miRTarBase - #MIRT038676


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pre-miRNA Information
pre-miRNA hsa-mir-10a   
Genomic Coordinates chr17: 48579838 - 48579947
Synonyms MIRN10A, hsa-mir-10a, miRNA10A, mir-10a, MIR10A
Description Homo sapiens miR-10a stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-10a-3p
Sequence 63| CAAAUUCGUAUCUAGGGGAAUA |84
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31530247 3 COSMIC
COSN23022313 7 COSMIC
COSN4892854 9 COSMIC
COSN30141482 12 COSMIC
COSN30107865 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1333780611 1 dbSNP
rs764734216 1 dbSNP
rs768238280 8 dbSNP
rs749109017 16 dbSNP
rs779774585 17 dbSNP
rs1228091752 19 dbSNP
rs1348797754 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B6HZE2 miR-10a Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Muscle Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol GCFC2   
Synonyms C2orf3, DNABF, GCF, TCF9
Description GC-rich sequence DNA-binding factor 2
Transcript NM_003203   
Expression
Putative miRNA Targets on GCFC2
3'UTR of GCFC2
(miRNA target sites are highlighted)		 
>GCFC2|NM_003203|3'UTR
   1 ATAAACTTTATTGGAAAATGCTAAAATTTTAATATAGTTACACTCAGTTCCTTTGTTTGAGAAGAAGCTGGTGCCTCTCT
  81 CTTCTTTATTCCCTGTAATAGAAGGTAGGATTTGAAAAAAAGCAGGACTCCACCTCTGTATTCCCCCGTGCTTTACCTTC
 161 TGGCATCATGAAAAGCTGCCATGATTCTGTGGTGTTCTAAGGAATTAAATGCACTGGAGCTTTAAGAGCTCAACGTGTTT
 241 CCCTTTGATTCTTTTGGCTGGTCTTTCAATTTTCTTAAGAGGGGAACTGGAGAAACCTTGCTAAAGGTTTTAGCTTAAGT
 321 GAGCATGCTACTAAGTCTTCTGTCCTGAACCACAATAATATCTTTTAGTTCTCTTTAACTACCTTTATTTAAAAATAAGT
 401 CAATATGAAAATCTCAGTTGGAGTGAATTATTTGCTAAGTATTAAATGATTAAGGCATGTGCCGATTGTCAAATTATCCT
 481 TCAGAAATCTGTACCAATTTAATGTACCAACATAAGCATAAGTGAGTGCCAATGAATCCCTACCAGCAGTAGTTATTATC
 561 CTTTTTAAAAATGCATTGAAAATTTGAAAGGTAAAAATCTTATTTTAATAGCGTATTTTGTGTTGGCTATTAGAGAGTAA
 641 ACATATTGGTTTTGGCCATTTGTAATTATTTCTGAAATATCCATCTTTTTCTTATGGACTTTAAGACCTTTATATTTTTA
 721 AAGATATTGATTTTTTGCCCATGCTTGTGGCAGAAGTTTTCCTTATTTGCCATTTTTCTTTTATTTTTTTTTTAATTGTA
 801 TTTTTTGAGACAGGGTCTGGCTCTGTCACCCAGGCTGGAGAGTAGTGGCACAATCTCGGCTCACTGCAACCTCTGCCTTC
 881 TGGGCTCAAGCAATCCTCCCACTTCAACCTCCCAAGTAGCTGGGACTATAGGCATGCGCCACCATGCCCAGCTGATTTTT
 961 GTAATTTTTTGTAGAGATGGGGTTTCGTGACATTGCCCAGGCTGGTCTCGAACTCTTGAGCTCAAGCAGTCTACCCACCT
1041 TGACCTCCCAAAGTGCTGGGATTACAGGCTTGAGCAACCATGTTTGGCCTTTCTTTTAAATTTGTTGATGTTTTTTGAAG
1121 CATTAAGTCATTACTTATTAGCAAGTTACTATTTTGTTTTTTTGTCATTGGTGGTAGGACTAAGAAGGAAACAGATATTT
1201 TAAATACTCACAACATGTGATTCATTTTCTGATAAAATATTTGTCTAATAAAACAGAGGCAAGATAATTTAATCAAAAGA
1281 AATTAAGAAAATTTTCCAAAAATGTTAGTTTACTAGTAATTTTTCTAAGTCTACTTATTAAATAACTTAAGGGAAACTGT
1361 AAATATATTTTGCAAATTGTTGTTCAAAAGATAATTGGAAAAAATTGAATATATTGTAGGATTTGAATATACAGCCTACT
1441 TTTATGTCACCTCTACCTTCAAAACTACATATAATTTATTTTAGGAGTTGGATTTGTTATGTCTGTTGCAGTGAGGACTT
1521 GTGATTCACTGGTATGAAGAATTTTTTGATGTTTATATTAGTAACAAAATTATACAAGGATAGAATCTCATCTAGAAAAT
1601 GCAAACTATTGTTGAAAAGCAGTTAGCATTTCCACACAACCGCTGTCCCCAGAGATAACTGCTGTTTTCATTTTAATGTT
1681 ATCCTTTTAGACCTTTTCTCTATTTACAAAAATGTTACGTGTTTCTATGTGTACATAGTTTTGGGTTTTTTTTTTTTTTT
1761 TACGTAAGTGGCAGACACTTTATTGCACATGAAATTTGTAATTTTTTTCTATTTAAGTACACATTTGGAAATTATCCTCT
