miRTarBase - #MIRT040476


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pre-miRNA Information
pre-miRNA hsa-mir-605   
Genomic Coordinates chr10: 51299573 - 51299655
Synonyms MIRN605, hsa-mir-605, MIR605
Description Homo sapiens miR-605 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-605-5p
Sequence 16| UAAAUCCCAUGGUGCCUUCUCCU |38
Evidence Experimental
Experiments SAGE
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 10 + 51299590 29233923, 28550310 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs113212828 2 dbSNP
rs1265154909 7 dbSNP
rs76759855 9 dbSNP
rs1032735304 10 dbSNP
rs1318073696 10 dbSNP
rs1486056689 11 dbSNP
rs1225930966 12 dbSNP
rs1011066926 14 dbSNP
rs1261327694 19 dbSNP
rs1020985018 22 dbSNP
rs1426923077 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol YBX1   
Synonyms BP-8, CBF-A, CSDA2, CSDB, DBPB, EFI-A, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1
Description Y-box binding protein 1
Transcript NM_004559   
Expression
Putative miRNA Targets on YBX1
3'UTR of YBX1
(miRNA target sites are highlighted)		 
>YBX1|NM_004559|3'UTR
   1 ATGCCGGCTTACCATCTCTACCATCATCCGGTTTAGTCATCCAACAAGAAGAAATATGAAATTCCAGCAATAAGAAATGA
  81 ACAAAAGATTGGAGCTGAAGACCTAAAGTGCTTGCTTTTTGCCCGTTGACCAGATAAATAGAACTATCTGCATTATCTAT
 161 GCAGCATGGGGTTTTTATTATTTTTACCTAAAGACGTCTCTTTTTGGTAATAACAAACGTGTTTTTTAAAAAAGCCTGGT
 241 TTTTCTCAATACGCCTTTAAAGGTTTTTAAATTGTTTCATATCTGGTCAAGTTGAGATTTTTAAGAACTTCATTTTTAAT
 321 TTGTAATAAAAGTTTACAACTTGATTTTTTCAAAAAAGTCAACAAACTGCAAGCACCTGTTAATAAAGGTCTTAAATAAT
 401 TGTCTTTGTGTAAATTTGTCTAGTTTTGCTTTAGTTTGTAAGTATTTAGCTATTTATAGGACCCTTAGCTTGACCCAGTC
 481 TACAAATAGATGATGCTCACTGGTAATTCCCTCAGGTAAAATGTCTCAAAATCTCTAATCCTTTAAGTGGCATGCCTGTG
 561 GGCCCATACTAAAAATTAGAAAATACATACTCTGATAACCTGGCCATTTTTCATTGAAGGATTTAGCTCATTTGTAAGAA
 641 AGACTTGAGTGTAGATTTTGGGTGGGTCCCTTTGGCTGTGAGGCATTGTTTAAAAGGGCATTGCTCTAGCCTAGACCGAC
 721 CAGACTCTCATCCTGCTCCACTTAGTTTTGTCACCTTGGGAGAATTTGTTTCAGTGTGTCAATTGAAGATGCCAATTGAA
 801 GTGTTAGGACAACCTGTCACACTGCCTGGTGTGGTCATCAAATATTGGTTCAGCTCCTTATGTCCTAGAGATGGAAACAA
 881 GTAATATAAAACCCATGGGAAAGCTGCTTAGGAACATGGAGGTTGGTGAGCTTGTAATTATGTGGTTCTCAACACCTTAA
 961 ATCCTAAGCCTAGTCTGGCTGATCTTTTCTCTTTTTGAGACGGAGTCTTGTTCTGTCATCAGGCTGGAGTACAGTGGCAC
1041 AATCTTGGCTCACTGCAACCTCCACCTCTAGGTTTAAGCGATTCTCCTGCCTCGGCCACCTTAGTAGCTGGGAGTACAGG
1121 TGCGTGCCACCACACCCAGCTAATTTTTGTATTTTTAATAGAGATGGGGTTGCACTGTGTTAGCCAGGATGGTCTTGATC
1201 TCTTGACCTTGTGATCCGCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCACCTGGCCTCTCTG
1281 GCTTTTGTTTTCTAATGTTTTGTTAGATGTTCTTTGGCTTGCTTTGTGAAATAGTCATGTAGTTGATAGTGACTGCTGCC
1361 CCGAAACACTCCAGATCATCCTGGCCAGCTATCAGGGCCCAGGGGAAGCAGACAGTAGGGGTCGGGAGTAGGCCAGAGTG
1441 GCACATCAGGAATCCTGCAGTGCTGTGGAAGTCATCTCCTGCTTGGGACTAACTCTTTGCAGAGGACTTGATAAGAGACT
1521 ACTCAAAAAAAATTTTTTTAACCCTACTTAGTGTAAATATCTGTACTGCAGAAGTGAGTTAGCCTATTTCTTGCTGGTGT
1601 TCATGAAAATACTGTGTTGGCAAGAGTGCAGTGGACCTGAAACTTCAACTGTTGGTAGCATCTAAACTGTTACTTACAAC
1681 TGCAGACGCACACAGTCCCTGACTTAAACAGTGGTTTGACTTAGGGGCTTTTAGTGGGGTTACGGTTTCTACTGAATCAA
1761 CATTGTTTTCATGGCATCACAGAGTTGAAAAATCATAAATGAAACCATTGTAAGTTGACTGCAGTGTTGCCAACATTAAA
1841 TGCAGTTTCAACTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uccucuUCCGUGGUACCCUAAAu 5'
                | ||| ||||||:||| 
Target 5' ttatctATGCAGCATGGGGTTTt 3'
 153 - 175 153.00 -18.40
2 
miRNA  3' uccucUUCCGUGGUACCCUAAau 5'
               || |::|  |||||||  
Target 5' ctcccAAAGTGC--TGGGATTac 3'
 1230 - 1250 134.00 -8.30
3 
miRNA  3' uccUCUUCCGUGGU-ACCCUAAau 5'
             ||::| : ::| ||||:||  
Target 5' cttAGGGGCTTTTAGTGGGGTTac 3'
 1720 - 1743 120.00 -13.44
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30118640 2 COSMIC
