miRTarBase - #MIRT039003


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pre-miRNA Information
pre-miRNA hsa-let-7a-1   
Genomic Coordinates chr9: 94175957 - 94176036
Synonyms LET7A1, MIRNLET7A1, let-7a-1, MIRLET7A1
Description Homo sapiens let-7a-1 stem-loop
Comment let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-let-7a-3   
Genomic Coordinates chr22: 46112749 - 46112822
Synonyms LET7A3, MIRNLET7A3, let-7a-3, MIRLET7A3
Description Homo sapiens let-7a-3 stem-loop
Comment let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-let-7a-3p
Sequence 57| CUAUACAAUCUACUGUCUUUC |77
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 9 + 94176017 29233923 MiREDiBase
A-to-I 5 22 + 46112804 29233923 MiREDiBase
A-to-I 12 22 + 46112811 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs972845958 1 dbSNP
rs781681931 2 dbSNP
rs748585376 3 dbSNP
rs779353569 6 dbSNP
rs1198423693 8 dbSNP
rs970921980 8 dbSNP
rs372596018 9 dbSNP
rs770208205 10 dbSNP
rs1453867589 11 dbSNP
rs1399588338 15 dbSNP
rs1219969167 16 dbSNP
rs1265084977 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CS   
Synonyms -
Description citrate synthase
Transcript NM_004077   
Expression
Putative miRNA Targets on CS
3'UTR of CS
(miRNA target sites are highlighted)		 
>CS|NM_004077|3'UTR
   1 AACTGGAGACTGGGTGAAAGTGACTACCAGAAAGTGAGGAAGCCTAAATAAAAAGTATACTTTTGTTTCAGGGGGCCTTT
  81 AAAGACTTAAGATTAAATTATATCTGAGGCACTGATAATATGTTTGAGGTTAAAATATAAATTAAGACTTTAAAAGATGA
 161 AAAATGGTCCCTTCTTCCCTAATCAGCTCCCTTCCCCTGCCTGGTATGAGTTGCCCATCATACGCATGGTCCTGGAGGAT
 241 GACCAGGACTAATGCATGTGGTATGAGTAGGTTTGGCCCCCTCACTATCTCTAGAGTGAGAATCTGGCTCCTGTTTCCAT
 321 GGGTCAAAGCCGGTTGCAGAGAATCTGTAGTCACTTTGGAGCTTTAGCTTCTCTGCCAAGCCCTCAATAAGCCAGCAAAC
 401 CAGGACTCTGCCCCTTCTGTTTCCATAGGAATCATGTTGGATAGTCAGCTGTACCAAGCCCCTTGGCCCTCTCCCATGCA
 481 CACAAACACCTCCTAGCAAGACCTGTTGGTTAGCTGGACATGCTTTGGCAATTTTTTTATACTACCAAGTGACCATAAAG
 561 GCATGGCATTTGTTGTGACTGGCACCCAATGTTTGATTTTTTTTTTAAAACTATCCAATTAAAATTAAGGTCTGGGAGTG
 641 TTCTGTTTCCCATTACTTTAATACTCACCTCCTCCCAGACTTTCTACACCTGTTGCACCTCAGGCAGAGGATGTTCTGGA
 721 CCTCCCCCTCTTGGTCCCTACTAGAGACCTCTCAACAGATCTGTGGGCCCAGTCATTGGGTTTTATCAGTGCTTAATGTG
 801 AACTAAGTTTTTTACTTCCACAGAATACAAGCCACTACCTTCTGACCTCCCCACCCCCCACCAACCCCCATCTTTTAATA
 881 TGCTGTGGGGCATAGAACTCCGGAATGACCAGCATGATATTTTCAGAGTCTTGTCCCCGGGGTATTAGCACCTCTTTTTG
 961 AACAGGGAATTGATTCAAGATTGGACATGGTCTCCTCTGATTATCAGGTACTGGGGCTGAGGGCATTAAAAATAGTAAGC
1041 CTCCCTCCTCGTCCCCTGCCTCAAGAAATTGCCTCCTTATTTATCAACATCTTTTTCCTCCCTTTCCCTGAGAGCTCACA
1121 GTACAATGTTTCAGAAGCCCCATTTGCACAGGTTTTCAGCAACTCAGAATGCTCTACTTCTTTTTCTTTGAGAAAGGATT
1201 AAGATACACTCCTGCTGTGCCCCCATCTTTCCTCCAAACTCCTGCCTGTGTTTGTGTGGATACCCAGTCCCAGAACCACA
1281 CTGTTGAGTTGGACACACTGTAAACCCCTGGGTAACTGTCAAGTCATGATGGAGACTTCAGGTTGTTCTGTATAAAATGC
1361 AAAATAAATGTTTTTATTAACAATGAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuUUCUG----UCAUCUA-ACAUAUc 5'
            :||||    :|| | | |||||| 
Target 5' tgGAGACTTCAGGTTGTTCTGTATAa 3'
 1330 - 1355 125.00 -10.45
2 
miRNA  3' cuuUCUGUCAUCUAACAUAUc 5'
             ||: |  | :||| ||| 