1841 GACTTTTGGATTTTTAACTAAATATGTTGGACGTGTTCCTTTATATATTTAAGTTCAGCACAGAAACTTTCCTACCTTTT
1921 TGTGGAAGATAAAATATTAAAACTGCTTTCAAAACTACAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auaAGGGGAUC-UA-UGCUUAAAc 5'
             |:| ||:| || | |||||| 
Target 5' tgaTTCACTGGTATGAAGAATTTt 3'
 1522 - 1545 131.00 -9.47
2 
miRNA  3' auaAGGGGAUCU------AUGCUUAAAc 5'
             |||:: |||      ||| ||||| 
Target 5' ttaTCCTTCAGAAATCTGTACCAATTTa 3'
 474 - 501 129.00 -5.30
3 
miRNA  3' auaAGGGGAUCU--AUGCUUAAAc 5'
             |||:|| ||  | :|:|||| 
Target 5' ttaTCCTCT-GACTTTTGGATTTt 3'
 1832 - 1854 128.00 -11.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26977233 28 COSMIC
COSN31587302 40 COSMIC
COSN20090563 59 COSMIC
COSN31581220 136 COSMIC
COSN19187251 1065 COSMIC
COSN7083415 1156 COSMIC
COSN17656507 1325 COSMIC
COSN6684557 1411 COSMIC
COSN19334401 1745 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs778613764 6 dbSNP
rs754640236 7 dbSNP
rs753483316 8 dbSNP
rs1427261676 19 dbSNP
rs374183618 20 dbSNP
rs1178755684 25 dbSNP
rs1485849335 35 dbSNP
rs760170684 37 dbSNP
rs1247742957 40 dbSNP
rs755693804 41 dbSNP
rs749882011 44 dbSNP
rs768200687 45 dbSNP
rs1170517521 57 dbSNP
rs1376637379 60 dbSNP
rs1405834909 61 dbSNP
rs1392835606 64 dbSNP
rs536306971 76 dbSNP
rs925369505 83 dbSNP
rs1375700097 86 dbSNP
rs1415712923 87 dbSNP
rs557216857 88 dbSNP
rs763572981 91 dbSNP
rs566166558 94 dbSNP
rs757877067 95 dbSNP
rs1423880641 97 dbSNP
rs1195482640 99 dbSNP
rs1296350764 104 dbSNP
rs551902548 106 dbSNP
rs77017723 108 dbSNP
rs1282691315 115 dbSNP
rs528335474 121 dbSNP
rs1348873220 122 dbSNP
rs1215549214 130 dbSNP
rs775056366 131 dbSNP
rs1019839213 135 dbSNP
rs986710035 144 dbSNP
rs954735135 147 dbSNP
rs187497624 148 dbSNP
rs1453800438 149 dbSNP
rs951240885 152 dbSNP
rs759895642 169 dbSNP
rs776888559 175 dbSNP
rs62148720 176 dbSNP
rs1395252249 191 dbSNP
rs1418773332 192 dbSNP
rs545113342 195 dbSNP
rs182869343 198 dbSNP
rs956788378 201 dbSNP
rs530850640 203 dbSNP
rs532227404 211 dbSNP
rs905350660 233 dbSNP
rs1385083127 234 dbSNP
rs1023879625 235 dbSNP
rs1348850122 256 dbSNP
rs905379071 261 dbSNP
rs1013772342 269 dbSNP
rs1318553027 279 dbSNP
rs896185720 284 dbSNP
rs1046686265 286 dbSNP
rs1487473530 289 dbSNP
rs753944368 296 dbSNP
rs1436983035 297 dbSNP
rs929734249 298 dbSNP
rs1052426601 303 dbSNP
rs936658163 326 dbSNP
rs577843421 337 dbSNP
rs1402766663 339 dbSNP
rs898206041 344 dbSNP
rs1460463458 354 dbSNP
rs975538684 360 dbSNP
rs1400307890 362 dbSNP
rs1460388165 366 dbSNP
rs1327997000 367 dbSNP
rs115867062 383 dbSNP
rs1446297166 401 dbSNP
rs942586169 406 dbSNP
rs911056644 411 dbSNP
rs912402536 416 dbSNP
rs1418397268 417 dbSNP
rs986741095 425 dbSNP
rs1224064262 435 dbSNP
rs1311815046 441 dbSNP
rs933865607 453 dbSNP
rs923284665 455 dbSNP
rs574404847 458 dbSNP
rs559448891 460 dbSNP
rs190310296 463 dbSNP
rs764028053 464 dbSNP
rs1234190673 466 dbSNP
rs962381677 468 dbSNP
rs1260018327 470 dbSNP
rs1032461395 480 dbSNP
rs1413603823 494 dbSNP
rs1196867383 497 dbSNP
rs577048404 504 dbSNP
rs1395882590 522 dbSNP