COSN15618915 7 COSMIC
COSN27005383 8 COSMIC
COSN24308319 76 COSMIC
COSN30600544 99 COSMIC
COSN27252811 526 COSMIC
COSN6036117 666 COSMIC
COSN5372116 758 COSMIC
COSN25394751 771 COSMIC
COSN21075195 773 COSMIC
COSN22607566 897 COSMIC
COSN31579488 1000 COSMIC
COSN28663206 1032 COSMIC
COSN31487394 1231 COSMIC
COSN31543458 1240 COSMIC
COSN8470152 1245 COSMIC
COSN31565463 1275 COSMIC
COSN8638322 1297 COSMIC
COSN24297971 1310 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1200000409 4 dbSNP
rs769596821 6 dbSNP
rs773035669 7 dbSNP
rs1182811533 14 dbSNP
rs748925791 19 dbSNP
rs772622455 21 dbSNP
rs775917560 22 dbSNP
rs761102127 23 dbSNP
rs750808970 26 dbSNP
rs776606023 29 dbSNP
rs1460116514 30 dbSNP
rs367927170 31 dbSNP
rs1451386468 33 dbSNP
rs879073083 33 dbSNP
rs878992995 35 dbSNP
rs1171600458 38 dbSNP
rs766423055 41 dbSNP
rs1331657102 43 dbSNP
rs1376587673 45 dbSNP
rs1019003258 46 dbSNP
rs750706537 49 dbSNP
rs758617802 53 dbSNP
rs1452100879 57 dbSNP
rs572472208 64 dbSNP
rs577581034 69 dbSNP
rs1258313236 80 dbSNP
rs944543999 87 dbSNP
rs879004178 95 dbSNP
rs1213568122 96 dbSNP
rs1245213975 99 dbSNP
rs1336951973 106 dbSNP
rs1276102650 114 dbSNP
rs755185363 125 dbSNP
rs1236121967 126 dbSNP
rs534985759 129 dbSNP
rs1482115453 141 dbSNP
rs1181088574 145 dbSNP
rs1036558354 154 dbSNP
rs897564700 155 dbSNP
rs978399393 159 dbSNP
rs1420772187 161 dbSNP
rs994958821 163 dbSNP
rs534048657 164 dbSNP
rs765444643 170 dbSNP
rs1410563358 171 dbSNP
rs1469878229 175 dbSNP
rs768083037 177 dbSNP
rs960930115 185 dbSNP
rs1357097690 197 dbSNP
rs1446215846 198 dbSNP
rs992305907 201 dbSNP
rs1238549411 204 dbSNP
rs1302617844 208 dbSNP
rs1280186807 209 dbSNP
rs1374563657 209 dbSNP
rs1346465824 211 dbSNP
rs1303318417 212 dbSNP
rs1232665286 215 dbSNP
rs904835804 216 dbSNP
rs554268625 219 dbSNP
rs1034585664 223 dbSNP
rs11809002 225 dbSNP
rs543244032 228 dbSNP
rs1435425247 232 dbSNP
rs1374870099 241 dbSNP
rs1171753297 243 dbSNP
rs929624764 245 dbSNP
rs1020823829 253 dbSNP
rs1047004669 261 dbSNP
rs891013342 264 dbSNP
rs967497136 286 dbSNP
rs1187728008 289 dbSNP
rs1485065995 294 dbSNP
rs943886445 301 dbSNP
rs758786511 305 dbSNP
rs979215661 309 dbSNP
rs1356424479 310 dbSNP
rs370610518 311 dbSNP
rs900597149 315 dbSNP
rs1223615782 316 dbSNP
rs1209729797 323 dbSNP
rs1371551302 326 dbSNP
rs1251667054 328 dbSNP
rs1481524686 336 dbSNP
rs778464254 337 dbSNP
rs1250989369 341 dbSNP
rs1311111797 351 dbSNP
rs1401821375 356 dbSNP
rs1480453047 357 dbSNP
rs925976074 362 dbSNP
rs1422511660 365 dbSNP
rs1413527201 373 dbSNP
rs1158236130 376 dbSNP
rs1022325988 377 dbSNP
rs1170792156 381 dbSNP
rs1415619249 386 dbSNP
rs376315754 387 dbSNP
rs1474672407 390 dbSNP
rs1254823386 393 dbSNP
rs562935924 410 dbSNP
rs1485888012 417 dbSNP
rs903880600 417 dbSNP
rs1215632537 420 dbSNP
rs986040682 424 dbSNP
rs1292466656 443 dbSNP
rs911794203 444 dbSNP
rs1234177476 446 dbSNP
rs999917847 447 dbSNP
rs944570299 448 dbSNP
rs576820194 452 dbSNP
rs1432033659 454 dbSNP
rs1036205552 457 dbSNP
rs1362669974 457 dbSNP
rs747500999 459 dbSNP
rs1288229444 463 dbSNP
rs1428534666 475 dbSNP
rs1351468576 479 dbSNP
rs1326295785 482 dbSNP
rs1460637638 485 dbSNP
rs1415237723 487 dbSNP
rs919043790 488 dbSNP
rs930426372 503 dbSNP
rs1031272159 510 dbSNP
rs1350447492 511 dbSNP
rs961220035 513 dbSNP
rs200264018 514 dbSNP
rs746670524 514 dbSNP
rs888946002 514 dbSNP
rs992337171 514 dbSNP
rs1276657252 515 dbSNP
rs1212772346 518 dbSNP
rs1023769763 521 dbSNP
rs1365663231 522 dbSNP
rs371056693 524 dbSNP
rs58708564 524 dbSNP
rs973854308 524 dbSNP
rs149064241 527 dbSNP
rs1296573481 529 dbSNP
rs1308964475 530 dbSNP
rs1397462634 535 dbSNP
rs961993800 535 dbSNP
