miRTarBase - #MIRT039243


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pre-miRNA Information
pre-miRNA hsa-mir-454   
Genomic Coordinates chr17: 59137758 - 59137872
Synonyms MIRN454, hsa-mir-454, MIR454
Description Homo sapiens miR-454 stem-loop
Comment The mature miRNA sequences were named miR-454-5p and miR-454-3p in .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-454-3p
Sequence 64| UAGUGCAAUAUUGCUUAUAGGGU |86
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30529712 20 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1391884708 2 dbSNP
rs772555392 4 dbSNP
rs555225543 7 dbSNP
rs1450965019 11 dbSNP
rs779514158 12 dbSNP
rs771457463 18 dbSNP
rs377123764 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol STK38   
Synonyms NDR, NDR1
Description serine/threonine kinase 38
Transcript NM_007271   
Expression
Putative miRNA Targets on STK38
3'UTR of STK38
(miRNA target sites are highlighted)		 
>STK38|NM_007271|3'UTR
   1 TACTCTTGCCACGGAATCCTATGTGGAGCAGAGTTCTTTGTATAACATCATGCTTTTCCTCTCACACTCTTGAAGAGCTT
  81 CCAAGAAGTTGATGGAACCCACCAATATGTCATAGTAAAGTCTCCTGAAATGTGGTAGTAAGAGGATTTTCTTCCATAAT
 161 GCATCTGAAAAACTGTAAACAAAGACAACCATTTCTACTACGTCGGCCATAAACAGCTATCCTGCTTTGGAAGAGAAGCA
 241 TCATGAGCCAATTTGATAGGTGTTTTAAAAATAACTTGAGTTTTCCTAAGTTCATCAGAATGAAGGGGAAAAACAGCCAT
 321 CATCCAACATTATTGAGATTGTCGTGTATAGTCATCGAATATCAGCCAGTTCCTGTAATTTTGTGACACGCTCTCTGCCA
 401 AGCCCACCAAGTATTTCCTTTATAGCTAAAAGTTCCATAGTACTAAGGAAATAAAGCAATAAAGACAGTCTCAGCAGCCA
 481 GGATTCTGGCTGAAGGAAATGATCCGCCACCCTGAGGGTGGTGATGGTAGTTTCTACCCATACCTCAGCCTCAGGCGAGT
 561 GGCTTATAGCCTCCATTCATGGTGCACTTTATTTATGGTACTAAGATAAAGACTGTCAATCCATTGATTTATCTCCTCCT
 641 GTCCCCCATCTAAAATACCCATGCTGCTTTTCTGAGTGTTGATGGGGGTTACCAGCTTGATCCACTGTTGCTCTTAGAAG
 721 GCCCAGAAAGTCTTTGGGCATTGCCAAGAAATCCCGGATTATGTGGAAAACCCTCACTTTCTCTTCACGGCTGTACCAGA
 801 AAATCCCTAAGACAGATCTTGCCGTGGACTAGCAATACCTGCAAGTGCTGCCAATGGGAACTCAATTTATTCCTGGGAAC
 881 CTAACGAGGAGAGCCCAGGCCTAGGCAGGAGGCCTGGAACCCTCTTGGCTAAGGTGCTGTTCCTGTTCCTGCAAGGTCTC
 961 CAGAACCCCTTTGGAAATGGTGAAGGAACCAGCCCAATAGAAGTACAGAGCCAGCTGACAAGTCCTTGTAAAGCTCACTC
1041 CTCAGTCCTTGGCACAGCCATGTTTTGTCTTCTCTCTTGGTATTTCTTCTCTCCCAACTTTAGCCATTTTGCCTTGGAAT
1121 CATGATTACAATTTTTTCCTTTGCAGATGCCTTCCTGGGGGATACTCCTCCCCACCCTAAAGGGTCGCCTGCAACTTAGG
1201 CGGATTGGGTCTCTCTGCTGTGGCGTTCTCTCTTGAGAGACCCTCTGAATTTTAGCACAAAGTGCCTTCTGTTTCACAGC
1281 TGCCACCACCTTTAGAGGAATTTCGTCAGAAAAATGTGGAGGCTCCATATTAATGCATTATTTTTTAAAAAGTTTTGATA
1361 ACTCTTAAAGCATCATTTGCACCTATGTGGGAACTTTGCCTGTTGCAAAGTATTGTGGCCGAGCTGCAGCTGGGAGCCTG
1441 CTTTCTGCCAGTCTTGAGGTTCTGAAGATCAGCTTTGAAAGGAAAGTATGTCCTAGCTTAGCCATTCAGAAGAGAAAAAT
1521 GGAATATCAGAGTTACAGTTGTCAGTGAAACTACTTTGGATTTTAACCTCTTAGAGGAAGAAAAAAGGTTAGGGAAGTGT
1601 CAACTCTGGATGAAGGTGATGTGTTTGCCTCTCAGTCTTTCATTCATAGCCTGCTAGTGAAAAGGAAGTAAATGAGATTC
1681 TTTTGTGTGACTTTGTAGTCTCTTTGTATTACCAAATAGTTGGGGTGTTGACTCCTGTGTGTTTTGCAAGAATGTGTGGT
1761 AAGCCTGGGTAAAGAGAAGGAACTGCGGTGTTGGGAGAGTCTTTGTGTTGGGGAGTGGCAGGGGATGATTTGTTTCAGGG