rs558746018 532 dbSNP
rs756246828 533 dbSNP
rs1279669781 535 dbSNP
rs1023745653 536 dbSNP
rs1219576487 540 dbSNP
rs1443290608 540 dbSNP
rs116799899 543 dbSNP
rs1272863940 545 dbSNP
rs951161860 549 dbSNP
rs1293793258 552 dbSNP
rs1440007730 554 dbSNP
rs1216192174 560 dbSNP
rs1025175618 561 dbSNP
rs748247186 575 dbSNP
rs993816563 576 dbSNP
rs1209031343 577 dbSNP
rs144192902 580 dbSNP
rs1484867336 588 dbSNP
rs12999961 593 dbSNP
rs1190550623 597 dbSNP
rs1419126548 598 dbSNP
rs1332753069 602 dbSNP
rs185504278 607 dbSNP
rs1410725261 612 dbSNP
rs536695664 613 dbSNP
rs936896891 629 dbSNP
rs889635459 634 dbSNP
rs1423424934 636 dbSNP
rs1050891449 641 dbSNP
rs933896622 642 dbSNP
rs767789970 643 dbSNP
rs182826891 646 dbSNP
rs1339535953 648 dbSNP
rs986654701 649 dbSNP
rs1277698819 650 dbSNP
rs929780681 654 dbSNP
rs1213391664 656 dbSNP
rs1258740702 657 dbSNP
rs191115437 670 dbSNP
rs1191730103 677 dbSNP
rs1457418879 682 dbSNP
rs935384829 692 dbSNP
rs185866405 693 dbSNP
rs779222354 695 dbSNP
rs113108448 699 dbSNP
rs1359706705 700 dbSNP
rs1380432458 701 dbSNP
rs980168776 703 dbSNP
rs1320144835 704 dbSNP
rs1326986243 705 dbSNP
rs1435042749 715 dbSNP
rs969417491 719 dbSNP
rs971210673 720 dbSNP
rs1023778189 723 dbSNP
rs573576869 727 dbSNP
rs1350350636 731 dbSNP
rs1311445102 733 dbSNP
rs892649615 737 dbSNP
rs1448099798 738 dbSNP
rs1031106686 742 dbSNP
rs1001077221 744 dbSNP
rs904071656 750 dbSNP
rs1194554353 765 dbSNP
rs1379935733 770 dbSNP
rs1371899144 771 dbSNP
rs1451307317 783 dbSNP
rs75904148 783 dbSNP
rs201853653 784 dbSNP
rs144854986 785 dbSNP
rs1025931675 788 dbSNP
rs994827461 793 dbSNP
rs113918596 794 dbSNP
rs1308028775 794 dbSNP
rs942675152 794 dbSNP
rs1333630343 796 dbSNP
rs891237963 802 dbSNP
rs570631839 822 dbSNP
rs780821208 823 dbSNP
rs1352030863 830 dbSNP
rs1213660485 831 dbSNP
rs1271324111 833 dbSNP
rs1017000302 840 dbSNP
rs1469838595 842 dbSNP
rs1214426735 844 dbSNP
rs1006657524 858 dbSNP
rs1382690836 860 dbSNP
rs889498914 869 dbSNP
rs1183702406 873 dbSNP
rs930019555 877 dbSNP
rs1472414131 880 dbSNP
rs1162643005 884 dbSNP
rs757125136 893 dbSNP
rs1038175325 895 dbSNP
rs1330113826 900 dbSNP
rs1414556460 906 dbSNP
rs552418105 907 dbSNP
rs1331259496 917 dbSNP
rs891631566 921 dbSNP
rs1053065660 923 dbSNP
rs1482377922 924 dbSNP
rs935902229 927 dbSNP
rs1233913824 932 dbSNP
rs1257137275 937 dbSNP
rs1209871336 938 dbSNP
rs1479777241 941 dbSNP
rs925321353 943 dbSNP
rs1197829395 952 dbSNP
rs1488532394 953 dbSNP
rs1044095631 961 dbSNP
rs28532717 964 dbSNP
rs916630397 967 dbSNP
rs1419873981 969 dbSNP
rs1475529968 973 dbSNP
rs992197318 978 dbSNP
rs971458241 985 dbSNP
rs1370886712 992 dbSNP
rs1463177027 1003 dbSNP
rs761788364 1007 dbSNP
rs139631806 1009 dbSNP
rs988540605 1017 dbSNP
rs1316289507 1018 dbSNP
rs918733511 1020 dbSNP
rs955752394 1027 dbSNP
rs1312756012 1028 dbSNP
rs1229574444 1033 dbSNP
rs1416008143 1034 dbSNP
rs1294904611 1038 dbSNP
rs1305791992 1039 dbSNP
rs1229746503 1040 dbSNP
rs1347447174 1044 dbSNP
rs1208450655 1050 dbSNP
rs1259439647 1069 dbSNP
rs973040337 1072 dbSNP
rs1001435456 1075 dbSNP
rs963262628 1089 dbSNP
