miRTarBase - #MIRT041072


—
pre-miRNA Information
pre-miRNA hsa-mir-504   
Genomic Coordinates chrX: 138667711 - 138667793
Synonyms MIRN504, hsa-mir-504, MIR504
Description Homo sapiens miR-504 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-504-5p
Sequence 13| AGACCCUGGUCUGCACUCUAUC |34
Evidence Experimental
Experiments Array-cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1297440872 6 dbSNP
rs1429220261 12 dbSNP
rs745623382 14 dbSNP
rs770027520 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol P2RY13   
Synonyms FKSG77, GPCR1, GPR86, GPR94, P2Y13, SP174
Description purinergic receptor P2Y13
Transcript NM_176894   
Expression
Putative miRNA Targets on P2RY13
3'UTR of P2RY13
(miRNA target sites are highlighted)		 
>P2RY13|NM_176894|3'UTR
   1 CAACTGTACATAGGGTTAACTTCTATTTATTGATGAGACTTCCGTAGATAATGTGGAAATCAAATTTAACCAAGAAAAAA
  81 AGATTGGAACAAATGCTCTCTTACATTTTATTATCCTCGTGTACAGAAAAGATTATATAAAATTTAAATCCACATAGATC
 161 TATTCATAAGCTGAATGAACCATTACTAAGAGAATGCAACAGGATACAAATGGCCACTAGAGGTCATTATTTCTTTCTTT
 241 CTTTTTTTTTTTTTTTAATTTCAAGAGCATTTCACTTTAACATTTTGGAAAAGACTAAGGAGAAACGTATATCCCTACAA
 321 ACCTCCCCTCCAAACACCTTCTCACATTCTTTTCCACAATTCACATAACACTACTGCTTTTGTGCCCCTTAAATGTAGAT
 401 ATGTGCTGAAAGAAAAAAAAAACGCCCAACTCTTGAAGTCCATTGCTGAAAACTGCAGCCAGGGGTTGAAAGGGATGCAG
 481 ACTTGAAGAGTCTGAGGAACTGAAGTGGGTCAGCAAGACCTCTGAAATCCTGGGTAAAGGATTTTCTCCTTACAATTACA
 561 AACAGCCTCTTTCACATTACAATAATATACCATAGGAGGCACAAGCACCATTATTAAGCCACTTTGCTTACACCTTAAGT
 641 GTGTACAATTCAAGTGTGAGAATGCTGTGTTAACTATTCTTTGGAATTCTCCTTCTGTCCAGCAAATACTCTAATGATGG
 721 TTAAACATGGCACCTACTCAGCAATGCCTTCCTGGACCACAACCCCTATCCCCCTGCCCCACCCTCCTCATTAAAAACAA
 801 ATACTTCTACTGTTTGGGTGTGTGATAGGGTTCTCAATGCAGATCTCCCTTTTCTAGTTAGCTATATTCTTGACTGCATC
 881 CGCTAAAAATGTTAAAGCTTCTTGAGAGACAGACATGCCAGATTTTCTTGGTATCTCCCATAATACGACCTACAGTCCAT
 961 GGTCTACAGATGTTTTAAATAGAATTGCTATTCTCGATACATACAAAGACGTAATTGCTGACCCACAATCAGTAACATCC
1041 ATATTGAGAGATTTTTCAAAGGATGGTGACCCTGCTTGTATTTATTTACCTTGGTATTTTTTCTTGCATCCTTCTGTGAT
1121 TCAAAAAAGTAAAATGTGGCTTTCTGAAATGATGGATAAGAGTCTACATCTTCTAGAAAAAATACATAAAGGAGTAGTTA
1201 AGCTCTGTAAATGTGCCACGAGCTCCAACACGACCATCGTAGGGTGAAGCCCACGTTTTCTTCCATGGCCTCAAAGGCCC
1281 TAGAACTTGCCTACCTTTCTGGCCTTACCTCCTAGCTACTTATCCATCTCTTGAACTTTATACTCTTGTATAAATTTCTA
1361 ACTTTCAGAAAATGCCATACTCTGTTTTGGCACCACACATGTATATTTCCCCCTGGTACACTTGGAAGACTCTTATCCAT
1441 CTGTGAAACCCTATGTTGTCATCACTTGGTCCATGAAATATTACCTGGCCAATATCCCACCATCACCTCAAACCCAATCA
1521 CCCCCTCCTCTGTATGCTGTCACACCTATATTATTAAACTTATCACATTGCATTGTAATTACTTCCTGACCTTTGTATCT
1601 ACTCTTTTAGTAACTGATGTATATATCTGAAAGGAGAGATTGTTTCATTGTGCAATCAATAAATGTTTGATAAAATAAAG
1681 CCC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuAUCUCACGUCUGGUCCCAGa 5'
            | |:|||:: : :|||||: 
Target 5' gtTTGGGTGTGTGATAGGGTTc 3'
 812 - 833 128.00 -14.70
2 
miRNA  3' cuAU-CU-CACGUCUGGUCCCAGa 5'
            || ||  | ||| ||| |||| 
Target 5' aaTACGACCTACAGTCCATGGTCt 3'
 942 - 965 128.00 -14.80
3 
miRNA  3' cuaUCUCACGUCUGGUCCCaga 5'
             | | ||||| ||||||   
Target 5' tgaAAACTGCAG-CCAGGGgtt 3'
 447 - 467 126.00 -16.82