1841 GAAAATGCCCACATTTTAACTTTTAAACTTCTGAATAAACTGTGTAAAAACAGTAGTGGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugGGAUAUUCGU--UAUAACGUGau 5'
            |:|| |||||  || ||||||  
Target 5' ctCTTA-AAGCATCAT-TTGCACct 3'
 1362 - 1384 145.00 -13.20
2 
miRNA  3' ugGGAUAUU---CGU---UAUAACGUGAu 5'
            |:||||:    ||   ||: |||||| 
Target 5' ggCTTATAGCCTCCATTCATGGTGCACTt 3'
 561 - 589 129.00 -12.70
3 
miRNA  3' uggGAUAUUCGUUAUAACGUGAu 5'
             ||  |  || |:|||| || 
Target 5' cagCTTGATCCACTGTTGCTCTt 3'
 693 - 715 124.00 -8.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30142361 13 COSMIC
COSN22710357 18 COSMIC
COSN30580500 29 COSMIC
COSN30101156 59 COSMIC
COSN29468659 65 COSMIC
COSN30154607 72 COSMIC
COSN19707488 85 COSMIC
COSN20049606 95 COSMIC
COSN31538090 95 COSMIC
COSN31552691 120 COSMIC
COSN30107609 259 COSMIC
COSN6319542 277 COSMIC
COSN23414371 344 COSMIC
COSN17181711 404 COSMIC
COSN4955239 505 COSMIC
COSN26562522 601 COSMIC
COSN31539045 643 COSMIC
COSN32193425 863 COSMIC
COSN20586740 950 COSMIC
COSN22599775 1114 COSMIC
COSN31577465 1176 COSMIC
COSN31603486 1186 COSMIC
COSN28833009 1243 COSMIC
COSN30543301 1397 COSMIC
COSN17078247 1430 COSMIC
COSN31489299 1507 COSMIC
COSN28648780 1554 COSMIC
COSN20102778 1581 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1223723726 3 dbSNP
rs373678730 4 dbSNP
rs935321585 10 dbSNP
rs923887282 11 dbSNP
rs780839798 12 dbSNP
rs770759485 13 dbSNP
rs774274756 15 dbSNP
rs777707337 16 dbSNP
rs199928721 21 dbSNP
rs752169680 22 dbSNP
rs898625518 23 dbSNP
rs377244384 25 dbSNP
rs754573252 26 dbSNP
rs1434247936 28 dbSNP
rs1393804840 29 dbSNP
rs1431227643 30 dbSNP
rs990595822 36 dbSNP
rs753542463 37 dbSNP
rs766587211 42 dbSNP
rs1190531743 46 dbSNP
rs1191955301 46 dbSNP
rs1419084637 47 dbSNP
rs1443764447 49 dbSNP
rs761153871 49 dbSNP
rs777203991 50 dbSNP
rs547054313 54 dbSNP
rs1371010490 59 dbSNP
rs1423895391 64 dbSNP
rs937528462 80 dbSNP
rs769075212 84 dbSNP
rs927397044 88 dbSNP
rs1436579134 93 dbSNP
rs1046256809 103 dbSNP
rs1441385240 105 dbSNP
rs950067660 108 dbSNP
rs535244835 109 dbSNP
rs759860542 125 dbSNP
rs1222331713 137 dbSNP
rs1333964252 142 dbSNP
rs1326864678 155 dbSNP
rs549040340 156 dbSNP
rs1490842555 162 dbSNP
rs1388595691 163 dbSNP
rs1241661678 182 dbSNP
rs1391669606 184 dbSNP
rs913236194 188 dbSNP
rs1390536116 190 dbSNP
rs151236982 199 dbSNP
rs993858952 200 dbSNP
rs896777407 205 dbSNP
rs1163152854 209 dbSNP
rs956623414 219 dbSNP
rs372463966 236 dbSNP
rs531187111 237 dbSNP
rs1009123653 239 dbSNP
rs890696630 241 dbSNP
rs1317013917 242 dbSNP
rs747566982 243 dbSNP
rs775813861 249 dbSNP
rs564007970 250 dbSNP
rs964246533 251 dbSNP
rs190841841 260 dbSNP
rs1470022701 278 dbSNP
rs1245710859 293 dbSNP
rs1313485120 298 dbSNP
rs1359066142 309 dbSNP
rs1229464762 314 dbSNP
rs1018012906 319 dbSNP
rs986970674 322 dbSNP
rs1218156304 327 dbSNP
rs1408088455 331 dbSNP
rs550334857 343 dbSNP
rs528867831 344 dbSNP
rs748792254 348 dbSNP