rs1429730273 1090 dbSNP
rs1016600913 1093 dbSNP
rs1292361125 1097 dbSNP
rs1400992508 1104 dbSNP
rs1432542089 1105 dbSNP
rs1362777508 1107 dbSNP
rs1435755420 1111 dbSNP
rs1288758782 1120 dbSNP
rs1006525827 1122 dbSNP
rs953683537 1123 dbSNP
rs1296463828 1129 dbSNP
rs547875667 1138 dbSNP
rs1370529733 1143 dbSNP
rs1232424483 1147 dbSNP
rs1007112232 1157 dbSNP
rs1348262679 1171 dbSNP
rs891137185 1172 dbSNP
rs1453616845 1187 dbSNP
rs1258818469 1192 dbSNP
rs1486812559 1194 dbSNP
rs1029456607 1195 dbSNP
rs1251907731 1211 dbSNP
rs551759968 1212 dbSNP
rs1166965626 1215 dbSNP
rs1195162673 1217 dbSNP
rs994260997 1228 dbSNP
rs190351320 1238 dbSNP
rs559171671 1244 dbSNP
rs1158855275 1249 dbSNP
rs17011638 1252 dbSNP
rs548012935 1253 dbSNP
rs1478930292 1259 dbSNP
rs1053333797 1264 dbSNP
rs752224608 1266 dbSNP
rs1000136704 1274 dbSNP
rs1372001622 1286 dbSNP
rs1222934206 1290 dbSNP
rs1224054081 1297 dbSNP
rs1203193493 1313 dbSNP
rs1304671369 1328 dbSNP
rs927262656 1329 dbSNP
rs904399956 1333 dbSNP
rs949975453 1335 dbSNP
rs1223113972 1336 dbSNP
rs1466720644 1346 dbSNP
rs764901302 1349 dbSNP
rs768013682 1351 dbSNP
rs1271996960 1361 dbSNP
rs532090298 1365 dbSNP
rs565094834 1368 dbSNP
rs1218799879 1370 dbSNP
rs988404555 1377 dbSNP
rs948091309 1379 dbSNP
rs17011637 1384 dbSNP
rs1160497514 1385 dbSNP
rs1417810104 1400 dbSNP
rs36116275 1402 dbSNP
rs939427013 1404 dbSNP
rs1295869081 1405 dbSNP
rs1441838315 1410 dbSNP
rs181613594 1410 dbSNP
rs1375319326 1437 dbSNP
rs1224149647 1439 dbSNP
rs1292529755 1446 dbSNP
rs546578441 1448 dbSNP
rs761184672 1451 dbSNP
rs1007555799 1453 dbSNP
rs1467338299 1456 dbSNP
rs1202067271 1462 dbSNP
rs1481802529 1469 dbSNP
rs542640382 1471 dbSNP
rs955573748 1473 dbSNP
rs1257355381 1474 dbSNP
rs1474544817 1475 dbSNP
rs572432057 1481 dbSNP
rs1414675473 1484 dbSNP
rs1190727069 1501 dbSNP
rs994166555 1505 dbSNP
rs1267972135 1512 dbSNP
rs1356498034 1529 dbSNP
rs796574709 1532 dbSNP
rs985705831 1534 dbSNP
rs897267581 1550 dbSNP
rs1410142254 1555 dbSNP
rs1038451314 1557 dbSNP
rs762056723 1565 dbSNP
rs1353482954 1567 dbSNP
rs1467098051 1568 dbSNP
rs1271933568 1572 dbSNP
rs1005606462 1575 dbSNP
rs553900871 1578 dbSNP
rs1029319355 1581 dbSNP
rs1319522801 1587 dbSNP
rs950018959 1595 dbSNP
rs539101576 1600 dbSNP
rs1280147806 1601 dbSNP
rs955960094 1603 dbSNP
rs1484958187 1604 dbSNP
rs1031506322 1606 dbSNP
rs571779772 1608 dbSNP
rs774991685 1609 dbSNP
rs904348622 1611 dbSNP
rs1184871659 1623 dbSNP
rs1421900019 1627 dbSNP
rs1430718752 1629 dbSNP
rs1313076464 1631 dbSNP
rs1172751640 1637 dbSNP
rs1373453608 1640 dbSNP
rs558740599 1641 dbSNP
rs537290969 1642 dbSNP
rs1325795575 1647 dbSNP
rs895182467 1651 dbSNP
rs773792402 1660 dbSNP
rs771822150 1674 dbSNP
rs1233160200 1678 dbSNP
rs911386328 1680 dbSNP
rs1332084994 1682 dbSNP
rs1280031712 1685 dbSNP
rs188919747 1689 dbSNP
rs115374124 1692 dbSNP
rs1279884946 1695 dbSNP
rs1037110222 1699 dbSNP
rs1213731711 1702 dbSNP
rs1243958892 1707 dbSNP
rs941562413 1709 dbSNP
rs548501175 1712 dbSNP
rs1393540516 1714 dbSNP
rs529963383 1718 dbSNP
rs932861064 1719 dbSNP
rs1377932092 1722 dbSNP