rs1202797046 537 dbSNP
rs114662877 540 dbSNP
rs1490487638 543 dbSNP
rs1224684647 546 dbSNP
rs748768693 555 dbSNP
rs372666385 556 dbSNP
rs899708733 558 dbSNP
rs973113331 561 dbSNP
rs947206994 562 dbSNP
rs1043838880 565 dbSNP
rs1167125080 566 dbSNP
rs1391664905 572 dbSNP
rs1372189370 575 dbSNP
rs903914459 578 dbSNP
rs369030448 586 dbSNP
rs768203865 593 dbSNP
rs1326181150 594 dbSNP
rs778610958 594 dbSNP
rs896745342 597 dbSNP
rs185245480 605 dbSNP
rs1419995650 607 dbSNP
rs896062606 610 dbSNP
rs1435846910 611 dbSNP
rs1354826003 622 dbSNP
rs1175647789 624 dbSNP
rs188160730 626 dbSNP
rs1020454665 629 dbSNP
rs778016465 629 dbSNP
rs1226534054 635 dbSNP
rs967927517 643 dbSNP
rs771819010 644 dbSNP
rs529750946 645 dbSNP
rs1239543655 649 dbSNP
rs1033047201 658 dbSNP
rs953404774 663 dbSNP
rs1416228245 664 dbSNP
rs986084801 666 dbSNP
rs982470837 670 dbSNP
rs911858099 671 dbSNP
rs773182402 684 dbSNP
rs1454631776 697 dbSNP
rs965989947 721 dbSNP
rs1157284616 724 dbSNP
rs1476294876 727 dbSNP
rs965003380 731 dbSNP
rs1258382825 739 dbSNP
rs760627162 743 dbSNP
rs1484709376 744 dbSNP
rs549952910 748 dbSNP
rs563382824 749 dbSNP
rs1485453734 751 dbSNP
rs772990050 758 dbSNP
rs369330474 764 dbSNP
rs921160356 766 dbSNP
rs770813466 767 dbSNP
rs947242724 774 dbSNP
rs1187610795 775 dbSNP
rs1043254535 776 dbSNP
rs930458885 786 dbSNP
rs569709337 795 dbSNP
rs1287466738 802 dbSNP
rs1048863917 807 dbSNP
rs926357444 825 dbSNP
rs191586832 832 dbSNP
rs1445631665 833 dbSNP
rs935377260 833 dbSNP
rs1193893057 836 dbSNP
rs143065629 837 dbSNP
rs1052528171 840 dbSNP
rs565616999 845 dbSNP
rs1468716425 846 dbSNP
rs1272152602 848 dbSNP
rs1211370704 853 dbSNP
rs1454151489 854 dbSNP
rs758764374 856 dbSNP
rs533963608 866 dbSNP
rs1404787520 867 dbSNP
rs1270242354 872 dbSNP
rs1045365966 873 dbSNP
rs553869037 877 dbSNP
rs1042336053 885 dbSNP
rs1390979696 889 dbSNP
rs1433166322 890 dbSNP
rs574123224 895 dbSNP
rs1000303284 900 dbSNP
rs1398779559 902 dbSNP
rs1168546202 906 dbSNP
rs1383185268 907 dbSNP
rs1033098087 911 dbSNP
rs1449958191 912 dbSNP
rs1282317742 916 dbSNP
rs536300658 919 dbSNP
rs1355587305 921 dbSNP
rs1224320282 923 dbSNP
rs889205533 925 dbSNP
rs1439175839 935 dbSNP
rs1273214472 937 dbSNP
rs1004401778 938 dbSNP
rs1019344800 939 dbSNP
rs1273124341 951 dbSNP
rs1372263529 962 dbSNP
rs1434643887 967 dbSNP
rs1207646861 985 dbSNP
rs1329737721 986 dbSNP
rs1409453798 989 dbSNP
rs1243378707 991 dbSNP
rs377288453 992 dbSNP
rs1435227675 1000 dbSNP
rs1394308993 1009 dbSNP
rs1007558745 1019 dbSNP
rs1411468313 1022 dbSNP
rs1233103945 1024 dbSNP
rs1180578252 1031 dbSNP
rs1018962894 1040 dbSNP
rs966409838 1043 dbSNP
rs972035000 1056 dbSNP
rs41307904 1059 dbSNP
rs1190071400 1060 dbSNP
rs1349203211 1065 dbSNP
rs1236134514 1066 dbSNP
rs759650867 1072 dbSNP
rs1217860998 1075 dbSNP
rs183740735 1076 dbSNP
rs951897902 1089 dbSNP
rs1353200751 1092 dbSNP
rs188009120 1094 dbSNP
rs1159722922 1098 dbSNP
rs1414265442 1103 dbSNP
rs921194814 1106 dbSNP
rs9428 1123 dbSNP
rs926410177 1125 dbSNP
rs41303421 1130 dbSNP
rs978622240 1131 dbSNP
rs1408427529 1137 dbSNP
rs1157704433 1138 dbSNP
rs1415913031 1153 dbSNP
rs924480887 1154 dbSNP
rs1331927143 1156 dbSNP
rs1188073153 1162 dbSNP
rs56212742 1162 dbSNP
rs991886296 1163 dbSNP
rs1442816647 1171 dbSNP
rs917604347 1172 dbSNP
rs1257433926 1173 dbSNP
rs1208565006 1175 dbSNP
rs1449152272 1178 dbSNP
rs945025908 1180 dbSNP
rs3862220 1182 dbSNP
rs988660894 1184 dbSNP
rs1290151904 1185 dbSNP
rs377708710 1187 dbSNP
rs917989249 1188 dbSNP
rs1233989855 1203 dbSNP
rs949385401 1212 dbSNP
rs1301078340 1214 dbSNP
rs1227275766 1217 dbSNP
rs565615928 1222 dbSNP
rs1432805848 1226 dbSNP
rs1345612270 1242 dbSNP