rs79726305 349 dbSNP
rs1386933844 351 dbSNP
rs1473066953 353 dbSNP
rs935347243 354 dbSNP
rs1219758682 356 dbSNP
rs994388973 357 dbSNP
rs923913672 365 dbSNP
rs982066259 373 dbSNP
rs1489105611 388 dbSNP
rs539912909 389 dbSNP
rs528275250 390 dbSNP
rs1335141039 393 dbSNP
rs143538336 397 dbSNP
rs73413212 398 dbSNP
rs1279514171 410 dbSNP
rs1230316186 422 dbSNP
rs1348581994 422 dbSNP
rs1276574852 424 dbSNP
rs990648310 426 dbSNP
rs1323084913 429 dbSNP
rs1235447491 435 dbSNP
rs777247714 436 dbSNP
rs1026739896 437 dbSNP
rs1346199788 439 dbSNP
rs1302704709 440 dbSNP
rs545582593 442 dbSNP
rs1180945727 443 dbSNP
rs1362710368 459 dbSNP
rs755395282 461 dbSNP
rs1231106532 467 dbSNP
rs557148426 505 dbSNP
rs1182255761 513 dbSNP
rs1400523774 517 dbSNP
rs1428075517 523 dbSNP
rs1406364095 537 dbSNP
rs1467878413 539 dbSNP
rs1174808824 546 dbSNP
rs961087292 549 dbSNP
rs1019317347 550 dbSNP
rs1478665795 552 dbSNP
rs1053055085 554 dbSNP
rs1415437214 555 dbSNP
rs1427982176 556 dbSNP
rs925186164 557 dbSNP
rs1478563132 560 dbSNP
rs1007878256 565 dbSNP
rs1345019434 567 dbSNP
rs1221857222 569 dbSNP
rs575192266 579 dbSNP
rs1258015181 583 dbSNP
rs557199037 590 dbSNP
rs747618201 597 dbSNP
rs942522494 615 dbSNP
rs1270697286 619 dbSNP
rs954978967 631 dbSNP
rs1029240735 643 dbSNP
rs535646049 644 dbSNP
rs541891552 651 dbSNP
rs955308625 661 dbSNP
rs1479182962 673 dbSNP
rs574739039 674 dbSNP
rs996367279 685 dbSNP
rs1377851181 686 dbSNP
rs1025433894 688 dbSNP
rs1167693332 705 dbSNP
rs972390828 706 dbSNP
rs962392962 709 dbSNP
rs893925735 711 dbSNP
rs866820826 713 dbSNP
rs77565502 718 dbSNP
rs535071077 721 dbSNP
rs1002207367 734 dbSNP
rs1331889325 737 dbSNP
rs565080150 747 dbSNP
rs753518773 748 dbSNP
rs1227057470 749 dbSNP
rs1268170491 750 dbSNP
rs1000047316 752 dbSNP
rs780975473 755 dbSNP
rs751209765 756 dbSNP
rs1014304475 758 dbSNP
rs891871914 781 dbSNP
rs1342566720 788 dbSNP
rs1271016552 789 dbSNP
rs1053157309 790 dbSNP
rs1046420556 792 dbSNP
rs935991408 799 dbSNP
rs949379555 805 dbSNP
rs559243524 807 dbSNP
rs1054930125 811 dbSNP
rs931181575 815 dbSNP
rs1043602390 818 dbSNP
rs546679390 823 dbSNP
rs1391598451 824 dbSNP
rs911024170 826 dbSNP
rs533250058 831 dbSNP
rs1367044261 832 dbSNP
rs1173542359 835 dbSNP
rs779619483 844 dbSNP
rs987032250 845 dbSNP
rs1357184620 847 dbSNP
rs79817222 848 dbSNP
rs570290315 851 dbSNP
rs1185546787 854 dbSNP
rs1485272129 858 dbSNP
rs912309982 860 dbSNP
rs986496325 865 dbSNP
rs1466481744 874 dbSNP
rs1189593943 876 dbSNP
rs953658946 880 dbSNP
rs962342933 886 dbSNP
rs1029250767 889 dbSNP
rs548832251 894 dbSNP
rs909566192 901 dbSNP
rs1201800809 904 dbSNP
rs996806757 913 dbSNP
rs958243980 915 dbSNP
rs1369086793 922 dbSNP
rs1453184761 924 dbSNP
rs980338674 929 dbSNP
rs1032948973 934 dbSNP
rs970721057 938 dbSNP
rs1335802004 942 dbSNP
rs1380370275 948 dbSNP
rs1397660947 949 dbSNP
rs999697631 950 dbSNP
rs1014833260 951 dbSNP
rs956238398 955 dbSNP
rs1273855314 956 dbSNP
rs1214198024 958 dbSNP