rs779468650 1729 dbSNP
rs757715380 1736 dbSNP
rs1177993533 1737 dbSNP
rs1452456676 1738 dbSNP
rs1252345077 1739 dbSNP
rs922281045 1741 dbSNP
rs1178692883 1743 dbSNP
rs1458760527 1744 dbSNP
rs1277347067 1745 dbSNP
rs73936764 1746 dbSNP
rs567173416 1747 dbSNP
rs1300753221 1748 dbSNP
rs1016913486 1749 dbSNP
rs1006054783 1750 dbSNP
rs767730058 1751 dbSNP
rs1023246971 1752 dbSNP
rs1222614225 1761 dbSNP
rs1014022265 1762 dbSNP
rs1198318863 1762 dbSNP
rs1408708864 1762 dbSNP
rs199648088 1762 dbSNP
rs879027983 1762 dbSNP
rs1468513098 1763 dbSNP
rs895773603 1763 dbSNP
rs1347761736 1764 dbSNP
rs1323325521 1766 dbSNP
rs1310701442 1770 dbSNP
rs1396218593 1771 dbSNP
rs1387035123 1772 dbSNP
rs1324594780 1779 dbSNP
rs1052976614 1781 dbSNP
rs1237377803 1782 dbSNP
rs76738743 1785 dbSNP
rs1328287541 1786 dbSNP
rs1232732317 1789 dbSNP
rs1271418908 1792 dbSNP
rs532030470 1798 dbSNP
rs1210711993 1802 dbSNP
rs1250105054 1807 dbSNP
rs1184084445 1809 dbSNP
rs1252376040 1809 dbSNP
rs904217227 1809 dbSNP
rs1474878633 1820 dbSNP
rs1419453219 1822 dbSNP
rs1063988 1829 dbSNP
rs1396775331 1832 dbSNP
rs1404664333 1833 dbSNP
rs1042702000 1841 dbSNP
rs1393889354 1841 dbSNP
rs530582058 1848 dbSNP
rs955823977 1853 dbSNP
rs1389975543 1856 dbSNP
rs1310306161 1858 dbSNP
rs1031873797 1873 dbSNP
rs943142521 1876 dbSNP
rs910283674 1879 dbSNP
rs17011635 1886 dbSNP
rs1159106286 1887 dbSNP
rs1441477197 1892 dbSNP
rs1337710716 1898 dbSNP
rs1207017920 1902 dbSNP
rs544911575 1910 dbSNP
rs1275136765 1915 dbSNP
rs1361502954 1918 dbSNP
rs1216628035 1925 dbSNP
rs1180507363 1931 dbSNP
rs1185650125 1938 dbSNP
rs1258220973 1942 dbSNP
rs968981683 1952 dbSNP
rs1442608911 1961 dbSNP
rs1370976245 1962 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site CDS
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' auaAGGGGAUCUAUGCUUAAac 5'
             ||||||| ||||||:||  
Target 5' aaaTCCCCTA-ATACGAGTTca 3'
 		2 - 22
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.606 8.5e-4 -0.528 4.0e-3 24 Click to see details
GSE21687 Ependynoma primary tumors 0.283 1.2e-2 0.211 4.7e-2 64 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.426 1.7e-2 -0.406 2.2e-2 25 Click to see details
GSE19536 Breast cancer -0.156 6.1e-2 -0.208 1.9e-2 100 Click to see details
GSE19783 ER- ER- breast cancer -0.154 8.8e-2 -0.197 4.1e-2 79 Click to see details
GSE38226 Liver fibrosis -0.278 1.1e-1 -0.470 1.6e-2 21 Click to see details
GSE19350 CNS germ cell tumors 0.287 1.8e-1 0.427 8.3e-2 12 Click to see details
GSE26953 Aortic valvular endothelial cells -0.129 2.7e-1 -0.126 2.8e-1 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.112 3.1e-1 -0.140 2.6e-1 23 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.101 3.2e-1 0.344 4.6e-2 25 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.356 3.2e-1 0.600 2.0e-1 4 Click to see details
GSE28260 Renal cortex and medulla 0.132 3.3e-1 0.181 2.8e-1 13 Click to see details
GSE32688 Pancreatic cancer 0.077 3.4e-1 0.121 2.5e-1 32 Click to see details
GSE17498 Multiple myeloma 0.036 4.1e-1 -0.097 2.8e-1 40 Click to see details