Target 5' catAGGAATCATGTTGGATAg 3'
 424 - 444 118.00 -5.30
3 
miRNA  3' cuuuCUGUCAUCUAACAUAUc 5'
              | | || | ||||:|: 
Target 5' tcctGCCTGT-GTTTGTGTGg 3'
 1240 - 1259 116.00 -8.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN19667967 13 COSMIC
COSN1577367 254 COSMIC
COSN5324372 349 COSMIC
COSN16490825 446 COSMIC
COSN1577365 541 COSMIC
COSN20077582 606 COSMIC
COSN17644384 1180 COSMIC
COSN31485819 1186 COSMIC
COSN21473383 1190 COSMIC
COSN1577363 1202 COSMIC
COSN30580388 1206 COSMIC
COSN26553688 1211 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1328598382 4 dbSNP
rs1462430859 9 dbSNP
rs753151165 10 dbSNP
rs374097567 12 dbSNP
rs28576579 15 dbSNP
rs760071962 16 dbSNP
rs754399171 23 dbSNP
rs766868394 27 dbSNP
rs1433458770 28 dbSNP
rs1300578045 30 dbSNP
rs1467247409 31 dbSNP
rs1254964952 41 dbSNP
rs1345918807 42 dbSNP
rs761396136 43 dbSNP
rs892994429 63 dbSNP
rs530474676 65 dbSNP
rs1054262362 71 dbSNP
rs1370041798 72 dbSNP
rs942624600 74 dbSNP
rs911124214 75 dbSNP
rs1466844720 90 dbSNP
rs1208725872 91 dbSNP
rs1288061736 121 dbSNP
rs1447452183 127 dbSNP
rs1391887446 128 dbSNP
rs1163942580 137 dbSNP
rs1475445694 138 dbSNP
rs765892108 142 dbSNP
rs1050490168 151 dbSNP
rs1369989695 153 dbSNP
rs1179486297 154 dbSNP
rs1394900217 156 dbSNP
rs570364351 158 dbSNP
rs1418462013 164 dbSNP
rs1160762504 172 dbSNP
rs1409354127 177 dbSNP
rs1400594520 181 dbSNP
rs1316341882 191 dbSNP
rs923257743 195 dbSNP
rs1441967244 197 dbSNP
rs1325472313 198 dbSNP
rs761721390 199 dbSNP
rs972576271 213 dbSNP
rs548595549 214 dbSNP
rs940749848 219 dbSNP
rs530355595 223 dbSNP
rs1467283029 224 dbSNP
rs1223098244 228 dbSNP
rs1281591003 231 dbSNP
rs909413145 234 dbSNP
rs1213990165 235 dbSNP
rs1252002107 240 dbSNP
rs984904118 241 dbSNP
rs958985421 244 dbSNP
rs559673010 251 dbSNP
rs1238901503 253 dbSNP
rs981680965 255 dbSNP
rs971476117 258 dbSNP
rs1019927831 266 dbSNP
rs1010004409 267 dbSNP
rs1448437087 275 dbSNP
rs1392562310 277 dbSNP
rs151185868 279 dbSNP
rs1330667291 284 dbSNP
rs760239291 289 dbSNP
rs1441444777 304 dbSNP
rs1277702023 310 dbSNP
rs1006726837 313 dbSNP
rs889741916 316 dbSNP
rs1271940990 319 dbSNP
rs1332248604 323 dbSNP
rs1197156753 324 dbSNP
rs1437606548 331 dbSNP
rs532516469 332 dbSNP
rs564999875 336 dbSNP
rs901853008 337 dbSNP
rs75167523 344 dbSNP
rs1156614635 347 dbSNP
rs1187353455 349 dbSNP
rs79563232 354 dbSNP
rs940800828 357 dbSNP
rs1168683938 362 dbSNP
rs909297026 377 dbSNP
rs1409166610 383 dbSNP
rs1326528710 397 dbSNP
rs1452599253 405 dbSNP
rs937516752 407 dbSNP
rs984956273 407 dbSNP
rs768428170 410 dbSNP
rs927442761 417 dbSNP
rs1338280554 422 dbSNP
rs541148444 425 dbSNP
rs1282866233 426 dbSNP
rs1486298982 429 dbSNP
rs188988246 439 dbSNP
rs1204958801 451 dbSNP
rs1194243217 453 dbSNP
rs1372721298 456 dbSNP
rs1474524238 459 dbSNP
rs1165959468 462 dbSNP
rs971645936 465 dbSNP
rs1312195297 490 dbSNP
rs1373151628 501 dbSNP
rs1383429198 511 dbSNP
rs369187944 514 dbSNP
rs1325523692 519 dbSNP
rs1020401680 523 dbSNP
rs1352025917 539 dbSNP
rs1306152899 540 dbSNP