rs148729338 961 dbSNP
rs1360205237 964 dbSNP
rs1286261248 969 dbSNP
rs568001745 978 dbSNP
rs546300326 981 dbSNP
rs1184068192 985 dbSNP
rs1257488106 989 dbSNP
rs1031689865 998 dbSNP
rs114299740 999 dbSNP
rs1414330921 1004 dbSNP
rs765402887 1009 dbSNP
rs1176005878 1013 dbSNP
rs563833955 1019 dbSNP
rs1357173091 1028 dbSNP
rs1467391093 1034 dbSNP
rs1303295680 1042 dbSNP
rs1372505043 1043 dbSNP
rs1467685745 1044 dbSNP
rs1039454358 1051 dbSNP
rs1350628418 1060 dbSNP
rs1007592835 1062 dbSNP
rs1013544977 1070 dbSNP
rs895130009 1073 dbSNP
rs1281017279 1074 dbSNP
rs1310741542 1077 dbSNP
rs1354611003 1082 dbSNP
rs1212700772 1086 dbSNP
rs1257015531 1088 dbSNP
rs116829549 1097 dbSNP
rs1203694488 1102 dbSNP
rs145235541 1104 dbSNP
rs919834412 1113 dbSNP
rs1198886148 1116 dbSNP
rs1163939331 1119 dbSNP
rs1423336241 1121 dbSNP
rs1037310090 1127 dbSNP
rs1443803401 1131 dbSNP
rs201810594 1144 dbSNP
rs1353746760 1150 dbSNP
rs918436011 1154 dbSNP
rs764543103 1160 dbSNP
rs1403804366 1161 dbSNP
rs35552191 1162 dbSNP
rs767360632 1168 dbSNP
rs1280909523 1170 dbSNP
rs939859318 1171 dbSNP
rs1369270412 1178 dbSNP
rs912320034 1182 dbSNP
rs986509139 1184 dbSNP
rs953710642 1186 dbSNP
rs941091745 1187 dbSNP
rs563450148 1191 dbSNP
rs1226785546 1198 dbSNP
rs1277403239 1200 dbSNP
rs1483387794 1201 dbSNP
rs760909592 1202 dbSNP
rs1233510017 1209 dbSNP
rs980165672 1216 dbSNP
rs144312505 1224 dbSNP
rs917478621 1234 dbSNP
rs1170342844 1235 dbSNP
rs1305914729 1241 dbSNP
rs993109921 1242 dbSNP
rs80033474 1243 dbSNP
rs1247108182 1245 dbSNP
rs1359139596 1247 dbSNP
rs199968631 1258 dbSNP
rs867703460 1260 dbSNP
rs1436687009 1261 dbSNP
rs1287952770 1280 dbSNP
rs1449638063 1286 dbSNP
rs966813083 1287 dbSNP
rs968765415 1289 dbSNP
rs1297046746 1290 dbSNP
rs1439437086 1291 dbSNP
rs772507245 1295 dbSNP
rs1351210995 1303 dbSNP
rs541426280 1305 dbSNP
rs1303357028 1315 dbSNP
rs895222941 1316 dbSNP
rs1383153064 1322 dbSNP
rs577444354 1325 dbSNP
rs181619868 1346 dbSNP
rs995515558 1347 dbSNP
rs760079643 1351 dbSNP
rs898438121 1354 dbSNP
rs1036914186 1358 dbSNP
rs939837486 1364 dbSNP
rs1479709327 1372 dbSNP
rs1248490750 1382 dbSNP
rs1248576610 1384 dbSNP
rs139275403 1385 dbSNP
rs1050844899 1401 dbSNP
rs753868623 1402 dbSNP
rs921013459 1404 dbSNP
rs1490265223 1407 dbSNP
rs1415278951 1409 dbSNP
rs1405446175 1410 dbSNP
rs62402194 1420 dbSNP
rs1242778522 1421 dbSNP
rs1318009520 1424 dbSNP
rs1306942089 1434 dbSNP
rs1436915874 1442 dbSNP
rs935647983 1451 dbSNP
rs925529586 1470 dbSNP
rs1366433855 1471 dbSNP
rs978345416 1475 dbSNP
rs966863976 1485 dbSNP
rs1025130151 1487 dbSNP
rs1044174240 1487 dbSNP
rs1222612656 1494 dbSNP
rs541911437 1508 dbSNP
rs554967765 1524 dbSNP
rs948362499 1526 dbSNP
rs572982310 1529 dbSNP
rs190270305 1536 dbSNP
rs4598 1554 dbSNP
rs11545298 1569 dbSNP
rs1363343508 1574 dbSNP
rs1239143257 1578 dbSNP
rs1033759022 1582 dbSNP
rs1299736497 1586 dbSNP
rs145549266 1587 dbSNP
rs1176119341 1588 dbSNP
rs1409179172 1590 dbSNP
