miRTarBase - #MIRT038999


—
pre-miRNA Information
pre-miRNA hsa-let-7a-1   
Genomic Coordinates chr9: 94175957 - 94176036
Synonyms LET7A1, MIRNLET7A1, let-7a-1, MIRLET7A1
Description Homo sapiens let-7a-1 stem-loop
Comment let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-let-7a-3   
Genomic Coordinates chr22: 46112749 - 46112822
Synonyms LET7A3, MIRNLET7A3, let-7a-3, MIRLET7A3
Description Homo sapiens let-7a-3 stem-loop
Comment let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-let-7a-3p
Sequence 57| CUAUACAAUCUACUGUCUUUC |77
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 9 + 94176017 29233923 MiREDiBase
A-to-I 5 22 + 46112804 29233923 MiREDiBase
A-to-I 12 22 + 46112811 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs972845958 1 dbSNP
rs781681931 2 dbSNP
rs748585376 3 dbSNP
rs779353569 6 dbSNP
rs1198423693 8 dbSNP
rs970921980 8 dbSNP
rs372596018 9 dbSNP
rs770208205 10 dbSNP
rs1453867589 11 dbSNP
rs1399588338 15 dbSNP
rs1219969167 16 dbSNP
rs1265084977 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SETD4   
Synonyms C21orf18, C21orf27
Description SET domain containing 4
Transcript NM_017438   
Other Transcripts NM_001007259   
Expression
Putative miRNA Targets on SETD4
3'UTR of SETD4
(miRNA target sites are highlighted)		 
>SETD4|NM_017438|3'UTR
   1 TTTCACCGAAGCGCATTTGGTCACCTCCTCTGAAACAAAAGTTAATTTTGAAGAGCATCATCATGGGCTGGGGTGGTGGC
  81 TGCCCCCAGGACATGCAGGATTTCTGCAGGGGGCAGCACAGGTTCTGGGATTGTGAGGCTGTGAGTGAAGGTGGACAAGC
 161 TGTCTGGATGGCAGGTCTAATGCTCTTCCGAATAAAGTGCTGAACTGTGAGGAGAGAGGCGGACTGTGAGGCAGCCAGGA
 241 GCCAGCTGCGTCCGTGTGTGGTCTGTCACCACGGGGCCTGCTTCTTATCTGACACAGCAGCTATCAGAGTCTAGTGGTTG
 321 TGCTTTTAAGATGCTCTGATACCATTGGGTTAAGGGGCAGATTGGCGGTGGGTGTGGGGCAGTGTGAGGTAGTCCTGGAT
 401 CCCCGCCAGGGTGGCCCAGACGCCAGCCCTTCCCTGTGTGGCTGCACTGAGGTGGGTGTTGAAGAGCCCCCTAGGGGACA
 481 CACAGCTTCCAGGAGGAGGGAATGTCCTCTAAGCATGCTCCTGGCCTCTCAAGGTGGCGCTTGTCTAATTATTCACTTGG
 561 GAAGAATGACTAGCTCAGCCAGCGGCTCTTTCTGCTTTGTTCTGGCGACTTTCCTGGGCAGGCCTTTCCACCTGGGGAGC
 641 TGGCTCATCCTGCACAGCTGGGCCGTGGTGGGCCTGTCTGCTTGATTCTGGGGTTCAGTGTAGGTCAGCTGATGGCGAAC
 721 CATGGTGGTGGTTTGGCTTCTGTTCTTATTCTTGAGTTTTGATACCACGCAGACCTTGGGTGGGGAGAGCTTCCTGCACA
 801 GCTCTCAGCGGCCTGTGGCCTTGGAACTGCCTGCGTAAGTAACGGAGGGGCTGCTGGTCCTGTTCAGGCCCGTGCTGGGG
 881 ACGCCGCTTAGACAATGTTGCCCAGAGTCCTGTTTACCCTCCCAGGGTTCATTCTTCCCAAGAACTCAAATTCCTTTCTC
 961 ATTGGAGCCTAGTGAAACCAAATGAACGGGACCTGCTGGCCTCAGGAGGCAGGCAGAGTTTAAAATAAAACTTTCTCATG
1041 ATTTCTTGAACATCTTTCCCTGTTTGTATATACACTTTGTGTTTATTTTTCAGTAGCTGCAGTATATTTTTTTTCAATAT
1121 TCAGTATAATGCAGTGTATTTCATCATATGCTGTATGGAGAGTGGGCAGACTTCTGTGGAGGGCCCGATAGTAACCATTT
1201 GAAGCTTTCTGGACCTGTGGTCTTAGTCCCAGCGATTCTGCAGAGCGGCCATCGGCAGCATGTCAACCATTTGCATGGCT
1281 GGGCTCCAGGGAAACTACTGACAACGACAGGTGGTGGGCCATAGTTTCCTGACCCCTGTGCTATGCCAGAATTTCTTTTT
1361 CCTCTTCCCTATGAGTGGACCTAAATATGTTAATTCCTTTTCACCTTTCAAAACGGACAGCCCCTTGAACATTAAAAACT
1441 TCGCAGACCCTAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuUUCUG-UCAUCUAACAUauc 5'