rs1288854267 542 dbSNP
rs1349013011 562 dbSNP
rs1232756918 595 dbSNP
rs1368061979 597 dbSNP
rs1487096227 605 dbSNP
rs1302098723 606 dbSNP
rs56927826 607 dbSNP
rs576026053 607 dbSNP
rs796223137 607 dbSNP
rs957149430 607 dbSNP
rs1006610506 613 dbSNP
rs1454540328 619 dbSNP
rs1172718393 629 dbSNP
rs1393200803 630 dbSNP
rs556878372 631 dbSNP
rs11171787 632 dbSNP
rs148677822 645 dbSNP
rs1436686982 657 dbSNP
rs1332508818 664 dbSNP
rs1455247375 672 dbSNP
rs563786800 684 dbSNP
rs889636008 687 dbSNP
rs1383591880 694 dbSNP
rs1380212754 703 dbSNP
rs1315921402 706 dbSNP
rs1327500062 707 dbSNP
rs1381502303 712 dbSNP
rs1440650183 713 dbSNP
rs574601731 714 dbSNP
rs552913125 721 dbSNP
rs1240357612 727 dbSNP
rs1160320181 728 dbSNP
rs1215849070 734 dbSNP
rs771015254 741 dbSNP
rs1432823259 743 dbSNP
rs1468152862 745 dbSNP
rs1192808797 748 dbSNP
rs1264942993 758 dbSNP
rs534781159 769 dbSNP
rs998538827 773 dbSNP
rs1283917196 776 dbSNP
rs1362784671 778 dbSNP
rs1394507035 788 dbSNP
rs1174394885 795 dbSNP
rs1479112313 814 dbSNP
rs185573267 815 dbSNP
rs1038352762 823 dbSNP
rs1192906494 827 dbSNP
rs897050763 827 dbSNP
rs939995644 828 dbSNP
rs1265800063 831 dbSNP
rs940686139 831 dbSNP
rs1306896504 839 dbSNP
rs1334445334 854 dbSNP
rs1209304782 858 dbSNP
rs887742842 859 dbSNP
rs1049134652 860 dbSNP
rs1212035261 877 dbSNP
rs1219343551 881 dbSNP
rs937405556 888 dbSNP
rs1481491711 895 dbSNP
rs558636513 901 dbSNP
rs374647928 902 dbSNP
rs1226250643 907 dbSNP
rs1189467759 915 dbSNP
rs1417919820 920 dbSNP
rs1460630449 928 dbSNP
rs1162250611 933 dbSNP
rs1356700847 937 dbSNP
rs543842017 938 dbSNP
rs1299834894 939 dbSNP
rs1412836808 944 dbSNP
rs1374816674 951 dbSNP
rs1417110894 954 dbSNP
rs569656349 966 dbSNP
rs1354869745 974 dbSNP
rs1045890573 979 dbSNP
rs1416299929 981 dbSNP
rs950375568 990 dbSNP
rs1308244765 993 dbSNP
rs1204967478 997 dbSNP
rs1167487446 999 dbSNP
rs1250498905 999 dbSNP
rs913483430 1007 dbSNP
rs12314191 1008 dbSNP
rs1257683859 1010 dbSNP
rs1474585902 1011 dbSNP
rs1426164384 1015 dbSNP
rs1421210807 1033 dbSNP
rs1186309863 1050 dbSNP
rs1428703399 1051 dbSNP
rs1170218398 1053 dbSNP
rs1485611835 1061 dbSNP
rs1388684517 1064 dbSNP
rs1437168957 1067 dbSNP
rs1398000283 1071 dbSNP
rs530350752 1088 dbSNP
rs1445933248 1091 dbSNP
rs1290643866 1092 dbSNP
rs1210186585 1093 dbSNP
rs1443579622 1099 dbSNP
rs777468623 1100 dbSNP
rs1362962182 1107 dbSNP
rs1270317606 1111 dbSNP
rs758641229 1112 dbSNP
rs1294628641 1115 dbSNP
rs566330694 1136 dbSNP
rs985220122 1143 dbSNP
rs1175205756 1147 dbSNP
rs1481504935 1151 dbSNP
rs879096532 1163 dbSNP
rs1207450545 1165 dbSNP
rs1243295511 1166 dbSNP
rs1260036372 1172 dbSNP
rs1213438142 1173 dbSNP
rs1318485097 1174 dbSNP
rs1185541771 1181 dbSNP
rs1388780220 1183 dbSNP
rs1233345976 1186 dbSNP
rs1029933424 1189 dbSNP
rs1309612902 1192 dbSNP
rs547684776 1194 dbSNP
rs1368250891 1195 dbSNP
rs1305009654 1197 dbSNP
rs193099996 1206 dbSNP
rs1384921909 1209 dbSNP
rs1345827403 1212 dbSNP
rs1287607617 1214 dbSNP
rs1015472009 1215 dbSNP
rs1271413817 1223 dbSNP
rs565085051 1224 dbSNP