rs146244580 1620 dbSNP
rs780781261 1627 dbSNP
rs898454893 1637 dbSNP
rs1389793062 1638 dbSNP
rs1414266122 1646 dbSNP
rs924900647 1652 dbSNP
rs1308416554 1653 dbSNP
rs866162842 1654 dbSNP
rs1200251038 1657 dbSNP
rs1287778420 1658 dbSNP
rs1348764429 1667 dbSNP
rs1230417646 1674 dbSNP
rs1015943557 1677 dbSNP
rs1004103414 1681 dbSNP
rs968882919 1685 dbSNP
rs1198495573 1690 dbSNP
rs1280551706 1694 dbSNP
rs1442901685 1695 dbSNP
rs1267080369 1699 dbSNP
rs528054099 1703 dbSNP
rs1203789657 1706 dbSNP
rs1207217339 1715 dbSNP
rs1248921279 1716 dbSNP
rs1018093531 1723 dbSNP
rs986243919 1725 dbSNP
rs1182370866 1727 dbSNP
rs1428181045 1734 dbSNP
rs186933413 1736 dbSNP
rs891035403 1737 dbSNP
rs1260547306 1739 dbSNP
rs143441503 1749 dbSNP
rs1171186326 1758 dbSNP
rs1214272585 1759 dbSNP
rs1415527202 1763 dbSNP
rs868443083 1764 dbSNP
rs1307988124 1777 dbSNP
rs1368709237 1783 dbSNP
rs373767064 1786 dbSNP
rs578185840 1787 dbSNP
rs899589188 1788 dbSNP
rs1330733130 1798 dbSNP
rs1231388076 1805 dbSNP
rs1283303856 1808 dbSNP
rs1001353878 1825 dbSNP
rs1384670181 1830 dbSNP
rs1054172706 1842 dbSNP
rs1227520455 1850 dbSNP
rs1272399706 1853 dbSNP
rs897064899 1860 dbSNP
rs1205239316 1864 dbSNP
rs1015556783 1871 dbSNP
rs116120255 1873 dbSNP
rs1279721655 1874 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.612 9.6e-4 0.613 9.4e-4 23 Click to see details
GSE38226 Liver fibrosis 0.598 2.1e-3 0.302 9.2e-2 21 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.811 4.0e-3 0.767 7.9e-3 9 Click to see details
GSE17306 Multiple myeloma 0.32 1.2e-2 0.228 5.8e-2 49 Click to see details
GSE21687 Ependynoma primary tumors -0.274 1.4e-2 -0.281 1.2e-2 64 Click to see details
GSE21032 Prostate cancer 0.191 4.2e-2 0.167 6.6e-2 83 Click to see details
GSE14794 Lymphoblastoid cells 0.17 5.5e-2 0.136 1.0e-1 90 Click to see details
GSE21849 B cell lymphoma 0.291 6.3e-2 0.296 5.9e-2 29 Click to see details
GSE28260 Renal cortex and medulla 0.401 8.7e-2 0.478 4.9e-2 13 Click to see details
GSE17498 Multiple myeloma 0.202 1.1e-1 0.168 1.5e-1 40 Click to see details
GSE32688 Pancreatic cancer 0.216 1.2e-1 0.356 2.3e-2 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.259 1.4e-1 0.224 1.7e-1 20 Click to see details
GSE28544 Breast cancer 0.233 1.4e-1 0.224 1.5e-1 24 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.227 1.4e-1 -0.383 2.9e-2 25 Click to see details
GSE27834 Pluripotent stem cells -0.283 1.4e-1 -0.385 7.0e-2 16 Click to see details
GSE19350 CNS germ cell tumors 0.239 2.3e-1 0.119 3.6e-1 12 Click to see details
GSE19783 ER- ER- breast cancer 0.054 3.2e-1 -0.013 4.5e-1 79 Click to see details
GSE19783 ER+ ER+ breast cancer -0.09 3.5e-1 0.042 4.3e-1 20 Click to see details
GSE26953 Aortic valvular endothelial cells 0.026 4.5e-1 -0.016 4.7e-1 24 Click to see details
GSE19536 Breast cancer 0.009 4.6e-1 -0.010 4.6e-1 100 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.006 4.9e-1 0.017 4.7e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