rs1317343841 1244 dbSNP
rs3862221 1247 dbSNP
rs1263321108 1248 dbSNP
rs761463759 1257 dbSNP
rs1165107401 1260 dbSNP
rs903432937 1263 dbSNP
rs936209860 1285 dbSNP
rs1198410299 1286 dbSNP
rs1410972250 1287 dbSNP
rs1054552538 1293 dbSNP
rs1180691322 1294 dbSNP
rs1476663208 1295 dbSNP
rs905445925 1299 dbSNP
rs1208534024 1300 dbSNP
rs1463776374 1311 dbSNP
rs1276945798 1312 dbSNP
rs931595783 1326 dbSNP
rs1334348225 1337 dbSNP
rs1310628779 1339 dbSNP
rs1216305704 1343 dbSNP
rs1405529090 1350 dbSNP
rs1048632015 1351 dbSNP
rs887300855 1355 dbSNP
rs1183466048 1356 dbSNP
rs1432639805 1358 dbSNP
rs1396326262 1365 dbSNP
rs1004363832 1371 dbSNP
rs889258049 1372 dbSNP
rs1347649939 1375 dbSNP
rs1171934663 1377 dbSNP
rs572768367 1380 dbSNP
rs1007609727 1401 dbSNP
rs1019339002 1403 dbSNP
rs900901302 1405 dbSNP
rs1188426748 1408 dbSNP
rs1181579758 1409 dbSNP
rs1019433996 1415 dbSNP
rs879838583 1417 dbSNP
rs185369191 1418 dbSNP
rs1194550915 1419 dbSNP
rs993903527 1420 dbSNP
rs1026264747 1429 dbSNP
rs1488267449 1444 dbSNP
rs543807603 1445 dbSNP
rs984666849 1448 dbSNP
rs996477556 1449 dbSNP
rs1273846288 1451 dbSNP
rs1226065167 1466 dbSNP
rs1372998033 1477 dbSNP
rs1303833562 1485 dbSNP
rs1033532703 1488 dbSNP
rs1467747420 1493 dbSNP
rs959165466 1497 dbSNP
rs1171095805 1501 dbSNP
rs529806896 1509 dbSNP
rs1401159158 1511 dbSNP
rs1442317612 1514 dbSNP
rs1353405938 1522 dbSNP
rs917641155 1525 dbSNP
rs968413015 1527 dbSNP
rs1174677507 1573 dbSNP
rs1432923490 1578 dbSNP
rs1265536766 1587 dbSNP
rs979120807 1589 dbSNP
rs1368648249 1590 dbSNP
rs1409184863 1593 dbSNP
rs868552465 1595 dbSNP
rs1329482138 1598 dbSNP
rs1332390597 1598 dbSNP
rs1230596016 1599 dbSNP
rs1251164336 1603 dbSNP
rs1273897824 1603 dbSNP
rs1202983463 1608 dbSNP
rs1344676846 1610 dbSNP
rs1206356257 1611 dbSNP
rs1277333652 1612 dbSNP
rs1280909988 1614 dbSNP
rs1482349004 1615 dbSNP
rs978155807 1617 dbSNP
rs1205128206 1618 dbSNP
rs1310159152 1620 dbSNP
rs1268127619 1622 dbSNP
rs1434993162 1623 dbSNP
rs1308771278 1630 dbSNP
rs1391612297 1631 dbSNP
rs1372036718 1633 dbSNP
rs1196942577 1638 dbSNP
rs1416040766 1641 dbSNP
rs1377829179 1643 dbSNP
rs752933587 1644 dbSNP
rs79917566 1645 dbSNP
rs1054606774 1651 dbSNP
rs910747979 1652 dbSNP
rs1161638534 1653 dbSNP
rs943521307 1661 dbSNP
rs1040500506 1662 dbSNP
rs563518653 1664 dbSNP
rs918012842 1665 dbSNP
rs949408566 1673 dbSNP
rs532203251 1674 dbSNP
rs763277027 1679 dbSNP
rs980848848 1691 dbSNP
rs1239384139 1695 dbSNP
rs901916581 1708 dbSNP
rs993561413 1719 dbSNP
rs1328075308 1720 dbSNP
rs1048195909 1724 dbSNP
rs113290277 1727 dbSNP
rs1314131543 1730 dbSNP
rs1322426616 1733 dbSNP
rs1395953085 1737 dbSNP
rs1326680622 1742 dbSNP
rs141571265 1745 dbSNP
rs528365083 1748 dbSNP
rs1049143800 1751 dbSNP
rs1340568667 1752 dbSNP
rs1476262259 1753 dbSNP
rs866956665 1753 dbSNP
rs146181434 1755 dbSNP
rs1228234976 1760 dbSNP
rs1418661168 1761 dbSNP
rs1266550454 1764 dbSNP
rs887342185 1774 dbSNP
rs1421968365 1778 dbSNP
rs959218016 1780 dbSNP
rs1208156529 1787 dbSNP
rs190609974 1795 dbSNP
rs1215158279 1806 dbSNP
rs181914437 1813 dbSNP
rs1024762617 1816 dbSNP
rs1244760152 1830 dbSNP
rs1339247254 1832 dbSNP
rs1041163887 1834 dbSNP
rs1436297040 1841 dbSNP
rs556413409 1849 dbSNP
rs1299602782 1851 dbSNP
rs900935815 1857 dbSNP
rs966871674 1862 dbSNP
rs570151459 1867 dbSNP
rs1456423410 1869 dbSNP
rs1388078951 1874 dbSNP
rs924961407 1876 dbSNP
rs999847142 1883 dbSNP
rs374702510 1895 dbSNP
rs990384912 1896 dbSNP
rs1195153694 1898 dbSNP
rs1370158814 1898 dbSNP
rs1468624278 1899 dbSNP
rs910800506 1900 dbSNP
rs373941440 1904 dbSNP
rs1162104774 1912 dbSNP
rs1253658731 1913 dbSNP
rs1229783448 1915 dbSNP
rs992662003 1916 dbSNP
