click to see details
GSE28544 Breast cancer -0.482 8.5e-3 -0.462 1.2e-2 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.457 1.4e-2 0.322 6.7e-2 23 Click to see details
GSE19783 ER+ ER+ breast cancer 0.329 7.8e-2 0.229 1.7e-1 20 Click to see details
GSE19783 ER- ER- breast cancer 0.149 9.5e-2 0.129 1.3e-1 79 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.932 1.2e-1 -1.000 5.0e-1 3 Click to see details
GSE19350 CNS germ cell tumors 0.367 1.2e-1 0.376 1.1e-1 12 Click to see details
GSE21687 Ependynoma primary tumors -0.103 2.1e-1 -0.020 4.4e-1 64 Click to see details
GSE26953 Aortic valvular endothelial cells -0.15 2.4e-1 -0.128 2.8e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.15 2.6e-1 -0.077 3.7e-1 20 Click to see details
GSE28260 Renal cortex and medulla 0.16 3.0e-1 0.220 2.4e-1 13 Click to see details
GSE19536 Breast cancer -0.032 3.8e-1 -0.023 4.1e-1 100 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.065 3.8e-1 0.002 5.0e-1 25 Click to see details
GSE32688 Pancreatic cancer -0.051 3.9e-1 -0.045 4.0e-1 32 Click to see details
GSE21032 Prostate cancer 0.026 4.1e-1 0.025 4.1e-1 83 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUAD -0.797 0 -0.748 0 12 Click to see details
STAD 0.5 0 0.471 0 32 Click to see details
LIHC 0.205 0.08 0.116 0.21 49 Click to see details
THCA -0.169 0.1 -0.166 0.1 59 Click to see details
UCEC 0.302 0.1 0.323 0.09 19 Click to see details
CESC 0.935 0.12 1.000 0.5 3 Click to see details
ESCA 0.368 0.13 0.236 0.24 11 Click to see details
KICH -0.23 0.13 -0.248 0.12 25 Click to see details
LUSC 0.178 0.14 0.180 0.14 38 Click to see details
CHOL 0.35 0.18 0.400 0.14 9 Click to see details
PAAD 0.605 0.2 0.400 0.3 4 Click to see details
COAD 0.326 0.22 0.500 0.1 8 Click to see details
BRCA 0.079 0.24 0.117 0.14 84 Click to see details
BLCA 0.178 0.24 -0.055 0.41 18 Click to see details
KIRP 0.128 0.24 0.149 0.21 32 Click to see details
PRAD -0.052 0.36 -0.082 0.29 50 Click to see details
KIRC -0.043 0.36 -0.103 0.2 68 Click to see details
HNSC -0.037 0.41 0.019 0.45 42 Click to see details
PCPG -0.058 0.48 0.500 0.33 3 Click to see details
PCPG -0.058 0.48 0.500 0.33 3 Click to see details
PCPG -0.058 0.48 0.500 0.33 3 Click to see details
91 hsa-miR-125b-2-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038624 HN1L Jupiter microtubule associated homolog 2 1 1
MIRT038625 KDELC2 KDEL motif containing 2 1 1
MIRT038626 ABHD15 abhydrolase domain containing 15 1 1
MIRT038627 PPP1R12C protein phosphatase 1 regulatory subunit 12C 1 1
MIRT038628 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 1 1
MIRT038629 ASH2L ASH2 like histone lysine methyltransferase complex subunit 1 1
MIRT038630 USP22 ubiquitin specific peptidase 22 1 1
MIRT038631 CSTB cystatin B 1 1
MIRT038632 SYT2 synaptotagmin 2 1 1
MIRT038633 NDUFS7 NADH:ubiquinone oxidoreductase core subunit S7 1 1
MIRT038634 MTA2 metastasis associated 1 family member 2 1 1
MIRT053086 IGF1R insulin like growth factor 1 receptor 3 1
MIRT055788 PLEKHA1 pleckstrin homology domain containing A1 2 12
MIRT061248 AMOTL1 angiomotin like 1 2 10
MIRT061649 BTG2 BTG anti-proliferation factor 2 2 6
MIRT079046 TNRC6C trinucleotide repeat containing 6C 2 4
MIRT084583 BCL2L11 BCL2 like 11 2 8
MIRT093523 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 2
MIRT097383 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT098030 SOBP sine oculis binding protein homolog 2 2
MIRT186262 TCEB3 elongin A 2 2
MIRT187284 DAZAP2 DAZ associated protein 2 2 10
MIRT361113 LRRC1 leucine rich repeat containing 1 2 2
MIRT443585 FAM84B family with sequence similarity 84 member B 2 2
MIRT452249 TRAM1 translocation associated membrane protein 1 2 2
MIRT476289 GMFB glia maturation factor beta 2 8
MIRT483871 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT484250 ANK1 ankyrin 1 2 2
MIRT499251 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502270 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504652 RPL9 ribosomal protein L9 2 6
MIRT505210 UBN2 ubinuclein 2 2 6
MIRT512690 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT517341 ZNF529 zinc finger protein 529 2 4
MIRT518946 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520866 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT521236 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT528324 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT533297 USP46 ubiquitin specific peptidase 46 2 2
MIRT541024 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT544034 ERRFI1 ERBB receptor feedback inhibitor 1 2 2
MIRT547037 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556102 MOAP1 modulator of apoptosis 1 2 2
MIRT558320 DR1 down-regulator of transcription 1 2 2
MIRT558520 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT566230 PTMA prothymosin, alpha 2 4
MIRT568437 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570584 OTUD7B OTU deubiquitinase 7B 2 2