GSE19783 ER+ ER+ breast cancer -0.039 4.4e-1 -0.060 4.0e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.032 4.5e-1 0.152 2.6e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BLCA -0.68 0 -0.499 0.03 14 Click to see details
HNSC -0.318 0.06 -0.320 0.06 26 Click to see details
KIRP 0.27 0.07 0.239 0.09 32 Click to see details
KIRC 0.173 0.08 0.169 0.09 65 Click to see details
STAD -0.246 0.09 -0.176 0.17 31 Click to see details
COAD 0.529 0.18 0.300 0.31 5 Click to see details
PCPG 0.77 0.22 0.500 0.33 3 Click to see details
PRAD -0.179 0.23 -0.015 0.47 20 Click to see details
UCEC 0.194 0.23 0.348 0.09 17 Click to see details
KICH 0.137 0.26 0.204 0.16 25 Click to see details
CHOL 0.238 0.27 0.467 0.1 9 Click to see details
THCA 0.065 0.35 0.169 0.16 38 Click to see details
LUAD 0.124 0.35 0.021 0.47 12 Click to see details
BRCA 0.043 0.36 0.001 0.5 74 Click to see details
LIHC -0.042 0.39 -0.057 0.35 45 Click to see details
PAAD -0.154 0.42 -0.600 0.2 4 Click to see details
ESCA 0.066 0.43 0.127 0.36 10 Click to see details
LUSC 0.006 0.49 0.072 0.33 38 Click to see details
LUSC 0.006 0.49 0.072 0.33 38 Click to see details
LUSC 0.006 0.49 0.072 0.33 38 Click to see details
LUSC 0.006 0.49 0.072 0.33 38 Click to see details
62 hsa-miR-10a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038671 VPS13D vacuolar protein sorting 13 homolog D 1 1
MIRT038672 GTF2I general transcription factor IIi 1 1
MIRT038673 ACLY ATP citrate lyase 1 1
MIRT038674 CLIC4 chloride intracellular channel 4 1 1
MIRT038675 NCBP2 nuclear cap binding protein subunit 2 1 1
MIRT038676 GCFC2 GC-rich sequence DNA-binding factor 2 1 1
MIRT056055 COMMD3 COMM domain containing 3 2 6
MIRT080401 ONECUT2 one cut homeobox 2 2 2
MIRT089339 PCBP1 poly(rC) binding protein 1 2 2
MIRT217793 HBS1L HBS1 like translational GTPase 2 2
MIRT281381 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT303046 B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2 4
MIRT446082 RCOR3 REST corepressor 3 2 2
MIRT446109 TSC22D2 TSC22 domain family member 2 2 2
MIRT448460 SMC3 structural maintenance of chromosomes 3 2 2
MIRT449067 ZNF24 zinc finger protein 24 2 2
MIRT449685 CDR1 cerebellar degeneration related protein 1 2 2
MIRT450363 GRAMD3 GRAM domain containing 2B 2 2
MIRT463590 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT466662 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT467571 SLITRK4 SLIT and NTRK like family member 4 2 2
MIRT468557 SERINC3 serine incorporator 3 2 10
MIRT469840 R3HDM4 R3H domain containing 4 2 2
MIRT476235 GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2 2
MIRT480076 CALU calumenin 2 4
MIRT480825 BLCAP bladder cancer associated protein 2 10
MIRT485713 CASP16 caspase 16, pseudogene 2 8
MIRT500591 UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 2 4
MIRT507451 EIF6 eukaryotic translation initiation factor 6 2 2
MIRT507470 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 6
MIRT508618 HOXC4 homeobox C4 2 8
MIRT525776 SOD2 superoxide dismutase 2 2 2
MIRT529014 GYPA glycophorin A (MNS blood group) 2 2