            :|| | ||| |:||||:   
Target 5' caGAGTCTAGT-GGTTGTGctt 3'
 305 - 325 102.00 -9.82
2 
miRNA  3' cuUUCUGUC----A-UCUAACAUauc 5'
            |: ||||    | :||||||:   
Target 5' gcAGCACAGGTTCTGGGATTGTGagg 3'
 113 - 138 101.00 -11.40
3 
miRNA  3' cuuucugucaucuaaCAUAUc 5'
                         ||||| 
Target 5' ttttcagtagctgcaGTATAt 3'
 1087 - 1107 100.00 -7.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30629774 5 COSMIC
COSN30475318 6 COSMIC
COSN19771748 7 COSMIC
COSN30702476 8 COSMIC
COSN23019793 30 COSMIC
COSN30190557 37 COSMIC
COSN21853310 43 COSMIC
COSN31535989 95 COSMIC
COSN16961950 104 COSMIC
COSN30157332 108 COSMIC
COSN30083319 110 COSMIC
COSN30473650 132 COSMIC
COSN30102854 138 COSMIC
COSN20079928 139 COSMIC
COSN30105172 165 COSMIC
COSN25787807 265 COSMIC
COSN4973507 482 COSMIC
COSN1256303 872 COSMIC
COSN32057113 958 COSMIC
COSN5986222 1010 COSMIC
COSN19210457 1273 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs895272989 2 dbSNP
rs1263579520 4 dbSNP
rs776971398 4 dbSNP
rs866949184 6 dbSNP
rs768979083 7 dbSNP
rs747415463 8 dbSNP
rs776027138 10 dbSNP
rs370579915 11 dbSNP
rs116084907 12 dbSNP
rs779217837 13 dbSNP
rs769409421 15 dbSNP
rs773888607 16 dbSNP
rs747596488 20 dbSNP
rs1481457063 24 dbSNP
rs373548966 26 dbSNP
rs1476678316 29 dbSNP
rs754660465 33 dbSNP
rs199927897 36 dbSNP
rs751167141 37 dbSNP
rs772677622 40 dbSNP
rs779842645 45 dbSNP
rs1485996036 48 dbSNP
rs375055977 49 dbSNP
rs986515488 69 dbSNP
rs1409177083 81 dbSNP
rs544902069 81 dbSNP
rs957501286 83 dbSNP
rs183948948 89 dbSNP
rs770922932 92 dbSNP
rs746388966 95 dbSNP
rs562887125 96 dbSNP
rs1255634407 97 dbSNP
rs989906831 99 dbSNP
rs977638075 100 dbSNP
rs966372053 101 dbSNP
rs544311840 110 dbSNP
rs1207411531 113 dbSNP
rs1400369720 128 dbSNP
rs1482999550 150 dbSNP
rs957169196 154 dbSNP
rs1269900803 155 dbSNP
rs1172134138 158 dbSNP
rs192023257 160 dbSNP
rs139581918 179 dbSNP
rs896254071 182 dbSNP
rs1033417145 184 dbSNP
rs1475563092 185 dbSNP
rs1169900992 190 dbSNP
rs1368238332 191 dbSNP
rs1191492081 192 dbSNP
rs566020550 196 dbSNP
rs1303700986 205 dbSNP
rs1002012338 207 dbSNP
rs1384893949 220 dbSNP
rs998760704 236 dbSNP
rs971374183 245 dbSNP
rs111973733 252 dbSNP
rs887576988 255 dbSNP
rs781646873 269 dbSNP
rs1455535414 284 dbSNP
rs757723740 284 dbSNP
rs929263948 289 dbSNP
rs1230941660 290 dbSNP
rs1025395345 292 dbSNP
rs1013549658 312 dbSNP
rs540738472 313 dbSNP
rs1197919477 317 dbSNP
rs1487680622 327 dbSNP
rs895147781 328 dbSNP
rs573425927 331 dbSNP
rs1040804246 337 dbSNP
rs1458311212 339 dbSNP
rs558435137 340 dbSNP
rs16993814 344 dbSNP
rs147369958 345 dbSNP
rs936163793 352 dbSNP
rs1279790800 354 dbSNP
rs1164089313 370 dbSNP
rs926073490 373 dbSNP
rs778479283 374 dbSNP
rs967656943 378 dbSNP
rs754497088 380 dbSNP
rs1318802991 391 dbSNP
rs1309241312 392 dbSNP
rs556102035 396 dbSNP
rs1314997368 405 dbSNP
rs960380297 411 dbSNP