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31497275 13 COSMIC
COSN30133626 18 COSMIC
COSN31525173 27 COSMIC
COSN30155878 42 COSMIC
COSN30145365 47 COSMIC
COSN31608870 91 COSMIC
COSN31599756 98 COSMIC
COSN31601660 100 COSMIC
COSN30493376 103 COSMIC
COSN30113649 108 COSMIC
COSN28692496 118 COSMIC
COSN31574804 131 COSMIC
COSN30521421 134 COSMIC
COSN30115373 141 COSMIC
COSN30167129 158 COSMIC
COSN17543621 227 COSMIC
COSN20099239 241 COSMIC
COSN20099241 242 COSMIC
COSN20099243 242 COSMIC
COSN9136220 409 COSMIC
COSN28491068 412 COSMIC
COSN28233806 658 COSMIC
COSN28236244 659 COSMIC
COSN18945129 903 COSMIC
COSN9759893 995 COSMIC
COSN26107549 1010 COSMIC
COSN21451763 1161 COSMIC
COSN7825973 1265 COSMIC
COSN16685496 1651 COSMIC
COSN31610008 1669 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1354757464 11 dbSNP
rs1339707516 15 dbSNP
rs757522402 19 dbSNP
rs1238106374 21 dbSNP
rs200506425 23 dbSNP
rs777682182 24 dbSNP
rs924974733 34 dbSNP
rs575842008 35 dbSNP
rs375255769 43 dbSNP
rs754383321 44 dbSNP
rs751098191 46 dbSNP
rs545657330 50 dbSNP
rs745666599 51 dbSNP
rs573827831 52 dbSNP
rs1390963639 53 dbSNP
rs184696884 54 dbSNP
rs1039064223 61 dbSNP
rs553748721 70 dbSNP
rs1437790765 71 dbSNP
rs909238531 81 dbSNP
rs983401630 84 dbSNP
rs926791372 85 dbSNP
rs1307008728 98 dbSNP
rs372435927 103 dbSNP
rs963085531 104 dbSNP
rs747162326 106 dbSNP
rs929594416 108 dbSNP
rs1207997684 116 dbSNP
rs1491980 118 dbSNP
rs992738311 119 dbSNP
rs959533548 120 dbSNP
rs1248888658 123 dbSNP
rs1033860803 125 dbSNP
rs1161595536 126 dbSNP
rs979152971 133 dbSNP
rs777623166 148 dbSNP
rs967772845 149 dbSNP
rs1406505126 154 dbSNP
rs111263026 155 dbSNP
rs192372273 157 dbSNP
rs1437770144 161 dbSNP
rs1321567171 164 dbSNP
rs757920030 173 dbSNP
rs1009231346 175 dbSNP
rs1285484896 176 dbSNP
rs891078401 180 dbSNP
rs1227192441 189 dbSNP
rs1266195029 202 dbSNP
rs903571407 205 dbSNP
rs1209138378 207 dbSNP
rs1255204365 209 dbSNP
rs146935654 211 dbSNP
rs1185653522 217 dbSNP
rs945065046 219 dbSNP
rs1475592023 223 dbSNP
rs1181502664 226 dbSNP
rs1259776244 227 dbSNP
rs1410411546 229 dbSNP
rs1188880124 233 dbSNP
rs1459270402 235 dbSNP
rs1488112929 237 dbSNP
rs896145812 237 dbSNP
rs201793458 241 dbSNP
rs1203170207 242 dbSNP
rs398052362 242 dbSNP
rs1261231565 244 dbSNP
rs11712291 245 dbSNP
rs1352323371 245 dbSNP
rs1408692730 245 dbSNP
rs1228926444 246 dbSNP
rs1244065126 246 dbSNP
rs938227268 247 dbSNP
rs1038147535 249 dbSNP
rs1201919581 249 dbSNP
rs1294649332 256 dbSNP
rs1204593663 257 dbSNP
rs1249704420 257 dbSNP
rs1439164563 257 dbSNP
rs1456296170 257 dbSNP
rs1486084887 257 dbSNP
rs63497161 257 dbSNP
rs1414967273 258 dbSNP
rs1339480449 262 dbSNP
rs1316594387 265 dbSNP
rs1384287700 268 dbSNP
rs1371835861 270 dbSNP
rs1410409119 277 dbSNP
rs867257823 281 dbSNP
rs1300539297 289 dbSNP
rs532583215 299 dbSNP
rs1329240244 301 dbSNP
rs1235152308 306 dbSNP
rs746043341 307 dbSNP
rs974185271 312 dbSNP
rs141189011 317 dbSNP
rs1006287847 318 dbSNP
rs1386204313 323 dbSNP
rs941475108 326 dbSNP
rs1460371353 329 dbSNP
rs1420081052 335 dbSNP