MIRT536731 IGF1 insulin like growth factor 1 2 2
MIRT537307 FRS2 fibroblast growth factor receptor substrate 2 2 2
MIRT548439 ELMOD2 ELMO domain containing 2 2 2
MIRT550928 ATG2B autophagy related 2B 2 2
MIRT552415 ZNF460 zinc finger protein 460 2 4
MIRT553138 UBE2H ubiquitin conjugating enzyme E2 H 2 2
MIRT554946 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT556315 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT557057 HOXB3 homeobox B3 2 2
MIRT557743 FUT4 fucosyltransferase 4 2 2
MIRT558489 DBN1 drebrin 1 2 2
MIRT559638 AKAP10 A-kinase anchoring protein 10 2 2
MIRT568118 CDC27 cell division cycle 27 2 2
MIRT574413 TFAP2A transcription factor AP-2 alpha 2 2
MIRT611420 ZNF431 zinc finger protein 431 2 4
MIRT616545 NFATC2 nuclear factor of activated T-cells 2 2 2
MIRT628408 C1orf21 chromosome 1 open reading frame 21 2 2
MIRT629513 QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2 2
MIRT635884 SIX3 SIX homeobox 3 2 2
MIRT643154 GOLIM4 golgi integral membrane protein 4 2 2
MIRT645603 MRPS15 mitochondrial ribosomal protein S15 2 2
MIRT654270 RGS17 regulator of G protein signaling 17 2 2
MIRT658811 EFNA5 ephrin A5 2 2
MIRT659613 CELSR2 cadherin EGF LAG seven-pass G-type receptor 2 2 2
MIRT697603 YAP1 Yes associated protein 1 2 2
MIRT700703 PODXL podocalyxin like 2 2
MIRT705319 ATP6V1G1 ATPase H+ transporting V1 subunit G1 2 2
MIRT721291 TRABD2A TraB domain containing 2A 2 2
MIRT734812 EPHA8 EPH receptor A8 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-10a RAR-alpha antagonist Ro-41-5253 NULL NULL Northern blot pancreatic cancer 19747919 2009 down-regulated
miR-10a 5-Fluorouracil approved 3385 Microarray HCT-8 colon cancer cell line 19956872 2010 down-regulated
miR-10a Oxaliplatin (L-OHP) approved 5310940 Microarray HCT-116 colon cancer cell line 19956872 2010 down-regulated
miR-10a Mistletoe lectin-I NULL NULL Microarray colorectal cancer cells HT-29 cells 20955366 2011 down-regulated
miR-10a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-10a All-trans-retinoic acid (ATRA) approved 444795 Microarray acute myeloid leukemia (AML) cell line HL-60 21518431 2011 down-regulated
miR-10a Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-10a All-trans-retinoic acid (ATRA) approved 444795 Quantitative real-time PCR regulatory T cells (T(reg) cells) 22544395 2012 up-regulated
miR-10a Glucocorticoid NULL NULL Quantitative real-time PCR Eosinophilic esophagitis 22815788 2012 up-regulated
miR-10a Glucocorticoid NULL NULL TaqMan low-density array Eosinophilic esophagitis 22815788 2012 up-regulated
miR-10a Galactose NULL 6036 Quantitative real-time PCR lens 22736950 2012 up-regulated
miR-10a Ethanol NULL 702 Microarray fetal mouse brains 19091803 2009 up-regulated
miR-10a Ethanol NULL 702 Northern blot fetal mouse brains 19091803 2009 up-regulated
miR-10a Ethanol NULL 702 Quantitative real-time PCR fetal mouse brains 19091803 2009 up-regulated
miR-10a Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 down-regulated
miR-10a Longevinex NULL NULL Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 down-regulated