rs1051784883 412 dbSNP
rs1244780953 426 dbSNP
rs537408665 433 dbSNP
rs1331672885 437 dbSNP
rs1210132385 438 dbSNP
rs1377030052 448 dbSNP
rs1245847543 452 dbSNP
rs1299335485 466 dbSNP
rs535842073 470 dbSNP
rs1358146020 474 dbSNP
rs1181914499 478 dbSNP
rs1176326502 490 dbSNP
rs989880743 496 dbSNP
rs143168609 497 dbSNP
rs1436418434 499 dbSNP
rs1421983436 501 dbSNP
rs1378224538 519 dbSNP
rs548622422 519 dbSNP
rs1164071300 523 dbSNP
rs1001868641 528 dbSNP
rs188041454 529 dbSNP
rs779545982 531 dbSNP
rs1453701374 536 dbSNP
rs1027479502 541 dbSNP
rs1304652432 545 dbSNP
rs1024193295 546 dbSNP
rs1180123247 549 dbSNP
rs1225003458 552 dbSNP
rs1482965932 565 dbSNP
rs1256873375 590 dbSNP
rs755988511 594 dbSNP
rs1352671862 600 dbSNP
rs1213265999 602 dbSNP
rs1352018892 603 dbSNP
rs1328016217 604 dbSNP
rs1210471568 611 dbSNP
rs1257233356 614 dbSNP
rs1481998521 620 dbSNP
rs1181147840 624 dbSNP
rs991830050 629 dbSNP
rs533688484 637 dbSNP
rs1473558225 640 dbSNP
rs959380002 642 dbSNP
rs1285701649 645 dbSNP
rs144212092 649 dbSNP
rs182958152 652 dbSNP
rs1319188884 658 dbSNP
rs1178520268 659 dbSNP
rs767259626 662 dbSNP
rs995534596 662 dbSNP
rs1309114844 663 dbSNP
rs551199149 663 dbSNP
rs889090680 664 dbSNP
rs1393856548 673 dbSNP
rs1346603816 679 dbSNP
rs761558007 690 dbSNP
rs1015710940 691 dbSNP
rs190832897 698 dbSNP
rs1208848094 699 dbSNP
rs1274780934 703 dbSNP
rs936111572 707 dbSNP
rs1203002823 708 dbSNP
rs926021153 709 dbSNP
rs1478234950 716 dbSNP
rs568513600 716 dbSNP
rs1423350781 717 dbSNP
rs1432870955 726 dbSNP
rs751787402 730 dbSNP
rs764283908 731 dbSNP
rs1428368661 740 dbSNP
rs1054157178 748 dbSNP
rs1423374515 749 dbSNP
rs935735240 755 dbSNP
rs924318965 764 dbSNP
rs1294875181 765 dbSNP
rs1256919222 770 dbSNP
rs1218344477 771 dbSNP
rs201693393 773 dbSNP
rs1297675900 776 dbSNP
rs977615634 785 dbSNP
rs1273864845 788 dbSNP
rs562609450 801 dbSNP
rs1223467790 802 dbSNP
rs949888301 804 dbSNP
rs1217717128 805 dbSNP
rs1487050417 812 dbSNP
rs775651071 813 dbSNP
rs917508233 817 dbSNP
rs760619203 818 dbSNP
rs550864656 819 dbSNP
rs993067512 822 dbSNP
rs1447740878 823 dbSNP
rs1320635168 824 dbSNP
rs1293316614 832 dbSNP
rs550202057 835 dbSNP
rs1415191659 836 dbSNP
rs1337874214 840 dbSNP
rs562065156 841 dbSNP
rs962687772 846 dbSNP
rs926330129 849 dbSNP
rs79734726 855 dbSNP
rs573413690 859 dbSNP
rs1291759016 862 dbSNP
rs955543927 872 dbSNP
rs777259950 873 dbSNP
rs1269127925 878 dbSNP
rs1356926142 887 dbSNP
rs1030272676 891 dbSNP
rs140250265 892 dbSNP
rs546107932 893 dbSNP
rs961874597 894 dbSNP
rs1054716889 898 dbSNP
rs1250172001 900 dbSNP
rs999829637 902 dbSNP
rs1019286394 904 dbSNP
rs1238186992 919 dbSNP
rs760076462 926 dbSNP
rs1474049669 933 dbSNP
rs902866140 934 dbSNP
rs1413436760 944 dbSNP
rs1476965080 946 dbSNP
rs1159377518 948 dbSNP
rs777314165 958 dbSNP
rs1194638483 959 dbSNP
rs767163878 961 dbSNP
rs1265668166 967 dbSNP
rs372934453 968 dbSNP
rs1050453570 970 dbSNP