rs1196413188 336 dbSNP
rs1165774895 340 dbSNP
rs1477593989 351 dbSNP
rs1240595818 355 dbSNP
rs1396064733 356 dbSNP
rs1448544855 361 dbSNP
rs1166309434 365 dbSNP
rs1391583353 377 dbSNP
rs908646047 382 dbSNP
rs371595361 383 dbSNP
rs955590237 387 dbSNP
rs138729155 388 dbSNP
rs1262218722 395 dbSNP
rs975998751 400 dbSNP
rs1295715619 402 dbSNP
rs964588222 407 dbSNP
rs1209143584 408 dbSNP
rs1467102267 409 dbSNP
rs1274465837 411 dbSNP
rs1233367467 412 dbSNP
rs1254074978 423 dbSNP
rs1257148986 423 dbSNP
rs1464747728 423 dbSNP
rs147472981 423 dbSNP
rs368884582 423 dbSNP
rs188038540 424 dbSNP
rs1268031302 430 dbSNP
rs1229239700 438 dbSNP
rs887854100 442 dbSNP
rs1163534430 443 dbSNP
rs1323366020 446 dbSNP
rs1439278551 447 dbSNP
rs779364031 452 dbSNP
rs1021157662 455 dbSNP
rs1009317109 457 dbSNP
rs1432638130 458 dbSNP
rs1364421311 459 dbSNP
rs896144428 473 dbSNP
rs1388627 484 dbSNP
rs918171330 485 dbSNP
rs905431876 488 dbSNP
rs530959531 493 dbSNP
rs1247022911 498 dbSNP
rs1274388674 499 dbSNP
rs1329005589 502 dbSNP
rs1056691123 505 dbSNP
rs1270404364 508 dbSNP
rs1486011646 510 dbSNP
rs1475892826 512 dbSNP
rs1373384996 518 dbSNP
rs1192808832 520 dbSNP
rs1253581231 524 dbSNP
rs1388628 533 dbSNP
rs1254825449 534 dbSNP
rs1411163093 535 dbSNP
rs1455565348 542 dbSNP
rs1161186807 545 dbSNP
rs1214308064 548 dbSNP
rs1436718218 551 dbSNP
rs1345535471 553 dbSNP
rs941552253 554 dbSNP
rs201782117 559 dbSNP
rs908700334 561 dbSNP
rs926801583 575 dbSNP
rs1416708375 578 dbSNP
rs545993682 589 dbSNP
rs1274585598 593 dbSNP
rs1350481571 595 dbSNP
rs1227091919 596 dbSNP
rs934050515 598 dbSNP
rs1317917642 599 dbSNP
rs538731422 602 dbSNP
rs1253886764 605 dbSNP
rs1483995074 626 dbSNP
rs1373724995 631 dbSNP
rs576934255 633 dbSNP
rs913654059 634 dbSNP
rs1184230143 643 dbSNP
rs1304806872 655 dbSNP
rs554037398 661 dbSNP
rs1352820266 671 dbSNP
rs987810229 677 dbSNP
rs955035253 680 dbSNP
rs1017556745 682 dbSNP
rs756685530 682 dbSNP
rs1408018640 687 dbSNP
rs571422782 701 dbSNP
rs968326018 703 dbSNP
rs544012235 709 dbSNP
rs996797948 719 dbSNP
rs1020747593 721 dbSNP
rs1009739763 726 dbSNP
rs896213379 727 dbSNP
rs1234529726 731 dbSNP
rs184346302 733 dbSNP
rs1481799874 734 dbSNP
rs1001850633 747 dbSNP
rs1452325297 754 dbSNP
rs1396728867 756 dbSNP
rs1189314661 763 dbSNP
rs1016756053 764 dbSNP
rs192611131 766 dbSNP
rs1469605200 773 dbSNP
rs1174517537 777 dbSNP
rs1005338738 779 dbSNP
rs1038621349 783 dbSNP
rs1183392654 784 dbSNP
rs766913431 789 dbSNP
rs878992932 793 dbSNP
rs1437979945 794 dbSNP
rs887865383 804 dbSNP
rs187745054 808 dbSNP
rs1350468376 810 dbSNP
rs887274904 817 dbSNP
rs1373619979 823 dbSNP
rs1047191942 826 dbSNP
rs537821753 837 dbSNP
rs1296459434 838 dbSNP
rs1339553995 840 dbSNP
rs1047768947 842 dbSNP
rs934081876 849 dbSNP
rs575333352 851 dbSNP
rs79276520 858 dbSNP
rs1371850904 860 dbSNP
rs183103502 868 dbSNP
rs12497019 876 dbSNP
rs1340005031 878 dbSNP
rs1169793468 879 dbSNP
rs766160899 881 dbSNP
rs145905270 885 dbSNP
rs536589476 886 dbSNP
rs116539054 891 dbSNP
rs377314521 898 dbSNP
rs1405706967 902 dbSNP