miR-10a Longevinex NULL NULL Quantitative real-time PCR normal heart 21203465 2011 up-regulated
miR-10a Resveratrol NULL 445154 Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 down-regulated
miR-10a Resveratrol NULL 445154 Quantitative real-time PCR normal heart 21203465 2011 up-regulated
miR-10a Aristolochic acid NULL 2236 Microarray kidney 25106556 2014 up-regualted
miR-10a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-10a Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-10a Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-10a Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-10a Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-10a Methotrexate 126941 NSC740 approved sensitive cell line (W1)
hsa-mir-10a Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-mir-10a Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-10a Androstenedione 6128 NSC9563 resistant cell line (MCF-7)
hsa-mir-10a Tamoxifen 2733525 NSC180973 approved sensitive tissue (ER-positive breast cancer)
hsa-mir-10a Fluorouracil 3385 NSC19893 approved sensitive cell line (OE19)
hsa-mir-10a Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-mir-10a Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-mir-10a Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-10a-3p Temozolomide 5394 NSC362856 approved sensitive Low Glioblastoma cell line (U251MG)
hsa-miR-10a-3p Cisplatin 5460033 NSC119875 approved sensitive High Lung Adenocarcinoma cell line (A549)
hsa-miR-10a-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-10a-3p Doxorubicin 31703 NSC123127 approved resistant High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-10a-3p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-10a-3p Cisplatin 5460033 NSC119875 approved sensitive High Gallbladder Cancer cell line (GBC-SD, NOZ)
hsa-miR-10a-3p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-10a-3p Trastuzumab resistant High Breast Cancer cell line (MDA‐MB‐231, SKBR3, HEK‐293T)
hsa-miR-10a-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-10a-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-10a-3p Antiepileptic Drug sensitive High Pediatric Epilepsy tissue
hsa-miR-10a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-10a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-10a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-10a-3p Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-10a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-10a-3p Fluorouracil 3385 NSC19893 approved sensitive cell line (HCT15)
hsa-miR-10a-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-10a-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-10a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-10a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-10a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-10a-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-10a-3p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-10a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)

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