rs1209802503 973 dbSNP
rs1228805034 983 dbSNP
rs1000184863 989 dbSNP
rs1489060285 992 dbSNP
rs937270411 995 dbSNP
rs1215095566 996 dbSNP
rs1444201571 1004 dbSNP
rs904632589 1007 dbSNP
rs1185995584 1009 dbSNP
rs1041800850 1010 dbSNP
rs757943666 1011 dbSNP
rs946221803 1018 dbSNP
rs973300357 1019 dbSNP
rs1455306494 1025 dbSNP
rs557331679 1026 dbSNP
rs576806398 1027 dbSNP
rs1332059967 1029 dbSNP
rs1374756259 1034 dbSNP
rs143872505 1035 dbSNP
rs1410403417 1039 dbSNP
rs1328018207 1047 dbSNP
rs752324742 1048 dbSNP
rs771304808 1051 dbSNP
rs1238514378 1052 dbSNP
rs1057482785 1053 dbSNP
rs1347151793 1061 dbSNP
rs773035273 1064 dbSNP
rs1327832539 1070 dbSNP
rs1279755796 1072 dbSNP
rs1483665283 1085 dbSNP
rs937641964 1086 dbSNP
rs1399611382 1087 dbSNP
rs1249995079 1101 dbSNP
rs927536430 1103 dbSNP
rs1029828627 1105 dbSNP
rs1476491061 1107 dbSNP
rs75846212 1111 dbSNP
rs185674796 1112 dbSNP
rs111709475 1117 dbSNP
rs1000470098 1134 dbSNP
rs902835226 1139 dbSNP
rs1309776555 1145 dbSNP
rs971804496 1150 dbSNP
rs1390626523 1155 dbSNP
rs1324020115 1158 dbSNP
rs768125810 1160 dbSNP
rs748955311 1162 dbSNP
rs962190439 1164 dbSNP
rs1018820580 1166 dbSNP
rs1302749072 1167 dbSNP
rs1342981227 1170 dbSNP
rs1009140868 1175 dbSNP
rs1273146794 1178 dbSNP
rs779492587 1183 dbSNP
rs533629172 1184 dbSNP
rs372382918 1187 dbSNP
rs1028896781 1192 dbSNP
rs1000216089 1197 dbSNP
rs566261854 1202 dbSNP
rs1013994889 1203 dbSNP
rs895591992 1221 dbSNP
rs1254037412 1230 dbSNP
rs75182241 1231 dbSNP
rs1055550727 1232 dbSNP
rs1371446882 1239 dbSNP
rs1388223116 1239 dbSNP
rs1305601434 1248 dbSNP
rs1461455400 1248 dbSNP
rs138080805 1250 dbSNP
rs1041833389 1251 dbSNP
rs1010358241 1273 dbSNP
rs895879136 1276 dbSNP
rs1385247725 1277 dbSNP
rs1376294968 1278 dbSNP
rs1057329184 1289 dbSNP
rs937140521 1299 dbSNP
rs1295562172 1302 dbSNP
rs527769721 1310 dbSNP
rs927565748 1311 dbSNP
rs1037558129 1313 dbSNP
rs1329568085 1315 dbSNP
rs1354688094 1317 dbSNP
rs1211389192 1320 dbSNP
rs1048596695 1322 dbSNP
rs1465106505 1323 dbSNP
rs1189901321 1324 dbSNP
rs1411871508 1335 dbSNP
rs940635735 1345 dbSNP
rs1427836132 1347 dbSNP
rs1188180165 1349 dbSNP
rs1369913492 1357 dbSNP
rs908541759 1358 dbSNP
rs930319046 1359 dbSNP
rs1389630902 1370 dbSNP
rs796702220 1371 dbSNP
rs539220694 1375 dbSNP
rs141705606 1377 dbSNP
rs940487401 1378 dbSNP
rs1315471008 1384 dbSNP
rs1172199547 1389 dbSNP
rs1339037647 1390 dbSNP
rs1269218768 1392 dbSNP
rs1329410614 1401 dbSNP
rs911620194 1408 dbSNP
rs1435780566 1409 dbSNP
rs1397233819 1424 dbSNP
rs987345331 1429 dbSNP
rs953168490 1430 dbSNP
rs1182326785 1442 dbSNP
rs1439566111 1444 dbSNP
rs1435693888 1445 dbSNP
rs1258216559 1453 dbSNP
rs1474207121 1457 dbSNP
rs1028928033 1459 dbSNP
rs978642147 1467 dbSNP
rs1473690824 1492 dbSNP
rs968618546 1495 dbSNP
rs1344639099 1496 dbSNP
rs1466647485 1497 dbSNP
rs1304705087 1503 dbSNP
rs1020317292 1507 dbSNP
rs1237041859 1528 dbSNP
rs1400667214 1538 dbSNP