rs987969952 904 dbSNP
rs1178370522 909 dbSNP
rs1362660762 912 dbSNP
rs1432458836 916 dbSNP
rs1270312602 918 dbSNP
rs1377786015 925 dbSNP
rs987883094 931 dbSNP
rs1274977487 932 dbSNP
rs1335327575 937 dbSNP
rs550594000 938 dbSNP
rs960512668 939 dbSNP
rs1266000475 940 dbSNP
rs1034763808 941 dbSNP
rs1242868081 947 dbSNP
rs955278951 951 dbSNP
rs1472527866 953 dbSNP
rs1185321742 960 dbSNP
rs1180123017 973 dbSNP
rs922320047 976 dbSNP
rs1420672337 979 dbSNP
rs6775648 983 dbSNP
rs1158983823 985 dbSNP
rs565400766 986 dbSNP
rs1386876241 987 dbSNP
rs551537497 992 dbSNP
rs1318596711 995 dbSNP
rs964033067 996 dbSNP
rs1215527662 1002 dbSNP
rs1445189078 1004 dbSNP
rs532342069 1010 dbSNP
rs1356083817 1011 dbSNP
rs1005348804 1015 dbSNP
rs1227675667 1017 dbSNP
rs1286936903 1018 dbSNP
rs1286280561 1021 dbSNP
rs1352601418 1022 dbSNP
rs1016558619 1027 dbSNP
rs1224889942 1034 dbSNP
rs1006223421 1036 dbSNP
rs1208897147 1037 dbSNP
rs112519080 1041 dbSNP
rs1291563086 1044 dbSNP
rs6440735 1047 dbSNP
rs1356372327 1052 dbSNP
rs1182065225 1054 dbSNP
rs1313193305 1062 dbSNP
rs1471361926 1064 dbSNP
rs993620282 1067 dbSNP
rs151308567 1069 dbSNP
rs896551593 1072 dbSNP
rs1159446366 1075 dbSNP
rs1244009347 1078 dbSNP
rs1429785003 1079 dbSNP
rs1412394063 1103 dbSNP
rs1343286221 1105 dbSNP
rs1161164699 1108 dbSNP
rs531279204 1110 dbSNP
rs1408635209 1112 dbSNP
rs1002614891 1115 dbSNP
rs1306140994 1127 dbSNP
rs901328601 1129 dbSNP
rs1239521589 1136 dbSNP
rs905447703 1137 dbSNP
rs1274016825 1138 dbSNP
rs561152749 1139 dbSNP
rs1039850551 1141 dbSNP
rs1282628849 1144 dbSNP
rs1486055251 1148 dbSNP
rs942721505 1153 dbSNP
rs925950702 1156 dbSNP
rs1043032576 1162 dbSNP
rs946643035 1169 dbSNP
rs1162213986 1183 dbSNP
rs1452237812 1183 dbSNP
rs1175149894 1188 dbSNP
rs1395268285 1191 dbSNP
rs1475947986 1195 dbSNP
rs1165595466 1206 dbSNP
rs1398622435 1211 dbSNP
rs1418143956 1215 dbSNP
rs1185633329 1216 dbSNP
rs1391894708 1219 dbSNP
rs1322700782 1220 dbSNP
rs1043969745 1226 dbSNP
rs764306723 1231 dbSNP
rs772003307 1232 dbSNP
rs79904629 1234 dbSNP
rs1348815102 1237 dbSNP
rs1053017235 1238 dbSNP
rs933788425 1239 dbSNP
rs1342167854 1241 dbSNP
rs113237092 1242 dbSNP
rs1267206538 1243 dbSNP
rs975108050 1249 dbSNP
rs942335253 1254 dbSNP
rs1195847390 1255 dbSNP
rs558625192 1255 dbSNP
rs909815712 1259 dbSNP
rs1190446028 1261 dbSNP
rs1295107867 1263 dbSNP
rs983979140 1265 dbSNP
rs1462481618 1270 dbSNP
rs1213073564 1278 dbSNP
rs183428748 1290 dbSNP
rs1462842903 1292 dbSNP
rs16863317 1320 dbSNP
rs993063527 1321 dbSNP
rs1372057663 1327 dbSNP
rs1435675011 1333 dbSNP
rs771425985 1335 dbSNP
rs951101646 1336 dbSNP
rs1323243702 1346 dbSNP
rs1025924929 1348 dbSNP
rs960863665 1349 dbSNP
rs1333266718 1366 dbSNP
rs1035477523 1380 dbSNP
rs998435392 1386 dbSNP
rs1464210572 1388 dbSNP
rs1002219977 1393 dbSNP
rs1263326018 1396 dbSNP
rs191166506 1403 dbSNP
rs1169269871 1407 dbSNP
rs1415652701 1408 dbSNP
rs536427781 1410 dbSNP
rs1006991854 1411 dbSNP
rs1422030128 1412 dbSNP
rs904581296 1415 dbSNP
rs1043515254 1422 dbSNP
rs1463988013 1449 dbSNP
rs1287340502 1450 dbSNP