STAD 0.578 0 0.575 0 32 Click to see details
KIRC 0.313 0 0.239 0.02 68 Click to see details
CHOL 0.697 0.02 0.617 0.04 9 Click to see details
LIHC 0.268 0.03 0.229 0.06 49 Click to see details
KICH 0.316 0.06 0.338 0.05 25 Click to see details
LUSC 0.205 0.11 0.141 0.2 38 Click to see details
HNSC -0.1 0.26 -0.028 0.43 42 Click to see details
THCA -0.081 0.27 -0.070 0.3 59 Click to see details
PRAD -0.077 0.3 -0.115 0.21 50 Click to see details
PAAD 0.404 0.3 0.400 0.3 4 Click to see details
BRCA -0.053 0.32 0.033 0.38 83 Click to see details
CESC 0.432 0.36 0.500 0.33 3 Click to see details
KIRP -0.062 0.37 0.030 0.44 32 Click to see details
PCPG 0.357 0.38 0.500 0.33 3 Click to see details
BLCA -0.047 0.43 -0.059 0.41 17 Click to see details
ESCA 0.058 0.43 0.027 0.47 11 Click to see details
UCEC -0.007 0.49 -0.100 0.34 19 Click to see details
LUAD -0.009 0.49 0.112 0.36 12 Click to see details
LUAD -0.009 0.49 0.112 0.36 12 Click to see details
373 hsa-miR-454-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT007251 SMAD4 SMAD family member 4 5 8
MIRT039219 KCTD12 potassium channel tetramerization domain containing 12 1 1
MIRT039220 LRRC8D leucine rich repeat containing 8 VRAC subunit D 1 1
MIRT039221 ZBTB4 zinc finger and BTB domain containing 4 2 7
MIRT039222 SPTSSA serine palmitoyltransferase small subunit A 1 1
MIRT039223 PRKCSH protein kinase C substrate 80K-H 1 1
MIRT039224 METTL2A methyltransferase like 2A 1 1
MIRT039225 C6orf120 chromosome 6 open reading frame 120 1 1
MIRT039226 CSPP1 centrosome and spindle pole associated protein 1 1 1
MIRT039227 CHD7 chromodomain helicase DNA binding protein 7 1 1
MIRT039228 LTN1 listerin E3 ubiquitin protein ligase 1 1 1
MIRT039229 RAP2C RAP2C, member of RAS oncogene family 1 1
MIRT039230 RPL4 ribosomal protein L4 1 1
MIRT039231 POLR2A RNA polymerase II subunit A 1 1
MIRT039232 MRPL37 mitochondrial ribosomal protein L37 1 1
MIRT039233 BAHCC1 BAH domain and coiled-coil containing 1 1 1
MIRT039234 SIK3 SIK family kinase 3 1 1
MIRT039235 ZNF805 zinc finger protein 805 1 1
MIRT039236 TET1 tet methylcytosine dioxygenase 1 1 1
MIRT039237 HMGXB3 HMG-box containing 3 1 1
MIRT039238 POFUT2 protein O-fucosyltransferase 2 1 1
MIRT039239 PCSK6 proprotein convertase subtilisin/kexin type 6 1 1
MIRT039240 BHLHE40 basic helix-loop-helix family member e40 1 1
MIRT039241 MED12 mediator complex subunit 12 1 1
MIRT039242 FLNC filamin C 1 1
MIRT039243 STK38 serine/threonine kinase 38 1 1
MIRT039244 MRPS35 mitochondrial ribosomal protein S35 1 1
MIRT039245 TP53 tumor protein p53 1 1
MIRT039246 CNOT1 CCR4-NOT transcription complex subunit 1 1 1
MIRT039247 PPP1R7 protein phosphatase 1 regulatory subunit 7 1 1
MIRT039248 GID4 GID complex subunit 4 homolog 1 1
MIRT039249 PHF12 PHD finger protein 12 2 3
MIRT039250 UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 1 1
MIRT057500 CEP55 centrosomal protein 55 2 4