rs1181822762 1539 dbSNP
rs1414780579 1540 dbSNP
rs755654374 1542 dbSNP
rs1010640144 1546 dbSNP
rs895925021 1551 dbSNP
rs1289371340 1554 dbSNP
rs762364 1566 dbSNP
rs1304443492 1567 dbSNP
rs1315768180 1573 dbSNP
rs1210169817 1575 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuuUCUGUCAUC---UAACAUAuc 5'
             ||:::||:|   || || |  
Target 5' gacAGGTGGTGGGCCATAGTTTcc 3'
 		11 - 34
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
STAD 0.44 0.01 0.478 0 32 Click to see details
PAAD 0.985 0.01 1.000 0.5 4 Click to see details
KICH -0.443 0.01 -0.390 0.03 25 Click to see details
ESCA 0.552 0.04 0.373 0.13 11 Click to see details
BRCA 0.169 0.06 0.103 0.18 84 Click to see details
PRAD 0.204 0.08 0.215 0.07 50 Click to see details
COAD 0.817 0.09 0.400 0.3 4 Click to see details
THCA 0.165 0.11 0.149 0.13 59 Click to see details
KIRP 0.2 0.14 0.170 0.18 32 Click to see details
CESC -0.827 0.19 -1.000 0.5 3 Click to see details
LUAD 0.253 0.21 0.336 0.14 12 Click to see details
BLCA -0.15 0.28 -0.315 0.1 18 Click to see details
CHOL 0.209 0.29 0.250 0.26 9 Click to see details
LIHC 0.078 0.3 0.092 0.26 49 Click to see details
LUSC 0.065 0.35 0.138 0.2 38 Click to see details
PCPG -0.434 0.36 -0.500 0.33 3 Click to see details
HNSC 0.036 0.41 0.036 0.41 42 Click to see details
UCEC -0.019 0.47 0.054 0.41 19 Click to see details
KIRC 0.006 0.48 0.062 0.31 68 Click to see details
KIRC 0.006 0.48 0.062 0.31 68 Click to see details
121 hsa-let-7a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038998 ARMC8 armadillo repeat containing 8 1 1
MIRT038999 SETD4 SET domain containing 4 1 1
MIRT039000 BTF3 basic transcription factor 3 1 1
MIRT039001 MIPOL1 mirror-image polydactyly 1 1 1
MIRT039002 TRIM33 tripartite motif containing 33 1 1
MIRT039003 CS citrate synthase 1 1
MIRT039004 SENP7 SUMO1/sentrin specific peptidase 7 1 1
MIRT055418 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT057681 LCOR ligand dependent nuclear receptor corepressor 2 8
MIRT061351 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT062174 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT071813 RNF11 ring finger protein 11 2 2
MIRT091374 EIF4A2 eukaryotic translation initiation factor 4A2 2 2
MIRT095107 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT098814 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT109534 KLHL15 kelch like family member 15 2 4
MIRT120263 GSK3B glycogen synthase kinase 3 beta 2 2
MIRT149839 LDLR low density lipoprotein receptor 2 6
MIRT164519 MSMO1 methylsterol monooxygenase 1 2 2
MIRT165879 CREBRF CREB3 regulatory factor 2 2
MIRT169899 HBP1 HMG-box transcription factor 1 2 4
MIRT182779 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT193466 RORA RAR related orphan receptor A 2 2
MIRT226421 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT334410 CREBZF CREB/ATF bZIP transcription factor 2 6
MIRT338286 SYF2 SYF2 pre-mRNA splicing factor 2 2