rs1011189214 1451 dbSNP
rs946096201 1454 dbSNP
rs1292725005 1455 dbSNP
rs567633607 1456 dbSNP
rs1052404656 1460 dbSNP
rs1251695785 1470 dbSNP
rs1214005800 1473 dbSNP
rs1262151050 1481 dbSNP
rs892713052 1486 dbSNP
rs1199431890 1487 dbSNP
rs749737084 1489 dbSNP
rs1254774262 1497 dbSNP
rs939235216 1502 dbSNP
rs577780067 1510 dbSNP
rs934113111 1522 dbSNP
rs758121452 1523 dbSNP
rs1417114839 1529 dbSNP
rs1250879876 1535 dbSNP
rs1202636487 1537 dbSNP
rs900926960 1541 dbSNP
rs1309517390 1546 dbSNP
rs1297374904 1550 dbSNP
rs113844070 1551 dbSNP
rs1373694115 1556 dbSNP
rs1416632758 1559 dbSNP
rs1228889799 1563 dbSNP
rs1039831986 1567 dbSNP
rs550833033 1568 dbSNP
rs1370056281 1570 dbSNP
rs756732755 1571 dbSNP
rs753106587 1572 dbSNP
rs1317215892 1575 dbSNP
rs1232064766 1591 dbSNP
rs1301156637 1595 dbSNP
rs1277681233 1599 dbSNP
rs947826478 1608 dbSNP
rs1210931524 1618 dbSNP
rs186193837 1620 dbSNP
rs1251021267 1623 dbSNP
rs1479605362 1624 dbSNP
rs1443063621 1626 dbSNP
rs1250964406 1627 dbSNP
rs1419956413 1635 dbSNP
rs1173260329 1636 dbSNP
rs1393425320 1638 dbSNP
rs180809596 1639 dbSNP
rs983738747 1640 dbSNP
rs1354514351 1650 dbSNP
rs984265728 1652 dbSNP
rs1300331926 1655 dbSNP
rs929929960 1664 dbSNP
rs1440544058 1667 dbSNP
rs1355923938 1669 dbSNP
rs1349540466 1671 dbSNP
rs1025692948 1676 dbSNP
rs1305762665 1680 dbSNP
rs977009148 1680 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
COAD 0.984 0 0.900 0.02 5 Click to see details
THCA -0.41 0 -0.375 0 49 Click to see details
CHOL -0.868 0.01 -0.786 0.02 7 Click to see details
LIHC 0.381 0.01 0.329 0.02 43 Click to see details
KICH 0.403 0.02 0.228 0.14 25 Click to see details
KIRC 0.266 0.03 0.317 0.01 51 Click to see details
HNSC -0.335 0.04 -0.294 0.06 28 Click to see details
KIRP 0.29 0.07 0.313 0.05 28 Click to see details
ESCA 0.345 0.28 0.200 0.37 5 Click to see details
UCEC -0.141 0.31 -0.118 0.34 15 Click to see details
LUSC -0.095 0.31 -0.003 0.49 29 Click to see details
PRAD -0.069 0.32 -0.018 0.45 50 Click to see details
BRCA -0.043 0.37 -0.012 0.46 65 Click to see details
BLCA -0.098 0.37 -0.002 0.5 14 Click to see details
LUAD 0.09 0.4 0.064 0.43 11 Click to see details
PAAD 0.203 0.4 -0.400 0.3 4 Click to see details
STAD 0.002 0.5 -0.050 0.41 24 Click to see details
STAD 0.002 0.5 -0.050 0.41 24 Click to see details
STAD 0.002 0.5 -0.050 0.41 24 Click to see details
STAD 0.002 0.5 -0.050 0.41 24 Click to see details
STAD 0.002 0.5 -0.050 0.41 24 Click to see details
101 hsa-miR-504-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000044 DRD1 dopamine receptor D1 2 1
MIRT004457 VEGFA vascular endothelial growth factor A 2 1
MIRT016249 BAX BCL2 associated X, apoptosis regulator 1 1
MIRT016251 GADD45A growth arrest and DNA damage inducible alpha 1 1
MIRT016252 FAS Fas cell surface death receptor 1 1
MIRT016253 BBC3 BCL2 binding component 3 1 1
MIRT016254 TP53I3 tumor protein p53 inducible protein 3 1 1
MIRT016255 TCEAL1 transcription elongation factor A like 1 2 1
MIRT016256 MDM2 MDM2 proto-oncogene 2 1