rs1024183198 1919 dbSNP
rs1385102104 1919 dbSNP
rs1331935163 1922 dbSNP
rs539280158 1925 dbSNP
rs1040950040 1926 dbSNP
rs1363385281 1931 dbSNP
rs926673711 1936 dbSNP
rs952839189 1938 dbSNP
rs984108136 1940 dbSNP
rs1454519259 1954 dbSNP
rs1245786002 1964 dbSNP
rs1196291869 1966 dbSNP
rs764579266 1967 dbSNP
rs908793333 1972 dbSNP
rs186885261 1976 dbSNP
rs1041281619 1977 dbSNP
rs1483030825 1983 dbSNP
rs1353196383 1984 dbSNP
rs1273061997 1986 dbSNP
rs1236969131 1998 dbSNP
rs929400432 1999 dbSNP
rs1047779592 2010 dbSNP
rs887807396 2014 dbSNP
rs1308690899 2015 dbSNP
rs370602278 2017 dbSNP
rs1368663441 2021 dbSNP
rs781742705 2022 dbSNP
rs895058816 2026 dbSNP
rs1464243631 2028 dbSNP
rs541323686 2029 dbSNP
rs1170488110 2032 dbSNP
rs554564522 2042 dbSNP
rs1470946673 2050 dbSNP
rs1412191564 2056 dbSNP
rs1182260940 2057 dbSNP
rs1025244217 2058 dbSNP
rs966537821 2059 dbSNP
rs574322585 2069 dbSNP
rs1213625239 2070 dbSNP
rs868213840 2084 dbSNP
rs1278317503 2089 dbSNP
rs1186836458 2092 dbSNP
rs1198994310 2093 dbSNP
rs1353136047 2104 dbSNP
rs891451260 2107 dbSNP
rs1412050747 2108 dbSNP
rs1295127685 2110 dbSNP
rs999710063 2119 dbSNP
rs1448631516 2128 dbSNP
rs1358413979 2134 dbSNP
rs1014211759 2135 dbSNP
rs141998793 2138 dbSNP
rs1402196242 2141 dbSNP
rs1156451581 2143 dbSNP
rs1388928947 2144 dbSNP
rs957738770 2145 dbSNP
rs985082996 2150 dbSNP
rs910854356 2152 dbSNP
rs563077482 2153 dbSNP
rs532065098 2156 dbSNP
rs923447560 2157 dbSNP
rs1449032840 2162 dbSNP
rs1269021870 2171 dbSNP
rs1034192828 2176 dbSNP
rs952791834 2178 dbSNP
rs1381876049 2180 dbSNP
rs190387992 2187 dbSNP
rs983559323 2192 dbSNP
rs12409527 2199 dbSNP
rs377066691 2200 dbSNP
rs1230345983 2201 dbSNP
rs942044966 2203 dbSNP
rs1319550668 2208 dbSNP
rs1266423588 2219 dbSNP
rs1328726846 2226 dbSNP
rs1055139841 2227 dbSNP
rs1164886882 2229 dbSNP
rs528394387 2242 dbSNP
rs754503241 2243 dbSNP
rs1413709855 2255 dbSNP
rs1180561381 2257 dbSNP
rs895110820 2258 dbSNP
rs949338639 2267 dbSNP
rs1046295439 2272 dbSNP
rs778466956 2274 dbSNP
rs1188222799 2276 dbSNP
rs1249003422 2276 dbSNP
rs1463730957 2280 dbSNP
rs922840800 2281 dbSNP
rs999363575 2282 dbSNP
rs1293447680 2285 dbSNP
rs1032084844 2287 dbSNP
rs1287715961 2293 dbSNP
rs548162225 2297 dbSNP
rs16829887 2298 dbSNP
rs1017914672 2302 dbSNP
rs1432567022 2305 dbSNP
rs530075832 2309 dbSNP
rs1293684809 2310 dbSNP
rs976769957 2316 dbSNP
rs11210698 2322 dbSNP
rs1433400512 2325 dbSNP
rs1013907730 2326 dbSNP
rs1361203006 2332 dbSNP
rs1432147648 2333 dbSNP
rs1391274144 2337 dbSNP
rs1045696783 2338 dbSNP
rs1447976660 2342 dbSNP
rs1427547255 2343 dbSNP
rs950990107 2347 dbSNP
rs74565211 2348 dbSNP
rs1245019214 2350 dbSNP
rs1207264096 2353 dbSNP
rs770915532 2358 dbSNP
rs1001375760 2359 dbSNP
rs951970735 2368 dbSNP
rs1301614382 2377 dbSNP
rs776628883 2378 dbSNP
rs1364938926 2387 dbSNP
rs1299408318 2392 dbSNP
rs1409862779 2399 dbSNP
rs116633720 2400 dbSNP
rs916595469 2412 dbSNP
rs949394368 2413 dbSNP
rs559206670 2421 dbSNP
rs1412284577 2427 dbSNP
rs1428290782 2427 dbSNP
rs1016082268 2428 dbSNP
rs1379732197 2428 dbSNP
rs1432794339 2429 dbSNP
rs547345967 2430 dbSNP
rs1220024193 2434 dbSNP
rs1472920074 2446 dbSNP
rs1251002451 2455 dbSNP
rs1029885259 2456 dbSNP
rs1256348726 2459 dbSNP
rs1484150587 2459 dbSNP
rs902419913 2463 dbSNP
rs75330772 2467 dbSNP
rs986113177 2467 dbSNP
rs376601790 2468 dbSNP
rs1288347955 2470 dbSNP
rs1408509148 2474 dbSNP
rs759575880 2476 dbSNP
rs1303810266 2478 dbSNP
rs1310175053 2479 dbSNP
rs1209188046 2482 dbSNP
rs200999461 2487 dbSNP
rs936151744 2493 dbSNP
rs769894836 2495 dbSNP
rs949712126 2501 dbSNP
rs1179973934 2505 dbSNP
rs1006608027 2506 dbSNP
rs1256724911 2511 dbSNP