MIRT361627 TES testin LIM domain protein 2 2
MIRT406687 ZNF181 zinc finger protein 181 2 2
MIRT407768 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT449468 HAT1 histone acetyltransferase 1 2 2
MIRT467110 SRI sorcin 2 2
MIRT475099 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 6
MIRT481671 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT493061 MTFR1 mitochondrial fission regulator 1 2 2
MIRT497923 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498202 ACVR2B activin A receptor type 2B 2 2
MIRT503391 ASB11 ankyrin repeat and SOCS box containing 11 2 6
MIRT503862 UBXN2B UBX domain protein 2B 2 2
MIRT504368 ARID1B AT-rich interaction domain 1B 2 4
MIRT504991 ZNF652 zinc finger protein 652 2 2
MIRT505754 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT518102 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2 6
MIRT521930 PHF8 PHD finger protein 8 2 4
MIRT522139 NRBF2 nuclear receptor binding factor 2 2 6
MIRT522401 MYADM myeloid associated differentiation marker 2 4
MIRT523593 FZD5 frizzled class receptor 5 2 4
MIRT523944 E2F8 E2F transcription factor 8 2 4
MIRT524355 CREB1 cAMP responsive element binding protein 1 2 2
MIRT525140 ZNF256 zinc finger protein 256 2 2
MIRT527070 ABCC4 ATP binding cassette subfamily C member 4 2 2
MIRT527486 OCIAD1 OCIA domain containing 1 2 2
MIRT528129 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT530528 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT531270 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT538898 BRI3BP BRI3 binding protein 2 2
MIRT541371 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT541526 MGAT4C MGAT4 family member C 2 2
MIRT543776 RBM12B RNA binding motif protein 12B 2 4
MIRT543946 NCOA7 nuclear receptor coactivator 7 2 2
MIRT545156 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 2 2
MIRT545848 ZNF264 zinc finger protein 264 2 4
MIRT546064 VEZF1 vascular endothelial zinc finger 1 2 2
MIRT546481 SLC16A14 solute carrier family 16 member 14 2 4
MIRT551835 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT551901 ACP1 acid phosphatase 1, soluble 2 2
MIRT552490 ZNF136 zinc finger protein 136 2 2
MIRT554206 SLC35A5 solute carrier family 35 member A5 2 2
MIRT554295 SIPA1L2 signal induced proliferation associated 1 like 2 2 2
MIRT555765 PCTP phosphatidylcholine transfer protein 2 2
MIRT558315 DSG2 desmoglein 2 2 2
MIRT563147 NOLC1 nucleolar and coiled-body phosphoprotein 1 2 2
MIRT566464 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT567322 HMGB2 high mobility group box 2 2 2
MIRT567738 DLX2 distal-less homeobox 2 2 2
MIRT567892 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT570087 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT571136 TTC33 tetratricopeptide repeat domain 33 2 2
MIRT573534 MDM2 MDM2 proto-oncogene 2 2
MIRT574465 RPS16 ribosomal protein S16 2 2
MIRT574998 Phka1 phosphorylase kinase alpha 1 2 3