MIRT016257 TP53 tumor protein p53 3 1
MIRT041072 P2RY13 purinergic receptor P2Y13 1 1
MIRT041073 PPIL1 peptidylprolyl isomerase like 1 1 1
MIRT041074 ZNF814 zinc finger protein 814 1 1
MIRT041075 HIST1H2AC histone cluster 1 H2A family member c 1 1
MIRT041076 FEM1A fem-1 homolog A 1 1
MIRT041077 TXNRD1 thioredoxin reductase 1 1 1
MIRT041078 RAI1 retinoic acid induced 1 1 1
MIRT041079 SRRM2 serine/arginine repetitive matrix 2 1 1
MIRT041080 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 1 1
MIRT041081 PDLIM1 PDZ and LIM domain 1 1 1
MIRT041082 FAM208B family with sequence similarity 208 member B 1 1
MIRT041083 PSAT1 phosphoserine aminotransferase 1 1 1
MIRT041084 TMEM8A transmembrane protein 8A 1 1
MIRT041085 RABGAP1 RAB GTPase activating protein 1 1 1
MIRT041086 BRD2 bromodomain containing 2 1 1
MIRT041087 C11orf58 chromosome 11 open reading frame 58 1 1
MIRT041088 CNOT8 CCR4-NOT transcription complex subunit 8 1 1
MIRT041089 RPL10 ribosomal protein L10 1 1
MIRT041090 SMCR7L mitochondrial elongation factor 1 1 1
MIRT041091 CENPBD1 CENPB DNA-binding domain containing 1 1 1
MIRT041092 SF3B1 splicing factor 3b subunit 1 1 1
MIRT041093 MTFP1 mitochondrial fission process 1 1 1
MIRT438313 CDK6 cyclin dependent kinase 6 1 1
MIRT438352 TFF1 trefoil factor 1 3 1
MIRT443009 KBTBD12 kelch repeat and BTB domain containing 12 2 2
MIRT448052 SFRP1 secreted frizzled related protein 1 2 2
MIRT457649 ZNF69 zinc finger protein 69 2 2
MIRT458626 TRIM72 tripartite motif containing 72 2 2
MIRT466176 TMED5 transmembrane p24 trafficking protein 5 2 2
MIRT472583 NACC1 nucleus accumbens associated 1 2 2
MIRT473576 MAT2A methionine adenosyltransferase 2A 2 6
MIRT485155 RASL10B RAS like family 10 member B 2 2
MIRT490063 PRRT2 proline rich transmembrane protein 2 2 2
MIRT493015 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT499425 PLCG2 phospholipase C gamma 2 2 11
MIRT506956 HOXB3 homeobox B3 2 4
MIRT507100 GPCPD1 glycerophosphocholine phosphodiesterase 1 2 2
MIRT508101 ANKRD33B ankyrin repeat domain 33B 2 4
MIRT522215 NR2C2 nuclear receptor subfamily 2 group C member 2 2 6
MIRT530327 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT531042 ZNF502 zinc finger protein 502 2 2
MIRT532580 GSS glutathione synthetase 2 2
MIRT534841 RAB15 RAB15, member RAS oncogene family 2 2
MIRT536820 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT538303 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT546344 TFAP2C transcription factor AP-2 gamma 2 2
MIRT546704 RORA RAR related orphan receptor A 2 4
MIRT549222 BCL2L11 BCL2 like 11 2 4
MIRT549623 TMEM101 transmembrane protein 101 2 2
MIRT549931 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT550163 ZNF223 zinc finger protein 223 2 4
MIRT550555 ARSK arylsulfatase family member K 2 2
MIRT553402 TRIM2 tripartite motif containing 2 2 4
MIRT554084 SNX4 sorting nexin 4 2 4
MIRT556962 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT558525 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT558565 CRLF3 cytokine receptor like factor 3 2 4