MIRT571384 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572798 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573864 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT609930 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610437 CSMD2 CUB and Sushi multiple domains 2 2 2
MIRT614407 MURC caveolae associated protein 4 2 2
MIRT618625 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620605 SAP30 Sin3A associated protein 30 2 2
MIRT635313 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635918 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT638507 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT640597 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT644066 IQCE IQ motif containing E 2 2
MIRT648287 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT653089 SSR3 signal sequence receptor subunit 3 2 2
MIRT654651 PTAFR platelet activating factor receptor 2 2
MIRT658084 FOXR2 forkhead box R2 2 2
MIRT665306 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665974 SYTL4 synaptotagmin like 4 2 2
MIRT674905 RASSF9 Ras association domain family member 9 2 2
MIRT680085 THAP1 THAP domain containing 1 2 2
MIRT681487 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691243 DFNB59 pejvakin 2 2
MIRT692361 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693034 MB21D1 Mab-21 domain containing 1 2 2
MIRT694478 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696069 ZNF264 zinc finger protein 264 2 2
MIRT696579 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696759 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697306 ZNF652 zinc finger protein 652 2 2
MIRT698736 STX12 syntaxin 12 2 2
MIRT701055 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701197 OTUD3 OTU deubiquitinase 3 2 2
MIRT701334 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT703617 FBXO45 F-box protein 45 2 2
MIRT708893 ZNF780A zinc finger protein 780A 2 2
MIRT711621 DGKH diacylglycerol kinase eta 2 2
MIRT713744 TMEM81 transmembrane protein 81 2 2
MIRT715060 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT719711 CD101 CD101 molecule 2 2
MIRT720293 DLGAP3 DLG associated protein 3 2 2
MIRT722605 CCDC152 coiled-coil domain containing 152 2 2
MIRT724565 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-125b-2 Ascorbate approved 54670067 Microarray Metastatic melanoma cell lines 25202679 2014 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-125b-2 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-125b-2 Methotrexate 126941 NSC740 approved resistant High Colorectal Adenocarcinoma cell line (HT-29)
hsa-mir-125b-2 Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia tissue
hsa-mir-125b-2 Doxorubicin 31703 NSC123127 approved sensitive Low Hepatocellular Carcinoma cell line (Huh-7, HLE, HuH1)
hsa-mir-125b-2 Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375)
hsa-mir-125b-2 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-125b-2 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-125b-2 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-mir-125b-2 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-125b-2 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-125b-2 Tamoxifen 2733525 NSC180973 approved resistant tissue (ER-positive breast cancer)
hsa-mir-125b-2 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-mir-125b-2 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-125b-2-3p Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901)
hsa-miR-125b-2-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-125b-2-3p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-125b-2-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-125b-2-3p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-125b-2-3p Cyclophosphamide + Doxorubicin + Vincristine + Prednisone + Rituximab resistant High Diffuse Large B-Cell Lymphoma cell line (SU-DHL-2)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC-7901, BGC-823)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Lung Adenocarcinoma cell line (A549)
hsa-miR-125b-2-3p Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (HCT8, HCT-116)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-miR-125b-2-3p Antiepileptic Drug sensitive High Pediatric Epilepsy tissue
hsa-miR-125b-2-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-125b-2-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-125b-2-3p 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-miR-125b-2-3p Ethanol+Tamoxifen resistant cell line (LY2)
hsa-miR-125b-2-3p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-125b-2-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-125b-2-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-125b-2-3p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR70)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-125b-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-125b-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-125b-2-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (SGC-7901)
hsa-miR-125b-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)

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