rs905781069 2511 dbSNP
rs1482122084 2518 dbSNP
rs74345535 2521 dbSNP
rs543088241 2527 dbSNP
rs1049444515 2532 dbSNP
rs887647386 2535 dbSNP
rs1005104645 2538 dbSNP
rs532637168 2551 dbSNP
rs1015699811 2554 dbSNP
rs900860050 2556 dbSNP
rs1381018049 2560 dbSNP
rs1391211754 2564 dbSNP
rs1432163371 2566 dbSNP
rs1306787231 2573 dbSNP
rs897219657 2575 dbSNP
rs1353955308 2580 dbSNP
rs1157076374 2583 dbSNP
rs998151293 2586 dbSNP
rs1437316865 2602 dbSNP
rs371836708 2604 dbSNP
rs761258446 2604 dbSNP
rs1365725045 2607 dbSNP
rs1233890921 2608 dbSNP
rs954036466 2610 dbSNP
rs556536049 2612 dbSNP
rs1464176621 2613 dbSNP
rs150670810 2614 dbSNP
rs764348162 2616 dbSNP
rs1211112869 2620 dbSNP
rs545450681 2622 dbSNP
rs951005795 2623 dbSNP
rs751988178 2625 dbSNP
rs1016462259 2626 dbSNP
rs1273830840 2627 dbSNP
rs1357793174 2632 dbSNP
rs989355678 2633 dbSNP
rs75991843 2636 dbSNP
rs1388658757 2637 dbSNP
rs949744068 2640 dbSNP
rs1223160087 2646 dbSNP
rs981184242 2648 dbSNP
rs1487936858 2649 dbSNP
rs1292911883 2654 dbSNP
rs536005044 2655 dbSNP
rs1249025018 2659 dbSNP
rs990924210 2663 dbSNP
rs1391882046 2673 dbSNP
rs572983564 2675 dbSNP
rs936990877 2676 dbSNP
rs139851422 2678 dbSNP
rs971168962 2679 dbSNP
rs1200531972 2683 dbSNP
rs1048996151 2693 dbSNP
rs1451741020 2695 dbSNP
rs982142288 2697 dbSNP
rs1266018055 2699 dbSNP
rs569308123 2703 dbSNP
rs561874272 2706 dbSNP
rs374588927 2713 dbSNP
rs1406506472 2715 dbSNP
rs1341883524 2720 dbSNP
rs1036572824 2724 dbSNP
rs897250598 2728 dbSNP
rs1053603515 2729 dbSNP
rs1166959001 2730 dbSNP
rs1300710691 2732 dbSNP
rs1348274511 2735 dbSNP
rs550205676 2740 dbSNP
rs549717328 2741 dbSNP
rs998257801 2752 dbSNP
rs1428933531 2756 dbSNP
rs1394059214 2757 dbSNP
rs1029687041 2767 dbSNP
rs915105980 2768 dbSNP
rs1478138433 2769 dbSNP
rs878967196 2773 dbSNP
rs1376666907 2779 dbSNP
rs889805410 2785 dbSNP
rs1473254393 2786 dbSNP
rs942519979 2786 dbSNP
rs1254665319 2789 dbSNP
rs1206495515 2790 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uccucuUCCGUGGUACCCUAAAu 5'
                | ||| ||||||:||| 
Target 5' --atctATGCAGCATGGGGTTTt 3'
 		1 - 21
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KICH -0.603 0.01 -0.364 0.09 15 Click to see details
CHOL -0.999 0.01 -1.000 0.5 3 Click to see details
KIRC 0.306 0.06 0.296 0.07 27 Click to see details
BRCA 0.224 0.07 0.191 0.1 46 Click to see details
PRAD 0.471 0.12 0.524 0.09 8 Click to see details
HNSC 0.238 0.19 0.497 0.03 16 Click to see details
UCEC 0.325 0.2 0.133 0.37 9 Click to see details
PAAD -0.722 0.24 -1.000 0.5 3 Click to see details
KIRP -0.143 0.29 -0.150 0.28 17 Click to see details
LUSC -0.081 0.36 -0.078 0.36 23 Click to see details
LIHC 0.063 0.4 -0.009 0.48 20 Click to see details
BLCA 0.082 0.41 0.118 0.36 11 Click to see details
STAD 0.059 0.41 -0.049 0.42 18 Click to see details
THCA 0.026 0.43 -0.018 0.45 48 Click to see details
LUAD 0.016 0.48 -0.017 0.48 9 Click to see details
LUAD 0.016 0.48 -0.017 0.48 9 Click to see details
LUAD 0.016 0.48 -0.017 0.48 9 Click to see details
LUAD 0.016 0.48 -0.017 0.48 9 Click to see details
LUAD 0.016 0.48 -0.017 0.48 9 Click to see details
LUAD 0.016 0.48 -0.017 0.48 9 Click to see details
107 hsa-miR-605-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT001230 SEC24D SEC24 homolog D, COPII coat complex component 3 1
MIRT016155 TP53 tumor protein p53 2 1
MIRT016156 TCEAL1 transcription elongation factor A like 1 1 1
MIRT016157 MDM2 MDM2 proto-oncogene 2 1
MIRT040476 YBX1 Y-box binding protein 1 1 1
MIRT040477 TMEM64 transmembrane protein 64 1 1
MIRT040478 KDM5C lysine demethylase 5C 1 1
MIRT040479 TRAF4 TNF receptor associated factor 4 1 1