rs768361500 1225 dbSNP
rs1430358171 1237 dbSNP
rs1318767215 1240 dbSNP
rs762717610 1242 dbSNP
rs1452819108 1247 dbSNP
rs1373393449 1248 dbSNP
rs1235365542 1249 dbSNP
rs1442835327 1260 dbSNP
rs543501673 1261 dbSNP
rs1005384502 1268 dbSNP
rs531629089 1273 dbSNP
rs1217386985 1277 dbSNP
rs1285795611 1282 dbSNP
rs887795100 1283 dbSNP
rs1214707081 1289 dbSNP
rs1245832887 1300 dbSNP
rs1466317646 1305 dbSNP
rs1194692383 1316 dbSNP
rs1252713529 1319 dbSNP
rs55781726 1329 dbSNP
rs1384700755 1334 dbSNP
rs1477347290 1336 dbSNP
rs1408876541 1339 dbSNP
rs1400204161 1341 dbSNP
rs1049025373 1351 dbSNP
rs1402777129 1357 dbSNP
rs1002056867 1361 dbSNP
rs750687320 1362 dbSNP
rs905931189 1363 dbSNP
rs1046362567 1366 dbSNP
rs1475116201 1367 dbSNP
rs1281206424 1371 dbSNP
rs1373881210 1376 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site CDS
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA -0.203 0.06 -0.106 0.21 59 Click to see details
KIRP -0.253 0.08 -0.246 0.09 32 Click to see details
LIHC -0.178 0.11 -0.215 0.07 49 Click to see details
UCEC 0.266 0.14 0.211 0.19 19 Click to see details
STAD -0.198 0.14 -0.229 0.1 32 Click to see details
BRCA -0.07 0.26 -0.042 0.35 84 Click to see details
LUAD -0.19 0.28 -0.259 0.21 12 Click to see details
KIRC -0.065 0.3 -0.045 0.36 68 Click to see details
ESCA -0.163 0.32 -0.073 0.42 11 Click to see details
COAD 0.347 0.33 0.000 0.5 4 Click to see details
LUSC 0.07 0.34 0.025 0.44 38 Click to see details
CHOL 0.152 0.35 0.267 0.24 9 Click to see details
PAAD -0.231 0.38 0.200 0.4 4 Click to see details
PRAD 0.029 0.42 -0.012 0.47 50 Click to see details
CESC -0.23 0.43 -0.500 0.33 3 Click to see details
HNSC 0.02 0.45 0.007 0.48 42 Click to see details
BLCA -0.019 0.47 -0.069 0.39 18 Click to see details
KICH 0.014 0.47 0.042 0.42 25 Click to see details
PCPG 0.022 0.49 0.500 0.33 3 Click to see details
PCPG 0.022 0.49 0.500 0.33 3 Click to see details
121 hsa-let-7a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038998 ARMC8 armadillo repeat containing 8 1 1
MIRT038999 SETD4 SET domain containing 4 1 1
MIRT039000 BTF3 basic transcription factor 3 1 1
MIRT039001 MIPOL1 mirror-image polydactyly 1 1 1
MIRT039002 TRIM33 tripartite motif containing 33 1 1
MIRT039003 CS citrate synthase 1 1
MIRT039004 SENP7 SUMO1/sentrin specific peptidase 7 1 1
MIRT055418 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT057681 LCOR ligand dependent nuclear receptor corepressor 2 8
MIRT061351 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT062174 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT071813 RNF11 ring finger protein 11 2 2
MIRT091374 EIF4A2 eukaryotic translation initiation factor 4A2 2 2
MIRT095107 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT098814 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT109534 KLHL15 kelch like family member 15 2 4
MIRT120263 GSK3B glycogen synthase kinase 3 beta 2 2
MIRT149839 LDLR low density lipoprotein receptor 2 6
MIRT164519 MSMO1 methylsterol monooxygenase 1 2 2
MIRT165879 CREBRF CREB3 regulatory factor 2 2