MIRT060511 PPP6R3 protein phosphatase 6 regulatory subunit 3 2 2
MIRT061519 OTUD3 OTU deubiquitinase 3 2 2
MIRT061804 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 10
MIRT062715 MLEC malectin 2 4
MIRT063602 FBXO28 F-box protein 28 2 2
MIRT064810 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT065626 CLIC4 chloride intracellular channel 4 2 4
MIRT065898 RAB5B RAB5B, member RAS oncogene family 2 8
MIRT071011 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT071920 ZFYVE9 zinc finger FYVE-type containing 9 2 2
MIRT075119 C16ORF70 chromosome 16 open reading frame 70 2 4
MIRT076031 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 6
MIRT079272 NPTX1 neuronal pentraxin 1 2 2
MIRT079362 CCDC137 coiled-coil domain containing 137 2 2
MIRT081131 LDLR low density lipoprotein receptor 2 6
MIRT083130 BTBD3 BTB domain containing 3 2 12
MIRT083156 SEC23B Sec23 homolog B, coat complex II component 2 4
MIRT086442 NABP1 nucleic acid binding protein 1 2 6
MIRT087868 CBY1 chibby family member 1, beta catenin antagonist 2 4
MIRT088348 MAPRE3 microtubule associated protein RP/EB family member 3 2 8
MIRT090809 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT090904 ARHGEF26 Rho guanine nucleotide exchange factor 26 2 2
MIRT091219 USP13 ubiquitin specific peptidase 13 2 2
MIRT091700 TGFBR2 transforming growth factor beta receptor 2 2 6
MIRT092494 PTPRG protein tyrosine phosphatase, receptor type G 2 2
MIRT095388 UBE2D2 ubiquitin conjugating enzyme E2 D2 2 2
MIRT096901 ERBB2IP erbb2 interacting protein 2 2
MIRT097422 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT097465 PAPD4 poly(A) RNA polymerase D4, non-canonical 2 2
MIRT099324 QKI QKI, KH domain containing RNA binding 2 4
MIRT099841 SOX4 SRY-box 4 2 10
MIRT100782 ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2 2
MIRT101821 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT102154 POP7 POP7 homolog, ribonuclease P/MRP subunit 2 4
MIRT102235 HBP1 HMG-box transcription factor 1 2 2
MIRT102624 UBN2 ubinuclein 2 2 8
MIRT105313 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT105436 ATP6V1B2 ATPase H+ transporting V1 subunit B2 2 10
MIRT105807 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT107283 FAM73B mitoguardin 2 2 2
MIRT108268 HABP4 hyaluronan binding protein 4 2 4
MIRT108885 HPRT1 hypoxanthine phosphoribosyltransferase 1 2 2
MIRT109677 KLHL15 kelch like family member 15 2 6
MIRT109831 MID1IP1 MID1 interacting protein 1 2 8
MIRT123867 FZD6 frizzled class receptor 6 2 8
MIRT126574 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT130148 TXNIP thioredoxin interacting protein 2 6
MIRT132502 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT134787 CCND2 cyclin D2 2 2
MIRT139885 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT142443 TNRC6A trinucleotide repeat containing 6A 2 6
MIRT154001 PRNP prion protein 2 2
MIRT162279 LMLN leishmanolysin like peptidase 2 4