MIRT560946 TPM4 tropomyosin 4 2 4
MIRT561628 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT562174 HOXA13 homeobox A13 2 2
MIRT568635 ACVR2A activin A receptor type 2A 2 2
MIRT574908 Plcg2 phospholipase C, gamma 2 2 7
MIRT575177 Atg9a autophagy related 9A 2 2
MIRT611972 PKD1 polycystin 1, transient receptor potential channel interacting 2 2
MIRT613623 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT635830 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 4
MIRT637344 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 4
MIRT643205 JAK3 Janus kinase 3 2 2
MIRT650232 SIGLEC9 sialic acid binding Ig like lectin 9 2 2
MIRT655940 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT662021 ZNF445 zinc finger protein 445 2 2
MIRT662037 FUT2 fucosyltransferase 2 2 2
MIRT666873 POU2F2 POU class 2 homeobox 2 2 2
MIRT684310 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT687333 OSMR oncostatin M receptor 2 2
MIRT689008 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT695137 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695154 PRY PTPN13-like, Y-linked 2 2
MIRT700695 POLR3D RNA polymerase III subunit D 2 2
MIRT703269 GNL3L G protein nucleolar 3 like 2 2
MIRT708941 CRY2 cryptochrome circadian clock 2 2 2
MIRT709200 SAPCD2 suppressor APC domain containing 2 2 2
MIRT709572 PDE4A phosphodiesterase 4A 2 2
MIRT711295 PSME3 proteasome activator subunit 3 2 2
MIRT712425 MACROD2 MACRO domain containing 2 2 2
MIRT713941 PIGR polymeric immunoglobulin receptor 2 2
MIRT714124 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT714630 KIAA1143 KIAA1143 2 2
MIRT724046 SMIM14 small integral membrane protein 14 2 2
MIRT724649 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT725476 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-504 Emodin NULL 3220 Microarray K562 cells 23744534 2013 down-regualted
miR-504 Mistletoe lectin-I NULL NULL Microarray colorectal cancer cells CLY cells 20955366 2011 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-504 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-504 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-504 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-504-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-504-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-504-5p Plx-4720 24180719 NSC757438 sensitive High Thyroid Cancer cell line (8505c, BCPAP)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-504-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7, MCF-7-TT)
hsa-miR-504-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-504-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (A375)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-504-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-504-5p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-504-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-504-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-504-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved resistant cell line (H460)

Error report submission