MIRT169899 HBP1 HMG-box transcription factor 1 2 4
MIRT182779 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT193466 RORA RAR related orphan receptor A 2 2
MIRT226421 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT334410 CREBZF CREB/ATF bZIP transcription factor 2 6
MIRT338286 SYF2 SYF2 pre-mRNA splicing factor 2 2
MIRT361627 TES testin LIM domain protein 2 2
MIRT406687 ZNF181 zinc finger protein 181 2 2
MIRT407768 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT449468 HAT1 histone acetyltransferase 1 2 2
MIRT467110 SRI sorcin 2 2
MIRT475099 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 6
MIRT481671 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT493061 MTFR1 mitochondrial fission regulator 1 2 2
MIRT497923 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498202 ACVR2B activin A receptor type 2B 2 2
MIRT503391 ASB11 ankyrin repeat and SOCS box containing 11 2 6
MIRT503862 UBXN2B UBX domain protein 2B 2 2
MIRT504368 ARID1B AT-rich interaction domain 1B 2 4
MIRT504991 ZNF652 zinc finger protein 652 2 2
MIRT505754 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT518102 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2 6
MIRT521930 PHF8 PHD finger protein 8 2 4
MIRT522139 NRBF2 nuclear receptor binding factor 2 2 6
MIRT522401 MYADM myeloid associated differentiation marker 2 4
MIRT523593 FZD5 frizzled class receptor 5 2 4
MIRT523944 E2F8 E2F transcription factor 8 2 4
MIRT524355 CREB1 cAMP responsive element binding protein 1 2 2
MIRT525140 ZNF256 zinc finger protein 256 2 2
MIRT527070 ABCC4 ATP binding cassette subfamily C member 4 2 2
MIRT527486 OCIAD1 OCIA domain containing 1 2 2
MIRT528129 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT530528 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT531270 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT538898 BRI3BP BRI3 binding protein 2 2
MIRT541371 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT541526 MGAT4C MGAT4 family member C 2 2
MIRT543776 RBM12B RNA binding motif protein 12B 2 4
MIRT543946 NCOA7 nuclear receptor coactivator 7 2 2
MIRT545156 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 2 2
MIRT545848 ZNF264 zinc finger protein 264 2 4
MIRT546064 VEZF1 vascular endothelial zinc finger 1 2 2
MIRT546481 SLC16A14 solute carrier family 16 member 14 2 4
MIRT551835 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT551901 ACP1 acid phosphatase 1, soluble 2 2
MIRT552490 ZNF136 zinc finger protein 136 2 2
MIRT554206 SLC35A5 solute carrier family 35 member A5 2 2
MIRT554295 SIPA1L2 signal induced proliferation associated 1 like 2 2 2
MIRT555765 PCTP phosphatidylcholine transfer protein 2 2
MIRT558315 DSG2 desmoglein 2 2 2
MIRT563147 NOLC1 nucleolar and coiled-body phosphoprotein 1 2 2
MIRT566464 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT567322 HMGB2 high mobility group box 2 2 2
MIRT567738 DLX2 distal-less homeobox 2 2 2
MIRT567892 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT570087 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT571136 TTC33 tetratricopeptide repeat domain 33 2 2