MIRT164540 MSMO1 methylsterol monooxygenase 1 2 2
MIRT178076 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT178935 C11ORF57 chromosome 11 open reading frame 57 2 2
MIRT179073 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 6
MIRT180851 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 4
MIRT182976 TROVE2 TROVE domain family member 2 2 2
MIRT193030 TMOD3 tropomodulin 3 2 8
MIRT195765 ATMIN ATM interactor 2 6
MIRT196627 TAOK1 TAO kinase 1 2 6
MIRT212153 CLCN3 chloride voltage-gated channel 3 2 4
MIRT217615 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 2
MIRT220701 MTPN myotrophin 2 4
MIRT222278 CCT6A chaperonin containing TCP1 subunit 6A 2 2
MIRT223641 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT224762 DPYSL2 dihydropyrimidinase like 2 2 2
MIRT227998 NFIB nuclear factor I B 2 4
MIRT230983 PRRG4 proline rich and Gla domain 4 2 2
MIRT242671 SALL3 spalt like transcription factor 3 2 4
MIRT243099 LCLAT1 lysocardiolipin acyltransferase 1 2 4
MIRT244079 EDN1 endothelin 1 2 2
MIRT246462 ZBTB7B zinc finger and BTB domain containing 7B 2 2
MIRT248079 SLC38A2 solute carrier family 38 member 2 2 4
MIRT270943 GPRC5A G protein-coupled receptor class C group 5 member A 2 2
MIRT295182 ZNF317 zinc finger protein 317 2 4
MIRT296535 STX16 syntaxin 16 2 2
MIRT301578 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT316378 PPP1R14C protein phosphatase 1 regulatory inhibitor subunit 14C 2 2
MIRT323697 PLEKHF2 pleckstrin homology and FYVE domain containing 2 2 4
MIRT327914 CHIC1 cysteine rich hydrophobic domain 1 2 2
MIRT367113 ZNF711 zinc finger protein 711 2 4
MIRT368759 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT407342 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT448324 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT448957 CDK19 cyclin dependent kinase 19 2 4
MIRT449145 UQCRB ubiquinol-cytochrome c reductase binding protein 2 2
MIRT454117 MRPL52 mitochondrial ribosomal protein L52 2 2
MIRT459833 TPP1 tripeptidyl peptidase 1 2 2
MIRT460418 TNFRSF10B TNF receptor superfamily member 10b 2 4
MIRT461658 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT462949 ZNF800 zinc finger protein 800 2 12
MIRT463646 YY1 YY1 transcription factor 2 8
MIRT464853 RPS27A ribosomal protein S27a 2 12
MIRT464873 UBB ubiquitin B 2 8
MIRT466321 THRA thyroid hormone receptor, alpha 2 2
MIRT466828 STX6 syntaxin 6 2 6
MIRT467415 SNTB1 syntrophin beta 1 2 4
MIRT467456 SNAPIN SNAP associated protein 2 2
MIRT468561 SERINC3 serine incorporator 3 2 10
MIRT469808 RAB14 RAB14, member RAS oncogene family 2 2
MIRT469869 PXK PX domain containing serine/threonine kinase like 2 8
MIRT470335 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT473777 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT474740 KIF13A kinesin family member 13A 2 6
MIRT474957 KCTD10 potassium channel tetramerization domain containing 10 2 4
MIRT475482 HSPA8 heat shock protein family A (Hsp70) member 8