MIRT610202 CD99 CD99 molecule (Xg blood group) 2 4
MIRT612926 GPRIN3 GPRIN family member 3 2 2
MIRT615027 DUSP6 dual specificity phosphatase 6 2 2
MIRT617200 GREM1 gremlin 1, DAN family BMP antagonist 2 2
MIRT628720 ZNF585A zinc finger protein 585A 2 2
MIRT641491 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT641663 PAPOLG poly(A) polymerase gamma 2 2
MIRT642216 RUVBL2 RuvB like AAA ATPase 2 2 2
MIRT654589 PURA purine rich element binding protein A 2 2
MIRT656136 MSH6 mutS homolog 6 2 2
MIRT656899 KIAA2018 upstream transcription factor family member 3 2 2
MIRT660136 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT660861 AFAP1 actin filament associated protein 1 2 2
MIRT676849 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 3
MIRT681479 DIP2A disco interacting protein 2 homolog A 2 2
MIRT682259 RS1 retinoschisin 1 2 2
MIRT685602 MYOM2 myomesin 2 2 2
MIRT686943 SFT2D3 SFT2 domain containing 3 2 2
MIRT694302 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT694407 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT697280 ZNF800 zinc finger protein 800 2 2
MIRT698414 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT698989 SPAG9 sperm associated antigen 9 2 2
MIRT699766 SEMA4D semaphorin 4D 2 2
MIRT699928 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT702113 MBNL1 muscleblind like splicing regulator 1 2 2
MIRT702373 KLF10 Kruppel like factor 10 2 2
MIRT702646 ITGA3 integrin subunit alpha 3 2 2
MIRT705713 ANAPC16 anaphase promoting complex subunit 16 2 2
MIRT717925 ZNF546 zinc finger protein 546 2 2
MIRT720839 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT725033 NDUFAF7 NADH:ubiquinone oxidoreductase complex assembly factor 7 2 2
MIRT731448 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 1 1
MIRT733217 CCNG1 cyclin G1 2 0
MIRT734887 LIN28B lin-28 homolog B 1 0
MIRT735276 HMGA2 high mobility group AT-hook 2 2 0
MIRT735727 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 3 0
MIRT736087 RCVRN recoverin 1 0
MIRT736088 RHO rhodopsin 1 0
MIRT736103 TLR7 toll like receptor 7 1 0
MIRT736607 TPO thyroid peroxidase 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
let-7a Caudatin NULL 21633059 Quantitative real-time PCR gastric carcinoma cell lines 23708208 2013 up-regualted
let-7a XMD8-92 NULL 46843772 Microarray pancreatic ductal adenocarcinoma cell 24880079 2014 up-regulated
let-7a Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 down-regulated
let-7a Hydroxamic acid HDACi LAQ824 NULL NULL Northern blot breast cancer cell line SKBr3 16452180 2006 down-regulated
let-7a Trichostatin A (TSA) NULL 444732 Microarray human pancreatic cancer cell line BxPC-3 19112422 2009 down-regulated
let-7a 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
let-7a Etoposide approved 36462 Microarray Normal human fibroblasts (AG01522) 19633716 2009 down-regulated