MIRT573534 MDM2 MDM2 proto-oncogene 2 2
MIRT574465 RPS16 ribosomal protein S16 2 2
MIRT574998 Phka1 phosphorylase kinase alpha 1 2 3
MIRT610202 CD99 CD99 molecule (Xg blood group) 2 4
MIRT612926 GPRIN3 GPRIN family member 3 2 2
MIRT615027 DUSP6 dual specificity phosphatase 6 2 2
MIRT617200 GREM1 gremlin 1, DAN family BMP antagonist 2 2
MIRT628720 ZNF585A zinc finger protein 585A 2 2
MIRT641491 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT641663 PAPOLG poly(A) polymerase gamma 2 2
MIRT642216 RUVBL2 RuvB like AAA ATPase 2 2 2
MIRT654589 PURA purine rich element binding protein A 2 2
MIRT656136 MSH6 mutS homolog 6 2 2
MIRT656899 KIAA2018 upstream transcription factor family member 3 2 2
MIRT660136 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT660861 AFAP1 actin filament associated protein 1 2 2
MIRT676849 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 3
MIRT681479 DIP2A disco interacting protein 2 homolog A 2 2
MIRT682259 RS1 retinoschisin 1 2 2
MIRT685602 MYOM2 myomesin 2 2 2
MIRT686943 SFT2D3 SFT2 domain containing 3 2 2
MIRT694302 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT694407 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT697280 ZNF800 zinc finger protein 800 2 2
MIRT698414 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT698989 SPAG9 sperm associated antigen 9 2 2
MIRT699766 SEMA4D semaphorin 4D 2 2
MIRT699928 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT702113 MBNL1 muscleblind like splicing regulator 1 2 2
MIRT702373 KLF10 Kruppel like factor 10 2 2
MIRT702646 ITGA3 integrin subunit alpha 3 2 2
MIRT705713 ANAPC16 anaphase promoting complex subunit 16 2 2
MIRT717925 ZNF546 zinc finger protein 546 2 2
MIRT720839 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT725033 NDUFAF7 NADH:ubiquinone oxidoreductase complex assembly factor 7 2 2
MIRT731448 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 1 1
MIRT733217 CCNG1 cyclin G1 2 0
MIRT734887 LIN28B lin-28 homolog B 1 0
MIRT735276 HMGA2 high mobility group AT-hook 2 2 0
MIRT735727 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 3 0
MIRT736087 RCVRN recoverin 1 0
MIRT736088 RHO rhodopsin 1 0
MIRT736103 TLR7 toll like receptor 7 1 0
MIRT736607 TPO thyroid peroxidase 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
let-7a Caudatin NULL 21633059 Quantitative real-time PCR gastric carcinoma cell lines 23708208 2013 up-regualted
let-7a XMD8-92 NULL 46843772 Microarray pancreatic ductal adenocarcinoma cell 24880079 2014 up-regulated
let-7a Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 down-regulated
let-7a Hydroxamic acid HDACi LAQ824 NULL NULL Northern blot breast cancer cell line SKBr3 16452180 2006 down-regulated
let-7a Trichostatin A (TSA) NULL 444732 Microarray human pancreatic cancer cell line BxPC-3 19112422 2009 down-regulated
let-7a 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
let-7a Etoposide approved 36462 Microarray Normal human fibroblasts (AG01522) 19633716 2009 down-regulated