MIRT040480 DRG1 developmentally regulated GTP binding protein 1 1 1
MIRT040481 BCL9 B-cell CLL/lymphoma 9 1 1
MIRT055125 SCD stearoyl-CoA desaturase 2 2
MIRT057521 CEP55 centrosomal protein 55 2 2
MIRT081129 LDLR low density lipoprotein receptor 2 6
MIRT096817 ZSWIM6 zinc finger SWIM-type containing 6 2 4
MIRT100961 CENPQ centromere protein Q 2 4
MIRT263338 ANAPC16 anaphase promoting complex subunit 16 2 2
MIRT274710 CPSF6 cleavage and polyadenylation specific factor 6 2 2
MIRT311193 ANKRD33B ankyrin repeat domain 33B 2 2
MIRT360127 DEK DEK proto-oncogene 2 2
MIRT438269 PSMD10 proteasome 26S subunit, non-ATPase 10 2 1
MIRT442464 SLC25A13 solute carrier family 25 member 13 2 2
MIRT446110 TSC22D2 TSC22 domain family member 2 2 2
MIRT463119 ZNF507 zinc finger protein 507 2 2
MIRT470566 POU2F1 POU class 2 homeobox 1 2 2
MIRT475059 IVNS1ABP influenza virus NS1A binding protein 2 6
MIRT482538 ACTB actin beta 2 4
MIRT494136 DCAF7 DDB1 and CUL4 associated factor 7 2 6
MIRT495209 EDN3 endothelin 3 2 2
MIRT495235 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT496762 MANBAL mannosidase beta like 2 2
MIRT498885 ZNF12 zinc finger protein 12 2 10
MIRT499280 NBPF11 NBPF member 11 2 2
MIRT507063 H3F3B H3 histone family member 3B 2 2
MIRT508352 HES7 hes family bHLH transcription factor 7 2 8
MIRT510740 SMC1A structural maintenance of chromosomes 1A 2 6
MIRT519872 ZFP62 ZFP62 zinc finger protein 2 4
MIRT521272 RTN4 reticulon 4 2 4
MIRT522324 NFIB nuclear factor I B 2 6
MIRT525011 ACTN4 actinin alpha 4 2 6
MIRT526608 AASDH aminoadipate-semialdehyde dehydrogenase 2 4
MIRT529043 ARL9 ADP ribosylation factor like GTPase 9 2 2
MIRT529545 ZNF678 zinc finger protein 678 2 2
MIRT532500 HOXA13 homeobox A13 2 2
MIRT532599 SIX4 SIX homeobox 4 2 2
MIRT534044 STK4 serine/threonine kinase 4 2 2
MIRT534087 SPPL3 signal peptide peptidase like 3 2 2
MIRT534249 SLC16A1 solute carrier family 16 member 1 2 2
MIRT534286 SLC12A7 solute carrier family 12 member 7 2 2
MIRT534555 RUNX1 runt related transcription factor 1 2 2
MIRT536765 HOXB2 homeobox B2 2 2
MIRT537227 GAN gigaxonin 2 2
MIRT551105 TTC8 tetratricopeptide repeat domain 8 2 2
MIRT552247 DUSP3 dual specificity phosphatase 3 2 2
MIRT554361 SFXN5 sideroflexin 5 2 2
MIRT557402 H3F3C H3 histone family member 3C 2 2
MIRT559116 C16orf52 chromosome 16 open reading frame 52 2 2
MIRT560494 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT562296 GLO1 glyoxalase I 2 2
MIRT562597 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT563857 ALYREF Aly/REF export factor 2 4
MIRT565665 SIX1 SIX homeobox 1 2 2
MIRT568253 BTF3L4 basic transcription factor 3 like 4 2 2
MIRT609593 GPM6B glycoprotein M6B 2 2
MIRT611552 GGT6 gamma-glutamyltransferase 6 2 2
MIRT613451 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT615516 PRRC2A proline rich coiled-coil 2A 2 2
MIRT617766 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT619134 MCOLN3 mucolipin 3 2 2
MIRT621365 CAP2 cyclase associated actin cytoskeleton regulatory protein 2 2 2
MIRT625804 MDC1 mediator of DNA damage checkpoint 1 2 2
MIRT626954 PRDM2 PR/SET domain 2 2 2
MIRT627716 RCAN1 regulator of calcineurin 1 2 2
MIRT628069 KCNJ13 potassium voltage-gated channel subfamily J member 13 2 2
MIRT630451 GTPBP8 GTP binding protein 8 (putative) 2 2
MIRT635533 ELMOD2 ELMO domain containing 2 2 2
MIRT636206 SULF2 sulfatase 2 2 2
MIRT638763 EPHA4 EPH receptor A4 2 2
MIRT640324 STAT1 signal transducer and activator of transcription 1 2 2
MIRT644548 SPOP speckle type BTB/POZ protein 2 2
MIRT645114 TMX2 thioredoxin related transmembrane protein 2 2 2