let-7a Etoposide approved 36462 Quantitative real-time PCR Normal human fibroblasts (AG01522) 19633716 2009 down-regulated
let-7a Polylysine NULL 162282 Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
let-7a Trypaflavine NULL NULL Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
let-7a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
let-7a Enoxacin approved 3229 Northern blot HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
let-7a Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR MCF-7 human mammary cancer cell line 21368581 2011 up-regulated
let-7a 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 up-regulated
let-7a Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
let-7a CDF(analogues of curcumin) NULL NULL Quantitative real-time PCR pancreatic cancer cells 22108826 2012 up-regulated
let-7a Marine fungal metabolite 1386A NULL NULL Microarray MCF-7 breast cancer cells. 22159329 2012 down-regulated
let-7a Curcumin NULL 969516 Quantitative real-time PCR esophageal cancer cells 22363450 2012 up-regulated
let-7a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 up-regulated
let-7a Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
let-7a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 down-regulated
let-7a Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 up-regulated
let-7a Budesonide approved 5281004 Microarray neonatal mice lung 20145010 2010 down-regulated
let-7a Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice lung 20145010 2010 up-regulated
let-7a Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
let-7a Dexamethasone approved 5743 Quantitative real-time PCR primary rat thymocytes 20847043 2010 down-regulated
let-7a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
let-7a Hydroxychloroquine approved 3652 Quantitative real-time PCR mesangial cells 24121037 2013 down-regualted
let-7a Prednisone approved 5865 Quantitative real-time PCR mesangial cells 24121037 2013 down-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-let-7a-3p Gemcitabine 60750 NSC613327 approved resistant High Cholangiocarcinoma cell line (HuCCT1, HuH28)
hsa-let-7a-3p Docetaxel 148124 NSC628503 approved sensitive High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-let-7a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-let-7a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-let-7a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-let-7a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-let-7a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-let-7a-3p Fluorouracil 3385 NSC19893 approved sensitive cell line (HCT15)
hsa-let-7a-3p 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-let-7a-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-let-7a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-let-7a-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-let-7a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

Error report submission