let-7a Etoposide approved 36462 Quantitative real-time PCR Normal human fibroblasts (AG01522) 19633716 2009 down-regulated
let-7a Polylysine NULL 162282 Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
let-7a Trypaflavine NULL NULL Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
let-7a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
let-7a Enoxacin approved 3229 Northern blot HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
let-7a Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR MCF-7 human mammary cancer cell line 21368581 2011 up-regulated
let-7a 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 up-regulated
let-7a Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
let-7a CDF(analogues of curcumin) NULL NULL Quantitative real-time PCR pancreatic cancer cells 22108826 2012 up-regulated
let-7a Marine fungal metabolite 1386A NULL NULL Microarray MCF-7 breast cancer cells. 22159329 2012 down-regulated
let-7a Curcumin NULL 969516 Quantitative real-time PCR esophageal cancer cells 22363450 2012 up-regulated
let-7a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 up-regulated
let-7a Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
let-7a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 down-regulated
let-7a Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 up-regulated
let-7a Budesonide approved 5281004 Microarray neonatal mice lung 20145010 2010 down-regulated
let-7a Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice lung 20145010 2010 up-regulated
let-7a Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
let-7a Dexamethasone approved 5743 Quantitative real-time PCR primary rat thymocytes 20847043 2010 down-regulated
let-7a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
let-7a Hydroxychloroquine approved 3652 Quantitative real-time PCR mesangial cells 24121037 2013 down-regualted
let-7a Prednisone approved 5865 Quantitative real-time PCR mesangial cells 24121037 2013 down-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-let-7a-3p Gemcitabine 60750 NSC613327 approved resistant High Cholangiocarcinoma cell line (HuCCT1, HuH28)
hsa-let-7a-3p Docetaxel 148124 NSC628503 approved sensitive High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-let-7a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-let-7a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-let-7a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-let-7a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-let-7a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-let-7a-3p Fluorouracil 3385 NSC19893 approved sensitive cell line (HCT15)
hsa-let-7a-3p 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-let-7a-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-let-7a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-let-7a-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-let-7a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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