MIRT647778 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT650112 ZCCHC9 zinc finger CCHC-type containing 9 2 2
MIRT650136 ABCB7 ATP binding cassette subfamily B member 7 2 2
MIRT650310 SLC35E2 solute carrier family 35 member E2 2 2
MIRT650930 ST6GALNAC1 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2 2
MIRT651018 ZNF740 zinc finger protein 740 2 2
MIRT653541 SLC38A9 solute carrier family 38 member 9 2 2
MIRT655752 NR2C2 nuclear receptor subfamily 2 group C member 2 2 2
MIRT656908 KIAA1958 KIAA1958 2 2
MIRT657854 GJD3 gap junction protein delta 3 2 2
MIRT658215 FBXO21 F-box protein 21 2 2
MIRT659884 CAPN7 calpain 7 2 2
MIRT659922 CACNA1E calcium voltage-gated channel subunit alpha1 E 2 2
MIRT660055 C12orf5 TP53 induced glycolysis regulatory phosphatase 1 1
MIRT664616 LIMD1 LIM domains containing 1 2 2
MIRT665392 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT667887 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT669018 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT688419 DUSP2 dual specificity phosphatase 2 2 2
MIRT691888 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT709530 GEN1 GEN1, Holliday junction 5' flap endonuclease 2 2
MIRT711013 ABCD2 ATP binding cassette subfamily D member 2 2 2
MIRT714731 CENPH centromere protein H 2 2
MIRT719897 PTGIS prostaglandin I2 synthase 2 2
MIRT725028 CX3CL1 C-X3-C motif chemokine ligand 1 2 2
MIRT734348 P2RY12 purinergic receptor P2Y12 3 0
MIRT736719 TNFAIP3 TNF alpha induced protein 3 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-605 Anthranilamide-pyrazolo[1,5-a]pyrimidine NULL NULL Quantitative real-time PCR neuroblastoma cells 23992861 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-605 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-605 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-605-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-605-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-605-5p Navitoclax 24978538 NSC759659 sensitive High Colorectal Cancer cell line (HCT-116, CHL1)
hsa-miR-605-5p Gemcitabine 60750 NSC613327 approved sensitive Low Pancreatic Cancer cell line (BxPC‐3, PANC‐1)
hsa-miR-605-5p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (H358, H1155)
hsa-miR-605-5p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer tissue
hsa-miR-605-5p Fluorouracil 3385 NSC19893 approved sensitive High Gastric Cancer tissue
hsa-miR-605-5p Fluorouracil 3385 NSC19893 approved resistant Low Colon Cancer cell line (HT-29, LoVo)
hsa-miR-605-5p Everolimus + Panobinostat sensitive Low Clear Cell Renal Cell Carcinoma tissue
hsa-miR-605-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-605-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-605-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-605-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-605-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-605-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-605-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-605-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-605-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-605-5p Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-605-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-605-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-605-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-605-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-605-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (OVCAR3)
hsa-miR-605-5p Cisplatin 5460033 NSC119875 approved resistant cell line (H460)
hsa-miR-605-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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